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MKSFTIDPRRHDGVIFVLDGDGHEQSIWEPTVALARKLWQVGVGTAVYSPTDESVRVLDAAGLSEPEQVS APPQASRAKPYCVGLSAAAAKLGAAVQRLAVVAGMDGGVEAARECGFAFVIGFDRDGRAEELLRRGADVV AADLAEVTVRTGDERLSQCPNALDSYGQVIGMVAGRQLFVCMDYDGTLSEIVSEPDAATLVDGAAEALAH LSTQCPVAILSGRDLTDIRDRVGVPGIWYAGSHGFELIAPDGTHHQHEAAAAAVDVLASAAKDLRHELAQ IPGVSVEHKRFGVAVHYRNVAREHVAQVIATTHRYRREYGLRVTSGRKVVELRPDIDWDKGAALAWIRSL IFEDSRVLPMYVGDDLTDEDAFDALRFSGVGIVVRHDEDGDRPTAANFTLRNPNEVRDFVRRGAGWLAHA HETQSRGWTFTFEGYDPPNEKLREALCTVGNGYFATRGAAPESKAGQVHYPGTYAGGVFNRLDDLIGGTR TAHESLVNLPNWLPLTFRIDGGDWFDVDAVTLLSYRQTLDLRGAVLTRELTFRDDAGRTSSVTQHRFVSM NQAHVAALQTTIVGHDWSGTIEIRSTIDGNVRNSGVERYRNLASNHLQGLQKAVLSENSVSMAVETTQSK IPVAVAARTSLWRADEPVAATYRLLDEEFEIGHEIFTEAKLGQPLTVEKIVTLVSGLDVATSHPAIGAER RLGRQGRFAEICDAHRIAWSHLWERLSIEFSNHTEELRVLRLHLLHLLQTVSYNSADLDVGVPARGLHGE AYRGHIFWDELFIFPVLNLRLPAVTRSLLLYRYRRLLEAQRAAKLAGYRGAMYPWQSGSDGREESPEQHL NPRSGRWIPDASHRAHHIGIAVAYNVWQFYQVTGDLAFMIDYGTEMMAEIARFWVSRATYDAERDRYHIK GVIGPDEFHSGYPDRPYDGVDDNAYTNVMAAWVILRAIDALLLMPLPNRLDLYEKLALTEEELAQWDHVS RRMFVPFHDGVISQFDGYEQLAELDWDAYRQRYGNIQRLDRILEAEDDDVNRYRASKQADALMLLYLLSA DELGELLDRLGYHMERDQIPEMVDYYMARTSHGSTLSAAVHGWVLARANRDRALEFFQQVLESDVADIQG GTTAEGVHLAAMAGSVDFVQRCFTGLEIRADRIVLSPHWPEYLGALGFPIHYRGNHLHLRVSGKGAEISV EPRDVPPVEVECHGRVERLLPGSTVRFS
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. marinum M | MMAR_2257 | otsB1 | - | 100% (1218) | trehalose-6-phosphate phosphatase OtsB1 |
M. marinum M | MMAR_1156 | otsB2 | e-104 | 50.00% (418) | trehalose-6-phosphate phosphatase OtsB2 |
M. marinum M | MMAR_1143 | - | 2e-47 | 26.61% (778) | glycosyl hydrolase |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb2029 | otsB1 | 0.0 | 59.09% (1193) | trehalose-6-phosphate phosphatase OtsB1 |
M. gilvum PYR-GCK | Mflv_4989 | - | 0.0 | 55.19% (1214) | HAD family hydrolase |
M. tuberculosis H37Rv | Rv2006 | otsB1 | 0.0 | 59.09% (1193) | trehalose-6-phosphate phosphatase OtsB1 |
M. leprae Br4923 | MLBr_00414 | otsB2 | 1e-105 | 51.05% (427) | putative trehalose-6-phosphate phosphatase |
M. abscessus ATCC 19977 | MAB_0578c | - | 2e-20 | 31.89% (254) | putative trehalose phosphatase |
M. avium 104 | MAV_4338 | - | 2e-99 | 50.24% (418) | glycosyl hydrolase |
M. smegmatis MC2 155 | MSMEG_3954 | - | 0.0 | 59.98% (867) | trehalose 6-phosphate phosphorylase |
M. thermoresistible (build 8) | TH_1155 | - | 0.0 | 69.30% (961) | trehalose 6-phosphate phosphorylase |
M. ulcerans Agy99 | MUL_0921 | otsB2 | 1e-103 | 49.76% (418) | trehalose-6-phosphate phosphatase OtsB2 |
M. vanbaalenii PYR-1 | Mvan_4107 | - | 0.0 | 66.34% (1218) | HAD family hydrolase |
CLUSTAL 2.0.9 multiple sequence alignment MLBr_00414|M.leprae_Br4923 -------------------------------------------------- MUL_0921|M.ulcerans_Agy99 -------------------------------------------------- MAV_4338|M.avium_104 -------------------------------------------------- Mb2029|M.bovis_AF2122/97 MRCGIVVNVTGPPPTIDRRYHDAVIVGLDNVVDKATRVHAAAWTKFLDDY Rv2006|M.tuberculosis_H37Rv MRCGIVVNVTGPPPTIDRRYHDAVIVGLDNVVDKATRVHAAAWTKFLDDY MMAR_2257|M.marinum_M ----------MKSFTIDPRRHDGVIFVLDGDGHEQS-IWEPTV------- TH_1155|M.thermoresistible__bu -------------------------------------------------- Mvan_4107|M.vanbaalenii_PYR-1 ---------MKLPVTIDPRYHDAVLLDLDGALTSEAPLFGPTV------- MSMEG_3954|M.smegmatis_MC2_155 -------------------------------------------------- Mflv_4989|M.gilvum_PYR-GCK -----------MPVFIDPRHHDAVIFEVDDPVADEVALSASQG------- MAB_0578c|M.abscessus_ATCC_199 -------------------------------------------------- MLBr_00414|M.leprae_Br4923 -------------------------------------------------- MUL_0921|M.ulcerans_Agy99 -------------------------------------------------- MAV_4338|M.avium_104 -------------------------------------------------- Mb2029|M.bovis_AF2122/97 LTRRPQRTGEDHCPLTHDDYRRFLAGKPDSVADFLAARGIRLPPGSPTDL Rv2006|M.tuberculosis_H37Rv LTRRPQRTGEDHCPLTHDDYRRFLAGKPDGVADFLAARGIRLPPGSPTDL MMAR_2257|M.marinum_M -------------------------------------------------- TH_1155|M.thermoresistible__bu -------------------------------------------------- Mvan_4107|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_3954|M.smegmatis_MC2_155 -------------------------------------------------- Mflv_4989|M.gilvum_PYR-GCK -------------------------------------------------- MAB_0578c|M.abscessus_ATCC_199 -------------------------------------------------- MLBr_00414|M.leprae_Br4923 -------------------------------------------------- MUL_0921|M.ulcerans_Agy99 -------------------------------------------------- MAV_4338|M.avium_104 -------------------------------------------------- Mb2029|M.bovis_AF2122/97 TDDTVYGLQNLERQTFLQLLNTGVPEGKSIASFARRLQVAGVRVAAHTSH Rv2006|M.tuberculosis_H37Rv TDDTVYGLQNLERQTFLQLLNTGVPEGKSIASFARRLQVAGVRVAAHTSH MMAR_2257|M.marinum_M -------------------------------ALARKLWQVGVGTAVYSPT TH_1155|M.thermoresistible__bu -------------------------------------------------- Mvan_4107|M.vanbaalenii_PYR-1 -------------------------------DLARKLQSIGVAAAAYSSN MSMEG_3954|M.smegmatis_MC2_155 -------------------------------------------------- Mflv_4989|M.gilvum_PYR-GCK -------------------------------DLARRLTAAGIGVGCAES- MAB_0578c|M.abscessus_ATCC_199 -------------------------------------------------- MLBr_00414|M.leprae_Br4923 -------------------------------------------------- MUL_0921|M.ulcerans_Agy99 -------------------------------------------------- MAV_4338|M.avium_104 -------------------------------------------------- Mb2029|M.bovis_AF2122/97 RNYGHTLDATGLAEVFAVFVDGAVTAELGLPAEPNPAGLIETAKRLGANP Rv2006|M.tuberculosis_H37Rv RNYGHTLDATGLAEVFAVFVDGAVTAELGLPAEPNPAGLIETAKRLGANP MMAR_2257|M.marinum_M DESVRVLDAAGLSEPEQVSAP-----PQASRAKPYCVGLSAAAAKLGAAV TH_1155|M.thermoresistible__bu -------------------------------------------------- Mvan_4107|M.vanbaalenii_PYR-1 GQCRQALKAAGIDDLFGVCID-GMEGDRGTAEKPDPAVLLEAARRIGARP MSMEG_3954|M.smegmatis_MC2_155 -------------------------------------------------- Mflv_4989|M.gilvum_PYR-GCK ------------------------------------AMLRETARRLGVHP MAB_0578c|M.abscessus_ATCC_199 -------------------------------------------------- MLBr_00414|M.leprae_Br4923 -------------------------------------------------- MUL_0921|M.ulcerans_Agy99 -------------------------------------------------- MAV_4338|M.avium_104 -------------------------------------------------- Mb2029|M.bovis_AF2122/97 GRCVVIDSCQTGLRAGRNGGFALVIAVDAHGDAENLLSSGADAVVADLAA Rv2006|M.tuberculosis_H37Rv GRCVVIDSCQTGLRAGRNGGFALVIAVDAHGDAENLLSSGADAVVADLAA MMAR_2257|M.marinum_M QRLAVVAGMDGGVEAARECGFAFVIGFDRDGRAEELLRRGADVVAADLAE TH_1155|M.thermoresistible__bu -------------------------------------------------- Mvan_4107|M.vanbaalenii_PYR-1 QRCVVVENSAAGVAAGRAGGFALVVGIDGTEVADELTRHGADVVLAGLAD MSMEG_3954|M.smegmatis_MC2_155 -------------------------------------------------- Mflv_4989|M.gilvum_PYR-GCK GRCVVVAGGEAGVRTARAGGFALIVGIDRAERAEDLRSCGADVVVPDLVA MAB_0578c|M.abscessus_ATCC_199 -------------------------------------------------- MLBr_00414|M.leprae_Br4923 -------------------------------------------------- MUL_0921|M.ulcerans_Agy99 -------------------------------------------------- MAV_4338|M.avium_104 -------------------------------------------------- Mb2029|M.bovis_AF2122/97 VTVGSGDAAISTIPDALQVYSQLKRLLTGRRPAVFLDFDGTLSDIVERPE Rv2006|M.tuberculosis_H37Rv VTVGSGDAAISTIPDALQVYSQLKRLLTGRRPAVFLDFDGTLSDIVERPE MMAR_2257|M.marinum_M VTVRTGDERLSQCPNALDSYGQVIGMVAGRQLFVCMDYDGTLSEIVSEPD TH_1155|M.thermoresistible__bu ------------LSNALASYGLLIGIVANRQPVVFCRFDGAL----ADRD Mvan_4107|M.vanbaalenii_PYR-1 IAVRTGDRRISELPNALASYGQLIGITSARESMLFLDYDGTLSPIVSDPA MSMEG_3954|M.smegmatis_MC2_155 ---------------------------------MEHHTDAAQDDVVTDDE Mflv_4989|M.gilvum_PYR-GCK VTVRDGYRRMSELADALQSYGEIVPLAETRTPVVLLDFDGTLSDIVGDPD MAB_0578c|M.abscessus_ATCC_199 --------MVSAQDLPVELRRALSEVARTPRLLVASDYDGTIAPLVNNPD MLBr_00414|M.leprae_Br4923 -------------------------------------------------- MUL_0921|M.ulcerans_Agy99 -------------------------------------------------- MAV_4338|M.avium_104 -------------------------------------------------- Mb2029|M.bovis_AF2122/97 AATLVDGAAEALRALA--AQCPVAVISGRDLADVRNRVKVDGLWLAGSHG Rv2006|M.tuberculosis_H37Rv AATLVDGAAEALRALA--AQCPVAVISGRDLADVRNRVKVDGLWLAGSHG MMAR_2257|M.marinum_M AATLVDGAAEALAHLS--TQCPVAILSGRDLTDIRDRVGVPGIWYAGSHG TH_1155|M.thermoresistible__bu TATLVDGAAAALRKLA--SLCPVAVISGREVSELRARVGVDGLWYAGGHG Mvan_4107|M.vanbaalenii_PYR-1 AARLVEGADEALELVS--KVCPVAILSGRDLADVSARVGTPGVWYAGSHG MSMEG_3954|M.smegmatis_MC2_155 DRRPIADLPDALDHFD--EIR--------DLLAFRN-------------- Mflv_4989|M.gilvum_PYR-GCK TAALVPGARSVLDALA--ARCPVAVVSGRALADIRDRIGVPGIWYAGSHG MAB_0578c|M.abscessus_ATCC_199 HARPHPESTTALRALAGLPSTTSALISGRALRDLATLSRLPSEVHLVGSH MLBr_00414|M.leprae_Br4923 -------------------------------------------------- MUL_0921|M.ulcerans_Agy99 -------------------------------------------------- MAV_4338|M.avium_104 -------------------------------------------------- Mb2029|M.bovis_AF2122/97 FELVAPDGSHHQNAAATAAIDGLAEAAAQLADALREIAGAVVEHKRFAVA Rv2006|M.tuberculosis_H37Rv FELVAPDGSHHQNAAATAAIDGLAEAAAQLADALREIAGAVVEHKRFAVA MMAR_2257|M.marinum_M FELIAPDGTHHQHEAAAAAVDVLASAAKDLRHELAQIPGVSVEHKRFGVA TH_1155|M.thermoresistible__bu REVVAPDGSHHRFDG----------------------------------- Mvan_4107|M.vanbaalenii_PYR-1 FELTSPDGAYHCNDAAAVFVPVLEEAAAELNKTLAQIAGVRVEHKRFAVA MSMEG_3954|M.smegmatis_MC2_155 -------------------------------------------------- Mflv_4989|M.gilvum_PYR-GCK FELCSPDGGIQENEAGLEIVRVLAGALAEVRERVGAVDGVLIEDKRFSIA MAB_0578c|M.abscessus_ATCC_199 GSEFDAGFVHAIDG------------------------------------ MLBr_00414|M.leprae_Br4923 -------------------------------------------------- MUL_0921|M.ulcerans_Agy99 -------------------------------------------------- MAV_4338|M.avium_104 -------------------------------------------------- Mb2029|M.bovis_AF2122/97 VHYRNVADDSVDNLIAAVRRLGHAAGLRVTTGRKVVELRPDIAWDKGKAL Rv2006|M.tuberculosis_H37Rv VHYRNVADDSVDNLIAAVRRLGHAAGLRVTTGRKVVELRPDIAWDKGKAL MMAR_2257|M.marinum_M VHYRNVAREHVAQVIATTHRYRREYGLRVTSGRKVVELRPDIDWDKGAAL TH_1155|M.thermoresistible__bu -----------------------------------------TDWDPGAAL Mvan_4107|M.vanbaalenii_PYR-1 VHYREVAPEQVSEIVSATHQLGARRGLRVTSGRMLVELRPDLDWDKGTTL MSMEG_3954|M.smegmatis_MC2_155 -------------------------------------------------- Mflv_4989|M.gilvum_PYR-GCK VHYRNVAAESVDEVVTAVRNIAQCNGLRADGGRRVVELKPDTGWHKGRAV MAB_0578c|M.abscessus_ATCC_199 -------------------------------------------------- MLBr_00414|M.leprae_Br4923 -------------------------------------------------- MUL_0921|M.ulcerans_Agy99 -------------------------------------------------- MAV_4338|M.avium_104 -------------------------------------------------- Mb2029|M.bovis_AF2122/97 DWIGERLGPAEVGPDLRLPIYIGDDLTDEDAFDAVRFTGVGIVVR-HNEH Rv2006|M.tuberculosis_H37Rv DWIGERLGPAEVGPDLRLPIYIGDDLTDEDAFDAVRFTGVGIVVR-HNEH MMAR_2257|M.marinum_M AWIRSLIF----EDSRVLPMYVGDDLTDEDAFDALRFSGVGIVVR-HDED TH_1155|M.thermoresistible__bu TSIRARMG----RPEPVLPIYVGSELADEAAFDVLRLDGVSVVVH-HLGA Mvan_4107|M.vanbaalenii_PYR-1 AWIRDRID----PSGSLLPIYIGDDLTDEDAFDAVRFDGIGIVVG-HDED MSMEG_3954|M.smegmatis_MC2_155 --------------PASLPVFIG-NPADDSAFRTVRRDGIGIVVVTHAED Mflv_4989|M.gilvum_PYR-GCK EWILDRID----GDELLLPVYIGDDLTDEDGFDAVRLRGIGVAVR-SAES MAB_0578c|M.abscessus_ATCC_199 -----------------DAKALLKTIATKLSAIAAEYPGVAIELKPASVA MLBr_00414|M.leprae_Br4923 -------------------------------------------------- MUL_0921|M.ulcerans_Agy99 -------------------------------------------------- MAV_4338|M.avium_104 -------------------------------------------------- Mb2029|M.bovis_AF2122/97 GDRRSAATFRLECPYTVCQFLSQLACDLQEAVQHDDP-WTLVFHGYDPGQ Rv2006|M.tuberculosis_H37Rv GDRRSAATFRLECPYTVCQFLSQLACDLQEAVQHDDP-WTLVFHGYDPGQ MMAR_2257|M.marinum_M GDRPTAANFTLRNPNEVRDFVRRGAGWLAHAHETQSRGWTFTFEGYDPPN TH_1155|M.thermoresistible__bu ADRPTGAQFRLDGAEEVCEFLRRGGNWIAYQRQTSNEAWTFSYRGYDPRQ Mvan_4107|M.vanbaalenii_PYR-1 GDRKTAANFTLQSPEQVREFIQRGSRWLAYKHQVSGEAWDYVFDGYDPQN MSMEG_3954|M.smegmatis_MC2_155 EKRSTTATFRLDSPGAAATFRHR-LAQEADRPTSIDPGWVLTFDGYDPAN Mflv_4989|M.gilvum_PYR-GCK GDRRSAARFALDSPAAVCAFLARLSDQLAVEQDLTNDPWTLTFGGYLPED MAB_0578c|M.abscessus_ATCC_199 LHVRNAS-----EEDADAALRQALSVANGWGAQVTEGKKVLEFAVIPTDK MLBr_00414|M.leprae_Br4923 -------------------------------------------------- MUL_0921|M.ulcerans_Agy99 -------------------------------------------------- MAV_4338|M.avium_104 -------------------------------------------------- Mb2029|M.bovis_AF2122/97 ERLREALCAVGNGYLGSRGCAPESAESEAHYPGTYVAGVYNQLTDHIEGC Rv2006|M.tuberculosis_H37Rv ERLREALCAVGNGYLGSRGCAPESAESEAHYPGTYVAGVYNQLTDHIEGC MMAR_2257|M.marinum_M EKLREALCTVGNGYFATRGAAPESKAGQVHYPGTYAGGVFNRLDDLIGGT TH_1155|M.thermoresistible__bu EKLREALCTVGNGYFATRGAAPEARAGQVHYPGTYAAGVFNRLDDVVDGR Mvan_4107|M.vanbaalenii_PYR-1 EKLREALCTVGNGYFATRGAAPESKAGQVHYPGTYAAGVYNRLVDNVSGT MSMEG_3954|M.smegmatis_MC2_155 ERFREALCTLGNGYFATRGCAPEAPAGRFHYPGTYVAGIYNRLTDEIAGH Mflv_4989|M.gilvum_PYR-GCK ERLREALCTLGNGYLATRGAAPECDASRLHYPATYVAGIYNRLFDEIAGT MAB_0578c|M.abscessus_ATCC_199 GQALDILRHQEGATAAVFFGDDVTDEKAFKRLHGPDVGVKVGDGETLAGY MLBr_00414|M.leprae_Br4923 -----------------------------------MPVTIDPRRHSAA-- MUL_0921|M.ulcerans_Agy99 -----------------------------------MSVTIDPRRH----- MAV_4338|M.avium_104 -------------------------------MGESGPVVIDPRRH----- Mb2029|M.bovis_AF2122/97 TVDNESLVNLPNWLSLTFRIDGGAWFNVDTVELLSYRQTFDLRRATLTRS Rv2006|M.tuberculosis_H37Rv TVDNESLVNLPNWLSLTFRIDGGAWFNVDTVELLSYRQTFDLRRATLTRS MMAR_2257|M.marinum_M RTAHESLVNLPNWLPLTFRIDGGDWFDVDAVTLLSYRQTLDLRGAVLTRE TH_1155|M.thermoresistible__bu VTAHESMVNLPNWLPLTFRIEGGPWFDVDAVTLLDYRQTLDLRGAVLTRE Mvan_4107|M.vanbaalenii_PYR-1 EIDNESLVNLPNWLALTFRVDHGDWFDIDAVTVLSYRQTLDLRGAVLTRQ MSMEG_3954|M.smegmatis_MC2_155 RTDNESLVNLPNWLALTFRFDDGPWLDVDDTDLQSYQQTLDLRRGVLTRQ Mflv_4989|M.gilvum_PYR-GCK TVDNESLVNLPNWLPVTFRVDGGAWFDIDAVEFTSYVTTLDLRRATLTRE MAB_0578c|M.abscessus_ATCC_199 RIPDTESVGT----ALAFLLEERRTWLLGGHATPIERLTMLANSRTIALV .: . MLBr_00414|M.leprae_Br4923 -LFDLDAVVTDTPLDSTVTLVRQLQGIGVGTAVFSTNRNSQGVLTATGLD MUL_0921|M.ulcerans_Agy99 -----DAVLFDTALNSTQALVRQLQQARVGTATFASG------------- MAV_4338|M.avium_104 -----DAVLFGVGDALGSALASQLGQIGVGTAAIAAD------------- Mb2029|M.bovis_AF2122/97 LRFRDAGGRVTTMTQERFASMNRPNLVALQTRIESENWSGTVDFRSLVDG Rv2006|M.tuberculosis_H37Rv LRFRDAGGRVTTMTQERFASMNRPNLVALQTRIESENWSGTVDFRSLVDG MMAR_2257|M.marinum_M LTFRDDAGRTSSVTQHRFVSMNQAHVAALQTTIVGHDWSGTIEIRSTIDG TH_1155|M.thermoresistible__bu LRFRDNAGRTTSVTQQRFVAMHTAHIAALETTLVAEDWSGTVDVRSTLDG Mvan_4107|M.vanbaalenii_PYR-1 VRFRDHAGRTSSLTQRRFVAMHLPHAGALETTVVAEDWSGTIEFRSTVDG MSMEG_3954|M.smegmatis_MC2_155 FRFCDKAGRVATVTQHRLVAMHLPHLAMLQTMVTAENFSGTVEFRSEIDG Mflv_4989|M.gilvum_PYR-GCK FVMRDQAGRITRIRQRRLVAMHRPHVAAMATTVRAENWSGRLQLRSVLDG MAB_0578c|M.abscessus_ATCC_199 TPTGDVTWMCHPEPDSAAVFAHLLGGPEAGHFTIGPARSALP----LGQK . . MLBr_00414|M.leprae_Br4923 HLFPVHVDGLASGKVTILVAAANRLMAQPGRCVVVAVDAAGITAARYG-- MUL_0921|M.ulcerans_Agy99 -------GGGHDAAIQALIESADRVGARPGRCVVITADAASVAAARDS-- MAV_4338|M.avium_104 ----------------DPAAAADRLRVRPGRCVVVAGDPAAVEAARAA-- Mb2029|M.bovis_AF2122/97 GVHNTLVDRYRQLSSQHLTTAEIEVLA-DSVLLRTQTSQSGIAIAVAARS Rv2006|M.tuberculosis_H37Rv GVHNTLVDRYRQLSSQHLTTAEIEVLA-DSVLLRTQTSQSGIAIAVAARS MMAR_2257|M.marinum_M NVRNSGVERYRNLASNHLQGLQKAVLSENSVSMAVETTQSKIPVAVAART TH_1155|M.thermoresistible__bu DVRNGLVERYRDLRGDHLESLGKSALTGDSVLLSVRTNQSRIPIAMAART Mvan_4107|M.vanbaalenii_PYR-1 NVTNSLVERYRDLANEHLDSADTQELSNNSVLLTMQTNQSRIPIAMAARN MSMEG_3954|M.smegmatis_MC2_155 AVTNSLVERYRDLSNVHLVGHEKRSLTADSLLLTAHTCQSHIRVAVALRN Mflv_4989|M.gilvum_PYR-GCK GVENLGVERYRALSSRHLTVDAMRELSRDAVLLQTHTGESQIQIAVAARH MAB_0578c|M.abscessus_ATCC_199 YIDSTMTVETRWASLQVTDYLAHDEVPGRTDLIRVVTGEADAVVTFAPR- : : : MLBr_00414|M.leprae_Br4923 ----------------------GFALVLGLVIGEDQTGHRDTLRNSGADT MUL_0921|M.ulcerans_Agy99 ----------------------GFALVIG----VDQAGHRDALPDHGADT MAV_4338|M.avium_104 ----------------------GFALVIG---LAPDGRDGDGLRAAGADA Mb2029|M.bovis_AF2122/97 TLWRDGQRVDAQYRVARDTNRGGHDIQVTLSAGQSVTLEKVATIFTSRDA Rv2006|M.tuberculosis_H37Rv TLWRDGQRVDAQYRVARDTNRGGHDIQVTLSAGQSVTLEKVATIFTSRDA MMAR_2257|M.marinum_M SLWRADEPVAATYRLLDEEFEIGHEIFTEAKLGQPLTVEKIVTLVSGLDV TH_1155|M.thermoresistible__bu TAWRDGDPVSAGYRLVDEESEIGHQITTGLSRGQRLTVEKVVALSTGRDV Mvan_4107|M.vanbaalenii_PYR-1 TVWRDGEPVPAAFALFDQGAEIGHDIAVHLSAGDAVTLEKVVTVYTGRDV MSMEG_3954|M.smegmatis_MC2_155 TVWRGDSPARADYTLVDDRRRAGHVISCYIEAGQPVTLEKAVSVATSRDH Mflv_4989|M.gilvum_PYR-GCK RVT-GGEPESVDQRVFRDDCRIGHDIEVVVTAGQAVTLEKVIAVYTGRDH MAB_0578c|M.abscessus_ATCC_199 ------------------------PEFGQAPVQLVAEADGLRVLGTNDPI . . MLBr_00414|M.leprae_Br4923 VVADLGEVIVRTGDR--RMSELPDALQTL-------------GLTDDLTA MUL_0921|M.ulcerans_Agy99 VLADLDEVRVRAGDR--HMSELPDALQAL-------------GRPDGLTV MAV_4338|M.avium_104 VIAELEQITVRTGDR--RMSQLPDASQALT------------GGADGLAG Mb2029|M.bovis_AF2122/97 ATLTAAISAQRCLGEAGRYAELCQQHVRAWARLWERCAIDLTGNTEELRL Rv2006|M.tuberculosis_H37Rv ATLTAAISAQRCLGEAGRYAELCQQHVRAWARLWERCAIDLTGNTEELRL MMAR_2257|M.marinum_M ATSHPAIGAERRLGRQGRFAEICDAHRIAWSHLWERLSIEFSNHTEELRV TH_1155|M.thermoresistible__bu GSSEPSESAERILERQGRFGEIRAAHTVAWAHLWRRLSIEFEDHTDELRV Mvan_4107|M.vanbaalenii_PYR-1 AISEPGVNAQRWVTRLGRFDELLDGHRTAWTHLWERLSIDFDDFTDELRI MSMEG_3954|M.smegmatis_MC2_155 ATCEAANEATRRLQWVDRYHDVQQAHTTAWGQLWERFDVDIGGRTDELRT Mflv_4989|M.gilvum_PYR-GCK GMSGPVTAAEREIAGADTFDRLEDGHRLAWAHLWERFNIDMGHDPNLLRL MAB_0578c|M.abscessus_ATCC_199 VLRAPGVTWTIGADDQTATATISPANGPIILELRCGTEDLGENPTSEPEL : .. MLBr_00414|M.leprae_Br4923 RQPAVFFDFDGTLSDIVDDPDSARPVPGATEALQK-------------LA MUL_0921|M.ulcerans_Agy99 PRPAVFFDFDGTLSEIVDDPDAATPTAGAVAALQQ-------------LA MAV_4338|M.avium_104 RHPAVFFDFDGTLSDIVDDPDAARPVAGATAALTR-------------LA Mb2029|M.bovis_AF2122/97 VRLHLLHLLQ-TISPHTAELDAGVPARGLNGEAYRGHVFWDALFVAPVLS Rv2006|M.tuberculosis_H37Rv VRLHLLHLLQ-TISPHTAELDAGVPARGLNGEAYRGHVFWDALFVAPVLS MMAR_2257|M.marinum_M LRLHLLHLLQ-TVSYNSADLDVGVPARGLHGEAYRGHIFWDELFIFPVLN TH_1155|M.thermoresistible__bu MRLHLLHLLQ-TVSPHSADLDIGPPARGLHGEAYRGHIFWDELFIFPVLN Mvan_4107|M.vanbaalenii_PYR-1 LRLHLLHLLQ-TVSLNTADLDAGVPARGLHGEAYRGHIFWDELFIFPVLN MSMEG_3954|M.smegmatis_MC2_155 VRLHLLHTLQ-TLSPHVRDLDIGVPARGLTGEAYRGHIFWDELFVAPVVS Mflv_4989|M.gilvum_PYR-GCK VRLHQLHLLQ-TLSPHTADLDVGVPARGLHGEAYRGHVFWDELFVFPVLN MAB_0578c|M.abscessus_ATCC_199 RERAESYWRDWAQTLTLPERKPGLMKR--SALTLRGLVHAESGAILAAAT . . : : : : . . : MLBr_00414|M.leprae_Br4923 THCPVAILS-----------GRDLADVIKRIGVPGIWYSGSHGFEST--- MUL_0921|M.ulcerans_Agy99 AQCPVAILS-----------GRDLADVSQRVGLPGIWYAGSHGFELT--- MAV_4338|M.avium_104 ARCPVAVLS-----------GRDLADVTKRVGVPGIWYAGSHGFELT--- Mb2029|M.bovis_AF2122/97 LRMPKVARSLLDYRYRRLPAARRAAHRAGHLGAMYPWQSGSDGSEVSQQL Rv2006|M.tuberculosis_H37Rv LRMPKVARSLLDYRYRRLPAARRAAHRAGHLGAMYPWQSGSDGSEVSQQL MMAR_2257|M.marinum_M LRLPAVTRSLLLYRYRRLLEAQRAAKLAGYRGAMYPWQSGSDGREESPEQ TH_1155|M.thermoresistible__bu LRFPMITRSLLQYRYRRLPEARRAARLAGYRGAIFPWQSGSDGREESPEL Mvan_4107|M.vanbaalenii_PYR-1 LRAPMITRSLLGYRYRRLPEARHAARAAGHSGAMFPWQSGSDGREESQRL MSMEG_3954|M.smegmatis_MC2_155 LRRPALTRALLAYRHRRLPEARRAARDAGFTGAMFPWQSGSNGREESPAL Mflv_4989|M.gilvum_PYR-GCK MRLPKVTRSLLLYRYRRLPEARRAAAEAGYAGAMFPWQSGSDGREESQRL MAB_0578c|M.abscessus_ATCC_199 TSLPEDIGGIRNWDYR--YCWLRDASMTASALVALGSLSEAEGLLGWLHR * . * : :.* MLBr_00414|M.leprae_Br4923 ---------APDGT---HHQNDAAEATIPILEQAATQLRDQLGPIPGVMV MUL_0921|M.ulcerans_Agy99 ---------APDGT---HHQNEAAAAAIPVLEQAAAQLRDRLGSIPGVMV MAV_4338|M.avium_104 ---------APDGS---HHQNDDAAAAIPVLAQAAGRLSDELGTIPGVVV Mb2029|M.bovis_AF2122/97 HLNPRSGRWTPDPSDRAHHVGLAVAYNAWHYYQVTGDRQYLVDCGAELLV Rv2006|M.tuberculosis_H37Rv HLNPRSGRWTPDPSDRAHHVGLAVAYNAWHYYQVTGDRQYLVDCGAELLV MMAR_2257|M.marinum_M HLNPRSGRWIPDASHRAHHIGIAVAYNVWQFYQVTGDLAFMIDYGTEMMA TH_1155|M.thermoresistible__bu HLNPRSGRWNSDPSHRAHHIGIAIAYNVWQFYQVTGDLAYLIDHGAELLV Mvan_4107|M.vanbaalenii_PYR-1 HLNPRSGRWNPDASARAHHIGIAVAYSAWKFYQVTGDLAYLIDYGAELIA MSMEG_3954|M.smegmatis_MC2_155 HLNPRSGRWNPDPSALAHHVGLAVAYNIWQYYQVTDDLEYLIDYGAETLL Mflv_4989|M.gilvum_PYR-GCK HLNPRSGRWNPDASARAHHVGLAIAFNIWQHYQVTGDIGFLIDYGAEMLV MAB_0578c|M.abscessus_ATCC_199 VLEHLPGPDRLHPLYTLAGTALPPEAVIDSLPGYAGSRPVRVGNAANSQV . : :. . MLBr_00414|M.leprae_Br4923 EHKRFGVAVHYRNVARDR-------------------------------V MUL_0921|M.ulcerans_Agy99 EHKRFGVATHYRNAARNR-------------------------------V MAV_4338|M.avium_104 EHKRFGVAVHYRNAARDR-------------------------------V Mb2029|M.bovis_AF2122/97 EIARFWVGLAKLDDSRGRYLIRGVIGPDEFHSGYPGNEYDGIDNNAYTNV Rv2006|M.tuberculosis_H37Rv EIARFWVGLAKLDDSRGRYLIRGVIGPDEFHSGYPGNEYDGIDNNAYTNV MMAR_2257|M.marinum_M EIARFWVSRATYDAERDRYHIKGVIGPDEFHSGYPDRPYDGVDDNAYTNV TH_1155|M.thermoresistible__bu EIARFWVSRAEFDTRRGRYRIRGVIGPDEFHAGYPDRPFDGVDDNAYTNV Mvan_4107|M.vanbaalenii_PYR-1 EVARFFVSLASYDEDRERFGIKGVIGPDEFHSGYPEAPYDGIDNNAYTNV MSMEG_3954|M.smegmatis_MC2_155 EIARFWAGLALFSRERGRYVIPGVIGPDEFHTGYPGRLYDGIDNNAYTNV Mflv_4989|M.gilvum_PYR-GCK EITKFWVSAANLDPHRDRYVIRGVIGPDEFHSGYPGREYDGVDNNAYTNL MAB_0578c|M.abscessus_ATCC_199 QLDVFGPVVELIHDLSHARKHLG--------------------------- : * MLBr_00414|M.leprae_Br4923 NEVAVAVRTAGQRNALRVTTGREVIELR---------------------- MUL_0921|M.ulcerans_Agy99 GKIAAVVRAAGQRDGLRVTTGREVIELH---------------------- MAV_4338|M.avium_104 GEVAAAVRAAGRHDALRVTTGREVIELR---------------------- Mb2029|M.bovis_AF2122/97 MAVWVILRAMEALDLLPLTDRRHLIEKLGLTTQERDQWDDVSRRMFVPFH Rv2006|M.tuberculosis_H37Rv MAVWVILRAMEALDLLPLTDRRHLIEKLGLTTQERDQWDDVSRRMFVPFH MMAR_2257|M.marinum_M MAAWVILRAIDALLLMPLPNRLDLYEKLALTEEELAQWDHVSRRMFVPFH TH_1155|M.thermoresistible__bu MAVWVILRALEALNLIPLPNRIDVREKLNLTAAELAQWDDVSRRMYVPFH Mvan_4107|M.vanbaalenii_PYR-1 MAVWVIMRAIDALNLLPLPNRLDLLEALGLHNEELAHWDDVSRRMYVPFH MSMEG_3954|M.smegmatis_MC2_155 MAVWVILRALDALDAMPLADRTALLERLGLHGDELDKWEDVSHRMFVPFH Mflv_4989|M.gilvum_PYR-GCK MAVWVIVRTLEALERLPLSYRLALLETVGVGDEDLAHWEDVSRRMFVPFH MAB_0578c|M.abscessus_ATCC_199 HSDPLTDADWNLVSDMVLAVERRWYEPDHG-------------------- : :. * MLBr_00414|M.leprae_Br4923 -------------PDIDWDKGKTLHWVIDRLHHAGTQV-----------G MUL_0921|M.ulcerans_Agy99 -------------PDIDWDKGKTLRWVIDHLPDQ---------------R MAV_4338|M.avium_104 -------------PDLDWDKGKTLHWVIEHLRRS---------------G Mb2029|M.bovis_AF2122/97 DGVISQFEGYSELAELDWDHYRHRYGNIQRLDRILEAEGDSVNNYQASKQ Rv2006|M.tuberculosis_H37Rv DGVISQFEGYSELAELDWDHYRHRYGNIQRLDRILEAEGDSVNNYQASKQ MMAR_2257|M.marinum_M DGVISQFDGYEQLAELDWDAYRQRYGNIQRLDRILEAEDDDVNRYRASKQ TH_1155|M.thermoresistible__bu DGIISQFEGYGELAELDWDGYRRRYGNIQRLDRILEAEGDDVNRYKASKQ Mvan_4107|M.vanbaalenii_PYR-1 DGVISQFEGYGDLADLDWDRLRRQYGNIQRLDRILEAENDDVNRYKASKQ MSMEG_3954|M.smegmatis_MC2_155 NGVISQFEGYESLVELDWDRYRHEYGNIQRLDRILEAENDNVNRYKASKQ Mflv_4989|M.gilvum_PYR-GCK DGVITQFEGYDRLRELDWEAYRNRYDDLQRLDRILEAEGDSVNNYRAGKQ MAB_0578c|M.abscessus_ATCC_199 ------------IWEIRGNPRHHVYSKVMCWVTVDR-------------A :: : : : MLBr_00414|M.leprae_Br4923 SASLMPICLG-----DDITDEDAFDAVRHTDVGGIPIVVRHTEDGNRATA MUL_0921|M.ulcerans_Agy99 AAPLVPIYLG-----DDITDEDAFDAVGP---NGVAIMVRHNEDGDRATA MAV_4338|M.avium_104 SGALTPVYLG-----DDITDEDAFDAVRGGPVQGVPILVRHNDDGDRATA Mb2029|M.bovis_AF2122/97 ADALMLLYLLSSDELIGLLARLGYRFAPTQIPGTVDYYLARTSDGSTLSA Rv2006|M.tuberculosis_H37Rv ADALMLLYLLSSDELIGLLARLGYRFAPTQIPGTVDYYLARTSDGSTLSA MMAR_2257|M.marinum_M ADALMLLYLLSADELGELLDRLGYHMERDQIPEMVDYYMARTSHGSTLSA TH_1155|M.thermoresistible__bu ADALMLLYLLSADELRELLGHLGYRFTAEQIPGMVDYYLARTSHGSTLSA Mvan_4107|M.vanbaalenii_PYR-1 ADALMLLYLLSADELREILDRLGYRFLPEQVPKMVDYYLARTSHGSTLSG MSMEG_3954|M.smegmatis_MC2_155 ADVLMLFYLLSADEIRELLARLGYRFTPKQIPETVDYYLSRTSHGSTLSA Mflv_4989|M.gilvum_PYR-GCK ADTLMLFYLLSADELYELFDRLGYNFAPEQIPATIDYYQKRTSHGSTLSA MAB_0578c|M.abscessus_ATCC_199 VKLAEEFERAAPSSWAALRDEIAAEVIEKGWNESVNSYTAAY-DGTDLDA . : . . : .* . MLBr_00414|M.leprae_Br4923 ALFTLDSP-----MHVSEFTERLARQLSDTQR------------------ MUL_0921|M.ulcerans_Agy99 ALFALESP-----ARVAEFTGRLASQLSTLG------------------- MAV_4338|M.avium_104 ALFALDSP-----ARAAEFTERLADQLERGEG------------------ Mb2029|M.bovis_AF2122/97 VVHAWVLARANRSNAMEYFRQVLRSDIADVQGGTTQEGIHLAAMAGSIDL Rv2006|M.tuberculosis_H37Rv VVHAWVLARANRSNAMEYFRQVLRSDIADVQGGTTQEGIHLAAMAGSIDL MMAR_2257|M.marinum_M AVHGWVLARANRDRALEFFQQVLESDVADIQGGTTAEGVHLAAMAGSVDF TH_1155|M.thermoresistible__bu VVHAWVLARANRDRAMEYFERVLKSDVADIQGGTTAEGIHLAAMAGSVDL Mvan_4107|M.vanbaalenii_PYR-1 VVHTWVLARANRNRALEFFQQALKSDVSDIQGGTTSEGIHLAAMAGTVDL MSMEG_3954|M.smegmatis_MC2_155 VVHSWVLARGHREQAMEFFVQALNSDVADIQGGTTAEGIHLAAMAGSVDL Mflv_4989|M.gilvum_PYR-GCK VVHSWVLARGDRREAMHYFRRVLASDVVDIQRGTTAEGIHLAAMAGSIDL MAB_0578c|M.abscessus_ATCC_199 ATLYIGLSGLIDPTDPRFTATVIATEAELRSGATVYRYHRDDCLPGGEGG . . : : MLBr_00414|M.leprae_Br4923 -------------------------------------------------- MUL_0921|M.ulcerans_Agy99 -------------------------------------------------- MAV_4338|M.avium_104 -------------------------------------------------- Mb2029|M.bovis_AF2122/97 PQRCYSGLELRDDRLVLSPQWPEALGPLEFPFVYRRHQLSLRISGRSATL Rv2006|M.tuberculosis_H37Rv LQRCYSGLELRDDRLVLSPQWPEALGPLEFPFVYRRHQLSLRISGRSATL MMAR_2257|M.marinum_M VQRCFTGLEIRADRIVLSPHWPEYLGALGFPIHYRGNHLHLRVSGKGAEI TH_1155|M.thermoresistible__bu VQRCFTGLETRSDRIVLSPNWPESLGALGFPIRYRGHQMYVRVSGRGAEI Mvan_4107|M.vanbaalenii_PYR-1 MQRCFTGLETRSNRIILSPYWPESLGVLAIPIHYRGLHLHLRVSGKGVII MSMEG_3954|M.smegmatis_MC2_155 LQRCFTGLETRGDRLVLGPCWPEALGVLSFRMYYRGHNLHLRVSGRTASV Mflv_4989|M.gilvum_PYR-GCK LQRCFTGLELRRDRIVVGPMWPEPLGRLAFTFRYRGHRLRLTVLGRSSTL MAB_0578c|M.abscessus_ATCC_199 FHLCAAWLVEAYLLIGARSQAELLFDQLVKATGPTGLLSEEYDPVAERSL MLBr_00414|M.leprae_Br4923 --------------------------------- MUL_0921|M.ulcerans_Agy99 --------------------------------- MAV_4338|M.avium_104 --------------------------------- Mb2029|M.bovis_AF2122/97 TAESGDAEPIEVECRGHVQRLRCGHTIEVGCSR Rv2006|M.tuberculosis_H37Rv TAESGDAEPIEVECRGHVQRLRCGHTIEVGCSR MMAR_2257|M.marinum_M SVEPRDVPPVEVECHGRVERLLPGSTVRFS--- TH_1155|M.thermoresistible__bu SVAPRDLPPVAVECNGRVQRLEPGTTVRFT--- Mvan_4107|M.vanbaalenii_PYR-1 SVDPRDAAGIEVECRGQVVQLMPGTTVRFPG-- MSMEG_3954|M.smegmatis_MC2_155 ISAIGSAAPITLECRGRTWQLCAGTTIDVG--- Mflv_4989|M.gilvum_PYR-GCK SAEPSEASPILVECRGQAQTLVAGGTVEFTR-- MAB_0578c|M.abscessus_ATCC_199 GNHPQAYSHIGLLRCAALLS-------------