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LANSREELVEVFDALDAELDRLDEVSFEVLTTPERLRSLERLECLVRRLPAVGHALINQLDAQASEEELG GTLCCALANRLRITKPDAARRIADAADLGPRRALTGEPLAPQLTATATAQRQGLIGEAHVKVIRALFRPP ARRGGCVHPPGRRSRPGRQSRSISSRRAGPLRPAGHGLATPRRRPHRHRTRPQTRHHPEQPAIRRHVTAK WLPDPPSAGHL*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv1588c | - | - | 100% (222) | Partial REP13E12 repeat protein |
| M. tuberculosis H37Rv | Rv3466 | - | e-125 | 97.75% (222) | hypothetical protein Rv3466 |
| M. tuberculosis H37Rv | Rv0095c | - | 4e-43 | 88.54% (96) | hypothetical protein Rv0095c |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1614c | - | 1e-125 | 98.20% (222) | REP13E12 repeat-containing protein |
| M. gilvum PYR-GCK | Mflv_4397 | - | 5e-20 | 44.26% (122) | hypothetical protein Mflv_4397 |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0394c | - | 1e-21 | 48.70% (115) | hypothetical protein MAB_0394c |
| M. marinum M | MMAR_3121 | - | 1e-42 | 61.76% (136) | hypothetical protein MMAR_3121 |
| M. avium 104 | MAV_2352 | - | 3e-35 | 58.70% (138) | hypothetical protein MAV_2352 |
| M. smegmatis MC2 155 | MSMEG_6573 | - | 1e-13 | 38.40% (125) | hypothetical protein MSMEG_6573 |
| M. thermoresistible (build 8) | TH_3287 | - | 1e-11 | 34.62% (130) | PUTATIVE conserved hypothetical protein |
| M. ulcerans Agy99 | MUL_2371 | - | 2e-42 | 61.03% (136) | hypothetical protein MUL_2371 |
| M. vanbaalenii PYR-1 | Mvan_3050 | - | 1e-22 | 42.65% (136) | hypothetical protein Mvan_3050 |
CLUSTAL 2.0.9 multiple sequence alignment
MAB_0394c|M.abscessus_ATCC_199 -----------MSPIDDLLTTATAVVESS----FDELNNPELLSALRQLE
TH_3287|M.thermoresistible__bu MGQQFVTAGAARARVGELLAAVDAAYAEMRALCLDEVGTGFRLELAERLE
Mflv_4397|M.gilvum_PYR-GCK ---------MSGGDLQTSIAALRAAFEEVAAADVDLLTRPDLVAALDELE
MSMEG_6573|M.smegmatis_MC2_155 ---------MDDG-VQDAVAALDAALNTLLTLPHSALTDAELLTICAGLQ
Mvan_3050|M.vanbaalenii_PYR-1 -------MGCSREDVLGAFDALDAVVESILALDYDALSAAERVRLEARLE
MMAR_3121|M.marinum_M ---MHSNGCSDRESVVATLDRLDRAVDALVEVSFEALTTPERLRVLERLE
MUL_2371|M.ulcerans_Agy99 ---MHSNGCSDRESVVATLDRLDRAVDALVEVSFEALTTPERLRVLERLE
MAV_2352|M.avium_104 ---MHS---STREEIRADVDALRAAVSRVLGHSYDALTTPERLRLLEIFD
Rv1588c|M.tuberculosis_H37Rv ------MLANSREELVEVFDALDAELDRLDEVSFEVLTTPERLRSLERLE
Mb1614c|M.bovis_AF2122/97 ------MLANSREELVEVFDALDAELDRLDEVSFEVLTTPERLRSLERLE
: . . : : ::
MAB_0394c|M.abscessus_ATCC_199 IAQRKITAASHTLTARLVQRGSPVALGGTSFAEVLARYLSITTATARRRL
TH_3287|M.thermoresistible__bu TQCRINRGLMYRVFAQLADPPDEPAMVPAVRDRLWAR-LRITPGEVKRRL
Mflv_4397|M.gilvum_PYR-GCK ELSCQLPAVGHRLLARLQVETSAREMGAKSWNQVLAVRWRISTGEAHRRL
MSMEG_6573|M.smegmatis_MC2_155 DARNRIPAVEHRAIAALSQQTTPAAIGAKSWPLVLATRLGISSKEARRRC
Mvan_3050|M.vanbaalenii_PYR-1 RNLRRIPTVEHELLASVIAETEPARLGEGSWKKVLTTALRISGAEAGRRL
MMAR_3121|M.marinum_M VVARRLPVAQYALLNQLDEQAGEAELGGR-LAAVVASRLRITRSEAGRRV
MUL_2371|M.ulcerans_Agy99 VVARRLPAAQYALVNQLDEQPGEAELGGR-LAAVVASRLRITRSEAGRRV
MAV_2352|M.avium_104 RETRRLRVPGHQLINQLAEQSDPTELGGR-LSFALAERLHITRSDASRRI
Rv1588c|M.tuberculosis_H37Rv CLVRRLPAVGHALINQLDAQASEEELGGT-LCCALANRLRITKPDAARRI
Mb1614c|M.bovis_AF2122/97 CLVRRLPAVGHTLINQLDTQASEEELGGT-LCCALANRLRITKPDAALRI
: : : : *: . *
MAB_0394c|M.abscessus_ATCC_199 ADAAHLGPRRALTGEPLRPALPYVAHALREGRLGDEHVRIIRRFFDVLPD
TH_3287|M.thermoresistible__bu RVAALLRPRRRLSGPPLPPVLARVAGAVESGLLGEEHLRVITTVMAALPS
Mflv_4397|M.gilvum_PYR-GCK TEAALLAPRQSLTGTPLPPALPATAVAQSRGLINAEHVEVIRKAVKKLPG
MSMEG_6573|M.smegmatis_MC2_155 TDAAELGPRVSMTGEALAPKREHIAAAQADGTLTPDHVAELFKFFTKCPD
Mvan_3050|M.vanbaalenii_PYR-1 KRAKTLGPRRGLTGTPLPPLWESTAAAQAQGLLSEEHVAVIAAFHKRLPA
MMAR_3121|M.marinum_M AEAADVGPRRALSGQPVGPVLTATAAALRQGVVGEGHVRVIRDFFRRLPA
MUL_2371|M.ulcerans_Agy99 AEAAEVGPRRALSGQPVGPVLTATAAALRQGVVGEGHVRVIRDFFRQLPA
MAV_2352|M.avium_104 AEAADLGPRRALTGEPLPPLLPATAAAQRDGAIGTDHVAVIRQFFDQLPE
Rv1588c|M.tuberculosis_H37Rv ADAADLGPRRALTGEPLAPQLTATATAQRQGLIGEAHVKVIRALFR----
Mb1614c|M.bovis_AF2122/97 ADAADLGPRRALTGEPLAPQLTATATAQRQGLIGEAHIKVIRALFR----
* : ** ::* .: * * * * : *: :
MAB_0394c|M.abscessus_ATCC_199 AVDADTREAAEKQLASMGTEFGPEQLRAGADRIAALVNPDG-RFSDIDRA
TH_3287|M.thermoresistible__bu AVSVTDREAVEASLIAEAARSDAGIVRQVGRRIEEIFNPDG-HYDDQDRA
Mflv_4397|M.gilvum_PYR-GCK WVDVATREQFEVNLVRTAVGNGPKELRDAAELTLFLLDQDGPEPDDTERA
MSMEG_6573|M.smegmatis_MC2_155 WVTYAEQCRLEEKLVTGAIGADPETVRQAVDHAVFLLDQDGPAPTDNPPT
Mvan_3050|M.vanbaalenii_PYR-1 WVDIETRAEADRQLAHAGSGLDPEGLDEAAGVLLAMINPDGAQPCDKERA
MMAR_3121|M.marinum_M GVDVGTRDRAEAHLAKLATQFRPDQLARLAGRLMDCLNPDG-RHSDEDRA
MUL_2371|M.ulcerans_Agy99 GVDVGTRDRAEAHLAKLATQFRPDQLARLAGRLMDCLNPDG-RHSDEDRA
MAV_2352|M.avium_104 AVDVETCEHAERQLAAQATQFRPDQLSKLARRLMDCLNPDG-RYSDEDRA
Rv1588c|M.tuberculosis_H37Rv ----------------------------PPARRGGCVHPPG------RRS
Mb1614c|M.bovis_AF2122/97 ----------------------------PPARRGGCVHPPG------RRS
.. * :
MAB_0394c|M.abscessus_ATCC_199 RRRGISIGRQGADGMSALSGLLDPETRAYFDAVLSKLAAPGMCDPRD---
TH_3287|M.thermoresistible__bu RRRGIHLGDQQRDGMSAISGWIDPQLRAYLEAVTAAVR-PGRHLPHTTTD
Mflv_4397|M.gilvum_PYR-GCK RKRGLTKGKQRPDGMIDLAGTLTPEAWAVLEVIFAKYAAPGMCNPAD---
MSMEG_6573|M.smegmatis_MC2_155 KPFGITFGPQQPDGSYHLRGKVSAEFKATFDPIDEKLAAPGMCNPTD---
Mvan_3050|M.vanbaalenii_PYR-1 RKRGIRISKQHPDGTATISGTLTPEALAIWQAIFAKEAAPGANNPESEH-
MMAR_3121|M.marinum_M RRRGLSLGRQGLDGMSRISGWLTPEARAGLEAVWAKLAAPGMCNPED---
MUL_2371|M.ulcerans_Agy99 RRRGLSLGRQGLDGMSRISGWLTPEARAGLEAVWAKLAAPGMCNPED---
MAV_2352|M.avium_104 RARGLVLGNQQADGMSRLSGWLTPEARAGWEAVLAKLAAPGMCNPDD---
Rv1588c|M.tuberculosis_H37Rv RP-----GRQS---------------------------------------
Mb1614c|M.bovis_AF2122/97 RP-----GRQS---------------------------------------
: . *
MAB_0394c|M.abscessus_ATCC_199 --------ESPMTEG------------------------------EPDSA
TH_3287|M.thermoresistible__bu TTGTTGTTETTGTAG------------------------------TAGTA
Mflv_4397|M.gilvum_PYR-GCK --------PEPCTYG------------------------------TPTQA
MSMEG_6573|M.smegmatis_MC2_155 --------QTPCISG------------------------------TPSQQ
Mvan_3050|M.vanbaalenii_PYR-1 --------TEDSTSGGAADDASDAPGDHAGAASSAASGASDAAEHDPQPE
MMAR_3121|M.marinum_M --------EAAVVDG------------------------------PVSPD
MUL_2371|M.ulcerans_Agy99 --------EAAVVDG------------------------------PVSRD
MAV_2352|M.avium_104 --------DAPVVDG------------------------------PPPEA
Rv1588c|M.tuberculosis_H37Rv --------------------------------------------------
Mb1614c|M.bovis_AF2122/97 --------------------------------------------------
MAB_0394c|M.abscessus_ATCC_199 AAERDT---------------RTSAQRNHDGLRACLRSTLASGKLGAHRG
TH_3287|M.thermoresistible__bu ATAADTAADGVGDIDTGGVDLRSAAQRRHDGLTLGLKIAVASGRLGSHRG
Mflv_4397|M.gilvum_PYR-GCK QIDNDQ---------------RSLAQRQHDALVAVGRIALMSGELGQLNG
MSMEG_6573|M.smegmatis_MC2_155 QIDSDQ---------------RGAPERRHDAMLTAMRLLLAHKDLGQING
Mvan_3050|M.vanbaalenii_PYR-1 RCGSDT---------------RTQAQRNHDAFLAVGRRLLESGELGTHNG
MMAR_3121|M.marinum_M AADRDS---------------RSVGQRQHDGFNAALRAVLASGELGQHNG
MUL_2371|M.ulcerans_Agy99 AADRDS---------------RSVSQRQHDGFNAALRAVLASGELGQHNG
MAV_2352|M.avium_104 ASQRDS---------------RSAAQRNHDGLNAALRALLAGGKLGQHNG
Rv1588c|M.tuberculosis_H37Rv ---------------------RSISSRRAG--------------------
Mb1614c|M.bovis_AF2122/97 ---------------------RSISSRRAG--------------------
* .*. .
MAB_0394c|M.abscessus_ATCC_199 LPVTVVVSTTLRELQSAA-----------GRAISGSGNLVPIPDLIRMAT
TH_3287|M.thermoresistible__bu HPVTVIVRTTLGELNQAAHAVADPRVSMPGPARTGGTGVLPMRELIRMAA
Mflv_4397|M.gilvum_PYR-GCK LPVSIIIRTTLQDLESRA-----------GVGTTGGGTVVPIKDVIRMAG
MSMEG_6573|M.smegmatis_MC2_155 LPATLLVTTTLQELEKAA-----------GVAITAGGTKLSIPDLIRLAS
Mvan_3050|M.vanbaalenii_PYR-1 LPVTVIVSTTLQELEKGA-----------GVAVTGGGSLLPMPDLIRLAA
MMAR_3121|M.marinum_M LPASIIVSTTLKELEAAA-----------GRGLTGGGTLLPMSDVIRLAR
MUL_2371|M.ulcerans_Agy99 LPASIIVSTTLKELEAAA-----------GRGLTGGGTLLPMSDVIRLAR
MAV_2352|M.avium_104 LPASIIVTTTLRDLESAA-----------GKGLTGGGTLLPMSEVIRLAR
Rv1588c|M.tuberculosis_H37Rv --------------------------------------------PLRPAG
Mb1614c|M.bovis_AF2122/97 --------------------------------------------PLRPAG
:* *
MAB_0394c|M.abscessus_ATCC_199 HAFHYLTIFGDD-GRPLHLGRSKRIATPDQRIVLHAKDRGCSAPGCTVPG
TH_3287|M.thermoresistible__bu DAIHYLAVFDDHTERPLYLGRQKRIATADQRLICYARDGGCTAPGCGEPG
Mflv_4397|M.gilvum_PYR-GCK HANHYLAVFDRATGSALDLFRTRRVASPAQRVMLIARDGGCTKPCCTVGA
MSMEG_6573|M.smegmatis_MC2_155 QALHYLAVYDEHTGIPLYLGRARRTASAGQRLAIWARDRGCTRPGCTANG
Mvan_3050|M.vanbaalenii_PYR-1 RAHHYLYVYDQHSGKSLYLGRAKRLANAAQRIVLHARDRGCTRPGCTAPG
MMAR_3121|M.marinum_M HAHHYLAVFDRG--EAIGLYHAKRLATPGQRIVLYAKDRGCTRPGCDVAG
MUL_2371|M.ulcerans_Agy99 HAHHYLAVFDRG--EAIGLYHAKRLATPGQRIVLYAKDRGCTRPGCDVAG
MAV_2352|M.avium_104 HAHHYLAVFDNG--KPLALYHTKRLASPGQRIVLYAKDRGCSHPGCDVSG
Rv1588c|M.tuberculosis_H37Rv HG----------------------LATPRRRPHRHR-----TRPQTR---
Mb1614c|M.bovis_AF2122/97 HG----------------------LATPRRRPHRHR-----TRPQTR---
. *.. :* : *
MAB_0394c|M.abscessus_ATCC_199 YLCQVHHVD-DWRDDGPTDIDNLTFACGPHHRLLQQGW--TTRKRRSDGI
TH_3287|M.thermoresistible__bu YHAETHHQP-AWEDGGLTDADHLFFACGPHHSGLTEGR--WQATITPTGR
Mflv_4397|M.gilvum_PYR-GCK YGCQVHHAETDYAHGGNTNIDELGLACGPDNRSVTEGG--WTTRINDRCE
MSMEG_6573|M.smegmatis_MC2_155 YRCQAHHATTDYAKGGLTDADALALACGCDNRLVGEAPNKWTTRINNHGQ
Mvan_3050|M.vanbaalenii_PYR-1 YWCQAHHASADFVDGGLTNIDDLTLACPCDHRMLDNTG--WRTRKNGKNQ
MMAR_3121|M.marinum_M YQCEVHHVA-AWAISGRTDINQLTLACGPDHK-LLEQG--WRTRKNAHGD
MUL_2371|M.ulcerans_Agy99 YQCEVHHVA-AWAISGRTDINQLTLACGPDHK-LLEQG--WRTRKNAHGD
MAV_2352|M.avium_104 YYCEVHHVT-GYAKCGRTDIDQLTFACGGHHP-LAEQG--WITRKNGRGE
Rv1588c|M.tuberculosis_H37Rv -----HHPE--------------------------------QPAIRRHVT
Mb1614c|M.bovis_AF2122/97 -----HHPE--------------------------------QPAIRRHVT
**
MAB_0394c|M.abscessus_ATCC_199 TEWIPPPHLDTGQSRTNDHHHPERFIRRF---------------------
TH_3287|M.thermoresistible__bu LAWTNDHHPPT----VNHAHHPEELLRAHT--------------------
Mflv_4397|M.gilvum_PYR-GCK VEWIPPPGLDTGQARVNTYHRPERLLAPP---------------------
MSMEG_6573|M.smegmatis_MC2_155 CEWIPPDLLDRGQHRTNTYHHPETLLADINRDQKTDGDNREQHHTDTGAD
Mvan_3050|M.vanbaalenii_PYR-1 TEWLPPPDLDTGQHRVNGHHHPERYLLPE---------------------
MMAR_3121|M.marinum_M TEWLPPPHLDHGQPRTNTYHHPEKLLRDS---------------------
MUL_2371|M.ulcerans_Agy99 TEWLPPPHLDHGQPRTNSYHHPEKLLRDS---------------------
MAV_2352|M.avium_104 TEWIPPPHLERGQPRVNSFHHPEDMLCDT---------------------
Rv1588c|M.tuberculosis_H37Rv AKWLPDP--------PSAGHL-----------------------------
Mb1614c|M.bovis_AF2122/97 AKWLPDP--------PSAGHL-----------------------------
* . *
MAB_0394c|M.abscessus_ATCC_199 --------------------------------------------------
TH_3287|M.thermoresistible__bu ----------------------------------DPPEDPG---------
Mflv_4397|M.gilvum_PYR-GCK ----------DDPEPP------NQTRTTATEPVEDQAIDDPETDAPPPLD
MSMEG_6573|M.smegmatis_MC2_155 TGTVHVNGHGEKPAIPPELLDQGQQRTAPYHQAEVPPVNTRDTRSSTTTR
Mvan_3050|M.vanbaalenii_PYR-1 ---------------------------------DDLPEDDQGP-------
MMAR_3121|M.marinum_M -------------------------------------ADDDD--------
MUL_2371|M.ulcerans_Agy99 -------------------------------------ADDDD--------
MAV_2352|M.avium_104 -------------------------------------EDQQDQQDQQDQA
Rv1588c|M.tuberculosis_H37Rv --------------------------------------------------
Mb1614c|M.bovis_AF2122/97 --------------------------------------------------
MAB_0394c|M.abscessus_ATCC_199 --------------------------------
TH_3287|M.thermoresistible__bu --------------------------------
Mflv_4397|M.gilvum_PYR-GCK DPGEPGGP----------APPDNRAA------
MSMEG_6573|M.smegmatis_MC2_155 DANRHNGNGDRNSAENRNGPSKNAAGDDDEPR
Mvan_3050|M.vanbaalenii_PYR-1 --------------------------------
MMAR_3121|M.marinum_M -EGHGAA-------------------------
MUL_2371|M.ulcerans_Agy99 -EGHGAA-------------------------
MAV_2352|M.avium_104 DEEDGAA-------------------------
Rv1588c|M.tuberculosis_H37Rv --------------------------------
Mb1614c|M.bovis_AF2122/97 --------------------------------