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VRKLGPVTIDPRRHDAVLFDTTLDATQELVRQLQEVGVGTGVFGSGLDVPIVAAGRLAVRPGRCVVVSAH SAGVTAARESGFALIIGVDRTGCRDALRRDGADTVVTDLSEVSVRTGDRRMSQLPDALQALGLADGLVAR QPAVFFDFDGTLSDIVEDPDAAWLAPGALEALQKLAARCPIAVLSGRDLADVTQRVGLPGIWYAGSHGFE LTAPDGTHHQNDAAAAAIPVLKQAAAELRQQLGPFPGVVVEHKRFGVAVHYRNAARDRVGEVAAAVRTAE QRHALRVTTGREVIELRPDVDWDKGKTLLWVLDHLPHSGSAPLVPIYLGDDITDEDAFDVVGPHGVPIVV RHTDDGDRATAALFALDSPARVAEFTDRLARQLREAPLRAT
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv3372 | otsB2 | - | 100% (391) | POSSIBLE TREHALOSE 6-PHOSPHATE PHOSPHATASE OTSB2 (TREHALOSE-PHOSPHATASE) (TPP) |
| M. tuberculosis H37Rv | Rv2006 | otsB1 | 3e-99 | 56.64% (339) | trehalose-6-phosphate phosphatase OtsB1 |
| M. tuberculosis H37Rv | Rv3400 | - | 8e-07 | 46.88% (64) | hydrolase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3407 | otsB2 | 0.0 | 100.00% (391) | trehalose 6-phosphate phosphatase |
| M. gilvum PYR-GCK | Mflv_4989 | - | 1e-103 | 52.06% (388) | HAD family hydrolase |
| M. leprae Br4923 | MLBr_00414 | otsB2 | 1e-154 | 67.06% (425) | putative trehalose-6-phosphate phosphatase |
| M. abscessus ATCC 19977 | MAB_0578c | - | 1e-19 | 34.23% (222) | putative trehalose phosphatase |
| M. marinum M | MMAR_1156 | otsB2 | 1e-163 | 75.00% (384) | trehalose-6-phosphate phosphatase OtsB2 |
| M. avium 104 | MAV_4338 | - | 1e-149 | 72.14% (384) | glycosyl hydrolase |
| M. smegmatis MC2 155 | MSMEG_6043 | otsB | 4e-19 | 33.74% (243) | trehalose-phosphatase |
| M. thermoresistible (build 8) | TH_1155 | - | 2e-23 | 53.00% (100) | trehalose 6-phosphate phosphorylase |
| M. ulcerans Agy99 | MUL_0921 | otsB2 | 1e-162 | 73.70% (384) | trehalose-6-phosphate phosphatase OtsB2 |
| M. vanbaalenii PYR-1 | Mvan_4107 | - | 1e-110 | 51.18% (422) | HAD family hydrolase |
CLUSTAL 2.0.9 multiple sequence alignment
TH_1155|M.thermoresistible__bu --------------------------------------------------
Mvan_4107|M.vanbaalenii_PYR-1 MKLPVTIDPRYHDAVLLDLDGALTSEAPLFGPTVDLARKLQSIGVAAAAY
Mflv_4989|M.gilvum_PYR-GCK --MPVFIDPRHHDAVIFEVDDPVADEVALSASQGDLARRLTAAGIGVG--
Rv3372|M.tuberculosis_H37Rv --------------------------------------------------
Mb3407|M.bovis_AF2122/97 --------------------------------------------------
MLBr_00414|M.leprae_Br4923 --------------------------------------------------
MMAR_1156|M.marinum_M --------------------------------------------------
MUL_0921|M.ulcerans_Agy99 --------------------------------------------------
MAV_4338|M.avium_104 --------------------------------------------------
MAB_0578c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_6043|M.smegmatis_MC2_155 --------------------------------------------------
TH_1155|M.thermoresistible__bu --------------------------------------------------
Mvan_4107|M.vanbaalenii_PYR-1 SSNGQCRQALKAAGIDDLFGVCIDGMEGDRGTAEKPDPAVLLEAARRIGA
Mflv_4989|M.gilvum_PYR-GCK ----------------------------------CAESAMLRETARRLGV
Rv3372|M.tuberculosis_H37Rv --------------------------------------------------
Mb3407|M.bovis_AF2122/97 --------------------------------------------------
MLBr_00414|M.leprae_Br4923 --------------------------------------------------
MMAR_1156|M.marinum_M --------------------------------------------------
MUL_0921|M.ulcerans_Agy99 --------------------------------------------------
MAV_4338|M.avium_104 --------------------------------------------------
MAB_0578c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_6043|M.smegmatis_MC2_155 --------------------------------------------------
TH_1155|M.thermoresistible__bu --------------------------------------------------
Mvan_4107|M.vanbaalenii_PYR-1 RPQRCVVVENSAAGVAAGRAGGFALVVGIDGTEVADELTRHGADVVLAGL
Mflv_4989|M.gilvum_PYR-GCK HPGRCVVVAGGEAGVRTARAGGFALIVGIDRAERAEDLRSCGADVVVPDL
Rv3372|M.tuberculosis_H37Rv --------------------------------------------------
Mb3407|M.bovis_AF2122/97 --------------------------------------------------
MLBr_00414|M.leprae_Br4923 --------------------------------------------------
MMAR_1156|M.marinum_M --------------------------------------------------
MUL_0921|M.ulcerans_Agy99 --------------------------------------------------
MAV_4338|M.avium_104 --------------------------------------------------
MAB_0578c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_6043|M.smegmatis_MC2_155 --------------------------------------------------
TH_1155|M.thermoresistible__bu --------------LSNALASYGLLIGIVANRQPVVFCRFDGALA----D
Mvan_4107|M.vanbaalenii_PYR-1 ADIAVRTGDRRISELPNALASYGQLIGITSARESMLFLDYDGTLSPIVSD
Mflv_4989|M.gilvum_PYR-GCK VAVTVRDGYRRMSELADALQSYGEIVPLAETRTPVVLLDFDGTLSDIVGD
Rv3372|M.tuberculosis_H37Rv --------------------------------------------------
Mb3407|M.bovis_AF2122/97 --------------------------------------------------
MLBr_00414|M.leprae_Br4923 --------------------------------------------------
MMAR_1156|M.marinum_M --------------------------------------------------
MUL_0921|M.ulcerans_Agy99 --------------------------------------------------
MAV_4338|M.avium_104 --------------------------------------------------
MAB_0578c|M.abscessus_ATCC_199 ----------MVSAQDLPVELRRALSEVARTPRLLVASDYDGTIAPLVNN
MSMEG_6043|M.smegmatis_MC2_155 --------------MSLSGDLQRALTAVAATPHLLVTSDFDGTLAPIVNN
TH_1155|M.thermoresistible__bu RDTATLVDGAAAALRKLASL--CPVAVISGREVSELRARVGVDGLWYAGG
Mvan_4107|M.vanbaalenii_PYR-1 PAAARLVEGADEALELVSKV--CPVAILSGRDLADVSARVGTPGVWYAGS
Mflv_4989|M.gilvum_PYR-GCK PDTAALVPGARSVLDALAAR--CPVAVVSGRALADIRDRIGVPGIWYAGS
Rv3372|M.tuberculosis_H37Rv ----------------MRKL--GPVTIDPRRH------------------
Mb3407|M.bovis_AF2122/97 ----------------MRKL--GPVTIDPRRH------------------
MLBr_00414|M.leprae_Br4923 ----------------------MPVTIDPRRHSAALFD------------
MMAR_1156|M.marinum_M ----------------------MSVTIDPRRH------------------
MUL_0921|M.ulcerans_Agy99 ----------------------MSVTIDPRRH------------------
MAV_4338|M.avium_104 ----------------MGES--GPVVIDPRRH------------------
MAB_0578c|M.abscessus_ATCC_199 PDHARPHPESTTALRALAGLPSTTSALISGRALRDLATLSRLPSEVHLVG
MSMEG_6043|M.smegmatis_MC2_155 PADARPLADAAEALAALAELPQTASALISGRALEVLRALSGMPDTVHLVG
. .: . *
TH_1155|M.thermoresistible__bu HGREVVAPDGSHHRFDG---------------------------------
Mvan_4107|M.vanbaalenii_PYR-1 HGFELTSPDGAYHCNDAAAVFVPVLEEAAAELNKTLAQIAGVRVEHKRFA
Mflv_4989|M.gilvum_PYR-GCK HGFELCSPDGGIQENEAGLEIVRVLAGALAEVRERVGAVDGVLIEDKRFS
Rv3372|M.tuberculosis_H37Rv --------------------------------------------------
Mb3407|M.bovis_AF2122/97 --------------------------------------------------
MLBr_00414|M.leprae_Br4923 --------------------------------------------------
MMAR_1156|M.marinum_M --------------------------------------------------
MUL_0921|M.ulcerans_Agy99 --------------------------------------------------
MAV_4338|M.avium_104 --------------------------------------------------
MAB_0578c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_6043|M.smegmatis_MC2_155 --------------------------------------------------
TH_1155|M.thermoresistible__bu -------------------------------------------TDWDPGA
Mvan_4107|M.vanbaalenii_PYR-1 VAVHYREVAPEQVSEIVSATHQLGARRGLRVTSGRMLVELRPDLDWDKGT
Mflv_4989|M.gilvum_PYR-GCK IAVHYRNVAAESVDEVVTAVRNIAQCNGLRADGGRRVVELKPDTGWHKGR
Rv3372|M.tuberculosis_H37Rv --------------------------------------------------
Mb3407|M.bovis_AF2122/97 --------------------------------------------------
MLBr_00414|M.leprae_Br4923 --------------------------------------------------
MMAR_1156|M.marinum_M --------------------------------------------------
MUL_0921|M.ulcerans_Agy99 --------------------------------------------------
MAV_4338|M.avium_104 --------------------------------------------------
MAB_0578c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_6043|M.smegmatis_MC2_155 --------------------------------------------------
TH_1155|M.thermoresistible__bu ALTSIRARMGRPEPVLPIYVGSELADEAAFDVLRLDGVSVVVHHLGAADR
Mvan_4107|M.vanbaalenii_PYR-1 TLAWIRDRIDPSGSLLPIYIGDDLTDEDAFDAVRFDGIGIVVGHDEDGDR
Mflv_4989|M.gilvum_PYR-GCK AVEWILDRIDGDELLLPVYIGDDLTDEDGFDAVRLRGIGVAVRSAESGDR
Rv3372|M.tuberculosis_H37Rv -------------------------DAVLFDTT-----------------
Mb3407|M.bovis_AF2122/97 -------------------------DAVLFDTT-----------------
MLBr_00414|M.leprae_Br4923 ------------------------LDAVVTDTP-----------------
MMAR_1156|M.marinum_M -------------------------DAVLFDTA-----------------
MUL_0921|M.ulcerans_Agy99 -------------------------DAVLFDTA-----------------
MAV_4338|M.avium_104 -------------------------DAVLFGVG-----------------
MAB_0578c|M.abscessus_ATCC_199 ------------------------SHGSEFDAG-----------------
MSMEG_6043|M.smegmatis_MC2_155 ------------------------SHGAEFTSG-----------------
.
TH_1155|M.thermoresistible__bu PTGAQFRLDGAEEVCEFLRRGGNWIAYQRQTSNEAWTFSYRGYDPRQEKL
Mvan_4107|M.vanbaalenii_PYR-1 KTAANFTLQSPEQVREFIQRGSRWLAYKHQVSGEAWDYVFDGYDPQNEKL
Mflv_4989|M.gilvum_PYR-GCK RSAARFALDSPAAVCAFLARLSDQLAVEQDLTNDPWTLTFGGYLPEDERL
Rv3372|M.tuberculosis_H37Rv -------LDATQELVRQLQEVG----------------------------
Mb3407|M.bovis_AF2122/97 -------LDATQELVRQLQEVG----------------------------
MLBr_00414|M.leprae_Br4923 -------LDSTVTLVRQLQGIG----------------------------
MMAR_1156|M.marinum_M -------LNSTQALVRQLQQAR----------------------------
MUL_0921|M.ulcerans_Agy99 -------LNSTQALVRQLQQAR----------------------------
MAV_4338|M.avium_104 -------DALGSALASQLGQIG----------------------------
MAB_0578c|M.abscessus_ATCC_199 -----FVHAIDGDAKALLKTIATK--------------------------
MSMEG_6043|M.smegmatis_MC2_155 -----FGHDID---TALLQRITDR--------------------------
:
TH_1155|M.thermoresistible__bu REALCTVGNGYFATRGAAPEARAGQVHYPGTYAAGVFNRLDDVVDGRVTA
Mvan_4107|M.vanbaalenii_PYR-1 REALCTVGNGYFATRGAAPESKAGQVHYPGTYAAGVYNRLVDNVSGTEID
Mflv_4989|M.gilvum_PYR-GCK REALCTLGNGYLATRGAAPECDASRLHYPATYVAGIYNRLFDEIAGTTVD
Rv3372|M.tuberculosis_H37Rv ------VGTGVFGS-----------GLD----------------------
Mb3407|M.bovis_AF2122/97 ------VGTGVFGS-----------GLD----------------------
MLBr_00414|M.leprae_Br4923 ------VGTAVFSTNRNSQGVLTATGLDHLFPVH----------------
MMAR_1156|M.marinum_M ------VGTATFASGGG--------GHD----------------------
MUL_0921|M.ulcerans_Agy99 ------VGTATFASGGG--------GHD----------------------
MAV_4338|M.avium_104 ------VGTAAIAAD---------D-------------------------
MAB_0578c|M.abscessus_ATCC_199 ---LSAIAAEYPGVAIELKPASVALHVRN---------------------
MSMEG_6043|M.smegmatis_MC2_155 ---LHTIASGRPGVTVETKPASVALHVRN---------------------
:. .
TH_1155|M.thermoresistible__bu HESMVNLPNWLPLTFRIEGGPWFDVDAVTLLDYRQTLDLRGAVLTRELRF
Mvan_4107|M.vanbaalenii_PYR-1 NESLVNLPNWLALTFRVDHGDWFDIDAVTVLSYRQTLDLRGAVLTRQVRF
Mflv_4989|M.gilvum_PYR-GCK NESLVNLPNWLPVTFRVDGGAWFDIDAVEFTSYVTTLDLRRATLTREFVM
Rv3372|M.tuberculosis_H37Rv -----------------------------------------VPIVAAGRL
Mb3407|M.bovis_AF2122/97 -----------------------------------------VPIVAAGRL
MLBr_00414|M.leprae_Br4923 -------------------------------VDGLASGKVTILVAAANRL
MMAR_1156|M.marinum_M -------------------------------------AAIQALTESADRV
MUL_0921|M.ulcerans_Agy99 -------------------------------------AAIQALIESADRV
MAV_4338|M.avium_104 ------------------------------------------PAAAADRL
MAB_0578c|M.abscessus_ATCC_199 ----------------------------------ASEEDADAALRQALSV
MSMEG_6043|M.smegmatis_MC2_155 ----------------------------------ASPEHGAAALTEARTA
TH_1155|M.thermoresistible__bu RDNAGRTTSVTQQRFVAMHTAHIAALETTLVAEDWSGTVDVRSTLDGDVR
Mvan_4107|M.vanbaalenii_PYR-1 RDHAGRTSSLTQRRFVAMHLPHAGALETTVVAEDWSGTIEFRSTVDGNVT
Mflv_4989|M.gilvum_PYR-GCK RDQAGRITRIRQRRLVAMHRPHVAAMATTVRAENWSGRLQLRSVLDGGVE
Rv3372|M.tuberculosis_H37Rv AVRPGRCVVVSAH-SAGVTAARESGFALIIG----VDRTGCRDALRRDGA
Mb3407|M.bovis_AF2122/97 AVRPGRCVVVSAH-SAGVTAARESGFALIIG----VDRTGCRDALRRDGA
MLBr_00414|M.leprae_Br4923 MAQPGRCVVVAVD-AAGITAARYGGFALVLGLVIGEDQTGHRDTLRNSGA
MMAR_1156|M.marinum_M GARPGRCVVITAD-AASVAAARDSGFALVIG----VDQAGHRDALPDHGA
MUL_0921|M.ulcerans_Agy99 GARPGRCVVITAD-AASVAAARDSGFALVIG----VDQAGHRDALPDHGA
MAV_4338|M.avium_104 RVRPGRCVVVAGD-PAAVEAARAAGFALVIG---LAPDGRDGDGLRAAGA
MAB_0578c|M.abscessus_ATCC_199 ANGWGAQVTEGKKVLEFAVIPTDKGQALDILRH-QEGATAAVFFGDDVTD
MSMEG_6043|M.smegmatis_MC2_155 AAEWDAQLTEGKAVLEFAVIQTDKGEAVDILRQ-QENATAVVFFGDDVTD
. . :
TH_1155|M.thermoresistible__bu NGLVERYRDLRGDHLESLGKSALTGDSVLLSVRTNQSRIPIAMAARTTAW
Mvan_4107|M.vanbaalenii_PYR-1 NSLVERYRDLANEHLDSADTQELSNNSVLLTMQTNQSRIPIAMAARNTVW
Mflv_4989|M.gilvum_PYR-GCK NLGVERYRALSSRHLTVDAMRELSRDAVLLQTHTGESQIQIAVAARHRVT
Rv3372|M.tuberculosis_H37Rv DTVVTDLSEVS----------VRTGD-------RRMSQLPDALQAL----
Mb3407|M.bovis_AF2122/97 DTVVTDLSEVS----------VRTGD-------RRMSQLPDALQAL----
MLBr_00414|M.leprae_Br4923 DTVVADLGEVI----------VRTGD-------RRMSELPDALQTL----
MMAR_1156|M.marinum_M DTVLADLDEVR----------VRAGD-------RHMSELPDALQAL----
MUL_0921|M.ulcerans_Agy99 DTVLADLDEVR----------VRAGD-------RHMSELPDALQAL----
MAV_4338|M.avium_104 DAVIAELEQIT----------VRTGD-------RRMSQLPDASQALT---
MAB_0578c|M.abscessus_ATCC_199 EKAFKRLHGPDVG------VKVGDGETLAGYRIPDTESVGTALAFLLEER
MSMEG_6043|M.smegmatis_MC2_155 EKAFRRLRGDDVG------VKVGPGESLAAYRVDSPEDVAAALDHLLAVR
: . : . : *
TH_1155|M.thermoresistible__bu RDGDPVSAGYRLVDEESEIGHQITTGLSRG--------QRLTVEKVVALS
Mvan_4107|M.vanbaalenii_PYR-1 RDGEPVPAAFALFDQGAEIGHDIAVHLSAG--------DAVTLEKVVTVY
Mflv_4989|M.gilvum_PYR-GCK G-GEPESVDQRVFRDDCRIGHDIEVVVTAG--------QAVTLEKVIAVY
Rv3372|M.tuberculosis_H37Rv -------------------------GLADG--------LVARQPAVFFDF
Mb3407|M.bovis_AF2122/97 -------------------------GLADG--------LVARQPAVFFDF
MLBr_00414|M.leprae_Br4923 -------------------------GLTDD--------LTARQPAVFFDF
MMAR_1156|M.marinum_M -------------------------GRPDG--------LTVPRPAVFFDF
MUL_0921|M.ulcerans_Agy99 -------------------------GRPDG--------LTVPRPAVFFDF
MAV_4338|M.avium_104 -------------------------GGADG--------LAGRHPAVFFDF
MAB_0578c|M.abscessus_ATCC_199 RTWLLGGHATPIERLTMLANSRTIALVTPTGDVTWMCHPEPDSAAVFAHL
MSMEG_6043|M.smegmatis_MC2_155 R----GA-------------------------------------------
TH_1155|M.thermoresistible__bu TGRDVGSSEPSESAERILERQGRFGEIRAAHTVAWAHLWRRLSIEFEDHT
Mvan_4107|M.vanbaalenii_PYR-1 TGRDVAISEPGVNAQRWVTRLGRFDELLDGHRTAWTHLWERLSIDFDDFT
Mflv_4989|M.gilvum_PYR-GCK TGRDHGMSGPVTAAEREIAGADTFDRLEDGHRLAWAHLWERFNIDMGHDP
Rv3372|M.tuberculosis_H37Rv DG------------------------------------------------
Mb3407|M.bovis_AF2122/97 DG------------------------------------------------
MLBr_00414|M.leprae_Br4923 DG------------------------------------------------
MMAR_1156|M.marinum_M DG------------------------------------------------
MUL_0921|M.ulcerans_Agy99 DG------------------------------------------------
MAV_4338|M.avium_104 DG------------------------------------------------
MAB_0578c|M.abscessus_ATCC_199 LGGPEAGHFTIGPARSALPLGQKYIDSTMTVETRWASLQVTDYLAHDEVP
MSMEG_6043|M.smegmatis_MC2_155 --------------------------------------------------
TH_1155|M.thermoresistible__bu DELRVMRLHLLHLLQTVSPHSADLDIGPPARGLHGEAYRGHIFWDELFIF
Mvan_4107|M.vanbaalenii_PYR-1 DELRILRLHLLHLLQTVSLNTADLDAGVPARGLHGEAYRGHIFWDELFIF
Mflv_4989|M.gilvum_PYR-GCK NLLRLVRLHQLHLLQTLSPHTADLDVGVPARGLHGEAYRGHVFWDELFVF
Rv3372|M.tuberculosis_H37Rv ---------------TLSDIVEDPDAAWLAPGALEALQK-----------
Mb3407|M.bovis_AF2122/97 ---------------TLSDIVEDPDAAWLAPGALEALQK-----------
MLBr_00414|M.leprae_Br4923 ---------------TLSDIVDDPDSARPVPGATEALQK-----------
MMAR_1156|M.marinum_M ---------------TLSEIVDDPDAATPTAGAVAALQQ-----------
MUL_0921|M.ulcerans_Agy99 ---------------TLSEIVDDPDAATPTAGAVAALQQ-----------
MAV_4338|M.avium_104 ---------------TLSDIVDDPDAARPVAGATAALTR-----------
MAB_0578c|M.abscessus_ATCC_199 GRTDLIRVVTG-EADAVVTFAPRPEFGQAPVQLVAEADGLRVLGTN----
MSMEG_6043|M.smegmatis_MC2_155 --------------------------------------------------
TH_1155|M.thermoresistible__bu PVLNLRFPMITRSLLQYRYRRLPEARRAAR------------LAGYRGAI
Mvan_4107|M.vanbaalenii_PYR-1 PVLNLRAPMITRSLLGYRYRRLPEARHAAR------------AAGHSGAM
Mflv_4989|M.gilvum_PYR-GCK PVLNMRLPKVTRSLLLYRYRRLPEARRAAA------------EAGYAGAM
Rv3372|M.tuberculosis_H37Rv --LAARCPIAVLS-----GRDLADVTQRVG------------LPG-----
Mb3407|M.bovis_AF2122/97 --LAARCPIAVLS-----GRDLADVTQRVG------------LPG-----
MLBr_00414|M.leprae_Br4923 --LATHCPVAILS-----GRDLADVIKRIG------------VPG-----
MMAR_1156|M.marinum_M --LAAQCPVAILS-----GRDLADVSQRVG------------LPG-----
MUL_0921|M.ulcerans_Agy99 --LAAQCPVAILS-----GRDLADVSQRVG------------LPG-----
MAV_4338|M.avium_104 --LAARCPVAVLS-----GRDLADVTKRVG------------VPG-----
MAB_0578c|M.abscessus_ATCC_199 DPIVLRAPGVTWTIGADDQTATATISPANGPIILELRCGTEDLGENPTSE
MSMEG_6043|M.smegmatis_MC2_155 --------------------------------------------------
TH_1155|M.thermoresistible__bu FPWQSGSDGREESPELHLNPRSGRWNSDPSHRAHHIGIAIAYNVWQFYQV
Mvan_4107|M.vanbaalenii_PYR-1 FPWQSGSDGREESQRLHLNPRSGRWNPDASARAHHIGIAVAYSAWKFYQV
Mflv_4989|M.gilvum_PYR-GCK FPWQSGSDGREESQRLHLNPRSGRWNPDASARAHHVGLAIAFNIWQHYQV
Rv3372|M.tuberculosis_H37Rv -IWYAGSHG------FELTAPDG---------THHQNDAAAAAIPVLKQA
Mb3407|M.bovis_AF2122/97 -IWYAGSHG------FELTAPDG---------THHQNDAAAAAIPVLKQA
MLBr_00414|M.leprae_Br4923 -IWYSGSHG------FESTAPDG---------THHQNDAAEATIPILEQA
MMAR_1156|M.marinum_M -IWYAGSHG------FELTAPDG---------THHQNEAAAAAIPVLEQA
MUL_0921|M.ulcerans_Agy99 -IWYAGSHG------FELTAPDG---------THHQNEAAAAAIPVLEQA
MAV_4338|M.avium_104 -IWYAGSHG------FELTAPDG---------SHHQNDDAAAAIPVLAQA
MAB_0578c|M.abscessus_ATCC_199 PELRERAESYWRDWAQTLTLPERKPGLMKRSALTLRGLVHAESGAILAAA
MSMEG_6043|M.smegmatis_MC2_155 --------------------------------------------------
TH_1155|M.thermoresistible__bu TGDLAYLIDHGAELLVEIARFWVSRAEFDTRRGRYRIRGVIGPDEFHAGY
Mvan_4107|M.vanbaalenii_PYR-1 TGDLAYLIDYGAELIAEVARFFVSLASYDEDRERFGIKGVIGPDEFHSGY
Mflv_4989|M.gilvum_PYR-GCK TGDIGFLIDYGAEMLVEITKFWVSAANLDPHRDRYVIRGVIGPDEFHSGY
Rv3372|M.tuberculosis_H37Rv AAELRQQLGPFPGVVVEHKRFGVAVHYRNAARDR----------------
Mb3407|M.bovis_AF2122/97 AAELRQQLGPFPGVVVEHKRFGVAVHYRNAARDR----------------
MLBr_00414|M.leprae_Br4923 ATQLRDQLGPIPGVMVEHKRFGVAVHYRNVARDR----------------
MMAR_1156|M.marinum_M AAQLRDRLGSIPGVMVEHKRFGVATHYRNAARDR----------------
MUL_0921|M.ulcerans_Agy99 AAQLRDRLGSIPGVMVEHKRFGVATHYRNAARNR----------------
MAV_4338|M.avium_104 AGRLSDELGTIPGVVVEHKRFGVAVHYRNAARDR----------------
MAB_0578c|M.abscessus_ATCC_199 TTSLPEDIGGIRNWDYRYCWLRDASMTASALVALGSLSEAEG--LLGWLH
MSMEG_6043|M.smegmatis_MC2_155 --------------------------------------------------
TH_1155|M.thermoresistible__bu PDRPFDGVDDNAYTNVMAVWVILRALEALNLIPLPNRIDVREKLNLTAAE
Mvan_4107|M.vanbaalenii_PYR-1 PEAPYDGIDNNAYTNVMAVWVIMRAIDALNLLPLPNRLDLLEALGLHNEE
Mflv_4989|M.gilvum_PYR-GCK PGREYDGVDNNAYTNLMAVWVIVRTLEALERLPLSYRLALLETVGVGDED
Rv3372|M.tuberculosis_H37Rv ---------------VGEVAAAVRTAEQRHALRVTTGREVIELR------
Mb3407|M.bovis_AF2122/97 ---------------VGEVAAAVRTAEQRHALRVTTGREVIELR------
MLBr_00414|M.leprae_Br4923 ---------------VNEVAVAVRTAGQRNALRVTTGREVIELR------
MMAR_1156|M.marinum_M ---------------VGEIAAVVRAAGQRDGLRVTTGREVIELR------
MUL_0921|M.ulcerans_Agy99 ---------------VGKIAAVVRAAGQRDGLRVTTGREVIELH------
MAV_4338|M.avium_104 ---------------VGEVAAAVRAAGRHDALRVTTGREVIELR------
MAB_0578c|M.abscessus_ATCC_199 RVLEHLPGPDRLHPLYTLAGTALPPEAVIDSLPGYAGSRPVRVGNAANSQ
MSMEG_6043|M.smegmatis_MC2_155 --------------------------------------------------
TH_1155|M.thermoresistible__bu LAQWDDVSRRMYVPFHDGIISQFEGYGELAELDWDGYRRRYGNIQRLDRI
Mvan_4107|M.vanbaalenii_PYR-1 LAHWDDVSRRMYVPFHDGVISQFEGYGDLADLDWDRLRRQYGNIQRLDRI
Mflv_4989|M.gilvum_PYR-GCK LAHWEDVSRRMFVPFHDGVITQFEGYDRLRELDWEAYRNRYDDLQRLDRI
Rv3372|M.tuberculosis_H37Rv -----------------------------PDVDWDKGKTLLWVLDHLPHS
Mb3407|M.bovis_AF2122/97 -----------------------------PDVDWDKGKTLLWVLDHLPHS
MLBr_00414|M.leprae_Br4923 -----------------------------PDIDWDKGKTLHWVIDRLHHA
MMAR_1156|M.marinum_M -----------------------------PDIDWDKGKTLRWVIDHLPDQ
MUL_0921|M.ulcerans_Agy99 -----------------------------PDIDWDKGKTLRWVIDHLPDQ
MAV_4338|M.avium_104 -----------------------------PDLDWDKGKTLHWVIEHLRRS
MAB_0578c|M.abscessus_ATCC_199 VQLDVFGPVVELIHDLSHARKHLGHSDPLTDADWNLVSDMVLAVERRWYE
MSMEG_6043|M.smegmatis_MC2_155 --------------------------------------------------
TH_1155|M.thermoresistible__bu LEAEGDDVNRYKASKQADALMLLYLLSADELRELLGHLGYRFTAEQIPGM
Mvan_4107|M.vanbaalenii_PYR-1 LEAENDDVNRYKASKQADALMLLYLLSADELREILDRLGYRFLPEQVPKM
Mflv_4989|M.gilvum_PYR-GCK LEAEGDSVNNYRAGKQADTLMLFYLLSADELYELFDRLGYNFAPEQIPAT
Rv3372|M.tuberculosis_H37Rv ---------------GSAPLVPIYLG------------------DDITDE
Mb3407|M.bovis_AF2122/97 ---------------GSAPLVPIYLG------------------DDITDE
MLBr_00414|M.leprae_Br4923 GTQV-----------GSASLMPICLG------------------DDITDE
MMAR_1156|M.marinum_M ---------------RAAPLVPIYLG------------------DDITDE
MUL_0921|M.ulcerans_Agy99 ---------------RAAPLVPIYLG------------------DDITDE
MAV_4338|M.avium_104 ---------------GSGALTPVYLG------------------DDITDE
MAB_0578c|M.abscessus_ATCC_199 PDHGIWEIRGNPRHHVYSKVMCWVTVDRAVKLAEEFERAAPSSWAALRDE
MSMEG_6043|M.smegmatis_MC2_155 --------------------------------------------------
TH_1155|M.thermoresistible__bu VDYYLARTSHGSTLSAVVHAWVLARANRDRAMEYFERVLKSDVADIQGGT
Mvan_4107|M.vanbaalenii_PYR-1 VDYYLARTSHGSTLSGVVHTWVLARANRNRALEFFQQALKSDVSDIQGGT
Mflv_4989|M.gilvum_PYR-GCK IDYYQKRTSHGSTLSAVVHSWVLARGDRREAMHYFRRVLASDVVDIQRGT
Rv3372|M.tuberculosis_H37Rv DAFDVVGP---HGVPIVVR--HTDDGDR---------------------A
Mb3407|M.bovis_AF2122/97 DAFDVVGP---HGVPIVVR--HTDDGDR---------------------A
MLBr_00414|M.leprae_Br4923 DAFDAVRHTDVGGIPIVVR--HTEDGNR---------------------A
MMAR_1156|M.marinum_M DAFDAVGP---NGVAIMVR--HNEDGDR---------------------A
MUL_0921|M.ulcerans_Agy99 DAFDAVGP---NGVAIMVR--HNEDGDR---------------------A
MAV_4338|M.avium_104 DAFDAVRGGPVQGVPILVR--HNDDGDR---------------------A
MAB_0578c|M.abscessus_ATCC_199 IAAEVIEKGWNESVNSYTAAYDGTDLDAATLYIGLSG--LIDPTDPRFTA
MSMEG_6043|M.smegmatis_MC2_155 --------------------------------------------------
TH_1155|M.thermoresistible__bu TAEGIHLAAMAGSVDLVQRCFTGLETRSDRIVLSPNWPESLGALGFPIRY
Mvan_4107|M.vanbaalenii_PYR-1 TSEGIHLAAMAGTVDLMQRCFTGLETRSNRIILSPYWPESLGVLAIPIHY
Mflv_4989|M.gilvum_PYR-GCK TAEGIHLAAMAGSIDLLQRCFTGLELRRDRIVVGPMWPEPLGRLAFTFRY
Rv3372|M.tuberculosis_H37Rv TAALFALDSPARVAEFTDRLARQLREAPLRAT------------------
Mb3407|M.bovis_AF2122/97 TAALFALDSPARVAEFTDRLARQLREAPLRAT------------------
MLBr_00414|M.leprae_Br4923 TAALFTLDSPMHVSEFTERLARQLSDTQR---------------------
MMAR_1156|M.marinum_M TAALFALESPARVAEFTGRLASQLSTLG----------------------
MUL_0921|M.ulcerans_Agy99 TAALFALESPARVAEFTGRLASQLSTLG----------------------
MAV_4338|M.avium_104 TAALFALDSPARAAEFTERLADQLERGEG---------------------
MAB_0578c|M.abscessus_ATCC_199 TVIATEAELRSGATVYRYHRDDCLPGGEGGFHLCAAWLVEAYLLIGARSQ
MSMEG_6043|M.smegmatis_MC2_155 --------------------------------------------------
TH_1155|M.thermoresistible__bu RGHQMYVRVSGRGAEISVAPRDLPPVAVECNGRVQRLEPGTTVRFT----
Mvan_4107|M.vanbaalenii_PYR-1 RGLHLHLRVSGKGVIISVDPRDAAGIEVECRGQVVQLMPGTTVRFPG---
Mflv_4989|M.gilvum_PYR-GCK RGHRLRLTVLGRSSTLSAEPSEASPILVECRGQAQTLVAGGTVEFTR---
Rv3372|M.tuberculosis_H37Rv --------------------------------------------------
Mb3407|M.bovis_AF2122/97 --------------------------------------------------
MLBr_00414|M.leprae_Br4923 --------------------------------------------------
MMAR_1156|M.marinum_M --------------------------------------------------
MUL_0921|M.ulcerans_Agy99 --------------------------------------------------
MAV_4338|M.avium_104 --------------------------------------------------
MAB_0578c|M.abscessus_ATCC_199 AELLFDQLVKATGPTGLLSEEYDPVAERSLGNHPQAYSHIGLLRCAALLS
MSMEG_6043|M.smegmatis_MC2_155 --------------------------------------------------