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SETFCLTDHSEPMTARFLSVVLRRIRGMRSDTREEISAALDAYHASLSRVLDLKCDALTTPELLACLQRL EVERRRQGAAEHALINQLAGQACEEELGGTLRTALANRLHITPGEASRRIAEAEDLGERRALTGEPLPAQ LTATAAAQREGKIGREHIKEIQAFFKELSAAVDLGIREAAEAQLAELATSRRPDHLHGLATQLMDWLHPD GNFSDQERARKRGITMGKQEFDGMSRISGLLTPELRATIEAVLAKLAAPGACNPDDQTPLVDDTPDADAV RRDTRSQAQRNHDAFLAALRGLLASGELGQHKGLPVTIVVSTTLKELEAATGKGVTGGGSRVPMSDLIRM ASHANHYLALFDGAKPLALYHTKRLASPAQRIMLYAKDRGCSRPGCDAPAYHSEVHHVTPWTTTHRTDIN DLTLACGPDNRLVEKGWKTRKNAHGDTEWLPPPHLDHGQPRINRYHHPAKILCEQDDDEPH*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv1148c | - | - | 100% (482) | hypothetical protein Rv1148c |
| M. tuberculosis H37Rv | Rv1945 | - | 0.0 | 97.14% (454) | hypothetical protein Rv1945 |
| M. tuberculosis H37Rv | Rv1128c | - | e-165 | 63.31% (447) | hypothetical protein Rv1128c |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1179c | - | 0.0 | 100.00% (482) | hypothetical protein Mb1179c |
| M. gilvum PYR-GCK | Mflv_4397 | - | 1e-104 | 46.46% (452) | hypothetical protein Mflv_4397 |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0394c | - | 1e-124 | 51.61% (436) | hypothetical protein MAB_0394c |
| M. marinum M | MMAR_1523 | - | 1e-161 | 61.95% (452) | hypothetical protein MMAR_1523 |
| M. avium 104 | MAV_2352 | - | 1e-159 | 61.95% (452) | hypothetical protein MAV_2352 |
| M. smegmatis MC2 155 | MSMEG_2663 | - | 2e-84 | 40.40% (448) | hypothetical protein MSMEG_2663 |
| M. thermoresistible (build 8) | TH_3287 | - | 2e-73 | 37.47% (483) | PUTATIVE conserved hypothetical protein |
| M. ulcerans Agy99 | MUL_2371 | - | 1e-161 | 60.98% (451) | hypothetical protein MUL_2371 |
| M. vanbaalenii PYR-1 | Mvan_3050 | - | 1e-105 | 45.87% (484) | hypothetical protein Mvan_3050 |
CLUSTAL 2.0.9 multiple sequence alignment
Rv1148c|M.tuberculosis_H37Rv MSETFCLTDHSEPMTARFLSVVLRRIRGMRS---DTREEISAALDAYHAS
Mb1179c|M.bovis_AF2122/97 MSETFCLTDHSEPMTARFLSVVLRRIRGMRS---DTREEISAALDAYHAS
MMAR_1523|M.marinum_M ----------------------------MSS---MSREEVVAAFDALDAV
MUL_2371|M.ulcerans_Agy99 ----------------------------MHSNGCSDRESVVATLDRLDRA
MAV_2352|M.avium_104 ----------------------------MHS---STREEIRADVDALRAA
MAB_0394c|M.abscessus_ATCC_199 ----------------------------------------MSPIDDLLTT
TH_3287|M.thermoresistible__bu -------------------------MGQQFVTAGAARARVGELLAAVDAA
Mvan_3050|M.vanbaalenii_PYR-1 --------------------------------MGCSREDVLGAFDALDAV
Mflv_4397|M.gilvum_PYR-GCK ----------------------------------MSGGDLQTSIAALRAA
MSMEG_2663|M.smegmatis_MC2_155 ---------------------------MIRTSVRYMAAEVGTALAALHAA
.
Rv1148c|M.tuberculosis_H37Rv LSRVLDLKCDALTTPELLACLQRLEVERRRQGAAEHALINQLAGQACEEE
Mb1179c|M.bovis_AF2122/97 LSRVLDLKCDALTTPELLACLQRLEVERRRQGAAEHALINQLAGQACEEE
MMAR_1523|M.marinum_M MARLQDLCFDGLTTPERLALLQRCEVARRRLPSIEHPLINQLVEQAGEQE
MUL_2371|M.ulcerans_Agy99 VDALVEVSFEALTTPERLRVLERLEVVARRLPAAQYALVNQLDEQPGEAE
MAV_2352|M.avium_104 VSRVLGHSYDALTTPERLRLLEIFDRETRRLRVPGHQLINQLAEQSDPTE
MAB_0394c|M.abscessus_ATCC_199 ATAVVESSFDELNNPELLSALRQLEIAQRKITAASHTLTARLVQRGSPVA
TH_3287|M.thermoresistible__bu YAEMRALCLDEVGTGFRLELAERLETQCRINRGLMYRVFAQLADPPDEPA
Mvan_3050|M.vanbaalenii_PYR-1 VESILALDYDALSAAERVRLEARLERNLRRIPTVEHELLASVIAETEPAR
Mflv_4397|M.gilvum_PYR-GCK FEEVAAADVDLLTRPDLVAALDELEELSCQLPAVGHRLLARLQVETSARE
MSMEG_2663|M.smegmatis_MC2_155 MRDVLALPYTALSDADLLDVCAGIQDVRNLAPAVEHRAIAALSEQTTPAA
: : : : : :
Rv1148c|M.tuberculosis_H37Rv LGGT-LRTALANRLHITPGEASRRIAEAEDLGERRALTGEPLPAQLTATA
Mb1179c|M.bovis_AF2122/97 LGGT-LRTALANRLHITPGEASRRIAEAEDLGERRALTGEPLPAQLTATA
MMAR_1523|M.marinum_M LGGK-LAAVLAGRLRVSRGEASRRLREAADLGPRRALTGEQLAPLLSATA
MUL_2371|M.ulcerans_Agy99 LGGR-LAAVVASRLRITRSEAGRRVAEAAEVGPRRALSGQPVGPVLTATA
MAV_2352|M.avium_104 LGGR-LSFALAERLHITRSDASRRIAEAADLGPRRALTGEPLPPLLPATA
MAB_0394c|M.abscessus_ATCC_199 LGGTSFAEVLARYLSITTATARRRLADAAHLGPRRALTGEPLRPALPYVA
TH_3287|M.thermoresistible__bu MVPA-VRDRLWARLRITPGEVKRRLRVAALLRPRRRLSGPPLPPVLARVA
Mvan_3050|M.vanbaalenii_PYR-1 LGEGSWKKVLTTALRISGAEAGRRLKRAKTLGPRRGLTGTPLPPLWESTA
Mflv_4397|M.gilvum_PYR-GCK MGAKSWNQVLAVRWRISTGEAHRRLTEAALLAPRQSLTGTPLPPALPATA
MSMEG_2663|M.smegmatis_MC2_155 IGAKSWPLVLATRLGISSKEARRRCADAAELGPRVSLTGEALAPKREHIA
: : :: . ** * : * *:* : . *
Rv1148c|M.tuberculosis_H37Rv AAQREGKIGREHIKEIQAFFKELSAAVDLGIREAAEAQLAELATSRRPDH
Mb1179c|M.bovis_AF2122/97 AAQREGKIGREHIKEIQAFFKELSAAVDLGIREAAEAQLAELATSRRPDH
MMAR_1523|M.marinum_M SAVRQGRIGAGHVRVIREFCGQVPAEVDLETRERAEAHLARLAGQFRPDQ
MUL_2371|M.ulcerans_Agy99 AALRQGVVGEGHVRVIRDFFRQLPAGVDVGTRDRAEAHLAKLATQFRPDQ
MAV_2352|M.avium_104 AAQRDGAIGTDHVAVIRQFFDQLPEAVDVETCEHAERQLAAQATQFRPDQ
MAB_0394c|M.abscessus_ATCC_199 HALREGRLGDEHVRIIRRFFDVLPDAVDADTREAAEKQLASMGTEFGPEQ
TH_3287|M.thermoresistible__bu GAVESGLLGEEHLRVITTVMAALPSAVSVTDREAVEASLIAEAARSDAGI
Mvan_3050|M.vanbaalenii_PYR-1 AAQAQGLLSEEHVAVIAAFHKRLPAWVDIETRAEADRQLAHAGSGLDPEG
Mflv_4397|M.gilvum_PYR-GCK VAQSRGLINAEHVEVIRKAVKKLPGWVDVATREQFEVNLVRTAVGNGPKE
MSMEG_2663|M.smegmatis_MC2_155 AAQADGALTPDHVTELFKFFTKCPDWVTYAEQCRLEEKLVTGAIGADPET
* * : *: : . * : * . .
Rv1148c|M.tuberculosis_H37Rv LHGLATQLMDWLHPDG-NFSDQERARKRGITMGKQEFDGMSRISGLLTPE
Mb1179c|M.bovis_AF2122/97 LHGLATQLMDWLHPDG-NFSDQERARKRGITMGKQEFDGMSRISGLLTPE
MMAR_1523|M.marinum_M LAKLAQRLMDCVNPDG-RYSDEDRARRRGLTLGRQGRDGMSRISGWLTPE
MUL_2371|M.ulcerans_Agy99 LARLAGRLMDCLNPDG-RHSDEDRARRRGLSLGRQGLDGMSRISGWLTPE
MAV_2352|M.avium_104 LSKLARRLMDCLNPDG-RYSDEDRARARGLVLGNQQADGMSRLSGWLTPE
MAB_0394c|M.abscessus_ATCC_199 LRAGADRIAALVNPDG-RFSDIDRARRRGISIGRQGADGMSALSGLLDPE
TH_3287|M.thermoresistible__bu VRQVGRRIEEIFNPDG-HYDDQDRARRRGIHLGDQQRDGMSAISGWIDPQ
Mvan_3050|M.vanbaalenii_PYR-1 LDEAAGVLLAMINPDGAQPCDKERARKRGIRISKQHPDGTATISGTLTPE
Mflv_4397|M.gilvum_PYR-GCK LRDAAELTLFLLDQDGPEPDDTERARKRGLTKGKQRPDGMIDLAGTLTPE
MSMEG_2663|M.smegmatis_MC2_155 VRQAVDHAVFLLDQDGPAPTDNPPTKPFGITFGPQQPDGSYHLRGKVSAE
: .. ** * :: *: . * ** : * : .:
Rv1148c|M.tuberculosis_H37Rv LRATIEAVLAKLAAP--------------------GACNPDDQTP-----
Mb1179c|M.bovis_AF2122/97 LRATIEAVLAKLAAP--------------------GACNPDDQTP-----
MMAR_1523|M.marinum_M ARAGLDAVLAKLAAP--------------------GMCNPDDESP-----
MUL_2371|M.ulcerans_Agy99 ARAGLEAVWAKLAAP--------------------GMCNPEDEAA-----
MAV_2352|M.avium_104 ARAGWEAVLAKLAAP--------------------GMCNPDDDAP-----
MAB_0394c|M.abscessus_ATCC_199 TRAYFDAVLSKLAAP--------------------GMCDPRDESP-----
TH_3287|M.thermoresistible__bu LRAYLEAVTAAVRPGRHLPHTTTDTTGTTGTTETTGTAGTAGTAA-----
Mvan_3050|M.vanbaalenii_PYR-1 ALAIWQAIFAKEAAPG----ANNPESEHTEDSTSGGAADDASDAPGDHAG
Mflv_4397|M.gilvum_PYR-GCK AWAVLEVIFAKYAAP--------------------GMCNPADPEP-----
MSMEG_2663|M.smegmatis_MC2_155 FKATFDPIDEKLAAP--------------------GMCNPTDQTP-----
* : : . * .. . .
Rv1148c|M.tuberculosis_H37Rv --LVDDTPDADAVRRDT---------RSQAQRNHDAFLAALRGLLASGEL
Mb1179c|M.bovis_AF2122/97 --LVDDTPDADAVRRDT---------RSQAQRNHDAFLAALRGLLASGEL
MMAR_1523|M.marinum_M --VVQAPAGADAVSRDR---------RSVGQRHHDGLNAAVRALLASGDL
MUL_2371|M.ulcerans_Agy99 --VVDGPVSRDAADRDS---------RSVSQRQHDGFNAALRAVLASGEL
MAV_2352|M.avium_104 --VVDGPPPEAASQRDS---------RSAAQRNHDGLNAALRALLAGGKL
MAB_0394c|M.abscessus_ATCC_199 --MTEGEPDSAAAERDT---------RTSAQRNHDGLRACLRSTLASGKL
TH_3287|M.thermoresistible__bu --TAADTAADGVGDIDTGGVDL----RSAAQRRHDGLTLGLKIAVASGRL
Mvan_3050|M.vanbaalenii_PYR-1 AASSAASGASDAAEHDPQPERCGSDTRTQAQRNHDAFLAVGRRLLESGEL
Mflv_4397|M.gilvum_PYR-GCK --CTYGTPTQAQIDNDQ---------RSLAQRQHDALVAVGRIALMSGEL
MSMEG_2663|M.smegmatis_MC2_155 --CISGTPSQQQIDHDE---------RGAPERRHDAMLTAMRLLLAHKDL
* * :*.**.: : : *
Rv1148c|M.tuberculosis_H37Rv GQHKGLPVTIVVSTTLKELEAAT-----------GKGVTGGGSRVPMSDL
Mb1179c|M.bovis_AF2122/97 GQHKGLPVTIVVSTTLKELEAAT-----------GKGVTGGGSRVPMSDL
MMAR_1523|M.marinum_M GQHNGLPASIIVTTTLGELQRAC-----------GRGLTGGGTVLPISDV
MUL_2371|M.ulcerans_Agy99 GQHNGLPASIIVSTTLKELEAAA-----------GRGLTGGGTLLPMSDV
MAV_2352|M.avium_104 GQHNGLPASIIVTTTLRDLESAA-----------GKGLTGGGTLLPMSEV
MAB_0394c|M.abscessus_ATCC_199 GAHRGLPVTVVVSTTLRELQSAA-----------GRAISGSGNLVPIPDL
TH_3287|M.thermoresistible__bu GSHRGHPVTVIVRTTLGELNQAAHAVADPRVSMPGPARTGGTGVLPMREL
Mvan_3050|M.vanbaalenii_PYR-1 GTHNGLPVTVIVSTTLQELEKGA-----------GVAVTGGGSLLPMPDL
Mflv_4397|M.gilvum_PYR-GCK GQLNGLPVSIIIRTTLQDLESRA-----------GVGTTGGGTVVPIKDV
MSMEG_2663|M.smegmatis_MC2_155 GQINGLPATLLITTTLQELEKAA-----------GVAITAGGTKLSIPDL
* .* *.:::: *** :*: * . :.. :.: ::
Rv1148c|M.tuberculosis_H37Rv IRMASHANHYLALF--DGAKPLALYHTKRLASPAQRIMLYAKDRGCSRPG
Mb1179c|M.bovis_AF2122/97 IRMASHANHYLALF--DGAKPLALYHTKRLASPAQRIMLYAKDRGCSRPG
MMAR_1523|M.marinum_M IRLARHAHHYLAVF--DRGKAVGLYHAKRLATAGQRLVLYAKDRGCTRPG
MUL_2371|M.ulcerans_Agy99 IRLARHAHHYLAVF--DRGEAIGLYHAKRLATPGQRIVLYAKDRGCTRPG
MAV_2352|M.avium_104 IRLARHAHHYLAVF--DNGKPLALYHTKRLASPGQRIVLYAKDRGCSHPG
MAB_0394c|M.abscessus_ATCC_199 IRMATHAFHYLTIFG-DDGRPLHLGRSKRIATPDQRIVLHAKDRGCSAPG
TH_3287|M.thermoresistible__bu IRMAADAIHYLAVFDDHTERPLYLGRQKRIATADQRLICYARDGGCTAPG
Mvan_3050|M.vanbaalenii_PYR-1 IRLAARAHHYLYVYDQHSGKSLYLGRAKRLANAAQRIVLHARDRGCTRPG
Mflv_4397|M.gilvum_PYR-GCK IRMAGHANHYLAVFDRATGSALDLFRTRRVASPAQRVMLIARDGGCTKPC
MSMEG_2663|M.smegmatis_MC2_155 IRLASQALHYLAVYDEHTGVPLYLGRARRTASAGQRLAIWARDRGCTRPG
**:* * *** :: .: * : :* *.. **: *:* **: *
Rv1148c|M.tuberculosis_H37Rv CDAPAYHSEVHHVTP-WTTTHRTDINDLTLACGPDNR-LVEKG--WKTRK
Mb1179c|M.bovis_AF2122/97 CDAPAYHSEVHHVTP-WTTTHRTDINDLTLACGPDNR-LVEKG--WKTRK
MMAR_1523|M.marinum_M CDVPGYQCEVHHVAA-WATSGRTDIDQLTLACGPDHK-LLEQG--WRTRK
MUL_2371|M.ulcerans_Agy99 CDVAGYQCEVHHVAA-WAISGRTDINQLTLACGPDHK-LLEQG--WRTRK
MAV_2352|M.avium_104 CDVSGYYCEVHHVTG-YAKCGRTDIDQLTFACGGHHP-LAEQG--WITRK
MAB_0394c|M.abscessus_ATCC_199 CTVPGYLCQVHHVDD-WRDDGPTDIDNLTFACGPHHR-LLQQG--WTTRK
TH_3287|M.thermoresistible__bu CGEPGYHAETHHQPA-WEDGGLTDADHLFFACGPHHSGLTEGR--WQATI
Mvan_3050|M.vanbaalenii_PYR-1 CTAPGYWCQAHHASADFVDGGLTNIDDLTLACPCDHRMLDNTG--WRTRK
Mflv_4397|M.gilvum_PYR-GCK CTVGAYGCQVHHAETDYAHGGNTNIDELGLACGPDNRSVTEGG--WTTRI
MSMEG_2663|M.smegmatis_MC2_155 CTANGYRCQAHHATTDYAKGGLTDADALALACGCDNRLVGEAPNKWTTRI
* .* .:.** : *: : * :** .: : : * :
Rv1148c|M.tuberculosis_H37Rv N-AHGDTEWLPPPHLDHGQPRINRYHHPAKILCEQ-----DDDEPH----
Mb1179c|M.bovis_AF2122/97 N-AHGDTEWLPPPHLDHGQPRINRYHHPAKILCEQ-----DDDEPH----
MMAR_1523|M.marinum_M N-AHGDTEWLPPPHLDHGQPRTNTYHHPEKLLRDS-----AADEG-----
MUL_2371|M.ulcerans_Agy99 N-AHGDTEWLPPPHLDHGQPRTNSYHHPEKLLRDS-----ADDDD-----
MAV_2352|M.avium_104 N-GRGETEWIPPPHLERGQPRVNSFHHPEDMLCDT-----EDQQDQQDQQ
MAB_0394c|M.abscessus_ATCC_199 RRSDGITEWIPPPHLDTGQSRTNDHHHPERFIRRF---------------
TH_3287|M.thermoresistible__bu T-PTGRLAWTN----DHHPPTVNHAHHPEELLRAH-----TDPPEDPG--
Mvan_3050|M.vanbaalenii_PYR-1 N-GKNQTEWLPPPDLDTGQHRVNGHHHPERYLLPE-----DDLPEDDQGP
Mflv_4397|M.gilvum_PYR-GCK N-DRCEVEWIPPPGLDTGQARVNTYHRPERLLAPP------DDPEPPNQT
MSMEG_2663|M.smegmatis_MC2_155 N-NHGQCEWIPPQLLDRGQHRTNTYHHPETLLADIKSGFTDDTADSRSQT
* : * *:* :
Rv1148c|M.tuberculosis_H37Rv --------------------------------------------------
Mb1179c|M.bovis_AF2122/97 --------------------------------------------------
MMAR_1523|M.marinum_M ----EEGG------------------------------------------
MUL_2371|M.ulcerans_Agy99 ----EGHGAA----------------------------------------
MAV_2352|M.avium_104 DQADEEDGAA----------------------------------------
MAB_0394c|M.abscessus_ATCC_199 --------------------------------------------------
TH_3287|M.thermoresistible__bu --------------------------------------------------
Mvan_3050|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_4397|M.gilvum_PYR-GCK -RTTATEPVEDQAID-----------------------------DPETDA
MSMEG_2663|M.smegmatis_MC2_155 SKTTGSETHAKQAADTEPDTAIARGNDLSDRPAIPPELLGQNHQQPNTNH
Rv1148c|M.tuberculosis_H37Rv --------------------------------------------------
Mb1179c|M.bovis_AF2122/97 --------------------------------------------------
MMAR_1523|M.marinum_M --------------------------------------------------
MUL_2371|M.ulcerans_Agy99 --------------------------------------------------
MAV_2352|M.avium_104 --------------------------------------------------
MAB_0394c|M.abscessus_ATCC_199 --------------------------------------------------
TH_3287|M.thermoresistible__bu --------------------------------------------------
Mvan_3050|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_4397|M.gilvum_PYR-GCK PPPLD-----DPGEPG--------------GPAPPDNRAA----------
MSMEG_2663|M.smegmatis_MC2_155 HPDTERGDARNSGATGHNQDHSRKNGDRNSGDASKGNNGNADGDDGESDC
Rv1148c|M.tuberculosis_H37Rv ---
Mb1179c|M.bovis_AF2122/97 ---
MMAR_1523|M.marinum_M ---
MUL_2371|M.ulcerans_Agy99 ---
MAV_2352|M.avium_104 ---
MAB_0394c|M.abscessus_ATCC_199 ---
TH_3287|M.thermoresistible__bu ---
Mvan_3050|M.vanbaalenii_PYR-1 ---
Mflv_4397|M.gilvum_PYR-GCK ---
MSMEG_2663|M.smegmatis_MC2_155 HPA