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METSVTPIAVIGMGCRLPGGINSPDKLWESLLRGDNLVTEVPPDRWDVDDFYDPEPGVPGRSVSRWGGFL DDVAGFDAEFFGISEREATSIDPQQRLLLETSWEAIEQGGLDPASLAGSSTAVFTGLTHEDYLVLTTAAG GLASPYVVTGLNNSVASGRISHTLGLHGPAMTFDTACSSGLMAVHLACRSLHDGESDLALAGGCAVLLEP HASVAASAQGMLSSTGRCKSFAADADGFVRSEGCAMVLLKRLPDALRDGNRIFAMILGTATNQDGGTETL MMPSEDAQVAVYQAALAVAGVEPETIGVVEAHGTGTPIGDPIEYRSLARVYGAGTPCALGSAKSNMGHST ASAGTVGLIKAILSLRNGLVPPLLHFDRLSDDLTEIETGLFVPQEVTPWPVGGYNTPKRVAVSSFGMSGT NVHVIVEEAPSEACAPDVPETSPGTGDATVGRQLFMLSSTSIAALRETARQLATWVEEHQDSVVLSDLAY TLARGRAHRPVRTAVVAADLPELVEGLCEIADGDALYDAVVGHGDRGPVWVFSGQGSQWASMGVQLLANE PVFAATITKLEPVIAAESSFSVTEAITAPETVTGIDKVQPSVFAVQVALATTMEQTYGVRPGAVIGHSMG ESAAAVVAGALSLEDAARVICRRSKLMNRVAGSGAMGSVELPAKQVNSELMARGIDDVVISVVASPQSTV IGGATETVRDLIAQWEQRDVMAREVAVDVASHSSQVDPILDDLAAALADIAPMTPKVPYYSATLFDPREL PVCNGAYWVDNLRNTVQFAAAVQAAMEDGYRVFAELSPHPLLTHAVEQTARNLDMSVAALAGMRREQSMP YGLRGLLADLHSAGAALDFAALYPAGRLLDAPLPVWTHPRLFIDTDGQEQRAQGACTVTVHPLLGSHVRL LEEPERHIWQGDVGTAALSWLADHQVHNVAALPGAAYCEMALAAAVEVFGEAAEVRAIAFEQMLLLAAET PIDAIASVDAPGVINFVVQANQDGEKMRNATATLHAAEDDCPPPAYDIAALLEAHPNSVNGTDLRESFAE RGVQLGAAFAGLATAHTAEAESGTVLAEVALPASIRFQQSSYQIHPALLDACFQSVGAGVDATKVGSRAG LLLPLGVRSLRVYRPTRNARYCYTRLTKIEPRGGEADLDVLDEHGAVLLAVRGLHMGTGTTERGELDRQL SERLLTIGWQQRTLPESVHVEPGSWLLIDTFNASAIPDMWASTLTDALKSYGTQGTECTNLSWLIQDDPV VSRERLGRQLRGRDGVVILCGPRAGAPDEQSLLAAREQVRHLVRIIRELAELEGELPRLFVVTRQAQIVQ SGDAANLEQAGLRGLLRVISSEHPMLRTTLVDVDEHTDVERVAQQLLSGSEEDETAWRNGDWYVARLNPS PLSHEDRRTVVLNPEHDGLRVHVRKPGDLQSLELVASDRVPPGPGQLEVAVSMSSINFADVLIAFGRFPI IDDRDPQLGMDFVGVVTAVGEGVTGHQIGDRVGGFSEGGCWRTFLTCDANLAVTLPSGLTDEQAITAATA HATAWYGLNDLAGIKVGDKVLIHSATGGVGQAAISIARAKGAEIFATAGNPTKRAMLHDLGIEHVYDSRS VEFAEQIRRDTDGYGVDIVLNSLTGAAQRAGLELLTFGGRFVEIGKADVYGNTRLGLFPFRRGLTFYYLD LALMSVTQPDRVRELLATVFNLTADGVLTAPECTHYPLTDAANAIRAMSNAEHTGKLVLDIPRTGSRSVA VPPEQAPVYRRDGSYIITGGLGGLGLFFASKLAEAGCGRIVLTARSQPNPKARQTIERLCAAGADIVVEC GNIAEPYTADRLVNAATATGLPLRGVLHSAAVVEDATLTNITDELIDRDWSPKVYGSWNLHCATIGQPLD WFCLFSSGAALLGSPGQGAYAAANSWVDLFAHWRRAQGLPVSAIAWGAWGEVGRATFLAEGGEIMITPDE GAYAFEMLVRYDRPYSGYIPILGAPWLPDLVRRSPWAEMFSSAGQGSRGPSKFRMELLALPQDEWSGRLR RLLVEQASVILRRTIDADRSFIEYGLDSLGMLEMRTHIESETGIRLTPKVIATNNTARALAQYLADTLAE EEGVAAPAAMVSPETP
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. leprae Br4923 | MLBr_00139 | mas | - | 100% (2116) | putative mycocerosic synthase |
M. leprae Br4923 | MLBr_01229 | pks3 | 0.0 | 60.00% (2130) | mycocerosic acid synthase (polyketide synthase) |
M. leprae Br4923 | MLBr_02355 | - | 0.0 | 38.48% (2165) | polyketide synthase |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb2965c | mas | 0.0 | 87.87% (2118) | multifunctional mycocerosic acid synthase membrane-associated |
M. gilvum PYR-GCK | Mflv_0405 | - | 0.0 | 33.71% (2186) | beta-ketoacyl synthase |
M. tuberculosis H37Rv | Rv2940c | mas | 0.0 | 87.91% (2118) | multifunctional mycocerosic acid synthase membrane-associated |
M. abscessus ATCC 19977 | MAB_3148c | - | 0.0 | 58.87% (2098) | polyketide synthase Pks5 |
M. marinum M | MMAR_1767 | mas | 0.0 | 75.89% (2115) | multifunctional mycocerosic acid synthase membrane-associated |
M. avium 104 | MAV_2370 | - | 0.0 | 64.07% (2104) | mycocerosic acid synthase |
M. smegmatis MC2 155 | MSMEG_4727 | - | 0.0 | 59.94% (2127) | mycocerosic acid synthase |
M. thermoresistible (build 8) | TH_4621 | - | 0.0 | 63.83% (1822) | PUTATIVE mycocerosic acid synthase |
M. ulcerans Agy99 | MUL_2010 | mas | 0.0 | 75.79% (2115) | multifunctional mycocerosic acid synthase membrane-associated |
M. vanbaalenii PYR-1 | Mvan_0269 | - | 0.0 | 34.40% (2183) | beta-ketoacyl synthase |
CLUSTAL 2.0.9 multiple sequence alignment Mb2965c|M.bovis_AF2122/97 -------------------------------------------------- Rv2940c|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00139|M.leprae_Br4923 -------------------------------------------------- MMAR_1767|M.marinum_M -------------------------------------------------- MUL_2010|M.ulcerans_Agy99 -------------------------------------------------- MAV_2370|M.avium_104 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- MSMEG_4727|M.smegmatis_MC2_155 -------------------------------------------------- MAB_3148c|M.abscessus_ATCC_199 -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK MGSAAHQGESAHRFAIVGYAGRFPGARDAESFWELLADGRDAISEVPEDR Mvan_0269|M.vanbaalenii_PYR-1 MGSAEHPNGPAPRFAIVGYAARFPGAPDADAFWDVLREGRDAISDVPRDR Mb2965c|M.bovis_AF2122/97 -------------------------------------------------- Rv2940c|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00139|M.leprae_Br4923 -------------------------------------------------- MMAR_1767|M.marinum_M -------------------------------------------------- MUL_2010|M.ulcerans_Agy99 -------------------------------------------------- MAV_2370|M.avium_104 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- MSMEG_4727|M.smegmatis_MC2_155 -------------------------------------------------- MAB_3148c|M.abscessus_ATCC_199 -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK WDVEAFFDPDPSTPGKVVTRRAGFVDDVSGFDAPFFGMSTREVRLMDPQH Mvan_0269|M.vanbaalenii_PYR-1 WDAEEFFDPEPGAPGKVVTRRAGFVDDVTGFDAPFFGMSTREVRMMDPQH Mb2965c|M.bovis_AF2122/97 -------------------------------------------------- Rv2940c|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00139|M.leprae_Br4923 -------------------------------------------------- MMAR_1767|M.marinum_M -------------------------------------------------- MUL_2010|M.ulcerans_Agy99 -------------------------------------------------- MAV_2370|M.avium_104 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- MSMEG_4727|M.smegmatis_MC2_155 -------------------------------------------------- MAB_3148c|M.abscessus_ATCC_199 -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK RLLLETAWRAIEHSGTAPSELANTNTGVFVGLATHDYLGMASDELSYPEI Mvan_0269|M.vanbaalenii_PYR-1 RLLLETAWRAVEHSGTAPTALAGSNTGVFVGLATHDYLGMASDELTYPEI Mb2965c|M.bovis_AF2122/97 -------------------------------------------------- Rv2940c|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00139|M.leprae_Br4923 -------------------------------------------------- MMAR_1767|M.marinum_M -------------------------------------------------- MUL_2010|M.ulcerans_Agy99 -------------------------------------------------- MAV_2370|M.avium_104 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- MSMEG_4727|M.smegmatis_MC2_155 -------------------------------------------------- MAB_3148c|M.abscessus_ATCC_199 -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK EAYMAIGTSNAAAAGRISYRLGLQGPAVAVDTACSSSLVAIHQACQALRL Mvan_0269|M.vanbaalenii_PYR-1 EAYMAIGTSNAAAAGRISYRLGLQGPAVAVDTACSSSLVAIHQACQALRL Mb2965c|M.bovis_AF2122/97 -------------------------------------------------- Rv2940c|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00139|M.leprae_Br4923 -------------------------------------------------- MMAR_1767|M.marinum_M -------------------------------------------------- MUL_2010|M.ulcerans_Agy99 -------------------------------------------------- MAV_2370|M.avium_104 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- MSMEG_4727|M.smegmatis_MC2_155 -------------------------------------------------- MAB_3148c|M.abscessus_ATCC_199 -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK GECDLALAGGANVILTPATMITFSNAHMLAPDGRCKTFDAAADGYVRGEG Mvan_0269|M.vanbaalenii_PYR-1 GECDLALAGGANVLLTPATMITFSNAHMLAPDGRCKTFDAAADGYVRGEG Mb2965c|M.bovis_AF2122/97 -------------------------------------------------- Rv2940c|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00139|M.leprae_Br4923 -------------------------------------------------- MMAR_1767|M.marinum_M -------------------------------------------------- MUL_2010|M.ulcerans_Agy99 -------------------------------------------------- MAV_2370|M.avium_104 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- MSMEG_4727|M.smegmatis_MC2_155 -------------------------------------------------- MAB_3148c|M.abscessus_ATCC_199 -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK CGVIVIKRLEDAVRDGDRIRAVIRGSAINQDGASGGLTVPNGVAQQRVIG Mvan_0269|M.vanbaalenii_PYR-1 CGVIVIKRLEDAVRDGDRIRAVIRGSSINQDGASGGLTVPNGVAQQRVIA Mb2965c|M.bovis_AF2122/97 -------------------------------------------------- Rv2940c|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00139|M.leprae_Br4923 -------------------------------------------------- MMAR_1767|M.marinum_M -------------------------------------------------- MUL_2010|M.ulcerans_Agy99 -------------------------------------------------- MAV_2370|M.avium_104 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- MSMEG_4727|M.smegmatis_MC2_155 -------------------------------------------------- MAB_3148c|M.abscessus_ATCC_199 -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK DALSRAGLAPGDVDYLEAHGTGTSLGDPIEAQAAGAALGPGREPQRPLLI Mvan_0269|M.vanbaalenii_PYR-1 DALKRSDLEPKDVGYLEAHGTGTSLGDPIEAQAAGAVLGAGREPSRPLLI Mb2965c|M.bovis_AF2122/97 -------------------------------------------------- Rv2940c|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00139|M.leprae_Br4923 -------------------------------------------------- MMAR_1767|M.marinum_M -------------------------------------------------- MUL_2010|M.ulcerans_Agy99 -------------------------------------------------- MAV_2370|M.avium_104 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- MSMEG_4727|M.smegmatis_MC2_155 -------------------------------------------------- MAB_3148c|M.abscessus_ATCC_199 -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK GSAKTNIGHLEAAAGIAGVIKVVLSLEHETLPKHLNFENPSPHIPWDRLP Mvan_0269|M.vanbaalenii_PYR-1 GSAKTNIGHLEAAAGIAGVIKVILSLEHRTLPKHLNFENPSPHIPWDRLA Mb2965c|M.bovis_AF2122/97 -------------------------------------------------- Rv2940c|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00139|M.leprae_Br4923 -------------------------------------------------- MMAR_1767|M.marinum_M -------------------------------------------------- MUL_2010|M.ulcerans_Agy99 -------------------------------------------------- MAV_2370|M.avium_104 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- MSMEG_4727|M.smegmatis_MC2_155 -------------------------------------------------- MAB_3148c|M.abscessus_ATCC_199 -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK VEVVKESIPWRRGQRGGRPRIAGVSSFGFAGTNAHVILEEAP-LAAEPAQ Mvan_0269|M.vanbaalenii_PYR-1 VEVVKETIPWER---DGGPRIAGVSSFGFAGTNAHVILEEAPEQAAAPGP Mb2965c|M.bovis_AF2122/97 -------------------------------------------------- Rv2940c|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00139|M.leprae_Br4923 -------------------------------------------------- MMAR_1767|M.marinum_M -------------------------------------------------- MUL_2010|M.ulcerans_Agy99 -------------------------------------------------- MAV_2370|M.avium_104 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- MSMEG_4727|M.smegmatis_MC2_155 -------------------------------------------------- MAB_3148c|M.abscessus_ATCC_199 -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK ESVDDGRFTLLPLSARTPAALMAVADRYRDWLVANPDATLADLCFTAGTA Mvan_0269|M.vanbaalenii_PYR-1 VQQPDRRFSLLPLSARTPAALTQLAGQYRDWWTAHPEATLADVCFTAGAG Mb2965c|M.bovis_AF2122/97 -------------------------------------------------- Rv2940c|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00139|M.leprae_Br4923 -------------------------------------------------- MMAR_1767|M.marinum_M -------------------------------------------------- MUL_2010|M.ulcerans_Agy99 -------------------------------------------------- MAV_2370|M.avium_104 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- MSMEG_4727|M.smegmatis_MC2_155 -------------------------------------------------- MAB_3148c|M.abscessus_ATCC_199 -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK RSHLEHRAALVVNTREAALDLLGALADDRPAPGLVRGESHDTPKTAWLFT Mvan_0269|M.vanbaalenii_PYR-1 RAHLEHRAALVVNSAESAVELLGALADDRPAPGLVRGESHDTPKTAWLFT Mb2965c|M.bovis_AF2122/97 -------------------------------------------------- Rv2940c|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00139|M.leprae_Br4923 -------------------------------------------------- MMAR_1767|M.marinum_M -------------------------------------------------- MUL_2010|M.ulcerans_Agy99 -------------------------------------------------- MAV_2370|M.avium_104 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- MSMEG_4727|M.smegmatis_MC2_155 -------------------------------------------------- MAB_3148c|M.abscessus_ATCC_199 -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK GQGSQYPGMSRELFDTEPLFAETLRECAAAVDGMLEKPLLDVIFDTDGVL Mvan_0269|M.vanbaalenii_PYR-1 GQGSQYPGMARELYDTEPVFAETLNRCAEAVADVLEKPLLDVIFDAE--- Mb2965c|M.bovis_AF2122/97 -------------------------------------------------- Rv2940c|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00139|M.leprae_Br4923 -------------------------------------------------- MMAR_1767|M.marinum_M -------------------------------------------------- MUL_2010|M.ulcerans_Agy99 -------------------------------------------------- MAV_2370|M.avium_104 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- MSMEG_4727|M.smegmatis_MC2_155 -------------------------------------------------- MAB_3148c|M.abscessus_ATCC_199 -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK DTDSNETLRHTSYAQPALFAVEMGLARLWQSWGFEPDVVLGHSVGQYAAA Mvan_0269|M.vanbaalenii_PYR-1 ADDAEKTLQNTCYAQPALFAVEMGLARLWQSWGFEPDVVLGHSVGQYSAA Mb2965c|M.bovis_AF2122/97 -------------------------------------------------- Rv2940c|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00139|M.leprae_Br4923 -------------------------------------------------- MMAR_1767|M.marinum_M -------------------------------------------------- MUL_2010|M.ulcerans_Agy99 -------------------------------------------------- MAV_2370|M.avium_104 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- MSMEG_4727|M.smegmatis_MC2_155 -------------------------------------------------- MAB_3148c|M.abscessus_ATCC_199 -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK CVAGVLSLRDGARLMAERGRLFGSLPSGGRMAAVFAAAERVEALTDEYPA Mvan_0269|M.vanbaalenii_PYR-1 CVAGVFSLTDGARLMAERGRLFGSLPEGGRMVAVFTTAERAEAMTDEFPS Mb2965c|M.bovis_AF2122/97 -------------------------------------------------- Rv2940c|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00139|M.leprae_Br4923 -------------------------------------------------- MMAR_1767|M.marinum_M -------------------------------------------------- MUL_2010|M.ulcerans_Agy99 -------------------------------------------------- MAV_2370|M.avium_104 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- MSMEG_4727|M.smegmatis_MC2_155 -------------------------------------------------- MAB_3148c|M.abscessus_ATCC_199 -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK LSVAAYNGANTVLSGPATDLERAVAGLVADGVRCDWLETSHAFHSALLDP Mvan_0269|M.vanbaalenii_PYR-1 LSVAAYNGTNTVLSGPAGDLEKAVATLSADGVRCDWLDTSHAFHSALLDP Mb2965c|M.bovis_AF2122/97 -------------------------------------------------- Rv2940c|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00139|M.leprae_Br4923 -------------------------------------------------- MMAR_1767|M.marinum_M -------------------------------------------------- MUL_2010|M.ulcerans_Agy99 -------------------------------------------------- MAV_2370|M.avium_104 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- MSMEG_4727|M.smegmatis_MC2_155 -------------------------------------------------- MAB_3148c|M.abscessus_ATCC_199 -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK ILDDFESYARGITFTAPQRILIDNRTGAALGRSVTLDAAYWRRHARQPVE Mvan_0269|M.vanbaalenii_PYR-1 ILDDFESYANQFDFAAPQRILIDNRTGTALGRSVQLDGTYWRRHARQPVE Mb2965c|M.bovis_AF2122/97 -------------------------------------------------- Rv2940c|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00139|M.leprae_Br4923 -------------------------------------------------- MMAR_1767|M.marinum_M -------------------------------------------------- MUL_2010|M.ulcerans_Agy99 -------------------------------------------------- MAV_2370|M.avium_104 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- MSMEG_4727|M.smegmatis_MC2_155 -------------------------------------------------- MAB_3148c|M.abscessus_ATCC_199 -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK FAKSVHTLADMNCKLLVEIGPRPVLTAAALSAWPDPATSPRVIASLRRTT Mvan_0269|M.vanbaalenii_PYR-1 FAKSVRTLAEMNCKLLVEIGPRPVLTAAALGAWPDPATAPRVIASLRRTA Mb2965c|M.bovis_AF2122/97 -------------------------------------------------- Rv2940c|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00139|M.leprae_Br4923 -------------------------------------------------- MMAR_1767|M.marinum_M -------------------------------------------------- MUL_2010|M.ulcerans_Agy99 -------------------------------------------------- MAV_2370|M.avium_104 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- MSMEG_4727|M.smegmatis_MC2_155 -------------------------------------------------- MAB_3148c|M.abscessus_ATCC_199 -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK ADQRQITEAVADAYVLGHLPRFAAFRRDGARVLDLPTYPFEHRQYWFSDS Mvan_0269|M.vanbaalenii_PYR-1 ADHRQITEAVADAYVLGHLPEFGAFRDAGARKLDLPTYPFEHRQYWFRDN Mb2965c|M.bovis_AF2122/97 -------------------------------------------------- Rv2940c|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00139|M.leprae_Br4923 -------------------------------------------------- MMAR_1767|M.marinum_M -------------------------------------------------- MUL_2010|M.ulcerans_Agy99 -------------------------------------------------- MAV_2370|M.avium_104 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- MSMEG_4727|M.smegmatis_MC2_155 -------------------------------------------------- MAB_3148c|M.abscessus_ATCC_199 -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK REP--VAAAPQRGARTETVRLLEDGRIEELAALLGGTVDDPFTFDVLNRL Mvan_0269|M.vanbaalenii_PYR-1 QDPDGSEALQPRTPSTEAVRLLEDGRIEELATLLDGAAGDQQTLDVLSRL Mb2965c|M.bovis_AF2122/97 -------------------------------------------------- Rv2940c|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00139|M.leprae_Br4923 -------------------------------------------------- MMAR_1767|M.marinum_M -------------------------------------------------- MUL_2010|M.ulcerans_Agy99 -------------------------------------------------- MAV_2370|M.avium_104 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- MSMEG_4727|M.smegmatis_MC2_155 -------------------------------------------------- MAB_3148c|M.abscessus_ATCC_199 -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK AAQHNQQRSTESIADDRYQIRWETAAEPPVGADAADGITWLLVGDDTDAT Mvan_0269|M.vanbaalenii_PYR-1 AAQHNQQRSSQSITNDRYEIRWEQSAAALSGAETDEVSSWILVGDDTEAT Mb2965c|M.bovis_AF2122/97 -------------------------------------------------- Rv2940c|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00139|M.leprae_Br4923 -------------------------------------------------- MMAR_1767|M.marinum_M -------------------------------------------------- MUL_2010|M.ulcerans_Agy99 -------------------------------------------------- MAV_2370|M.avium_104 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- MSMEG_4727|M.smegmatis_MC2_155 -------------------------------------------------- MAB_3148c|M.abscessus_ATCC_199 -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK RPLVDVLAARGHRYRILGLPKSGAEEHELADTLRDAAADATDLRIVHVAA Mvan_0269|M.vanbaalenii_PYR-1 RPLVDVLSARGQRYRIFGLPVSDADEEQLGEALRLAAAEDSTLRIVHVGG Mb2965c|M.bovis_AF2122/97 -------------------------------------------------- Rv2940c|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00139|M.leprae_Br4923 -------------------------------------------------- MMAR_1767|M.marinum_M -------------------------------------------------- MUL_2010|M.ulcerans_Agy99 -------------------------------------------------- MAV_2370|M.avium_104 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- MSMEG_4727|M.smegmatis_MC2_155 -------------------------------------------------- MAB_3148c|M.abscessus_ATCC_199 -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK LDAAES---DTSMKSLLRMQHRVLGGTRRLFGAAVAAQLRSPMWLVTRGA Mvan_0269|M.vanbaalenii_PYR-1 LDSDPDPGTAPSMRSLLRMQHRILGGTRRLFRAAAAAELRTPIWVVTRRA Mb2965c|M.bovis_AF2122/97 -------------------------------------------------- Rv2940c|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00139|M.leprae_Br4923 -------------------------------------------------- MMAR_1767|M.marinum_M -------------------------------------------------- MUL_2010|M.ulcerans_Agy99 -------------------------------------------------- MAV_2370|M.avium_104 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- MSMEG_4727|M.smegmatis_MC2_155 -------------------------------------------------- MAB_3148c|M.abscessus_ATCC_199 -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK QHVTDTDVVAPDQTCLWGFGRAASLEHPQIWGGLADLGGGTSDEWSRLLN Mvan_0269|M.vanbaalenii_PYR-1 QHVTATDTVAPDQSCLWGFGRAAALELPQLWGGLADLADGTADEWSRLLN Mb2965c|M.bovis_AF2122/97 -------------------------------------------------- Rv2940c|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00139|M.leprae_Br4923 -------------------------------------------------- MMAR_1767|M.marinum_M -------------------------------------------------- MUL_2010|M.ulcerans_Agy99 -------------------------------------------------- MAV_2370|M.avium_104 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- MSMEG_4727|M.smegmatis_MC2_155 -------------------------------------------------- MAB_3148c|M.abscessus_ATCC_199 -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK RIAATHDPAVMEDQVAVRGSTSYVPRLVHRDTLPSGKPLHLRADATYLVT Mvan_0269|M.vanbaalenii_PYR-1 RITAPHGPAVREDQIALRDHAVYVPRLVRRAGRPAGKPLQLRDDATYLVT Mb2965c|M.bovis_AF2122/97 -------------------------------------------------- Rv2940c|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00139|M.leprae_Br4923 -------------------------------------------------- MMAR_1767|M.marinum_M -------------------------------------------------- MUL_2010|M.ulcerans_Agy99 -------------------------------------------------- MAV_2370|M.avium_104 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- MSMEG_4727|M.smegmatis_MC2_155 -------------------------------------------------- MAB_3148c|M.abscessus_ATCC_199 -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK GGLGSLGLEIAGYLAANGAGHLVLTSRRTPDEAAASRIEALRERHGCEVR Mvan_0269|M.vanbaalenii_PYR-1 GGLGSIGLEIAGYLAAHGARHLVLTSRRAPGDATQQRIDALGAQHSCQIR Mb2965c|M.bovis_AF2122/97 -------------------------------------------------- Rv2940c|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00139|M.leprae_Br4923 -------------------------------------------------- MMAR_1767|M.marinum_M -------------------------------------------------- MUL_2010|M.ulcerans_Agy99 -------------------------------------------------- MAV_2370|M.avium_104 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- MSMEG_4727|M.smegmatis_MC2_155 -------------------------------------------------- MAB_3148c|M.abscessus_ATCC_199 -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK VVTADVADAHAVARLLATVQAEMPPLAGIVHAAGEIGTTPLADLDDAEVD Mvan_0269|M.vanbaalenii_PYR-1 VVAADVADAHDVARLLAAVAAELPPLAGIVHAAGEIGTTPLVSLEDSEVD Mb2965c|M.bovis_AF2122/97 -------------------------------------------------- Rv2940c|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00139|M.leprae_Br4923 -------------------------------------------------- MMAR_1767|M.marinum_M -------------------------------------------------- MUL_2010|M.ulcerans_Agy99 -------------------------------------------------- MAV_2370|M.avium_104 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- MSMEG_4727|M.smegmatis_MC2_155 -------------------------------------------------- MAB_3148c|M.abscessus_ATCC_199 -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK RVFAGKVWGAWHLSEATSDLQLDFFISTSSIASVWGGFGQAAYGAANAFL Mvan_0269|M.vanbaalenii_PYR-1 RVFAGKVWGAWHLSEAAADLQLDFFLGTSSIASVWGGYGQTAYGAANAFL Mb2965c|M.bovis_AF2122/97 -------------------------------------------------- Rv2940c|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00139|M.leprae_Br4923 -------------------------------------------------- MMAR_1767|M.marinum_M -------------------------------------------------- MUL_2010|M.ulcerans_Agy99 -------------------------------------------------- MAV_2370|M.avium_104 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- MSMEG_4727|M.smegmatis_MC2_155 -------------------------------------------------- MAB_3148c|M.abscessus_ATCC_199 -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK DGLAWRLREQGVAGVSVNFGPWSAGMADAQSRARLEQRGIKTLSPADALA Mvan_0269|M.vanbaalenii_PYR-1 DGLAWRLREQGISGVSINFGPWSAGMADAESRARLDQRGVRTLSPADALA Mb2965c|M.bovis_AF2122/97 -------------------------------------------------- Rv2940c|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00139|M.leprae_Br4923 -------------------------------------------------- MMAR_1767|M.marinum_M -------------------------------------------------- MUL_2010|M.ulcerans_Agy99 -------------------------------------------------- MAV_2370|M.avium_104 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- MSMEG_4727|M.smegmatis_MC2_155 -------------------------------------------------- MAB_3148c|M.abscessus_ATCC_199 -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK GLSDAVISAAP----HPVVARVDWSRFLPLYQQAGRRGFLAELERELPAA Mvan_0269|M.vanbaalenii_PYR-1 GLADVVTAAEAPGPAQGIVARIDWERFLPLYQQAGRRAFLAELEREVPDT Mb2965c|M.bovis_AF2122/97 -------------------------------------------------- Rv2940c|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00139|M.leprae_Br4923 -------------------------------------------------- MMAR_1767|M.marinum_M -------------------------------------------------- MUL_2010|M.ulcerans_Agy99 -------------------------------------------------- MAV_2370|M.avium_104 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- MSMEG_4727|M.smegmatis_MC2_155 -------------------------------------------------- MAB_3148c|M.abscessus_ATCC_199 -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK PAQQGPAVTASGRTPLVERLTTAPLQQRKRLLTDYLRDAVAEVTRVDAAE Mvan_0269|M.vanbaalenii_PYR-1 ----APAATPSGRTELVERLTNAPVQQRKKLLTDYLRTAVAEITRVDATE Mb2965c|M.bovis_AF2122/97 -------------------------------------------------- Rv2940c|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00139|M.leprae_Br4923 -------------------------------------------------- MMAR_1767|M.marinum_M -------------------------------------------------- MUL_2010|M.ulcerans_Agy99 -------------------------------------------------- MAV_2370|M.avium_104 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- MSMEG_4727|M.smegmatis_MC2_155 -------------------------------------------------- MAB_3148c|M.abscessus_ATCC_199 -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK IREDAGFFDLGMDSLMAVELRRRIETGVGKEIPVTLVMDHPRLSDAADYL Mvan_0269|M.vanbaalenii_PYR-1 IREDAGFFDLGMDSLMAVELRRRIEQGVGREIPATLAMDHPRLSDVADYL Mb2965c|M.bovis_AF2122/97 -----------------------MESRVTPVAVIGMGCRLPGGINSPDKL Rv2940c|M.tuberculosis_H37Rv -----------------------MESRVTPVAVIGMGCRLPGGINSPDKL MLBr_00139|M.leprae_Br4923 -----------------------METSVTPIAVIGMGCRLPGGINSPDKL MMAR_1767|M.marinum_M -----------------------MQKPATPVAIIGMGCRLPGGVDSPEKL MUL_2010|M.ulcerans_Agy99 -----------------------MQKSATPVAIIGMGCRLPGGVDSPEKL MAV_2370|M.avium_104 ---------------------------MVPVAVIGMACRLPGAVDSPERL TH_4621|M.thermoresistible__bu -------------------VNIVGDTPVNAVAVIGMACRLPGGIDSPQRL MSMEG_4727|M.smegmatis_MC2_155 ----------------------MTQNCVAPVAIIGMACRLPGAINSPQQL MAB_3148c|M.abscessus_ATCC_199 -----------------------------------MGCRLPGGIESPEQF Mflv_0405|M.gilvum_PYR-GCK LGDVLGLTEAATAPKAATVVSTAA---DEPIAIVAVSCRFPGAPN-PEAF Mvan_0269|M.vanbaalenii_PYR-1 LGEVLGLAEQAPAKAGSQPASAAANRTDEPIAIVAVSCRFPGAPD-PEAF :.**:**. : *: : Mb2965c|M.bovis_AF2122/97 WESLLRGDDLVTEIPPDRWDADDYYDPEPGVPGRSVSRWGGFLDDVAGFD Rv2940c|M.tuberculosis_H37Rv WESLLRGDDLVTEIPPDRWDADDYYDPEPGVPGRSVSRWGGFLDDVAGFD MLBr_00139|M.leprae_Br4923 WESLLRGDNLVTEVPPDRWDVDDFYDPEPGVPGRSVSRWGGFLDDVAGFD MMAR_1767|M.marinum_M WESLLRGDDLVSEIPPDRWDVDDYYDPEPGVPGRTVSRWGGFIDDVAGFD MUL_2010|M.ulcerans_Agy99 WESLLRGDDLVSEIPPDRWDVDDYYDPEPGVPGRTVSRWGGFIDDVAGFD MAV_2370|M.avium_104 WEALLRGDDFVTEIPPDRWDADEYYDPEPGVPGRSVSRWGAFIDDVAGFD TH_4621|M.thermoresistible__bu WEALLRGDDMVTEIPVDRWDADDYFDPEPGVPGRTVSRWGAFLDDVAGFD MSMEG_4727|M.smegmatis_MC2_155 WEALLRGDDFVTEIPTGRWDAEEYYDPEPGVPGRSVSKWGAFLDDPAAFD MAB_3148c|M.abscessus_ATCC_199 WQALLRGEDFITEVPPARWDLTEYYDPESGVPGKSPSKWGAFLEDVGGFD Mflv_0405|M.gilvum_PYR-GCK WDLLSGGVDAIREVPEDRFDIDEFYDPDPDAAGKTYTRYGGFLDHIDEFD Mvan_0269|M.vanbaalenii_PYR-1 WEVLAGGVDAIREVPEDRFDIDEFYDPDPDAAGKTYTRFGGFLDGIDGFD *: * * : : *:* *:* :::**:....*:: :::*.*:: ** Mb2965c|M.bovis_AF2122/97 AEFFGISEREATSIDPQQRLLLETSWEAIEHAGLDPASLAGSSTAVFTGL Rv2940c|M.tuberculosis_H37Rv AEFFGISEREATSIDPQQRLLLETSWEAIEHAGLDPASLAGSSTAVFTGL MLBr_00139|M.leprae_Br4923 AEFFGISEREATSIDPQQRLLLETSWEAIEQGGLDPASLAGSSTAVFTGL MMAR_1767|M.marinum_M AEFFGVSEREATSIDPQHRQLLETAWEAIEHAGLDPASLSGSSTGVFVGL MUL_2010|M.ulcerans_Agy99 AEFFGVSEREATSIDPQHRQLLETAWEAIEHAGLDPASLSGSSTGVFVGL MAV_2370|M.avium_104 PEFFGINEREATAMDPQHRLLLETSWEAMEHAGLTEERVADSRTGVFIGL TH_4621|M.thermoresistible__bu PEFFGISEREAISIDPQQRLLLETSWEAMEHAGLTPADVEGSSTGVFVGL MSMEG_4727|M.smegmatis_MC2_155 PEFFGITEREAAAIDPQHRLLLETAWEAVEHSGLNPAGLAGSATGVFMGL MAB_3148c|M.abscessus_ATCC_199 ADFFSINEREAVSIDPQHRVLLETSWQAVEHAGIDPRALAGSQTGVFVGV Mflv_0405|M.gilvum_PYR-GCK PEFFGLSPREAVWIEPQQRLMLETVWEGLERAGYAPSALRGSRTGVFVGV Mvan_0269|M.vanbaalenii_PYR-1 PEFFGISPREAVWIEPQQRLMLETVWEGLERAGLAPADLRGSRTGIFVGV .:**.:. *** ::**:* :*** *:.:*:.* : .* *.:* *: Mb2965c|M.bovis_AF2122/97 THEDYLVLT-TTAGGLASPYVVTGLNNSVASGRIAHTLGLHGPAMTFDTA Rv2940c|M.tuberculosis_H37Rv THEDYLVLT-TTAGGLASPYVVTGLNNSVASGRIAHTLGLHGPAMTFDTA MLBr_00139|M.leprae_Br4923 THEDYLVLT-TAAGGLASPYVVTGLNNSVASGRISHTLGLHGPAMTFDTA MMAR_1767|M.marinum_M SHEDYLVRS-VLAGDLAGPYASTGLINSVASGRIAHTLGLHGPAMTVDTA MUL_2010|M.ulcerans_Agy99 SHEDYLVRS-VLAGDLAGPYASTGLINSVASGRIAHTLGLHGPAMTVDTA MAV_2370|M.avium_104 THGDYQLLA-ADTRSVEGAYGFSGSNFSLASGRIAYALGVHGPALTVDTA TH_4621|M.thermoresistible__bu SHDDYALLT-SDAGALEEAYGFTGSAFSMASGRIAYRLGVHGPAVTVDTA MSMEG_4727|M.smegmatis_MC2_155 THNDYAHLA-ADAKALEGPYGFTGTSFSLASGRIAYALGVHGPAITVDTA MAB_3148c|M.abscessus_ATCC_199 THNDYQLVA-ADAADLGGPYGFAGTNFCMASGRISYALGVHGPSLTVDAG Mflv_0405|M.gilvum_PYR-GCK AANEYAHLLSAESIDKIEPHFITGNALNAISGRVAFALGLEGPAVAVDTA Mvan_0269|M.vanbaalenii_PYR-1 AANEYAHLLSSESIEKIEPHFITGNALNAISGRVAFALGLEGPAVAVDTA : :* : .: :* ***::. **:.**:::.*:. Mb2965c|M.bovis_AF2122/97 CSSGLMAVHLACRSLHDGEADLALAGGCAVLLEPHACVAASAQGMLSSTG Rv2940c|M.tuberculosis_H37Rv CSSGLMAVHLACRSLHDGEADLALAGGCAVLLEPHASVAASAQGMLSSTG MLBr_00139|M.leprae_Br4923 CSSGLMAVHLACRSLHDGESDLALAGGCAVLLEPHASVAASAQGMLSSTG MMAR_1767|M.marinum_M CSSGLLTVHLACRSLHEGESDLALAGGCALLLEPNGSVSLSSQGMLSPTG MUL_2010|M.ulcerans_Agy99 CSSGLLTVHLACRSLHEGESDLALAGGCALLLEPNGSVSLSSQGMLSPTG MAV_2370|M.avium_104 CSSGLTAIHLACRSLHEGESDLALAGGATLALDPRKFSAGSAEGMLSPTG TH_4621|M.thermoresistible__bu CSSSLLAVHMACRSLQVGESDLALAGGAMVMLEPRKYTSASGLGMLSPTG MSMEG_4727|M.smegmatis_MC2_155 CSSSLSAIHMACRSLHDGESDVALAGGVSVLLEPRKAAGGSAAGMLSPTG MAB_3148c|M.abscessus_ATCC_199 CAAGLATVHMGCQSLAAGESDLVLAGGVNLVLEPRRYVGASQQRMLSPTG Mflv_0405|M.gilvum_PYR-GCK CSSSLVAVHQATQALRSGDCDMALAGGVNVLLSPVTVVAASRARMLSPVG Mvan_0269|M.vanbaalenii_PYR-1 CSSALVAVHQACQALHSGDCDLALAGGVNVLLSPVTSVAASRARMLSPVG *::.* ::* . ::* *:.*:.**** : *.* . * ***..* Mb2965c|M.bovis_AF2122/97 RCHSFDADADGFVRSEGCAMVLLKRLPDALRDGNRIFAVVRGTATNQDGR Rv2940c|M.tuberculosis_H37Rv RCHSFDADADGFVRSEGCAMVLLKRLPDALRDGNRIFAVVRGTATNQDGR MLBr_00139|M.leprae_Br4923 RCKSFAADADGFVRSEGCAMVLLKRLPDALRDGNRIFAMILGTATNQDGG MMAR_1767|M.marinum_M RCHAFDVDADGFVRSEGCAVVVLKRLSDALADGDRILAVVRGTAANQDGR MUL_2010|M.ulcerans_Agy99 RCHAFDVDADGFVRSEGCAVVVLKRLSDALADGDRILAVVRGTAANQDGR MAV_2370|M.avium_104 RCHAFDVAADGFVGGEGSVMLLLKRLNDALRDGDRILAVVRGTAANQDGH TH_4621|M.thermoresistible__bu RCHAFDVAADGFVRSEGSVMLLLKRLPDALRDNDRILAVVRGTAANQDGR MSMEG_4727|M.smegmatis_MC2_155 HCHAFDTAADGFVSAEGCVVLTLKRLDDAVADGDRILAVIRGTATNQDGR MAB_3148c|M.abscessus_ATCC_199 RCHTFTGEADGFVMSEGCVMVLLKRLDDAVRDGDRILAVVRGTASNQDGR Mflv_0405|M.gilvum_PYR-GCK RCKTFDASADGYVRSEGCGILVLKRLSDAVRDGDRVCAVIAGSAVNQDGA Mvan_0269|M.vanbaalenii_PYR-1 RCKTFDASADGYVRSEGCGILVLKRLGDAVRDGDRVCAVIPSSAVNQDGA :*::* ***:* .**. :: **** **: *.:*: *:: .:* **** Mb2965c|M.bovis_AF2122/97 TETLTMPSEDAQVAVYRAALAAAGVQPETVGVVEAHGTGTPIGDPIEYRS Rv2940c|M.tuberculosis_H37Rv TETLTMPSEDAQVAVYRAALAAAGVQPETVGVVEAHGTGTPIGDPIEYRS MLBr_00139|M.leprae_Br4923 TETLMMPSEDAQVAVYQAALAVAGVEPETIGVVEAHGTGTPIGDPIEYRS MMAR_1767|M.marinum_M SETLLMPSETAQVAVYREALAAAGVDPASVGAVEVHGTGTPVGDPIEYRS MUL_2010|M.ulcerans_Agy99 SETLLMPSETAQVAVYREALAAAGVDAASVGAVEVHGTGTPVGDPIEYRS MAV_2370|M.avium_104 TVNIATPSKTAQTAVYRAALAAAGVDAGTVGMVEAHGPGTPVGDPIEYAS TH_4621|M.thermoresistible__bu TENISTPSIQAQADVYRSALAVAGVDPATVGMVEAHGTGTPVGDPIEYNS MSMEG_4727|M.smegmatis_MC2_155 TVNIATPSADAQAKVYRMALKAAGVEPGTVGLVEAHGTGTPVGDPLEFSS MAB_3148c|M.abscessus_ATCC_199 TVNQSTPSSEAQAAACRTALAVAGVEADTVGLIEAHGTGTPVGDPIEYTG Mflv_0405|M.gilvum_PYR-GCK SSGLTVPNGGAQQRLIGTVLARAGITGGEVDYLEAHGTGTPLGDPIEVQA Mvan_0269|M.vanbaalenii_PYR-1 SSGLTVPNGGAQQRLIGMALARAGLSGGDVDYLEAHGTGTPLGDPIEVQA : *. ** .* **: :. :*.**.***:***:* . Mb2965c|M.bovis_AF2122/97 LARVYGAG----TPCALGSAKSNMGHSTASAGTVGLIKAILSLRHGVVPP Rv2940c|M.tuberculosis_H37Rv LARVYGAG----TPCALGSAKSNMGHSTASAGTVGLIKAILSLRHGVVPP MLBr_00139|M.leprae_Br4923 LARVYGAG----TPCALGSAKSNMGHSTASAGTVGLIKAILSLRNGLVPP MMAR_1767|M.marinum_M LAQVYGSGG---SRCMLGSVKTNIGHSESAAGTVGLIKATLSLGHGVVPP MUL_2010|M.ulcerans_Agy99 LAQVYGSGG---SRCMLGSVKTNIGHSESAAGTVGLIKATLSLGHGVVPP MAV_2370|M.avium_104 LAEVYGID----GPCALASVKTNFGHAQAASGALGMMKAILALQHGVVPR TH_4621|M.thermoresistible__bu LTQVYGKT----GPCALTSVKTNFGHAESAAGALGMMKAILALQHGVVPQ MSMEG_4727|M.smegmatis_MC2_155 LAEVYGTD----GPCALGSIKTNFGHTQSAAGALGVMKAVLALQHNVIPQ MAB_3148c|M.abscessus_ATCC_199 LAQVYGVD----GPCAVGSVKTNFGHTMSAAGALGLMKIVLAVEHGVVPP Mflv_0405|M.gilvum_PYR-GCK AAAAYAGARDADRPLLMGSVKTNIGHTESASGAAGLIKVVLSLQHETLPQ Mvan_0269|M.vanbaalenii_PYR-1 AAAAYGASRDADRPLLMGSVKTNIGHLESASGAAGLIKVVLSLQHNLLPQ : .*. : * *:*:** :::*: *::* *:: : :* Mb2965c|M.bovis_AF2122/97 LLHFNRLPDELSDVETGLFVPQAVTPWPNGNDHTPKRVAVSSFGMSGTNV Rv2940c|M.tuberculosis_H37Rv LLHFNRLPDELSDVETGLFVPQAVTPWPNGNDHTPKRVAVSSFGMSGTNV MLBr_00139|M.leprae_Br4923 LLHFDRLSDDLTEIETGLFVPQEVTPWPVGGYNTPKRVAVSSFGMSGTNV MMAR_1767|M.marinum_M MVHHTRLPDELAEIETGLYVPHEITPWP--EDQGPRRIAVSSFGMSGTNV MUL_2010|M.ulcerans_Agy99 MVHHTRLPDELAEIETGLYVPHEITPWP--EDQGPRRIAVSSFGMSGTNV MAV_2370|M.avium_104 NLHFTQLPDDLARIDTKLFVPQQTTPWVS-NGGHPRRAAVSSYGLSGTNV TH_4621|M.thermoresistible__bu NLHFTRLPDEMAAIETNLFVPQATTLWPV-REGCPRRAAVSSYGMSGTNV MSMEG_4727|M.smegmatis_MC2_155 NLHFTRLPDQMAEIETGLFVPETITPWPV-REGQPRRAAVSAYGLSGTNV MAB_3148c|M.abscessus_ATCC_199 NLHFTGIPDKLAPVKTNLFVPQTVIPWPG-KAQGPRRAGVSAYGMSGSNV Mflv_0405|M.gilvum_PYR-GCK SLHFDTPSPHIPWDSLPVRVVDTAMPWQP--NGRPRRAGVSSFGFTGTNA Mvan_0269|M.vanbaalenii_PYR-1 SLHFENPSPHIPWDSLPVRVVDKAIPWQA--DGRPRRAGVSSFGFTGTNA :*. . .:. . : * . * *:* .**::*::*:*. Mb2965c|M.bovis_AF2122/97 HAIVEEAPAEASAP---ESSP--GDAEVGPRLFMLSSTSSDALRQTARQL Rv2940c|M.tuberculosis_H37Rv HAIVEEAPAEASAP---ESSP--GDAEVGPRLFMLSSTSSDALRQTARQL MLBr_00139|M.leprae_Br4923 HVIVEEAPSEACAPDVPETSPGTGDATVGRQLFMLSSTSIAALRETARQL MMAR_1767|M.marinum_M HAILEEPPTPAPARDQAPAEP----GMASPLLFALSSTSADGLRQTAREL MUL_2010|M.ulcerans_Agy99 HAILEEPPTPAPARDQASAEP----GMASPLLFALSSTSADGLRQTAREL MAV_2370|M.avium_104 HAILEQAP-EPAPETVAPEGI----SAESPLLFPLSSTSADELRRTAGRL TH_4621|M.thermoresistible__bu HAVLEQAP-EPVQRPEESADT----DAAGPLVFALSSTSAEELRRTAGRL MSMEG_4727|M.smegmatis_MC2_155 HAVLEQAPESPAETAAEAISP----KAGNALVFPVSASSADALRSTAQHL MAB_3148c|M.abscessus_ATCC_199 HAVVEQAP-PVESSTPPAVES----PLGSQLIFPVSSTSAEELRRTAARL Mflv_0405|M.gilvum_PYR-GCK HVLIEEAPTDLAGPTEPTAPAEPVDEDAAADPAPAPVEVLPLSARSPEAL Mvan_0269|M.vanbaalenii_PYR-1 HVLIEEAPLPQA--------ADPVEE---PDTRALPVGVLALSARSPEAL *.::*:.* . :. * Mb2965c|M.bovis_AF2122/97 ATWV---EEHQD---CVAASDLAYTLARGRAHRPVRTAVVAANLPELVEG Rv2940c|M.tuberculosis_H37Rv ATWV---EEHQD---CVAASDLAYTLARGRAHRPVRTAVVAANLPELVEG MLBr_00139|M.leprae_Br4923 ATWV---EEHQD---SVVLSDLAYTLARGRAHRPVRTAVVAADLPELVEG MMAR_1767|M.marinum_M AEWVGSRADSAD---STEAVDLAYTLARRRAHRPVRTAVVAASLPELVEG MUL_2010|M.ulcerans_Agy99 AEWVGSRADSAD---STEAVDLAYTLARRRAHRPVRTAVVAASLPELVEG MAV_2370|M.avium_104 ADWVHAHGD------LALP-DLAYTLARRRVHRPVRTAVLAGDRAQLIEA TH_4621|M.thermoresistible__bu AEWVEAHTD------EVVPADLAYTLARRRAHRPVRTTVIADGVEALTAG MSMEG_4727|M.smegmatis_MC2_155 ADWLLRSGDGNGRGPAIDLGDLAYTLARRRGFRAARSAVLAGDRGTLVEG MAB_3148c|M.abscessus_ATCC_199 ADWVAERPE-------VAPGDVGYTLARRRAHRSVRTAVVADGADELIDA Mflv_0405|M.gilvum_PYR-GCK VALAQRYETWLTAHPEADLADVCRTAGTGRSHFEHRAALVVDSVESARIA Mvan_0269|M.vanbaalenii_PYR-1 TALAQRYEAWLSAHPDADLADVCRTAGTGRSHFEHRAALVVDSVAAAREG . *: * . * . *::::. . . Mb2965c|M.bovis_AF2122/97 LREVADGDALYDAAVGHGDRGP--VWVFSGQGSQWAAMGTQLLASEPVFA Rv2940c|M.tuberculosis_H37Rv LREVADGDALYDAAVGHGDRGP--VWVFSGQGSQWAAMGTQLLASEPVFA MLBr_00139|M.leprae_Br4923 LCEIADGDALYDAVVGHGDRGP--VWVFSGQGSQWASMGVQLLANEPVFA MMAR_1767|M.marinum_M LQEVAEGDLMYEAAVGRGDRGP--VWVFSGQGSQWAAMGADLLANEPVFA MUL_2010|M.ulcerans_Agy99 LQEVAEGDLVYEAAVGRGDRGP--VWVFSGQGSQWAAMGADLLANEPVFA MAV_2370|M.avium_104 LREVADGDTPYPAAVGRGDRGP--VWVFSGQGSQWAAMGADLLATEPVFA TH_4621|M.thermoresistible__bu LREVADGDAPYQPAVGMDDKAP--VWVFSGQGSQWAGMGAELLATEQVFA MSMEG_4727|M.smegmatis_MC2_155 LRQIADGEAMPQQAVTNDDRGP--VWVFSGQGSQWASMGAELLDREPAFA MAB_3148c|M.abscessus_ATCC_199 LRGVAEGDAPYPAAVAQDDRGP--VWLFSGQGSQWAGMGAELLGKEPVFA Mflv_0405|M.gilvum_PYR-GCK LTDLAQNRLRPGVVRGEHLNHPTTAWMFTGQGSQYPGMARELFDTEPVFA Mvan_0269|M.vanbaalenii_PYR-1 LAELAQNRLRPGVVRGEHTHHPTTAWLFTGQGSQFPGMARELFETEPVFA * :*:. . . * .*:*:*****:..*. :*: * .** Mb2965c|M.bovis_AF2122/97 ATIAKLEPVIAAESGFSVTEAITAQQTVTG---------IDKVQPAVFAV Rv2940c|M.tuberculosis_H37Rv ATIAKLEPVIAAESGFSVTEAITAQQTVTG---------IDKVQPAVFAV MLBr_00139|M.leprae_Br4923 ATITKLEPVIAAESSFSVTEAITAPETVTG---------IDKVQPSVFAV MMAR_1767|M.marinum_M ATVAAVEPIIAHESGFSVTEAMTAPEKVTG---------IDKVQPTLFAM MUL_2010|M.ulcerans_Agy99 ATVAAVEPIIAHESGFSVTEAMTAPEKVTG---------IDKVQPTLFAM MAV_2370|M.avium_104 ATVAQAEPLIARESGFSVAEAMSAPQTVTG---------QDRVQPTLFTM TH_4621|M.thermoresistible__bu AKIAEIEPLVARESGFSVTEAMTASETVTG---------IDRVQPTLFAI MSMEG_4727|M.smegmatis_MC2_155 AAIAELEPLIAAESDFSVTEALTASETVTG---------IDRVQPTIFAV MAB_3148c|M.abscessus_ATCC_199 ETIARLEPLIHAESGFSVTDAISAPETVTG---------IDRVQPTLFAM Mflv_0405|M.gilvum_PYR-GCK DTVTRCADAVADLLPRPLLDVMFAGGREAGVPPTETLRHTSFAQPALFAV Mvan_0269|M.vanbaalenii_PYR-1 DAVTRCADAVKDILPRPLLEVLFAADRESG----EALRHTSFAQPAIFAV :: : .: :.: * :* . .**::*:: Mb2965c|M.bovis_AF2122/97 QVALAATMEQTYGVRPGAVVGHSMGESAAAVVAGALSLEDAARVICRRSK Rv2940c|M.tuberculosis_H37Rv QVALAATMEQTYGVRPGAVVGHSMGESAAAVVAGALSLEDAARVICRRSK MLBr_00139|M.leprae_Br4923 QVALATTMEQTYGVRPGAVIGHSMGESAAAVVAGALSLEDAARVICRRSK MMAR_1767|M.marinum_M QVALAATMEKTYGVRPGAVIGHSLGEAAAAVVAGSLSLEDGARVISRRSK MUL_2010|M.ulcerans_Agy99 QVALAATMEKTYGVRPGAVIGHSLGEAAAAVVAGSLSLEDGARVISRRSK MAV_2370|M.avium_104 QVALAATMKA-HGVRPGAVIGHSLGEAAAAVVAGALSLEDGARVICRRSR TH_4621|M.thermoresistible__bu QVALAATMQS-YGVRPGAVIGHSLGEVAAAVVAGALSLEDGVKVICRRSR MSMEG_4727|M.smegmatis_MC2_155 QVALAAAMRS-HGVVPGAVIGHSMGEVAASVVSGALSLEDGVKVICRRTR MAB_3148c|M.abscessus_ATCC_199 QVSLAATLAS-YGVRPGAVIGHSMGEVAAAVVSEALSLEDGVKVICRRSQ Mflv_0405|M.gilvum_PYR-GCK EMGLARLWQS-WGIVPDVVLGHSVGQYAAACVAGVFSLEDGARLMAERGR Mvan_0269|M.vanbaalenii_PYR-1 EMGLARLWQS-WGIEPDVVLGHSVGQYAAACVAGVFSLEDGARLMAERGR ::.** *: *..*:***:*: **: *: :****..:::..* : Mb2965c|M.bovis_AF2122/97 LMTRIAGAGAMGSVELPAKQVNSELMARGIDDVVVSVVASPQSTVIGGTS Rv2940c|M.tuberculosis_H37Rv LMTRIAGAGAMGSVELPAKQVNSELMARGIDDVVVSVVASPQSTVIGGTS MLBr_00139|M.leprae_Br4923 LMNRVAGSGAMGSVELPAKQVNSELMARGIDDVVISVVASPQSTVIGGAT MMAR_1767|M.marinum_M LMLRISGAGAMASVELPAKQVNSELMARGIDDVAVAVVASPQSTVVGGAT MUL_2010|M.ulcerans_Agy99 LMLRISGAGAMASVELPAKQVNSELMARGIDDVAVAVVASPQSTVVGGAT MAV_2370|M.avium_104 LMSRVAGTGATASVELPAQQVLSELTARGISDVVVAVVASPQSTVIAGAA TH_4621|M.thermoresistible__bu LCLRLAGAGAMAAIELPAQAVREFLAARGVDDVVLSVIASPESTVIGGAT MSMEG_4727|M.smegmatis_MC2_155 LMTRIAGSGAMAMVELPAQQVLSELASRGVDDVVLSVVASPQSTVVGGAT MAB_3148c|M.abscessus_ATCC_199 LMLRISGAGAMASVDLPAQQVVSELADRDIHDVVLAVVASPQSTVVGGAT Mflv_0405|M.gilvum_PYR-GCK LFGSLPEGGRMVAVFADAKRVEQVAAD--FPRVSVGAYNGP-NTVLSGPG Mvan_0269|M.vanbaalenii_PYR-1 MFGSLPEGGRMVAVFTDAKLVEEIAGD--FPRVSVGAYNGP-NTVLSGPG : :. * : *: * . . * :.. .* .**:.*. Mb2965c|M.bovis_AF2122/97 DTVRDLIARWEQRDVMAREVAVDVASHSPQVDPILDDLAAALADIAPMTP Rv2940c|M.tuberculosis_H37Rv DTVRDLIARWEQRDVMAREVAVDVASHSPQVDPILDDLAAALADIAPMTP MLBr_00139|M.leprae_Br4923 ETVRDLIAQWEQRDVMAREVAVDVASHSSQVDPILDDLAAALADIAPMTP MMAR_1767|M.marinum_M DTVRDLVARWEQREVMAREVAVDVASHSPQVDPILEDLATALADIVPSDP MUL_2010|M.ulcerans_Agy99 DTVRDLVARWEQREVMAREVAVDVASHSPQVDPILEDLATALADIVPSDP MAV_2370|M.avium_104 PTVRDLVTAWQERGVMAREVPTDVAFHSPQVDPIMDDLTDALAEISPRPP TH_4621|M.thermoresistible__bu DTVRELVAAWEAQGVMAREVAVDVASHSPQVDPILDELEEILADLQPMTP MSMEG_4727|M.smegmatis_MC2_155 ASVRELIEMWESRGVMAREIAVDVASHSPQVDPILDDLIEALADLDPAEP MAB_3148c|M.abscessus_ATCC_199 ETVRQLIAEWSDRGLMAREVAVDVASHSPQVDPILDDLADALEDLTPRTP Mflv_0405|M.gilvum_PYR-GCK EDLEQIVGTFGEDGIRCTWLETSHAFHSELLDPVLDEFESYAAQLQFAAP Mvan_0269|M.vanbaalenii_PYR-1 EDLEQIVDRFGDDGVRCTWLQTSHAFHSELLDPVLDEFESYAAQFQFATP :.::: : : . : .. * ** :**::::: :: * Mb2965c|M.bovis_AF2122/97 KVPYYS-ATLFDPREQPVCDGAYWVDNLRNTVQFAAAVQAAMEDGYRVFA Rv2940c|M.tuberculosis_H37Rv KVPYYS-ATLFDPREQPVCDGAYWVDNLRNTVQFAAAVQAAMEDGYRVFA MLBr_00139|M.leprae_Br4923 KVPYYS-ATLFDPRELPVCNGAYWVDNLRNTVQFAAAVQAAMEDGYRVFA MMAR_1767|M.marinum_M KVPYYS-ATLFDPRERPTCDAAYWVDNLRNTVQFAAAVQAALEDGFRVFA MUL_2010|M.ulcerans_Agy99 KVPYYS-ATLFDPRERPTCDAAYWVDNLRNTVQFAAAVQAALEDGFRVFA MAV_2370|M.avium_104 EVPYYS-ATLFDPREQPVCDARYWANNMRRMVRFATAVQAALEDGYRVFA TH_4621|M.thermoresistible__bu TVPYYS-ATSYDPREKPVCDADYWVDNLRHEVRFAAAVQAALEDGFRVFG MSMEG_4727|M.smegmatis_MC2_155 EIPYYS-ATLYDPRDYADYDAYYWADNLRHTVRFSAAVQAALEDGHRVFA MAB_3148c|M.abscessus_ATCC_199 VVPLYS-SVSFDPRERPIMDADYWVDNLRHTVRFAAAVQAALDDGYRVFG Mflv_0405|M.gilvum_PYR-GCK TLPLVCNRTGAVLTGQTSLDAQYWRRHSRQPVQFAESVRTVAALGCSVLM Mvan_0269|M.vanbaalenii_PYR-1 TLPLVCNRTGTVLTAQTPLDAQYWRRHSRQPVQFAESVRTVAALGCSVLM :* . . . :. ** : *. *:*: :*::. * *: Mb2965c|M.bovis_AF2122/97 ELSPHPLLTHAVEQTGRSLDMSVAALAGMRREQPLPHGLRGLLTELHRAG Rv2940c|M.tuberculosis_H37Rv ELSPHPLLTHAVEQTGRSLDMSVAALAGMRREQPLPHGLRGLLTELHRAG MLBr_00139|M.leprae_Br4923 ELSPHPLLTHAVEQTARNLDMSVAALAGMRREQSMPYGLRGLLADLHSAG MMAR_1767|M.marinum_M ELSPHPLLTHAVDQNARSLDMSAAALAGMRREQPLPHGLRGLLTDVHSAG MUL_2010|M.ulcerans_Agy99 ELSPHPLLTHAVDQNARSLDMSAAVLAGMRREQPLPHGLRGLLTDVHSAG MAV_2370|M.avium_104 ELAPHPLLVRALEQTARSREIPMAALAGMRRGQALPHGLRGFVADLHNAG TH_4621|M.thermoresistible__bu ELSPHPLLTRAVEQTARGLDMPVAALPAMRREQEMPHGVRTMVGDLFAAG MSMEG_4727|M.smegmatis_MC2_155 ELSPHPLLTHPVEQTARSLDMPLAVFAAMRRQQEMPHGLLGFVADLHSAG MAB_3148c|M.abscessus_ATCC_199 ELAPHPLLVYPAEQTARSLDIPMVALAGMRREQELPHGLRDFVGDLYTAG Mflv_0405|M.gilvum_PYR-GCK EIGPQPVLTGAAVQVWPEHLAAPRAIASLRKGVADRRQIADALAAAYIGG Mvan_0269|M.vanbaalenii_PYR-1 EIGPQPVLTGSAVQVWPEHLAAPRAIVSLRKGVSDRRQITEALAAAYVGG *:.*:*:*. . * . .: .:*: : : . .* Mb2965c|M.bovis_AF2122/97 AALDYSALYP-AGRLVDAPLPAWTHARLFIDDDGQEQRAQGACTITVHPL Rv2940c|M.tuberculosis_H37Rv AALDYSALYP-AGRLVDAPLPAWTHARLFIDDDGQEQRAQGACTITVHPL MLBr_00139|M.leprae_Br4923 AALDFAALYP-AGRLLDAPLPVWTHPRLFIDTDGQEQRAQGACTVTVHPL MMAR_1767|M.marinum_M AAVDFSVLYP-AGRLVNAPLPAWTHRRFFVDGEGQDSKAQGACSVTVHPL MUL_2010|M.ulcerans_Agy99 AAVDFSVLYP-AGRLVNAPPPAWTHRRFFVDGEGQDSKAQGACSVTVHPL MAV_2370|M.avium_104 AAVDFSVLYP-TGRLVDAPLPTWTHRRLWLTDGGLESPTHGGCTVAVHPL TH_4621|M.thermoresistible__bu AAVDFAALYP-SGRLVDAPLPTWTRRKLVLSRENGEQQTRGGCTITVHPL MSMEG_4727|M.smegmatis_MC2_155 AAVDFSVLYP-TGRLLDAPLPAWTHSTLLLDR-ELESSAPGVPSVSVHPL MAB_3148c|M.abscessus_ATCC_199 GAVDFSVLYP-TGQLVDVPLPSWTRRSYLLDLSAQAQQGHGTHTVAVHPL Mflv_0405|M.gilvum_PYR-GCK HKPDFAALHEQRGVRLELPTYPFQRRRFWPKSAGMAIDGR-VGASAGSGI Mvan_0269|M.vanbaalenii_PYR-1 HRPDFGALYRRPGRAVALPTYPFQRRRFWPKTSGITTDG-----PAVSGI *:..*: * : * : : : : Mb2965c|M.bovis_AF2122/97 LGSHVRLTEEPERHVWQGDVGTSVLSWLSDHQVHNVAALPGAAYCEMALA Rv2940c|M.tuberculosis_H37Rv LGSHVRLTEEPERHVWQGDVGTSVLSWLSDHQVHNVAALPGAAYCEMALA MLBr_00139|M.leprae_Br4923 LGSHVRLLEEPERHIWQGDVGTAALSWLADHQVHNVAALPGAAYCEMALA MMAR_1767|M.marinum_M LGAHVRLSEQPERHVWQTDVGTDTLSWLSDHQVRNVAALPGAAYCEMALA MUL_2010|M.ulcerans_Agy99 LGAHVRLSEQPERHVWQTDVGTDTLSWLSDHQVRNVAALPGAAYCEMALA MAV_2370|M.avium_104 LGPHVHLQEEPERHLWQADVGTAAQPWLADHQIRNVVVLPGAAYCEMALA TH_4621|M.thermoresistible__bu LGTHVRLPEEPERHVWQADLGTGAQPWLADHQIHTVAALPGAAYCEMALA MSMEG_4727|M.smegmatis_MC2_155 LGSHVVLPQEPEEHLWQGDVGTEAHPWLSDHRVHQVAVLPGAAYCEMALA MAB_3148c|M.abscessus_ATCC_199 LGAHVRLAEEPERHIWQADVGTVGQPWIADHQVRHVAVYPGAAYCEMALS Mflv_0405|M.gilvum_PYR-GCK LGSGKDLASG--DSVYTSRLSVKTQPWLSDHVIYGTVVVPGATYAAMALA Mvan_0269|M.vanbaalenii_PYR-1 LGSAKDLASG--DTVYTSRWSVRSQPWLADHVIYGTVVVPGATYAAMALA **. * . :: .. .*::** : ... ***:*. ***: Mb2965c|M.bovis_AF2122/97 AAAEVFGEA-AEVRDITFEQMLLLDEQTPIDAVASIDAP--GVVNFTVET Rv2940c|M.tuberculosis_H37Rv AAAEVFGEA-AEVRDITFEQMLLLDEQTPIDAVASIDAP--GVVNFTVET MLBr_00139|M.leprae_Br4923 AAVEVFGEA-AEVRAIAFEQMLLLAAETPIDAIASVDAP--GVINFVVQA MMAR_1767|M.marinum_M AAGEVFGEA-FEVRDLAFEQMLLLDEETPIDAVASLDSP--GAANFVVQT MUL_2010|M.ulcerans_Agy99 AAGEVFGEA-FEVRDLAFEQMLLLDEETPIDAVASLDSP--GAANFVVQT MAV_2370|M.avium_104 AARSVLGAT-AEVRDIRFEQALLLDEQTTVDASASVSSP--GVLHFTVQS TH_4621|M.thermoresistible__bu AAREVIDSDGVEVRDVRFEQMLLLDEQTEVSAVASAVEP--GTLEFAVET MSMEG_4727|M.smegmatis_MC2_155 AVTPVLGDT-GEVHDLKFHDMLLLDDATPVWVSAAVTAP--GTAEFGVET MAB_3148c|M.abscessus_ATCC_199 AAAAVFGEG-SAVQSISFEQLLTLGESTPISATATAKSA--DILEFVVET Mflv_0405|M.gilvum_PYR-GCK AVGTPAHAK-----DVFFYEPIILPEKSSREVQLTVHPSVDGESKFQVHS Mvan_0269|M.vanbaalenii_PYR-1 AVGTPARVK-----DVFFYEPIILPEKASREVQLTLHPSEDGGQKFQVHS *. : * : : * : . : . . .* *.: Mb2965c|M.bovis_AF2122/97 NRDGET----TRHATAALRAAEDDCPPPGYDITALLQAHPHAVN---GTA Rv2940c|M.tuberculosis_H37Rv NRDGET----TRHATAALRAAEDDCPPPGYDITALLQAHPHAVN---GTA MLBr_00139|M.leprae_Br4923 NQDGEK----MRNATATLHAAEDDCPPPAYDIAALLEAHPNSVN---GTD MMAR_1767|M.marinum_M HVDGET----TRHATAALRASDDESVPPAYDIAALLAAHPVSVN---GAE MUL_2010|M.ulcerans_Agy99 HVDGET----TRHATAALRASDDESVPPAYDIAALLAAHPVSVN---GAE MAV_2370|M.avium_104 HQGGEQ----ARHASAVLGAATD-EQPAAHDLSALLTAHPHDDD---GDE TH_4621|M.thermoresistible__bu AKDGEH----ERRATAVLGAADDTEPPQAHDIDALLAEHPTRIE---GDE MSMEG_4727|M.smegmatis_MC2_155 HQSGDR----TQRATAVLRGDVDAERPAAHSIDALLAAHPNRVD---GDE MAB_3148c|M.abscessus_ATCC_199 HDEGDV----VKRATAVLGNGGDVDMPIAYDLSALRAEHPHRES---GDD Mflv_0405|M.gilvum_PYR-GCK RPYGERGAEWALNAEGVVASGVGDSPAAAGDLEDPVDEAIERLNRMRPQE Mvan_0269|M.vanbaalenii_PYR-1 REYGERGTEWSLNAEGTVASGVDENPQAE--PSGPVDEAIERLNRMRPQD *: .* ..: . . Mb2965c|M.bovis_AF2122/97 MRESFAERGVTLGAAFGGLTTAHTAEAGAATVLAEVALPASIRFQQGAYR Rv2940c|M.tuberculosis_H37Rv MRESFAERGVTLGAAFGGLTTAHTAEAGAATVLAEVALPASIRFQQGAYR MLBr_00139|M.leprae_Br4923 LRESFAERGVQLGAAFAGLATAHTAEAESGTVLAEVALPASIRFQQSSYQ MMAR_1767|M.marinum_M LREAFVERGIQHGPAFSGLAIARTAETEGGTVLAEVALPASIRFQQGAYG MUL_2010|M.ulcerans_Agy99 LREAFVERGIQHGPAFSGLAIARTAETEGGTVLAEVALPASIRFQQGAYG MAV_2370|M.avium_104 VRRRMDRRGVQYGPAFAGLGAVHSGDETGT-VLAEVALPRQIRSQQAAYG TH_4621|M.thermoresistible__bu LRQWFDQRGVQFGPAFTGLTAARIPEGTVTSVLAEVGLPGQIRSQQAPYG MSMEG_4727|M.smegmatis_MC2_155 LRAGFGTVGIGHGAAFAGLSEAYVATAAEPTVVAAVALPGPLRSGQRGYT MAB_3148c|M.abscessus_ATCC_199 LRASFDERGVQYGPAFQGLAAAYRGDETVRSVLAEVTLPRDVRAQQGSYI Mflv_0405|M.gilvum_PYR-GCK LFETFADLELAWGPTWSGSLKSLWLG--EGEAIGDILVGAELAEQLGTEP Mvan_0269|M.vanbaalenii_PYR-1 LFETFADMELAWGPTWSGSLKSLWLG--EGEAIGDILVGEELAEQLGTEP : : : *.:: * .:. : : : Mb2965c|M.bovis_AF2122/97 IHPALLDACFQSVGAGVQAGTATG----GLLLPLGVRSLRAYGPTRNARY Rv2940c|M.tuberculosis_H37Rv IHPALLDACFQSVGAGVQAGTATG----GLLLPLGVRSLRAYGPTRNARY MLBr_00139|M.leprae_Br4923 IHPALLDACFQSVGAGVDATKVGSR--AGLLLPLGVRSLRVYRPTRNARY MMAR_1767|M.marinum_M VHPALLDACFQSVAAGVKSTGGGG-----LLLPLGVRSLRAYGPTRNAQY MUL_2010|M.ulcerans_Agy99 VHPALLDACFQSVAAGVKSTGGGG-----LLLPLGVRSLRAYGPTRNAQY MAV_2370|M.avium_104 AHPALLDACFQSVEAHPAVRALGD---GALGLVLGIRRLRAYGAARNAHY TH_4621|M.thermoresistible__bu IHPALLDACFQSVAAHPDVQGAGS---GLL-LPLGVRRLQAFGPTRGARY MSMEG_4727|M.smegmatis_MC2_155 VHPALLDACFQSVIAHPEVQNIAS---GML-LPLGVRRLRAYGSTRNVRY MAB_3148c|M.abscessus_ATCC_199 VHPALLDACFQSVIALPDVQEASK---DALPLPKGVRSLHAYESARATQY Mflv_0405|M.gilvum_PYR-GCK MHPVLMDLCTGVAFPAFPALLAAEQGVNDLYLPLRYGQVSLQEKMPRRFY Mvan_0269|M.vanbaalenii_PYR-1 MHPVLMDLCTGVAFPAFPALLAAEQGVSDLFLPLRYGQVTLRDKMPRRFY **.*:* * . . * * : * Mb2965c|M.bovis_AF2122/97 CYTRLTKAFNDGTRGGEADLDVLDEHGTVLLAVRGLRMGTGTSERDERDR Rv2940c|M.tuberculosis_H37Rv CYTRLTKAFNDGTRGGEADLDVLDEHGTVLLAVRGLRMGTGTSERDERDR MLBr_00139|M.leprae_Br4923 CYTRLTKIE---PRGGEADLDVLDEHGAVLLAVRGLHMGTGTTERGELDR MMAR_1767|M.marinum_M CYTRVTKAD---ANGGEADLELLDEQGCVLLAVRGLRLGTGTSESGERDR MUL_2010|M.ulcerans_Agy99 CYTRVTKAD---ANGGEADLELLDEQGCVLLAVRGLRLGTGTSESGERDR MAV_2370|M.avium_104 CYTRVTKAD---TSGVEADIDVLDEHGAVLLAVQGLRVGTSASESGTRDR TH_4621|M.thermoresistible__bu CYARVTDAD---GSKAEADLDVLDEHGNVLLRVQGLLMGGAAADGDDRDR MSMEG_4727|M.smegmatis_MC2_155 CLSRIVKAD---SFGVEADLELLDADGTVLLSAMGLQLGTGNSDKAEEER MAB_3148c|M.abscessus_ATCC_199 CYTRVTKVV---GNEVEADIDLLDETGSVLIAVRGFRFGTGSSDDEQRDQ Mflv_0405|M.gilvum_PYR-GCK CRATWHEAPLD-SETQVFDLEYLDRDGRHLGGVREFTVKRAPREALLRGL Mvan_0269|M.vanbaalenii_PYR-1 CRATWHTSELD-SETQVFDLDFLDRDGRHLGGIREFTVKRAPREALLRGL * : *:: ** * * : . . : Mb2965c|M.bovis_AF2122/97 LVSERLLTLGWQQRALPEVG---DGEAGSWLLIDTSNAVDTPDMLASTLT Rv2940c|M.tuberculosis_H37Rv LVSERLLTLGWQQRALPEVG---DGEAGSWLLIDTSNAVDTPDMLASTLT MLBr_00139|M.leprae_Br4923 QLSERLLTIGWQQRTLPESV---HVEPGSWLLIDTFNASAIPDMWASTLT MMAR_1767|M.marinum_M VLSERLLTLEWQQRQLPEVL---DEETGSWLLIS---ASDGEDLMATMLA MUL_2010|M.ulcerans_Agy99 VLSERLLTLEWQQRQLPEVL---DEETGSWLLIS---ASDGEDLMATTLA MAV_2370|M.avium_104 VLTERLLNIEWRQRELPEP---EHADAASWLLIGTT-ATADV--LASTLA TH_4621|M.thermoresistible__bu VLGERLLTIEWQRRDLPEA---DSA-AGKWLLVSTS-ATADV--SATRLS MSMEG_4727|M.smegmatis_MC2_155 LLDERLLTIEWQQRELPRPEGSETVDAGSWLVILAGDDDENP--RAAGVV MAB_3148c|M.abscessus_ATCC_199 LLNNRLLAIEWQQQRLPES---VSGAPRRWLLVSTG-ESVDP--WAAELI Mflv_0405|M.gilvum_PYR-GCK GGDATRLLYTLGWHEVPVPE-----------------SGDGAAPQGTWLI Mvan_0269|M.vanbaalenii_PYR-1 GGDATRLLYTLGWHEVPAPA-----------------SGD-AALNGNWLI * : :* . : Mb2965c|M.bovis_AF2122/97 DALKSHGPQGTECASLSWSVQDTPPNDQAGLEKLGSQLRGRD--GVVIVY Rv2940c|M.tuberculosis_H37Rv DALKSHGPQGTECASLSWSVQDTPPNDQAGLEKLGSQLRGRD--GVVIVY MLBr_00139|M.leprae_Br4923 DALKSYGTQGTECTNLSWLIQDDP---VVSRERLGRQLRGRD--GVVILC MMAR_1767|M.marinum_M DALKS---QGAECASMVWSAQDDLAG---GIEKLGAQLRARTNKGVVIVC MUL_2010|M.ulcerans_Agy99 DALKS---QGAECASMVWSAQDDLAG---GIEKLGAQLRARTNKGVVIVC MAV_2370|M.avium_104 DTLKN---HGAQCTTMAWPQQADHTA---HAEQLRNQWRGDGFTGVVVLT TH_4621|M.thermoresistible__bu DALKQ---AGAESTSMCWPQQADHAD---NVDRFR-AGIADGVTGVVVLT MSMEG_4727|M.smegmatis_MC2_155 SALIG---AGMPTTTMAWSHDADHDA---QAAALTARLDEQPLAGVAVIV MAB_3148c|M.abscessus_ATCC_199 DSLKV---RESEVSLIQWRPNTDRVA---ALKLLYDQLESGTFDGVLVVT Mflv_0405|M.gilvum_PYR-GCK GGFDELAVSVPGCIPADR-TNPESLR----QLLTDAHGRGLPFSGVVWRA Mvan_0269|M.vanbaalenii_PYR-1 AGFDELAAGVPGCIPFDRSTDPEPLG----QLLAQAHERGIGFSGVVWRA : : ** Mb2965c|M.bovis_AF2122/97 GP-RVGDPDE----HSLLAGREQVRHLVRITRELAEFEGELPRLFVVTRQ Rv2940c|M.tuberculosis_H37Rv GP-RVGDPDE----HSLLAGREQVRHLVRITRELAEFEGELPRLFVVTRQ MLBr_00139|M.leprae_Br4923 GP-RAGAPDE----QSLLAAREQVRHLVRIIRELAELEGELPRLFVVTRQ MMAR_1767|M.marinum_M GP-RSGDADE----QSLLQGREQVRHLVRITRELAELEGELPRLFVVTRQ MUL_2010|M.ulcerans_Agy99 GP-RSGDADE----QSLLQGREQVRHLVRITRGLAELEGELPRLFVVTRQ MAV_2370|M.avium_104 GP-KNGDNDQ----ESALLSRDHVQHLVRIARELTDLPGEPPRLYVVTRN TH_4621|M.thermoresistible__bu GP-KNGNPDD----AAARRGSDYVRHLVRITRELAEIDGDAPRLFVVTRG MSMEG_4727|M.smegmatis_MC2_155 GD-SETGTDAHDVGADARRGADHVRHLVRIARTLADAVGEPPRLYVVTHR MAB_3148c|M.abscessus_ATCC_199 APGSEGGADR-----VVLQGADQVRHLVRITRELVDLPGEPPRLFVVTRN Mflv_0405|M.gilvum_PYR-GCK ARSDGDESDA---EVAARLEAEIAELLGAVHTVQGGEVKLPGGLWIVTER Mvan_0269|M.vanbaalenii_PYR-1 AAPSADESST---AMAARIETEIADLLSAVHTVQNGAVKLPGGLWIVTER . . : . * : *::**. Mb2965c|M.bovis_AF2122/97 AQIVKPHDSGERANLEQAGLRGLLRVISSEHPMLRTTLIDVDEHTDVERV Rv2940c|M.tuberculosis_H37Rv AQIVKPHDSGERANLEQAGLRGLLRVISSEHPMLRTTLIDVDEHTDVERV MLBr_00139|M.leprae_Br4923 AQIVQ---SGDAANLEQAGLRGLLRVISSEHPMLRTTLVDVDEHTDVERV MMAR_1767|M.marinum_M AQRVR---PEDEINLEQAGLRGLLRVIGSEHPLLQTTQVDVDESTQAEQL MUL_2010|M.ulcerans_Agy99 AQRVR---PEDEINLEQAGLRGLLRVIGSEHPLLQTTQVDVDESTQAEQL MAV_2370|M.avium_104 AQTVLP---NDVPNLGQAGLRGLVRVIGMEHPQLGAGQIDVDESTDAQAL TH_4621|M.thermoresistible__bu AQAVLP---QDRPNLEQAGLRGLLRVIGAEHPHLRTTQIDIADDADLDRV MSMEG_4727|M.smegmatis_MC2_155 SQHVLD---TDEPYLEHSGLRGLIRVVGMEHPRLRATQIDVDDSTAHEAL MAB_3148c|M.abscessus_ATCC_199 AQTVVD---GDITNLEQAGLRGLVRVIGAEYPHLRVTHIDVDRHTAAQNV Mflv_0405|M.gilvum_PYR-GCK AVATES---GEPVDPVQAALWGFGRTAINEEPALRCRLVDCDGSPQAVQA Mvan_0269|M.vanbaalenii_PYR-1 AVATES---GEPVDPVQAALWGFGRTTINEEPALRCRLVDVDGSPEAVLA : . : ::.* *: *. * * * :* . Mb2965c|M.bovis_AF2122/97 AQQLLSGSEEDETAWRNGDWYVARLTPSPLGHEERRTAVLDPDHDGMRVQ Rv2940c|M.tuberculosis_H37Rv AQQLLSGSEEDETAWRNGDWYVARLTPSPLGHEERRTAVLDPDHDGMRVQ MLBr_00139|M.leprae_Br4923 AQQLLSGSEEDETAWRNGDWYVARLNPSPLSHEDRRTVVLNPEHDGLRVH MMAR_1767|M.marinum_M AQQLLGGSEEDETAWRGGEWYVARLFPGPLSADERQTTIVDHERDNMRLQ MUL_2010|M.ulcerans_Agy99 AQQLLGGSEEDETAWRGGEWYVARLFPGPLSADERQTTVVDHERDNMRLQ MAV_2370|M.avium_104 ARQLLAGSEEDETAWRDGAWYTARLCPAPLLPEERHTAVANHECDGMRLQ TH_4621|M.thermoresistible__bu AVQLLGGGAEDETAWRDGQWYTARLSLSPLRPEERKQAVVDCERDGMRLE MSMEG_4727|M.smegmatis_MC2_155 VRQLLSGSPEDETAWRDGQWYAARLCPSPLRAAERRTAVADNASEGMRLV MAB_3148c|M.abscessus_ATCC_199 AGELVSGSEEDETAWREDHWYRARLNLGPLGPDDWRSTVATPNNEGVRFE Mflv_0405|M.gilvum_PYR-GCK LAALLSTPVDE----PELAVRQGKLLASRLLPWSRSGHLTVPRGGDYVLA Mvan_0269|M.vanbaalenii_PYR-1 LAGLLAAPVDE----PELAVRQGKLLASRLLPWARSGHLTVPRSADYVLA *:. :: .:* . * : . . Mb2965c|M.bovis_AF2122/97 VRRPGDLQTLEFVASDRVPPGPGQIEVAVSMSSINFADVLIAFGRFPIID Rv2940c|M.tuberculosis_H37Rv VRRPGDLQTLEFVASDRVPPGPGQIEVAVSMSSINFADVLIAFGRFPIID MLBr_00139|M.leprae_Br4923 VRKPGDLQSLELVASDRVPPGPGQLEVAVSMSSINFADVLIAFGRFPIID MMAR_1767|M.marinum_M IRTPGDLQTLELAACDRVPPGPGQIEVAVTMSSINFADVLIAFGRYPSLE MUL_2010|M.ulcerans_Agy99 IRTPGDLQTLELAACDRVPPGPGQIEVAVTMSSINFADVLIAFGRYPSLE MAV_2370|M.avium_104 IRTPGDLESLELVACDRIPPGPGQIEVAVSASSINFADVLVAFGRYPAFE TH_4621|M.thermoresistible__bu IRTPGDLETMELAAFDRVPPGPGQIEVAVTASSINFADVLIAFGRYPTFD MSMEG_4727|M.smegmatis_MC2_155 VRNPGDLESMELVTFERGTPGPGQIEVAVKASSINFADVLVAFGRCPSFD MAB_3148c|M.abscessus_ATCC_199 VRTPGDLQSLGFVAFDRVAPGPGQIEVSVTATSINFADVLNVYGRYSSFE Mflv_0405|M.gilvum_PYR-GCK PTERGAIDNLRLTDSEVPPPAEGYVQVRVEAAGLNFRDVLNVLGLYP--- Mvan_0269|M.vanbaalenii_PYR-1 PTERGAIDNLRLTETDVAPPAEGYVQVRVEAAGLNFRDVLNVLGLYP--- * ::.: :. : .*. * ::* * :.:** *** . * . Mb2965c|M.bovis_AF2122/97 DREPQLGMDFVGVVTAVGEGVTGHQVGDRVGGFSEGGCWRTFLTCDANLA Rv2940c|M.tuberculosis_H37Rv DREPQLGMDFVGVVTAVGEGVTGHQVGDRVGGFSEGGCWRTFLTCDANLA MLBr_00139|M.leprae_Br4923 DRDPQLGMDFVGVVTAVGEGVTGHQIGDRVGGFSEGGCWRTFLTCDANLA MMAR_1767|M.marinum_M GRLPETGTDFVGVVTAVGEGVTDHQVGDRVGGFSKDGCWRSYLTCDANLA MUL_2010|M.ulcerans_Agy99 GRLPETGTDFVGVVTAVGEGVTDHQVGDRVGGFSKDGCWRSYLTCDANLA MAV_2370|M.avium_104 GRLPELGTDFAGVVTAVGPDVTDHKVGDHVGGLSANGCWGTFLTCDARLA TH_4621|M.thermoresistible__bu GRRPQLGTDFAGVVTAVGPDVTSHRVGDRVGGLSPNGCWSTFVTCDADLA MSMEG_4727|M.smegmatis_MC2_155 GRLPELGSEFGGVVTAVGPGVTTHRVGDRVGGVSANGCWSNFVTCEADLA MAB_3148c|M.abscessus_ATCC_199 GRQ-ELGVDFAGVVTAVGEGVTQHQVGDRVGGMTPTGAWRSFVVVDANLA Mflv_0405|M.gilvum_PYR-GCK GDPGPIGGDFAGTVTQLGEGVTGLDVGQRVYGSMQG-AFASRFNVPGQFL Mvan_0269|M.vanbaalenii_PYR-1 GDPGPIGGDFAGTVTQLGSGVTGLEVGQRVYGFMQG-AFASRFNVPAQLL . * :* *.** :* .** :*::* * .: . . . : Mb2965c|M.bovis_AF2122/97 VTLPPGLTDEQAITAATAHATAWYGLNDLAQIKAGDKVLIHSATGGVGQA Rv2940c|M.tuberculosis_H37Rv VTLPPGLTDEQAITAATAHATAWYGLNDLAQIKAGDKVLIHSATGGVGQA MLBr_00139|M.leprae_Br4923 VTLPSGLTDEQAITAATAHATAWYGLNDLAGIKVGDKVLIHSATGGVGQA MMAR_1767|M.marinum_M VTLPAGLSDEHAAASSTAHATAWYGLNDLAGIKAGDRVLIHSATGGVGQA MUL_2010|M.ulcerans_Agy99 VTLPAGLSDEHAAASSTAHATAWYGLNDLAGIKAGDRVLIHSATGGVGQA MAV_2370|M.avium_104 VTLPPGLADDQAAAVTTAHATAYYGLHELARIGAGDRVLIHSATGGVGQA TH_4621|M.thermoresistible__bu VPLPDGLTEGQAAAVSTAHATAWYGLHDLARLGAGEKVLIHSATGGVGLA MSMEG_4727|M.smegmatis_MC2_155 TKLPEGISEHEAAAVGLAYGTVWLGLTELARMSAGDKILIHSATGGVGQA MAB_3148c|M.abscessus_ATCC_199 ATLPAEVPDREAAAVPGAHVTAWYGLHELARISAGDKVLIHSGTGGVGQA Mflv_0405|M.gilvum_PYR-GCK APIPDGVSAVEAATIPAAALTVRLSF-DWAQVKSGDKVLIHAASGGVGLA Mvan_0269|M.vanbaalenii_PYR-1 APIPDGIGAVDAATIPAAALTARLAF-DWAQLKPGDRVLIHAASGGVGLA . :* : .* : * *. .: : * : *:::***:.:**** * Mb2965c|M.bovis_AF2122/97 AISIARAKGAEIFATAGNPAKRAMLRDMGVEHVYDSRSVEFAEQIRRDTD Rv2940c|M.tuberculosis_H37Rv AISIARAKGAEIFATAGNPAKRAMLRDMGVEHVYDSRSVEFAEQIRRDTD MLBr_00139|M.leprae_Br4923 AISIARAKGAEIFATAGNPTKRAMLHDLGIEHVYDSRSVEFAEQIRRDTD MMAR_1767|M.marinum_M AIAIARAAGAQIFATAGNAERRQLLNDMGIEHVYDSRSIEFADQIRRDTN MUL_2010|M.ulcerans_Agy99 AIAIARAAGAQIFATAGNAERRQLVNDMGIEHVYDSRSIEFADQIRRDTN MAV_2370|M.avium_104 AIAIARAAGAEIFATAGSEQRRQLLRDMGIEHVYDSRTVEFADLIRHDTD TH_4621|M.thermoresistible__bu AIAIARSVGAQIYATAGSPARRDLLRDMGIEHVYDSRSTAFADEIRRDTD MSMEG_4727|M.smegmatis_MC2_155 AIAVARAAGAEIYATAGSEKRRQLLRDWGIEHVYDSRTTAFADQIRTDTD MAB_3148c|M.abscessus_ATCC_199 AIAIARAAGAEIYATAGSPERRDLLRSWGIKHVYDSRSTDFAELIRRDTD Mflv_0405|M.gilvum_PYR-GCK AVQMAQQCGAEVYATAS-TFKRATLRKLGVKHVYDSRTTDFAEQILADTD Mvan_0269|M.vanbaalenii_PYR-1 AIQMAQQHGAVVFATAS-TYKRATLRKLGVDHVYDSRTTEFADQILADTD *: :*: ** ::***. :* :.. *:.******: **: * **: Mb2965c|M.bovis_AF2122/97 GYGVDIVLNSLT-GAAQRAGLELLAFGGRFVEIGKADVYGNTRLGLFPFR Rv2940c|M.tuberculosis_H37Rv GYGVDIVLNSLT-GAAQRAGLELLAFGGRFVEIGKADVYGNTRLGLFPFR MLBr_00139|M.leprae_Br4923 GYGVDIVLNSLT-GAAQRAGLELLTFGGRFVEIGKADVYGNTRLGLFPFR MMAR_1767|M.marinum_M GYGVDIVLNSLT-GAAQRAGLELLAFGGRFVEIGKADVYGNTRMGLYPFR MUL_2010|M.ulcerans_Agy99 GYGVDIVLNSLT-GAAQRAGLELLAFGGRFVEIGKADVYGNTRMGLYPFR MAV_2370|M.avium_104 GYGVDIVLNSVT-GAAQRAGIELLAFGGRFVEIGKRDIYGDTRLGLLPFR TH_4621|M.thermoresistible__bu GYGVDVVLNSLP-GAAQRAGLELLSFGGRFIEIGKRDIYGDTRLGLFPFR MSMEG_4727|M.smegmatis_MC2_155 GYGVDIVLNSVT-GPAQRAGLELLAFGGRFVEIGKRDIYADTRLGLFPFR MAB_3148c|M.abscessus_ATCC_199 GYGVDIVLNSLT-GAAQRAGVELLTFGGRFIEIGKRDIYGDTRLGLFPFR Mflv_0405|M.gilvum_PYR-GCK GAGVDVVLNSLTSEGFIEATLRATAQHGRFAEIAKRDIWTVEQMAAA--R Mvan_0269|M.vanbaalenii_PYR-1 GEGVDVVLNSLTNEGFIEATVRATAQNGRFAEIAKRDIWTPEQMAAA--R * ***:****:. .* :. : *** **.* *:: ::. * Mb2965c|M.bovis_AF2122/97 RGLTFYYLDLALMSVTQPDRVRELLATVFKLTADG------VLTAPQCTH Rv2940c|M.tuberculosis_H37Rv RGLTFYYLDLALMSVTQPDRVRELLATVFKLTADG------VLTAPQCTH MLBr_00139|M.leprae_Br4923 RGLTFYYLDLALMSVTQPDRVRELLATVFNLTADG------VLTAPECTH MMAR_1767|M.marinum_M RGLTFYYVDLGLMSVIQPERVRELLSTVYNLTAEG------VLSAPECTH MUL_2010|M.ulcerans_Agy99 RGLTFYYVDLGLMSVIQPERVRELLSTVYNLTAEG------VLSAPECTH MAV_2370|M.avium_104 RNLTFYALDLALMSFSHPDRLRGLLRTVYRLTADG------ALPMPESTH TH_4621|M.thermoresistible__bu RNLAFHGVDLGLMADSHPHKIRELLETVYRLTADG------VLPMPQSTH MSMEG_4727|M.smegmatis_MC2_155 RNLSFYAVDLALMTVTHPQKIRDLLATVYRLIADG------TLPLPEITH MAB_3148c|M.abscessus_ATCC_199 RNLSFHAVDLVLVAKTRPEAIYRTLTALYGQMAEG------VLPLPEISP Mflv_0405|M.gilvum_PYR-GCK PDLAYEIVALDTVMFTEPDRIRDLLTEVSAGLRDG------AWTPLPAEV Mvan_0269|M.vanbaalenii_PYR-1 PDIAYEIVALDTVTLLEPERIRGLLGEVSDGLGKADGSSRAEWVPLPAEI .::: : * : .*. : * : .. Mb2965c|M.bovis_AF2122/97 YPLAEAADAIRAMSNAEHTGKLVLDVPRSGRRSVAVTPEQAPLYRRDGSY Rv2940c|M.tuberculosis_H37Rv YPLAEAADAIRAMSNAEHTGKLVLDVPRSGRRSVAVTPEQAPLYRRDGSY MLBr_00139|M.leprae_Br4923 YPLTDAANAIRAMSNAEHTGKLVLDIPRTGSRSVAVPPEQAPVYRRDGSY MMAR_1767|M.marinum_M YPLAEAAEAIRTMSNAAHTGKLLLDMPRSGRRGVVVPPEQVEVFRGDGSY MUL_2010|M.ulcerans_Agy99 YPLAEAAEAIRTMSNAAHTGKLLLDMPRSGRRGVVVPPEQVEVFRGDGSY MAV_2370|M.avium_104 YPLADAASAIRVMSAAQHTGKLVLDVPHAGRSRVVVPPAQVRAFRSDGAY TH_4621|M.thermoresistible__bu YPLAEAATAIRVMSAAEHVGKLVLDVPHTGRADVVVPPEQASPFRSDGAY MSMEG_4727|M.smegmatis_MC2_155 YPLEEAATAIRIMGGAQHTGKLVIDIPDTGQSQVVVPPEQVPVFRGDGAY MAB_3148c|M.abscessus_ATCC_199 SPLQEAAESIRVMGAAGHTGKLVLDLPKAGEVSAVIPPSHAPAFRRDGAY Mflv_0405|M.gilvum_PYR-GCK YPLTEARAAFRRMQQARHIGKIVVQIPNPLQP------------QPDRSY Mvan_0269|M.vanbaalenii_PYR-1 YPLTEARAAFRRMQQARHVGKIVLQMPKPLQP------------RADRSY ** :* ::* * * * **:::::* . : * :* Mb2965c|M.bovis_AF2122/97 IITGGLGGLGLFFASKLAAAG----CGRIVLTARSQPNPKARQTIEGLRA Rv2940c|M.tuberculosis_H37Rv IITGGLGGLGLFFASKLAAAG----CGRIVLTARSQPNPKARQTIEGLRA MLBr_00139|M.leprae_Br4923 IITGGLGGLGLFFASKLAEAG----CGRIVLTARSQPNPKARQTIERLCA MMAR_1767|M.marinum_M IITGGLGGLGLFFASKMAAAG----CGRIVLTARSQPNPKSRQAIERLRA MUL_2010|M.ulcerans_Agy99 IITGGLGGLGLFFASKMAAAG----CGRIVLTARSQPNPKSRQAIERLRA MAV_2370|M.avium_104 IVTGGLGGLGLFLAEKMASPGSRAGCGRIVLCSRALPNPKALATLERIRQ TH_4621|M.thermoresistible__bu IVTGGMGGLGLYLAGEMAAAG--AGC--IVLNGRSAPSGEALRTIEQLRA MSMEG_4727|M.smegmatis_MC2_155 VITGGLGGLGLFLAERMAAAG----CGRIVVNSRSAPSTRSSEIIELIRA MAB_3148c|M.abscessus_ATCC_199 VVTGGLGGLGLFLARKLAAAG----VGRIILNGRSAPKPEALAAIEQIRQ Mflv_0405|M.gilvum_PYR-GCK LITGGLGAIGLHTAGYLAQLG----AGDIVLTSRRAPDAAAQQAIADIAD Mvan_0269|M.vanbaalenii_PYR-1 LITGGLGAIGLHTAAYLAQLG----AGDLVLTSRRAPDADARRAIEEITE ::***:*.:**. * :* * ::: .* *. : : : Mb2965c|M.bovis_AF2122/97 -AGADIVVECGNIAEPDTADRLVSAATATGLPLRGVLHSAAVVEDATLTN Rv2940c|M.tuberculosis_H37Rv -AGADIVVECGNIAEPDTADRLVSAATATGLPLRGVLHSAAVVEDATLTN MLBr_00139|M.leprae_Br4923 -AGADIVVECGNIAEPYTADRLVNAATATGLPLRGVLHSAAVVEDATLTN MMAR_1767|M.marinum_M -NGADIVVECGNIAEPETADRLVSAATATGLPLRGVLHAAAVVEDATLSN MUL_2010|M.ulcerans_Agy99 -NGADIVVECGNIAEPETADRLVSAATATGLPLRGVLHAAAVVEDATLSN MAV_2370|M.avium_104 -MGADIVVERGDIAEAGTAQRLLDVATATGLPVRGVLHLAAVIEDATLAN TH_4621|M.thermoresistible__bu -AGTEVIVECGXXXRG----QPVEVAVPT------ELRHADEHPDRRGAQ MSMEG_4727|M.smegmatis_MC2_155 -TGADIVVECGDIAEPDTALRLVAAATQTGLPLRGVLHAAAVVEDATLAN MAB_3148c|M.abscessus_ATCC_199 -GGTEIDVALGDIAEPDTAQRLVAAATETGKPVRGVLHAAALVHDATLAN Mflv_0405|M.gilvum_PYR-GCK RTKARLHVFTADVGVEADVAALLERIRAELPPLAGVAHLAGVLDDALLSQ Mvan_0269|M.vanbaalenii_PYR-1 RYKCRVHTFCADVGDESQVAELLARIRAELPPLAGVAHLAGVLDDALLSQ : . . : : * * :: Mb2965c|M.bovis_AF2122/97 ITDELIDR-DWSPKVFGSWNLHRATLGQP-----LDWFCLFSSGAALLGS Rv2940c|M.tuberculosis_H37Rv ITDELIDR-DWSPKVFGSWNLHRATLGQP-----LDWFCLFSSGAALLGS MLBr_00139|M.leprae_Br4923 ITDELIDR-DWSPKVYGSWNLHCATIGQP-----LDWFCLFSSGAALLGS MMAR_1767|M.marinum_M ITDELIDR-DWSPKVYGSWNLHRASTGQP-----LDWFCLFSSGAALMGS MUL_2010|M.ulcerans_Agy99 ITDELIDR-DWSPKVYGSWNLHRASTGQP-----LDWFCLFSSGAALMGS MAV_2370|M.avium_104 ITDELIER-DWAAKVYGAWNLHCALQESG-AEQSLDWFCSFSSAAALVGS TH_4621|M.thermoresistible__bu LCDEFARG-EQGAQR----NQHRTDAGEG-QRD--------AHPPGAVGH MSMEG_4727|M.smegmatis_MC2_155 ITDELVEH-DWAPKVYGAWNLHQAVQSGGPATSELDWFCAFSSAAALVGS MAB_3148c|M.abscessus_ATCC_199 ITDELIDRGDWRPKVHGAWNLHEATADQP-----LDWFCSFSSIAALVGS Mflv_0405|M.gilvum_PYR-GCK QSVERFRT-ALAPKAFGAVHLDRLTRVDD-----LDFFLVSSSVSSLFGS Mvan_0269|M.vanbaalenii_PYR-1 QSLERFRT-TLAPKAFGACHLDRLTAGDD-----LDFFIMSSSVSSLFGS * .: : . : .. .* Mb2965c|M.bovis_AF2122/97 PGQGAYAAANSWVDVFAHWRRAQGLPVSAIAWGAWGEVGRATFLAEGGEI Rv2940c|M.tuberculosis_H37Rv PGQGAYAAANSWVDVFAHWRRAQGLPVSAIAWGAWGEVGRATFLAEGGEI MLBr_00139|M.leprae_Br4923 PGQGAYAAANSWVDLFAHWRRAQGLPVSAIAWGAWGEVGRATFLAEGGEI MMAR_1767|M.marinum_M PGQGAYAAANSWVDAFAHWRRAQGLPVCAIGWGAWGEVGRATFLAEGGEI MUL_2010|M.ulcerans_Agy99 PGQGAYAAANSWVDAFAHWRRAQGLPVCAIGWGAWGEVGRATFLAEGGEI MAV_2370|M.avium_104 PGQGAYAAANSWLDAFTRWRRARGLKATAIAWGAWAQIGRGAALADSADV TH_4621|M.thermoresistible__bu DQPDPGALSDTGLDERGGQFPGVGVQIPVADPGVGIDH-RGAVRVDSGVP MSMEG_4727|M.smegmatis_MC2_155 PGQGAYAAANSWLDAFMQWRRAQGLPATSIAWGAWGEIGRGTAMAE-GDN MAB_3148c|M.abscessus_ATCC_199 PGQGAYAAANSWLDGFTHWRRAQGLPATVIAWGAWSEIGQGTHLAQNAEA Mflv_0405|M.gilvum_PYR-GCK PGQSNYATANAFLDGLVAQRRAQGLPATGVNFGPWARGGMASSEAAAANI Mvan_0269|M.vanbaalenii_PYR-1 PGQANYATANALLDGLTAHRRARGLPATGVNFGPWAQGGMASSEAATANI * ::: :* . *: * .: . . Mb2965c|M.bovis_AF2122/97 MIT---PEEGAYAFETLVRHDRAYSGYIPILGAPWLADL-----VRRSPW Rv2940c|M.tuberculosis_H37Rv MIT---PEEGAYAFETLVRHDRAYSGYIPILGAPWLADL-----VRRSPW MLBr_00139|M.leprae_Br4923 MIT---PDEGAYAFEMLVRYDRPYSGYIPILGAPWLPDL-----VRRSPW MMAR_1767|M.marinum_M MIA---PDEGMYAFEQMLRHARTYTGYIPIIGAPWLADL-----VRRSPW MUL_2010|M.ulcerans_Agy99 MIA---PDEGMYAFEQMLRHARTYTGYIPIIGAPWLADL-----VRRSPW MAV_2370|M.avium_104 AIT---PDEGAYAFEALLRHDRACTGYAPITGTPWLTAF-----AQRSPF TH_4621|M.thermoresistible__bu AQQ---GVDGEVVRHRTLSSVRSGR-------SSRWTAP-----GSR--C MSMEG_4727|M.smegmatis_MC2_155 AIA---PDEGAYAFEAILRHDRVYNGYAPVLGASWLTAF-----AQRSPF MAB_3148c|M.abscessus_ATCC_199 AIL---PDEGAYAFDTVLRHNRAYTAYAPMAGISWLADF-----VERSPF Mflv_0405|M.gilvum_PYR-GCK SAQGLIPLEPSAALTAMAEVVANGTAQATVLKANWQRAAKVLGSSRPPIL Mvan_0269|M.vanbaalenii_PYR-1 GAQGLVPLEPSAALGALAEVLANGTGQAAVLKANWQRAAKVLGSSRPPIL : . Mb2965c|M.bovis_AF2122/97 GEMFASTGQRSRGPSKFRMELLSLPQDEWAGRLRRLLVEQASVILRRTID Rv2940c|M.tuberculosis_H37Rv GEMFASTGQRSRGPSKFRMELLSLPQDEWAGRLRRLLVEQASVILRRTID MLBr_00139|M.leprae_Br4923 AEMFSSAGQGSRGPSKFRMELLALPQDEWSGRLRRLLVEQASVILRRTID MMAR_1767|M.marinum_M AEMFQSSGQNTRGPSKFLAELKLLPQEEWAGRLRRLIAEQASVILRRTVD MUL_2010|M.ulcerans_Agy99 AEMFQSSGQNTRGPSKFLAELKLLPQEEWAGRLRRLIAEQASVILRRTVD MAV_2370|M.avium_104 AEAFRANGQSATGTSKLRAELEELPPEEWSTRLRRLISDQVSLILRRNVD TH_4621|M.thermoresistible__bu GSGRRYGGESCRRTTGPAAGAAARRGR-----------------TRRRRR MSMEG_4727|M.smegmatis_MC2_155 AELFLADTQGASETRKLRSELAALPREEWPTHLRRLIAEQVGLLLRRTVD MAB_3148c|M.abscessus_ATCC_199 AQAFRDAGQNQTETNKFLDELRALPREEWPTRLRKLVAEQVGLVLRRSID Mflv_0405|M.gilvum_PYR-GCK DLVLPSAVGEITGDSELLKQLQEIPVPQRAGFVTEFLQKEVQNFLRLAQP Mvan_0269|M.vanbaalenii_PYR-1 DLVLPRPEGEVAGDSELLRQLQEIPVAQRAGFVTEFLQREVQNFLRLAQP * Mb2965c|M.bovis_AF2122/97 ADRS--FIEYGLDSLGMLEMRTHVETETGIRLTP--KVIATNNTARALAQ Rv2940c|M.tuberculosis_H37Rv ADRS--FIEYGLDSLGMLEMRTHVETETGIRLTP--KVIATNNTARALAQ MLBr_00139|M.leprae_Br4923 ADRS--FIEYGLDSLGMLEMRTHIESETGIRLTP--KVIATNNTARALAQ MMAR_1767|M.marinum_M ADRP--FVEYGLDSLGMLEMRTHIETETGVRLSP--KVIASHNTARALSQ MUL_2010|M.ulcerans_Agy99 ADRP--FVEYGLDSLGMLEMRTHIETETGVRLSP--KVIASHNTARALSQ MAV_2370|M.avium_104 PDRP--LPEYGLDSLGGLELLTRIQTETGIRVSP--ADIAAIGTIRGLAD TH_4621|M.thermoresistible__bu PRRP--PPPP-----------DRVRHRAGP----------AHGPVRR--- MSMEG_4727|M.smegmatis_MC2_155 PDRP--LSEYGLDSLGHLELRTRIETETGVRVS-----AMDMTTIRGLAQ MAB_3148c|M.abscessus_ATCC_199 PDRS--LPDYGLDSLGNLEIRTRIQADTGVRIG-----PADVSTVRSLAA Mflv_0405|M.gilvum_PYR-GCK PAATSRFLDLGTDSLMAIELRNRLHSQFGGAFTINATAVFDYPTIGGLAE Mvan_0269|M.vanbaalenii_PYR-1 PAATSRFLDLGTDSLMAIELRNRLHSQFGGAFTINATAVFDYPTIGGLAE . . ::. * . Mb2965c|M.bovis_AF2122/97 YLADTLAEEQAAAPAAS-------------------- Rv2940c|M.tuberculosis_H37Rv YLADTLAEEQAAAPAAS-------------------- MLBr_00139|M.leprae_Br4923 YLADTLAEEEGVAAPAAMVSPETP------------- MMAR_1767|M.marinum_M HLADTLAEEEAQPAAS--------------------- MUL_2010|M.ulcerans_Agy99 HLADTLAEEEAQPAAS--------------------- MAV_2370|M.avium_104 LLRDKLTPAGAAQAERV-------------------- TH_4621|M.thermoresistible__bu ------------------------------------- MSMEG_4727|M.smegmatis_MC2_155 RLCEMLDTDDAVSAPS--------------------- MAB_3148c|M.abscessus_ATCC_199 HIYDRLAEQESEVASS--------------------- Mflv_0405|M.gilvum_PYR-GCK YLVAQLPD-----AETPQAAPQSESEPGPDVTE---- Mvan_0269|M.vanbaalenii_PYR-1 YLVGQLPDSDAAAGETPATETSPIDHNHPDREADSPG