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VTETARETGSWRELLRGHLGTATLLAGGVAMYATNEFLTVSLLPSTIAEIGGSRLYAWVTTLYLVGSVVS ATTVNAMLLKVGARMSYLMGLTVFGFASLVCAAAQNMEMLVAGRTLQGVAGGLLAGLGYALINAALPHNL WTCGSALVSAMWGVATLIGPATGGLFAQFGLWRWAFGVMATMAGLMTLLVLVVLSNGVAVGGEKPAAPAH KVPVWSLLLMGAAALAVSVAEIPQYLVATAGLLVAGALLVGIFVIVDWRMHVAVLPHSVFGSGPLKWIYL TMSVQMVAAMVTTYVPLFGQGLGHLTPVAAGLLGAALAFGWTAGEIVSASLTNSRLIGYIIAVAPLVMAS GLALGAVTQRADASLPTVALWALALLITGAGIGIAWPHLTVRAMDCVDDPAESSSAAAAINIVQLVSAAF GAGLAGVVVNTATGGEVAAARWLYTVFTVLAAVGFIASYQATHHDRRSPG
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. ulcerans Agy99 | MUL_1617 | - | - | 100% (470) | drug efflux membrane protein |
M. ulcerans Agy99 | MUL_3826 | - | 8e-27 | 24.12% (456) | hypothetical protein MUL_3826 |
M. ulcerans Agy99 | MUL_3729 | - | 5e-19 | 23.88% (423) | integral membrane transport protein |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb1660 | - | 0.0 | 79.57% (470) | drug efflux membrane protein |
M. gilvum PYR-GCK | Mflv_3321 | - | 2e-31 | 27.42% (423) | EmrB/QacA family drug resistance transporter |
M. tuberculosis H37Rv | Rv1634 | - | 0.0 | 79.57% (470) | drug efflux membrane protein |
M. leprae Br4923 | MLBr_00556 | - | 4e-14 | 25.32% (474) | putative integral membrane drug transport protein |
M. abscessus ATCC 19977 | MAB_2310 | - | 1e-128 | 52.98% (453) | drug efflux membrane protein |
M. marinum M | MMAR_2438 | - | 0.0 | 98.72% (470) | drug efflux membrane protein |
M. avium 104 | MAV_3140 | - | 1e-179 | 69.30% (469) | drug efflux membrane protein |
M. smegmatis MC2 155 | MSMEG_3815 | - | 1e-152 | 59.70% (464) | drug efflux membrane protein |
M. thermoresistible (build 8) | TH_2729 | - | 4e-21 | 23.65% (427) | PUTATIVE putative drug resistance transporter, EmrB/QacA |
M. vanbaalenii PYR-1 | Mvan_3349 | - | 1e-160 | 63.27% (452) | major facilitator superfamily transporter |
CLUSTAL 2.0.9 multiple sequence alignment MUL_1617|M.ulcerans_Agy99 MTETAR-----ETGSWRELLRG-HLGTATLLAGGVAMYATNEFLTVSLLP MMAR_2438|M.marinum_M MTETAR-----ETGSWRELLSG-HLGTATLLAGGVAMYATNEFLTVSLLP Mb1660|M.bovis_AF2122/97 MTETAS-----ETGSWRELLSR-YLGTSIVLAGGVALYATNEFLTISLLP Rv1634|M.tuberculosis_H37Rv MTETAS-----ETGSWRELLSR-YLGTSIVLAGGVALYATNEFLTISLLP MAV_3140|M.avium_104 MTDAAT-----ITGGWRELLGARYLRTSILLAGGVALYATNEFLTTSLLP MSMEG_3815|M.smegmatis_MC2_155 MTETAA---AEAAGTWRQLLGRRYLGASTVLAGGVLLYATNEFITISLLP Mvan_3349|M.vanbaalenii_PYR-1 MTHTEAGSAAVATGSWRELLGPKYLGASTVLAGGVALYATNEFLTISLMP MAB_2310|M.abscessus_ATCC_1997 MVRELG------AGGWRDLLDGRQLGIVTVLAGGVALYATNVYLTTSLLP Mflv_3321|M.gilvum_PYR-GCK ----------------------------------MLLAALDQTIVATALP TH_2729|M.thermoresistible__bu --------------------------VLVALILTMALVAMDTTILATAVP MLBr_00556|M.leprae_Br4923 MSTRAG-----------------RRVAISAGSLAVLLGALDTYVVVTIMR : : * : : : : MUL_1617|M.ulcerans_Agy99 STIAEIGG----SRLYAWVTTLYLVGSVVSATTVNAMLLKVGARMSYLMG MMAR_2438|M.marinum_M STIAEIGG----SRLYAWVTTLYLVGSVVSATTVNAMLLKVGARMSYLMG Mb1660|M.bovis_AF2122/97 STIADIGG----SRLYAWVTTLYLVGSVVAATTVNTMLLRVGARSSYLMG Rv1634|M.tuberculosis_H37Rv STIADIGG----SRLYAWVTTLYLVGSVVAATTVNTMLLRVGARSSYLMG MAV_3140|M.avium_104 NTIAEIGG----SRLYAWVTTLYLVGSVVAATMVNPMLLRVGARASYLLG MSMEG_3815|M.smegmatis_MC2_155 SAVADIGG----QRFYAWVTTVYLVASVVAATTVHSVLMRLGPRVAYLVA Mvan_3349|M.vanbaalenii_PYR-1 SAVADIGG----HRFYAWVTTVYLVGSVMAATTVHSVLTRLGPRWAYLLG MAB_2310|M.abscessus_ATCC_1997 SAVVEIGG----ERFYAWVTTVYLIASVSAATVVSPLLGWAGPRGAYLLA Mflv_3321|M.gilvum_PYR-GCK TVVADLGG----AGHQSWVVTSYLLASTIATAIVGKLGDLFGRKMIFGVA TH_2729|M.thermoresistible__bu QVVGDLGG----FDQVGWVFSGYLLAQTVTIPIYGKLADLYGRRPILIFG MLBr_00556|M.leprae_Br4923 DIMHDVGIPVNQMQRITWIVTMYLLGYIAAMPLLSRASDRFGRKLLLQVS : ::* *: : **:. : . * : .. MUL_1617|M.ulcerans_Agy99 LTVFGFASLVCAAA---QNMEMLVAGRTLQGVAGGLLAGLGYALINAALP MMAR_2438|M.marinum_M LTVFGFASLVCAAA---QNMEMLVAGRTLQGVAGGLLAGLGYALINAALP Mb1660|M.bovis_AF2122/97 LAVFGLASLVCAAA---PSMQILVAGRTLQGIAGGLLAGLGYALINSTLP Rv1634|M.tuberculosis_H37Rv LAVFGLASLVCAAA---PSMQILVAGRTLQGIAGGLLAGLGYALINSTLP MAV_3140|M.avium_104 LAVFGVASLVCGAA---PDMHVLIAGRAMQGVAGGLLAGLGYAVINSALP MSMEG_3815|M.smegmatis_MC2_155 LTVFGAGSLGCALA---PSMQLLLAGRLVQGFAGGLLAGLGYAVINTALP Mvan_3349|M.vanbaalenii_PYR-1 LTVFGLGSLVCAVA---PSMEILLAGRTVQGAAGGLLAGLGYAVINTVLP MAB_2310|M.abscessus_ATCC_1997 FGAFAVGTLVCAVA---PGMHVLLAGRAVQGAAGGLLAGLAYAVINLALP Mflv_3321|M.gilvum_PYR-GCK ILFFLAGSVLCGIA---STMEMLVASRALQGIGGGALMVTATALIGEVIP TH_2729|M.thermoresistible__bu VVAFLIGSALSAAS---WNMATLAIFRAIQGLGAGAISATVQTVAGDLYT MLBr_00556|M.leprae_Br4923 LAGFAIGSVMTALAGQFGDFHMLIAGRTIQGVASGALLPITLALGADLWA . * .: . : : * * :** ..* : :: . MUL_1617|M.ulcerans_Agy99 HNLWTCGSALVSAMWGVATLIGPATGGLFAQFG-LWRWAFGVMATMAGLM MMAR_2438|M.marinum_M HNLWTRGSALVSAMWGVATLIGPATGGLFAQFG-LWRWAFGVMATMAGLM Mb1660|M.bovis_AF2122/97 KSLWTRGSALVSAMWGVATLIGPATGGLFAQLG-LWRWAFGVMTLLTALM Rv1634|M.tuberculosis_H37Rv KSLWTRGSALVSAMWGVATLIGPATGGLFAQLG-LWRWAFGVMTLLTALM MAV_3140|M.avium_104 RWLWTRGSALVSAMWGVATVVGPATGGLFAQLG-IWRWAFVVMAVLTALM MSMEG_3815|M.smegmatis_MC2_155 NTLWTKASALVSAMWGVGTVVGPASGGLFAQYG-SWRWAFGVLVILTAAM Mvan_3349|M.vanbaalenii_PYR-1 SVLWKKASALVSAMWGVGTLVGPAAGGLFAQYS-SWRWAFGILVVMTTAM MAB_2310|M.abscessus_ATCC_1997 QGLWTRASALTSAMWGVGTFVGPAAGGLFAQWG-LWRWAFGMLAVITAGI Mflv_3321|M.gilvum_PYR-GCK LRDRGRYQGALGAVFGVTTVIGPLLGGYFTDHL-TWRWAFWINVPIGIVV TH_2729|M.thermoresistible__bu VAERGRIQGYLASVWGISAVIAPALGGFFAQYL-TWRWIFLVNIPIGVFA MLBr_00556|M.leprae_Br4923 QRNRAGVLGGIGAAQELGSVLGPLYGIFIVWLFSDWRYVFWINIPLTAIA . .: : :.:.* * :. **: * : : MUL_1617|M.ulcerans_Agy99 TLLVLVVLSNG-VAVGGEKPAAPAHKVPVWSLLLMGAAALAVSVAEIPQY MMAR_2438|M.marinum_M TLLVLVVLSNG-VAVGGEKPVAPAHKVPVWSLLLMGAAALAVSVAEIPQY Mb1660|M.bovis_AF2122/97 AMLVPVALGAGRVGPGGETPVGSTHKVPVWSLLLMGAAALAISVAALPNY Rv1634|M.tuberculosis_H37Rv AMLVPVALGAGGVGPGGETPVGSTHKVPVWSLLLMGAAALAISVAALPNY MAV_3140|M.avium_104 ALLVPVALARV-----DPAPAIPRMKVPVWSLLIIGVASLAVSVAQIPHN MSMEG_3815|M.smegmatis_MC2_155 AVLVPLALPGRG-----SDTLVPPG-IPVWSLVLLGSAAMAVSVAGIPHD Mvan_3349|M.vanbaalenii_PYR-1 SALVPMALPARARAA-HLGSGAPPGRIPFWSLLLLGAAALLVSVAGIPHD MAB_2310|M.abscessus_ATCC_1997 AAMVPYVLTRAQ----KPNAARAGNQVPVWSLLVLTAAASLVAAAGLQST Mflv_3321|M.gilvum_PYR-GCK LIVALATIPALSRRGKPVIDYAGIVLIGLGASALT--LATSWGGSTYAWS TH_2729|M.thermoresistible__bu LYLIARDLHEDVVRRPHRIDYLGAGLVLVSAGLFI--LGLLSGGVHWSWT MLBr_00556|M.leprae_Br4923 MLMIQVSLSAHDRGDELEKVDVVGGVLLAIALGLVVIGLYNPQPDSKQVL : : : : . MUL_1617|M.ulcerans_Agy99 LVATAGLLVAGALLVGIFVIVDWRMHVAVLPHSVFG-SGPLKWIYLTMSV MMAR_2438|M.marinum_M LVATAGLLVAGALLVGIFVIVDWRMHVAVLPHSVFG-SGPLKWIYLTMSV Mb1660|M.bovis_AF2122/97 LVQTAGLLAAAALLVAVFVVVDWRIHAAVLPPSVFG-SGPLKWIYLTMSV Rv1634|M.tuberculosis_H37Rv LVQTAGLLAAAALLVAVFVVVDWRIHAAVLPPSVFG-SGPLKWIYLTMSV MAV_3140|M.avium_104 TAATFGLLAAGIMLVGLFVIVDWRMHAAILPPSVFS-PGPLKWIYLTMGV MSMEG_3815|M.smegmatis_MC2_155 PRGTAALLLVGVALVVAFIVVDRRAGASVLPPSTFG-PGPLKWIYMSLGV Mvan_3349|M.vanbaalenii_PYR-1 VRATAGLVVAGFVLVAVFVVVDRRVAASVLPPSAFG-RGPLKWIYLTLGG MAB_2310|M.abscessus_ATCC_1997 LPFMATLLAAAVVLVILFVALDRRSRASVLPKAVFA-RNPLKWIYLTIAV Mflv_3321|M.gilvum_PYR-GCK SPMIIGLFVGSAVALAVFVRVELRATEPVLPIRLFASPVFTVCCVLSFIV TH_2729|M.thermoresistible__bu SPTSVVVFTGAALAGVALLVVESRAAEPVLPLSMLTRRLTAPSFAATATA MLBr_00556|M.leprae_Br4923 PSYGVPVLVGGIVATVAFAVWERCARTRLIDPAGVHIRPFLSALGASVAA :. . : : :: . : MUL_1617|M.ulcerans_Agy99 QMVAAMVTTYVPLFGQGLGHLTPVAAGLLGAALAFGWTAGEIVSASLTNS MMAR_2438|M.marinum_M QMVAAMVTTYVPLFGQGLGHLTPVAAGFLGAALAFGWTAGEIVSASLTNP Mb1660|M.bovis_AF2122/97 QMIAAMVDTYVPLFGQRLGHLTPVAAGFLGAALAVGWTVGEVASASLNSA Rv1634|M.tuberculosis_H37Rv QMIAAMVDTYVPLFGQRLGHLTPVAAGFLGAALAVGWTVGEVASASLNSA MAV_3140|M.avium_104 LMAAAMVNTYVPLFGQRLAHLTPIAAGFLGAALALGWTVSEIVSASPENP MSMEG_3815|M.smegmatis_MC2_155 LMAATMVDMYVPLFGQRLAHMTPVVAGFFGAVLSVGWTFGEIASASLQNR Mvan_3349|M.vanbaalenii_PYR-1 LMAATMVDMYVPLFGQRLAHLTPVAAGFLGAGLAIGWTVGEIGSASLTRH MAB_2310|M.abscessus_ATCC_1997 LAVASMAETYIPFFGQRLGHLSPVAAGFLGATLAFGWTVGEMISAS-AQV Mflv_3321|M.gilvum_PYR-GCK GFAMLGALTFLPTFMQFVDGVSATESGLRTLPMVGGLLLTSMGSGVLVSR TH_2729|M.thermoresistible__bu GMIVIGLSVYLPNWGQTVLGLSPVAAGFVLAIMSITWPISSGFSARLYLR MLBr_00556|M.leprae_Br4923 GAALMVTLVNVELFGQGVLGMDQTQAAGLLVWFLIALPIGAVLGGWGATK : : * : : :. : .. MUL_1617|M.ulcerans_Agy99 RLIGYIIAVAPLVMASGLALG-------AVTQRADASLPTVALWALALLI MMAR_2438|M.marinum_M RLIGYIIAAAPLVMASGLALG-------AVTQRADASLPTVALWALALLI Mb1660|M.bovis_AF2122/97 RVIGHVVAAAPLVMASGLALG-------AVTQRADAPVGIIALWALALLI Rv1634|M.tuberculosis_H37Rv RVIGHVVAAAPLVMASGLALG-------AVTQRADAPVGIIALWALALLI MAV_3140|M.avium_104 RTVGRVVMVAPLVAASGLALG-------AVARHGDGSAWTAALWAVALLV MSMEG_3815|M.smegmatis_MC2_155 KVIRRMVAVAPLVMALGLAAG-------AVLVRNGMPVWLVVLWALALLV Mvan_3349|M.vanbaalenii_PYR-1 RVVVRTVAVAPAVMATGLTIG-------ALTQHRDAGPMLVALWAVGLII MAB_2310|M.abscessus_ATCC_1997 RTVSRVVSVAPAVVAAGLFLA-------GVLQRDGATVLEIGCWALGFVV Mflv_3321|M.gilvum_PYR-GCK TGRYKIFPVLGTAVMTVGFVL-------LSQMDATTPVWQQSAY---LFV TH_2729|M.thermoresistible__bu IG-FRDTALVGASCAVAAGTG-------LVLLGPAPPVWQPVVY---TAL MLBr_00556|M.leprae_Br4923 AGDRTMTFVGLLITAGGYWLISHWPVDLLNYRRSIFGLFSVPTMYADLLV : MUL_1617|M.ulcerans_Agy99 TGAGIGIAWPHLTVRAMDCVDDPAESSSAAAAINIVQLVSAAFGAGLAG- MMAR_2438|M.marinum_M TGAGIGIAWPHLTVRAMDCVDDPAESSSAAAAINIVQLVSAAFGAGLAG- Mb1660|M.bovis_AF2122/97 IGTGIGIAWPHLTVRAMDSVADPAESSAAAAAINVVQLISGAFGAGLAG- Rv1634|M.tuberculosis_H37Rv IGTGIGIAWPHLTVRAMDSVADPAESSAAAAAINVVQLISGAFGAGLAG- MAV_3140|M.avium_104 AGTGIGMAWPHLSARAMASVNDPAEGGAASAAINTVQLTSAAIGAGLAG- MSMEG_3815|M.smegmatis_MC2_155 TGAGIGIAWPHLSAWAMSSVDDPAEGPAAAAAINTVQLICGAFGAGLAG- Mvan_3349|M.vanbaalenii_PYR-1 TGAGVGIAWPHLSAWAMSKVDDPAEGPAAAAAINTVQVISAAFGAALAG- MAB_2310|M.abscessus_ATCC_1997 TGAGIGMAWPHLAAAAMSVSDDGSESGTGAAAISTVQLIAGALGAGLAG- Mflv_3321|M.gilvum_PYR-GCK LGTGIGMCMQVLVLIVQSTAN-FSDLGVATSGVTFFRTIGSSFGAAIFGS TH_2729|M.thermoresistible__bu MGAGMGLLFSPLIVGLQNTVG-WDQRGTVTGGLMFSRFLGQSIGAAGFG- MLBr_00556|M.leprae_Br4923 AGLGLGLVIGPLSSATLRVVP-TAQHGIASAAVVVARMTGMLIGVAALTA * *:*: * : :..: : :*.. MUL_1617|M.ulcerans_Agy99 --------------------------------VVVNTATGGEVAAARWLY MMAR_2438|M.marinum_M --------------------------------VVVNTATGGEVAAARWLY Mb1660|M.bovis_AF2122/97 --------------------------------VVVNTAKGGEVAAARGLY Rv1634|M.tuberculosis_H37Rv --------------------------------VVVNTAKGGEVAAARGLY MAV_3140|M.avium_104 --------------------------------VVVNTATGGDEMAAHLLF MSMEG_3815|M.smegmatis_MC2_155 --------------------------------VVVNLVNVGNPSSATWLF Mvan_3349|M.vanbaalenii_PYR-1 --------------------------------VIVNLSHTGDVAAARWLF MAB_2310|M.abscessus_ATCC_1997 --------------------------------VFVNLG-GSARHGAQLLF Mflv_3321|M.gilvum_PYR-GCK LFANFLDSRIGGALAASGAPPEAAQSPQVLHRLPDAVAAPIVEAYSDSLG TH_2729|M.thermoresistible__bu -----------------------AVANAVLRRYEPDTSAAAMGAASHAVF MLBr_00556|M.leprae_Br4923 WGLYRFNQILAG-------LSTAVPPDATLIERAAAVADQAKRAYTMMYS : MUL_1617|M.ulcerans_Agy99 TVFTVLAAVGFIASYQATHHDRRSPG------------------------ MMAR_2438|M.marinum_M TVFTVLAAVGFIASYQATHHDRRSPG------------------------ Mb1660|M.bovis_AF2122/97 MAFTVLAAAGVIASYQATHRDRRLPR------------------------ Rv1634|M.tuberculosis_H37Rv MAFTVLAAAGVIASYQATHRDRRLPR------------------------ MAV_3140|M.avium_104 TVFTALSAAGVAVSYAATRATRQAQPVGNVG------------------- MSMEG_3815|M.smegmatis_MC2_155 AAFAVLAVAGTLASIRAVR------------------------------- Mvan_3349|M.vanbaalenii_PYR-1 ASFAVLAVLATVASTRSGRLRSR--------------------------- MAB_2310|M.abscessus_ATCC_1997 VGFAVMVLCGVVVSVRVFRTGSASEMTDRAGQQAVRIPS----------- Mflv_3321|M.gilvum_PYR-GCK LVFLCAAPVAVIGFVVALTLKQVPLREIEATAALDMGEGFGMPSDDSSER TH_2729|M.thermoresistible__bu VGLLVAAVATVVLLLTVP--RRFPTHHVAVVD------------------ MLBr_00556|M.leprae_Br4923 DIFMITAIVCVIGALLGLLISSRKEHASEPKVPE---------------- : MUL_1617|M.ulcerans_Agy99 -------------------------------------------------- MMAR_2438|M.marinum_M -------------------------------------------------- Mb1660|M.bovis_AF2122/97 -------------------------------------------------- Rv1634|M.tuberculosis_H37Rv -------------------------------------------------- MAV_3140|M.avium_104 -------------------------------------------------- MSMEG_3815|M.smegmatis_MC2_155 -------------------------------------------------- Mvan_3349|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_2310|M.abscessus_ATCC_1997 -------------------------------------------------- Mflv_3321|M.gilvum_PYR-GCK MMETAVGRLVRHSPEIRLRSIAGTHGCDPDVALLWALIQIYRQSQVFGSA TH_2729|M.thermoresistible__bu -------------------------------------------------- MLBr_00556|M.leprae_Br4923 -------------------------------------------------- MUL_1617|M.ulcerans_Agy99 -------------------------------------------------- MMAR_2438|M.marinum_M -------------------------------------------------- Mb1660|M.bovis_AF2122/97 -------------------------------------------------- Rv1634|M.tuberculosis_H37Rv -------------------------------------------------- MAV_3140|M.avium_104 -------------------------------------------------- MSMEG_3815|M.smegmatis_MC2_155 -------------------------------------------------- Mvan_3349|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_2310|M.abscessus_ATCC_1997 -------------------------------------------------- Mflv_3321|M.gilvum_PYR-GCK RLSEIAERLRVPPEVLAPTFDRLVATGRALRTDDQLWLTQSGAQQVSAAT TH_2729|M.thermoresistible__bu -------------------------------------------------- MLBr_00556|M.leprae_Br4923 -------------------------------------------------- MUL_1617|M.ulcerans_Agy99 -------------------------------------------------- MMAR_2438|M.marinum_M -------------------------------------------------- Mb1660|M.bovis_AF2122/97 -------------------------------------------------- Rv1634|M.tuberculosis_H37Rv -------------------------------------------------- MAV_3140|M.avium_104 -------------------------------------------------- MSMEG_3815|M.smegmatis_MC2_155 -------------------------------------------------- Mvan_3349|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_2310|M.abscessus_ATCC_1997 -------------------------------------------------- Mflv_3321|M.gilvum_PYR-GCK AALVSRIVEKLEKSPTFEGRPDWDEVEKALERIAQRLLVQREWEDDRTEL TH_2729|M.thermoresistible__bu -------------------------------------------------- MLBr_00556|M.leprae_Br4923 -------------------------------------------------- MUL_1617|M.ulcerans_Agy99 ----- MMAR_2438|M.marinum_M ----- Mb1660|M.bovis_AF2122/97 ----- Rv1634|M.tuberculosis_H37Rv ----- MAV_3140|M.avium_104 ----- MSMEG_3815|M.smegmatis_MC2_155 ----- Mvan_3349|M.vanbaalenii_PYR-1 ----- MAB_2310|M.abscessus_ATCC_1997 ----- Mflv_3321|M.gilvum_PYR-GCK AAAGK TH_2729|M.thermoresistible__bu ----- MLBr_00556|M.leprae_Br4923 -----