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aa seq not available
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. thermoresistible (build 8) | TH_1155 | - | - | 100% (981) | trehalose 6-phosphate phosphorylase |
M. thermoresistible (build 8) | TH_2141 | - | 7e-47 | 26.93% (776) | CONSERVED HYPOTHETICAL PROTEIN |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb2029 | otsB1 | 0.0 | 58.79% (961) | trehalose-6-phosphate phosphatase OtsB1 |
M. gilvum PYR-GCK | Mflv_4989 | - | 0.0 | 53.63% (1061) | HAD family hydrolase |
M. tuberculosis H37Rv | Rv2006 | otsB1 | 0.0 | 58.79% (961) | trehalose-6-phosphate phosphatase OtsB1 |
M. leprae Br4923 | MLBr_00392 | - | 2e-47 | 27.00% (789) | putative sugar phosphorylase |
M. abscessus ATCC 19977 | - | - | - | - | - |
M. marinum M | MMAR_2257 | otsB1 | 0.0 | 69.30% (961) | trehalose-6-phosphate phosphatase OtsB1 |
M. avium 104 | MAV_4352 | - | 3e-51 | 28.44% (777) | glycoside hydrolase family protein 65, central catalytic |
M. smegmatis MC2 155 | MSMEG_3954 | - | 0.0 | 61.74% (860) | trehalose 6-phosphate phosphorylase |
M. ulcerans Agy99 | MUL_0906 | - | 5e-37 | 27.60% (558) | glycosyl hydrolase |
M. vanbaalenii PYR-1 | Mvan_4107 | - | 0.0 | 70.49% (881) | HAD family hydrolase |
CLUSTAL 2.0.9 multiple sequence alignment TH_1155|M.thermoresistible__bu -------------------------------------------------- MMAR_2257|M.marinum_M ----------MKSFTIDPRRHDGVIFVLD--------------------- Mvan_4107|M.vanbaalenii_PYR-1 ---------MKLPVTIDPRYHDAVLLDLD--------------------- Mb2029|M.bovis_AF2122/97 MRCGIVVNVTGPPPTIDRRYHDAVIVGLDNVVDKATRVHAAAWTKFLDDY Rv2006|M.tuberculosis_H37Rv MRCGIVVNVTGPPPTIDRRYHDAVIVGLDNVVDKATRVHAAAWTKFLDDY MSMEG_3954|M.smegmatis_MC2_155 -------------------------------------------------- Mflv_4989|M.gilvum_PYR-GCK -----------MPVFIDPRHHDAVIFEVD--------------------- MLBr_00392|M.leprae_Br4923 -------------------------------------------------- MUL_0906|M.ulcerans_Agy99 -------------------------------------------------- MAV_4352|M.avium_104 -------------------------------------------------- TH_1155|M.thermoresistible__bu -------------------------------------------------- MMAR_2257|M.marinum_M -------------------------------------------------- Mvan_4107|M.vanbaalenii_PYR-1 -------------------------------------------------- Mb2029|M.bovis_AF2122/97 LTRRPQRTGEDHCPLTHDDYRRFLAGKPDSVADFLAARGIRLPPGSPTDL Rv2006|M.tuberculosis_H37Rv LTRRPQRTGEDHCPLTHDDYRRFLAGKPDGVADFLAARGIRLPPGSPTDL MSMEG_3954|M.smegmatis_MC2_155 -------------------------------------------------- Mflv_4989|M.gilvum_PYR-GCK -------------------------------------------------- MLBr_00392|M.leprae_Br4923 -------------------------------------------------- MUL_0906|M.ulcerans_Agy99 -------------------------------------------------- MAV_4352|M.avium_104 -------------------------------------------------- TH_1155|M.thermoresistible__bu -------------------------------------------------- MMAR_2257|M.marinum_M -----------------GDGHEQS-IWEPTVALARKLWQVGVGTAVYSPT Mvan_4107|M.vanbaalenii_PYR-1 -----------------GALTSEAPLFGPTVDLARKLQSIGVAAAAYSSN Mb2029|M.bovis_AF2122/97 TDDTVYGLQNLERQTFLQLLNTGVPEGKSIASFARRLQVAGVRVAAHTSH Rv2006|M.tuberculosis_H37Rv TDDTVYGLQNLERQTFLQLLNTGVPEGKSIASFARRLQVAGVRVAAHTSH MSMEG_3954|M.smegmatis_MC2_155 -------------------------------------------------- Mflv_4989|M.gilvum_PYR-GCK -----------------DPVADEVALSASQGDLARRLTAAGIGVGCAES- MLBr_00392|M.leprae_Br4923 -------------------------------------------------- MUL_0906|M.ulcerans_Agy99 -------------------------------------------------- MAV_4352|M.avium_104 -------------------------------------------------- TH_1155|M.thermoresistible__bu -------------------------------------------------- MMAR_2257|M.marinum_M DESVRVLDAAGLSEPEQVSAP----PQASR-AKPYCVGLSAAAAKLGAAV Mvan_4107|M.vanbaalenii_PYR-1 GQCRQALKAAGIDDLFGVCIDGMEGDRGTA-EKPDPAVLLEAARRIGARP Mb2029|M.bovis_AF2122/97 RNYGHTLDATGLAEVFAVFVDGAVTAELGLPAEPNPAGLIETAKRLGANP Rv2006|M.tuberculosis_H37Rv RNYGHTLDATGLAEVFAVFVDGAVTAELGLPAEPNPAGLIETAKRLGANP MSMEG_3954|M.smegmatis_MC2_155 -------------------------------------------------- Mflv_4989|M.gilvum_PYR-GCK ------------------------------------AMLRETARRLGVHP MLBr_00392|M.leprae_Br4923 -------------------------------------------------- MUL_0906|M.ulcerans_Agy99 -------------------------------------------------- MAV_4352|M.avium_104 -------------------------------------------------- TH_1155|M.thermoresistible__bu -------------------------------------------------- MMAR_2257|M.marinum_M QRLAVVAGMDGGVEAARECGFAFVIGFDRDGRAEELLRRGADVVAADLAE Mvan_4107|M.vanbaalenii_PYR-1 QRCVVVENSAAGVAAGRAGGFALVVGIDGTEVADELTRHGADVVLAGLAD Mb2029|M.bovis_AF2122/97 GRCVVIDSCQTGLRAGRNGGFALVIAVDAHGDAENLLSSGADAVVADLAA Rv2006|M.tuberculosis_H37Rv GRCVVIDSCQTGLRAGRNGGFALVIAVDAHGDAENLLSSGADAVVADLAA MSMEG_3954|M.smegmatis_MC2_155 --------------------------------MEHHTDAAQDDVVTD--- Mflv_4989|M.gilvum_PYR-GCK GRCVVVAGGEAGVRTARAGGFALIVGIDRAERAEDLRSCGADVVVPDLVA MLBr_00392|M.leprae_Br4923 -------------------------------------------------- MUL_0906|M.ulcerans_Agy99 -------------------------------------------------- MAV_4352|M.avium_104 -------------------------------------------------- TH_1155|M.thermoresistible__bu ------------LSNALASYGLLIGIVANRQPVVFCRFDGAL----ADRD MMAR_2257|M.marinum_M VTVRTGDERLSQCPNALDSYGQVIGMVAGRQLFVCMDYDGTLSEIVSEPD Mvan_4107|M.vanbaalenii_PYR-1 IAVRTGDRRISELPNALASYGQLIGITSARESMLFLDYDGTLSPIVSDPA Mb2029|M.bovis_AF2122/97 VTVGSGDAAISTIPDALQVYSQLKRLLTGRRPAVFLDFDGTLSDIVERPE Rv2006|M.tuberculosis_H37Rv VTVGSGDAAISTIPDALQVYSQLKRLLTGRRPAVFLDFDGTLSDIVERPE MSMEG_3954|M.smegmatis_MC2_155 ---DEDRRPIADLPDALDHFDEIRDLLAFRNPAS---------------- Mflv_4989|M.gilvum_PYR-GCK VTVRDGYRRMSELADALQSYGEIVPLAETRTPVVLLDFDGTLSDIVGDPD MLBr_00392|M.leprae_Br4923 -------------------------------------------------- MUL_0906|M.ulcerans_Agy99 -------------------------------------------------- MAV_4352|M.avium_104 -------------------------------------------------- TH_1155|M.thermoresistible__bu TATLVDGAAAALRKLASLCPVAVISGREVSELRARVGVDGLWYAGGHGRE MMAR_2257|M.marinum_M AATLVDGAAEALAHLSTQCPVAILSGRDLTDIRDRVGVPGIWYAGSHGFE Mvan_4107|M.vanbaalenii_PYR-1 AARLVEGADEALELVSKVCPVAILSGRDLADVSARVGTPGVWYAGSHGFE Mb2029|M.bovis_AF2122/97 AATLVDGAAEALRALAAQCPVAVISGRDLADVRNRVKVDGLWLAGSHGFE Rv2006|M.tuberculosis_H37Rv AATLVDGAAEALRALAAQCPVAVISGRDLADVRNRVKVDGLWLAGSHGFE MSMEG_3954|M.smegmatis_MC2_155 -------------------------------------------------- Mflv_4989|M.gilvum_PYR-GCK TAALVPGARSVLDALAARCPVAVVSGRALADIRDRIGVPGIWYAGSHGFE MLBr_00392|M.leprae_Br4923 -------------------------------------------------- MUL_0906|M.ulcerans_Agy99 -------------------------------------------------- MAV_4352|M.avium_104 -------------------------------------------------- TH_1155|M.thermoresistible__bu VVAPDGSHHRFDG------------------------------------- MMAR_2257|M.marinum_M LIAPDGTHHQHEAAAAAVDVLASAAKDLRHELAQIPGVSVEHKRFGVAVH Mvan_4107|M.vanbaalenii_PYR-1 LTSPDGAYHCNDAAAVFVPVLEEAAAELNKTLAQIAGVRVEHKRFAVAVH Mb2029|M.bovis_AF2122/97 LVAPDGSHHQNAAATAAIDGLAEAAAQLADALREIAGAVVEHKRFAVAVH Rv2006|M.tuberculosis_H37Rv LVAPDGSHHQNAAATAAIDGLAEAAAQLADALREIAGAVVEHKRFAVAVH MSMEG_3954|M.smegmatis_MC2_155 -------------------------------------------------- Mflv_4989|M.gilvum_PYR-GCK LCSPDGGIQENEAGLEIVRVLAGALAEVRERVGAVDGVLIEDKRFSIAVH MLBr_00392|M.leprae_Br4923 -------------------------------------------------- MUL_0906|M.ulcerans_Agy99 -------------------------------------------------- MAV_4352|M.avium_104 -------------------------------------------------- TH_1155|M.thermoresistible__bu ---------------------------------------TDWDPGAALTS MMAR_2257|M.marinum_M YRNVAREHVAQVIATTHRYRREYGLRVTSGRKVVELRPDIDWDKGAALAW Mvan_4107|M.vanbaalenii_PYR-1 YREVAPEQVSEIVSATHQLGARRGLRVTSGRMLVELRPDLDWDKGTTLAW Mb2029|M.bovis_AF2122/97 YRNVADDSVDNLIAAVRRLGHAAGLRVTTGRKVVELRPDIAWDKGKALDW Rv2006|M.tuberculosis_H37Rv YRNVADDSVDNLIAAVRRLGHAAGLRVTTGRKVVELRPDIAWDKGKALDW MSMEG_3954|M.smegmatis_MC2_155 -------------------------------------------------- Mflv_4989|M.gilvum_PYR-GCK YRNVAAESVDEVVTAVRNIAQCNGLRADGGRRVVELKPDTGWHKGRAVEW MLBr_00392|M.leprae_Br4923 -------------------------------------------------- MUL_0906|M.ulcerans_Agy99 -------------------------------------------------- MAV_4352|M.avium_104 -------------------------------------------------- TH_1155|M.thermoresistible__bu IRARMGR----PEPVLPIYVGSELADEAAFDVLRLDGVSVVVH-HLGAAD MMAR_2257|M.marinum_M IRSLIFE----DSRVLPMYVGDDLTDEDAFDALRFSGVGIVVR-HDEDGD Mvan_4107|M.vanbaalenii_PYR-1 IRDRIDP----SGSLLPIYIGDDLTDEDAFDAVRFDGIGIVVG-HDEDGD Mb2029|M.bovis_AF2122/97 IGERLGPAEVGPDLRLPIYIGDDLTDEDAFDAVRFTGVGIVVR-HNEHGD Rv2006|M.tuberculosis_H37Rv IGERLGPAEVGPDLRLPIYIGDDLTDEDAFDAVRFTGVGIVVR-HNEHGD MSMEG_3954|M.smegmatis_MC2_155 ---------------LPVFIG-NPADDSAFRTVRRDGIGIVVVTHAEDEK Mflv_4989|M.gilvum_PYR-GCK ILDRIDG----DELLLPVYIGDDLTDEDGFDAVRLRGIGVAVR-SAESGD MLBr_00392|M.leprae_Br4923 -------------------------------------------------- MUL_0906|M.ulcerans_Agy99 -------------------------------------------------- MAV_4352|M.avium_104 -------------------------------------------------- TH_1155|M.thermoresistible__bu RPTGAQFRLDGAEEVCEFLRRGGNWIAYQRQTSNEAWTFSYRGYDPRQEK MMAR_2257|M.marinum_M RPTAANFTLRNPNEVRDFVRRGAGWLAHAHETQSRGWTFTFEGYDPPNEK Mvan_4107|M.vanbaalenii_PYR-1 RKTAANFTLQSPEQVREFIQRGSRWLAYKHQVSGEAWDYVFDGYDPQNEK Mb2029|M.bovis_AF2122/97 RRSAATFRLECPYTVCQFLSQLACDLQEAVQHDDP-WTLVFHGYDPGQER Rv2006|M.tuberculosis_H37Rv RRSAATFRLECPYTVCQFLSQLACDLQEAVQHDDP-WTLVFHGYDPGQER MSMEG_3954|M.smegmatis_MC2_155 RSTTATFRLDSPGAAATFRHRLAQEADRPTSIDPG-WVLTFDGYDPANER Mflv_4989|M.gilvum_PYR-GCK RRSAARFALDSPAAVCAFLARLSDQLAVEQDLTNDPWTLTFGGYLPEDER MLBr_00392|M.leprae_Br4923 -------------------------MITEEAFPVEPWQIRETRLDLNLLA MUL_0906|M.ulcerans_Agy99 -------------------------------------------------- MAV_4352|M.avium_104 -------------------------MIADESFPVDPWHVRETQLNLNLLA TH_1155|M.thermoresistible__bu LREALCTVGNGYFATRGAAPEARAG--QVHYPGTYAAGVFNRLDDVVDGR MMAR_2257|M.marinum_M LREALCTVGNGYFATRGAAPESKAG--QVHYPGTYAGGVFNRLDDLIGGT Mvan_4107|M.vanbaalenii_PYR-1 LREALCTVGNGYFATRGAAPESKAG--QVHYPGTYAAGVYNRLVDNVSGT Mb2029|M.bovis_AF2122/97 LREALCAVGNGYLGSRGCAPESAES--EAHYPGTYVAGVYNQLTDHIEGC Rv2006|M.tuberculosis_H37Rv LREALCAVGNGYLGSRGCAPESAES--EAHYPGTYVAGVYNQLTDHIEGC MSMEG_3954|M.smegmatis_MC2_155 FREALCTLGNGYFATRGCAPEAPAG--RFHYPGTYVAGIYNRLTDEIAGH Mflv_4989|M.gilvum_PYR-GCK LREALCTLGNGYLATRGAAPECDAS--RLHYPATYVAGIYNRLFDEIAGT MLBr_00392|M.leprae_Br4923 QSESLFALSNGHIGLRGNLDEGEPYGLPGTYLNSFYEIRPLPYAEAGYGY MUL_0906|M.ulcerans_Agy99 -------------------------------------------------- MAV_4352|M.avium_104 QSESLFTLSNGHIGLRGNLDEGEPYGLPGTYLNSFYEIRPLPYAEAGYGY TH_1155|M.thermoresistible__bu VTAHESMVNLPNWLPLTFRIEGGPWFDVDAVTLLDYRQTLDLRGAVLTRE MMAR_2257|M.marinum_M RTAHESLVNLPNWLPLTFRIDGGDWFDVDAVTLLSYRQTLDLRGAVLTRE Mvan_4107|M.vanbaalenii_PYR-1 EIDNESLVNLPNWLALTFRVDHGDWFDIDAVTVLSYRQTLDLRGAVLTRQ Mb2029|M.bovis_AF2122/97 TVDNESLVNLPNWLSLTFRIDGGAWFNVDTVELLSYRQTFDLRRATLTRS Rv2006|M.tuberculosis_H37Rv TVDNESLVNLPNWLSLTFRIDGGAWFNVDTVELLSYRQTFDLRRATLTRS MSMEG_3954|M.smegmatis_MC2_155 RTDNESLVNLPNWLALTFRFDDGPWLDVDDTDLQSYQQTLDLRRGVLTRQ Mflv_4989|M.gilvum_PYR-GCK TVDNESLVNLPNWLPVTFRVDGGAWFDIDAVEFTSYVTTLDLRRATLTRE MLBr_00392|M.leprae_Br4923 PEAGQTVVDVTNGKILRLFVED-EPFDVRYGEVIFHERVLDLCAGTLTRR MUL_0906|M.ulcerans_Agy99 -------------------------------------------------- MAV_4352|M.avium_104 PEAGQTLVDVTNGKIIRLLVED-EPFDVRYGELLSHERTLDLRGGTLTRS TH_1155|M.thermoresistible__bu LRFRDNAGRTTSVTQQRFVAMHTAHIAALETTLVAEDWSGTVDVRSTLDG MMAR_2257|M.marinum_M LTFRDDAGRTSSVTQHRFVSMNQAHVAALQTTIVGHDWSGTIEIRSTIDG Mvan_4107|M.vanbaalenii_PYR-1 VRFRDHAGRTSSLTQRRFVAMHLPHAGALETTVVAEDWSGTIEFRSTVDG Mb2029|M.bovis_AF2122/97 LRFRDAGGRVTTMTQERFASMNRPNLVALQTRIESENWSGTVDFRSLVDG Rv2006|M.tuberculosis_H37Rv LRFRDAGGRVTTMTQERFASMNRPNLVALQTRIESENWSGTVDFRSLVDG MSMEG_3954|M.smegmatis_MC2_155 FRFCDKAGRVATVTQHRLVAMHLPHLAMLQTMVTAENFSGTVEFRSEIDG Mflv_4989|M.gilvum_PYR-GCK FVMRDQAGRITRIRQRRLVAMHRPHVAAMATTVRAENWSGRLQLRSVLDG MLBr_00392|M.leprae_Br4923 ANWRSPADKQVKVVSTRLVSLAHRSVAAIEYVVEALDKFVRVTVQSELVS MUL_0906|M.ulcerans_Agy99 --------------------------------MEAVDDFARITVQSELVT MAV_4352|M.avium_104 AYWRSPAGKEVKVVSTRLVSLAQRGVAAIEYVVQAVGDFVRVTVQSELVT : . . : .:* : TH_1155|M.thermoresistible__bu DVRNGLVERYRDLRGDHLESLGKSALTGD--SVLLSVRTNQSRIPIAMAA MMAR_2257|M.marinum_M NVRNSGVERYRNLASNHLQGLQKAVLSEN--SVSMAVETTQSKIPVAVAA Mvan_4107|M.vanbaalenii_PYR-1 NVTNSLVERYRDLANEHLDSADTQELSNN--SVLLTMQTNQSRIPIAMAA Mb2029|M.bovis_AF2122/97 GVHNTLVDRYRQLSSQHLT-TAEIEVLAD--SVLLRTQTSQSGIAIAVAA Rv2006|M.tuberculosis_H37Rv GVHNTLVDRYRQLSSQHLT-TAEIEVLAD--SVLLRTQTSQSGIAIAVAA MSMEG_3954|M.smegmatis_MC2_155 AVTNSLVERYRDLSNVHLVGHEKRSLTAD--SLLLTAHTCQSHIRVAVAL Mflv_4989|M.gilvum_PYR-GCK GVENLGVERYRALSSRHLTVDAMRELSRD--AVLLQTHTGESQIQIAVAA MLBr_00392|M.leprae_Br4923 NEDQPETSGDPRVSAILDNPLEAVEHEATERGGLLMHRTRASSLMMAAGM MUL_0906|M.ulcerans_Agy99 NEDQPETSDDPRVSAILEHPLQAVDHENTECGALLMHRTRSSALMMAAAM MAV_4352|M.avium_104 NEDQPQTSGDPRVSAILENPLEEVDHENTDTGALLIHRTRSSALMMAAGM : .. : . : .* * : :* . TH_1155|M.thermoresistible__bu RTTAWRDGDPVSAGYRLVDEESEIGHQITTGLSRGQRLTVEKVVALSTG- MMAR_2257|M.marinum_M RTSLWRADEPVAATYRLLDEEFEIGHEIFTEAKLGQPLTVEKIVTLVSG- Mvan_4107|M.vanbaalenii_PYR-1 RNTVWRDGEPVPAAFALFDQGAEIGHDIAVHLSAGDAVTLEKVVTVYTG- Mb2029|M.bovis_AF2122/97 RSTLWRDGQRVDAQYRVARDTNRGGHDIQVTLSAGQSVTLEKVATIFTS- Rv2006|M.tuberculosis_H37Rv RSTLWRDGQRVDAQYRVARDTNRGGHDIQVTLSAGQSVTLEKVATIFTS- MSMEG_3954|M.smegmatis_MC2_155 RNTVWRGDSPARADYTLVDDRRRAGHVISCYIEAGQPVTLEKAVSVATS- Mflv_4989|M.gilvum_PYR-GCK RHRVT-GGEPESVDQRVFRDDCRIGHDIEVVVTAGQAVTLEKVIAVYTG- MLBr_00392|M.leprae_Br4923 DHEVEVPGRVEITTDARPDLAR---TTVICGLRPGQKLRIVKYLAYGWSS MUL_0906|M.ulcerans_Agy99 DHEVEVPGRVEITTDARPDLAR---TTVICGLRPGQKLRIVKYLAYGWSS MAV_4352|M.avium_104 DHEVEVPGRVEVSTDSRADLAR---TTVICGLRAGQKLRIVKYLAYGWSS . : *: : : * : . TH_1155|M.thermoresistible__bu -RDVGSSEPSESAERILERQGRFGEIRAAHTVAWAHLWRRLSIEFEDHTD MMAR_2257|M.marinum_M -LDVATSHPAIGAERRLGRQGRFAEICDAHRIAWSHLWERLSIEFSNHTE Mvan_4107|M.vanbaalenii_PYR-1 -RDVAISEPGVNAQRWVTRLGRFDELLDGHRTAWTHLWERLSIDFDDFTD Mb2029|M.bovis_AF2122/97 -RDAATLTAAISAQRCLGEAGRYAELCQQHVRAWARLWERCAIDLTGNTE Rv2006|M.tuberculosis_H37Rv -RDAATLTAAISAQRCLGEAGRYAELCQQHVRAWARLWERCAIDLTGNTE MSMEG_3954|M.smegmatis_MC2_155 -RDHATCEAANEATRRLQWVDRYHDVQQAHTTAWGQLWERFDVDIGGRTD Mflv_4989|M.gilvum_PYR-GCK -RDHGMSGPVTAAEREIAGADTFDRLEDGHRLAWAHLWERFNIDMGHDPN MLBr_00392|M.leprae_Br4923 LRSRPALHDQATAALHTARYSGWQGLLDAQRAYLNEFWDSADVEVEGDPE MUL_0906|M.ulcerans_Agy99 LRSRPALRDQVAGALHGARYSGWQGLIDTQRSYLDEFWDSADVEVEGDPE MAV_4352|M.avium_104 MRSRPALRDQVAAALHSARYTGWPGLLESQRKYLDNFWDCADVEVEGDPE . . : : : .:* ::. .: TH_1155|M.thermoresistible__bu ELRVMRLHLLHLLQTVSPHSADLDIGPPARGLHGEAYRGHIFWD-ELFIF MMAR_2257|M.marinum_M ELRVLRLHLLHLLQTVSYNSADLDVGVPARGLHGEAYRGHIFWD-ELFIF Mvan_4107|M.vanbaalenii_PYR-1 ELRILRLHLLHLLQTVSLNTADLDAGVPARGLHGEAYRGHIFWD-ELFIF Mb2029|M.bovis_AF2122/97 ELRLVRLHLLHLLQTISPHTAELDAGVPARGLNGEAYRGHVFWD-ALFVA Rv2006|M.tuberculosis_H37Rv ELRLVRLHLLHLLQTISPHTAELDAGVPARGLNGEAYRGHVFWD-ALFVA MSMEG_3954|M.smegmatis_MC2_155 ELRTVRLHLLHTLQTLSPHVRDLDIGVPARGLTGEAYRGHIFWD-ELFVA Mflv_4989|M.gilvum_PYR-GCK LLRLVRLHQLHLLQTLSPHTADLDVGVPARGLHGEAYRGHVFWD-ELFVF MLBr_00392|M.leprae_Br4923 SQQAVRFGLFHLLQAS---ARAERRAIPSKGLTGTGYDGHAFWDTEGFVL MUL_0906|M.ulcerans_Agy99 CQQAVRFGLFHLLQAS---ARAERRAIPSKGLTGTGYDGHAFWDSEGFVL MAV_4352|M.avium_104 SQQAVRFGLFHLLQAS---ARAERRAIAAKGLTGTGYDGHAFWDTEGYVL : :*: :* **: . .::** * .* ** *** :: TH_1155|M.thermoresistible__bu PVLNLRFPMITRSLLQYRYRRLPEARRAARLAGYRGAIFPWQSGSDGREE MMAR_2257|M.marinum_M PVLNLRLPAVTRSLLLYRYRRLLEAQRAAKLAGYRGAMYPWQSGSDGREE Mvan_4107|M.vanbaalenii_PYR-1 PVLNLRAPMITRSLLGYRYRRLPEARHAARAAGHSGAMFPWQSGSDGREE Mb2029|M.bovis_AF2122/97 PVLSLRMPKVARSLLDYRYRRLPAARRAAHRAGHLGAMYPWQSGSDGSEV Rv2006|M.tuberculosis_H37Rv PVLSLRMPKVARSLLDYRYRRLPAARRAAHRAGHLGAMYPWQSGSDGSEV MSMEG_3954|M.smegmatis_MC2_155 PVVSLRRPALTRALLAYRHRRLPEARRAARDAGFTGAMFPWQSGSNGREE Mflv_4989|M.gilvum_PYR-GCK PVLNMRLPKVTRSLLLYRYRRLPEARRAAAEAGYAGAMFPWQSGSDGREE MLBr_00392|M.leprae_Br4923 PVLTYTAPHAVADALRWRASTLQLAKDRAAELGLDGASFCWR-------- MUL_0906|M.ulcerans_Agy99 PVLTYTAPHAVADALRWRASTLDLAKERAAELGLDGASFPWR-------- MAV_4352|M.avium_104 PVLTYTAPHTVADALRWRASTLDLAKERAAELGLEGAAFPWR-------- **:. * . * :* * *: * * ** : *: TH_1155|M.thermoresistible__bu SPELHLNPRSGRWNSDPSHRAHHIGIAIAYNVWQFYQVTGDLAYLIDHGA MMAR_2257|M.marinum_M SPEQHLNPRSGRWIPDASHRAHHIGIAVAYNVWQFYQVTGDLAFMIDYGT Mvan_4107|M.vanbaalenii_PYR-1 SQRLHLNPRSGRWNPDASARAHHIGIAVAYSAWKFYQVTGDLAYLIDYGA Mb2029|M.bovis_AF2122/97 SQQLHLNPRSGRWTPDPSDRAHHVGLAVAYNAWHYYQVTGDRQYLVDCGA Rv2006|M.tuberculosis_H37Rv SQQLHLNPRSGRWTPDPSDRAHHVGLAVAYNAWHYYQVTGDRQYLVDCGA MSMEG_3954|M.smegmatis_MC2_155 SPALHLNPRSGRWNPDPSALAHHVGLAVAYNIWQYYQVTDDLEYLIDYGA Mflv_4989|M.gilvum_PYR-GCK SQRLHLNPRSGRWNPDASARAHHVGLAIAFNIWQHYQVTGDIGFLIDYGA MLBr_00392|M.leprae_Br4923 --TIRGQECSAYWP--AGTAAWHINADIAMAFERYRIVTGDHSLEEECGL MUL_0906|M.ulcerans_Agy99 --TIRGEECSAYWP--AGTAAWQINADIAMAFERYRTVTCDHSLEKDCGL MAV_4352|M.avium_104 --TIRGQECSAYWP--AGTAAWHINADIAMAFERYRIVTGDDDLEAECGL : : *. * .. * ::. :* :. ** * : * TH_1155|M.thermoresistible__bu ELLVEIARFWVSRAEFDTRRGRYRIRGVIGPDEFHAGYPDRPFDGVDDNA MMAR_2257|M.marinum_M EMMAEIARFWVSRATYDAERDRYHIKGVIGPDEFHSGYPDRPYDGVDDNA Mvan_4107|M.vanbaalenii_PYR-1 ELIAEVARFFVSLASYDEDRERFGIKGVIGPDEFHSGYPEAPYDGIDNNA Mb2029|M.bovis_AF2122/97 ELLVEIARFWVGLAKLDDSRGRYLIRGVIGPDEFHSGYPGNEYDGIDNNA Rv2006|M.tuberculosis_H37Rv ELLVEIARFWVGLAKLDDSRGRYLIRGVIGPDEFHSGYPGNEYDGIDNNA MSMEG_3954|M.smegmatis_MC2_155 ETLLEIARFWAGLALFSRERGRYVIPGVIGPDEFHTGYPGRLYDGIDNNA Mflv_4989|M.gilvum_PYR-GCK EMLVEITKFWVSAANLDPHRDRYVIRGVIGPDEFHSGYPGREYDGVDNNA MLBr_00392|M.leprae_Br4923 AVLIETARLWLSLGHHDR-HGVWHLDGVTGPDEYTA--------VVRDNV MUL_0906|M.ulcerans_Agy99 AVLIETARLWISLGHHDR-HGIWHLDGVTGPDEYTA--------IVRDNV MAV_4352|M.avium_104 PVLVETARLWLSLGHHDR-HGVWHLDGVTGPDEYTA--------VVRDNV : * :::: . . . : : : ** ****: : : :*. TH_1155|M.thermoresistible__bu YTNVMAVWVILRALEALNLIPLPNRIDVREKLNLTAAELAQWDDVSRRMY MMAR_2257|M.marinum_M YTNVMAAWVILRAIDALLLMPLPNRLDLYEKLALTEEELAQWDHVSRRMF Mvan_4107|M.vanbaalenii_PYR-1 YTNVMAVWVIMRAIDALNLLPLPNRLDLLEALGLHNEELAHWDDVSRRMY Mb2029|M.bovis_AF2122/97 YTNVMAVWVILRAMEALDLLPLTDRRHLIEKLGLTTQERDQWDDVSRRMF Rv2006|M.tuberculosis_H37Rv YTNVMAVWVILRAMEALDLLPLTDRRHLIEKLGLTTQERDQWDDVSRRMF MSMEG_3954|M.smegmatis_MC2_155 YTNVMAVWVILRALDALDAMPLADRTALLERLGLHGDELDKWEDVSHRMF Mflv_4989|M.gilvum_PYR-GCK YTNLMAVWVIVRTLEALERLPLSYRLALLETVGVGDEDLAHWEDVSRRMF MLBr_00392|M.leprae_Br4923 FTNLMAASNLITAADACLRQPE-----AAKAMGVTTEEMAAWRDAADAAN MUL_0906|M.ulcerans_Agy99 FTNLMAAHNLITAADACLRHPE-----AAQDMGVTTEGMAAWRDAADAVN MAV_4352|M.avium_104 FTNLMAAHNLRVAAEACNRHPD-----GAKALGVTTEETAAWRDAADAVK :**:**. : : :* * : : : * ..: TH_1155|M.thermoresistible__bu VPFHD--GIISQFEGYGELAELDWDGYRRRYGNIQRLDRILEAEGDDVNR MMAR_2257|M.marinum_M VPFHD--GVISQFDGYEQLAELDWDAYRQRYGNIQRLDRILEAEDDDVNR Mvan_4107|M.vanbaalenii_PYR-1 VPFHD--GVISQFEGYGDLADLDWDRLRRQYGNIQRLDRILEAENDDVNR Mb2029|M.bovis_AF2122/97 VPFHD--GVISQFEGYSELAELDWDHYRHRYGNIQRLDRILEAEGDSVNN Rv2006|M.tuberculosis_H37Rv VPFHD--GVISQFEGYSELAELDWDHYRHRYGNIQRLDRILEAEGDSVNN MSMEG_3954|M.smegmatis_MC2_155 VPFHN--GVISQFEGYESLVELDWDRYRHEYGNIQRLDRILEAENDNVNR Mflv_4989|M.gilvum_PYR-GCK VPFHD--GVITQFEGYDRLRELDWEAYRNRYDDLQRLDRILEAEGDSVNN MLBr_00392|M.leprae_Br4923 IPYDDELGVHQQCEGFTTFAEWDFEAN-------TTYPLFLHEAYVRLYP MUL_0906|M.ulcerans_Agy99 IPYDEELGVHQQCEGFTTLAEWDFETN-------TTYPLLLHEAYVRLYP MAV_4352|M.avium_104 IPYDSGLGVHQQCEGFTTFAEWDFEHN-------TTYPLLLHEAYVRLYP :*:.. *: * :*: : : *:: :*. : TH_1155|M.thermoresistible__bu YKASKQADALMLLYLLSADELRELLGHLGYRFTAEQIPGMVDYYLARTSH MMAR_2257|M.marinum_M YRASKQADALMLLYLLSADELGELLDRLGYHMERDQIPEMVDYYMARTSH Mvan_4107|M.vanbaalenii_PYR-1 YKASKQADALMLLYLLSADELREILDRLGYRFLPEQVPKMVDYYLARTSH Mb2029|M.bovis_AF2122/97 YQASKQADALMLLYLLSSDELIGLLARLGYRFAPTQIPGTVDYYLARTSD Rv2006|M.tuberculosis_H37Rv YQASKQADALMLLYLLSSDELIGLLARLGYRFAPTQIPGTVDYYLARTSD MSMEG_3954|M.smegmatis_MC2_155 YKASKQADVLMLFYLLSADEIRELLARLGYRFTPKQIPETVDYYLSRTSH Mflv_4989|M.gilvum_PYR-GCK YRAGKQADTLMLFYLLSADELYELFDRLGYNFAPEQIPATIDYYQKRTSH MLBr_00392|M.leprae_Br4923 AQVIKQADLVLAMQWQS------------HAFTPEQKARNVDYYERRMVR MUL_0906|M.ulcerans_Agy99 TQVIKQAHLVLAMQWQS------------HAFTAEQKARNVDYYERRMVR MAV_4352|M.avium_104 AQVIKQADLVLAMHWQS------------HAFTPEQKARNVDYYEPRMVR :. ***. :: : * : : * . :*** * TH_1155|M.thermoresistible__bu GSTLSAVVHAWVLARA-NRDRAMEYFERVLKSDVADIQGGTTAEGIHLAA MMAR_2257|M.marinum_M GSTLSAAVHGWVLARA-NRDRALEFFQQVLESDVADIQGGTTAEGVHLAA Mvan_4107|M.vanbaalenii_PYR-1 GSTLSGVVHTWVLARA-NRNRALEFFQQALKSDVSDIQGGTTSEGIHLAA Mb2029|M.bovis_AF2122/97 GSTLSAVVHAWVLARA-NRSNAMEYFRQVLRSDIADVQGGTTQEGIHLAA Rv2006|M.tuberculosis_H37Rv GSTLSAVVHAWVLARA-NRSNAMEYFRQVLRSDIADVQGGTTQEGIHLAA MSMEG_3954|M.smegmatis_MC2_155 GSTLSAVVHSWVLARG-HREQAMEFFVQALNSDVADIQGGTTAEGIHLAA Mflv_4989|M.gilvum_PYR-GCK GSTLSAVVHSWVLARG-DRREAMHYFRRVLASDVVDIQRGTTAEGIHLAA MLBr_00392|M.leprae_Br4923 DSSLSACTQAVMCAEVGHLELAHDYAYEAALIDLRDLHR-NTRDGLHMAS MUL_0906|M.ulcerans_Agy99 DSSLSACTQAVMCADVGHLELAHDYAYEAALIDLRDLHR-NTRDGLHMAS MAV_4352|M.avium_104 DSSLSACTQAVMCAEVGHLELAHDYAYEAALIDLRDLHH-NTRDGLHMAS .*:**. .: : * . * .: .. *: *:: .* :*:*:*: TH_1155|M.thermoresistible__bu MAGSVDLVQRCFTGLETRSDRIVLSPNWPESLGALGFPIRYRGHQMYVRV MMAR_2257|M.marinum_M MAGSVDFVQRCFTGLEIRADRIVLSPHWPEYLGALGFPIHYRGNHLHLRV Mvan_4107|M.vanbaalenii_PYR-1 MAGTVDLMQRCFTGLETRSNRIILSPYWPESLGVLAIPIHYRGLHLHLRV Mb2029|M.bovis_AF2122/97 MAGSIDLPQRCYSGLELRDDRLVLSPQWPEALGPLEFPFVYRRHQLSLRI Rv2006|M.tuberculosis_H37Rv MAGSIDLLQRCYSGLELRDDRLVLSPQWPEALGPLEFPFVYRRHQLSLRI MSMEG_3954|M.smegmatis_MC2_155 MAGSVDLLQRCFTGLETRGDRLVLGPCWPEALGVLSFRMYYRGHNLHLRV Mflv_4989|M.gilvum_PYR-GCK MAGSIDLLQRCFTGLELRRDRIVVGPMWPEPLGRLAFTFRYRGHRLRLTV MLBr_00392|M.leprae_Br4923 LAGAWTALVGGFGGLRDDEGILSIDPQLPHGISRLRFRLRWRGFRLTVDA MUL_0906|M.ulcerans_Agy99 LAGAWTALVGGFGGLRDDEGILSIDPQLPDGISRLRFRLRWRGYRLTVDA MAV_4352|M.avium_104 LAGAWTALVSGFGGLRDDEGVLSLDPQLPDGISRLRFRLRWRDFRVTVDV :**: : **. . : :.* *. :. * : : :* .: : TH_1155|M.thermoresistible__bu SGRGAEISVAPRDLPPVAVECNGRVQRLEPGTTVRFT------------- MMAR_2257|M.marinum_M SGKGAEISVEPRDVPPVEVECHGRVERLLPGSTVRFS------------- Mvan_4107|M.vanbaalenii_PYR-1 SGKGVIISVDPRDAAGIEVECRGQVVQLMPGTTVRFPG------------ Mb2029|M.bovis_AF2122/97 SGRSATLTAESGDAEPIEVECRGHVQRLRCGHTIEVGCSR---------- Rv2006|M.tuberculosis_H37Rv SGRSATLTAESGDAEPIEVECRGHVQRLRCGHTIEVGCSR---------- MSMEG_3954|M.smegmatis_MC2_155 SGRTASVISAIGSAAPITLECRGRTWQLCAGTTIDVG------------- Mflv_4989|M.gilvum_PYR-GCK LGRSSTLSAEPSEASPILVECRGQAQTLVAGGTVEFTR------------ MLBr_00392|M.leprae_Br4923 RHADVTYTLRDGPGGELTIRHAGEHLTLKSDSPSTIAVRDRKPLLPPPSQ MUL_0906|M.ulcerans_Agy99 NHSTVTFTLRDGPGAELTIRHAGKDLELSSTKPTTISVHKHKPLLPPPPQ MAV_4352|M.avium_104 NHADVTYTLRDGPGGELTIQHAGAELELSTQSPTTVAVRPRKPLLPPPQQ : :. * * . . TH_1155|M.thermoresistible__bu ---------------------- MMAR_2257|M.marinum_M ---------------------- Mvan_4107|M.vanbaalenii_PYR-1 ---------------------- Mb2029|M.bovis_AF2122/97 ---------------------- Rv2006|M.tuberculosis_H37Rv ---------------------- MSMEG_3954|M.smegmatis_MC2_155 ---------------------- Mflv_4989|M.gilvum_PYR-GCK ---------------------- MLBr_00392|M.leprae_Br4923 PPGREPVSRRHKSLIISAAR-- MUL_0906|M.ulcerans_Agy99 PPGREPVHRRNMAAKVWASTAT MAV_4352|M.avium_104 PPGREPTHRRAVSRSSPGQ---