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VTETASETGSWRELLSRYLGTSIVLAGGVALYATNEFLTISLLPSTIADIGGSRLYAWVTTLYLVGSVVA ATTVNTMLLRVGARSSYLMGLAVFGLASLVCAAAPSMQILVAGRTLQGIAGGLLAGLGYALINSTLPKSL WTRGSALVSAMWGVATLIGPATGGLFAQLGLWRWAFGVMTLLTALMAMLVPVALGAGGVGPGGETPVGST HKVPVWSLLLMGAAALAISVAALPNYLVQTAGLLAAAALLVAVFVVVDWRIHAAVLPPSVFGSGPLKWIY LTMSVQMIAAMVDTYVPLFGQRLGHLTPVAAGFLGAALAVGWTVGEVASASLNSARVIGHVVAAAPLVMA SGLALGAVTQRADAPVGIIALWALALLIIGTGIGIAWPHLTVRAMDSVADPAESSAAAAAINVVQLISGA FGAGLAGVVVNTAKGGEVAAARGLYMAFTVLAAAGVIASYQATHRDRRLPR
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. tuberculosis H37Rv | Rv1634 | - | - | 100% (471) | Possible drug efflux membrane protein |
M. tuberculosis H37Rv | Rv1877 | - | 2e-29 | 24.52% (420) | integral membrane protein |
M. tuberculosis H37Rv | Rv0783c | emrB | 1e-20 | 23.44% (418) | multidrug resistance integral membrane efflux protein EmrB |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb1660 | - | 0.0 | 99.79% (471) | drug efflux membrane protein |
M. gilvum PYR-GCK | Mflv_3321 | - | 2e-32 | 27.29% (436) | EmrB/QacA family drug resistance transporter |
M. leprae Br4923 | MLBr_00556 | - | 3e-15 | 24.90% (482) | putative integral membrane drug transport protein |
M. abscessus ATCC 19977 | MAB_2310 | - | 1e-132 | 54.87% (452) | drug efflux membrane protein |
M. marinum M | MMAR_2438 | - | 0.0 | 80.64% (470) | drug efflux membrane protein |
M. avium 104 | MAV_3140 | - | 0.0 | 71.00% (469) | drug efflux membrane protein |
M. smegmatis MC2 155 | MSMEG_3815 | - | 1e-164 | 64.52% (465) | drug efflux membrane protein |
M. thermoresistible (build 8) | TH_2729 | - | 2e-24 | 24.72% (445) | PUTATIVE putative drug resistance transporter, EmrB/QacA |
M. ulcerans Agy99 | MUL_1617 | - | 0.0 | 79.57% (470) | drug efflux membrane protein |
M. vanbaalenii PYR-1 | Mvan_3349 | - | 1e-166 | 65.28% (458) | major facilitator superfamily transporter |
CLUSTAL 2.0.9 multiple sequence alignment Rv1634|M.tuberculosis_H37Rv MTETAS-----ETGSWRELLSR-YLGTSIVLAGGVALYATNEFLTISLLP Mb1660|M.bovis_AF2122/97 MTETAS-----ETGSWRELLSR-YLGTSIVLAGGVALYATNEFLTISLLP MMAR_2438|M.marinum_M MTETAR-----ETGSWRELLSG-HLGTATLLAGGVAMYATNEFLTVSLLP MUL_1617|M.ulcerans_Agy99 MTETAR-----ETGSWRELLRG-HLGTATLLAGGVAMYATNEFLTVSLLP MAV_3140|M.avium_104 MTDAAT-----ITGGWRELLGARYLRTSILLAGGVALYATNEFLTTSLLP MSMEG_3815|M.smegmatis_MC2_155 MTETAA---AEAAGTWRQLLGRRYLGASTVLAGGVLLYATNEFITISLLP Mvan_3349|M.vanbaalenii_PYR-1 MTHTEAGSAAVATGSWRELLGPKYLGASTVLAGGVALYATNEFLTISLMP MAB_2310|M.abscessus_ATCC_1997 MVRELG------AGGWRDLLDGRQLGIVTVLAGGVALYATNVYLTTSLLP Mflv_3321|M.gilvum_PYR-GCK ----------------------------------MLLAALDQTIVATALP TH_2729|M.thermoresistible__bu --------------------------VLVALILTMALVAMDTTILATAVP MLBr_00556|M.leprae_Br4923 MSTRAG-----------------RRVAISAGSLAVLLGALDTYVVVTIMR : : * : : : : Rv1634|M.tuberculosis_H37Rv STIADIGG----SRLYAWVTTLYLVGSVVAATTVNTMLLRVGARSSYLMG Mb1660|M.bovis_AF2122/97 STIADIGG----SRLYAWVTTLYLVGSVVAATTVNTMLLRVGARSSYLMG MMAR_2438|M.marinum_M STIAEIGG----SRLYAWVTTLYLVGSVVSATTVNAMLLKVGARMSYLMG MUL_1617|M.ulcerans_Agy99 STIAEIGG----SRLYAWVTTLYLVGSVVSATTVNAMLLKVGARMSYLMG MAV_3140|M.avium_104 NTIAEIGG----SRLYAWVTTLYLVGSVVAATMVNPMLLRVGARASYLLG MSMEG_3815|M.smegmatis_MC2_155 SAVADIGG----QRFYAWVTTVYLVASVVAATTVHSVLMRLGPRVAYLVA Mvan_3349|M.vanbaalenii_PYR-1 SAVADIGG----HRFYAWVTTVYLVGSVMAATTVHSVLTRLGPRWAYLLG MAB_2310|M.abscessus_ATCC_1997 SAVVEIGG----ERFYAWVTTVYLIASVSAATVVSPLLGWAGPRGAYLLA Mflv_3321|M.gilvum_PYR-GCK TVVADLGG----AGHQSWVVTSYLLASTIATAIVGKLGDLFGRKMIFGVA TH_2729|M.thermoresistible__bu QVVGDLGG----FDQVGWVFSGYLLAQTVTIPIYGKLADLYGRRPILIFG MLBr_00556|M.leprae_Br4923 DIMHDVGIPVNQMQRITWIVTMYLLGYIAAMPLLSRASDRFGRKLLLQVS : ::* *: : **:. : . * : .. Rv1634|M.tuberculosis_H37Rv LAVFGLASLVCAAA---PSMQILVAGRTLQGIAGGLLAGLGYALINSTLP Mb1660|M.bovis_AF2122/97 LAVFGLASLVCAAA---PSMQILVAGRTLQGIAGGLLAGLGYALINSTLP MMAR_2438|M.marinum_M LTVFGFASLVCAAA---QNMEMLVAGRTLQGVAGGLLAGLGYALINAALP MUL_1617|M.ulcerans_Agy99 LTVFGFASLVCAAA---QNMEMLVAGRTLQGVAGGLLAGLGYALINAALP MAV_3140|M.avium_104 LAVFGVASLVCGAA---PDMHVLIAGRAMQGVAGGLLAGLGYAVINSALP MSMEG_3815|M.smegmatis_MC2_155 LTVFGAGSLGCALA---PSMQLLLAGRLVQGFAGGLLAGLGYAVINTALP Mvan_3349|M.vanbaalenii_PYR-1 LTVFGLGSLVCAVA---PSMEILLAGRTVQGAAGGLLAGLGYAVINTVLP MAB_2310|M.abscessus_ATCC_1997 FGAFAVGTLVCAVA---PGMHVLLAGRAVQGAAGGLLAGLAYAVINLALP Mflv_3321|M.gilvum_PYR-GCK ILFFLAGSVLCGIA---STMEMLVASRALQGIGGGALMVTATALIGEVIP TH_2729|M.thermoresistible__bu VVAFLIGSALSAAS---WNMATLAIFRAIQGLGAGAISATVQTVAGDLYT MLBr_00556|M.leprae_Br4923 LAGFAIGSVMTALAGQFGDFHMLIAGRTIQGVASGALLPITLALGADLWA . * .: . : : * * :** ..* : :: . Rv1634|M.tuberculosis_H37Rv KSLWTRGSALVSAMWGVATLIGPATGGLFAQLG-LWRWAFGVMTLLTALM Mb1660|M.bovis_AF2122/97 KSLWTRGSALVSAMWGVATLIGPATGGLFAQLG-LWRWAFGVMTLLTALM MMAR_2438|M.marinum_M HNLWTRGSALVSAMWGVATLIGPATGGLFAQFG-LWRWAFGVMATMAGLM MUL_1617|M.ulcerans_Agy99 HNLWTCGSALVSAMWGVATLIGPATGGLFAQFG-LWRWAFGVMATMAGLM MAV_3140|M.avium_104 RWLWTRGSALVSAMWGVATVVGPATGGLFAQLG-IWRWAFVVMAVLTALM MSMEG_3815|M.smegmatis_MC2_155 NTLWTKASALVSAMWGVGTVVGPASGGLFAQYG-SWRWAFGVLVILTAAM Mvan_3349|M.vanbaalenii_PYR-1 SVLWKKASALVSAMWGVGTLVGPAAGGLFAQYS-SWRWAFGILVVMTTAM MAB_2310|M.abscessus_ATCC_1997 QGLWTRASALTSAMWGVGTFVGPAAGGLFAQWG-LWRWAFGMLAVITAGI Mflv_3321|M.gilvum_PYR-GCK LRDRGRYQGALGAVFGVTTVIGPLLGGYFTDHL-TWRWAFWINVPIGIVV TH_2729|M.thermoresistible__bu VAERGRIQGYLASVWGISAVIAPALGGFFAQYL-TWRWIFLVNIPIGVFA MLBr_00556|M.leprae_Br4923 QRNRAGVLGGIGAAQELGSVLGPLYGIFIVWLFSDWRYVFWINIPLTAIA . .: : :.:.* * :. **: * : : Rv1634|M.tuberculosis_H37Rv AMLVPVALGAGGVGPGGETPVGSTHKVPVWSLLLMGAAALAISVAALPNY Mb1660|M.bovis_AF2122/97 AMLVPVALGAGRVGPGGETPVGSTHKVPVWSLLLMGAAALAISVAALPNY MMAR_2438|M.marinum_M TLLVLVVLSNG-VAVGGEKPVAPAHKVPVWSLLLMGAAALAVSVAEIPQY MUL_1617|M.ulcerans_Agy99 TLLVLVVLSNG-VAVGGEKPAAPAHKVPVWSLLLMGAAALAVSVAEIPQY MAV_3140|M.avium_104 ALLVPVALARV-----DPAPAIPRMKVPVWSLLIIGVASLAVSVAQIPHN MSMEG_3815|M.smegmatis_MC2_155 AVLVPLALPGRG-----SDTLVPPG-IPVWSLVLLGSAAMAVSVAGIPHD Mvan_3349|M.vanbaalenii_PYR-1 SALVPMALPARARAA-HLGSGAPPGRIPFWSLLLLGAAALLVSVAGIPHD MAB_2310|M.abscessus_ATCC_1997 AAMVPYVLTRAQ----KPNAARAGNQVPVWSLLVLTAAASLVAAAGLQST Mflv_3321|M.gilvum_PYR-GCK LIVALATIPALSRRGKPVIDYAGIVLIGLGASALT--LATSWGGSTYAWS TH_2729|M.thermoresistible__bu LYLIARDLHEDVVRRPHRIDYLGAGLVLVSAGLFI--LGLLSGGVHWSWT MLBr_00556|M.leprae_Br4923 MLMIQVSLSAHDRGDELEKVDVVGGVLLAIALGLVVIGLYNPQPDSKQVL : : : : . Rv1634|M.tuberculosis_H37Rv LVQTAGLLAAAALLVAVFVVVDWRIHAAVLPPSVFG-SGPLKWIYLTMSV Mb1660|M.bovis_AF2122/97 LVQTAGLLAAAALLVAVFVVVDWRIHAAVLPPSVFG-SGPLKWIYLTMSV MMAR_2438|M.marinum_M LVATAGLLVAGALLVGIFVIVDWRMHVAVLPHSVFG-SGPLKWIYLTMSV MUL_1617|M.ulcerans_Agy99 LVATAGLLVAGALLVGIFVIVDWRMHVAVLPHSVFG-SGPLKWIYLTMSV MAV_3140|M.avium_104 TAATFGLLAAGIMLVGLFVIVDWRMHAAILPPSVFS-PGPLKWIYLTMGV MSMEG_3815|M.smegmatis_MC2_155 PRGTAALLLVGVALVVAFIVVDRRAGASVLPPSTFG-PGPLKWIYMSLGV Mvan_3349|M.vanbaalenii_PYR-1 VRATAGLVVAGFVLVAVFVVVDRRVAASVLPPSAFG-RGPLKWIYLTLGG MAB_2310|M.abscessus_ATCC_1997 LPFMATLLAAAVVLVILFVALDRRSRASVLPKAVFA-RNPLKWIYLTIAV Mflv_3321|M.gilvum_PYR-GCK SPMIIGLFVGSAVALAVFVRVELRATEPVLPIRLFASPVFTVCCVLSFIV TH_2729|M.thermoresistible__bu SPTSVVVFTGAALAGVALLVVESRAAEPVLPLSMLTRRLTAPSFAATATA MLBr_00556|M.leprae_Br4923 PSYGVPVLVGGIVATVAFAVWERCARTRLIDPAGVHIRPFLSALGASVAA :. . : : :: . : Rv1634|M.tuberculosis_H37Rv QMIAAMVDTYVPLFGQRLGHLTPVAAGFLGAALAVGWTVGEVASASLNSA Mb1660|M.bovis_AF2122/97 QMIAAMVDTYVPLFGQRLGHLTPVAAGFLGAALAVGWTVGEVASASLNSA MMAR_2438|M.marinum_M QMVAAMVTTYVPLFGQGLGHLTPVAAGFLGAALAFGWTAGEIVSASLTNP MUL_1617|M.ulcerans_Agy99 QMVAAMVTTYVPLFGQGLGHLTPVAAGLLGAALAFGWTAGEIVSASLTNS MAV_3140|M.avium_104 LMAAAMVNTYVPLFGQRLAHLTPIAAGFLGAALALGWTVSEIVSASPENP MSMEG_3815|M.smegmatis_MC2_155 LMAATMVDMYVPLFGQRLAHMTPVVAGFFGAVLSVGWTFGEIASASLQNR Mvan_3349|M.vanbaalenii_PYR-1 LMAATMVDMYVPLFGQRLAHLTPVAAGFLGAGLAIGWTVGEIGSASLTRH MAB_2310|M.abscessus_ATCC_1997 LAVASMAETYIPFFGQRLGHLSPVAAGFLGATLAFGWTVGEMISAS-AQV Mflv_3321|M.gilvum_PYR-GCK GFAMLGALTFLPTFMQFVDGVSATESGLRTLPMVGGLLLTSMGSGVLVSR TH_2729|M.thermoresistible__bu GMIVIGLSVYLPNWGQTVLGLSPVAAGFVLAIMSITWPISSGFSARLYLR MLBr_00556|M.leprae_Br4923 GAALMVTLVNVELFGQGVLGMDQTQAAGLLVWFLIALPIGAVLGGWGATK : : * : : :. : .. Rv1634|M.tuberculosis_H37Rv RVIGHVVAAAPLVMASGLALG-------AVTQRADAPVGIIALWALALLI Mb1660|M.bovis_AF2122/97 RVIGHVVAAAPLVMASGLALG-------AVTQRADAPVGIIALWALALLI MMAR_2438|M.marinum_M RLIGYIIAAAPLVMASGLALG-------AVTQRADASLPTVALWALALLI MUL_1617|M.ulcerans_Agy99 RLIGYIIAVAPLVMASGLALG-------AVTQRADASLPTVALWALALLI MAV_3140|M.avium_104 RTVGRVVMVAPLVAASGLALG-------AVARHGDGSAWTAALWAVALLV MSMEG_3815|M.smegmatis_MC2_155 KVIRRMVAVAPLVMALGLAAG-------AVLVRNGMPVWLVVLWALALLV Mvan_3349|M.vanbaalenii_PYR-1 RVVVRTVAVAPAVMATGLTIG-------ALTQHRDAGPMLVALWAVGLII MAB_2310|M.abscessus_ATCC_1997 RTVSRVVSVAPAVVAAGLFLA-------GVLQRDGATVLEIGCWALGFVV Mflv_3321|M.gilvum_PYR-GCK TGRYKIFPVLGTAVMTVGFVL-------LSQMDATTPVWQQSAY---LFV TH_2729|M.thermoresistible__bu IG-FRDTALVGASCAVAAGTG-------LVLLGPAPPVWQPVVY---TAL MLBr_00556|M.leprae_Br4923 AGDRTMTFVGLLITAGGYWLISHWPVDLLNYRRSIFGLFSVPTMYADLLV : Rv1634|M.tuberculosis_H37Rv IGTGIGIAWPHLTVRAMDSVADPAESSAAAAAINVVQLISGAFGAGLAG- Mb1660|M.bovis_AF2122/97 IGTGIGIAWPHLTVRAMDSVADPAESSAAAAAINVVQLISGAFGAGLAG- MMAR_2438|M.marinum_M TGAGIGIAWPHLTVRAMDCVDDPAESSSAAAAINIVQLVSAAFGAGLAG- MUL_1617|M.ulcerans_Agy99 TGAGIGIAWPHLTVRAMDCVDDPAESSSAAAAINIVQLVSAAFGAGLAG- MAV_3140|M.avium_104 AGTGIGMAWPHLSARAMASVNDPAEGGAASAAINTVQLTSAAIGAGLAG- MSMEG_3815|M.smegmatis_MC2_155 TGAGIGIAWPHLSAWAMSSVDDPAEGPAAAAAINTVQLICGAFGAGLAG- Mvan_3349|M.vanbaalenii_PYR-1 TGAGVGIAWPHLSAWAMSKVDDPAEGPAAAAAINTVQVISAAFGAALAG- MAB_2310|M.abscessus_ATCC_1997 TGAGIGMAWPHLAAAAMSVSDDGSESGTGAAAISTVQLIAGALGAGLAG- Mflv_3321|M.gilvum_PYR-GCK LGTGIGMCMQVLVLIVQSTAN-FSDLGVATSGVTFFRTIGSSFGAAIFGS TH_2729|M.thermoresistible__bu MGAGMGLLFSPLIVGLQNTVG-WDQRGTVTGGLMFSRFLGQSIGAAGFG- MLBr_00556|M.leprae_Br4923 AGLGLGLVIGPLSSATLRVVP-TAQHGIASAAVVVARMTGMLIGVAALTA * *:*: * : :..: : :*.. Rv1634|M.tuberculosis_H37Rv --------------------------------VVVNTAKGGEVAAARGLY Mb1660|M.bovis_AF2122/97 --------------------------------VVVNTAKGGEVAAARGLY MMAR_2438|M.marinum_M --------------------------------VVVNTATGGEVAAARWLY MUL_1617|M.ulcerans_Agy99 --------------------------------VVVNTATGGEVAAARWLY MAV_3140|M.avium_104 --------------------------------VVVNTATGGDEMAAHLLF MSMEG_3815|M.smegmatis_MC2_155 --------------------------------VVVNLVNVGNPSSATWLF Mvan_3349|M.vanbaalenii_PYR-1 --------------------------------VIVNLSHTGDVAAARWLF MAB_2310|M.abscessus_ATCC_1997 --------------------------------VFVNLG-GSARHGAQLLF Mflv_3321|M.gilvum_PYR-GCK LFANFLDSRIGGALAASGAPPEAAQSPQVLHRLPDAVAAPIVEAYSDSLG TH_2729|M.thermoresistible__bu -----------------------AVANAVLRRYEPDTSAAAMGAASHAVF MLBr_00556|M.leprae_Br4923 WGLYRFNQILAG-------LSTAVPPDATLIERAAAVADQAKRAYTMMYS : Rv1634|M.tuberculosis_H37Rv MAFTVLAAAGVIASYQATHRDRRLPR------------------------ Mb1660|M.bovis_AF2122/97 MAFTVLAAAGVIASYQATHRDRRLPR------------------------ MMAR_2438|M.marinum_M TVFTVLAAVGFIASYQATHHDRRSPG------------------------ MUL_1617|M.ulcerans_Agy99 TVFTVLAAVGFIASYQATHHDRRSPG------------------------ MAV_3140|M.avium_104 TVFTALSAAGVAVSYAATRATRQAQPVGNVG------------------- MSMEG_3815|M.smegmatis_MC2_155 AAFAVLAVAGTLASIRAVR------------------------------- Mvan_3349|M.vanbaalenii_PYR-1 ASFAVLAVLATVASTRSGRLRSR--------------------------- MAB_2310|M.abscessus_ATCC_1997 VGFAVMVLCGVVVSVRVFRTGSASEMTDRAGQQAVRIPS----------- Mflv_3321|M.gilvum_PYR-GCK LVFLCAAPVAVIGFVVALTLKQVPLREIEATAALDMGEGFGMPSDDSSER TH_2729|M.thermoresistible__bu VGLLVAAVATVVLLLTVP--RRFPTHHVAVVD------------------ MLBr_00556|M.leprae_Br4923 DIFMITAIVCVIGALLGLLISSRKEHASEPKVPE---------------- : Rv1634|M.tuberculosis_H37Rv -------------------------------------------------- Mb1660|M.bovis_AF2122/97 -------------------------------------------------- MMAR_2438|M.marinum_M -------------------------------------------------- MUL_1617|M.ulcerans_Agy99 -------------------------------------------------- MAV_3140|M.avium_104 -------------------------------------------------- MSMEG_3815|M.smegmatis_MC2_155 -------------------------------------------------- Mvan_3349|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_2310|M.abscessus_ATCC_1997 -------------------------------------------------- Mflv_3321|M.gilvum_PYR-GCK MMETAVGRLVRHSPEIRLRSIAGTHGCDPDVALLWALIQIYRQSQVFGSA TH_2729|M.thermoresistible__bu -------------------------------------------------- MLBr_00556|M.leprae_Br4923 -------------------------------------------------- Rv1634|M.tuberculosis_H37Rv -------------------------------------------------- Mb1660|M.bovis_AF2122/97 -------------------------------------------------- MMAR_2438|M.marinum_M -------------------------------------------------- MUL_1617|M.ulcerans_Agy99 -------------------------------------------------- MAV_3140|M.avium_104 -------------------------------------------------- MSMEG_3815|M.smegmatis_MC2_155 -------------------------------------------------- Mvan_3349|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_2310|M.abscessus_ATCC_1997 -------------------------------------------------- Mflv_3321|M.gilvum_PYR-GCK RLSEIAERLRVPPEVLAPTFDRLVATGRALRTDDQLWLTQSGAQQVSAAT TH_2729|M.thermoresistible__bu -------------------------------------------------- MLBr_00556|M.leprae_Br4923 -------------------------------------------------- Rv1634|M.tuberculosis_H37Rv -------------------------------------------------- Mb1660|M.bovis_AF2122/97 -------------------------------------------------- MMAR_2438|M.marinum_M -------------------------------------------------- MUL_1617|M.ulcerans_Agy99 -------------------------------------------------- MAV_3140|M.avium_104 -------------------------------------------------- MSMEG_3815|M.smegmatis_MC2_155 -------------------------------------------------- Mvan_3349|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_2310|M.abscessus_ATCC_1997 -------------------------------------------------- Mflv_3321|M.gilvum_PYR-GCK AALVSRIVEKLEKSPTFEGRPDWDEVEKALERIAQRLLVQREWEDDRTEL TH_2729|M.thermoresistible__bu -------------------------------------------------- MLBr_00556|M.leprae_Br4923 -------------------------------------------------- Rv1634|M.tuberculosis_H37Rv ----- Mb1660|M.bovis_AF2122/97 ----- MMAR_2438|M.marinum_M ----- MUL_1617|M.ulcerans_Agy99 ----- MAV_3140|M.avium_104 ----- MSMEG_3815|M.smegmatis_MC2_155 ----- Mvan_3349|M.vanbaalenii_PYR-1 ----- MAB_2310|M.abscessus_ATCC_1997 ----- Mflv_3321|M.gilvum_PYR-GCK AAAGK TH_2729|M.thermoresistible__bu ----- MLBr_00556|M.leprae_Br4923 -----