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M. tuberculosis H37Rv Rv1681 (moeX)

annotation: POSSIBLE MOLYBDOPTERIN BIOSYNTHESIS PROTEIN MOEX
coordinates: 1905250 - 1906242
length: 330

VIIELMRRVVGLAQGATAEVAVYGDRDRDLAERWCANTGNTLVRADVDQTGVGTLVVRRGHPPDPASVLG
PDRLPGVRLWLYTNFHCNLCCDYCCVSSSPSTPHRELGAERIGRIVGEAARWGVRELFLTGGEPFLLPDI
DTIIATCVKQLPTTVLTNGMVFKGRGRRALESLPRGLALQISLDSATPELHDAHRGAGTWVKAVAGIRLA
LSLGFRVRVAATVASPAPGELTAFHDFLDGLGIAPGDQLVRPIALEGAASQGVALTRESLVPEVTVTADG
VYWHPVAATDERALVTRTVEPLTPALDMVSRLFAEQWTRAAEEAALFPCA

Operon Prediction Model: Genebank

Paralogs

species id gene e-value identity (len) annotation
M. tuberculosis H37Rv Rv1681 moeX - 100% (330) POSSIBLE MOLYBDOPTERIN BIOSYNTHESIS PROTEIN MOEX
M. tuberculosis H37Rv Rv0693 pqqE 1e-09 29.94% (157) coenzyme PQQ synthesis protein E
M. tuberculosis H37Rv Rv3109 moaA1 2e-07 29.29% (140) molybdenum cofactor biosynthesis protein A

Closest Orthologs (e-value cutoff: 1e-4)

species id gene e-value identity (len) annotation
M. bovis AF2122 / 97 Mb1708 moeX 0.0 100.00% (330) molybdopterin biosynthesis protein MoeX
M. gilvum PYR-GCK Mflv_5060 - 1e-09 28.57% (175) radical SAM domain-containing protein
M. leprae Br4923 - - - - -
M. abscessus ATCC 19977 MAB_3835c - 2e-10 32.61% (138) coenzyme PQQ synthesis protein E PqqE
M. marinum M MMAR_1021 pqqE 6e-11 30.10% (196) coenzyme PQQ synthesis protein E, PqqE
M. avium 104 MAV_4478 - 4e-10 30.63% (160) radical SAM domain-containing protein
M. smegmatis MC2 155 MSMEG_1423 - 2e-08 31.39% (137) radical SAM domain-containing protein
M. thermoresistible (build 8) TH_1901 pqqE 2e-11 30.29% (175) PROBABLE COENZYME PQQ SYNTHESIS PROTEIN E PQQE (COENZYME PQQ
M. ulcerans Agy99 MUL_0773 pqqE 4e-11 30.10% (196) coenzyme PQQ synthesis protein E, PqqE
M. vanbaalenii PYR-1 Mvan_5883 - 1e-134 67.98% (331) radical SAM domain-containing protein

CLUSTAL 2.0.9 multiple sequence alignment


MMAR_1021|M.marinum_M               ---------MTTA--VPRLIEQFEHGLDAPICLTWELTYACNLACVHCLS
MUL_0773|M.ulcerans_Agy99           ---------MTTA--VPRLIEQFEHGLDAPICLTWELTYACNLACVHCLS
MAV_4478|M.avium_104                ---------MTTAAPVPRLIEQFEHGLDAPICLTWELTYACNLACVHCLS
MSMEG_1423|M.smegmatis_MC2_155      ---------MTSVQPVPRLVEQFERGLDAPICLTWELTYACNLACVHCLS
TH_1901|M.thermoresistible__bu      ---------------VPRLIEQFEQGLDAPICLTWELTYACNLACVHCLS
Mflv_5060|M.gilvum_PYR-GCK          ---------MTLAAPVPRLVDQFERGLDAPICLTWELTYACNLSCVHCLS
MAB_3835c|M.abscessus_ATCC_199      MSAPAVPRLNVAAVAAPKLVDQFEQGLDAPICLTWELTYACNLSCVHCLS
Rv1681|M.tuberculosis_H37Rv         -----------MIIELMRRVVGLAQGATAEVAVYGDR-------------
Mb1708|M.bovis_AF2122/97            -----------MIIELMRRVVGLAQGATAEVAVYGDR-------------
Mvan_5883|M.vanbaalenii_PYR-1       ----------MVILDLMRLMATLADGAVGEIAVASVA-------------
                                                     : :  :  *  . :.:                 

MMAR_1021|M.marinum_M               SSGKRDPGELSTRQCQDIIDELERMQVFYVNIGGGEPTVRPDFWELVDYA
MUL_0773|M.ulcerans_Agy99           SSGKRDPGELSTRQCQDIIDELERMQVFYVNIGGGEPTVRPDFWELVDYA
MAV_4478|M.avium_104                SSGKRDPRELSTRQCMDIIDELERMQVFYVNIGGGEPTVRPDFWELVDYA
MSMEG_1423|M.smegmatis_MC2_155      SSGKRDPRELSTQQCKDIIDELERMQVFYVNIGGGEPTVRSDFWELVDYA
TH_1901|M.thermoresistible__bu      SSGKRDPRELSTQQCKDIIDELQRMQVFYVNIGGGEPTVRSDFWELVDYA
Mflv_5060|M.gilvum_PYR-GCK          SSGKRDPRELSTQQCKDIIDELERMQVFYVNIGGGEPTVRSDFWELVDYA
MAB_3835c|M.abscessus_ATCC_199      SSGKRDPRELSTQQCKDIIDELERMQVFYVNIGGGEPTVRSDFWELVDYA
Rv1681|M.tuberculosis_H37Rv         ------DRDLAERWCANTGNTLVRADVDQT--GVGTLVVR----------
Mb1708|M.bovis_AF2122/97            ------DRDLAERWCANTGNTLVRADVDQT--GVGTLVVR----------
Mvan_5883|M.vanbaalenii_PYR-1       ------ERETAEKWCARSGNTVVQADLDET--GAGTLTVR----------
                                            : : : *    : : : ::  .  * *  .**          

MMAR_1021|M.marinum_M               TAHHVGVKFSTNGVRINPEVAARLAASDYVDVQISLDGATAEVNDAVRGA
MUL_0773|M.ulcerans_Agy99           TAHHVGVKFSTNGVRINPEVAARLAASDCVDVQISLDGATAEVNDAVRGA
MAV_4478|M.avium_104                TAHHVGVKFSTNGVRITPEVAARLAASDYVDVQISLDGATAEVNDAVRGP
MSMEG_1423|M.smegmatis_MC2_155      TAHHVGVKFSTNGVRITPEVAAKLAASDYVDVQISLDGANAEVNDAVRGK
TH_1901|M.thermoresistible__bu      TAHNVGVKFSTNGVRITPEVARRLAASDYVDVQISLDGATAEINDAVRGA
Mflv_5060|M.gilvum_PYR-GCK          TEHHVGVKFSTNGVRIDKTVAAKLAASDYVDVQISLDGATAEVNDAVRGP
MAB_3835c|M.abscessus_ATCC_199      TEHHVGVKFSTNGVRITEEVAARLAASDYVDVQISLDGATAEVNDAVRGA
Rv1681|M.tuberculosis_H37Rv         -RGHPPDPASVLGPDRLPGVRLWLYTNFHCNLCCDYCCVSSSPSTPHREL
Mb1708|M.bovis_AF2122/97            -RGHPPDPASVLGPDRLPGVRLWLYTNFHCNLCCDYCCVSSSPSTPHREL
Mvan_5883|M.vanbaalenii_PYR-1       -RGRPPDPLLVLGPERMPGARLWMYTNFHCNLACDYCCVESSPQAPRREL
                                       .      . *      .   : :.   ::  .   . :. . . *  

MMAR_1021|M.marinum_M               GSFAMAVRALENLAAAGFAD---AKISVVVTRHNVGQLDDFAALADRYGA
MUL_0773|M.ulcerans_Agy99           GSFAMAVRALENLAAAGFAD---AKISVVVTRHNVGQLDDFAALADRYGA
MAV_4478|M.avium_104                GSFDMAVRALQNLADAGFTQNGGAKISVVVTRHNVGQLDEFAALASRYGA
MSMEG_1423|M.smegmatis_MC2_155      GSFDMAVRALENLSNAGFTD---AKISVVVTRQNVDQLDEFAALAARYGA
TH_1901|M.thermoresistible__bu      GSFDMAVRALQNLADAGFAD---AKISVVVTRHNVDQLDDFKALADRYGA
Mflv_5060|M.gilvum_PYR-GCK          GSFAMAVRALENLKEAGFKD---AKISVVVTRHNIDQLDDFKALADTYGA
MAB_3835c|M.abscessus_ATCC_199      GSFDMAVRALENLAAAGFKD---AKISVVVTRHNVDQLDEFASLAARYGA
Rv1681|M.tuberculosis_H37Rv         G-AERIGRIVGEAARWGVRE-------LFLTGGEPFLLPDIDTIIATCVK
Mb1708|M.bovis_AF2122/97            G-AERIGRIVGEAARWGVRE-------LFLTGGEPFLLPDIDTIIATCVK
Mvan_5883|M.vanbaalenii_PYR-1       G-ADRIARLAREAADWGVRE-------VFLTGGEPFLLSDIGTIVRSCAA
                                    *      *   :    *. :       :.:*  :   * :: ::      

MMAR_1021|M.marinum_M               TLRITRLRPSGRGADVWEELHPTAAQQVALYDWLVAKGERVLTGDSFFHL
MUL_0773|M.ulcerans_Agy99           TLRITRLRPSGRGADVWEELHPTAAQQVALYDWLVAKGERVLTGDSFFHL
MAV_4478|M.avium_104                TLRITRLRPSGRGADVWDELHPTADQQVQLYDWLVAKGERVLTGDSFFHL
MSMEG_1423|M.smegmatis_MC2_155      TLRITRLRPSGRGADVWDDLHPTAEQQRQLYDWLVAKGDRVLTGDSFFHL
TH_1901|M.thermoresistible__bu      TLRITRLRPSGRGADVWDELHPTAEQQVQLYNWLVAHGEKVLTGDSFFHL
Mflv_5060|M.gilvum_PYR-GCK          TLRITRLRPSGRGADVWDDLHPTADQQVQLYNWLVAHGERVLTGDSFFHL
MAB_3835c|M.abscessus_ATCC_199      TLRITRLRPSGRGADVWDELHPTAAQQRQLYDWLVRNGERVLTGDSFFHL
Rv1681|M.tuberculosis_H37Rv         QLPTTVLTNG----MVFKGRGRRALESLPRG-LALQISLDSATPELHDAH
Mb1708|M.bovis_AF2122/97            QLPTTVLTNG----MVFKGRGRRALESLPRG-LALQISLDSATPELHDAH
Mvan_5883|M.vanbaalenii_PYR-1       LLPTTVLTNG----MVFRGRGLRELDAIPRDNVALQISLDSATSELHDSH
                                     *  * *  .     *:        :        :  .    * : .   

MMAR_1021|M.marinum_M               APLGS-SGALAGLNMCG-AGRVVCLIDPVGDVYACPFAIHDRFLAGNVLT
MUL_0773|M.ulcerans_Agy99           APLGS-SGALAGLNMCG-AGRVVCLIDPVGDVYACPFAIHDRFLAGNVLT
MAV_4478|M.avium_104                APLGQ-SGALAGLNMCG-AGRVVCLIDPVGDVYACPFAIHDRFLAGNVLS
MSMEG_1423|M.smegmatis_MC2_155      SGLGA-PGALAGLNLCG-AGRVVCLIDPVGDVYACPFAIHDKFLAGNILS
TH_1901|M.thermoresistible__bu      SGLGE-PGALAGLNLCG-AGRVVCLIDPVGDVYACPFAIHDRFLAGNVLT
Mflv_5060|M.gilvum_PYR-GCK          SGLGE-PGALAGLNLCG-AGRVVCLIDPVGDVYACPFAIHDKFLAGNILT
MAB_3835c|M.abscessus_ATCC_199      SAYGDGSGGLPGLNMCG-AGRVVCLIDPVGDVYACPFAIHDRFLAGNVLS
Rv1681|M.tuberculosis_H37Rv         RGAGTWVKAVAGIRLALSLGFRVRVAATVASPAPGELTAFHDFLDGLGIA
Mb1708|M.bovis_AF2122/97            RGAGTWVKAVAGIRLALSLGFRVRVAATVASPAPGELTAFHDFLDGLGIA
Mvan_5883|M.vanbaalenii_PYR-1       RGHGSWARAVEGIRVARGLGFRVRVAATVAAPVPGELKAFHDFLDELGIA
                                       *    .: *:.:.   *  * :  .*.   .  :  .. **    ::

MMAR_1021|M.marinum_M               DGGFDQVWKNAPLFRQLREPQSAGACGSCGHYDSCRGGCMAAKFFTGLPL
MUL_0773|M.ulcerans_Agy99           DGGFDQVWKNAPLFRQLREPQSAGACGSCGHYDSCRGGCMAAKFFTGLPL
MAV_4478|M.avium_104                DGGFDNVWKNAPLFRELREPQSAGACGSCGHYDSCRGGCMAAKFFTGLPL
MSMEG_1423|M.smegmatis_MC2_155      DGGFQNVWQHSELFRELREPQSAGACASCGHFDACRGGCMAAKFFTGLPL
TH_1901|M.thermoresistible__bu      DGGFDNVWKNSQLFRELREPQSAGACSGCSHFDSCRGGCMAAKFFTGLPL
Mflv_5060|M.gilvum_PYR-GCK          SNGFEDVWQNSELFRELREPQSAGACSGCNHYDACRGGCMAAKFFTGLPM
MAB_3835c|M.abscessus_ATCC_199      DNGFDQVWKHSQLFSELREPQSAGACGSCGHYDSCRGGCMAAKFFTGLPM
Rv1681|M.tuberculosis_H37Rv         PG--------DQLVRPIALEGAASQGVALTRESLVPEVTVTADGVYWHPV
Mb1708|M.bovis_AF2122/97            PG--------DQLVRPIALEGAASQGVALTRESLVPEVTVTADGVYWHPV
Mvan_5883|M.vanbaalenii_PYR-1       QD--------DQVVRPVAREGSAADGVQITRASLVPEVAVTAEGVYWHPV
                                     .          :.  :    :*.      : .      ::*. .   *:

MMAR_1021|M.marinum_M               DGPDPECVQGYGAPALAQERHAPRPRVDHSRGSR----VSAPVPLTLTTR
MUL_0773|M.ulcerans_Agy99           DGPDPECVQGYGAPALAQERHAPRPRVDHSRGSR----E-----------
MAV_4478|M.avium_104                DGPDPECVQGHSAAALAGDREAPRPRADHSRGKR----IRQPVPLTLSVR
MSMEG_1423|M.smegmatis_MC2_155      DGPDPECVEGWGAPALEKERVKPKPSGDHSRGT-----KQGPVALKLLTK
TH_1901|M.thermoresistible__bu      DGPDPECVEGHGAPALARERTKPKPRVDHSRG--------GPVALKLLTK
Mflv_5060|M.gilvum_PYR-GCK          DGPDPECVQGYGEPALAADRDKPKSSVDHSRSGG-RGKPKGPIPLTLLSA
MAB_3835c|M.abscessus_ATCC_199      DGPDPECVQGYGEAALAADRVVPKPSGDHSHSKSKRGPATGPVALTLTRR
Rv1681|M.tuberculosis_H37Rv         AATDERALVTRTVEPLTPALDMVSRLFAEQWTRA-----AEEAALFPCA-
Mb1708|M.bovis_AF2122/97            AATDERALVTRTVEPLTPALDMVSRLFAEQWTRA-----AEEAALFPCA-
Mvan_5883|M.vanbaalenii_PYR-1       AAIDDDALVTRQIEPLAPALDEIAHAFAELWARK-----ANAAQLFPCA-
                                     . *  .:      .*            .                     

MMAR_1021|M.marinum_M               --------PPARLCNESPV-------
MUL_0773|M.ulcerans_Agy99           --------------------------
MAV_4478|M.avium_104                PPVLTPAAPPARLCNESPV-------
MSMEG_1423|M.smegmatis_MC2_155      --------PPARFCNESPV-------
TH_1901|M.thermoresistible__bu      --------PPARLCNESPV-------
Mflv_5060|M.gilvum_PYR-GCK          --------PPKKFCNESPV-------
MAB_3835c|M.abscessus_ATCC_199      --------PPSRACDENPLSTLRAGR
Rv1681|M.tuberculosis_H37Rv         --------------------------
Mb1708|M.bovis_AF2122/97            --------------------------
Mvan_5883|M.vanbaalenii_PYR-1       --------------------------

species	id	gene	e-value	identity (len)	annotation
M. tuberculosis H37Rv	Rv1681	moeX	-	100% (330)	POSSIBLE MOLYBDOPTERIN BIOSYNTHESIS PROTEIN MOEX
M. tuberculosis H37Rv	Rv0693	pqqE	1e-09	29.94% (157)	coenzyme PQQ synthesis protein E
M. tuberculosis H37Rv	Rv3109	moaA1	2e-07	29.29% (140)	molybdenum cofactor biosynthesis protein A