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LAKLAAPGATNPDDHTPVIDTTPDAAAIDRDTRSQAQRNHDGLLAGLRALIASGKLGQHNGLPVSIVVTT TLTDLQTGAGKGFTGGGTLLPMADVIRMTSHAHHYSPASGRYPQAIFDHGTPLALYHTKRLASPAQRIML FANDRGCTKPGCDAPAYHSQAHHVTAWTSTGRTDITELTLACGPDNRLAEKGWTTHNNTHGHTEWLPPPH LDHGQPWTCEIHYTCACCCLPPNLRRPLRRTARRGPPTRGLPKAVRAAKMGARRVPRQRRQRINRQAPPR LRADVGRHHRRQDRRRGGLGPGPAPSPSHRAGSLHVISRREAAGPGHRRRRR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv1587c | - | - | 100% (333) | Partial REP13E12 repeat protein |
| M. tuberculosis H37Rv | Rv3467 | - | e-131 | 97.77% (224) | hypothetical protein Rv3467 |
| M. tuberculosis H37Rv | Rv0094c | - | e-131 | 97.77% (224) | hypothetical protein Rv0094c |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1613c | - | 0.0 | 98.20% (333) | REP13E12 repeat-containing protein |
| M. gilvum PYR-GCK | Mflv_1835 | - | 2e-59 | 54.09% (220) | hypothetical protein Mflv_1835 |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0394c | - | 1e-66 | 53.78% (225) | hypothetical protein MAB_0394c |
| M. marinum M | MMAR_1523 | - | 3e-82 | 61.16% (224) | hypothetical protein MMAR_1523 |
| M. avium 104 | MAV_4180 | - | 2e-84 | 65.78% (225) | hypothetical protein MAV_4180 |
| M. smegmatis MC2 155 | MSMEG_2663 | - | 4e-52 | 47.14% (227) | hypothetical protein MSMEG_2663 |
| M. thermoresistible (build 8) | TH_3287 | - | 2e-35 | 41.50% (200) | PUTATIVE conserved hypothetical protein |
| M. ulcerans Agy99 | MUL_2371 | - | 3e-81 | 60.71% (224) | hypothetical protein MUL_2371 |
| M. vanbaalenii PYR-1 | Mvan_4827 | - | 1e-62 | 55.66% (221) | hypothetical protein Mvan_4827 |
CLUSTAL 2.0.9 multiple sequence alignment
Rv1587c|M.tuberculosis_H37Rv --------------------------------------------------
Mb1613c|M.bovis_AF2122/97 --------------------------------------------------
Mflv_1835|M.gilvum_PYR-GCK ----MYVRVMSGGDLQTRIAVLRAAFDEVAACEIELLTRPDLVAALDELE
Mvan_4827|M.vanbaalenii_PYR-1 ----MYVRAMSGSDVQAAVTALRTAFDDMAACDVDLLTRPDLVAALDELE
MSMEG_2663|M.smegmatis_MC2_155 -MIRTSVRYMA-AEVGTALAALHAAMRDVLALPYTALSDADLLDVCAGIQ
MMAR_1523|M.marinum_M ---MSS---MSREEVVAAFDALDAVMARLQDLCFDGLTTPERLALLQRCE
MUL_2371|M.ulcerans_Agy99 ---MHSNGCSDRESVVATLDRLDRAVDALVEVSFEALTTPERLRVLERLE
MAV_4180|M.avium_104 ---MSS----DREAVSAAFDVIDAALDDLLDCDYAVLATREKLALLNRCE
MAB_0394c|M.abscessus_ATCC_199 ---------------MSPIDDLLTTATAVVESSFDELNNPELLSALRQLE
TH_3287|M.thermoresistible__bu MGQQFVTAGAARARVGELLAAVDAAYAEMRALCLDEVGTGFRLELAERLE
Rv1587c|M.tuberculosis_H37Rv --------------------------------------------------
Mb1613c|M.bovis_AF2122/97 --------------------------------------------------
Mflv_1835|M.gilvum_PYR-GCK ELSCQLPAVGHRLLARLQAEGTPQQMGAKNWSEVLRVRWRISGSEAHRRL
Mvan_4827|M.vanbaalenii_PYR-1 TVGCRLPALSYRLLARLQAETTPPQMGAKSWKEVLAVRWRISTSEAHRRL
MSMEG_2663|M.smegmatis_MC2_155 DVRNLAPAVEHRAIAALSEQTTPAAIGAKSWPLVLATRLGISSKEARRRC
MMAR_1523|M.marinum_M VARRRLPSIEHPLINQLVEQAGEQELGGK-LAAVLAGRLRVSRGEASRRL
MUL_2371|M.ulcerans_Agy99 VVARRLPAAQYALVNQLDEQPGEAELGGR-LAAVVASRLRITRSEAGRRV
MAV_4180|M.avium_104 KLRRRLPAVEHPLINALARDASPAELGGR-LSHAIAEATLISRAEAARRV
MAB_0394c|M.abscessus_ATCC_199 IAQRKITAASHTLTARLVQRGSPVALGGTSFAEVLARYLSITTATARRRL
TH_3287|M.thermoresistible__bu TQCRINRGLMYRVFAQLADPPDEPAMVPAVRDRLWAR-LRITPGEVKRRL
Rv1587c|M.tuberculosis_H37Rv --------------------------------------------------
Mb1613c|M.bovis_AF2122/97 --------------------------------------------------
Mflv_1835|M.gilvum_PYR-GCK TEAALLAPRPSLTGPALPPQLAATAIAQARGLINAEHVAVIRKAVKKLPG
Mvan_4827|M.vanbaalenii_PYR-1 TEAAVLAPRQAMTGEALPPVLPATAAAQAHGLINAEHVEVIRKAMAKLPG
MSMEG_2663|M.smegmatis_MC2_155 ADAAELGPRVSLTGEALAPKREHIAAAQADGALTPDHVTELFKFFTKCPD
MMAR_1523|M.marinum_M REAADLGPRRALTGEQLAPLLSATASAVRQGRIGAGHVRVIREFCGQVPA
MUL_2371|M.ulcerans_Agy99 AEAAEVGPRRALSGQPVGPVLTATAAALRQGVVGEGHVRVIRDFFRQLPA
MAV_4180|M.avium_104 HTAADLGPRVGLTGEPLPPVLAATAAAQRAGSLGPEQVAVIRKFCHQLPG
MAB_0394c|M.abscessus_ATCC_199 ADAAHLGPRRALTGEPLRPALPYVAHALREGRLGDEHVRIIRRFFDVLPD
TH_3287|M.thermoresistible__bu RVAALLRPRRRLSGPPLPPVLARVAGAVESGLLGEEHLRVITTVMAALPS
Rv1587c|M.tuberculosis_H37Rv --------------------------------------------------
Mb1613c|M.bovis_AF2122/97 --------------------------------------------------
Mflv_1835|M.gilvum_PYR-GCK WVDVATREQFEVNLVRTAVGHGPKELNDAADRMLFLLDQDGPEPDDAERG
Mvan_4827|M.vanbaalenii_PYR-1 FVDTATRERIEVDLVRTAVGNGPKELKDSADRTLFLLDQDGPEPDERERA
MSMEG_2663|M.smegmatis_MC2_155 WVTYAEQCRLEEKLVTGAIGADPETVRQAVDHAVFLLDQDGPAPTDNPPT
MMAR_1523|M.marinum_M EVDLETRERAEAHLARLAGQFRPDQLAKLAQRLMDCVNPDGRYSDE-DRA
MUL_2371|M.ulcerans_Agy99 GVDVGTRDRAEAHLAKLATQFRPDQLARLAGRLMDCLNPDGRHSDE-DRA
MAV_4180|M.avium_104 WIDQATRERAETDLAREGTRYRPEQLAALAGTLADCLNPDGLYRDE-DRA
MAB_0394c|M.abscessus_ATCC_199 AVDADTREAAEKQLASMGTEFGPEQLRAGADRIAALVNPDGR-FSDIDRA
TH_3287|M.thermoresistible__bu AVSVTDREAVEASLIAEAARSDAGIVRQVGRRIEEIFNPDGHYDDQ-DRA
Rv1587c|M.tuberculosis_H37Rv --------------------------------MLAKLAAP----------
Mb1613c|M.bovis_AF2122/97 --------------------------------MLAKLAAP----------
Mflv_1835|M.gilvum_PYR-GCK RKRGVSIGRQGAEAMSALTGQLTPEARAVWEAIFAKYAAP----------
Mvan_4827|M.vanbaalenii_PYR-1 RKRAVTKHKQREDGMVDVSATLTPEAWAVWEAIFAKFAAP----------
MSMEG_2663|M.smegmatis_MC2_155 KPFGITFGPQQPDGSYHLRGKVSAEFKATFDPIDEKLAAP----------
MMAR_1523|M.marinum_M RRRGLTLGRQGRDGMSRISGWLTPEARAGLDAVLAKLAAP----------
MUL_2371|M.ulcerans_Agy99 RRRGLSLGRQGLDGMSRISGWLTPEARAGLEAVWAKLAAP----------
MAV_4180|M.avium_104 RRRSLTLGNQHADGMSELRGLLTPELRATLEAVLAKLAAP----------
MAB_0394c|M.abscessus_ATCC_199 RRRGISIGRQGADGMSALSGLLDPETRAYFDAVLSKLAAP----------
TH_3287|M.thermoresistible__bu RRRGIHLGDQQRDGMSAISGWIDPQLRAYLEAVTAAVRPGRHLPHTTTDT
: .
Rv1587c|M.tuberculosis_H37Rv ----------GATNPDDHTPVIDTTPDAAAIDRDT-----RSQAQRNHDG
Mb1613c|M.bovis_AF2122/97 ----------GATNPDDHTPVIDTTPDAAAIDRDT-----RSQAQRNHDG
Mflv_1835|M.gilvum_PYR-GCK ----------GMCNPDDEQPCTSGTPSQAQIDGDH-----RSLAQRQHDA
Mvan_4827|M.vanbaalenii_PYR-1 ----------GMCNPDDPEPCTSGTPSQAQIDNDH-----RSLAQRQHDA
MSMEG_2663|M.smegmatis_MC2_155 ----------GMCNPTDQTPCISGTPSQQQIDHDE-----RGAPERRHDA
MMAR_1523|M.marinum_M ----------GMCNPDDESPVVQAPAGADAVSRDR-----RSVGQRHHDG
MUL_2371|M.ulcerans_Agy99 ----------GMCNPEDEAAVVDGPVSRDAADRDS-----RSVSQRQHDG
MAV_4180|M.avium_104 ----------GMCNPLDESPCVDGTPTEQAIEGDT-----RSAAQRNHDG
MAB_0394c|M.abscessus_ATCC_199 ----------GMCDPRDESPMTEGEPDSAAAERDT-----RTSAQRNHDG
TH_3287|M.thermoresistible__bu TGTTGTTETTGTAGTAGTAATAADTAADGVGDIDTGGVDLRSAAQRRHDG
* .. . . . * * :*.**.
Rv1587c|M.tuberculosis_H37Rv LLAGLRALIASGKLGQHNGLPVSIVVTTTLTDLQTGA-----------GK
Mb1613c|M.bovis_AF2122/97 LLAGLRALIASGELGQHNGLPVSIVVTTTLTDLQTGA-----------GK
Mflv_1835|M.gilvum_PYR-GCK LLAVGRIALMSGELGQLNGLPVSVIIRTTLQDLESRA-----------GI
Mvan_4827|M.vanbaalenii_PYR-1 LLAGGRIALMSGQLGQLNGLPVSVIIRTTLQDLESRA-----------GV
MSMEG_2663|M.smegmatis_MC2_155 MLTAMRLLLAHKDLGQINGLPATLLITTTLQELEKAA-----------GV
MMAR_1523|M.marinum_M LNAAVRALLASGDLGQHNGLPASIIVTTTLGELQRAC-----------GR
MUL_2371|M.ulcerans_Agy99 FNAALRAVLASGELGQHNGLPASIIVSTTLKELEAAA-----------GR
MAV_4180|M.avium_104 LLAGLRALLASGNLGQHNGLPASIIVTTTLADLQAAA-----------GK
MAB_0394c|M.abscessus_ATCC_199 LRACLRSTLASGKLGAHRGLPVTVVVSTTLRELQSAA-----------GR
TH_3287|M.thermoresistible__bu LTLGLKIAVASGRLGSHRGHPVTVIVRTTLGELNQAAHAVADPRVSMPGP
: : : ** .* *.:::: *** :*: . *
Rv1587c|M.tuberculosis_H37Rv GFTGGGTLLPMADVIRMTSHAHHYSPASGRYPQAIFDHGTPLALYHTKRL
Mb1613c|M.bovis_AF2122/97 GFTGGGTLLPMADVIRMTSHAHHYSPASGRYPQAIFDHGTPLALYHTKRL
Mflv_1835|M.gilvum_PYR-GCK GVSGGGTKLPIRDVIRMAGHANHYLAVFDRA------TGSALDLFRTRRV
Mvan_4827|M.vanbaalenii_PYR-1 GVTGGGTVMPIAEVIRMAGHAHHYLAVFDRA------TGSALDLFRTRRI
MSMEG_2663|M.smegmatis_MC2_155 AITAGGTKLSIPDLIRLASQALHYLAVYDEH------TGVPLYLGRARRT
MMAR_1523|M.marinum_M GLTGGGTVLPISDVIRLARHAHHYLAVFDRG--------KAVGLYHAKRL
MUL_2371|M.ulcerans_Agy99 GLTGGGTLLPMSDVIRLARHAHHYLAVFDRG--------EAIGLYHAKRL
MAV_4180|M.avium_104 GLTGGGTLLPMSDVIRLSRHAHHYLAIFDHG--------KALALYHTKRL
MAB_0394c|M.abscessus_ATCC_199 AISGSGNLVPIPDLIRMATHAFHYLTIFGDD-------GRPLHLGRSKRI
TH_3287|M.thermoresistible__bu ARTGGTGVLPMRELIRMAADAIHYLAVFDDH------TERPLYLGRQKRI
. :.. :.: ::**:: .* ** . . .: * : :*
Rv1587c|M.tuberculosis_H37Rv ASPAQRIMLFANDRGCTKPGCDAPAYHSQAHHVTA-WTSTGRTDITELTL
Mb1613c|M.bovis_AF2122/97 ASPAQRIMLFANDRGCTKPGCDAPAYHSQAHHVTG-WTSTGRTDITDLTL
Mflv_1835|M.gilvum_PYR-GCK ASPAQRVMLIARDGGCTKPCCTVGAYGCQVHHAEADYAHGGNTNIDELGL
Mvan_4827|M.vanbaalenii_PYR-1 ASPAQRIMLIARDGGCTKPGCPVGAYGCQGHHVEADFAQGGNTNVDELGL
MSMEG_2663|M.smegmatis_MC2_155 ASAGQRLAIWARDRGCTRPGCTANGYRCQAHHATTDYAKGGLTDADALAL
MMAR_1523|M.marinum_M ATAGQRLVLYAKDRGCTRPGCDVPGYQCEVHHVAA-WATSGRTDIDQLTL
MUL_2371|M.ulcerans_Agy99 ATPGQRIVLYAKDRGCTRPGCDVAGYQCEVHHVAA-WAISGRTDINQLTL
MAV_4180|M.avium_104 ASPAQRIVLYAKDRGCTAPGCTVPGYYAEVHHCTD-YATCHTTDINDLTF
MAB_0394c|M.abscessus_ATCC_199 ATPDQRIVLHAKDRGCSAPGCTVPGYLCQVHHVDD-WRDDGPTDIDNLTF
TH_3287|M.thermoresistible__bu ATADQRLICYARDGGCTAPGCGEPGYHAETHHQPA-WEDGGLTDADHLFF
*:. **: *.* **: * * .* .: ** : *: * :
Rv1587c|M.tuberculosis_H37Rv ACGPDNRLAEKG---WTTHNN-THGHTEWLPPPHLDHGQPWTCEIHYTCA
Mb1613c|M.bovis_AF2122/97 ACDPDNRLAEKG---WTTRKN-THGHTEWLPPPHLDHGQPWTCEIHYTCA
Mflv_1835|M.gilvum_PYR-GCK ACGPDNRSVTD--GGWTTRMN-DRCEVEWIPPPGLDTGQARVNTYHR---
Mvan_4827|M.vanbaalenii_PYR-1 ACGPDNRDVNDH-GGWTTQMN-ERCEVEWTPPPPLDTGQARINNYHR---
MSMEG_2663|M.smegmatis_MC2_155 ACGCDNRLVGEAPNKWTTRIN-NHGQCEWIPPQLLDRGQHRTNTYHH---
MMAR_1523|M.marinum_M ACGPDHKLLEQG---WRTRKN-AHGDTEWLPPPHLDHGQPRTNTYHH---
MUL_2371|M.ulcerans_Agy99 ACGPDHKLLEQG---WRTRKN-AHGDTEWLPPPHLDHGQPRTNSYHH---
MAV_4180|M.avium_104 ACGPHHRLLQPGA--WTTHKN-ARGETQWLPPPHLDRNQPRTNTFHH---
MAB_0394c|M.abscessus_ATCC_199 ACGPHHRLLQQG---WTTRKRRSDGITEWIPPPHLDTGQSRTNDHHH---
TH_3287|M.thermoresistible__bu ACGPHHSGLTEG--RWQATIT-PTGRLAWTN----DHHPPTVNHAHH---
**. .: * : * * *
Rv1587c|M.tuberculosis_H37Rv CCCLPPNLRRPLRR------------------TARRGPPTRGLPKAVRAA
Mb1613c|M.bovis_AF2122/97 CCCLPPNLRRPLRR------------------TARRGPPTRGLPKAVRAA
Mflv_1835|M.gilvum_PYR-GCK ----PERLLRP---------------------------------------
Mvan_4827|M.vanbaalenii_PYR-1 ----PERLLRPP--------------------------------------
MSMEG_2663|M.smegmatis_MC2_155 ----PETLLADIKSGFTDDTADSRSQTSKTTGSETHAKQAADTEPDTAIA
MMAR_1523|M.marinum_M ----PEKLLR----------------------------------------
MUL_2371|M.ulcerans_Agy99 ----PEKLLR----------------------------------------
MAV_4180|M.avium_104 ----PEKLLRGE--------------------------------------
MAB_0394c|M.abscessus_ATCC_199 ----PERFIRRF--------------------------------------
TH_3287|M.thermoresistible__bu ----PEELLRAHTD------------------------------------
* :
Rv1587c|M.tuberculosis_H37Rv KMGARRVPRQRRQRINRQAPPRLRADVGRHHRRQDRRRGGLGPGPAPSP-
Mb1613c|M.bovis_AF2122/97 KMGARRVPRQRRQRINRQAPPRLRADVGRHHRRQDRRRGGLGPGPAPSP-
Mflv_1835|M.gilvum_PYR-GCK ----------EDPEPLGDN---------------DSQ----ASRPADDP-
Mvan_4827|M.vanbaalenii_PYR-1 ----------EEPEPHSDNDIAATAKPAEGNEIGDAQP--GAPHPADNP-
MSMEG_2663|M.smegmatis_MC2_155 RGNDLSDRPAIPPELLGQNHQQPNTNHHPDTERGDARNSGATGHNQDHSR
MMAR_1523|M.marinum_M -------------------------------------------DSAADE-
MUL_2371|M.ulcerans_Agy99 -------------------------------------------DSADDD-
MAV_4180|M.avium_104 -------------------------------------------DGGEDD-
MAB_0394c|M.abscessus_ATCC_199 --------------------------------------------------
TH_3287|M.thermoresistible__bu --------------------------------------------PPEDPG
Rv1587c|M.tuberculosis_H37Rv --------SHRAGSLHVISRREAAGPGHRRRRR
Mb1613c|M.bovis_AF2122/97 --------SHRAGSLHVISRREAAGPGHRRRRR
Mflv_1835|M.gilvum_PYR-GCK ------------GEPGGPAPPEGEAA-------
Mvan_4827|M.vanbaalenii_PYR-1 ------------GEPGGPAPPDNQAA-------
MSMEG_2663|M.smegmatis_MC2_155 KNGDRNSGDASKGNNGNADGDDGESDCHPA---
MMAR_1523|M.marinum_M ------------------GEEGG----------
MUL_2371|M.ulcerans_Agy99 ------------------DEGHGAA--------
MAV_4180|M.avium_104 ------------------DGDDDEAA-------
MAB_0394c|M.abscessus_ATCC_199 ---------------------------------
TH_3287|M.thermoresistible__bu ---------------------------------