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VLAKLAAPGATNPDDHTPVIDTTPDAAAIDRDTRSQAQRNHDGLLAGLRALIASGELGQHNGLPVSIVVT TTLTDLQTGAGKGFTGGGTLLPMADVIRMTSHAHHYSPASGRYPQAIFDHGTPLALYHTKRLASPAQRIM LFANDRGCTKPGCDAPAYHSQAHHVTGWTSTGRTDITDLTLACDPDNRLAEKGWTTRKNTHGHTEWLPPP HLDHGQPWTCEIHYTCACCCLPPNLRRPLRRTARRGPPTRGLPKAVRAAKMGARRVPRQRRQRINRQAPP RLRADVGRHHRRQDRRRGGLGPGPAPSPSHRAGSLHVISRREAAGPGHRRRRR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1613c | - | - | 100% (333) | REP13E12 repeat-containing protein |
| M. bovis AF2122 / 97 | Mb0097c | - | e-133 | 98.21% (224) | hypothetical protein Mb0097c |
| M. bovis AF2122 / 97 | Mb3496 | - | e-131 | 97.32% (224) | hypothetical protein Mb3496 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_1835 | - | 7e-59 | 53.64% (220) | hypothetical protein Mflv_1835 |
| M. tuberculosis H37Rv | Rv1587c | - | 0.0 | 98.20% (333) | REP13E12 repeat-containing protein |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0394c | - | 8e-67 | 53.78% (225) | hypothetical protein MAB_0394c |
| M. marinum M | MMAR_1523 | - | 3e-82 | 61.16% (224) | hypothetical protein MMAR_1523 |
| M. avium 104 | MAV_4180 | - | 7e-84 | 65.78% (225) | hypothetical protein MAV_4180 |
| M. smegmatis MC2 155 | MSMEG_2663 | - | 6e-52 | 47.14% (227) | hypothetical protein MSMEG_2663 |
| M. thermoresistible (build 8) | TH_3287 | - | 6e-34 | 40.50% (200) | PUTATIVE conserved hypothetical protein |
| M. ulcerans Agy99 | MUL_2371 | - | 2e-81 | 61.16% (224) | hypothetical protein MUL_2371 |
| M. vanbaalenii PYR-1 | Mvan_5865 | - | 3e-61 | 54.30% (221) | hypothetical protein Mvan_5865 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1613c|M.bovis_AF2122/97 --------------------------------------------------
Rv1587c|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_1835|M.gilvum_PYR-GCK ----MYVRVMSGGDLQTRIAVLRAAFDEVAACEIELLTRPDLVAALDELE
Mvan_5865|M.vanbaalenii_PYR-1 ----MYVRVMSRDALHAAVTALRATVDEVAACEADLCTRTELVAALDELE
MSMEG_2663|M.smegmatis_MC2_155 -MIRTSVRYMA-AEVGTALAALHAAMRDVLALPYTALSDADLLDVCAGIQ
MMAR_1523|M.marinum_M ---MSS---MSREEVVAAFDALDAVMARLQDLCFDGLTTPERLALLQRCE
MUL_2371|M.ulcerans_Agy99 ---MHSNGCSDRESVVATLDRLDRAVDALVEVSFEALTTPERLRVLERLE
MAV_4180|M.avium_104 ---MSS----DREAVSAAFDVIDAALDDLLDCDYAVLATREKLALLNRCE
MAB_0394c|M.abscessus_ATCC_199 ---------------MSPIDDLLTTATAVVESSFDELNNPELLSALRQLE
TH_3287|M.thermoresistible__bu MGQQFVTAGAARARVGELLAAVDAAYAEMRALCLDEVGTGFRLELAERLE
Mb1613c|M.bovis_AF2122/97 --------------------------------------------------
Rv1587c|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_1835|M.gilvum_PYR-GCK ELSCQLPAVGHRLLARLQAEGTPQQMGAKNWSEVLRVRWRISGSEAHRRL
Mvan_5865|M.vanbaalenii_PYR-1 TVGCRLPALSYRLLARLQAETTPPQMGAKSWKEVLAVRWRISTSEAHRRL
MSMEG_2663|M.smegmatis_MC2_155 DVRNLAPAVEHRAIAALSEQTTPAAIGAKSWPLVLATRLGISSKEARRRC
MMAR_1523|M.marinum_M VARRRLPSIEHPLINQLVEQAGEQELGGK-LAAVLAGRLRVSRGEASRRL
MUL_2371|M.ulcerans_Agy99 VVARRLPAAQYALVNQLDEQPGEAELGGR-LAAVVASRLRITRSEAGRRV
MAV_4180|M.avium_104 KLRRRLPAVEHPLINALARDASPAELGGR-LSHAIAEATLISRAEAARRV
MAB_0394c|M.abscessus_ATCC_199 IAQRKITAASHTLTARLVQRGSPVALGGTSFAEVLARYLSITTATARRRL
TH_3287|M.thermoresistible__bu TQCRINRGLMYRVFAQLADPPDEPAMVPAVRDRLWAR-LRITPGEVKRRL
Mb1613c|M.bovis_AF2122/97 --------------------------------------------------
Rv1587c|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_1835|M.gilvum_PYR-GCK TEAALLAPRPSLTGPALPPQLAATAIAQARGLINAEHVAVIRKAVKKLPG
Mvan_5865|M.vanbaalenii_PYR-1 TEAAVLAPRQAMTGEALAPVLPATATAQAHGLINAEHVEVIRKTMAKVPG
MSMEG_2663|M.smegmatis_MC2_155 ADAAELGPRVSLTGEALAPKREHIAAAQADGALTPDHVTELFKFFTKCPD
MMAR_1523|M.marinum_M REAADLGPRRALTGEQLAPLLSATASAVRQGRIGAGHVRVIREFCGQVPA
MUL_2371|M.ulcerans_Agy99 AEAAEVGPRRALSGQPVGPVLTATAAALRQGVVGEGHVRVIRDFFRQLPA
MAV_4180|M.avium_104 HTAADLGPRVGLTGEPLPPVLAATAAAQRAGSLGPEQVAVIRKFCHQLPG
MAB_0394c|M.abscessus_ATCC_199 ADAAHLGPRRALTGEPLRPALPYVAHALREGRLGDEHVRIIRRFFDVLPD
TH_3287|M.thermoresistible__bu RVAALLRPRRRLSGPPLPPVLARVAGAVESGLLGEEHLRVITTVMAALPS
Mb1613c|M.bovis_AF2122/97 --------------------------------------------------
Rv1587c|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_1835|M.gilvum_PYR-GCK WVDVATREQFEVNLVRTAVGHGPKELNDAADRMLFLLDQDGPEPDDAERG
Mvan_5865|M.vanbaalenii_PYR-1 FVDTATRERIEVDLVRTAVGNGPKELKDSADRTLFLLDQDGPEPDERERA
MSMEG_2663|M.smegmatis_MC2_155 WVTYAEQCRLEEKLVTGAIGADPETVRQAVDHAVFLLDQDGPAPTDNPPT
MMAR_1523|M.marinum_M EVDLETRERAEAHLARLAGQFRPDQLAKLAQRLMDCVNPDGRYSDE-DRA
MUL_2371|M.ulcerans_Agy99 GVDVGTRDRAEAHLAKLATQFRPDQLARLAGRLMDCLNPDGRHSDE-DRA
MAV_4180|M.avium_104 WIDQATRERAETDLAREGTRYRPEQLAALAGTLADCLNPDGLYRDE-DRA
MAB_0394c|M.abscessus_ATCC_199 AVDADTREAAEKQLASMGTEFGPEQLRAGADRIAALVNPDGR-FSDIDRA
TH_3287|M.thermoresistible__bu AVSVTDREAVEASLIAEAARSDAGIVRQVGRRIEEIFNPDGHYDDQ-DRA
Mb1613c|M.bovis_AF2122/97 --------------------------------MLAKLAAP----------
Rv1587c|M.tuberculosis_H37Rv --------------------------------MLAKLAAP----------
Mflv_1835|M.gilvum_PYR-GCK RKRGVSIGRQGAEAMSALTGQLTPEARAVWEAIFAKYAAP----------
Mvan_5865|M.vanbaalenii_PYR-1 RKRAVTKHKQREDGMVDVSATLTPEAWAVWEAIFAKFAAP----------
MSMEG_2663|M.smegmatis_MC2_155 KPFGITFGPQQPDGSYHLRGKVSAEFKATFDPIDEKLAAP----------
MMAR_1523|M.marinum_M RRRGLTLGRQGRDGMSRISGWLTPEARAGLDAVLAKLAAP----------
MUL_2371|M.ulcerans_Agy99 RRRGLSLGRQGLDGMSRISGWLTPEARAGLEAVWAKLAAP----------
MAV_4180|M.avium_104 RRRSLTLGNQHADGMSELRGLLTPELRATLEAVLAKLAAP----------
MAB_0394c|M.abscessus_ATCC_199 RRRGISIGRQGADGMSALSGLLDPETRAYFDAVLSKLAAP----------
TH_3287|M.thermoresistible__bu RRRGIHLGDQQRDGMSAISGWIDPQLRAYLEAVTAAVRPGRHLPHTTTDT
: .
Mb1613c|M.bovis_AF2122/97 ----------GATNPDDHTPVIDTTPDAAAIDRDT-----RSQAQRNHDG
Rv1587c|M.tuberculosis_H37Rv ----------GATNPDDHTPVIDTTPDAAAIDRDT-----RSQAQRNHDG
Mflv_1835|M.gilvum_PYR-GCK ----------GMCNPDDEQPCTSGTPSQAQIDGDH-----RSLAQRQHDA
Mvan_5865|M.vanbaalenii_PYR-1 ----------GMCNPDDPEPCTSGTPSQAQIDHDQ-----RSLAQRQHDA
MSMEG_2663|M.smegmatis_MC2_155 ----------GMCNPTDQTPCISGTPSQQQIDHDE-----RGAPERRHDA
MMAR_1523|M.marinum_M ----------GMCNPDDESPVVQAPAGADAVSRDR-----RSVGQRHHDG
MUL_2371|M.ulcerans_Agy99 ----------GMCNPEDEAAVVDGPVSRDAADRDS-----RSVSQRQHDG
MAV_4180|M.avium_104 ----------GMCNPLDESPCVDGTPTEQAIEGDT-----RSAAQRNHDG
MAB_0394c|M.abscessus_ATCC_199 ----------GMCDPRDESPMTEGEPDSAAAERDT-----RTSAQRNHDG
TH_3287|M.thermoresistible__bu TGTTGTTETTGTAGTAGTAATAADTAADGVGDIDTGGVDLRSAAQRRHDG
* .. . . . * * :*.**.
Mb1613c|M.bovis_AF2122/97 LLAGLRALIASGELGQHNGLPVSIVVTTTLTDLQTGA-----------GK
Rv1587c|M.tuberculosis_H37Rv LLAGLRALIASGKLGQHNGLPVSIVVTTTLTDLQTGA-----------GK
Mflv_1835|M.gilvum_PYR-GCK LLAVGRIALMSGELGQLNGLPVSVIIRTTLQDLESRA-----------GI
Mvan_5865|M.vanbaalenii_PYR-1 LLAGGRIALMSGQLGQLNGLPVSVIIRTTLQDLESRA-----------GV
MSMEG_2663|M.smegmatis_MC2_155 MLTAMRLLLAHKDLGQINGLPATLLITTTLQELEKAA-----------GV
MMAR_1523|M.marinum_M LNAAVRALLASGDLGQHNGLPASIIVTTTLGELQRAC-----------GR
MUL_2371|M.ulcerans_Agy99 FNAALRAVLASGELGQHNGLPASIIVSTTLKELEAAA-----------GR
MAV_4180|M.avium_104 LLAGLRALLASGNLGQHNGLPASIIVTTTLADLQAAA-----------GK
MAB_0394c|M.abscessus_ATCC_199 LRACLRSTLASGKLGAHRGLPVTVVVSTTLRELQSAA-----------GR
TH_3287|M.thermoresistible__bu LTLGLKIAVASGRLGSHRGHPVTVIVRTTLGELNQAAHAVADPRVSMPGP
: : : ** .* *.:::: *** :*: . *
Mb1613c|M.bovis_AF2122/97 GFTGGGTLLPMADVIRMTSHAHHYSPASGRYPQAIFDHGTPLALYHTKRL
Rv1587c|M.tuberculosis_H37Rv GFTGGGTLLPMADVIRMTSHAHHYSPASGRYPQAIFDHGTPLALYHTKRL
Mflv_1835|M.gilvum_PYR-GCK GVSGGGTKLPIRDVIRMAGHANHYLAVFDRA------TGSALDLFRTRRV
Mvan_5865|M.vanbaalenii_PYR-1 GVTGGGTVMPIAEVIRMAGHANHYLAVFDRA------TGSALDLFRTRRI
MSMEG_2663|M.smegmatis_MC2_155 AITAGGTKLSIPDLIRLASQALHYLAVYDEH------TGVPLYLGRARRT
MMAR_1523|M.marinum_M GLTGGGTVLPISDVIRLARHAHHYLAVFDRG--------KAVGLYHAKRL
MUL_2371|M.ulcerans_Agy99 GLTGGGTLLPMSDVIRLARHAHHYLAVFDRG--------EAIGLYHAKRL
MAV_4180|M.avium_104 GLTGGGTLLPMSDVIRLSRHAHHYLAIFDHG--------KALALYHTKRL
MAB_0394c|M.abscessus_ATCC_199 AISGSGNLVPIPDLIRMATHAFHYLTIFGDD-------GRPLHLGRSKRI
TH_3287|M.thermoresistible__bu ARTGGTGVLPMRELIRMAADAIHYLAVFDDH------TERPLYLGRQKRI
. :.. :.: ::**:: .* ** . . .: * : :*
Mb1613c|M.bovis_AF2122/97 ASPAQRIMLFANDRGCTKPGCDAPAYHSQAHHVTG-WTSTGRTDITDLTL
Rv1587c|M.tuberculosis_H37Rv ASPAQRIMLFANDRGCTKPGCDAPAYHSQAHHVTA-WTSTGRTDITELTL
Mflv_1835|M.gilvum_PYR-GCK ASPAQRVMLIARDGGCTKPCCTVGAYGCQVHHAEADYAHGGNTNIDELGL
Mvan_5865|M.vanbaalenii_PYR-1 ASPAQRIMLIARDGGCTKPGCAVGAYGCQGHHVEADFAKGGNTNVDELGL
MSMEG_2663|M.smegmatis_MC2_155 ASAGQRLAIWARDRGCTRPGCTANGYRCQAHHATTDYAKGGLTDADALAL
MMAR_1523|M.marinum_M ATAGQRLVLYAKDRGCTRPGCDVPGYQCEVHHVAA-WATSGRTDIDQLTL
MUL_2371|M.ulcerans_Agy99 ATPGQRIVLYAKDRGCTRPGCDVAGYQCEVHHVAA-WAISGRTDINQLTL
MAV_4180|M.avium_104 ASPAQRIVLYAKDRGCTAPGCTVPGYYAEVHHCTD-YATCHTTDINDLTF
MAB_0394c|M.abscessus_ATCC_199 ATPDQRIVLHAKDRGCSAPGCTVPGYLCQVHHVDD-WRDDGPTDIDNLTF
TH_3287|M.thermoresistible__bu ATADQRLICYARDGGCTAPGCGEPGYHAETHHQPA-WEDGGLTDADHLFF
*:. **: *.* **: * * .* .: ** : *: * :
Mb1613c|M.bovis_AF2122/97 ACDPDNRLAEKG---WTTRKN-THGHTEWLPPPHLDHGQPWTCEIHYTCA
Rv1587c|M.tuberculosis_H37Rv ACGPDNRLAEKG---WTTHNN-THGHTEWLPPPHLDHGQPWTCEIHYTCA
Mflv_1835|M.gilvum_PYR-GCK ACGPDNRSVTD--GGWTTRMN-DRCEVEWIPPPGLDTGQARVNTYHR---
Mvan_5865|M.vanbaalenii_PYR-1 ACGPDNRDVNDR-GGWTTRMN-DRCEVEWIPPPALDTGQARVNNYHR---
MSMEG_2663|M.smegmatis_MC2_155 ACGCDNRLVGEAPNKWTTRIN-NHGQCEWIPPQLLDRGQHRTNTYHH---
MMAR_1523|M.marinum_M ACGPDHKLLEQG---WRTRKN-AHGDTEWLPPPHLDHGQPRTNTYHH---
MUL_2371|M.ulcerans_Agy99 ACGPDHKLLEQG---WRTRKN-AHGDTEWLPPPHLDHGQPRTNSYHH---
MAV_4180|M.avium_104 ACGPHHRLLQPGA--WTTHKN-ARGETQWLPPPHLDRNQPRTNTFHH---
MAB_0394c|M.abscessus_ATCC_199 ACGPHHRLLQQG---WTTRKRRSDGITEWIPPPHLDTGQSRTNDHHH---
TH_3287|M.thermoresistible__bu ACGPHHSGLTEG--RWQATIT-PTGRLAWTN----DHHPPTVNHAHH---
**. .: * : * * . *
Mb1613c|M.bovis_AF2122/97 CCCLPPNLRRPLRR--------TARRGPPTRGLPKAVRAAKMGARRVPRQ
Rv1587c|M.tuberculosis_H37Rv CCCLPPNLRRPLRR--------TARRGPPTRGLPKAVRAAKMGARRVPRQ
Mflv_1835|M.gilvum_PYR-GCK ----PERLLRP--------------EDPEPLGDN----------------
Mvan_5865|M.vanbaalenii_PYR-1 ----PERLLRPP-------------DDPEPPGDNTIAAEAASAGTDQADP
MSMEG_2663|M.smegmatis_MC2_155 ----PETLLADIKSGFTDDTADSRSQTSKTTGSETHAKQAADTEPDTAIA
MMAR_1523|M.marinum_M ----PEKLLR----------------------------------------
MUL_2371|M.ulcerans_Agy99 ----PEKLLR----------------------------------------
MAV_4180|M.avium_104 ----PEKLLRGE--------------------------------------
MAB_0394c|M.abscessus_ATCC_199 ----PERFIRRF--------------------------------------
TH_3287|M.thermoresistible__bu ----PEELLR----------------------------------------
* :
Mb1613c|M.bovis_AF2122/97 RRQRINRQAPPRLRADVGRHHRRQDRRRGGLGPGPAPSPSHRAGSLHVIS
Rv1587c|M.tuberculosis_H37Rv RRQRINRQAPPRLRADVGRHHRRQDRRRGGLGPGPAPSPSHRAGSLHVIS
Mflv_1835|M.gilvum_PYR-GCK ------------------DSQASRPADDPGEPGGPAPPEGEAA-------
Mvan_5865|M.vanbaalenii_PYR-1 RGD--------------AESDAPQPTDDPGEPGGPAPPGDQAA-------
MSMEG_2663|M.smegmatis_MC2_155 RGNDLSDRPAIPPELLGQNHQQPNTNHHPDTERGDARNSGATGHNQDHSR
MMAR_1523|M.marinum_M -----------------------DSAADEGEEGG----------------
MUL_2371|M.ulcerans_Agy99 -----------------------DSADDDDEGHGAA--------------
MAV_4180|M.avium_104 -----------------------DGGEDDDGDDDEAA-------------
MAB_0394c|M.abscessus_ATCC_199 --------------------------------------------------
TH_3287|M.thermoresistible__bu ------------------------AHTDPPEDPG----------------
Mb1613c|M.bovis_AF2122/97 RREAAGPGHRRRRR----------------
Rv1587c|M.tuberculosis_H37Rv RREAAGPGHRRRRR----------------
Mflv_1835|M.gilvum_PYR-GCK ------------------------------
Mvan_5865|M.vanbaalenii_PYR-1 ------------------------------
MSMEG_2663|M.smegmatis_MC2_155 KNGDRNSGDASKGNNGNADGDDGESDCHPA
MMAR_1523|M.marinum_M ------------------------------
MUL_2371|M.ulcerans_Agy99 ------------------------------
MAV_4180|M.avium_104 ------------------------------
MAB_0394c|M.abscessus_ATCC_199 ------------------------------
TH_3287|M.thermoresistible__bu ------------------------------