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M. tuberculosis H37Rv Rv3109 (moaA1)

annotation: PROBABLE MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN A MOAA1
coordinates: 3477649 - 3478728
length: 359

MSTPTLPDMVAPSPRVRVKDRCRRMMGDLRLSVIDQCNLRCRYCMPEEHYTWLPRQDLLSVKEISAIVDV
FLSVGVSKVRITGGEPLIRPDLPEIVRTLSAKVGEDSGLRDLAITTNGVLLADRVDGLKAAGMKRITVSL
DTLQPERFKAISQRNSHDKVIAGIKAVAAAGFTDTKIDTTVMRGANHDELADLIEFARTVNAEVRFIEYM
DVGGATHWAWEKVFTKANMLESLEKRYGRIEPLPKHDTAPANRYALPDGTTFGIIASTTEPFCATCDRSR
LTADGLWLHCLYAISGINLREPLRAGATHDDLVETVTTGWRRRTDRGAEQRLAQRERGVFLPLSTLKADP
HLEMHTRGG

Operon Prediction Model: Genebank

Paralogs

species id gene e-value identity (len) annotation
M. tuberculosis H37Rv Rv3109 moaA1 - 100% (359) PROBABLE MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN A MOAA1
M. tuberculosis H37Rv Rv0869c moaA 7e-49 36.57% (309) molybdenum cofactor biosynthesis protein A
M. tuberculosis H37Rv Rv0693 pqqE 1e-10 30.32% (188) coenzyme PQQ synthesis protein E

Closest Orthologs (e-value cutoff: 1e-4)

species id gene e-value identity (len) annotation
M. bovis AF2122 / 97 Mb3136 moaA1 0.0 99.72% (359) molybdenum cofactor biosynthesis protein A
M. gilvum PYR-GCK Mflv_1705 moaA 9e-52 35.47% (327) molybdenum cofactor biosynthesis protein A
M. leprae Br4923 - - - - -
M. abscessus ATCC 19977 MAB_0871c moaA 9e-51 37.83% (304) molybdenum cofactor biosynthesis protein A
M. marinum M MMAR_4663 moaA 1e-47 35.60% (309) molybdenum cofactor biosynthesis protein A2 MoaA2
M. avium 104 MAV_4478 - 1e-09 30.85% (188) radical SAM domain-containing protein
M. smegmatis MC2 155 MSMEG_5698 moaA 2e-47 35.06% (308) molybdenum cofactor biosynthesis protein A
M. thermoresistible (build 8) TH_1071 moaA 5e-52 37.15% (323) molybdenum cofactor biosynthesis protein A
M. ulcerans Agy99 MUL_0281 moaA 2e-47 35.02% (317) molybdenum cofactor biosynthesis protein A
M. vanbaalenii PYR-1 Mvan_5047 moaA 8e-51 37.26% (314) molybdenum cofactor biosynthesis protein A

CLUSTAL 2.0.9 multiple sequence alignment


Rv3109|M.tuberculosis_H37Rv         --MSTPTLPDMVAPS-----------PRVRVKDRCRRMMGDLRLSVIDQC
Mb3136|M.bovis_AF2122/97            --MSTPTLPDMVAPS-----------PRVRVKDRCRRMMGDLRLSVIDQC
MMAR_4663|M.marinum_M               MTVTALGVPTVRGRS-EGSAIASDAPGDGPLLDRFGRSATDLRVSLTDRC
MUL_0281|M.ulcerans_Agy99           MTVTALGVPTVRGRS-EGSAVASDAPGDGPLLDRFGRSATDLRVSLTDRC
MSMEG_5698|M.smegmatis_MC2_155      MTVTALGLPTVARSTGDGSAGASPAPADGPLVDTYGRAATDLRVSLTDRC
TH_1071|M.thermoresistible__bu      MTVTALGLPAVRRPS-----PPSAPPASGPLVDTFGRVHTDLRISLTDRC
Mflv_1705|M.gilvum_PYR-GCK          MTVVPLGLPSVQRPS-------TPAPATGPLIDTFGRVATDLRVSLTDLC
Mvan_5047|M.vanbaalenii_PYR-1       MTVVALGVPSVHRPQ-------SPAPEEGPLVDTFGRVATDLRVSLTDLC
MAB_0871c|M.abscessus_ATCC_199      ---------------------------MTPLIDSFGRIATDLRVSLTDRC
MAV_4478|M.avium_104                -MTTAAPVPRLIEQF-----------------EHGLDAPICLTWELTYAC
                                                                    :        *  .:   *

Rv3109|M.tuberculosis_H37Rv         NLRCRYCMPEEHYTWLPRQDLLSVKEISAIVDVFLS-VGVSKVRITGGEP
Mb3136|M.bovis_AF2122/97            NLRCRYCMPEEHYTWLPRQDLLSVKEISAIVDVFLS-VGVSKVRITGGEP
MMAR_4663|M.marinum_M               NLRCGYCMPAEGLNWLPGEQLLGPAELARLLRIAVTRLGITSVRFTGGEP
MUL_0281|M.ulcerans_Agy99           NLRCGYCMPAEGLNWLPGEQLLGPAELARLPRIAVTPLGITSVRFTGGEP
MSMEG_5698|M.smegmatis_MC2_155      NLRCTYCMPAEGLNWLPGDALLSPTELARLLRIAVARLGITSVRFTGGEP
TH_1071|M.thermoresistible__bu      NLRCTYCMPAEGLDWLPGEHLLRPDELARLLHIAVTRLGITNVRFTGGEP
Mflv_1705|M.gilvum_PYR-GCK          NLRCTYCMPAEGLDWMPRDQKLTPDELTRLLRIGVTRLGITSIRFTGGEP
Mvan_5047|M.vanbaalenii_PYR-1       NLRCTYCMPAEGLDWLPSDEKLNPDELIRLLGVAVTRLGITSVRFTGGEP
MAB_0871c|M.abscessus_ATCC_199      NLRCTYCMPAEGLDWLRSETLLTTDEYIRLIGIAVTRLGIDSVRFTGGEP
MAV_4478|M.avium_104                NLACVHCLSSSGK---RDPRELSTRQCMDIID-ELERMQVFYVNIGGGEP
                                    ** * :*:. .          *   :   :    :  : :  :.: ****

Rv3109|M.tuberculosis_H37Rv         LIRPDLPEIVRTLSAKVGEDSGLRDLAITTNGVLLADRVDG-LKAAGMKR
Mb3136|M.bovis_AF2122/97            LIRPDLPEIVRTLSAKVGEDSGLRDLAITTNGVLLADRVDG-LKAAGMKR
MMAR_4663|M.marinum_M               LLARHLEEVVAAAAQLRPRP----EISLTTNGVGLAKRAAA-LAEAGLDR
MUL_0281|M.ulcerans_Agy99           LLARHLEEVVAAAAQLRPRP----EISLTTNGVGLAKRAAA-LAEAGLDR
MSMEG_5698|M.smegmatis_MC2_155      LVVRHLEEVVAAAAALEPRP----EITLTTNGLGLARRAEG-LKKAGLNR
TH_1071|M.thermoresistible__bu      LVARHLEEVVAAAAAERPRP----EIALTTNGIGLAKRARR-LKDAGLDR
Mflv_1705|M.gilvum_PYR-GCK          LVVPHLEDVLAATTALQPRP----EITLTTNGIGLAQRAAG-LRRAGLNR
Mvan_5047|M.vanbaalenii_PYR-1       LVVPHLEDVVAATAALRPRP----EITLTTNGVGLAKRAAG-LKRAGLDR
MAB_0871c|M.abscessus_ATCC_199      LIFKDLEKLVAAVAGMSPRP----DIAVTTNGVGLDRKAVA-LREAGLDR
MAV_4478|M.avium_104                TVRPDFWELVDYATAHHVGV------KFSTNGVRITPEVAARLAASDYVD
                                     :  .: .::   :             .:***: :  ..   *  :.   

Rv3109|M.tuberculosis_H37Rv         ITVSLDTLQPERFKAISQRNSHDKVIAGIKAVAAAGFTD---TKIDTTVM
Mb3136|M.bovis_AF2122/97            ITVSLDTLQPERFKAISQRNSHDKVIAGIKAVAAAGFTD---TKIDTTVM
MMAR_4663|M.marinum_M               VNVSLDTVDRAHFAAITRRDRLTDVLDGLAGARAAGLTP---VKVNAVLD
MUL_0281|M.ulcerans_Agy99           VNVSLDTVDRAHFAAVTRRDRLTDVLDGLAGARAAGLTP---VKVNAVLD
MSMEG_5698|M.smegmatis_MC2_155      INVSLDSVDAAHFARITRRDRLPDVLAGLAAAKAAGLEP---VKVNAVLD
TH_1071|M.thermoresistible__bu      VNVSLDTVDPVRFARITRRDRLADVLAGLEAARAAGLTP---VKVNAVLD
Mflv_1705|M.gilvum_PYR-GCK          INVSLDTVDPARFAAITRRDRFDDVIAGLHAAKEAGLQP---VKVNAVLD
Mvan_5047|M.vanbaalenii_PYR-1       INVSLDTVDPARFAAITRRDRFTEVVAGLRAAKEAGLDP---VKVNAVLD
MAB_0871c|M.abscessus_ATCC_199      INVSLDTLDAHRFAAITRRDRLSDVLLGLKAAGSAGLSP---IKINAVLT
MAV_4478|M.avium_104                VQISLDGATAEVNDAVRGPGSFDMAVRALQNLADAGFTQNGGAKISVVVT
                                    : :***         :   .    .: .:     **:      *:...: 

Rv3109|M.tuberculosis_H37Rv         RGANHDELADLIEFARTVNAEVRFIEYMDVG-GATHWAWEK---------
Mb3136|M.bovis_AF2122/97            RGANHDELADLIEFARTVNAEVRFIEYMDVG-GATHWAWEK---------
MMAR_4663|M.marinum_M               PETGRQDVVELLRFCLEQGYQLRVIEQMPLD-AGHQWRRNA---------
MUL_0281|M.ulcerans_Agy99           PETGRQDVVELLRFCLEQGYQLRVIEQMPLD-AGHQWRRNA---------
MSMEG_5698|M.smegmatis_MC2_155      PVSGLDDAVELLRYCLQHGYQLRIIEQMPLD-ASHSWQRDN---------
TH_1071|M.thermoresistible__bu      AETGLDDAVQLLRFCLDRGYQLRIIEQMPLD-AGHQWRRDQ---------
Mflv_1705|M.gilvum_PYR-GCK          PVTGLQDAVALLGFCLENGYQLRIIEQMPLD-AGHSWQRDR---------
Mvan_5047|M.vanbaalenii_PYR-1       PVSGLDDVVSLLRFCLEHGYQLRVIEQMPLD-AGHSWERER---------
MAB_0871c|M.abscessus_ATCC_199      PEQYKEDAVALLHFSLEHGYELRIIEQMPLD-AGHSWSRAR---------
MAV_4478|M.avium_104                RHN-VGQLDEFAALASRYGATLRITRLRPSGRGADVWDELHPTADQQVQL
                                          :   :   .   .  :*. .    . ..  *             

Rv3109|M.tuberculosis_H37Rv         ---VFTKANMLESLEKRYGRIEP--------------------LPKHDTA
Mb3136|M.bovis_AF2122/97            ---VFTKANMLESLEKRYGRIEP--------------------LPKHDTA
MMAR_4663|M.marinum_M               ---LLGSDDVLAALQPHFRLRPD--------------------PAPRGSA
MUL_0281|M.ulcerans_Agy99           ---LLGSDDVLAALQPHFRLRPD--------------------PAPRGSA
MSMEG_5698|M.smegmatis_MC2_155      ---VIDADRILQTLQQHFELTPD--------------------SRPRGSA
TH_1071|M.thermoresistible__bu      ---TLSADEVLAALQREFRLSPD--------------------PTPRGSA
Mflv_1705|M.gilvum_PYR-GCK          ---ALSADDILDTLRRHFTLTPD--------------------PAPRGSA
Mvan_5047|M.vanbaalenii_PYR-1       ---ALSADVILSALRRHFTLTPD--------------------PRPRGSA
MAB_0871c|M.abscessus_ATCC_199      ---MVTADEIHAALSREFSLSED--------------------PAPRGSA
MAV_4478|M.avium_104                YDWLVAKGERVLTGDSFFHLAPLGQSGALAGLNMCGAGRVVCLIDPVGDV
                                        .       :    :                             . .

Rv3109|M.tuberculosis_H37Rv         PANRYALPDG--------------------TTFGIIASTTEPFCATCDRS
Mb3136|M.bovis_AF2122/97            PANRYALPDG--------------------TTFGIIASTTEPFCATCDRS
MMAR_4663|M.marinum_M               PAELWLVDAGPDT---------------PAGKFGVIASVSHAFCSTCDRT
MUL_0281|M.ulcerans_Agy99           PAELWLVDAGPDT---------------PAGKFGVIASVSHAFCSTCDRT
MSMEG_5698|M.smegmatis_MC2_155      PAELWQVAEGPTH---------------AAGTVGVIASVSHAFCSACDRT
TH_1071|M.thermoresistible__bu      PAQLWRIDG-------------------TGATVGIIATVSHAFCSACDRT
Mflv_1705|M.gilvum_PYR-GCK          PAQLWRVHDG-TG---------------VVGRVGIIASVSHAFCSTCDRS
Mvan_5047|M.vanbaalenii_PYR-1       PAQLWQVHDD-GH---------------VTGHIGIIASVSDAFCSTCDRS
MAB_0871c|M.abscessus_ATCC_199      PAQRWLVNGG-------------------PATVGIIASVSRPFCGDCDRT
MAV_4478|M.avium_104                YACPFAIHDRFLAGNVLSDGGFDNVWKNAPLFRELREPQSAGACGSCGHY
                                     *  : :                           :  . :   *. *.: 

Rv3109|M.tuberculosis_H37Rv         RLTADGLWLHCLYAISGINLREPLRAGATHDDLVETVTTGWRRRTD---R
Mb3136|M.bovis_AF2122/97            RLTADGLWLHCLYAISGINLREPLRAGATHDDLVETVTTGWRRRAD---R
MMAR_4663|M.marinum_M               RLTADGQVRSCLFSTEETDLRGLLRAGAGDEAIEAAWRSAMWAKPA---G
MUL_0281|M.ulcerans_Agy99           RLTADGQVRSCLFSTEETDLRGLLRAGAGDEAIEAAWRGAMWAKPA---G
MSMEG_5698|M.smegmatis_MC2_155      RLTADGQIRSCLFSREETDLRHLLRGGADDAEIEAAWRAAMWSKPA---G
TH_1071|M.thermoresistible__bu      RLTADGQVRNCLFAQQETDLRGLLRSGADDDAVEAAWRAAMWAKAA---G
Mflv_1705|M.gilvum_PYR-GCK          RLTADGQVRNCLFARDETDLRALLRSGADDDVLEAAWRAAMWAKAA---G
Mvan_5047|M.vanbaalenii_PYR-1       RLTADGQVRNCLFARDETDLRALLRSGADDAALEDAWRAAMWAKAA---G
MAB_0871c|M.abscessus_ATCC_199      RLTADGQVRNCLFATTETDLRGLLRSGASDAEVASAWQAAMWGKKP---G
MAV_4478|M.avium_104                DSCRGGCMAAKFFTGLPLDGPDPECVQGHSAAALAGDREAPRPRADHSRG
                                        .*     :::    :        .           .   :      

Rv3109|M.tuberculosis_H37Rv         GAEQRLAQRERGVFLPLSTLKADPHLEMHTRGG
Mb3136|M.bovis_AF2122/97            GAEQRLAQRERGVFLPLSTLKADPHLEMHTRGG
MMAR_4663|M.marinum_M               HGINNPDFVQ-------------PQRPMSAIGG
MUL_0281|M.ulcerans_Agy99           HGINNPDFLQ-------------PQRPMSAIGG
MSMEG_5698|M.smegmatis_MC2_155      HGINDPDFVQ-------------PVRPMSAIGG
TH_1071|M.thermoresistible__bu      HGINDPDFVQ-------------PARPMSAIGG
Mflv_1705|M.gilvum_PYR-GCK          HGINDPDFVQ-------------PDRPMSAIGG
Mvan_5047|M.vanbaalenii_PYR-1       HGINDPGFVQ-------------PDRPMSAIGG
MAB_0871c|M.abscessus_ATCC_199      HGINDPSFLQ-------------PDRPMSAIGG
MAV_4478|M.avium_104                KRIRQPVPLTLSVRPPVLTPAAPPARLCNESPV
                                       .                   *

species	id	gene	e-value	identity (len)	annotation
M. tuberculosis H37Rv	Rv3109	moaA1	-	100% (359)	PROBABLE MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN A MOAA1
M. tuberculosis H37Rv	Rv0869c	moaA	7e-49	36.57% (309)	molybdenum cofactor biosynthesis protein A
M. tuberculosis H37Rv	Rv0693	pqqE	1e-10	30.32% (188)	coenzyme PQQ synthesis protein E