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GKERTKTVDRTRVTPVAVIGMGCRLPGGIDSPDRLWEALLRGDDLVTEIPADRWDIDEYYDPEPGVPGRT DCKWGAYLDNVGDFDPEFFGIGEKEAIAIDPQHRLLLETSWEAMEHGGLTPNQMASRTGVFVGLVHTDYI LVHADNQTFEGPYGNTGTNACFASGRVAYAMGLQGPAITVDTACSSGLTAIHLACRSLHDGESDIALAGG VYVMLEPRRFASGSALGMLSATGRCHAFDVSADGFVSGEGCVMLALKRLPDALADGDRILAVIRGTAANQ DGHTVNIATPSRSAQVAAYREALDVAGVDPATVGMVEAHGPGTPVGDPIEYASLAEVYGNDGPCALASVK TNFGHTQSAAGALGLMKAVLALQHGVVPQNLHFTALPDKLAAIETNLFVPQEITPWPGADQETPRRAAVS SYGMTGTNVHAIVEQAPVPAPESGAPGDTPATPGIDGALLFALSASSQDALRQTAARLADWVDAQGPELA PADLAYTLARRRGHRPVRTAVLAATTAELTEALREVATGEPPYPPAVGQDDRGPVWVFSGQGSQWAGMGA DLLATEPVFAATIAAIEPLIAAESGFSVTEAMTAPEVVTGIDRVQPTLFAMQVALAATMKSYGVAPGAVI GHSLGESAAAVVAGALCLEDGVRVICRRSALMTRIAGAGAMASVELPAQQVLSELMARGVNDAVVAVVAS PQSTVIGGATQTVRDLVAAWEQRDVLAREVAVDVASHSPQVDPILDELAEALAEISPLQPEIPYYSATSF DPREEPYCDAYYWVDNLRHTVRFAAAVQAALEDGYRVFTELTPHPLLTHAVDQTARSLDMSAAALAGMRR EQPLPHGLRALAGDLYAAGAAVDFAVLYPTGRLINAPLPTWNHRRLLLDDTTRRIAHANTVAVHPLLGSH VRLPEEPERHVWQGEVGTVTQPWLADHQIHGAAALPGAAYCEMALAAARAVLGEASEVRDIRFEQMLLLD DETPIGVTATVEAPGVVPLTVETSHDGRYTRQLAAVLHVVREADDAPDQPPQKNIAELLASHPHKVDGAE VRQWLDKRGHRLGPAFAGLVDAYIAEGAGDTVLAEVNLPGPLRSQVKAYGVHPVLLDACFQSVAAHPAVQ GMADGGLLLPLGVRRLRSYGSARHARYCCTTVTACGVGVEADLDVLDEHGAVVLAVRGLQLGTGASQASE RARVLGERLLSIEWHERELPENSHAEPGAWLLISTCDATDLVAAQLTDALKVHDAQCTTMSWPQRADHAA QAARLRDQLGTGGFTGVFVLTAPQTGDPDAESPVRGGELVKHVVRIAREIPEITAQEPRLYVLTHNAQAV LSGDRPNLEQGGMRGLLRVIGAEHPHLKASYVDVDEQTGAESVARQLLAASGEDETAWRNDQWYTARLCP APLRPEERQTTVVDHAEAGMRLQIRTPGDLQTLEFAAFDRVPPGPGEIEVAVTASSINFADVLVTFGRYQ TLDGRQPQLGTDFAGVVSAVGPGVSELKVGDRVGGMSPNGCWATFVTCDARLATRLPEGLTDAQAAAVTT ASATAWYGLQDLARIKAGDKVLIHSATGGVGQAAIAIARAAGAQIYATAGNEKRRDLLRDMGIEHVYDSR SVEFAEQIRRDTAGYGVDIVLNSVTGAAQLAGLKLLALGGRFIEIGKRDIYSNTRLELLPFRRNLAFYGL DLGLMSVSHPAAVRELLSTVYRLTVEGVLPMPQSTHYPLAEAATAIRVMGAAEHTGKLILDVPHAGRSSV VLPPEQARVFRSDGSYIITGGLGGLGLFLAEKMANAGAGRIVLSSRSQPSQKALETIELVRAIGSDVVVE CGDIAQPDTADRLVTAATATGLPLRGVLHAAAVVEDATLANITDELIERDWAPKAYGAWQLHRATADQPL DWFCSFSSAAALVGSPGQGAYAAANSWLDTFTHWRRAQDLPATSIAWGAWGQIGRAIAFAEQTGDAIAPE EGAYAFETLLRHNRAYSGYAPVIGSPWLTAFAQHSPFAEKFQSLGQNRSGTSKFLAELVDLPREEWPDRL RRLLSKQVGLILRRTIDTDRLLSEYGLDSLSSQELRARVEAETGIRISATEINTTVRGLADLMCDKLAAD RDAPAPA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv1527c | pks5 | - | 100% (2108) | Probable polyketide synthase pks5 |
| M. tuberculosis H37Rv | Rv3825c | pks2 | 0.0 | 69.91% (2117) | polyketide synthase PKS2 |
| M. tuberculosis H37Rv | Rv2940c | mas | 0.0 | 65.87% (2121) | multifunctional mycocerosic acid synthase membrane-associated |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1554c | pks5 | 0.0 | 99.91% (2108) | polyketide synthase pks5 |
| M. gilvum PYR-GCK | Mflv_0405 | - | 0.0 | 33.63% (2171) | beta-ketoacyl synthase |
| M. leprae Br4923 | MLBr_00139 | mas | 0.0 | 63.83% (2112) | putative mycocerosic synthase |
| M. abscessus ATCC 19977 | MAB_3148c | - | 0.0 | 62.04% (2084) | polyketide synthase Pks5 |
| M. marinum M | MMAR_2340 | pks5 | 0.0 | 73.38% (2096) | polyketide synthase Pks5 |
| M. avium 104 | MAV_2370 | - | 0.0 | 70.13% (2099) | mycocerosic acid synthase |
| M. smegmatis MC2 155 | MSMEG_4727 | - | 0.0 | 65.34% (2118) | mycocerosic acid synthase |
| M. thermoresistible (build 8) | TH_4621 | - | 0.0 | 69.30% (1821) | PUTATIVE mycocerosic acid synthase |
| M. ulcerans Agy99 | MUL_2010 | mas | 0.0 | 66.48% (2103) | multifunctional mycocerosic acid synthase membrane-associated |
| M. vanbaalenii PYR-1 | Mvan_0269 | - | 0.0 | 34.03% (2166) | beta-ketoacyl synthase |
CLUSTAL 2.0.9 multiple sequence alignment
Rv1527c|M.tuberculosis_H37Rv --------------------------------------------------
Mb1554c|M.bovis_AF2122/97 --------------------------------------------------
MMAR_2340|M.marinum_M --------------------------------------------------
MAV_2370|M.avium_104 --------------------------------------------------
MLBr_00139|M.leprae_Br4923 --------------------------------------------------
MUL_2010|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_4727|M.smegmatis_MC2_155 --------------------------------------------------
MAB_3148c|M.abscessus_ATCC_199 --------------------------------------------------
TH_4621|M.thermoresistible__bu --------------------------------------------------
Mflv_0405|M.gilvum_PYR-GCK MGSAAHQGESAHRFAIVGYAGRFPGARDAESFWELLADGRDAISEVPEDR
Mvan_0269|M.vanbaalenii_PYR-1 MGSAEHPNGPAPRFAIVGYAARFPGAPDADAFWDVLREGRDAISDVPRDR
Rv1527c|M.tuberculosis_H37Rv --------------------------------------------------
Mb1554c|M.bovis_AF2122/97 --------------------------------------------------
MMAR_2340|M.marinum_M --------------------------------------------------
MAV_2370|M.avium_104 --------------------------------------------------
MLBr_00139|M.leprae_Br4923 --------------------------------------------------
MUL_2010|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_4727|M.smegmatis_MC2_155 --------------------------------------------------
MAB_3148c|M.abscessus_ATCC_199 --------------------------------------------------
TH_4621|M.thermoresistible__bu --------------------------------------------------
Mflv_0405|M.gilvum_PYR-GCK WDVEAFFDPDPSTPGKVVTRRAGFVDDVSGFDAPFFGMSTREVRLMDPQH
Mvan_0269|M.vanbaalenii_PYR-1 WDAEEFFDPEPGAPGKVVTRRAGFVDDVTGFDAPFFGMSTREVRMMDPQH
Rv1527c|M.tuberculosis_H37Rv --------------------------------------------------
Mb1554c|M.bovis_AF2122/97 --------------------------------------------------
MMAR_2340|M.marinum_M --------------------------------------------------
MAV_2370|M.avium_104 --------------------------------------------------
MLBr_00139|M.leprae_Br4923 --------------------------------------------------
MUL_2010|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_4727|M.smegmatis_MC2_155 --------------------------------------------------
MAB_3148c|M.abscessus_ATCC_199 --------------------------------------------------
TH_4621|M.thermoresistible__bu --------------------------------------------------
Mflv_0405|M.gilvum_PYR-GCK RLLLETAWRAIEHSGTAPSELANTNTGVFVGLATHDYLGMASDELSYPEI
Mvan_0269|M.vanbaalenii_PYR-1 RLLLETAWRAVEHSGTAPTALAGSNTGVFVGLATHDYLGMASDELTYPEI
Rv1527c|M.tuberculosis_H37Rv --------------------------------------------------
Mb1554c|M.bovis_AF2122/97 --------------------------------------------------
MMAR_2340|M.marinum_M --------------------------------------------------
MAV_2370|M.avium_104 --------------------------------------------------
MLBr_00139|M.leprae_Br4923 --------------------------------------------------
MUL_2010|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_4727|M.smegmatis_MC2_155 --------------------------------------------------
MAB_3148c|M.abscessus_ATCC_199 --------------------------------------------------
TH_4621|M.thermoresistible__bu --------------------------------------------------
Mflv_0405|M.gilvum_PYR-GCK EAYMAIGTSNAAAAGRISYRLGLQGPAVAVDTACSSSLVAIHQACQALRL
Mvan_0269|M.vanbaalenii_PYR-1 EAYMAIGTSNAAAAGRISYRLGLQGPAVAVDTACSSSLVAIHQACQALRL
Rv1527c|M.tuberculosis_H37Rv --------------------------------------------------
Mb1554c|M.bovis_AF2122/97 --------------------------------------------------
MMAR_2340|M.marinum_M --------------------------------------------------
MAV_2370|M.avium_104 --------------------------------------------------
MLBr_00139|M.leprae_Br4923 --------------------------------------------------
MUL_2010|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_4727|M.smegmatis_MC2_155 --------------------------------------------------
MAB_3148c|M.abscessus_ATCC_199 --------------------------------------------------
TH_4621|M.thermoresistible__bu --------------------------------------------------
Mflv_0405|M.gilvum_PYR-GCK GECDLALAGGANVILTPATMITFSNAHMLAPDGRCKTFDAAADGYVRGEG
Mvan_0269|M.vanbaalenii_PYR-1 GECDLALAGGANVLLTPATMITFSNAHMLAPDGRCKTFDAAADGYVRGEG
Rv1527c|M.tuberculosis_H37Rv --------------------------------------------------
Mb1554c|M.bovis_AF2122/97 --------------------------------------------------
MMAR_2340|M.marinum_M --------------------------------------------------
MAV_2370|M.avium_104 --------------------------------------------------
MLBr_00139|M.leprae_Br4923 --------------------------------------------------
MUL_2010|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_4727|M.smegmatis_MC2_155 --------------------------------------------------
MAB_3148c|M.abscessus_ATCC_199 --------------------------------------------------
TH_4621|M.thermoresistible__bu --------------------------------------------------
Mflv_0405|M.gilvum_PYR-GCK CGVIVIKRLEDAVRDGDRIRAVIRGSAINQDGASGGLTVPNGVAQQRVIG
Mvan_0269|M.vanbaalenii_PYR-1 CGVIVIKRLEDAVRDGDRIRAVIRGSSINQDGASGGLTVPNGVAQQRVIA
Rv1527c|M.tuberculosis_H37Rv --------------------------------------------------
Mb1554c|M.bovis_AF2122/97 --------------------------------------------------
MMAR_2340|M.marinum_M --------------------------------------------------
MAV_2370|M.avium_104 --------------------------------------------------
MLBr_00139|M.leprae_Br4923 --------------------------------------------------
MUL_2010|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_4727|M.smegmatis_MC2_155 --------------------------------------------------
MAB_3148c|M.abscessus_ATCC_199 --------------------------------------------------
TH_4621|M.thermoresistible__bu --------------------------------------------------
Mflv_0405|M.gilvum_PYR-GCK DALSRAGLAPGDVDYLEAHGTGTSLGDPIEAQAAGAALGPGREPQRPLLI
Mvan_0269|M.vanbaalenii_PYR-1 DALKRSDLEPKDVGYLEAHGTGTSLGDPIEAQAAGAVLGAGREPSRPLLI
Rv1527c|M.tuberculosis_H37Rv --------------------------------------------------
Mb1554c|M.bovis_AF2122/97 --------------------------------------------------
MMAR_2340|M.marinum_M --------------------------------------------------
MAV_2370|M.avium_104 --------------------------------------------------
MLBr_00139|M.leprae_Br4923 --------------------------------------------------
MUL_2010|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_4727|M.smegmatis_MC2_155 --------------------------------------------------
MAB_3148c|M.abscessus_ATCC_199 --------------------------------------------------
TH_4621|M.thermoresistible__bu --------------------------------------------------
Mflv_0405|M.gilvum_PYR-GCK GSAKTNIGHLEAAAGIAGVIKVVLSLEHETLPKHLNFENPSPHIPWDRLP
Mvan_0269|M.vanbaalenii_PYR-1 GSAKTNIGHLEAAAGIAGVIKVILSLEHRTLPKHLNFENPSPHIPWDRLA
Rv1527c|M.tuberculosis_H37Rv --------------------------------------------------
Mb1554c|M.bovis_AF2122/97 --------------------------------------------------
MMAR_2340|M.marinum_M --------------------------------------------------
MAV_2370|M.avium_104 --------------------------------------------------
MLBr_00139|M.leprae_Br4923 --------------------------------------------------
MUL_2010|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_4727|M.smegmatis_MC2_155 --------------------------------------------------
MAB_3148c|M.abscessus_ATCC_199 --------------------------------------------------
TH_4621|M.thermoresistible__bu --------------------------------------------------
Mflv_0405|M.gilvum_PYR-GCK VEVVKESIPWRRGQRGGRPRIAGVSSFGFAGTNAHVILEEAP-LAAEPAQ
Mvan_0269|M.vanbaalenii_PYR-1 VEVVKETIPWER---DGGPRIAGVSSFGFAGTNAHVILEEAPEQAAAPGP
Rv1527c|M.tuberculosis_H37Rv --------------------------------------------------
Mb1554c|M.bovis_AF2122/97 --------------------------------------------------
MMAR_2340|M.marinum_M --------------------------------------------------
MAV_2370|M.avium_104 --------------------------------------------------
MLBr_00139|M.leprae_Br4923 --------------------------------------------------
MUL_2010|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_4727|M.smegmatis_MC2_155 --------------------------------------------------
MAB_3148c|M.abscessus_ATCC_199 --------------------------------------------------
TH_4621|M.thermoresistible__bu --------------------------------------------------
Mflv_0405|M.gilvum_PYR-GCK ESVDDGRFTLLPLSARTPAALMAVADRYRDWLVANPDATLADLCFTAGTA
Mvan_0269|M.vanbaalenii_PYR-1 VQQPDRRFSLLPLSARTPAALTQLAGQYRDWWTAHPEATLADVCFTAGAG
Rv1527c|M.tuberculosis_H37Rv --------------------------------------------------
Mb1554c|M.bovis_AF2122/97 --------------------------------------------------
MMAR_2340|M.marinum_M --------------------------------------------------
MAV_2370|M.avium_104 --------------------------------------------------
MLBr_00139|M.leprae_Br4923 --------------------------------------------------
MUL_2010|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_4727|M.smegmatis_MC2_155 --------------------------------------------------
MAB_3148c|M.abscessus_ATCC_199 --------------------------------------------------
TH_4621|M.thermoresistible__bu --------------------------------------------------
Mflv_0405|M.gilvum_PYR-GCK RSHLEHRAALVVNTREAALDLLGALADDRPAPGLVRGESHDTPKTAWLFT
Mvan_0269|M.vanbaalenii_PYR-1 RAHLEHRAALVVNSAESAVELLGALADDRPAPGLVRGESHDTPKTAWLFT
Rv1527c|M.tuberculosis_H37Rv --------------------------------------------------
Mb1554c|M.bovis_AF2122/97 --------------------------------------------------
MMAR_2340|M.marinum_M --------------------------------------------------
MAV_2370|M.avium_104 --------------------------------------------------
MLBr_00139|M.leprae_Br4923 --------------------------------------------------
MUL_2010|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_4727|M.smegmatis_MC2_155 --------------------------------------------------
MAB_3148c|M.abscessus_ATCC_199 --------------------------------------------------
TH_4621|M.thermoresistible__bu --------------------------------------------------
Mflv_0405|M.gilvum_PYR-GCK GQGSQYPGMSRELFDTEPLFAETLRECAAAVDGMLEKPLLDVIFDTDGVL
Mvan_0269|M.vanbaalenii_PYR-1 GQGSQYPGMARELYDTEPVFAETLNRCAEAVADVLEKPLLDVIFDAE---
Rv1527c|M.tuberculosis_H37Rv --------------------------------------------------
Mb1554c|M.bovis_AF2122/97 --------------------------------------------------
MMAR_2340|M.marinum_M --------------------------------------------------
MAV_2370|M.avium_104 --------------------------------------------------
MLBr_00139|M.leprae_Br4923 --------------------------------------------------
MUL_2010|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_4727|M.smegmatis_MC2_155 --------------------------------------------------
MAB_3148c|M.abscessus_ATCC_199 --------------------------------------------------
TH_4621|M.thermoresistible__bu --------------------------------------------------
Mflv_0405|M.gilvum_PYR-GCK DTDSNETLRHTSYAQPALFAVEMGLARLWQSWGFEPDVVLGHSVGQYAAA
Mvan_0269|M.vanbaalenii_PYR-1 ADDAEKTLQNTCYAQPALFAVEMGLARLWQSWGFEPDVVLGHSVGQYSAA
Rv1527c|M.tuberculosis_H37Rv --------------------------------------------------
Mb1554c|M.bovis_AF2122/97 --------------------------------------------------
MMAR_2340|M.marinum_M --------------------------------------------------
MAV_2370|M.avium_104 --------------------------------------------------
MLBr_00139|M.leprae_Br4923 --------------------------------------------------
MUL_2010|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_4727|M.smegmatis_MC2_155 --------------------------------------------------
MAB_3148c|M.abscessus_ATCC_199 --------------------------------------------------
TH_4621|M.thermoresistible__bu --------------------------------------------------
Mflv_0405|M.gilvum_PYR-GCK CVAGVLSLRDGARLMAERGRLFGSLPSGGRMAAVFAAAERVEALTDEYPA
Mvan_0269|M.vanbaalenii_PYR-1 CVAGVFSLTDGARLMAERGRLFGSLPEGGRMVAVFTTAERAEAMTDEFPS
Rv1527c|M.tuberculosis_H37Rv --------------------------------------------------
Mb1554c|M.bovis_AF2122/97 --------------------------------------------------
MMAR_2340|M.marinum_M --------------------------------------------------
MAV_2370|M.avium_104 --------------------------------------------------
MLBr_00139|M.leprae_Br4923 --------------------------------------------------
MUL_2010|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_4727|M.smegmatis_MC2_155 --------------------------------------------------
MAB_3148c|M.abscessus_ATCC_199 --------------------------------------------------
TH_4621|M.thermoresistible__bu --------------------------------------------------
Mflv_0405|M.gilvum_PYR-GCK LSVAAYNGANTVLSGPATDLERAVAGLVADGVRCDWLETSHAFHSALLDP
Mvan_0269|M.vanbaalenii_PYR-1 LSVAAYNGTNTVLSGPAGDLEKAVATLSADGVRCDWLDTSHAFHSALLDP
Rv1527c|M.tuberculosis_H37Rv --------------------------------------------------
Mb1554c|M.bovis_AF2122/97 --------------------------------------------------
MMAR_2340|M.marinum_M --------------------------------------------------
MAV_2370|M.avium_104 --------------------------------------------------
MLBr_00139|M.leprae_Br4923 --------------------------------------------------
MUL_2010|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_4727|M.smegmatis_MC2_155 --------------------------------------------------
MAB_3148c|M.abscessus_ATCC_199 --------------------------------------------------
TH_4621|M.thermoresistible__bu --------------------------------------------------
Mflv_0405|M.gilvum_PYR-GCK ILDDFESYARGITFTAPQRILIDNRTGAALGRSVTLDAAYWRRHARQPVE
Mvan_0269|M.vanbaalenii_PYR-1 ILDDFESYANQFDFAAPQRILIDNRTGTALGRSVQLDGTYWRRHARQPVE
Rv1527c|M.tuberculosis_H37Rv --------------------------------------------------
Mb1554c|M.bovis_AF2122/97 --------------------------------------------------
MMAR_2340|M.marinum_M --------------------------------------------------
MAV_2370|M.avium_104 --------------------------------------------------
MLBr_00139|M.leprae_Br4923 --------------------------------------------------
MUL_2010|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_4727|M.smegmatis_MC2_155 --------------------------------------------------
MAB_3148c|M.abscessus_ATCC_199 --------------------------------------------------
TH_4621|M.thermoresistible__bu --------------------------------------------------
Mflv_0405|M.gilvum_PYR-GCK FAKSVHTLADMNCKLLVEIGPRPVLTAAALSAWPDPATSPRVIASLRRTT
Mvan_0269|M.vanbaalenii_PYR-1 FAKSVRTLAEMNCKLLVEIGPRPVLTAAALGAWPDPATAPRVIASLRRTA
Rv1527c|M.tuberculosis_H37Rv --------------------------------------------------
Mb1554c|M.bovis_AF2122/97 --------------------------------------------------
MMAR_2340|M.marinum_M --------------------------------------------------
MAV_2370|M.avium_104 --------------------------------------------------
MLBr_00139|M.leprae_Br4923 --------------------------------------------------
MUL_2010|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_4727|M.smegmatis_MC2_155 --------------------------------------------------
MAB_3148c|M.abscessus_ATCC_199 --------------------------------------------------
TH_4621|M.thermoresistible__bu --------------------------------------------------
Mflv_0405|M.gilvum_PYR-GCK ADQRQITEAVADAYVLGHLPRFAAFRRDGARVLDLPTYPFEHRQYWFSDS
Mvan_0269|M.vanbaalenii_PYR-1 ADHRQITEAVADAYVLGHLPEFGAFRDAGARKLDLPTYPFEHRQYWFRDN
Rv1527c|M.tuberculosis_H37Rv --------------------------------------------------
Mb1554c|M.bovis_AF2122/97 --------------------------------------------------
MMAR_2340|M.marinum_M --------------------------------------------------
MAV_2370|M.avium_104 --------------------------------------------------
MLBr_00139|M.leprae_Br4923 --------------------------------------------------
MUL_2010|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_4727|M.smegmatis_MC2_155 --------------------------------------------------
MAB_3148c|M.abscessus_ATCC_199 --------------------------------------------------
TH_4621|M.thermoresistible__bu --------------------------------------------------
Mflv_0405|M.gilvum_PYR-GCK REP--VAAAPQRGARTETVRLLEDGRIEELAALLGGTVDDPFTFDVLNRL
Mvan_0269|M.vanbaalenii_PYR-1 QDPDGSEALQPRTPSTEAVRLLEDGRIEELATLLDGAAGDQQTLDVLSRL
Rv1527c|M.tuberculosis_H37Rv --------------------------------------------------
Mb1554c|M.bovis_AF2122/97 --------------------------------------------------
MMAR_2340|M.marinum_M --------------------------------------------------
MAV_2370|M.avium_104 --------------------------------------------------
MLBr_00139|M.leprae_Br4923 --------------------------------------------------
MUL_2010|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_4727|M.smegmatis_MC2_155 --------------------------------------------------
MAB_3148c|M.abscessus_ATCC_199 --------------------------------------------------
TH_4621|M.thermoresistible__bu --------------------------------------------------
Mflv_0405|M.gilvum_PYR-GCK AAQHNQQRSTESIADDRYQIRWETAAEPPVGADAADGITWLLVGDDTDAT
Mvan_0269|M.vanbaalenii_PYR-1 AAQHNQQRSSQSITNDRYEIRWEQSAAALSGAETDEVSSWILVGDDTEAT
Rv1527c|M.tuberculosis_H37Rv --------------------------------------------------
Mb1554c|M.bovis_AF2122/97 --------------------------------------------------
MMAR_2340|M.marinum_M --------------------------------------------------
MAV_2370|M.avium_104 --------------------------------------------------
MLBr_00139|M.leprae_Br4923 --------------------------------------------------
MUL_2010|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_4727|M.smegmatis_MC2_155 --------------------------------------------------
MAB_3148c|M.abscessus_ATCC_199 --------------------------------------------------
TH_4621|M.thermoresistible__bu --------------------------------------------------
Mflv_0405|M.gilvum_PYR-GCK RPLVDVLAARGHRYRILGLPKSGAEEHELADTLRDAAADATDLRIVHVAA
Mvan_0269|M.vanbaalenii_PYR-1 RPLVDVLSARGQRYRIFGLPVSDADEEQLGEALRLAAAEDSTLRIVHVGG
Rv1527c|M.tuberculosis_H37Rv --------------------------------------------------
Mb1554c|M.bovis_AF2122/97 --------------------------------------------------
MMAR_2340|M.marinum_M --------------------------------------------------
MAV_2370|M.avium_104 --------------------------------------------------
MLBr_00139|M.leprae_Br4923 --------------------------------------------------
MUL_2010|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_4727|M.smegmatis_MC2_155 --------------------------------------------------
MAB_3148c|M.abscessus_ATCC_199 --------------------------------------------------
TH_4621|M.thermoresistible__bu --------------------------------------------------
Mflv_0405|M.gilvum_PYR-GCK LDAAES---DTSMKSLLRMQHRVLGGTRRLFGAAVAAQLRSPMWLVTRGA
Mvan_0269|M.vanbaalenii_PYR-1 LDSDPDPGTAPSMRSLLRMQHRILGGTRRLFRAAAAAELRTPIWVVTRRA
Rv1527c|M.tuberculosis_H37Rv --------------------------------------------------
Mb1554c|M.bovis_AF2122/97 --------------------------------------------------
MMAR_2340|M.marinum_M --------------------------------------------------
MAV_2370|M.avium_104 --------------------------------------------------
MLBr_00139|M.leprae_Br4923 --------------------------------------------------
MUL_2010|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_4727|M.smegmatis_MC2_155 --------------------------------------------------
MAB_3148c|M.abscessus_ATCC_199 --------------------------------------------------
TH_4621|M.thermoresistible__bu --------------------------------------------------
Mflv_0405|M.gilvum_PYR-GCK QHVTDTDVVAPDQTCLWGFGRAASLEHPQIWGGLADLGGGTSDEWSRLLN
Mvan_0269|M.vanbaalenii_PYR-1 QHVTATDTVAPDQSCLWGFGRAAALELPQLWGGLADLADGTADEWSRLLN
Rv1527c|M.tuberculosis_H37Rv --------------------------------------------------
Mb1554c|M.bovis_AF2122/97 --------------------------------------------------
MMAR_2340|M.marinum_M --------------------------------------------------
MAV_2370|M.avium_104 --------------------------------------------------
MLBr_00139|M.leprae_Br4923 --------------------------------------------------
MUL_2010|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_4727|M.smegmatis_MC2_155 --------------------------------------------------
MAB_3148c|M.abscessus_ATCC_199 --------------------------------------------------
TH_4621|M.thermoresistible__bu --------------------------------------------------
Mflv_0405|M.gilvum_PYR-GCK RIAATHDPAVMEDQVAVRGSTSYVPRLVHRDTLPSGKPLHLRADATYLVT
Mvan_0269|M.vanbaalenii_PYR-1 RITAPHGPAVREDQIALRDHAVYVPRLVRRAGRPAGKPLQLRDDATYLVT
Rv1527c|M.tuberculosis_H37Rv --------------------------------------------------
Mb1554c|M.bovis_AF2122/97 --------------------------------------------------
MMAR_2340|M.marinum_M --------------------------------------------------
MAV_2370|M.avium_104 --------------------------------------------------
MLBr_00139|M.leprae_Br4923 --------------------------------------------------
MUL_2010|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_4727|M.smegmatis_MC2_155 --------------------------------------------------
MAB_3148c|M.abscessus_ATCC_199 --------------------------------------------------
TH_4621|M.thermoresistible__bu --------------------------------------------------
Mflv_0405|M.gilvum_PYR-GCK GGLGSLGLEIAGYLAANGAGHLVLTSRRTPDEAAASRIEALRERHGCEVR
Mvan_0269|M.vanbaalenii_PYR-1 GGLGSIGLEIAGYLAAHGARHLVLTSRRAPGDATQQRIDALGAQHSCQIR
Rv1527c|M.tuberculosis_H37Rv --------------------------------------------------
Mb1554c|M.bovis_AF2122/97 --------------------------------------------------
MMAR_2340|M.marinum_M --------------------------------------------------
MAV_2370|M.avium_104 --------------------------------------------------
MLBr_00139|M.leprae_Br4923 --------------------------------------------------
MUL_2010|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_4727|M.smegmatis_MC2_155 --------------------------------------------------
MAB_3148c|M.abscessus_ATCC_199 --------------------------------------------------
TH_4621|M.thermoresistible__bu --------------------------------------------------
Mflv_0405|M.gilvum_PYR-GCK VVTADVADAHAVARLLATVQAEMPPLAGIVHAAGEIGTTPLADLDDAEVD
Mvan_0269|M.vanbaalenii_PYR-1 VVAADVADAHDVARLLAAVAAELPPLAGIVHAAGEIGTTPLVSLEDSEVD
Rv1527c|M.tuberculosis_H37Rv --------------------------------------------------
Mb1554c|M.bovis_AF2122/97 --------------------------------------------------
MMAR_2340|M.marinum_M --------------------------------------------------
MAV_2370|M.avium_104 --------------------------------------------------
MLBr_00139|M.leprae_Br4923 --------------------------------------------------
MUL_2010|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_4727|M.smegmatis_MC2_155 --------------------------------------------------
MAB_3148c|M.abscessus_ATCC_199 --------------------------------------------------
TH_4621|M.thermoresistible__bu --------------------------------------------------
Mflv_0405|M.gilvum_PYR-GCK RVFAGKVWGAWHLSEATSDLQLDFFISTSSIASVWGGFGQAAYGAANAFL
Mvan_0269|M.vanbaalenii_PYR-1 RVFAGKVWGAWHLSEAAADLQLDFFLGTSSIASVWGGYGQTAYGAANAFL
Rv1527c|M.tuberculosis_H37Rv --------------------------------------------------
Mb1554c|M.bovis_AF2122/97 --------------------------------------------------
MMAR_2340|M.marinum_M --------------------------------------------------
MAV_2370|M.avium_104 --------------------------------------------------
MLBr_00139|M.leprae_Br4923 --------------------------------------------------
MUL_2010|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_4727|M.smegmatis_MC2_155 --------------------------------------------------
MAB_3148c|M.abscessus_ATCC_199 --------------------------------------------------
TH_4621|M.thermoresistible__bu --------------------------------------------------
Mflv_0405|M.gilvum_PYR-GCK DGLAWRLREQGVAGVSVNFGPWSAGMADAQSRARLEQRGIKTLSPADALA
Mvan_0269|M.vanbaalenii_PYR-1 DGLAWRLREQGISGVSINFGPWSAGMADAESRARLDQRGVRTLSPADALA
Rv1527c|M.tuberculosis_H37Rv --------------------------------------------------
Mb1554c|M.bovis_AF2122/97 --------------------------------------------------
MMAR_2340|M.marinum_M --------------------------------------------------
MAV_2370|M.avium_104 --------------------------------------------------
MLBr_00139|M.leprae_Br4923 --------------------------------------------------
MUL_2010|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_4727|M.smegmatis_MC2_155 --------------------------------------------------
MAB_3148c|M.abscessus_ATCC_199 --------------------------------------------------
TH_4621|M.thermoresistible__bu --------------------------------------------------
Mflv_0405|M.gilvum_PYR-GCK GLSDAVISAAP----HPVVARVDWSRFLPLYQQAGRRGFLAELERELPAA
Mvan_0269|M.vanbaalenii_PYR-1 GLADVVTAAEAPGPAQGIVARIDWERFLPLYQQAGRRAFLAELEREVPDT
Rv1527c|M.tuberculosis_H37Rv --------------------------------------------------
Mb1554c|M.bovis_AF2122/97 --------------------------------------------------
MMAR_2340|M.marinum_M --------------------------------------------------
MAV_2370|M.avium_104 --------------------------------------------------
MLBr_00139|M.leprae_Br4923 --------------------------------------------------
MUL_2010|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_4727|M.smegmatis_MC2_155 --------------------------------------------------
MAB_3148c|M.abscessus_ATCC_199 --------------------------------------------------
TH_4621|M.thermoresistible__bu --------------------------------------------------
Mflv_0405|M.gilvum_PYR-GCK PAQQGPAVTASGRTPLVERLTTAPLQQRKRLLTDYLRDAVAEVTRVDAAE
Mvan_0269|M.vanbaalenii_PYR-1 ----APAATPSGRTELVERLTNAPVQQRKKLLTDYLRTAVAEITRVDATE
Rv1527c|M.tuberculosis_H37Rv --------------------------------------------------
Mb1554c|M.bovis_AF2122/97 --------------------------------------------------
MMAR_2340|M.marinum_M --------------------------------------------------
MAV_2370|M.avium_104 --------------------------------------------------
MLBr_00139|M.leprae_Br4923 --------------------------------------------------
MUL_2010|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_4727|M.smegmatis_MC2_155 --------------------------------------------------
MAB_3148c|M.abscessus_ATCC_199 --------------------------------------------------
TH_4621|M.thermoresistible__bu --------------------------------------------------
Mflv_0405|M.gilvum_PYR-GCK IREDAGFFDLGMDSLMAVELRRRIETGVGKEIPVTLVMDHPRLSDAADYL
Mvan_0269|M.vanbaalenii_PYR-1 IREDAGFFDLGMDSLMAVELRRRIEQGVGREIPATLAMDHPRLSDVADYL
Rv1527c|M.tuberculosis_H37Rv --------------MGKERTKTVDRTRVTPVAVIGMGCRLPGGIDSPDRL
Mb1554c|M.bovis_AF2122/97 --------------MGKERTKTVDRTRVTPVAVIGMGCRLPGGIDSPDRL
MMAR_2340|M.marinum_M ---------------------------MTPVAVIGMACRLPGGIGSPEEL
MAV_2370|M.avium_104 ---------------------------MVPVAVIGMACRLPGAVDSPERL
MLBr_00139|M.leprae_Br4923 -----------------------METSVTPIAVIGMGCRLPGGINSPDKL
MUL_2010|M.ulcerans_Agy99 -----------------------MQKSATPVAIIGMGCRLPGGVDSPEKL
MSMEG_4727|M.smegmatis_MC2_155 ----------------------MTQNCVAPVAIIGMACRLPGAINSPQQL
MAB_3148c|M.abscessus_ATCC_199 -----------------------------------MGCRLPGGIESPEQF
TH_4621|M.thermoresistible__bu -------------------VNIVGDTPVNAVAVIGMACRLPGGIDSPQRL
Mflv_0405|M.gilvum_PYR-GCK LGDVLGLTEAATAPKAATVVSTAA---DEPIAIVAVSCRFPGAPN-PEAF
Mvan_0269|M.vanbaalenii_PYR-1 LGEVLGLAEQAPAKAGSQPASAAANRTDEPIAIVAVSCRFPGAPD-PEAF
:.**:**. *: :
Rv1527c|M.tuberculosis_H37Rv WEALLRGDDLVTEIPADRWDIDEYYDPEPGVPGRTDCKWGAYLDNVGDFD
Mb1554c|M.bovis_AF2122/97 WEALLRGDDLVTEIPADRWDIDEYYDPEPGVPGRTDCKWGAYLDNVGDFD
MMAR_2340|M.marinum_M WEALLRGDDLVTEIPADRWDADEYYDPEPGVPGRTVCKWGAFLDNVGDFD
MAV_2370|M.avium_104 WEALLRGDDFVTEIPPDRWDADEYYDPEPGVPGRSVSRWGAFIDDVAGFD
MLBr_00139|M.leprae_Br4923 WESLLRGDNLVTEVPPDRWDVDDFYDPEPGVPGRSVSRWGGFLDDVAGFD
MUL_2010|M.ulcerans_Agy99 WESLLRGDDLVSEIPPDRWDVDDYYDPEPGVPGRTVSRWGGFIDDVAGFD
MSMEG_4727|M.smegmatis_MC2_155 WEALLRGDDFVTEIPTGRWDAEEYYDPEPGVPGRSVSKWGAFLDDPAAFD
MAB_3148c|M.abscessus_ATCC_199 WQALLRGEDFITEVPPARWDLTEYYDPESGVPGKSPSKWGAFLEDVGGFD
TH_4621|M.thermoresistible__bu WEALLRGDDMVTEIPVDRWDADDYFDPEPGVPGRTVSRWGAFLDDVAGFD
Mflv_0405|M.gilvum_PYR-GCK WDLLSGGVDAIREVPEDRFDIDEFYDPDPDAAGKTYTRYGGFLDHIDEFD
Mvan_0269|M.vanbaalenii_PYR-1 WEVLAGGVDAIREVPEDRFDIDEFYDPDPDAAGKTYTRFGGFLDGIDGFD
*: * * : : *:* *:* :::**:....*:: ::*.::: **
Rv1527c|M.tuberculosis_H37Rv PEFFGIGEKEAIAIDPQHRLLLETSWEAMEHGGLTPNQMAS-RTGVFVGL
Mb1554c|M.bovis_AF2122/97 PEFFGIGEKEAIAIDPQHRLLLETSWEAMEHGGLTPNQMAS-RTGVFVGL
MMAR_2340|M.marinum_M PEFFGITEKEAIAIDPQHRMLLETAWEAMEHGGLTPEQMAESLTGVFVGL
MAV_2370|M.avium_104 PEFFGINEREATAMDPQHRLLLETSWEAMEHAGLTEERVADSRTGVFIGL
MLBr_00139|M.leprae_Br4923 AEFFGISEREATSIDPQQRLLLETSWEAIEQGGLDPASLAGSSTAVFTGL
MUL_2010|M.ulcerans_Agy99 AEFFGVSEREATSIDPQHRQLLETAWEAIEHAGLDPASLSGSSTGVFVGL
MSMEG_4727|M.smegmatis_MC2_155 PEFFGITEREAAAIDPQHRLLLETAWEAVEHSGLNPAGLAGSATGVFMGL
MAB_3148c|M.abscessus_ATCC_199 ADFFSINEREAVSIDPQHRVLLETSWQAVEHAGIDPRALAGSQTGVFVGV
TH_4621|M.thermoresistible__bu PEFFGISEREAISIDPQQRLLLETSWEAMEHAGLTPADVEGSSTGVFVGL
Mflv_0405|M.gilvum_PYR-GCK PEFFGLSPREAVWIEPQQRLMLETVWEGLERAGYAPSALRGSRTGVFVGV
Mvan_0269|M.vanbaalenii_PYR-1 PEFFGISPREAVWIEPQQRLMLETVWEGLERAGLAPADLRGSRTGIFVGV
.:**.: :** ::**:* :*** *:.:*:.* : *.:* *:
Rv1527c|M.tuberculosis_H37Rv VHTDYILVH-ADNQTFEGPYGNTGTNACFASGRVAYAMGLQGPAITVDTA
Mb1554c|M.bovis_AF2122/97 VHTDYILVH-ADNQTFEGPYGNTGTNACFASGRVAYAMGLQGPAITVDTA
MMAR_2340|M.marinum_M NHGDYQFVH-VDANTFDGPYGNTGTNSCFASGRISYAMRLHGPAVTVDTA
MAV_2370|M.avium_104 THGDYQLLA-ADTRSVEGAYGFSGSNFSLASGRIAYALGVHGPALTVDTA
MLBr_00139|M.leprae_Br4923 THEDYLVLT-TAAGGLASPYVVTGLNNSVASGRISHTLGLHGPAMTFDTA
MUL_2010|M.ulcerans_Agy99 SHEDYLVRS-VLAGDLAGPYASTGLINSVASGRIAHTLGLHGPAMTVDTA
MSMEG_4727|M.smegmatis_MC2_155 THNDYAHLA-ADAKALEGPYGFTGTSFSLASGRIAYALGVHGPAITVDTA
MAB_3148c|M.abscessus_ATCC_199 THNDYQLVA-ADAADLGGPYGFAGTNFCMASGRISYALGVHGPSLTVDAG
TH_4621|M.thermoresistible__bu SHDDYALLT-SDAGALEEAYGFTGSAFSMASGRIAYRLGVHGPAVTVDTA
Mflv_0405|M.gilvum_PYR-GCK AANEYAHLLSAESIDKIEPHFITGNALNAISGRVAFALGLEGPAVAVDTA
Mvan_0269|M.vanbaalenii_PYR-1 AANEYAHLLSSESIEKIEPHFITGNALNAISGRVAFALGLEGPAVAVDTA
:* .: :* ***::. : :.**:::.*:.
Rv1527c|M.tuberculosis_H37Rv CSSGLTAIHLACRSLHDGESDIALAGGVYVMLEPRRFASGSALGMLSATG
Mb1554c|M.bovis_AF2122/97 CSSGLTAIHLACRSLHDGESDIALAGGVYVMLEPRRFASGSALGMLSATG
MMAR_2340|M.marinum_M CSSSLYATHLACNSLSEGESDLAFAAGVYVMLEPRRFASGSAQNMLSPTG
MAV_2370|M.avium_104 CSSGLTAIHLACRSLHEGESDLALAGGATLALDPRKFSAGSAEGMLSPTG
MLBr_00139|M.leprae_Br4923 CSSGLMAVHLACRSLHDGESDLALAGGCAVLLEPHASVAASAQGMLSSTG
MUL_2010|M.ulcerans_Agy99 CSSGLLTVHLACRSLHEGESDLALAGGCALLLEPNGSVSLSSQGMLSPTG
MSMEG_4727|M.smegmatis_MC2_155 CSSSLSAIHMACRSLHDGESDVALAGGVSVLLEPRKAAGGSAAGMLSPTG
MAB_3148c|M.abscessus_ATCC_199 CAAGLATVHMGCQSLAAGESDLVLAGGVNLVLEPRRYVGASQQRMLSPTG
TH_4621|M.thermoresistible__bu CSSSLLAVHMACRSLQVGESDLALAGGAMVMLEPRKYTSASGLGMLSPTG
Mflv_0405|M.gilvum_PYR-GCK CSSSLVAVHQATQALRSGDCDMALAGGVNVLLSPVTVVAASRARMLSPVG
Mvan_0269|M.vanbaalenii_PYR-1 CSSALVAVHQACQALHSGDCDLALAGGVNVLLSPVTSVAASRARMLSPVG
*::.* : * . .:* *:.*:.:*.* : *.* . * ***..*
Rv1527c|M.tuberculosis_H37Rv RCHAFDVSADGFVSGEGCVMLALKRLPDALADGDRILAVIRGTAANQDGH
Mb1554c|M.bovis_AF2122/97 RCHAFDVSADGFVSGEGCVMLALKRLPDALADGDRILAVIRGTAANQDGH
MMAR_2340|M.marinum_M HCHAFDVDADGFVSGEGSVVLLLKRLADAQRDGDRILAVMRGTAANQDGH
MAV_2370|M.avium_104 RCHAFDVAADGFVGGEGSVMLLLKRLNDALRDGDRILAVVRGTAANQDGH
MLBr_00139|M.leprae_Br4923 RCKSFAADADGFVRSEGCAMVLLKRLPDALRDGNRIFAMILGTATNQDGG
MUL_2010|M.ulcerans_Agy99 RCHAFDVDADGFVRSEGCAVVVLKRLSDALADGDRILAVVRGTAANQDGR
MSMEG_4727|M.smegmatis_MC2_155 HCHAFDTAADGFVSAEGCVVLTLKRLDDAVADGDRILAVIRGTATNQDGR
MAB_3148c|M.abscessus_ATCC_199 RCHTFTGEADGFVMSEGCVMVLLKRLDDAVRDGDRILAVVRGTASNQDGR
TH_4621|M.thermoresistible__bu RCHAFDVAADGFVRSEGSVMLLLKRLPDALRDNDRILAVVRGTAANQDGR
Mflv_0405|M.gilvum_PYR-GCK RCKTFDASADGYVRSEGCGILVLKRLSDAVRDGDRVCAVIAGSAVNQDGA
Mvan_0269|M.vanbaalenii_PYR-1 RCKTFDASADGYVRSEGCGILVLKRLGDAVRDGDRVCAVIPSSAVNQDGA
:*::* ***:* .**. :: **** ** *.:*: *:: .:* ****
Rv1527c|M.tuberculosis_H37Rv TVNIATPSRSAQVAAYREALDVAGVDPATVGMVEAHGPGTPVGDPIEYAS
Mb1554c|M.bovis_AF2122/97 TVNIATPSRSAQVAAYREALDVAGVDPATVGMVEAHGPGTPVGDPIEYAS
MMAR_2340|M.marinum_M TVNIATPSVEAQSAVYRAALATAGVDGASVGLVEAHGTGTPVGDPIEFES
MAV_2370|M.avium_104 TVNIATPSKTAQTAVYRAALAAAGVDAGTVGMVEAHGPGTPVGDPIEYAS
MLBr_00139|M.leprae_Br4923 TETLMMPSEDAQVAVYQAALAVAGVEPETIGVVEAHGTGTPIGDPIEYRS
MUL_2010|M.ulcerans_Agy99 SETLLMPSETAQVAVYREALAAAGVDAASVGAVEVHGTGTPVGDPIEYRS
MSMEG_4727|M.smegmatis_MC2_155 TVNIATPSADAQAKVYRMALKAAGVEPGTVGLVEAHGTGTPVGDPLEFSS
MAB_3148c|M.abscessus_ATCC_199 TVNQSTPSSEAQAAACRTALAVAGVEADTVGLIEAHGTGTPVGDPIEYTG
TH_4621|M.thermoresistible__bu TENISTPSIQAQADVYRSALAVAGVDPATVGMVEAHGTGTPVGDPIEYNS
Mflv_0405|M.gilvum_PYR-GCK SSGLTVPNGGAQQRLIGTVLARAGITGGEVDYLEAHGTGTPLGDPIEVQA
Mvan_0269|M.vanbaalenii_PYR-1 SSGLTVPNGGAQQRLIGMALARAGLSGGDVDYLEAHGTGTPLGDPIEVQA
: *. ** .* **: :. :*.**.***:***:* .
Rv1527c|M.tuberculosis_H37Rv LAEVYGND----GPCALASVKTNFGHTQSAAGALGLMKAVLALQHGVVPQ
Mb1554c|M.bovis_AF2122/97 LAEVYGND----GPCALASVKTNFGHTQSAAGALGLMKAVLALQHGVVPQ
MMAR_2340|M.marinum_M LARVYGID----RPCALTSAKPNFGHMQAGAGVLGLMKAILALQHGVIPP
MAV_2370|M.avium_104 LAEVYGID----GPCALASVKTNFGHAQAASGALGMMKAILALQHGVVPR
MLBr_00139|M.leprae_Br4923 LARVYGAG----TPCALGSAKSNMGHSTASAGTVGLIKAILSLRNGLVPP
MUL_2010|M.ulcerans_Agy99 LAQVYGSGG---SRCMLGSVKTNIGHSESAAGTVGLIKATLSLGHGVVPP
MSMEG_4727|M.smegmatis_MC2_155 LAEVYGTD----GPCALGSIKTNFGHTQSAAGALGVMKAVLALQHNVIPQ
MAB_3148c|M.abscessus_ATCC_199 LAQVYGVD----GPCAVGSVKTNFGHTMSAAGALGLMKIVLAVEHGVVPP
TH_4621|M.thermoresistible__bu LTQVYGKT----GPCALTSVKTNFGHAESAAGALGMMKAILALQHGVVPQ
Mflv_0405|M.gilvum_PYR-GCK AAAAYAGARDADRPLLMGSVKTNIGHTESASGAAGLIKVVLSLQHETLPQ
Mvan_0269|M.vanbaalenii_PYR-1 AAAAYGASRDADRPLLMGSVKTNIGHLESASGAAGLIKVVLSLQHNLLPQ
: .*. : * *.*:** :.:*. *::* *:: : :*
Rv1527c|M.tuberculosis_H37Rv NLHFTALPDKLAAIETNLFVPQEITPWPGADQETPRRAAVSSYGMTGTNV
Mb1554c|M.bovis_AF2122/97 NLHFTALPDKLAAIETNLFVPQEITPWPGADQETPRRAAVSSYGMTGTNV
MMAR_2340|M.marinum_M NIHFSRLPDEMAQIKSGLFVPQEITQWP-TNGEQTRTAAVSSYGISGTNV
MAV_2370|M.avium_104 NLHFTQLPDDLARIDTKLFVPQQTTPWV-SNGGHPRRAAVSSYGLSGTNV
MLBr_00139|M.leprae_Br4923 LLHFDRLSDDLTEIETGLFVPQEVTPWPVGGYNTPKRVAVSSFGMSGTNV
MUL_2010|M.ulcerans_Agy99 MVHHTRLPDELAEIETGLYVPHEITPWPED--QGPRRIAVSSFGMSGTNV
MSMEG_4727|M.smegmatis_MC2_155 NLHFTRLPDQMAEIETGLFVPETITPWP-VREGQPRRAAVSAYGLSGTNV
MAB_3148c|M.abscessus_ATCC_199 NLHFTGIPDKLAPVKTNLFVPQTVIPWP-GKAQGPRRAGVSAYGMSGSNV
TH_4621|M.thermoresistible__bu NLHFTRLPDEMAAIETNLFVPQATTLWP-VREGCPRRAAVSSYGMSGTNV
Mflv_0405|M.gilvum_PYR-GCK SLHFDTPSPHIPWDSLPVRVVDTAMPWQ--PNGRPRRAGVSSFGFTGTNA
Mvan_0269|M.vanbaalenii_PYR-1 SLHFENPSPHIPWDSLPVRVVDKAIPWQ--ADGRPRRAGVSSFGFTGTNA
:*. . .:. . : * . * .: .**::*::*:*.
Rv1527c|M.tuberculosis_H37Rv HAIVEQAPVPAPE--------SGAPGDTPATPGIDGALLFALSASSQDAL
Mb1554c|M.bovis_AF2122/97 HAIVEQAPVPAPE--------SGAPGDTPATPGIDGALLFALSASSQDAL
MMAR_2340|M.marinum_M HAILEQAPETATH--------DAEP----VSPAIEGALIFPLSATSADGL
MAV_2370|M.avium_104 HAILEQAPEPAPE--------TVAP----EGISAESPLLFPLSSTSADEL
MLBr_00139|M.leprae_Br4923 HVIVEEAPSEACAP-------DVPETSPGTGDATVGRQLFMLSSTSIAAL
MUL_2010|M.ulcerans_Agy99 HAILEEPPTPAPAR-------DQASAEPG----MASPLLFALSSTSADGL
MSMEG_4727|M.smegmatis_MC2_155 HAVLEQAPESPAET-------AAEAIS----PKAGNALVFPVSASSADAL
MAB_3148c|M.abscessus_ATCC_199 HAVVEQAPPVESST-------PPAVES-----PLGSQLIFPVSSTSAEEL
TH_4621|M.thermoresistible__bu HAVLEQAPEPVQRP-------EESADT-----DAAGPLVFALSSTSAEEL
Mflv_0405|M.gilvum_PYR-GCK HVLIEEAPTDLAGPTEPTAPAEPVDEDAAADPAPAPVEVLPLSARSPEAL
Mvan_0269|M.vanbaalenii_PYR-1 HVLIEEAPLPQA--------ADPVEE---PDTRALPVGVLALSARSPEAL
*.::*:.* :: :*: * *
Rv1527c|M.tuberculosis_H37Rv RQTAARLADWV------DAQGPELAPADLAYTLARRRGHRPVRTAVLAAT
Mb1554c|M.bovis_AF2122/97 RQTAARLADWV------DAQGPELAPADLAYTLARRRGHRPVRTAVLAAT
MMAR_2340|M.marinum_M RQTAKRLADWV------DAQGPELATSDLAYTLARRRGHRPVRTAVLADN
MAV_2370|M.avium_104 RRTAGRLADWV------HAHG-DLALPDLAYTLARRRVHRPVRTAVLAGD
MLBr_00139|M.leprae_Br4923 RETARQLATWV------EEHQDSVVLSDLAYTLARGRAHRPVRTAVVAAD
MUL_2010|M.ulcerans_Agy99 RQTARELAEWVGSR---ADSADSTEAVDLAYTLARRRAHRPVRTAVVAAS
MSMEG_4727|M.smegmatis_MC2_155 RSTAQHLADWLLRSGDGNGRGPAIDLGDLAYTLARRRGFRAARSAVLAGD
MAB_3148c|M.abscessus_ATCC_199 RRTAARLADWV-------AERPEVAPGDVGYTLARRRAHRSVRTAVVADG
TH_4621|M.thermoresistible__bu RRTAGRLAEWV------EAHTDEVVPADLAYTLARRRAHRPVRTTVIADG
Mflv_0405|M.gilvum_PYR-GCK VALAQRYETWLT-------AHPEADLADVCRTAGTGRSHFEHRAALVVDS
Mvan_0269|M.vanbaalenii_PYR-1 TALAQRYEAWLS-------AHPDADLADVCRTAGTGRSHFEHRAALVVDS
* . *: *: * . * . *::::.
Rv1527c|M.tuberculosis_H37Rv TAELTEALREVATGEPPYPPAVGQDDRGP--VWVFSGQGSQWAGMGADLL
Mb1554c|M.bovis_AF2122/97 TAELTEALREVATGETPYPPAVGQDDRGP--VWVFSGQGSQWAGMGADLL
MMAR_2340|M.marinum_M VSELSAGLHEIADDETPYQAAVGRDDRGP--VWVFSGQGSQWKAMGADLL
MAV_2370|M.avium_104 RAQLIEALREVADGDTPYPAAVGRGDRGP--VWVFSGQGSQWAAMGADLL
MLBr_00139|M.leprae_Br4923 LPELVEGLCEIADGDALYDAVVGHGDRGP--VWVFSGQGSQWASMGVQLL
MUL_2010|M.ulcerans_Agy99 LPELVEGLQEVAEGDLVYEAAVGRGDRGP--VWVFSGQGSQWAAMGADLL
MSMEG_4727|M.smegmatis_MC2_155 RGTLVEGLRQIADGEAMPQQAVTNDDRGP--VWVFSGQGSQWASMGAELL
MAB_3148c|M.abscessus_ATCC_199 ADELIDALRGVAEGDAPYPAAVAQDDRGP--VWLFSGQGSQWAGMGAELL
TH_4621|M.thermoresistible__bu VEALTAGLREVADGDAPYQPAVGMDDKAP--VWVFSGQGSQWAGMGAELL
Mflv_0405|M.gilvum_PYR-GCK VESARIALTDLAQNRLRPGVVRGEHLNHPTTAWMFTGQGSQYPGMARELF
Mvan_0269|M.vanbaalenii_PYR-1 VAAAREGLAELAQNRLRPGVVRGEHTHHPTTAWLFTGQGSQFPGMARELF
.* :* . . . * .*:*:*****: .*. :*:
Rv1527c|M.tuberculosis_H37Rv ATEPVFAATIAAIEPLIAAESGFSVTEAMTAPEVVTG---------IDRV
Mb1554c|M.bovis_AF2122/97 ATEPVFAATIAAIEPLIAAESGFSVTEAMTAPEVVTG---------IDRV
MMAR_2340|M.marinum_M ANEPVFAATVAELEPLIAAESGFSVTEAMTAIETVTG---------IDRV
MAV_2370|M.avium_104 ATEPVFAATVAQAEPLIARESGFSVAEAMSAPQTVTG---------QDRV
MLBr_00139|M.leprae_Br4923 ANEPVFAATITKLEPVIAAESSFSVTEAITAPETVTG---------IDKV
MUL_2010|M.ulcerans_Agy99 ANEPVFAATVAAVEPIIAHESGFSVTEAMTAPEKVTG---------IDKV
MSMEG_4727|M.smegmatis_MC2_155 DREPAFAAAIAELEPLIAAESDFSVTEALTASETVTG---------IDRV
MAB_3148c|M.abscessus_ATCC_199 GKEPVFAETIARLEPLIHAESGFSVTDAISAPETVTG---------IDRV
TH_4621|M.thermoresistible__bu ATEQVFAAKIAEIEPLVARESGFSVTEAMTASETVTG---------IDRV
Mflv_0405|M.gilvum_PYR-GCK DTEPVFADTVTRCADAVADLLPRPLLDVMFAGGREAGVPPTETLRHTSFA
Mvan_0269|M.vanbaalenii_PYR-1 ETEPVFADAVTRCADAVKDILPRPLLEVLFAADRESG----EALRHTSFA
* .** :: : .: :.: * :* . .
Rv1527c|M.tuberculosis_H37Rv QPTLFAMQVALAATMKS-YGVAPGAVIGHSLGESAAAVVAGALCLEDGVR
Mb1554c|M.bovis_AF2122/97 QPTLFAMQVALAATMKS-YGVAPGAVIGHSLGESAAAVVAGALCLEDGVR
MMAR_2340|M.marinum_M QPTIFTMQVALAATMKS-YGVRPGAIIGHSLGESAAAVAAGALSLEDGAK
MAV_2370|M.avium_104 QPTLFTMQVALAATMKA-HGVRPGAVIGHSLGEAAAAVVAGALSLEDGAR
MLBr_00139|M.leprae_Br4923 QPSVFAVQVALATTMEQTYGVRPGAVIGHSMGESAAAVVAGALSLEDAAR
MUL_2010|M.ulcerans_Agy99 QPTLFAMQVALAATMEKTYGVRPGAVIGHSLGEAAAAVVAGSLSLEDGAR
MSMEG_4727|M.smegmatis_MC2_155 QPTIFAVQVALAAAMRS-HGVVPGAVIGHSMGEVAASVVSGALSLEDGVK
MAB_3148c|M.abscessus_ATCC_199 QPTLFAMQVSLAATLAS-YGVRPGAVIGHSMGEVAAAVVSEALSLEDGVK
TH_4621|M.thermoresistible__bu QPTLFAIQVALAATMQS-YGVRPGAVIGHSLGEVAAAVVAGALSLEDGVK
Mflv_0405|M.gilvum_PYR-GCK QPALFAVEMGLARLWQS-WGIVPDVVLGHSVGQYAAACVAGVFSLEDGAR
Mvan_0269|M.vanbaalenii_PYR-1 QPAIFAVEMGLARLWQS-WGIEPDVVLGHSVGQYAAACVAGVFSLEDGAR
**::*::::.** *: *..::***:*: **: .: :.***..:
Rv1527c|M.tuberculosis_H37Rv VICRRSALMTRIAGAGAMASVELPAQQVLSELMARGVNDAVVAVVASPQS
Mb1554c|M.bovis_AF2122/97 VICRRSALMTRIAGAGAMASVELPAQQVLSELMARGVNDAVVAVVASPQS
MMAR_2340|M.marinum_M VICRRSRLMTRISGSGAMASVELPAQQVLSELMARGINDVVVAVVASPQS
MAV_2370|M.avium_104 VICRRSRLMSRVAGTGATASVELPAQQVLSELTARGISDVVVAVVASPQS
MLBr_00139|M.leprae_Br4923 VICRRSKLMNRVAGSGAMGSVELPAKQVNSELMARGIDDVVISVVASPQS
MUL_2010|M.ulcerans_Agy99 VISRRSKLMLRISGAGAMASVELPAKQVNSELMARGIDDVAVAVVASPQS
MSMEG_4727|M.smegmatis_MC2_155 VICRRTRLMTRIAGSGAMAMVELPAQQVLSELASRGVDDVVLSVVASPQS
MAB_3148c|M.abscessus_ATCC_199 VICRRSQLMLRISGAGAMASVDLPAQQVVSELADRDIHDVVLAVVASPQS
TH_4621|M.thermoresistible__bu VICRRSRLCLRLAGAGAMAAIELPAQAVREFLAARGVDDVVLSVIASPES
Mflv_0405|M.gilvum_PYR-GCK LMAERGRLFGSLPEGGRMVAVFADAKRVEQVAAD--FPRVSVGAYNGP-N
Mvan_0269|M.vanbaalenii_PYR-1 LMAERGRMFGSLPEGGRMVAVFTDAKLVEEIAGD--FPRVSVGAYNGP-N
::..* : :. * : *: * . . . :.. .* .
Rv1527c|M.tuberculosis_H37Rv TVIGGATQTVRDLVAAWEQRDVLAREVAVDVASHSPQVDPILDELAEALA
Mb1554c|M.bovis_AF2122/97 TVIGGATQTVRDLVAAWEQRDVLAREVAVDVASHSPQVDPILDELAEALA
MMAR_2340|M.marinum_M TVIGGATDTVRELVAAWEQREVMAREVAVDVASHSPQVDPILDDLYDVLA
MAV_2370|M.avium_104 TVIAGAAPTVRDLVTAWQERGVMAREVPTDVAFHSPQVDPIMDDLTDALA
MLBr_00139|M.leprae_Br4923 TVIGGATETVRDLIAQWEQRDVMAREVAVDVASHSSQVDPILDDLAAALA
MUL_2010|M.ulcerans_Agy99 TVVGGATDTVRDLVARWEQREVMAREVAVDVASHSPQVDPILEDLATALA
MSMEG_4727|M.smegmatis_MC2_155 TVVGGATASVRELIEMWESRGVMAREIAVDVASHSPQVDPILDDLIEALA
MAB_3148c|M.abscessus_ATCC_199 TVVGGATETVRQLIAEWSDRGLMAREVAVDVASHSPQVDPILDDLADALE
TH_4621|M.thermoresistible__bu TVIGGATDTVRELVAAWEAQGVMAREVAVDVASHSPQVDPILDELEEILA
Mflv_0405|M.gilvum_PYR-GCK TVLSGPGEDLEQIVGTFGEDGIRCTWLETSHAFHSELLDPVLDEFESYAA
Mvan_0269|M.vanbaalenii_PYR-1 TVLSGPGEDLEQIVDRFGDDGVRCTWLQTSHAFHSELLDPVLDEFESYAA
**:.*. :.::: : : . : .. * ** :**:::::
Rv1527c|M.tuberculosis_H37Rv EISPLQPEIPYYS-ATSFDPREEPYCDAYYWVDNLRHTVRFAAAVQAALE
Mb1554c|M.bovis_AF2122/97 EISPLQPEIPYYS-ATSFDPREEPYCDAYYWVDNLRHTVRFAAAVQAALE
MMAR_2340|M.marinum_M DLEPLTPEVPYYS-ATLFDPREEPYCDGSYWVDNLRHTVRFGAAVQAALE
MAV_2370|M.avium_104 EISPRPPEVPYYS-ATLFDPREQPVCDARYWANNMRRMVRFATAVQAALE
MLBr_00139|M.leprae_Br4923 DIAPMTPKVPYYS-ATLFDPRELPVCNGAYWVDNLRNTVQFAAAVQAAME
MUL_2010|M.ulcerans_Agy99 DIVPSDPKVPYYS-ATLFDPRERPTCDAAYWVDNLRNTVQFAAAVQAALE
MSMEG_4727|M.smegmatis_MC2_155 DLDPAEPEIPYYS-ATLYDPRDYADYDAYYWADNLRHTVRFSAAVQAALE
MAB_3148c|M.abscessus_ATCC_199 DLTPRTPVVPLYS-SVSFDPRERPIMDADYWVDNLRHTVRFAAAVQAALD
TH_4621|M.thermoresistible__bu DLQPMTPTVPYYS-ATSYDPREKPVCDADYWVDNLRHEVRFAAAVQAALE
Mflv_0405|M.gilvum_PYR-GCK QLQFAAPTLPLVCNRTGAVLTGQTSLDAQYWRRHSRQPVQFAESVRTVAA
Mvan_0269|M.vanbaalenii_PYR-1 QFQFATPTLPLVCNRTGTVLTAQTPLDAQYWRRHSRQPVQFAESVRTVAA
:: * :* . . . :. ** : *. *:*. :*::.
Rv1527c|M.tuberculosis_H37Rv DGYRVFTELTPHPLLTHAVDQTARSLDMSAAALAGMRREQPLPHGLRALA
Mb1554c|M.bovis_AF2122/97 DGYRVFTELTPHPLLTHAVDQTARSLDMSAAALAGMRREQPLPHGLRALA
MMAR_2340|M.marinum_M DGYRVFAELAPHPLLTRAVEKTAEGLDMPVAALAGMRREQPLPHGLRGLL
MAV_2370|M.avium_104 DGYRVFAELAPHPLLVRALEQTARSREIPMAALAGMRRGQALPHGLRGFV
MLBr_00139|M.leprae_Br4923 DGYRVFAELSPHPLLTHAVEQTARNLDMSVAALAGMRREQSMPYGLRGLL
MUL_2010|M.ulcerans_Agy99 DGFRVFAELSPHPLLTHAVDQNARSLDMSAAVLAGMRREQPLPHGLRGLL
MSMEG_4727|M.smegmatis_MC2_155 DGHRVFAELSPHPLLTHPVEQTARSLDMPLAVFAAMRRQQEMPHGLLGFV
MAB_3148c|M.abscessus_ATCC_199 DGYRVFGELAPHPLLVYPAEQTARSLDIPMVALAGMRREQELPHGLRDFV
TH_4621|M.thermoresistible__bu DGFRVFGELSPHPLLTRAVEQTARGLDMPVAALPAMRREQEMPHGVRTMV
Mflv_0405|M.gilvum_PYR-GCK LGCSVLMEIGPQPVLTGAAVQVWPEHLAAPRAIASLRKGVADRRQIADAL
Mvan_0269|M.vanbaalenii_PYR-1 LGCSVLMEIGPQPVLTGSAVQVWPEHLAAPRAIVSLRKGVSDRRQITEAL
* *: *: *:*:*. . : . .: .:*: :
Rv1527c|M.tuberculosis_H37Rv GDLYAAGAAVDFAVLYPTGRLINAPLPTWNHRRLLLDDT--TRRIAHANT
Mb1554c|M.bovis_AF2122/97 GDLYAAGAAVDFAVLYPTGRLINAPLPTWNHRRLLLDDT--TRRIAHANT
MMAR_2340|M.marinum_M ADLHSAGAAVDFSVLYPAGELVDAPLPAWTHQSLLLNRAGQDHQAQGGSS
MAV_2370|M.avium_104 ADLHNAGAAVDFSVLYPTGRLVDAPLPTWTHRRLWLTDGGLESPTHGGCT
MLBr_00139|M.leprae_Br4923 ADLHSAGAALDFAALYPAGRLLDAPLPVWTHPRLFIDTDGQEQRAQGACT
MUL_2010|M.ulcerans_Agy99 TDVHSAGAAVDFSVLYPAGRLVNAPPPAWTHRRFFVDGEGQDSKAQGACS
MSMEG_4727|M.smegmatis_MC2_155 ADLHSAGAAVDFSVLYPTGRLLDAPLPAWTHSTLLLDRE-LESSAPGVPS
MAB_3148c|M.abscessus_ATCC_199 GDLYTAGGAVDFSVLYPTGQLVDVPLPSWTRRSYLLDLSAQAQQGHGTHT
TH_4621|M.thermoresistible__bu GDLFAAGAAVDFAALYPSGRLVDAPLPTWTRRKLVLSRENGEQQTRGGCT
Mflv_0405|M.gilvum_PYR-GCK AAAYIGGHKPDFAALHEQRGVRLELPTYPFQRRRFWPKSAGMAIDGRVGA
Mvan_0269|M.vanbaalenii_PYR-1 AAAYVGGHRPDFGALYRRPGRAVALPTYPFQRRRFWPKTSGITTDG----
. .* **..*: . :
Rv1527c|M.tuberculosis_H37Rv VAVHPLLGSHVRLPEEPERHVWQGEVGTVTQPWLADHQIHGAAALPGAAY
Mb1554c|M.bovis_AF2122/97 VAVHPLLGSHVRLPEEPERHVWQGEVGTVTQPWLADHQIHGAAALPGAAY
MMAR_2340|M.marinum_M VVVHPLLGSHVLLPEEPERHVWQSDVGTEALPWLADHQIHSAPALPGAAY
MAV_2370|M.avium_104 VAVHPLLGPHVHLQEEPERHLWQADVGTAAQPWLADHQIRNVVVLPGAAY
MLBr_00139|M.leprae_Br4923 VTVHPLLGSHVRLLEEPERHIWQGDVGTAALSWLADHQVHNVAALPGAAY
MUL_2010|M.ulcerans_Agy99 VTVHPLLGAHVRLSEQPERHVWQTDVGTDTLSWLSDHQVRNVAALPGAAY
MSMEG_4727|M.smegmatis_MC2_155 VSVHPLLGSHVVLPQEPEEHLWQGDVGTEAHPWLSDHRVHQVAVLPGAAY
MAB_3148c|M.abscessus_ATCC_199 VAVHPLLGAHVRLAEEPERHIWQADVGTVGQPWIADHQVRHVAVYPGAAY
TH_4621|M.thermoresistible__bu ITVHPLLGTHVRLPEEPERHVWQADLGTGAQPWLADHQIHTVAALPGAAY
Mflv_0405|M.gilvum_PYR-GCK SAGSGILGSGKDLASG--DSVYTSRLSVKTQPWLSDHVIYGTVVVPGATY
Mvan_0269|M.vanbaalenii_PYR-1 PAVSGILGSAKDLASG--DTVYTSRWSVRSQPWLADHVIYGTVVVPGATY
:**. * . :: .. .*::** : . . ***:*
Rv1527c|M.tuberculosis_H37Rv CEMALAAARAVLG-EASEVRDIRFEQMLLLDDETPIGVTATVEAP--GVV
Mb1554c|M.bovis_AF2122/97 CEMALAAARAVLG-EASEVRDIRFEQMLLLDDETPIGVTATVEAP--GVV
MMAR_2340|M.marinum_M CEMALVAARTILG-DAAEVRDVRFEQMLLLDDETPLSAVGSVKSP--GIV
MAV_2370|M.avium_104 CEMALAAARSVLG-ATAEVRDIRFEQALLLDEQTTVDASASVSSP--GVL
MLBr_00139|M.leprae_Br4923 CEMALAAAVEVFG-EAAEVRAIAFEQMLLLAAETPIDAIASVDAP--GVI
MUL_2010|M.ulcerans_Agy99 CEMALAAAGEVFG-EAFEVRDLAFEQMLLLDEETPIDAVASLDSP--GAA
MSMEG_4727|M.smegmatis_MC2_155 CEMALAAVTPVLG-DTGEVHDLKFHDMLLLDDATPVWVSAAVTAP--GTA
MAB_3148c|M.abscessus_ATCC_199 CEMALSAAAAVFG-EGSAVQSISFEQLLTLGESTPISATATAKSA--DIL
TH_4621|M.thermoresistible__bu CEMALAAAREVIDSDGVEVRDVRFEQMLLLDEQTEVSAVASAVEP--GTL
Mflv_0405|M.gilvum_PYR-GCK AAMALAAVGTPAH-----AKDVFFYEPIILPEKSSREVQLTVHPSVDGES
Mvan_0269|M.vanbaalenii_PYR-1 AAMALAAVGTPAR-----VKDVFFYEPIILPEKASREVQLTLHPSEDGGQ
. *** *. .: : * : : * : . : . .
Rv1527c|M.tuberculosis_H37Rv PLTVETSHDGRYTRQLAAVLHVVREADDAPDQPPQKNIAELLASHPHKVD
Mb1554c|M.bovis_AF2122/97 PLTVETSHDGRYTRQLAAVLHVVREADDAPDQPPQKNIAELLASHPHKVD
MMAR_2340|M.marinum_M DFVVETFQDGGAVRRGGAVLHAVEDDD----QLPAYDIPALLAEHSRTED
MAV_2370|M.avium_104 HFTVQSHQGGEQARHASAVLGAATDEQ-----PAAHDLSALLTAHPHDDD
MLBr_00139|M.leprae_Br4923 NFVVQANQDGEKMRNATATLHAAEDDC----PPPAYDIAALLEAHPNSVN
MUL_2010|M.ulcerans_Agy99 NFVVQTHVDGETTRHATAALRASDDES----VPPAYDIAALLAAHPVSVN
MSMEG_4727|M.smegmatis_MC2_155 EFGVETHQSGDRTQRATAVLRGDVDAER----PAAHSIDALLAAHPNRVD
MAB_3148c|M.abscessus_ATCC_199 EFVVETHDEGDVVKRATAVLGNGGDVD----MPIAYDLSALRAEHPHRES
TH_4621|M.thermoresistible__bu EFAVETAKDGEHERRATAVLGAADDTE----PPQAHDIDALLAEHPTRIE
Mflv_0405|M.gilvum_PYR-GCK KFQVHSRPYGERGAEWALNAEGVVASGVGDSPAAAGDLEDPVDEAIERLN
Mvan_0269|M.vanbaalenii_PYR-1 KFQVHSREYGERGTEWSLNAEGTVASGVDENPQAE--PSGPVDEAIERLN
: *.: * . .
Rv1527c|M.tuberculosis_H37Rv ---GAEVRQWLDKRGHRLGPAFAG--LVDAYIAEGAGDTVLAEVNLPGPL
Mb1554c|M.bovis_AF2122/97 ---GAEVRQWLDKRGHRLGPAFAG--LVDAYIAEGAGDTVLAEVNLPGPL
MMAR_2340|M.marinum_M ---GEELRARFDEHGVQYGPAFTG--LGNAHIADGAVSSVVAEVALPGAM
MAV_2370|M.avium_104 ---GDEVRRRMDRRGVQYGPAFAG--LGAVHSGD-ETGTVLAEVALPRQI
MLBr_00139|M.leprae_Br4923 ---GTDLRESFAERGVQLGAAFAG--LATAHTAEAESGTVLAEVALPASI
MUL_2010|M.ulcerans_Agy99 ---GAELREAFVERGIQHGPAFSG--LAIARTAETEGGTVLAEVALPASI
MSMEG_4727|M.smegmatis_MC2_155 ---GDELRAGFGTVGIGHGAAFAG--LSEAYVATAAEPTVVAAVALPGPL
MAB_3148c|M.abscessus_ATCC_199 ---GDDLRASFDERGVQYGPAFQG--LAAAYRGDETVRSVLAEVTLPRDV
TH_4621|M.thermoresistible__bu ---GDELRQWFDQRGVQFGPAFTG--LTAARIPEGTVTSVLAEVGLPGQI
Mflv_0405|M.gilvum_PYR-GCK RMRPQELFETFADLELAWGPTWSGSLKSLWLGEGEAIGDILVGAELAEQL
Mvan_0269|M.vanbaalenii_PYR-1 RMRPQDLFETFADMELAWGPTWSGSLKSLWLGEGEAIGDILVGEELAEQL
:: : *.:: * ::. *. :
Rv1527c|M.tuberculosis_H37Rv RSQVKAYGVHPVLLDACFQSVAAHPAVQGMAD-GGLLLPLGVRRLRSYGS
Mb1554c|M.bovis_AF2122/97 RSQVKAYGVHPVLLDACFQSVAAHPAVQGMAD-GGLLLPLGVRRLRSYGS
MMAR_2340|M.marinum_M RSQQRAYAIHPALLDACFQAVGAHPDVQVAGN-GGLMLPLGVRQIRAYAS
MAV_2370|M.avium_104 RSQQAAYGAHPALLDACFQSVEAHPAVRALGD-GALGLVLGIRRLRAYGA
MLBr_00139|M.leprae_Br4923 RFQQSSYQIHPALLDACFQSVGAGVDATKVGSRAGLLLPLGVRSLRVYRP
MUL_2010|M.ulcerans_Agy99 RFQQGAYGVHPALLDACFQSVAAGVKSTGGG---GLLLPLGVRSLRAYGP
MSMEG_4727|M.smegmatis_MC2_155 RSGQRGYTVHPALLDACFQSVIAHPEVQNIAS--GMLLPLGVRRLRAYGS
MAB_3148c|M.abscessus_ATCC_199 RAQQGSYIVHPALLDACFQSVIALPDVQEASK-DALPLPKGVRSLHAYES
TH_4621|M.thermoresistible__bu RSQQAPYGIHPALLDACFQSVAAHPDVQGAGS--GLLLPLGVRRLQAFGP
Mflv_0405|M.gilvum_PYR-GCK GTEPMHPVLMDLCTGVAFPAFPALLAAEQGVNDLYLPLRYGQVSLQEKMP
Mvan_0269|M.vanbaalenii_PYR-1 GTEPMHPVLMDLCTGVAFPAFPALLAAEQGVSDLFLPLRYGQVTLRDKMP
...* :. * : * * :: .
Rv1527c|M.tuberculosis_H37Rv ARHARYCCTTVTACG-VGVEADLDVLDEHGAVVLAVRGLQLGTGASQASE
Mb1554c|M.bovis_AF2122/97 ARHARYCCTTVTACG-VGVEADLDVLDEHGAVVLAVRGLQLGTGASQASE
MMAR_2340|M.marinum_M TRNAHYCYARVTSVDTSAVEADLDVLDEHGTVLVAVRGLQLGTGVSEEGN
MAV_2370|M.avium_104 ARNAHYCYTRVTKADTSGVEADIDVLDEHGAVLLAVQGLRVGTSASESGT
MLBr_00139|M.leprae_Br4923 TRNARYCYTRLTKIEPRGGEADLDVLDEHGAVLLAVRGLHMGTGTTERGE
MUL_2010|M.ulcerans_Agy99 TRNAQYCYTRVTKADANGGEADLELLDEQGCVLLAVRGLRLGTGTSESGE
MSMEG_4727|M.smegmatis_MC2_155 TRNVRYCLSRIVKADSFGVEADLELLDADGTVLLSAMGLQLGTGNSDKAE
MAB_3148c|M.abscessus_ATCC_199 ARATQYCYTRVTKVVGNEVEADIDLLDETGSVLIAVRGFRFGTGSSDDEQ
TH_4621|M.thermoresistible__bu TRGARYCYARVTDADGSKAEADLDVLDEHGNVLLRVQGLLMGGAAADGDD
Mflv_0405|M.gilvum_PYR-GCK RRFYCRATWHEAPLDSETQVFDLEYLDRDGRHLGGVREFTVKRAPREALL
Mvan_0269|M.vanbaalenii_PYR-1 RRFYCRATWHTSELDSETQVFDLDFLDRDGRHLGGIREFTVKRAPREALL
* . *:: ** * : : . . :
Rv1527c|M.tuberculosis_H37Rv R--ARVLGERLLSIEWHERELPE---NSHAEPGAWLLIS---TCDATDLV
Mb1554c|M.bovis_AF2122/97 R--ARVLGERLLSIEWHERELPE---NSHAEPGAWLLIS---TCDATDLV
MMAR_2340|M.marinum_M R--DRVLNERLLTIEWQQRELPE---VDAAEAGAWLLIS---TSDGADML
MAV_2370|M.avium_104 R--DRVLTERLLNIEWRQRELPE---PEHADAASWLLIG---TTATADVL
MLBr_00139|M.leprae_Br4923 L--DRQLSERLLTIGWQQRTLPE---SVHVEPGSWLLIDTFNASAIPDMW
MUL_2010|M.ulcerans_Agy99 R--DRVLSERLLTLEWQQRQLPE---VLDEETGSWLLIS---ASDGEDLM
MSMEG_4727|M.smegmatis_MC2_155 E--ERLLDERLLTIEWQQRELPRPEGSETVDAGSWLVILAG--DDDENPR
MAB_3148c|M.abscessus_ATCC_199 R--DQLLNNRLLAIEWQQQRLPE---SVSGAPRRWLLVS---TGESVDPW
TH_4621|M.thermoresistible__bu R--DRVLGERLLTIEWQRRDLPE----ADSAAGKWLLVS---TSATADVS
Mflv_0405|M.gilvum_PYR-GCK RGLGGDATRLLYTLGWHEVPVPE-SGDGAAPQGTWLIGG-----------
Mvan_0269|M.vanbaalenii_PYR-1 RGLGGDATRLLYTLGWHEVPAPA-SGD-AALNGNWLIAG-----------
. * : *:. * **:
Rv1527c|M.tuberculosis_H37Rv AAQLTDALKV---HDAQCTTMSWPQ-RADHAAQAARLRDQLGTGGFTGVF
Mb1554c|M.bovis_AF2122/97 AAQLTDALKV---HDAQCTTMSWPQ-RADHAAQAARLRDQLGTGGFTGVF
MMAR_2340|M.marinum_M AAELTDALKL---HSAQCATTSWHENAADHAASAERLRNQLNAGGFHNAV
MAV_2370|M.avium_104 ASTLADTLKN---HGAQCTTMAWPQ-QADHTAHAEQLRNQWRGDGFTGVV
MLBr_00139|M.leprae_Br4923 ASTLTDALKSYGTQGTECTNLSWLI-QDDPVVSRERLGRQLRGRD--GVV
MUL_2010|M.ulcerans_Agy99 ATTLADALKS---QGAECASMVWSA-QDDLAGGIEKLGAQLRARTNKGVV
MSMEG_4727|M.smegmatis_MC2_155 AAGVVSALIG---AGMPTTTMAWSH-DADHDAQAAALTARLDEQPLAGVA
MAB_3148c|M.abscessus_ATCC_199 AAELIDSLKVR---ESEVSLIQWRP-NTDRVAALKLLYDQLESGTFDGVL
TH_4621|M.thermoresistible__bu ATRLSDALKQ---AGAESTSMCWPQ-QADHADNVDRFRAGI-ADGVTGVV
Mflv_0405|M.gilvum_PYR-GCK FDELAVSVPG-----------CIPADR-TNPESLRQLLTDAHGRGLPFSG
Mvan_0269|M.vanbaalenii_PYR-1 FDELAAGVPG-----------CIPFDRSTDPEPLGQLLAQAHERGIGFSG
: : :
Rv1527c|M.tuberculosis_H37Rv VLTAPQTGDPDAESP----VRGGELVKHVVRIAREIPEITAQEPRLYVLT
Mb1554c|M.bovis_AF2122/97 VLTAPQTGDPDAESP----VRGGELVKHVVRIAREIPEITAQEPRLYVLT
MMAR_2340|M.marinum_M ILLKPDSGDRDENSG----VEGVECVRHVVRVVRELPEIMGEAPRLFVVT
MAV_2370|M.avium_104 VLTGPKNGDNDQESA----LLSRDHVQHLVRIARELTDLPGEPPRLYVVT
MLBr_00139|M.leprae_Br4923 ILCGPRAGAPDEQSL----LAAREQVRHLVRIIRELAELEGELPRLFVVT
MUL_2010|M.ulcerans_Agy99 IVCGPRSGDADEQSL----LQGREQVRHLVRITRGLAELEGELPRLFVVT
MSMEG_4727|M.smegmatis_MC2_155 VIVGDSETGTDAHDVGADARRGADHVRHLVRIARTLADAVGEPPRLYVVT
MAB_3148c|M.abscessus_ATCC_199 VVTAPGSEGGADRVV----LQGADQVRHLVRITRELVDLPGEPPRLFVVT
TH_4621|M.thermoresistible__bu VLTGPKNGNPDDAAAR----RGSDYVRHLVRITRELAEIDGDAPRLFVVT
Mflv_0405|M.gilvum_PYR-GCK VVWRAARSDGDESDAEVAARLEAEIAELLGAVHTVQGGEVKLPGGLWIVT
Mvan_0269|M.vanbaalenii_PYR-1 VVWRAAAPSADESSTAMAARIETEIADLLSAVHTVQNGAVKLPGGLWIVT
:: : . : : *:::*
Rv1527c|M.tuberculosis_H37Rv HNAQAVLSGDRPNLEQGGMRGLLRVIGAEHPHLKASYVDVDEQTGAESVA
Mb1554c|M.bovis_AF2122/97 HNAQAVLSGDRPNLEQGGMRGLLRVIGAEHPHLKASYVDVDEQTGAESVA
MMAR_2340|M.marinum_M RGAQTVLGGESANLEQAGLRGLLRVIGAEYPHLHTTHVDVDEHSGSEVVA
MAV_2370|M.avium_104 RNAQTVLPNDVPNLGQAGLRGLVRVIGMEHPQLGAGQIDVDESTDAQALA
MLBr_00139|M.leprae_Br4923 RQAQIVQSGDAANLEQAGLRGLLRVISSEHPMLRTTLVDVDEHTDVERVA
MUL_2010|M.ulcerans_Agy99 RQAQRVRPEDEINLEQAGLRGLLRVIGSEHPLLQTTQVDVDESTQAEQLA
MSMEG_4727|M.smegmatis_MC2_155 HRSQHVLDTDEPYLEHSGLRGLIRVVGMEHPRLRATQIDVDDSTAHEALV
MAB_3148c|M.abscessus_ATCC_199 RNAQTVVDGDITNLEQAGLRGLVRVIGAEYPHLRVTHIDVDRHTAAQNVA
TH_4621|M.thermoresistible__bu RGAQAVLPQDRPNLEQAGLRGLLRVIGAEHPHLRTTQIDIADDADLDRVA
Mflv_0405|M.gilvum_PYR-GCK ERAVATESGEPVDPVQAALWGFGRTAINEEPALRCRLVDCDGSPQAVQAL
Mvan_0269|M.vanbaalenii_PYR-1 ERAVATESGEPVDPVQAALWGFGRTTINEEPALRCRLVDVDGSPEAVLAL
. : . : :..: *: *. * * * :* .
Rv1527c|M.tuberculosis_H37Rv RQLLAASGEDETAWRNDQWYTARLCPAPLRPEERQTTVVDHAEAGMRLQI
Mb1554c|M.bovis_AF2122/97 RQLLAASGEDETAWRNDQWYTARLCPAPLRPEERQTTVVDHAEAGMRLQI
MMAR_2340|M.marinum_M RQLLSGSEEDETAWRCGQWYTARLSPMPLRPEERKTTVVEHDTEGMRLQI
MAV_2370|M.avium_104 RQLLAGSEEDETAWRDGAWYTARLCPAPLLPEERHTAVANHECDGMRLQI
MLBr_00139|M.leprae_Br4923 QQLLSGSEEDETAWRNGDWYVARLNPSPLSHEDRRTVVLNPEHDGLRVHV
MUL_2010|M.ulcerans_Agy99 QQLLGGSEEDETAWRGGEWYVARLFPGPLSADERQTTVVDHERDNMRLQI
MSMEG_4727|M.smegmatis_MC2_155 RQLLSGSPEDETAWRDGQWYAARLCPSPLRAAERRTAVADNASEGMRLVV
MAB_3148c|M.abscessus_ATCC_199 GELVSGSEEDETAWREDHWYRARLNLGPLGPDDWRSTVATPNNEGVRFEV
TH_4621|M.thermoresistible__bu VQLLGGGAEDETAWRDGQWYTARLSLSPLRPEERKQAVVDCERDGMRLEI
Mflv_0405|M.gilvum_PYR-GCK AALLSTPVDE----PELAVRQGKLLASRLLPWSRSGHLTVPRGGDYVLAP
Mvan_0269|M.vanbaalenii_PYR-1 AGLLAAPVDE----PELAVRQGKLLASRLLPWARSGHLTVPRSADYVLAP
*:. :: .:* * : . .
Rv1527c|M.tuberculosis_H37Rv RTPGDLQTLEFAAFDRVPPGPGEIEVAVTASSINFADVLVTFGRYQTLDG
Mb1554c|M.bovis_AF2122/97 RTPGDLQTLEFAALDRVPPGPGEIEVAVTASSINFADVLVTFGRYQTLDG
MMAR_2340|M.marinum_M RTPGDLQTMEFVAFDRVAPGPGQIEVAVSTSSINFADVLVSFGRYNSPDG
MAV_2370|M.avium_104 RTPGDLESLELVACDRIPPGPGQIEVAVSASSINFADVLVAFGRYPAFEG
MLBr_00139|M.leprae_Br4923 RKPGDLQSLELVASDRVPPGPGQLEVAVSMSSINFADVLIAFGRFPIIDD
MUL_2010|M.ulcerans_Agy99 RTPGDLQTLELAACDRVPPGPGQIEVAVTMSSINFADVLIAFGRYPSLEG
MSMEG_4727|M.smegmatis_MC2_155 RNPGDLESMELVTFERGTPGPGQIEVAVKASSINFADVLVAFGRCPSFDG
MAB_3148c|M.abscessus_ATCC_199 RTPGDLQSLGFVAFDRVAPGPGQIEVSVTATSINFADVLNVYGRYSSFEG
TH_4621|M.thermoresistible__bu RTPGDLETMELAAFDRVPPGPGQIEVAVTASSINFADVLIAFGRYPTFDG
Mflv_0405|M.gilvum_PYR-GCK TERGAIDNLRLTDSEVPPPAEGYVQVRVEAAGLNFRDVLNVLGLYP---G
Mvan_0269|M.vanbaalenii_PYR-1 TERGAIDNLRLTETDVAPPAEGYVQVRVEAAGLNFRDVLNVLGLYP---G
* ::.: :. : .*. * ::* * :.:** *** * .
Rv1527c|M.tuberculosis_H37Rv RQPQLGTDFAGVVSAVGPGVSELKVGDRVGGMSPNGCWATFVTCDARLAT
Mb1554c|M.bovis_AF2122/97 RQPQLGTDFAGVVSAVGPGVSELKVGDRVGGMSPNGCWATFVTCDARLAT
MMAR_2340|M.marinum_M QMPQLGTDFAGVVTAVGPDVTDHQVGDRVGGMSPHGCWATFVTCDGALAT
MAV_2370|M.avium_104 RLPELGTDFAGVVTAVGPDVTDHKVGDHVGGLSANGCWGTFLTCDARLAV
MLBr_00139|M.leprae_Br4923 RDPQLGMDFVGVVTAVGEGVTGHQIGDRVGGFSEGGCWRTFLTCDANLAV
MUL_2010|M.ulcerans_Agy99 RLPETGTDFVGVVTAVGEGVTDHQVGDRVGGFSKDGCWRSYLTCDANLAV
MSMEG_4727|M.smegmatis_MC2_155 RLPELGSEFGGVVTAVGPGVTTHRVGDRVGGVSANGCWSNFVTCEADLAT
MAB_3148c|M.abscessus_ATCC_199 RQ-ELGVDFAGVVTAVGEGVTQHQVGDRVGGMTPTGAWRSFVVVDANLAA
TH_4621|M.thermoresistible__bu RRPQLGTDFAGVVTAVGPDVTSHRVGDRVGGLSPNGCWSTFVTCDADLAV
Mflv_0405|M.gilvum_PYR-GCK DPGPIGGDFAGTVTQLGEGVTGLDVGQRVYGSMQG-AFASRFNVPGQFLA
Mvan_0269|M.vanbaalenii_PYR-1 DPGPIGGDFAGTVTQLGSGVTGLEVGQRVYGFMQG-AFASRFNVPAQLLA
* :* *.*: :* .*: :*::* * .: . . . : .
Rv1527c|M.tuberculosis_H37Rv RLPEGLTDAQAAAVTTASATAWYGLQDLARIKAGDKVLIHSATGGVGQAA
Mb1554c|M.bovis_AF2122/97 RLPEGLTDAQAAAVTTASATAWYGLQDLARIKAGDKVLIHSATGGVGQAA
MMAR_2340|M.marinum_M PIPAGLTDAQAAAVTTAHATAWYGLHDLGRIRAGDKVLIHSGTGGVGQAA
MAV_2370|M.avium_104 TLPPGLADDQAAAVTTAHATAYYGLHELARIGAGDRVLIHSATGGVGQAA
MLBr_00139|M.leprae_Br4923 TLPSGLTDEQAITAATAHATAWYGLNDLAGIKVGDKVLIHSATGGVGQAA
MUL_2010|M.ulcerans_Agy99 TLPAGLSDEHAAASSTAHATAWYGLNDLAGIKAGDRVLIHSATGGVGQAA
MSMEG_4727|M.smegmatis_MC2_155 KLPEGISEHEAAAVGLAYGTVWLGLTELARMSAGDKILIHSATGGVGQAA
MAB_3148c|M.abscessus_ATCC_199 TLPAEVPDREAAAVPGAHVTAWYGLHELARISAGDKVLIHSGTGGVGQAA
TH_4621|M.thermoresistible__bu PLPDGLTEGQAAAVSTAHATAWYGLHDLARLGAGEKVLIHSATGGVGLAA
Mflv_0405|M.gilvum_PYR-GCK PIPDGVSAVEAATIPAAALTVRL-SFDWAQVKSGDKVLIHAASGGVGLAA
Mvan_0269|M.vanbaalenii_PYR-1 PIPDGIGAVDAATIPAAALTARL-AFDWAQLKPGDRVLIHAASGGVGLAA
:* : .* : * *. : . : *:::***:.:**** **
Rv1527c|M.tuberculosis_H37Rv IAIARAAGAQIYATAGNEKRRDLLRDMGIEHVYDSRSVEFAEQIRRDTAG
Mb1554c|M.bovis_AF2122/97 IAIARAAGAQIYATAGNEKRRDLLRDMGIEHVYDSRSVEFAEQIRRDTAG
MMAR_2340|M.marinum_M IAIARAAGAEIYATAGSPKRRQVLRDMGIEHVYDSRSIEFAEAIRADTDG
MAV_2370|M.avium_104 IAIARAAGAEIFATAGSEQRRQLLRDMGIEHVYDSRTVEFADLIRHDTDG
MLBr_00139|M.leprae_Br4923 ISIARAKGAEIFATAGNPTKRAMLHDLGIEHVYDSRSVEFAEQIRRDTDG
MUL_2010|M.ulcerans_Agy99 IAIARAAGAQIFATAGNAERRQLVNDMGIEHVYDSRSIEFADQIRRDTNG
MSMEG_4727|M.smegmatis_MC2_155 IAVARAAGAEIYATAGSEKRRQLLRDWGIEHVYDSRTTAFADQIRTDTDG
MAB_3148c|M.abscessus_ATCC_199 IAIARAAGAEIYATAGSPERRDLLRSWGIKHVYDSRSTDFAELIRRDTDG
TH_4621|M.thermoresistible__bu IAIARSVGAQIYATAGSPARRDLLRDMGIEHVYDSRSTAFADEIRRDTDG
Mflv_0405|M.gilvum_PYR-GCK VQMAQQCGAEVYATASTFKR-ATLRKLGVKHVYDSRTTDFAEQILADTDG
Mvan_0269|M.vanbaalenii_PYR-1 IQMAQQHGAVVFATASTYKR-ATLRKLGVDHVYDSRTTEFADQILADTDG
: :*: ** ::***.. : :.. *:.******: **: * ** *
Rv1527c|M.tuberculosis_H37Rv YGVDIVLNSVTGAAQLAG-LKLLALGGRFIEIGKRDIYSNTRLELLPFRR
Mb1554c|M.bovis_AF2122/97 YGVDIVLNSVTGAAQLAG-LKLLALGGRFIEIGKRDIYSNTRLELLPFRR
MMAR_2340|M.marinum_M YGVDIVLNSLTGAAQRAG-LELLAWGGRFVEIGKRDIYGDTKMGLFPFRR
MAV_2370|M.avium_104 YGVDIVLNSVTGAAQRAG-IELLAFGGRFVEIGKRDIYGDTRLGLLPFRR
MLBr_00139|M.leprae_Br4923 YGVDIVLNSLTGAAQRAG-LELLTFGGRFVEIGKADVYGNTRLGLFPFRR
MUL_2010|M.ulcerans_Agy99 YGVDIVLNSLTGAAQRAG-LELLAFGGRFVEIGKADVYGNTRMGLYPFRR
MSMEG_4727|M.smegmatis_MC2_155 YGVDIVLNSVTGPAQRAG-LELLAFGGRFVEIGKRDIYADTRLGLFPFRR
MAB_3148c|M.abscessus_ATCC_199 YGVDIVLNSLTGAAQRAG-VELLTFGGRFIEIGKRDIYGDTRLGLFPFRR
TH_4621|M.thermoresistible__bu YGVDVVLNSLPGAAQRAG-LELLSFGGRFIEIGKRDIYGDTRLGLFPFRR
Mflv_0405|M.gilvum_PYR-GCK AGVDVVLNSLTSEGFIEATLRATAQHGRFAEIAKRDIWTVEQMAAA--RP
Mvan_0269|M.vanbaalenii_PYR-1 EGVDVVLNSLTNEGFIEATVRATAQNGRFAEIAKRDIWTPEQMAAA--RP
***:****:.. . . :. : *** **.* *:: :: *
Rv1527c|M.tuberculosis_H37Rv NLAFYGLDLGLMSVSHPAAVRELLSTVYRLTVEG------VLPMPQSTHY
Mb1554c|M.bovis_AF2122/97 NLAFYGLDLGLMSVSHPAAVRELLSTVYRLTVEG------VLPMPQSTHY
MMAR_2340|M.marinum_M NLSFYGVDLGMLSITHPRLIRELLTTVYQHTAEG------VLPMPQDTHY
MAV_2370|M.avium_104 NLTFYALDLALMSFSHPDRLRGLLRTVYRLTADG------ALPMPESTHY
MLBr_00139|M.leprae_Br4923 GLTFYYLDLALMSVTQPDRVRELLATVFNLTADG------VLTAPECTHY
MUL_2010|M.ulcerans_Agy99 GLTFYYVDLGLMSVIQPERVRELLSTVYNLTAEG------VLSAPECTHY
MSMEG_4727|M.smegmatis_MC2_155 NLSFYAVDLALMTVTHPQKIRDLLATVYRLIADG------TLPLPEITHY
MAB_3148c|M.abscessus_ATCC_199 NLSFHAVDLVLVAKTRPEAIYRTLTALYGQMAEG------VLPLPEISPS
TH_4621|M.thermoresistible__bu NLAFHGVDLGLMADSHPHKIRELLETVYRLTADG------VLPMPQSTHY
Mflv_0405|M.gilvum_PYR-GCK DLAYEIVALDTVMFTEPDRIRDLLTEVSAGLRDG------AWTPLPAEVY
Mvan_0269|M.vanbaalenii_PYR-1 DIAYEIVALDTVTLLEPERIRGLLGEVSDGLGKADGSSRAEWVPLPAEIY
.::: : * : .* : * : ..
Rv1527c|M.tuberculosis_H37Rv PLAEAATAIRVMGAAEHTGKLILDVPHAGRSSVVLPPEQARVFRSDGSYI
Mb1554c|M.bovis_AF2122/97 PLAEAATAIRVMGAAEHTGKLILDVPHAGRSSVVLPPEQARVFRSDGSYI
MMAR_2340|M.marinum_M PLAEAATAIRVMGAADHTGKLLLDIPRSGRSAVVLPPEQVPVLRADGSYI
MAV_2370|M.avium_104 PLADAASAIRVMSAAQHTGKLVLDVPHAGRSRVVVPPAQVRAFRSDGAYI
MLBr_00139|M.leprae_Br4923 PLTDAANAIRAMSNAEHTGKLVLDIPRTGSRSVAVPPEQAPVYRRDGSYI
MUL_2010|M.ulcerans_Agy99 PLAEAAEAIRTMSNAAHTGKLLLDMPRSGRRGVVVPPEQVEVFRGDGSYI
MSMEG_4727|M.smegmatis_MC2_155 PLEEAATAIRIMGGAQHTGKLVIDIPDTGQSQVVVPPEQVPVFRGDGAYV
MAB_3148c|M.abscessus_ATCC_199 PLQEAAESIRVMGAAGHTGKLVLDLPKAGEVSAVIPPSHAPAFRRDGAYV
TH_4621|M.thermoresistible__bu PLAEAATAIRVMSAAEHVGKLVLDVPHTGRADVVVPPEQASPFRSDGAYI
Mflv_0405|M.gilvum_PYR-GCK PLTEARAAFRRMQQARHIGKIVVQIPNPLQP------------QPDRSYL
Mvan_0269|M.vanbaalenii_PYR-1 PLTEARAAFRRMQQARHVGKIVLQMPKPLQP------------RADRSYL
** :* ::* * * * **:::::* . : * :*:
Rv1527c|M.tuberculosis_H37Rv ITGGLGGLGLFLAEKMAN----AGAGRIVLSSRSQPSQKALETIELVRA-
Mb1554c|M.bovis_AF2122/97 ITGGLGGLGLFLAEKMAN----AGAGRIVLSSRSQPSQKALETIELVRA-
MMAR_2340|M.marinum_M ITGGLGGLGLFLAEKMAT----AGAGRIVLSSRSAPSQKALETIELIRS-
MAV_2370|M.avium_104 VTGGLGGLGLFLAEKMASPGSRAGCGRIVLCSRALPNPKALATLERIRQ-
MLBr_00139|M.leprae_Br4923 ITGGLGGLGLFFASKLAE----AGCGRIVLTARSQPNPKARQTIERLCA-
MUL_2010|M.ulcerans_Agy99 ITGGLGGLGLFFASKMAA----AGCGRIVLTARSQPNPKSRQAIERLRA-
MSMEG_4727|M.smegmatis_MC2_155 ITGGLGGLGLFLAERMAA----AGCGRIVVNSRSAPSTRSSEIIELIRA-
MAB_3148c|M.abscessus_ATCC_199 VTGGLGGLGLFLARKLAA----AGVGRIILNGRSAPKPEALAAIEQIRQ-
TH_4621|M.thermoresistible__bu VTGGMGGLGLYLAGEMAA----AGAGCIVLNGRSAPSGEALRTIEQLRA-
Mflv_0405|M.gilvum_PYR-GCK ITGGLGAIGLHTAGYLAQ----LGAGDIVLTSRRAPDAAAQQAIADIADR
Mvan_0269|M.vanbaalenii_PYR-1 ITGGLGAIGLHTAAYLAQ----LGAGDLVLTSRRAPDADARRAIEEITER
:***:*.:**. * :* * * ::: .* *. : : :
Rv1527c|M.tuberculosis_H37Rv IGSDVVVECGDIAQPDTADRLVTAATATGLPLRGVLHAAAVVEDATLANI
Mb1554c|M.bovis_AF2122/97 IGSDVVVECGDIAQPDTADRLVTAATATGLPLRGVLHAAAVVEDATLANI
MMAR_2340|M.marinum_M IGSDVVVECGDIAQPATAARLVANATATNLPLRGVLHAAAVVEDATLANI
MAV_2370|M.avium_104 MGADIVVERGDIAEAGTAQRLLDVATATGLPVRGVLHLAAVIEDATLANI
MLBr_00139|M.leprae_Br4923 AGADIVVECGNIAEPYTADRLVNAATATGLPLRGVLHSAAVVEDATLTNI
MUL_2010|M.ulcerans_Agy99 NGADIVVECGNIAEPETADRLVSAATATGLPLRGVLHAAAVVEDATLSNI
MSMEG_4727|M.smegmatis_MC2_155 TGADIVVECGDIAEPDTALRLVAAATQTGLPLRGVLHAAAVVEDATLANI
MAB_3148c|M.abscessus_ATCC_199 GGTEIDVALGDIAEPDTAQRLVAAATETGKPVRGVLHAAALVHDATLANI
TH_4621|M.thermoresistible__bu AGTEVIVECG----XXXRGQPVEVAVPT------ELRHADEHPDRRGAQL
Mflv_0405|M.gilvum_PYR-GCK TKARLHVFTADVGVEADVAALLERIRAELPPLAGVAHLAGVLDDALLSQQ
Mvan_0269|M.vanbaalenii_PYR-1 YKCRVHTFCADVGDESQVAELLARIRAELPPLAGVAHLAGVLDDALLSQQ
: . . : : * * ::
Rv1527c|M.tuberculosis_H37Rv TDELIER-DWAPKAYGAWQLHRAT-----ADQPLDWFCSFSSAAALVGSP
Mb1554c|M.bovis_AF2122/97 TDELIER-DWAPKAYGAWQLHRAT-----ADQPLDWFCSFSSAAALVGSP
MMAR_2340|M.marinum_M TDELLDR-DWAPKVYGAWHLHQAT-----TDQPLDWFCSFSSAAAMLGSP
MAV_2370|M.avium_104 TDELIER-DWAAKVYGAWNLHCALQESG-AEQSLDWFCSFSSAAALVGSP
MLBr_00139|M.leprae_Br4923 TDELIDR-DWSPKVYGSWNLHCAT-----IGQPLDWFCLFSSGAALLGSP
MUL_2010|M.ulcerans_Agy99 TDELIDR-DWSPKVYGSWNLHRAS-----TGQPLDWFCLFSSGAALMGSP
MSMEG_4727|M.smegmatis_MC2_155 TDELVEH-DWAPKVYGAWNLHQAVQSGGPATSELDWFCAFSSAAALVGSP
MAB_3148c|M.abscessus_ATCC_199 TDELIDRGDWRPKVHGAWNLHEAT-----ADQPLDWFCSFSSIAALVGSP
TH_4621|M.thermoresistible__bu CDEFARG------EQGAQRNQHRT------DAGEGQRDAHPPGAVGHDQP
Mflv_0405|M.gilvum_PYR-GCK SVERFRT-ALAPKAFGAVHLDRLT-----RVDDLDFFLVSSSVSSLFGSP
Mvan_0269|M.vanbaalenii_PYR-1 SLERFRT-TLAPKAFGACHLDRLT-----AGDDLDFFIMSSSVSSLFGSP
* *: . . . .. : ..*
Rv1527c|M.tuberculosis_H37Rv GQGAYAAANSWLDTFTHWRRAQDLPATSIAWGAWGQIGRAIAFAEQTGDA
Mb1554c|M.bovis_AF2122/97 GQGAYAAANSWLDTFTHWRRAQDLPATSIAWGAWGQIGRAIAFAEQTGDA
MMAR_2340|M.marinum_M GQGAYAAANSWLDAFTHWRHNQNQPATAIAWGPWAEIGRAIALAESSDAA
MAV_2370|M.avium_104 GQGAYAAANSWLDAFTRWRRARGLKATAIAWGAWAQIGRGAALADSADVA
MLBr_00139|M.leprae_Br4923 GQGAYAAANSWVDLFAHWRRAQGLPVSAIAWGAWGEVGRATFLAEGGEIM
MUL_2010|M.ulcerans_Agy99 GQGAYAAANSWVDAFAHWRRAQGLPVCAIGWGAWGEVGRATFLAEGGEIM
MSMEG_4727|M.smegmatis_MC2_155 GQGAYAAANSWLDAFMQWRRAQGLPATSIAWGAWGEIGRGTAMAEG-DNA
MAB_3148c|M.abscessus_ATCC_199 GQGAYAAANSWLDGFTHWRRAQGLPATVIAWGAWSEIGQGTHLAQNAEAA
TH_4621|M.thermoresistible__bu DPGALSDTG--LDERGGQFPGVGVQIPVADPG----VGIDHRGAVRVDSG
Mflv_0405|M.gilvum_PYR-GCK GQSNYATANAFLDGLVAQRRAQGLPATGVNFGPWARGGMASSEAAAANIS
Mvan_0269|M.vanbaalenii_PYR-1 GQANYATANALLDGLTAHRRARGLPATGVNFGPWAQGGMASSEAATANIG
. . : :. :* . * * *
Rv1527c|M.tuberculosis_H37Rv IA---PEEGAYAFETLLRHNRAYSGYAPVIGSPWLTAFAQHSPFAE----
Mb1554c|M.bovis_AF2122/97 IA---PEEGAYAFETLLRHNRAYSGYAPVIGSPWLTAFAQHSPFAE----
MMAR_2340|M.marinum_M IA---PDEGAYAFQTLLRHNRTYTGYAPIIGAPWVTAFAERSKFAE----
MAV_2370|M.avium_104 IT---PDEGAYAFEALLRHDRACTGYAPITGTPWLTAFAQRSPFAE----
MLBr_00139|M.leprae_Br4923 IT---PDEGAYAFEMLVRYDRPYSGYIPILGAPWLPDLVRRSPWAE----
MUL_2010|M.ulcerans_Agy99 IA---PDEGMYAFEQMLRHARTYTGYIPIIGAPWLADLVRRSPWAE----
MSMEG_4727|M.smegmatis_MC2_155 IA---PDEGAYAFEAILRHDRVYNGYAPVLGASWLTAFAQRSPFAE----
MAB_3148c|M.abscessus_ATCC_199 IL---PDEGAYAFDTVLRHNRAYTAYAPMAGISWLADFVERSPFAQ----
TH_4621|M.thermoresistible__bu VP---AQQGVDG--EVVRHRTLSS---------------VRSGRSS----
Mflv_0405|M.gilvum_PYR-GCK AQGLIPLEPSAALTAMAEVVANGTAQATVLKANWQRAAKVLGSSRPPILD
Mvan_0269|M.vanbaalenii_PYR-1 AQGLVPLEPSAALGALAEVLANGTGQAAVLKANWQRAAKVLGSSRPPILD
. : . : . . .
Rv1527c|M.tuberculosis_H37Rv -KFQSLGQNRSGTSKFLAELVDLPREEWPDRLRRLLSKQVG--LILRRTI
Mb1554c|M.bovis_AF2122/97 -KFQSLGQNRSGTSKFLAELVDLPREEWPDRLRRLLSKQVG--LILRRTI
MMAR_2340|M.marinum_M -AFKALEQGRSGSSKFRSELDALPLDEWPGQLRRMVAEQVS--LILRRTI
MAV_2370|M.avium_104 -AFRANGQSATGTSKLRAELEELPPEEWSTRLRRLISDQVS--LILRRNV
MLBr_00139|M.leprae_Br4923 -MFSSAGQGSRGPSKFRMELLALPQDEWSGRLRRLLVEQAS--VILRRTI
MUL_2010|M.ulcerans_Agy99 -MFQSSGQNTRGPSKFLAELKLLPQEEWAGRLRRLIAEQAS--VILRRTV
MSMEG_4727|M.smegmatis_MC2_155 -LFLADTQGASETRKLRSELAALPREEWPTHLRRLIAEQVG--LLLRRTV
MAB_3148c|M.abscessus_ATCC_199 -AFRDAGQNQTETNKFLDELRALPREEWPTRLRKLVAEQVG--LVLRRSI
TH_4621|M.thermoresistible__bu -RWTAPGSRCGSGRRYGGE-----------SCRRTTGPAAG--AAARRGR
Mflv_0405|M.gilvum_PYR-GCK LVLPSAVGEITGDSELLKQLQEIPVPQRAGFVTEFLQKEVQNFLRLAQPP
Mvan_0269|M.vanbaalenii_PYR-1 LVLPRPEGEVAGDSELLRQLQEIPVAQRAGFVTEFLQREVQNFLRLAQPP
. : . . :
Rv1527c|M.tuberculosis_H37Rv DTDRLLSEYGLDSLSSQELRARVEAETG--IRISATEIN--TTVRGLADL
Mb1554c|M.bovis_AF2122/97 DTDRLLSEYGLDSLSSQELRARVEAETG--IRISATEIN--TTVRGLADL
MMAR_2340|M.marinum_M DPDRQLSEYGLDSLGNLELRTRVQSETG--IRISSTDI---TTVRGLADH
MAV_2370|M.avium_104 DPDRPLPEYGLDSLGGLELLTRIQTETG--IRVSPADIAAIGTIRGLADL
MLBr_00139|M.leprae_Br4923 DADRSFIEYGLDSLGMLEMRTHIESETG--IRLTPKVIATNNTARALAQY
MUL_2010|M.ulcerans_Agy99 DADRPFVEYGLDSLGMLEMRTHIETETG--VRLSPKVIASHNTARALSQH
MSMEG_4727|M.smegmatis_MC2_155 DPDRPLSEYGLDSLGHLELRTRIETETG--VRVSAMDMT---TIRGLAQR
MAB_3148c|M.abscessus_ATCC_199 DPDRSLPDYGLDSLGNLEIRTRIQADTG--VRIGPADVS---TVRSLAAH
TH_4621|M.thermoresistible__bu TRRRRRPRRPPPPPDRVRHRAGPAHGPV--RR------------------
Mflv_0405|M.gilvum_PYR-GCK AATSRFLDLGTDSLMAIELRNRLHSQFGGAFTINATAVFDYPTIGGLAEY
Mvan_0269|M.vanbaalenii_PYR-1 AATSRFLDLGTDSLMAIELRNRLHSQFGGAFTINATAVFDYPTIGGLAEY
. .
Rv1527c|M.tuberculosis_H37Rv MCDKLAADRDAPAPA---------------------
Mb1554c|M.bovis_AF2122/97 MCDKLAADRDAPAPA---------------------
MMAR_2340|M.marinum_M LFAQLAPEEAAASSQ---------------------
MAV_2370|M.avium_104 LRDKLTPAGAAQAERV--------------------
MLBr_00139|M.leprae_Br4923 LADTLAEEEGVAAPAAMVSPETP-------------
MUL_2010|M.ulcerans_Agy99 LADTLAEEEAQPAAS---------------------
MSMEG_4727|M.smegmatis_MC2_155 LCEMLDTDDAVSAPS---------------------
MAB_3148c|M.abscessus_ATCC_199 IYDRLAEQESEVASS---------------------
TH_4621|M.thermoresistible__bu ------------------------------------
Mflv_0405|M.gilvum_PYR-GCK LVAQLPD-----AETPQAAPQSESEPGPDVTE----
Mvan_0269|M.vanbaalenii_PYR-1 LVGQLPDSDAAAGETPATETSPIDHNHPDREADSPG