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M. tuberculosis H37Rv Rv1484 (inhA)

annotation: enoyl-(acyl carrier protein) reductase
coordinates: 1674202 - 1675011
length: 269

MTGLLDGKRILVSGIITDSSIAFHIARVAQEQGAQLVLTGFDRLRLIQRITDRLPAKAPLLELDVQNEEH
LASLAGRVTEAIGAGNKLDGVVHSIGFMPQTGMGINPFFDAPYADVSKGIHISAYSYASMAKALLPIMNP
GGSIVGMDFDPSRAMPAYNWMTVAKSALESVNRFVAREAGKYGVRSNLVAAGPIRTLAMSAIVGGALGEE
AGAQIQLLEEGWDQRAPIGWNMKDATPVAKTVCALLSDWLPATTGDIIYADGGAHTQLL
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. tuberculosis H37RvRv1484inhA-100% (269)enoyl-(acyl carrier protein) reductase
M. tuberculosis H37RvRv3530c-1e-0826.63% (199) short chain dehydrogenase
M. tuberculosis H37RvRv3559c-8e-0724.53% (265) short chain dehydrogenase

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb1520inhA1e-152100.00% (269) enoyl-(acyl carrier protein) reductase
M. gilvum PYR-GCKMflv_3657-1e-13588.72% (266) enoyl-(acyl carrier protein) reductase
M. leprae Br4923MLBr_01806inhA1e-13790.33% (269) enoyl-(acyl carrier protein) reductase
M. abscessus ATCC 19977MAB_2722c-1e-13787.73% (269) enoyl-(acyl carrier protein) reductase
M. marinum MMMAR_2290inhA1e-14492.94% (269) enoyl-
M. avium 104MAV_3294-1e-13789.59% (269) enoyl-(acyl carrier protein) reductase
M. smegmatis MC2 155MSMEG_3151-1e-13687.36% (269) enoyl-(acyl carrier protein) reductase
M. thermoresistible (build 8)TH_1379inhA1e-12882.96% (270) NADH-DEPENDENT ENOYL-
M. ulcerans Agy99MUL_1492inhA1e-14492.94% (269) enoyl-(acyl carrier protein) reductase
M. vanbaalenii PYR-1Mvan_2753-1e-13385.50% (269) enoyl-(acyl carrier protein) reductase

CLUSTAL 2.0.9 multiple sequence alignment


Rv1484|M.tuberculosis_H37Rv         MTGLLDGKRILVSGIITDSSIAFHIARVAQEQGAQLVLTGFDRLRLIQRI
Mb1520|M.bovis_AF2122/97            MTGLLDGKRILVSGIITDSSIAFHIARVAQEQGAQLVLTGFDRLRLIQRI
MMAR_2290|M.marinum_M               MAGLLEGKRILVSGIITDSSIAFHIARVAQEQGAQLVLTGFDRMRLIQRI
MUL_1492|M.ulcerans_Agy99           MAGLLEGKRILVSGIITDSSIAFHIARVAQEQGAQLVLTGFDRMRLIQRI
MLBr_01806|M.leprae_Br4923          MAGLLEGKRILVSGIITDSSIAFHIAKVAQEAGAQLVLTGFDRLRLIQRI
MAV_3294|M.avium_104                MAGLLDGKRILVTGIITDSSIAFHIAKVAQEAGAQLVLTGFDRLRLIQRI
Mflv_3657|M.gilvum_PYR-GCK          MT-LLQGKRILVTGIITDSSIAFHIAKVAQEAGAELVLTGFDRMKLIQRI
Mvan_2753|M.vanbaalenii_PYR-1       MTGILEGKRILVTGIITDSSIAFYIAKVAQEAGAEVICTGFNRLRLIERI
MSMEG_3151|M.smegmatis_MC2_155      MTGLLEGKRILVTGIITDSSIAFHIAKVAQEAGAELVLTGFDRLKLVKRI
MAB_2722c|M.abscessus_ATCC_199      MAGLLEGKRILVTGIITDSSIAFHIAKVAQEQGAELVLTGFDRLRLIERI
TH_1379|M.thermoresistible__bu      MAGFLEGKRILVTGIITDSSIAFHIARVAQEAGAEIVCTGFDRLRLIRRI
                                    *: :*:******:**********:**:**** **::: ***:*::*:.**

Rv1484|M.tuberculosis_H37Rv         TDRLPAK-APLLELDVQNEEHLASLAGRVTEAIGAGNKLDGVVHSIGFMP
Mb1520|M.bovis_AF2122/97            TDRLPAK-APLLELDVQNEEHLASLAGRVTEAIGAGNKLDGVVHSIGFMP
MMAR_2290|M.marinum_M               VDRLPQK-APLIELDVQNEEHLASLAGRVTEVIGEGNNLDGVVHSIGFMP
MUL_1492|M.ulcerans_Agy99           VDRLPQK-APLIELDVQNEEHLASLAGRVTEVIGEGNNLDGVVHSIGFMP
MLBr_01806|M.leprae_Br4923          ADRLPDK-APLIELDVQNEEHLATLAERVTAEIGEGNKLDGVVHSIGFMP
MAV_3294|M.avium_104                VDRLPEK-APLIELDVQNEEHLNTLAQRVTAEIGEGNKLDGVVHSIGFMP
Mflv_3657|M.gilvum_PYR-GCK          ADRLPEK-APLLELDVQNSEHLDSLADRVSEVIGEGNKLDGVVHSIGFMP
Mvan_2753|M.vanbaalenii_PYR-1       LERLPSK-PPLLELDVQDEKHLDTLADRITEVIGDGNKLDGVVHSIGFMP
MSMEG_3151|M.smegmatis_MC2_155      ADRLPKP-APLLELDVQNEEHLSTLADRITAEIGEGNKIDGVVHSIGFMP
MAB_2722c|M.abscessus_ATCC_199      TQRLPKP-APLLELDVQNEEHLGSLAGRISEVIGEGNKLDGVVHSIGFMP
TH_1379|M.thermoresistible__bu      VDRLPKPGAPLLELDVQNQEHLDTLADRITAEIGEGNKLDGVVHSIGFMP
                                     :***   .**:*****:.:** :** *::  ** **::***********

Rv1484|M.tuberculosis_H37Rv         QTGMGINPFFDAPYADVSKGIHISAYSYASMAKALLPIMNPGGSIVGMDF
Mb1520|M.bovis_AF2122/97            QTGMGINPFFDAPYADVSKGIHISAYSYASMAKALLPIMNPGGSIVGMDF
MMAR_2290|M.marinum_M               QSGMGINPFFDAPYEDVSKGIHISAYSYASLAKALLPIMNPGGSIVGMDF
MUL_1492|M.ulcerans_Agy99           QSGMGINPFFDAPYEDVSKGIHISAYSYASLAKALLPIMNPGGSIVGMDF
MLBr_01806|M.leprae_Br4923          QTGMGTNQFFDAPYEDVSKGIHISTYSYASLAKALLLIMNSGGSIVGMDF
MAV_3294|M.avium_104                QTGMGINPFFDAPYEDVSKGIHISAYSYASLAKALLPIMNPGGSIVGMDF
Mflv_3657|M.gilvum_PYR-GCK          QTGMGINPFFDAPYEDVAKGIHISAYSYASLAKAVLPIMNPGGGIVGMDF
Mvan_2753|M.vanbaalenii_PYR-1       QTGMGINPFFDAPYEDVAKGIHISAYSYASLAKAVLPIMNPGGGIVGMDF
MSMEG_3151|M.smegmatis_MC2_155      QSGMGINPFFDAPYEDVSKGIHISAYSYASLAKAVLPIMNPGGGIVGMDF
MAB_2722c|M.abscessus_ATCC_199      QSGMGVNPFFDAPFADVSKGFHISAFSYSSLAKAVLPVMNRGGSIVGMDF
TH_1379|M.thermoresistible__bu      QSGMGLNPFLDTPYEDVSKGIHISAYSYAALAKATLPIMNRGGSIVGMDF
                                    *:*** * *:*:*: **:**:***::**:::*** * :** **.******

Rv1484|M.tuberculosis_H37Rv         DPSRAMPAYNWMTVAKSALESVNRFVAREAGKYGVRSNLVAAGPIRTLAM
Mb1520|M.bovis_AF2122/97            DPSRAMPAYNWMTVAKSALESVNRFVAREAGKYGVRSNLVAAGPIRTLAM
MMAR_2290|M.marinum_M               DPTRAMPAYNWMTVAKSALESVNRFVAREAGKYGVRSNLVAAGPIRTLAM
MUL_1492|M.ulcerans_Agy99           DPTRAMPAYNWMTVAKSALESVNRFVAREAGKYGVRSNLVAAGPIRTLAM
MLBr_01806|M.leprae_Br4923          DPTRAMPAYNWMTVAKSALESVNRFVAREAGKYGVRSNLVAAGPIRTLAM
MAV_3294|M.avium_104                DPSRAMPAYNWMTVAKSALESVNRFVAREAGPHGVRSNLVAAGPIRTLAM
Mflv_3657|M.gilvum_PYR-GCK          DPTRAMPAYNWMTVAKSALESVNRFVAREAGKVGVRSNLVAAGPIRTLAM
Mvan_2753|M.vanbaalenii_PYR-1       DPTRAMPAYNWMTVAKSALESVNRFVAREAGKVGVRSNLVAAGPIRTLAM
MSMEG_3151|M.smegmatis_MC2_155      DPTRAMPAYNWMTVAKSALESVNRFVAREAGKVGVRSNLVAAGPIRTLAM
MAB_2722c|M.abscessus_ATCC_199      DPTRAMPAYNWMTVAKSALESVNRFVAREAGKVGVRSNLVAAGPIRTLAM
TH_1379|M.thermoresistible__bu      DPTRAMPAYNWMTVAKSALESINRFVAREAGQYGVRSNLVAAGPIRTLAM
                                    **:******************:*********  *****************

Rv1484|M.tuberculosis_H37Rv         SAIVGGALGEEAGAQIQLLEEGWDQRAPIGWNMKDATPVAKTVCALLSDW
Mb1520|M.bovis_AF2122/97            SAIVGGALGEEAGAQIQLLEEGWDQRAPIGWNMKDATPVAKTVCALLSDW
MMAR_2290|M.marinum_M               SAIVGGALGEEAGAQIQLLEDGWDQRAPVGWNMKDPTPVAKTVCAVLSEW
MUL_1492|M.ulcerans_Agy99           SAIVGGALGEEAGAQIQLLEDGWDQRAPVGWNMKDPTPVAKTVCAVLSEW
MLBr_01806|M.leprae_Br4923          SAIVGGAFGEEAGAQMQLLEEGWDQRAPIGWNMKDPTPVAKTVCALLSEW
MAV_3294|M.avium_104                AGIVGGVLGDQAAEQIRLLEEGWDQRAPIGWNMKDPTPVAKTVCALLSDW
Mflv_3657|M.gilvum_PYR-GCK          SAIVGGALGDEAGAQMQLLEEGWDQRAPLGWNMKDPTPVAKTVCALLSDW
Mvan_2753|M.vanbaalenii_PYR-1       SAIVGGALGEEAGAQMQLLAEGWDQRAPLGWNMKDPTPVAKTVCALLSDW
MSMEG_3151|M.smegmatis_MC2_155      SAIVGGALGDEAGQQMQLLEEGWDQRAPLGWNMKDPTPVAKTVCALLSDW
MAB_2722c|M.abscessus_ATCC_199      SAIVGGALGDEAGQQMQLLEEGWDQRAPIGWDMKDPTPVAKTVCALLSDW
TH_1379|M.thermoresistible__bu      SAIVGGALGEEAGEQMKLLEEGWDQRAPLGWDMKDPTPVAKTVLALISDW
                                    :.****.:*::*. *::** :*******:**:***.******* *::*:*

Rv1484|M.tuberculosis_H37Rv         LPATTGDIIYADGGAHTQLL
Mb1520|M.bovis_AF2122/97            LPATTGDIIYADGGAHTQLL
MMAR_2290|M.marinum_M               LPATTGDIIFADGGAHTQLL
MUL_1492|M.ulcerans_Agy99           LPATTGDIIFADGGAHTQLL
MLBr_01806|M.leprae_Br4923          LPATTGSIIYADGGASTQLL
MAV_3294|M.avium_104                LPATTGTIIYADGGASTQLL
Mflv_3657|M.gilvum_PYR-GCK          LPATTGTVIFADGGASTQLL
Mvan_2753|M.vanbaalenii_PYR-1       LPATTGTVIFADGGASTQLL
MSMEG_3151|M.smegmatis_MC2_155      LPATTGTVIYADGGASTQLL
MAB_2722c|M.abscessus_ATCC_199      LPATTGDIIFADGGAHTQLL
TH_1379|M.thermoresistible__bu      MPATTGTVIYADGGASQQLL
                                    :***** :*:*****  ***