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LEHHTDAAQDDVVTDDEDRRPIADLPDALDHFDEIRDLLAFRNPASLPVFIGNPADDSAFRTVRRDGIGI VVVTHAEDEKRSTTATFRLDSPGAAATFRHRLAQEADRPTSIDPGWVLTFDGYDPANERFREALCTLGNG YFATRGCAPEAPAGRFHYPGTYVAGIYNRLTDEIAGHRTDNESLVNLPNWLALTFRFDDGPWLDVDDTDL QSYQQTLDLRRGVLTRQFRFCDKAGRVATVTQHRLVAMHLPHLAMLQTMVTAENFSGTVEFRSEIDGAVT NSLVERYRDLSNVHLVGHEKRSLTADSLLLTAHTCQSHIRVAVALRNTVWRGDSPARADYTLVDDRRRAG HVISCYIEAGQPVTLEKAVSVATSRDHATCEAANEATRRLQWVDRYHDVQQAHTTAWGQLWERFDVDIGG RTDELRTVRLHLLHTLQTLSPHVRDLDIGVPARGLTGEAYRGHIFWDELFVAPVVSLRRPALTRALLAYR HRRLPEARRAARDAGFTGAMFPWQSGSNGREESPALHLNPRSGRWNPDPSALAHHVGLAVAYNIWQYYQV TDDLEYLIDYGAETLLEIARFWAGLALFSRERGRYVIPGVIGPDEFHTGYPGRLYDGIDNNAYTNVMAVW VILRALDALDAMPLADRTALLERLGLHGDELDKWEDVSHRMFVPFHNGVISQFEGYESLVELDWDRYRHE YGNIQRLDRILEAENDNVNRYKASKQADVLMLFYLLSADEIRELLARLGYRFTPKQIPETVDYYLSRTSH GSTLSAVVHSWVLARGHREQAMEFFVQALNSDVADIQGGTTAEGIHLAAMAGSVDLLQRCFTGLETRGDR LVLGPCWPEALGVLSFRMYYRGHNLHLRVSGRTASVISAIGSAAPITLECRGRTWQLCAGTTIDVG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_3954 | - | - | 100% (906) | trehalose 6-phosphate phosphorylase |
| M. smegmatis MC2 155 | MSMEG_1608 | - | 1e-54 | 28.70% (763) | glycosyl transferase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2029 | otsB1 | 0.0 | 62.83% (861) | trehalose-6-phosphate phosphatase OtsB1 |
| M. gilvum PYR-GCK | Mflv_4989 | - | 0.0 | 60.86% (861) | HAD family hydrolase |
| M. tuberculosis H37Rv | Rv2006 | otsB1 | 0.0 | 62.95% (861) | trehalose-6-phosphate phosphatase OtsB1 |
| M. leprae Br4923 | MLBr_00392 | - | 1e-50 | 27.14% (781) | putative sugar phosphorylase |
| M. abscessus ATCC 19977 | - | - | - | - | - |
| M. marinum M | MMAR_2257 | otsB1 | 0.0 | 59.98% (867) | trehalose-6-phosphate phosphatase OtsB1 |
| M. avium 104 | MAV_4352 | - | 1e-53 | 27.06% (787) | glycoside hydrolase family protein 65, central catalytic |
| M. thermoresistible (build 8) | TH_1155 | - | 0.0 | 61.74% (860) | trehalose 6-phosphate phosphorylase |
| M. ulcerans Agy99 | MUL_0906 | - | 1e-41 | 27.14% (619) | glycosyl hydrolase |
| M. vanbaalenii PYR-1 | Mvan_4107 | - | 0.0 | 63.10% (859) | HAD family hydrolase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2029|M.bovis_AF2122/97 MRCGIVVNVTGPPPTIDRRYHDAVIVGLDNVVDKATRVHAAAWTKFLDDY
Rv2006|M.tuberculosis_H37Rv MRCGIVVNVTGPPPTIDRRYHDAVIVGLDNVVDKATRVHAAAWTKFLDDY
MSMEG_3954|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_2257|M.marinum_M ----------MKSFTIDPRRHDGVIFVLD---------------------
TH_1155|M.thermoresistible__bu --------------------------------------------------
Mvan_4107|M.vanbaalenii_PYR-1 ---------MKLPVTIDPRYHDAVLLDLD---------------------
Mflv_4989|M.gilvum_PYR-GCK -----------MPVFIDPRHHDAVIFEVD---------------------
MLBr_00392|M.leprae_Br4923 --------------------------------------------------
MUL_0906|M.ulcerans_Agy99 --------------------------------------------------
MAV_4352|M.avium_104 --------------------------------------------------
Mb2029|M.bovis_AF2122/97 LTRRPQRTGEDHCPLTHDDYRRFLAGKPDSVADFLAARGIRLPPGSPTDL
Rv2006|M.tuberculosis_H37Rv LTRRPQRTGEDHCPLTHDDYRRFLAGKPDGVADFLAARGIRLPPGSPTDL
MSMEG_3954|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_2257|M.marinum_M --------------------------------------------------
TH_1155|M.thermoresistible__bu --------------------------------------------------
Mvan_4107|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_4989|M.gilvum_PYR-GCK --------------------------------------------------
MLBr_00392|M.leprae_Br4923 --------------------------------------------------
MUL_0906|M.ulcerans_Agy99 --------------------------------------------------
MAV_4352|M.avium_104 --------------------------------------------------
Mb2029|M.bovis_AF2122/97 TDDTVYGLQNLERQTFLQLLNTGVPEGKSIASFARRLQVAGVRVAAHTSH
Rv2006|M.tuberculosis_H37Rv TDDTVYGLQNLERQTFLQLLNTGVPEGKSIASFARRLQVAGVRVAAHTSH
MSMEG_3954|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_2257|M.marinum_M -----------------GDGHEQS-IWEPTVALARKLWQVGVGTAVYSPT
TH_1155|M.thermoresistible__bu --------------------------------------------------
Mvan_4107|M.vanbaalenii_PYR-1 -----------------GALTSEAPLFGPTVDLARKLQSIGVAAAAYSSN
Mflv_4989|M.gilvum_PYR-GCK -----------------DPVADEVALSASQGDLARRLTAAGIGVGCAES-
MLBr_00392|M.leprae_Br4923 --------------------------------------------------
MUL_0906|M.ulcerans_Agy99 --------------------------------------------------
MAV_4352|M.avium_104 --------------------------------------------------
Mb2029|M.bovis_AF2122/97 RNYGHTLDATGLAEVFAVFVDGAVTAELGLPAEPNPAGLIETAKRLGANP
Rv2006|M.tuberculosis_H37Rv RNYGHTLDATGLAEVFAVFVDGAVTAELGLPAEPNPAGLIETAKRLGANP
MSMEG_3954|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_2257|M.marinum_M DESVRVLDAAGLSEPEQVSAP----PQASR-AKPYCVGLSAAAAKLGAAV
TH_1155|M.thermoresistible__bu --------------------------------------------------
Mvan_4107|M.vanbaalenii_PYR-1 GQCRQALKAAGIDDLFGVCIDGMEGDRGTA-EKPDPAVLLEAARRIGARP
Mflv_4989|M.gilvum_PYR-GCK ------------------------------------AMLRETARRLGVHP
MLBr_00392|M.leprae_Br4923 --------------------------------------------------
MUL_0906|M.ulcerans_Agy99 --------------------------------------------------
MAV_4352|M.avium_104 --------------------------------------------------
Mb2029|M.bovis_AF2122/97 GRCVVIDSCQTGLRAGRNGGFALVIAVDAHGDAENLLSSGADAVVADLAA
Rv2006|M.tuberculosis_H37Rv GRCVVIDSCQTGLRAGRNGGFALVIAVDAHGDAENLLSSGADAVVADLAA
MSMEG_3954|M.smegmatis_MC2_155 --------------------------------MEHHTDAAQDDVVTD---
MMAR_2257|M.marinum_M QRLAVVAGMDGGVEAARECGFAFVIGFDRDGRAEELLRRGADVVAADLAE
TH_1155|M.thermoresistible__bu --------------------------------------------------
Mvan_4107|M.vanbaalenii_PYR-1 QRCVVVENSAAGVAAGRAGGFALVVGIDGTEVADELTRHGADVVLAGLAD
Mflv_4989|M.gilvum_PYR-GCK GRCVVVAGGEAGVRTARAGGFALIVGIDRAERAEDLRSCGADVVVPDLVA
MLBr_00392|M.leprae_Br4923 --------------------------------------------------
MUL_0906|M.ulcerans_Agy99 --------------------------------------------------
MAV_4352|M.avium_104 --------------------------------------------------
Mb2029|M.bovis_AF2122/97 VTVGSGDAAISTIPDALQVYSQLKRLLTGRRPAVFLDFDGTLSDIVERPE
Rv2006|M.tuberculosis_H37Rv VTVGSGDAAISTIPDALQVYSQLKRLLTGRRPAVFLDFDGTLSDIVERPE
MSMEG_3954|M.smegmatis_MC2_155 ---DEDRRPIADLPDALDHFDEIRDLLAFRNPAS----------------
MMAR_2257|M.marinum_M VTVRTGDERLSQCPNALDSYGQVIGMVAGRQLFVCMDYDGTLSEIVSEPD
TH_1155|M.thermoresistible__bu ------------LSNALASYGLLIGIVANRQPVVFCRFDGAL----ADRD
Mvan_4107|M.vanbaalenii_PYR-1 IAVRTGDRRISELPNALASYGQLIGITSARESMLFLDYDGTLSPIVSDPA
Mflv_4989|M.gilvum_PYR-GCK VTVRDGYRRMSELADALQSYGEIVPLAETRTPVVLLDFDGTLSDIVGDPD
MLBr_00392|M.leprae_Br4923 --------------------------------------------------
MUL_0906|M.ulcerans_Agy99 --------------------------------------------------
MAV_4352|M.avium_104 --------------------------------------------------
Mb2029|M.bovis_AF2122/97 AATLVDGAAEALRALAAQCPVAVISGRDLADVRNRVKVDGLWLAGSHGFE
Rv2006|M.tuberculosis_H37Rv AATLVDGAAEALRALAAQCPVAVISGRDLADVRNRVKVDGLWLAGSHGFE
MSMEG_3954|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_2257|M.marinum_M AATLVDGAAEALAHLSTQCPVAILSGRDLTDIRDRVGVPGIWYAGSHGFE
TH_1155|M.thermoresistible__bu TATLVDGAAAALRKLASLCPVAVISGREVSELRARVGVDGLWYAGGHGRE
Mvan_4107|M.vanbaalenii_PYR-1 AARLVEGADEALELVSKVCPVAILSGRDLADVSARVGTPGVWYAGSHGFE
Mflv_4989|M.gilvum_PYR-GCK TAALVPGARSVLDALAARCPVAVVSGRALADIRDRIGVPGIWYAGSHGFE
MLBr_00392|M.leprae_Br4923 --------------------------------------------------
MUL_0906|M.ulcerans_Agy99 --------------------------------------------------
MAV_4352|M.avium_104 --------------------------------------------------
Mb2029|M.bovis_AF2122/97 LVAPDGSHHQNAAATAAIDGLAEAAAQLADALREIAGAVVEHKRFAVAVH
Rv2006|M.tuberculosis_H37Rv LVAPDGSHHQNAAATAAIDGLAEAAAQLADALREIAGAVVEHKRFAVAVH
MSMEG_3954|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_2257|M.marinum_M LIAPDGTHHQHEAAAAAVDVLASAAKDLRHELAQIPGVSVEHKRFGVAVH
TH_1155|M.thermoresistible__bu VVAPDGSHHRFDG-------------------------------------
Mvan_4107|M.vanbaalenii_PYR-1 LTSPDGAYHCNDAAAVFVPVLEEAAAELNKTLAQIAGVRVEHKRFAVAVH
Mflv_4989|M.gilvum_PYR-GCK LCSPDGGIQENEAGLEIVRVLAGALAEVRERVGAVDGVLIEDKRFSIAVH
MLBr_00392|M.leprae_Br4923 --------------------------------------------------
MUL_0906|M.ulcerans_Agy99 --------------------------------------------------
MAV_4352|M.avium_104 --------------------------------------------------
Mb2029|M.bovis_AF2122/97 YRNVADDSVDNLIAAVRRLGHAAGLRVTTGRKVVELRPDIAWDKGKALDW
Rv2006|M.tuberculosis_H37Rv YRNVADDSVDNLIAAVRRLGHAAGLRVTTGRKVVELRPDIAWDKGKALDW
MSMEG_3954|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_2257|M.marinum_M YRNVAREHVAQVIATTHRYRREYGLRVTSGRKVVELRPDIDWDKGAALAW
TH_1155|M.thermoresistible__bu ---------------------------------------TDWDPGAALTS
Mvan_4107|M.vanbaalenii_PYR-1 YREVAPEQVSEIVSATHQLGARRGLRVTSGRMLVELRPDLDWDKGTTLAW
Mflv_4989|M.gilvum_PYR-GCK YRNVAAESVDEVVTAVRNIAQCNGLRADGGRRVVELKPDTGWHKGRAVEW
MLBr_00392|M.leprae_Br4923 --------------------------------------------------
MUL_0906|M.ulcerans_Agy99 --------------------------------------------------
MAV_4352|M.avium_104 --------------------------------------------------
Mb2029|M.bovis_AF2122/97 IGERLGPAEVGPDLRLPIYIGDDLTDEDAFDAVRFTGVGIVVR-HNEHGD
Rv2006|M.tuberculosis_H37Rv IGERLGPAEVGPDLRLPIYIGDDLTDEDAFDAVRFTGVGIVVR-HNEHGD
MSMEG_3954|M.smegmatis_MC2_155 ---------------LPVFIG-NPADDSAFRTVRRDGIGIVVVTHAEDEK
MMAR_2257|M.marinum_M IRSLIFE----DSRVLPMYVGDDLTDEDAFDALRFSGVGIVVR-HDEDGD
TH_1155|M.thermoresistible__bu IRARMGR----PEPVLPIYVGSELADEAAFDVLRLDGVSVVVH-HLGAAD
Mvan_4107|M.vanbaalenii_PYR-1 IRDRIDP----SGSLLPIYIGDDLTDEDAFDAVRFDGIGIVVG-HDEDGD
Mflv_4989|M.gilvum_PYR-GCK ILDRIDG----DELLLPVYIGDDLTDEDGFDAVRLRGIGVAVR-SAESGD
MLBr_00392|M.leprae_Br4923 --------------------------------------------------
MUL_0906|M.ulcerans_Agy99 --------------------------------------------------
MAV_4352|M.avium_104 --------------------------------------------------
Mb2029|M.bovis_AF2122/97 RRSAATFRLECPYTVCQFLSQLACDLQEAVQHDDP-WTLVFHGYDPGQER
Rv2006|M.tuberculosis_H37Rv RRSAATFRLECPYTVCQFLSQLACDLQEAVQHDDP-WTLVFHGYDPGQER
MSMEG_3954|M.smegmatis_MC2_155 RSTTATFRLDSPGAAATFRHRLAQEADRPTSIDPG-WVLTFDGYDPANER
MMAR_2257|M.marinum_M RPTAANFTLRNPNEVRDFVRRGAGWLAHAHETQSRGWTFTFEGYDPPNEK
TH_1155|M.thermoresistible__bu RPTGAQFRLDGAEEVCEFLRRGGNWIAYQRQTSNEAWTFSYRGYDPRQEK
Mvan_4107|M.vanbaalenii_PYR-1 RKTAANFTLQSPEQVREFIQRGSRWLAYKHQVSGEAWDYVFDGYDPQNEK
Mflv_4989|M.gilvum_PYR-GCK RRSAARFALDSPAAVCAFLARLSDQLAVEQDLTNDPWTLTFGGYLPEDER
MLBr_00392|M.leprae_Br4923 -------------------------MITEEAFPVEPWQIRETRLDLNLLA
MUL_0906|M.ulcerans_Agy99 --------------------------------------------------
MAV_4352|M.avium_104 -------------------------MIADESFPVDPWHVRETQLNLNLLA
Mb2029|M.bovis_AF2122/97 LREALCAVGNGYLGSRGCAPESAES--EAHYPGTYVAGVYNQLTDHIEGC
Rv2006|M.tuberculosis_H37Rv LREALCAVGNGYLGSRGCAPESAES--EAHYPGTYVAGVYNQLTDHIEGC
MSMEG_3954|M.smegmatis_MC2_155 FREALCTLGNGYFATRGCAPEAPAG--RFHYPGTYVAGIYNRLTDEIAGH
MMAR_2257|M.marinum_M LREALCTVGNGYFATRGAAPESKAG--QVHYPGTYAGGVFNRLDDLIGGT
TH_1155|M.thermoresistible__bu LREALCTVGNGYFATRGAAPEARAG--QVHYPGTYAAGVFNRLDDVVDGR
Mvan_4107|M.vanbaalenii_PYR-1 LREALCTVGNGYFATRGAAPESKAG--QVHYPGTYAAGVYNRLVDNVSGT
Mflv_4989|M.gilvum_PYR-GCK LREALCTLGNGYLATRGAAPECDAS--RLHYPATYVAGIYNRLFDEIAGT
MLBr_00392|M.leprae_Br4923 QSESLFALSNGHIGLRGNLDEGEPYGLPGTYLNSFYEIRPLPYAEAGYGY
MUL_0906|M.ulcerans_Agy99 --------------------------------------------------
MAV_4352|M.avium_104 QSESLFTLSNGHIGLRGNLDEGEPYGLPGTYLNSFYEIRPLPYAEAGYGY
Mb2029|M.bovis_AF2122/97 TVDNESLVNLPNWLSLTFRIDGGAWFNVDTVELLSYRQTFDLRRATLTRS
Rv2006|M.tuberculosis_H37Rv TVDNESLVNLPNWLSLTFRIDGGAWFNVDTVELLSYRQTFDLRRATLTRS
MSMEG_3954|M.smegmatis_MC2_155 RTDNESLVNLPNWLALTFRFDDGPWLDVDDTDLQSYQQTLDLRRGVLTRQ
MMAR_2257|M.marinum_M RTAHESLVNLPNWLPLTFRIDGGDWFDVDAVTLLSYRQTLDLRGAVLTRE
TH_1155|M.thermoresistible__bu VTAHESMVNLPNWLPLTFRIEGGPWFDVDAVTLLDYRQTLDLRGAVLTRE
Mvan_4107|M.vanbaalenii_PYR-1 EIDNESLVNLPNWLALTFRVDHGDWFDIDAVTVLSYRQTLDLRGAVLTRQ
Mflv_4989|M.gilvum_PYR-GCK TVDNESLVNLPNWLPVTFRVDGGAWFDIDAVEFTSYVTTLDLRRATLTRE
MLBr_00392|M.leprae_Br4923 PEAGQTVVDVTNGKILRLFVED-EPFDVRYGEVIFHERVLDLCAGTLTRR
MUL_0906|M.ulcerans_Agy99 --------------------------------------------------
MAV_4352|M.avium_104 PEAGQTLVDVTNGKIIRLLVED-EPFDVRYGELLSHERTLDLRGGTLTRS
Mb2029|M.bovis_AF2122/97 LRFRDAGGRVTTMTQERFASMNRPNLVALQTRIESENWSGTVDFRSLVDG
Rv2006|M.tuberculosis_H37Rv LRFRDAGGRVTTMTQERFASMNRPNLVALQTRIESENWSGTVDFRSLVDG
MSMEG_3954|M.smegmatis_MC2_155 FRFCDKAGRVATVTQHRLVAMHLPHLAMLQTMVTAENFSGTVEFRSEIDG
MMAR_2257|M.marinum_M LTFRDDAGRTSSVTQHRFVSMNQAHVAALQTTIVGHDWSGTIEIRSTIDG
TH_1155|M.thermoresistible__bu LRFRDNAGRTTSVTQQRFVAMHTAHIAALETTLVAEDWSGTVDVRSTLDG
Mvan_4107|M.vanbaalenii_PYR-1 VRFRDHAGRTSSLTQRRFVAMHLPHAGALETTVVAEDWSGTIEFRSTVDG
Mflv_4989|M.gilvum_PYR-GCK FVMRDQAGRITRIRQRRLVAMHRPHVAAMATTVRAENWSGRLQLRSVLDG
MLBr_00392|M.leprae_Br4923 ANWRSPADKQVKVVSTRLVSLAHRSVAAIEYVVEALDKFVRVTVQSELVS
MUL_0906|M.ulcerans_Agy99 --------------------------------MEAVDDFARITVQSELVT
MAV_4352|M.avium_104 AYWRSPAGKEVKVVSTRLVSLAQRGVAAIEYVVQAVGDFVRVTVQSELVT
: . . : .:* :
Mb2029|M.bovis_AF2122/97 GVHNTLVDRYRQLSSQHLT-TAEIEVLAD--SVLLRTQTSQSGIAIAVAA
Rv2006|M.tuberculosis_H37Rv GVHNTLVDRYRQLSSQHLT-TAEIEVLAD--SVLLRTQTSQSGIAIAVAA
MSMEG_3954|M.smegmatis_MC2_155 AVTNSLVERYRDLSNVHLVGHEKRSLTAD--SLLLTAHTCQSHIRVAVAL
MMAR_2257|M.marinum_M NVRNSGVERYRNLASNHLQGLQKAVLSEN--SVSMAVETTQSKIPVAVAA
TH_1155|M.thermoresistible__bu DVRNGLVERYRDLRGDHLESLGKSALTGD--SVLLSVRTNQSRIPIAMAA
Mvan_4107|M.vanbaalenii_PYR-1 NVTNSLVERYRDLANEHLDSADTQELSNN--SVLLTMQTNQSRIPIAMAA
Mflv_4989|M.gilvum_PYR-GCK GVENLGVERYRALSSRHLTVDAMRELSRD--AVLLQTHTGESQIQIAVAA
MLBr_00392|M.leprae_Br4923 NEDQPETSGDPRVSAILDNPLEAVEHEATERGGLLMHRTRASSLMMAAGM
MUL_0906|M.ulcerans_Agy99 NEDQPETSDDPRVSAILEHPLQAVDHENTECGALLMHRTRSSALMMAAAM
MAV_4352|M.avium_104 NEDQPQTSGDPRVSAILENPLEEVDHENTDTGALLIHRTRSSALMMAAGM
: .. : . : .* * : :* .
Mb2029|M.bovis_AF2122/97 RSTLWRDGQRVDAQYRVARDTNRGGHDIQVTLSAGQSVTLEKVATIFTS-
Rv2006|M.tuberculosis_H37Rv RSTLWRDGQRVDAQYRVARDTNRGGHDIQVTLSAGQSVTLEKVATIFTS-
MSMEG_3954|M.smegmatis_MC2_155 RNTVWRGDSPARADYTLVDDRRRAGHVISCYIEAGQPVTLEKAVSVATS-
MMAR_2257|M.marinum_M RTSLWRADEPVAATYRLLDEEFEIGHEIFTEAKLGQPLTVEKIVTLVSG-
TH_1155|M.thermoresistible__bu RTTAWRDGDPVSAGYRLVDEESEIGHQITTGLSRGQRLTVEKVVALSTG-
Mvan_4107|M.vanbaalenii_PYR-1 RNTVWRDGEPVPAAFALFDQGAEIGHDIAVHLSAGDAVTLEKVVTVYTG-
Mflv_4989|M.gilvum_PYR-GCK RHRVT-GGEPESVDQRVFRDDCRIGHDIEVVVTAGQAVTLEKVIAVYTG-
MLBr_00392|M.leprae_Br4923 DHEVEVPGRVEITTDARPDLAR---TTVICGLRPGQKLRIVKYLAYGWSS
MUL_0906|M.ulcerans_Agy99 DHEVEVPGRVEITTDARPDLAR---TTVICGLRPGQKLRIVKYLAYGWSS
MAV_4352|M.avium_104 DHEVEVPGRVEVSTDSRADLAR---TTVICGLRAGQKLRIVKYLAYGWSS
. : *: : : * : .
Mb2029|M.bovis_AF2122/97 -RDAATLTAAISAQRCLGEAGRYAELCQQHVRAWARLWERCAIDLTGNTE
Rv2006|M.tuberculosis_H37Rv -RDAATLTAAISAQRCLGEAGRYAELCQQHVRAWARLWERCAIDLTGNTE
MSMEG_3954|M.smegmatis_MC2_155 -RDHATCEAANEATRRLQWVDRYHDVQQAHTTAWGQLWERFDVDIGGRTD
MMAR_2257|M.marinum_M -LDVATSHPAIGAERRLGRQGRFAEICDAHRIAWSHLWERLSIEFSNHTE
TH_1155|M.thermoresistible__bu -RDVGSSEPSESAERILERQGRFGEIRAAHTVAWAHLWRRLSIEFEDHTD
Mvan_4107|M.vanbaalenii_PYR-1 -RDVAISEPGVNAQRWVTRLGRFDELLDGHRTAWTHLWERLSIDFDDFTD
Mflv_4989|M.gilvum_PYR-GCK -RDHGMSGPVTAAEREIAGADTFDRLEDGHRLAWAHLWERFNIDMGHDPN
MLBr_00392|M.leprae_Br4923 LRSRPALHDQATAALHTARYSGWQGLLDAQRAYLNEFWDSADVEVEGDPE
MUL_0906|M.ulcerans_Agy99 LRSRPALRDQVAGALHGARYSGWQGLIDTQRSYLDEFWDSADVEVEGDPE
MAV_4352|M.avium_104 MRSRPALRDQVAAALHSARYTGWPGLLESQRKYLDNFWDCADVEVEGDPE
. . : : : .:* ::. .:
Mb2029|M.bovis_AF2122/97 ELRLVRLHLLHLLQTISPHTAELDAGVPARGLNGEAYRGHVFWD-ALFVA
Rv2006|M.tuberculosis_H37Rv ELRLVRLHLLHLLQTISPHTAELDAGVPARGLNGEAYRGHVFWD-ALFVA
MSMEG_3954|M.smegmatis_MC2_155 ELRTVRLHLLHTLQTLSPHVRDLDIGVPARGLTGEAYRGHIFWD-ELFVA
MMAR_2257|M.marinum_M ELRVLRLHLLHLLQTVSYNSADLDVGVPARGLHGEAYRGHIFWD-ELFIF
TH_1155|M.thermoresistible__bu ELRVMRLHLLHLLQTVSPHSADLDIGPPARGLHGEAYRGHIFWD-ELFIF
Mvan_4107|M.vanbaalenii_PYR-1 ELRILRLHLLHLLQTVSLNTADLDAGVPARGLHGEAYRGHIFWD-ELFIF
Mflv_4989|M.gilvum_PYR-GCK LLRLVRLHQLHLLQTLSPHTADLDVGVPARGLHGEAYRGHVFWD-ELFVF
MLBr_00392|M.leprae_Br4923 SQQAVRFGLFHLLQAS---ARAERRAIPSKGLTGTGYDGHAFWDTEGFVL
MUL_0906|M.ulcerans_Agy99 CQQAVRFGLFHLLQAS---ARAERRAIPSKGLTGTGYDGHAFWDSEGFVL
MAV_4352|M.avium_104 SQQAVRFGLFHLLQAS---ARAERRAIAAKGLTGTGYDGHAFWDTEGYVL
: :*: :* **: . .::** * .* ** *** ::
Mb2029|M.bovis_AF2122/97 PVLSLRMPKVARSLLDYRYRRLPAARRAAHRAGHLGAMYPWQSGSDGSEV
Rv2006|M.tuberculosis_H37Rv PVLSLRMPKVARSLLDYRYRRLPAARRAAHRAGHLGAMYPWQSGSDGSEV
MSMEG_3954|M.smegmatis_MC2_155 PVVSLRRPALTRALLAYRHRRLPEARRAARDAGFTGAMFPWQSGSNGREE
MMAR_2257|M.marinum_M PVLNLRLPAVTRSLLLYRYRRLLEAQRAAKLAGYRGAMYPWQSGSDGREE
TH_1155|M.thermoresistible__bu PVLNLRFPMITRSLLQYRYRRLPEARRAARLAGYRGAIFPWQSGSDGREE
Mvan_4107|M.vanbaalenii_PYR-1 PVLNLRAPMITRSLLGYRYRRLPEARHAARAAGHSGAMFPWQSGSDGREE
Mflv_4989|M.gilvum_PYR-GCK PVLNMRLPKVTRSLLLYRYRRLPEARRAAAEAGYAGAMFPWQSGSDGREE
MLBr_00392|M.leprae_Br4923 PVLTYTAPHAVADALRWRASTLQLAKDRAAELGLDGASFCWR--------
MUL_0906|M.ulcerans_Agy99 PVLTYTAPHAVADALRWRASTLDLAKERAAELGLDGASFPWR--------
MAV_4352|M.avium_104 PVLTYTAPHTVADALRWRASTLDLAKERAAELGLEGAAFPWR--------
**:. * . * :* * *: * * ** : *:
Mb2029|M.bovis_AF2122/97 SQQLHLNPRSGRWTPDPSDRAHHVGLAVAYNAWHYYQVTGDRQYLVDCGA
Rv2006|M.tuberculosis_H37Rv SQQLHLNPRSGRWTPDPSDRAHHVGLAVAYNAWHYYQVTGDRQYLVDCGA
MSMEG_3954|M.smegmatis_MC2_155 SPALHLNPRSGRWNPDPSALAHHVGLAVAYNIWQYYQVTDDLEYLIDYGA
MMAR_2257|M.marinum_M SPEQHLNPRSGRWIPDASHRAHHIGIAVAYNVWQFYQVTGDLAFMIDYGT
TH_1155|M.thermoresistible__bu SPELHLNPRSGRWNSDPSHRAHHIGIAIAYNVWQFYQVTGDLAYLIDHGA
Mvan_4107|M.vanbaalenii_PYR-1 SQRLHLNPRSGRWNPDASARAHHIGIAVAYSAWKFYQVTGDLAYLIDYGA
Mflv_4989|M.gilvum_PYR-GCK SQRLHLNPRSGRWNPDASARAHHVGLAIAFNIWQHYQVTGDIGFLIDYGA
MLBr_00392|M.leprae_Br4923 --TIRGQECSAYWP--AGTAAWHINADIAMAFERYRIVTGDHSLEEECGL
MUL_0906|M.ulcerans_Agy99 --TIRGEECSAYWP--AGTAAWQINADIAMAFERYRTVTCDHSLEKDCGL
MAV_4352|M.avium_104 --TIRGQECSAYWP--AGTAAWHINADIAMAFERYRIVTGDDDLEAECGL
: : *. * .. * ::. :* :. ** * : *
Mb2029|M.bovis_AF2122/97 ELLVEIARFWVGLAKLDDSRGRYLIRGVIGPDEFHSGYPGNEYDGIDNNA
Rv2006|M.tuberculosis_H37Rv ELLVEIARFWVGLAKLDDSRGRYLIRGVIGPDEFHSGYPGNEYDGIDNNA
MSMEG_3954|M.smegmatis_MC2_155 ETLLEIARFWAGLALFSRERGRYVIPGVIGPDEFHTGYPGRLYDGIDNNA
MMAR_2257|M.marinum_M EMMAEIARFWVSRATYDAERDRYHIKGVIGPDEFHSGYPDRPYDGVDDNA
TH_1155|M.thermoresistible__bu ELLVEIARFWVSRAEFDTRRGRYRIRGVIGPDEFHAGYPDRPFDGVDDNA
Mvan_4107|M.vanbaalenii_PYR-1 ELIAEVARFFVSLASYDEDRERFGIKGVIGPDEFHSGYPEAPYDGIDNNA
Mflv_4989|M.gilvum_PYR-GCK EMLVEITKFWVSAANLDPHRDRYVIRGVIGPDEFHSGYPGREYDGVDNNA
MLBr_00392|M.leprae_Br4923 AVLIETARLWLSLGHHDR-HGVWHLDGVTGPDEYTA--------VVRDNV
MUL_0906|M.ulcerans_Agy99 AVLIETARLWISLGHHDR-HGIWHLDGVTGPDEYTA--------IVRDNV
MAV_4352|M.avium_104 PVLVETARLWLSLGHHDR-HGVWHLDGVTGPDEYTA--------VVRDNV
: * :::: . . . : : : ** ****: : : :*.
Mb2029|M.bovis_AF2122/97 YTNVMAVWVILRAMEALDLLPLTDRRHLIEKLGLTTQERDQWDDVSRRMF
Rv2006|M.tuberculosis_H37Rv YTNVMAVWVILRAMEALDLLPLTDRRHLIEKLGLTTQERDQWDDVSRRMF
MSMEG_3954|M.smegmatis_MC2_155 YTNVMAVWVILRALDALDAMPLADRTALLERLGLHGDELDKWEDVSHRMF
MMAR_2257|M.marinum_M YTNVMAAWVILRAIDALLLMPLPNRLDLYEKLALTEEELAQWDHVSRRMF
TH_1155|M.thermoresistible__bu YTNVMAVWVILRALEALNLIPLPNRIDVREKLNLTAAELAQWDDVSRRMY
Mvan_4107|M.vanbaalenii_PYR-1 YTNVMAVWVIMRAIDALNLLPLPNRLDLLEALGLHNEELAHWDDVSRRMY
Mflv_4989|M.gilvum_PYR-GCK YTNLMAVWVIVRTLEALERLPLSYRLALLETVGVGDEDLAHWEDVSRRMF
MLBr_00392|M.leprae_Br4923 FTNLMAASNLITAADACLRQPE-----AAKAMGVTTEEMAAWRDAADAAN
MUL_0906|M.ulcerans_Agy99 FTNLMAAHNLITAADACLRHPE-----AAQDMGVTTEGMAAWRDAADAVN
MAV_4352|M.avium_104 FTNLMAAHNLRVAAEACNRHPD-----GAKALGVTTEETAAWRDAADAVK
:**:**. : : :* * : : : * ..:
Mb2029|M.bovis_AF2122/97 VPFHD--GVISQFEGYSELAELDWDHYRHRYGNIQRLDRILEAEGDSVNN
Rv2006|M.tuberculosis_H37Rv VPFHD--GVISQFEGYSELAELDWDHYRHRYGNIQRLDRILEAEGDSVNN
MSMEG_3954|M.smegmatis_MC2_155 VPFHN--GVISQFEGYESLVELDWDRYRHEYGNIQRLDRILEAENDNVNR
MMAR_2257|M.marinum_M VPFHD--GVISQFDGYEQLAELDWDAYRQRYGNIQRLDRILEAEDDDVNR
TH_1155|M.thermoresistible__bu VPFHD--GIISQFEGYGELAELDWDGYRRRYGNIQRLDRILEAEGDDVNR
Mvan_4107|M.vanbaalenii_PYR-1 VPFHD--GVISQFEGYGDLADLDWDRLRRQYGNIQRLDRILEAENDDVNR
Mflv_4989|M.gilvum_PYR-GCK VPFHD--GVITQFEGYDRLRELDWEAYRNRYDDLQRLDRILEAEGDSVNN
MLBr_00392|M.leprae_Br4923 IPYDDELGVHQQCEGFTTFAEWDFEAN-------TTYPLFLHEAYVRLYP
MUL_0906|M.ulcerans_Agy99 IPYDEELGVHQQCEGFTTLAEWDFETN-------TTYPLLLHEAYVRLYP
MAV_4352|M.avium_104 IPYDSGLGVHQQCEGFTTFAEWDFEHN-------TTYPLLLHEAYVRLYP
:*:.. *: * :*: : : *:: :*. :
Mb2029|M.bovis_AF2122/97 YQASKQADALMLLYLLSSDELIGLLARLGYRFAPTQIPGTVDYYLARTSD
Rv2006|M.tuberculosis_H37Rv YQASKQADALMLLYLLSSDELIGLLARLGYRFAPTQIPGTVDYYLARTSD
MSMEG_3954|M.smegmatis_MC2_155 YKASKQADVLMLFYLLSADEIRELLARLGYRFTPKQIPETVDYYLSRTSH
MMAR_2257|M.marinum_M YRASKQADALMLLYLLSADELGELLDRLGYHMERDQIPEMVDYYMARTSH
TH_1155|M.thermoresistible__bu YKASKQADALMLLYLLSADELRELLGHLGYRFTAEQIPGMVDYYLARTSH
Mvan_4107|M.vanbaalenii_PYR-1 YKASKQADALMLLYLLSADELREILDRLGYRFLPEQVPKMVDYYLARTSH
Mflv_4989|M.gilvum_PYR-GCK YRAGKQADTLMLFYLLSADELYELFDRLGYNFAPEQIPATIDYYQKRTSH
MLBr_00392|M.leprae_Br4923 AQVIKQADLVLAMQWQS------------HAFTPEQKARNVDYYERRMVR
MUL_0906|M.ulcerans_Agy99 TQVIKQAHLVLAMQWQS------------HAFTAEQKARNVDYYERRMVR
MAV_4352|M.avium_104 AQVIKQADLVLAMHWQS------------HAFTPEQKARNVDYYEPRMVR
:. ***. :: : * : : * . :*** *
Mb2029|M.bovis_AF2122/97 GSTLSAVVHAWVLARA-NRSNAMEYFRQVLRSDIADVQGGTTQEGIHLAA
Rv2006|M.tuberculosis_H37Rv GSTLSAVVHAWVLARA-NRSNAMEYFRQVLRSDIADVQGGTTQEGIHLAA
MSMEG_3954|M.smegmatis_MC2_155 GSTLSAVVHSWVLARG-HREQAMEFFVQALNSDVADIQGGTTAEGIHLAA
MMAR_2257|M.marinum_M GSTLSAAVHGWVLARA-NRDRALEFFQQVLESDVADIQGGTTAEGVHLAA
TH_1155|M.thermoresistible__bu GSTLSAVVHAWVLARA-NRDRAMEYFERVLKSDVADIQGGTTAEGIHLAA
Mvan_4107|M.vanbaalenii_PYR-1 GSTLSGVVHTWVLARA-NRNRALEFFQQALKSDVSDIQGGTTSEGIHLAA
Mflv_4989|M.gilvum_PYR-GCK GSTLSAVVHSWVLARG-DRREAMHYFRRVLASDVVDIQRGTTAEGIHLAA
MLBr_00392|M.leprae_Br4923 DSSLSACTQAVMCAEVGHLELAHDYAYEAALIDLRDLHR-NTRDGLHMAS
MUL_0906|M.ulcerans_Agy99 DSSLSACTQAVMCADVGHLELAHDYAYEAALIDLRDLHR-NTRDGLHMAS
MAV_4352|M.avium_104 DSSLSACTQAVMCAEVGHLELAHDYAYEAALIDLRDLHH-NTRDGLHMAS
.*:**. .: : * . * .: .. *: *:: .* :*:*:*:
Mb2029|M.bovis_AF2122/97 MAGSIDLPQRCYSGLELRDDRLVLSPQWPEALGPLEFPFVYRRHQLSLRI
Rv2006|M.tuberculosis_H37Rv MAGSIDLLQRCYSGLELRDDRLVLSPQWPEALGPLEFPFVYRRHQLSLRI
MSMEG_3954|M.smegmatis_MC2_155 MAGSVDLLQRCFTGLETRGDRLVLGPCWPEALGVLSFRMYYRGHNLHLRV
MMAR_2257|M.marinum_M MAGSVDFVQRCFTGLEIRADRIVLSPHWPEYLGALGFPIHYRGNHLHLRV
TH_1155|M.thermoresistible__bu MAGSVDLVQRCFTGLETRSDRIVLSPNWPESLGALGFPIRYRGHQMYVRV
Mvan_4107|M.vanbaalenii_PYR-1 MAGTVDLMQRCFTGLETRSNRIILSPYWPESLGVLAIPIHYRGLHLHLRV
Mflv_4989|M.gilvum_PYR-GCK MAGSIDLLQRCFTGLELRRDRIVVGPMWPEPLGRLAFTFRYRGHRLRLTV
MLBr_00392|M.leprae_Br4923 LAGAWTALVGGFGGLRDDEGILSIDPQLPHGISRLRFRLRWRGFRLTVDA
MUL_0906|M.ulcerans_Agy99 LAGAWTALVGGFGGLRDDEGILSIDPQLPDGISRLRFRLRWRGYRLTVDA
MAV_4352|M.avium_104 LAGAWTALVSGFGGLRDDEGVLSLDPQLPDGISRLRFRLRWRDFRVTVDV
:**: : **. . : :.* *. :. * : : :* .: :
Mb2029|M.bovis_AF2122/97 SGRSATLTAESGDAEPIEVECRGHVQRLRCGHTIEVGCSR----------
Rv2006|M.tuberculosis_H37Rv SGRSATLTAESGDAEPIEVECRGHVQRLRCGHTIEVGCSR----------
MSMEG_3954|M.smegmatis_MC2_155 SGRTASVISAIGSAAPITLECRGRTWQLCAGTTIDVG-------------
MMAR_2257|M.marinum_M SGKGAEISVEPRDVPPVEVECHGRVERLLPGSTVRFS-------------
TH_1155|M.thermoresistible__bu SGRGAEISVAPRDLPPVAVECNGRVQRLEPGTTVRFT-------------
Mvan_4107|M.vanbaalenii_PYR-1 SGKGVIISVDPRDAAGIEVECRGQVVQLMPGTTVRFPG------------
Mflv_4989|M.gilvum_PYR-GCK LGRSSTLSAEPSEASPILVECRGQAQTLVAGGTVEFTR------------
MLBr_00392|M.leprae_Br4923 RHADVTYTLRDGPGGELTIRHAGEHLTLKSDSPSTIAVRDRKPLLPPPSQ
MUL_0906|M.ulcerans_Agy99 NHSTVTFTLRDGPGAELTIRHAGKDLELSSTKPTTISVHKHKPLLPPPPQ
MAV_4352|M.avium_104 NHADVTYTLRDGPGGELTIQHAGAELELSTQSPTTVAVRPRKPLLPPPQQ
: :. * * . .
Mb2029|M.bovis_AF2122/97 ----------------------
Rv2006|M.tuberculosis_H37Rv ----------------------
MSMEG_3954|M.smegmatis_MC2_155 ----------------------
MMAR_2257|M.marinum_M ----------------------
TH_1155|M.thermoresistible__bu ----------------------
Mvan_4107|M.vanbaalenii_PYR-1 ----------------------
Mflv_4989|M.gilvum_PYR-GCK ----------------------
MLBr_00392|M.leprae_Br4923 PPGREPVSRRHKSLIISAAR--
MUL_0906|M.ulcerans_Agy99 PPGREPVHRRNMAAKVWASTAT
MAV_4352|M.avium_104 PPGREPTHRRAVSRSSPGQ---