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SFVIATPEMLTTAATDLAKIGSTITAANTAAAAVAKVLPASADEVSVAVAALFGTHAQEYQTVSAQVATF HDRFVQTLSAAASSYVAAEAVNVEQSLLAAVNAPTQALFGRPLIGNGADGSPGTGQAGGPGGILYGNGGN GGSGAPGQRGGAGGAAGLIGNGGNGGAGGVGTTGGAGGHGGAGGWLYGNGGAGGFGGAGAVGGNGGAGGT AGLFGVGGAGGAGGNGIAGVTGTSASTPGGSGTAGGAGGIGGNGGAGGAGGVLMGNGGNGGAGGEGGPGG AGGAGASGAHATNLGADGQAGGNGGNGGAGGTGGVGGPGGGHGLLGLGGSHGAGGAGGSGGDGGAPGDGG NGATGTWGHNLGAGGTGGNGGNPGAGGAGGAGGASVGGSAHGANGAPGTTSTSGGNGGDGGKGADAISSG QTGANGGRGGDGGQVGNGGAGGAGGRGGAGGLGFGSEAPGRPGGAGGTGGAGGNGGTQAGDGGTGGAGGA GGDGGSGGAGSIGFNASAPGAAGSPGGNGGNGGPGGAGGEGGAGGLALAASGQNGSQGAGGDGGAGGNGG TPGNGGHGAAGALGVNGGVGGAGGHGGDPGVGGAGGQGGSGSTPGANGAPGNTPTSGGNGGNGGRGADAT GFGQTGASGGRGGDGGLVGNGGAGGAGGNGSKGLPGLGRLGNPGLDGGTGGNGGAGGSGGAWAGNGGTGG AGGTGGVGGTGGSGSDGVNGSSAGADGHPGGTGGVGGTGGKGGDGGDGGAAPNGVAGSQGPGGAGGDGGT GGVGGNGGRGIDGADGATAGARGQDGGAGGAGGKGGRGGTGGPGGAGPAGTTGSQGAGGNGGSGGTGGDP GDGGNGANGSVFTNNGIGGNGGNGGNAGPSGAGGSGGAGSTFGATGSSSSIHVNGGNGGNGGNGDHALSG NGAAGGNGGNGGNGSLRGSGGAGGHGGNGGNASRGMGGDGGTGGAGGNAGQIGNGGAGGNGGDGGTGSDG NPGAITGSGGRGGDGGVGGQGGSVAGDGADGGRGGAGGTGGTGLRGTTGATGATGTFDAGADGHGGNGGT GGVGGTGGAGGGGGNGGAGGKALSPTGNNGSQGAGGDGGAGGAGGTGGTGGDGGRGAHGTLFSSLAGTGG TGGNGGTGGTGGTGGAGGAGGTGSTLGATGATGAAGRAGNGGVGGSGGLGSAFGPGGTGGMGGAGGTSTV SAGGDGGRGGFGGDGLDASSGGNGGDGGHGGDGFRTAGAGGRGGDGGKGADPGGLFPIPGAGGKGGTGGT GGTAHLGPLAIIGQSGQPGQFGSPGADGRGGAGGAGGGGGAGGSF*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv0578c | PE_PGRS7 | - | 100% (1306) | PE-PGRS FAMILY PROTEIN |
| M. tuberculosis H37Rv | Rv2490c | PE_PGRS43 | 0.0 | 52.13% (1479) | PE-PGRS family protein |
| M. tuberculosis H37Rv | Rv3514 | PE_PGRS57 | 0.0 | 51.49% (1439) | PE-PGRS family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0593c | PE_PGRS7 | 0.0 | 99.92% (1306) | PE-PGRS family protein |
| M. gilvum PYR-GCK | Mflv_5091 | - | 0.0 | 48.79% (783) | triple helix repeat-containing collagen |
| M. leprae Br4923 | MLBr_01183 | - | 2e-11 | 35.87% (92) | hypothetical protein MLBr_01183 |
| M. abscessus ATCC 19977 | MAB_4284c | - | 7e-51 | 32.47% (542) | hypothetical protein MAB_4284c |
| M. marinum M | MMAR_0943 | - | 0.0 | 62.17% (1430) | PE-PGRS family protein |
| M. avium 104 | MAV_4827 | - | 2e-24 | 44.97% (169) | hypothetical protein MAV_4827 |
| M. smegmatis MC2 155 | MSMEG_0868 | - | 0.0 | 42.68% (1059) | hypothetical protein MSMEG_0868 |
| M. thermoresistible (build 8) | TH_3810 | - | 6e-46 | 38.12% (362) | PUTATIVE - |
| M. ulcerans Agy99 | MUL_4367 | - | 0.0 | 51.14% (1136) | PE-PGRS family protein |
| M. vanbaalenii PYR-1 | Mvan_1264 | - | 0.0 | 47.49% (817) | triple helix repeat-containing collagen |
CLUSTAL 2.0.9 multiple sequence alignment
Rv0578c|M.tuberculosis_H37Rv MSFVIATPEMLTTAATDLAKIGSTITAANTAAAAVAK-VLPASADEVSVA
Mb0593c|M.bovis_AF2122/97 MSFVIATPEMLTTAATDLAKIGSTITAANTAAAAVAK-VLPASADEVSVA
MMAR_0943|M.marinum_M MSFTVVEPQMLTAAAADLAKIGAAIDTVSTAAAASTTNLLPAAADEVSAA
TH_3810|M.thermoresistible__bu --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1264|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_0868|M.smegmatis_MC2_155 -----MHERLRERAGGVRKTLSDFAEGAGLKPSDTDDTRSPLRKPKFPAA
MUL_4367|M.ulcerans_Agy99 MSFVSVGPGLLEAAARDLAGLGAGLREANLAAAGATVGVLPAAGDEVSAA
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_4827|M.avium_104 --------------------------------------------------
Rv0578c|M.tuberculosis_H37Rv VAALFGTHAQEYQTVSAQVATFHDRFVQTLSAAASSYVAAEAVN------
Mb0593c|M.bovis_AF2122/97 VAALFGTHAQEYQTVSAQVATFHDRFVQTLSAAASSYVAAEAVN------
MMAR_0943|M.marinum_M IASLFGTHALAYQAIGAQAATFHDGFVQALSRAASRYAATEVAN------
TH_3810|M.thermoresistible__bu --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1264|M.vanbaalenii_PYR-1 ------------------------MMFLAPPGGPGPISAAIQLTSTGSEA
MSMEG_0868|M.smegmatis_MC2_155 LAPESPLPDLKPRWERPTTAPDSETPSITQPQGRDTAADPAEQQATSTNT
MUL_4367|M.ulcerans_Agy99 IAELFGGFGREYQAMGARVALLHDDFVRALTAGGSAYGQAEALNMWPLQE
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_4827|M.avium_104 --------------------------------------------------
Rv0578c|M.tuberculosis_H37Rv VEQSLLAAVNAPTQALFGRPLIGNGADGSPGTGQAGGPGGILYGNGGNGG
Mb0593c|M.bovis_AF2122/97 VEQSLLAAVNAPTQALFGRPLIGNGADGSPGTGQAGGPGGILYGNGGNGG
MMAR_0943|M.marinum_M VEQNLLGLINAPTQALFGRPLIGNGADGAAGTGQTGQAGGLLWGNGGAGG
TH_3810|M.thermoresistible__bu --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------MVTFGGG
Mvan_1264|M.vanbaalenii_PYR-1 TEP--------------------------------------WYVVSFGGS
MSMEG_0868|M.smegmatis_MC2_155 TDQPTSDSLGAQPTAQVARQVQAPATDPAPAAPSLRPISGLLSVVTLGTT
MUL_4367|M.ulcerans_Agy99 LEQQALGVVNAPSMALFGRPSIGNGVDGVAGTGQAGGAGGILWGNGGNGG
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_4827|M.avium_104 --------------------------------------------------
Rv0578c|M.tuberculosis_H37Rv SGAPGQRGGAGGAAGLIGNGGNGGAGGVGTTGGAG---------------
Mb0593c|M.bovis_AF2122/97 SGAPGQRGGAGGAAGLIGNGGNGGAGGVGTTGGAG---------------
MMAR_0943|M.marinum_M SGAPGQSGGTGGAAGFIGSGGSGGTGGLGAAGGAGGSAWLLGTGGTGGAG
TH_3810|M.thermoresistible__bu --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK ATPTP---------------------------------------------
Mvan_1264|M.vanbaalenii_PYR-1 GAPTP---------------------------------------------
MSMEG_0868|M.smegmatis_MC2_155 LIPNAPTEPADMPGVWAVMAWARRQPMYSDPAMRTT--------------
MUL_4367|M.ulcerans_Agy99 LGAAG---------------------------------------------
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_4827|M.avium_104 --------------------------------------------------
Rv0578c|M.tuberculosis_H37Rv ------------GHGGAGGWLYGNGGAGGFGGAGAVGGNGGAGGTAGLFG
Mb0593c|M.bovis_AF2122/97 ------------GHGGAGGWLYGNGGAGGFGGAGAVGGNGGAGGTAGLFG
MMAR_0943|M.marinum_M GWAAAGATGGIGGQGGAGGWLYGNGGIGGQGGAGALGGAGGSGGAARLFG
TH_3810|M.thermoresistible__bu --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK -------------------TSLGAAAVDLS--------------------
Mvan_1264|M.vanbaalenii_PYR-1 -------------------NNLAASLVDLS--------------------
MSMEG_0868|M.smegmatis_MC2_155 ----------VNPQAQLPVPTVASAVLDPTQIVNWLIYQPLHAAGQQFWV
MUL_4367|M.ulcerans_Agy99 ----------ANGGAGGSAGLIGTGGVGGAG------------------G
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_4827|M.avium_104 --------------------------------------------------
Rv0578c|M.tuberculosis_H37Rv VGGAGGAGGNGIAGVTGTSASTPGGSGTAGGAGGIGGNGGAGGAGGVLMG
Mb0593c|M.bovis_AF2122/97 VGGAGGAGGNGIAGVTGTSASTPGGSGTAGGAGGIGGNGGAGGAGGVLMG
MMAR_0943|M.marinum_M IGGAGGAGGHGVAGTAGTTASSAGVSGTDGGAGGIGGDGGAGGAGGLLIG
TH_3810|M.thermoresistible__bu --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK ----GTSCG----------LICNGQDG--------TGQN-----GGILFG
Mvan_1264|M.vanbaalenii_PYR-1 ----GTSCG----------LICNGQDG--------TGQN-----GGILFG
MSMEG_0868|M.smegmatis_MC2_155 VSPIGSTLGGVINTISGQYLIGNGING--------TADNPNGGTGGLLFG
MUL_4367|M.ulcerans_Agy99 VGAAGMTGGSGGAGGGGGWLWGAGGSGGA------AGAGGSGGSGGWLWG
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 -------------------------------------MSIIDFILNLFRD
MAV_4827|M.avium_104 --------------------------------------------MNIVLG
Rv0578c|M.tuberculosis_H37Rv NGGNGGAGGEGGPGGAGGAGASGAHATNLGADGQAGGNGGNGGAGGTGGV
Mb0593c|M.bovis_AF2122/97 NGGNGGAGGEGGPGGAGGAGASGAHATNLGADGQAGGNGGNGGAGGTGGV
MMAR_0943|M.marinum_M NGGAGGAGGLGGLGGVGGAGATGADAANPTTTGQAGGDGGNGGAGGAGGD
TH_3810|M.thermoresistible__bu -------------------------------------------------V
Mflv_5091|M.gilvum_PYR-GCK NGGSGWNSDVVGMDGGNGG--------------NGGLFGGNGGNGGNGLG
Mvan_1264|M.vanbaalenii_PYR-1 NGGSGWNSEIAGVSGGNGG--------------NAGLFGGNGGNGGNGLG
MSMEG_0868|M.smegmatis_MC2_155 DGGHGYDGSAAGLAGGNGG--------------NAGLFG-NGGNGGVGWA
MUL_4367|M.ulcerans_Agy99 NAGQTAGAGVGGAGGAGGAGDAGDQGVSGVAPGEAGAVGFAGGAGGAGGA
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 PVEAASYVADPEAALANAG--------------LSAVSAAQVGAVMPVVA
MAV_4827|M.avium_104 VSMAPSSIQMVVLEGEYADGATVEEDAIDVTGADDAATASAPDRVISAIL
Rv0578c|M.tuberculosis_H37Rv GGPGGGHGLLGLGGSHGAGGAGGSGGDGGAPGDGGNGATGTWGHNLGAGG
Mb0593c|M.bovis_AF2122/97 GGPGGGHGLLGLGGSHGAGGAGGSGGDGGAPGDGGNGATGTWGHNLGAGG
MMAR_0943|M.marinum_M GGGGGKSGWLGLAGALGGGGTGGSGGAGGAAGDGGDGATGVSG---GDGS
TH_3810|M.thermoresistible__bu DGDGGSGGRTGLFSKLSRGGDGGDGGLG---------------------G
Mflv_5091|M.gilvum_PYR-GCK GGNGGNGGNAGAFALFGNGGNGGNGGVGVVGATGAVG----------APG
Mvan_1264|M.vanbaalenii_PYR-1 SGDGGNGGDAGLFSLFGRGGNGGNGGVGIAGATGAVG----------APG
MSMEG_0868|M.smegmatis_MC2_155 GLDGGNGGSGG--LLMGIGGAGGAGGVGADGTSAHVDGG--------TGG
MUL_4367|M.ulcerans_Agy99 GGNGVGGGVNGAGGAGGAGGVGGGGGAGASGVGAGVAGG--------DGG
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 ESVASNYGYQSQWVNTGNPIHDLSGNLQNYYAAQPDG------------P
MAV_4827|M.avium_104 GTREGAADAGLQLSSIGVTWTDQLEAAALRDALAARR----------IDN
Rv0578c|M.tuberculosis_H37Rv TGGNGGNPGAGGAGGAGGASVGGSAHGANGAPGTTSTSGGNGGDGGKG--
Mb0593c|M.bovis_AF2122/97 TGGNGGNPGAGGAGGAGGASVGGSAHGANGAPGTTSTSGGNGGDGGKG--
MMAR_0943|M.marinum_M SGGNGGNPGVGGAGGAGGTGAGG-ARAADGATGNSPTSGGNGGNGGAG--
TH_3810|M.thermoresistible__bu NGGHGG--GTGIIS--------------------LLSLAGNGGNGG----
Mflv_5091|M.gilvum_PYR-GCK VAGATG--ATGVTSGVVGGNGEDAVGYGATGAAGAAGAAGAAGAAG----
Mvan_1264|M.vanbaalenii_PYR-1 VAGATG--ATGVTSNVTGGNGADAVGYGATGAAGAAGAAGAAGKAG----
MSMEG_0868|M.smegmatis_MC2_155 TGGTGG--GTGGTGGIGGTGGGLFGLLGHSGSTGAAGAAGNGGDGGNGGF
MUL_4367|M.ulcerans_Agy99 TGGAGG--AAGVGGAAGTGGTGGAAGVAGTGGDGGDGGAGGAGSDAS---
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 SILSPSLLSPRDNDFLSHNDTDFASHNPIASGNQVMSPSGNVDSFNRG--
MAV_4827|M.avium_104 VMLVSAFLAAAALAQNVGGAMGYERTAVLLVEPDTATLAVVETSDGS---
Rv0578c|M.tuberculosis_H37Rv --------ADAISSGQTGANGGRGGDGGQVGNGGAGGAGGRGGAGGLGFG
Mb0593c|M.bovis_AF2122/97 --------ADAISSGQTGANGGRGGDGGQVGNGGAGGAGGRGGAGGLGFG
MMAR_0943|M.marinum_M --------ADAIGSGQSGGAGGAGGNGGRVGNGGNGGAGGNGFLGAPAFS
TH_3810|M.thermoresistible__bu -----------NGYRTTDNNALDGGHGG----------------------
Mflv_5091|M.gilvum_PYR-GCK ----------AVGSAGAAGEAGETGTWG--NAGLPGKAGDAGGAG-----
Mvan_1264|M.vanbaalenii_PYR-1 ----------AVGSAGTAGSAGAPGVWG--NAGLPGAAGAAGGAG-----
MSMEG_0868|M.smegmatis_MC2_155 GYVLIAGPNVTVGSETRGGTGGAGGTGGQSTAAGPGKGGGGGGGGGGAIL
MUL_4367|M.ulcerans_Agy99 ---------LAGQAGFAGGSGGAGGVGGSAGAGGVNGSGGDGGAG-----
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 -----PLLDLSFGDLQFGNRDTTAIGDGAVAVGGSNSGPIASGQG-----
MAV_4827|M.avium_104 ---------IPDVYKQQIRAESYGDAAGQLSAMVAGLEKLESLPGG----
Rv0578c|M.tuberculosis_H37Rv SEAPGRPGGAGGTGGAGGNG--GTQAGDGGTGGAGGAGGDGGSGGAGSIG
Mb0593c|M.bovis_AF2122/97 SEAPGRPGGAGGTGGAGGNG--GTQAGDGGTGGAGGAGGDGGSGGAGSIG
MMAR_0943|M.marinum_M SN-PGGNGGNGGAGGAGGNG--GIQAGNGGDGGAGGHGGAGATGGSGTNG
TH_3810|M.thermoresistible__bu --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK -----------AVGAAGAAG------TVGTAGATGGTG------------
Mvan_1264|M.vanbaalenii_PYR-1 -----------AIGTAGVAG------AAGTAGATGGTG------------
MSMEG_0868|M.smegmatis_MC2_155 IGANGGTVDGHAIGGNGGNGGNGSTTAAGGNGGTGGTGRVIAEGTGSTA-
MUL_4367|M.ulcerans_Agy99 -----------AAGGAGGAS--ATVAGSGGVGGDGGAGG-----------
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_4827|M.avium_104 --------------------------------------------------
Rv0578c|M.tuberculosis_H37Rv FNASAPGAAGSPGGNGGNGGPGGAGGEGGAGG---------LALAASGQN
Mb0593c|M.bovis_AF2122/97 FNASAPGAAGSPGGNGGNGGPGGAGGEGGAGG---------LALAASGQN
MMAR_0943|M.marinum_M FDGAFSGADGSPGGNGGKGGTGGAGGNGGAAG---------LALAATGHD
TH_3810|M.thermoresistible__bu -----------NGGNVGFFSLFNLGG--------------------AGGW
Mflv_5091|M.gilvum_PYR-GCK -----------TGANGGAGGVGGVGGTGAAG--------------AAGGA
Mvan_1264|M.vanbaalenii_PYR-1 -----------VGGNGGAGQAGGIGGTGAAG--------------AAGQA
MSMEG_0868|M.smegmatis_MC2_155 -------EGTATGGDGGHSTGTGIGGNGGIGSVYAYGNNGAVSGTATGGR
MUL_4367|M.ulcerans_Agy99 ----------AAGGGVGAASLGGDGGHAGAG--------------GAGGE
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 --------STAVNGDVRDSNIINADHGSNVG-------------VDQSQT
MAV_4827|M.avium_104 --------LLLVGSGVDVAPLKQVLQTTTFLD-------------VSVAE
Rv0578c|M.tuberculosis_H37Rv GSQGAGGDGGAGGNGGTPGNGGHGAAGALGVNGGVGGAGGHGGDPGVGGA
Mb0593c|M.bovis_AF2122/97 GSQGAGGDGGAGGNGGTPGNGGHGAAGALGVNGGVGGAGGHGGDPGVGGA
MMAR_0943|M.marinum_M GGHGTGGAGGNGGAGGSAGNGGNGAKGVSGVNNGAGGNGGDGGTPGIGGT
TH_3810|M.thermoresistible__bu GGSG--VDG-------------------------VDVVGGNP--------
Mflv_5091|M.gilvum_PYR-GCK GGLG--ETGTTGGAGGVGGQ------GTAGGTGGVGGIGGAGSTGAVGGV
Mvan_1264|M.vanbaalenii_PYR-1 GTAG--ETGVTGGVGGIGGQ------GTEGGTGGVGGVGGVGATGGAGGV
MSMEG_0868|M.smegmatis_MC2_155 GGDG--IDGGTGGAGGMGEIYS----GADGEATGISAGGDGGSATGADSL
MUL_4367|M.ulcerans_Agy99 GLSGGFNTGAAGGIGGAGGAG-----GTGGDSGGVGGVNGDGGAGGGGGR
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 RVGGDYTNVSGHGSADIDKSVTVVDDHSQRNTTNINDSFNTDRSTNIGSG
MAV_4827|M.avium_104 EPETALARGAALAAANAPLFASSTAALAYAQDPGTGAVDQYSLPDYLYVP
Rv0578c|M.tuberculosis_H37Rv GGQGGS--GSTPGANG----------APGNTPTSGGNGGNGGRGADATGF
Mb0593c|M.bovis_AF2122/97 GGQGGS--GSTPGANG----------APGNTPTSGGNGGNGGRGADATGF
MMAR_0943|M.marinum_M GGAGGDSGGGSHGATG----------SDGATPHSGGNGGKGGDGADATGF
TH_3810|M.thermoresistible__bu ------------------------------------DGGTPG--------
Mflv_5091|M.gilvum_PYR-GCK GGKG------IQGGQG-------------LQGGKGGDGGAGGKGGDADSM
Mvan_1264|M.vanbaalenii_PYR-1 GGKG------IQGGQG-------------LQGGQGGDGGTGGTGGDATSM
MSMEG_0868|M.smegmatis_MC2_155 GGRGGT--SWVQAGYGPTTGGKASGTAKAGHGGKASDGGKGGNGGDALVM
MUL_4367|M.ulcerans_Agy99 GGDGGS--STSTSGVG-------------GAGGAGGNGGNAGFGVSAGGT
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 NTTNTEIGSHNQANIG----------------TSTSAGGSAAVGGNAGLA
MAV_4827|M.avium_104 VDPEPGDDELAYSAVG------------------EEDAESPTVVIEKLFL
Rv0578c|M.tuberculosis_H37Rv GQ------------------TGASGGRGGDGGLVGNGGAGG---------
Mb0593c|M.bovis_AF2122/97 GQ------------------TGASGGRGGDGGLVGNGGAGG---------
MMAR_0943|M.marinum_M GQ------------------TGGNGGRGGNGGLVGNGGDGG---------
TH_3810|M.thermoresistible__bu ----------------------AHGESHTPGVYTDRQ-------------
Mflv_5091|M.gilvum_PYR-GCK GS------------------AGATGGKGGNGGNGGRGGLFG---------
Mvan_1264|M.vanbaalenii_PYR-1 GE------------------AGATGGKGGNGGNGGRGSLFG---------
MSMEG_0868|M.smegmatis_MC2_155 AAGATGVATGNTAIGGNGGAASANGAVGGNGGFTNIAAIHGSITDSSATS
MUL_4367|M.ulcerans_Agy99 GG-----------------SAGDGGAGGGAGGVDGVGGASG---------
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 GN----------------------AGLAGNAGLAGNAGLAG---------
MAV_4827|M.avium_104 PE--------------------DSEPRRRPVLLVG---------------
Rv0578c|M.tuberculosis_H37Rv ------AGGNGSKGLPGLG-----------RLGNPGLDGGTGGNGGAGGS
Mb0593c|M.bovis_AF2122/97 ------AGGNGSKGLPGLG-----------RLGNPGLDGGTGGNGGAGGS
MMAR_0943|M.marinum_M ------TGGAGGTGLGGLTNSFP------GSSGTGGDPGGTGGNGGAGGS
TH_3810|M.thermoresistible__bu ------------------------------------------GEDGEDGT
Mflv_5091|M.gilvum_PYR-GCK ------KGGNAGNGAD----------------------GGTGGAGGAGGT
Mvan_1264|M.vanbaalenii_PYR-1 ------RGGNAGNGGN----------------------GGTGGNGGNGGT
MSMEG_0868|M.smegmatis_MC2_155 GHGGAAQGGNGGNGGNGWVQAYDPNGPAGTTIDKGKAAGGNGGDGGFNGT
MUL_4367|M.ulcerans_Agy99 ------NGGAAGAGGAG---------------GSGIGAGIDGGAGGAGGT
MLBr_01183|M.leprae_Br4923 -----------------------------------------MPLFLNAEP
MAB_4284c|M.abscessus_ATCC_199 -------------------------------------NAGLAGNAGLAGN
MAV_4827|M.avium_104 -----------------------------------------SGLAVVGIS
Rv0578c|M.tuberculosis_H37Rv GGAWAGNGGTGG-----------------AGGTGGVGGTGGSGSDGVNGS
Mb0593c|M.bovis_AF2122/97 GGAWAGNGGTGG-----------------AGGTGGVGGTGGSGSDGVNGS
MMAR_0943|M.marinum_M GGFFAGDGGNGG-----------------AGGVGGTGGDGGNGATGGTGA
TH_3810|M.thermoresistible__bu GTGIGGRGGNGG----------------SSSGTHPMAEDG--------EH
Mflv_5091|M.gilvum_PYR-GCK GG-TGGAGGTGG-----------------TGGTGGIGGAGSTGGTGGTGG
Mvan_1264|M.vanbaalenii_PYR-1 GG-TGGNGGTGG-----------------TGGTGGIGGAGSTGGTGGTGG
MSMEG_0868|M.smegmatis_MC2_155 GGATGGRGGDGAGASVWKANGQHSTGQTDTGGNGGRGGDGGTFVNAGANG
MUL_4367|M.ulcerans_Agy99 GGAAGFPGGGGTTG------------AWGTGGAGGAGGAGGAGDHGGVGV
MLBr_01183|M.leprae_Br4923 QALTAAANTLEG-----------------LSAATVASNAAAAQLTTEIAP
MAB_4284c|M.abscessus_ATCC_199 AGLAGNAGLAGNAG---------------LAGNAGLAGNAGLAGNAGLAG
MAV_4827|M.avium_104 AVLALEIALAIGIR---------------TTGTVALQPTPNQHLIVPTEQ
.
Rv0578c|M.tuberculosis_H37Rv SAGADGHPGGTGGVGGTGGKGGDGGDGGAAPNGVAGSQGPGGAGGDGGTG
Mb0593c|M.bovis_AF2122/97 SAGADGHPGGTGGVGGTGGKGGDGGDGGAAPNGVAGSQGPGGAGGDGGTG
MMAR_0943|M.marinum_M TAGANGQDGGNGGTGGTGGQGGAGGAGGATFTGKAGTQGAGGAGGDGGAG
TH_3810|M.thermoresistible__bu VKALDGRPGLD---GGNGSHG--------------------GNGGHGGRG
Mflv_5091|M.gilvum_PYR-GCK TGGTGGTGGTG-GTGGTGGTG--------------------GTGGKGGTG
Mvan_1264|M.vanbaalenii_PYR-1 TGGTGGTGGTG-GTGGTGGTG--------------------GTGGKGGTG
MSMEG_0868|M.smegmatis_MC2_155 NGGAGGAGGVSEGEGGTGGHG--------------------GDGGRGGDG
MUL_4367|M.ulcerans_Agy99 NPGDSGTAGWAGGAGGAGGAGGS-----------AAFNGVNGAGGAGGNG
MLBr_01183|M.leprae_Br4923 PAADDVSILLAHFFSGHGRQY----------------------QAHASQG
MAB_4284c|M.abscessus_ATCC_199 NAGLAGNAGLAGNAGLAGNAG------------------LAGNAGLAGNA
MAV_4827|M.avium_104 APAPPPVQASAPQPKISVPEP--------------------VAAPKPLSP
.
Rv0578c|M.tuberculosis_H37Rv GVGGNGGRGIDGADGATAG--ARGQDGGAGGAGGKGGRGGTGGPGGAG-P
Mb0593c|M.bovis_AF2122/97 GVGGNGGRGIDGADGATAG--ARGQDGGAGGAGGKGGRGGTGGPGGAG-P
MMAR_0943|M.marinum_M GNAGNGGSGATGADGATVGTGVDGQDGGNGGAGGTGGQGGAGGDGGAGST
TH_3810|M.thermoresistible__bu GFLGIGGSG---------------------------GWGGHGGNGGD---
Mflv_5091|M.gilvum_PYR-GCK GTGGAGGTG------------------------GDGGTGGTGGTGGTG--
Mvan_1264|M.vanbaalenii_PYR-1 GTGGDGGTG------------------------GTGGTGGTGGTGGTG--
MSMEG_0868|M.smegmatis_MC2_155 ALGGNGGTGGV--------------------GLGNGGKGGNGGNGGNGGT
MUL_4367|M.ulcerans_Agy99 GAGGGGGAGAS--------------------GIGAGVAGGDGGTGGTGGA
MLBr_01183|M.leprae_Br4923 ATNHQDLIQS--------------------------LLTSSSAYAGT---
MAB_4284c|M.abscessus_ATCC_199 GLAGNAGLAGN------------------------AGLAGNAGLAGNAAV
MAV_4827|M.avium_104 PVAAPLPAAPP---------------------PAAPPLPEAPPIPAAPPV
.
Rv0578c|M.tuberculosis_H37Rv AGTTGSQGAGGNGGSGGTGG---------DPGDGGNGANGSVFTNNG-IG
Mb0593c|M.bovis_AF2122/97 AGTTGSQGAGGNGGSGGTGG---------DPGDGGNGANGSVFTNNG-IG
MMAR_0943|M.marinum_M TGNQGGGGAGGNGGGGGAGG---------NGGSGANGADGSISGLGGQAG
TH_3810|M.thermoresistible__bu --------TDADGGNGGDG---------------GNGGSAG---------
Mflv_5091|M.gilvum_PYR-GCK -------GTGGTGGTGGAG-----------DGTGGTGGTGG----TGGQG
Mvan_1264|M.vanbaalenii_PYR-1 -------GTGGTGGTGGAG-----------DGLGGTGGTGG----TGGFG
MSMEG_0868|M.smegmatis_MC2_155 YVDPSHTGAGGNGGNGGAGRIRVNNGTATGTATGGNGGNGGNGDADGHRG
MUL_4367|M.ulcerans_Agy99 AGTGGAAGTGGTGGAAGAAG---------SAGDGGAGGAGG-AGDDGSAG
MLBr_01183|M.leprae_Br4923 ----------ETANHDSL--------------------------------
MAB_4284c|M.abscessus_ATCC_199 AGNAAVAGNAAVAGNAAVGG---------VLNTGVSGAIGG---------
MAV_4827|M.avium_104 VPVPVVVPPVPVPVPVRIPVP---------DPVSPPQLLAP---------
Rv0578c|M.tuberculosis_H37Rv GNGGNGG-----------NAGPSGAGGSGGAGSTFGATGSSSSIHVN---
Mb0593c|M.bovis_AF2122/97 GNGGNGG-----------NAGPSGAGGSGGAGSTFGATGSSSSIHVN---
MMAR_0943|M.marinum_M GNGGDGG-----------DAGVGGSGGDGGAGLSVGAHGATGNVVAN---
TH_3810|M.thermoresistible__bu ------------------------RGGTGGLRGVFGINGGNG--------
Mflv_5091|M.gilvum_PYR-GCK GQGGQGG-----------------TGGTGGQGG-LGGGGGTG--------
Mvan_1264|M.vanbaalenii_PYR-1 GQGGQGG-----------------TGGTGGQGG-LGGVGGTG--------
MSMEG_0868|M.smegmatis_MC2_155 GKGGDGGEALIRATVIGSNASGTATGGDGGNGGTLGATNGTGGAATIVAY
MUL_4367|M.ulcerans_Agy99 VVSGDPG-----------------TAGKAGGAGGAGGVGGNGVAG-----
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 -----------------------SSHVGGAINESLGGSGSVG--------
MAV_4827|M.avium_104 ----------------------PRLSVPQPVQPPVRVPQPPSPPQ-----
Rv0578c|M.tuberculosis_H37Rv --------------GGNGGNGGNGDHALSGN--GAAGGNGGNGGNG--SL
Mb0593c|M.bovis_AF2122/97 --------------GGNGGNGGNGDHALSGN--GAAGGNGGNGGNG--SL
MMAR_0943|M.marinum_M --------------GGNGGQGGNGGNALIGTSDGGAGGAGGAGGKA--WL
TH_3810|M.thermoresistible__bu ----------------RAGLGGRGX-------XXXGGGVG----------
Mflv_5091|M.gilvum_PYR-GCK ---------------GQGGTGGTGG-------QGGTGGTGGTGGTG----
Mvan_1264|M.vanbaalenii_PYR-1 ---------------GTGGTGGTGG-------QGGTGGTGGTGGTG----
MSMEG_0868|M.smegmatis_MC2_155 NVVQANPQASGTATDGHGGSGINGG-------HGGNGGQGTIEANGPSAV
MUL_4367|M.ulcerans_Agy99 ---------------GVNGSGGAGG-------AGGAGGTGGAGASG----
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 ------------------GSTAVGG--------GAHTGVGGGVSTG----
MAV_4827|M.avium_104 ----------------VGGTVPQSPPQ-----HQTPPGEGTPPKPD----
Rv0578c|M.tuberculosis_H37Rv RGSGGAGGHGGNGGN-----------------------------------
Mb0593c|M.bovis_AF2122/97 RGSGGAGGHGGNGGN-----------------------------------
MMAR_0943|M.marinum_M MGDGGSGGHGGNGGAGGSSPQGSGGGGGNGGAGGTGGDAGLQEGGGGTGG
TH_3810|M.thermoresistible__bu -----AAVRSGNGVFS----------------------------------
Mflv_5091|M.gilvum_PYR-GCK ----GTGGAGGDGGLG----------------------------------
Mvan_1264|M.vanbaalenii_PYR-1 ----GTGGAGGDGGLG----------------------------------
MSMEG_0868|M.smegmatis_MC2_155 ASGIGAGGNGGDGIDG----------------------------------
MUL_4367|M.ulcerans_Agy99 ---VPASVDGGDGGAG----------------------------------
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 ---VGVGSHVGGGISES---------------------------------
MAV_4827|M.avium_104 ----GPGNYGGGHVPTP---------------------------------
Rv0578c|M.tuberculosis_H37Rv ---------------ASRGMGGDGG-------------------------
Mb0593c|M.bovis_AF2122/97 ---------------ASRGMGGDGG-------------------------
MMAR_0943|M.marinum_M NGGNGGAGGTGKASSATGGIGGGGGNGGAAGQVGDGGGGGTGGNGGNGGA
TH_3810|M.thermoresistible__bu ------------------GGGGTPS-------------------------
Mflv_5091|M.gilvum_PYR-GCK ------------------GLGGFGG-------------------------
Mvan_1264|M.vanbaalenii_PYR-1 ------------------GLGGFGG-------------------------
MSMEG_0868|M.smegmatis_MC2_155 ------------------GLGGNGG-------------------------
MUL_4367|M.ulcerans_Agy99 ------------------GAGGAAG-------------------------
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 -------------------LGGSGS-------------------------
MAV_4827|M.avium_104 ------------------GAGGSGG-------------------------
Rv0578c|M.tuberculosis_H37Rv --------TGGAGGNAGQIGNGGAGGNGGDGGTGSDGNPGAITGSGG---
Mb0593c|M.bovis_AF2122/97 --------TGGAGGNAGQIGNGGAGGNGGDGGTGSDGNPGAITGSGG---
MMAR_0943|M.marinum_M GRDGAMGGTGGIGGDAGMVGNGGGGGTGGNGGNGGNGNAGGGPGIGG---
TH_3810|M.thermoresistible__bu --------AGFGVPTTIQFPAGSCTSRAVSREG-----------------
Mflv_5091|M.gilvum_PYR-GCK --------SGGTGGQGGLGGPGGSTGGAGGAGG--QAGTAGKGGLFG---
Mvan_1264|M.vanbaalenii_PYR-1 --------VGGTGGQGGQGGPGGSTGGAGGAGG--QAGVAGKGGLFG---
MSMEG_0868|M.smegmatis_MC2_155 --------DGVVNTTANAANPGSATGTATGGDGGKATGTASQGGNGGPSW
MUL_4367|M.ulcerans_Agy99 --------TGGSGGSAGNTGAGGAGGAGGAGGSAASTGVNGDGGAGG---
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 --------VGGSTAVGGGAHTGVGGGVSTGVGVGSHVGGGISESLGG---
MAV_4827|M.avium_104 ------------SGGGHVPTPGAGGSGGSGGGHVPTPGTGGPGGTGG---
Rv0578c|M.tuberculosis_H37Rv -RGGDGGVGGQGGSVAGDGADGGRGGAGGTGGTGLRGTTGATGATGTFDA
Mb0593c|M.bovis_AF2122/97 -RGGDGGVGGQGGSVAGDGADGGRGGAGGTGGTGLRGTTGATGATGTFDA
MMAR_0943|M.marinum_M -NGAEGGAGGSGGSSSGNGGAGGKGGSGGTGGAGQFGNTGGNGANGTFDN
TH_3810|M.thermoresistible__bu -------IMPSSRAASARAG---------------------------AAC
Mflv_5091|M.gilvum_PYR-GCK -GSGSAGKAGATGAAGASGGKGAQGATGAQGATG------AQGATG-ATG
Mvan_1264|M.vanbaalenii_PYR-1 -GSGSAGTAGVTGASGASGGKGAQGATGAQGATG------AQGATG-ATG
MSMEG_0868|M.smegmatis_MC2_155 VQSGYGSTLGGNATGTATAGKGGEASNGGVAGNGGNALVMAAGTTGVATG
MUL_4367|M.ulcerans_Agy99 -AGGVGGLGGDSAATAGGGGAGGDGGKGGAGGAG----VNGVGGGDGGKG
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 -----SGSVGGSTAVGGGAHTGVGGGVNTGVGVG-------------SHV
MAV_4827|M.avium_104 --------SGGGHVPTPGAGTPGGSGGGHLPFPG---------------A
Rv0578c|M.tuberculosis_H37Rv GADGHGGNGGTGGVGGTGGAGGGGGNGGAGGKALSPTGNNGSQGAGGDGG
Mb0593c|M.bovis_AF2122/97 GADGHGGNGGTGGVGGTGGAGGGGGNGGAGGKALSPTGNNGSQGAGGDGG
MMAR_0943|M.marinum_M GGDGRGGAGGTGGTGGTGGDGGVGGNGGAGGKAISPTGQDGAQGAGGNGG
TH_3810|M.thermoresistible__bu ASSTSRSRRSFCCSRA----------------------------------
Mflv_5091|M.gilvum_PYR-GCK AAGKAGATGAAGAAGAAGSAG-----------TTGAQGSAG-TNGA-NGA
Mvan_1264|M.vanbaalenii_PYR-1 ASGAQGSAGSAGSAGVAGSAG-----------TTGAQGSAG-TNGA-NGA
MSMEG_0868|M.smegmatis_MC2_155 NTATGGDGGAATTAGATGGAGGFSNIAAIHGAITDSTAISG-HGGAGNGG
MUL_4367|M.ulcerans_Agy99 GTGGAGGAGGAGSDGIIPSNGGLGGNGGNGGNGGQAFGDGV-GGAGGIGG
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 GGGISESLGGSGSVGGSTAVG------------------GGAHTSAINDA
MAV_4827|M.avium_104 GSTPGGSGGGHLPTPGAGTPG-----------------------------
Rv0578c|M.tuberculosis_H37Rv AGGAGGTGGTGGDGGRGAHGTLFSSLAGTGGTGGNGGTGGTG-GTGGAGG
Mb0593c|M.bovis_AF2122/97 AGGTGGTGGTGGDGGRGAHGTLFSSLAGTGGTGGNGGTGGTG-GTGGAGG
MMAR_0943|M.marinum_M AGGTGGNGGFGGSGGSGADGTLFSSLAGTGGTGGNGGTGGDG-GAGGAGG
TH_3810|M.thermoresistible__bu --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK NGSQGAAGKAGATGTTGATG--------AAGEDGDAGSGGSG-INGGAGG
Mvan_1264|M.vanbaalenii_PYR-1 NGSQGAAGKAGATGTTGATG--------AAGDAGDPGSEAVD-INGGAGG
MSMEG_0868|M.smegmatis_MC2_155 NGGKGADGWVQAYDPAGPVGSKIANSSAVAGNGGDGGVNGTGGASGGDGG
MUL_4367|M.ulcerans_Agy99 KGGNAAIGTIVINGGVGGAGG-----SGGLGGATEDGVGGVG-CAGGAGG
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 LGGSGSVGGSTAVGGGAHTSAINESMNSSINASHSSSMNESFGSSMGSHG
MAV_4827|M.avium_104 -GGLGGFGGGHAPAPGGGLG------------------GGGGHAPAPGGG
Rv0578c|M.tuberculosis_H37Rv AGGTGSTLGATGATGAAGRAGNGGVGGSGGLGSAFGPGGTGGMGGAGGTS
Mb0593c|M.bovis_AF2122/97 AGGTGSTLGATGATGAAGRAGNGGVGGSGGLGSAFGPGGTGGMGGAGGTS
MMAR_0943|M.marinum_M APGTGLIPGSTGAAGATGRAGTGGFGGNGGLGSAFGPGGTGGNGGSGGSS
TH_3810|M.thermoresistible__bu --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK AGG------------------------------AGGEGGEGGDGGKGGAG
Mvan_1264|M.vanbaalenii_PYR-1 AGG------------------------------AGGEGGEGGAGGAGGDG
MSMEG_0868|M.smegmatis_MC2_155 NGGNTSVWKSGGQT-------------------ADGEHNTGGNGGNGGDG
MUL_4367|M.ulcerans_Agy99 NGGRGDMLFTVGGS-------------------GGTGGDGGGGGSASGSG
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 AAGTG----------------------------FEAQGHAQGHASETAHT
MAV_4827|M.avium_104 LGG------------------------------FGGGHSGGGLGGLGGGH
Rv0578c|M.tuberculosis_H37Rv TVSAGGDGGRGGFGGDGLDASSGGNGGDGGHGGDGFRTAGAGGRGGDGGK
Mb0593c|M.bovis_AF2122/97 TVSAGGDGGRGGFGGDGLDASSGGNGGDGGHGGDGFRTAGAGGRGGDGGK
MMAR_0943|M.marinum_M STSAGGGGGTGGAGGTGFDGSAGGAGGNGGQGGDGLGTAGDGGNGGTGGK
TH_3810|M.thermoresistible__bu --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK AE--------GGAGGGG-----GAGGSGAG-------GAG--GAGGSGGS
Mvan_1264|M.vanbaalenii_PYR-1 SE--------GGAGGSG-----GAGGSGTG-------GAG--GAGGSGGS
MSMEG_0868|M.smegmatis_MC2_155 SEPGPGGNGAGGAGGNG-----GTGGTTAG-------GSGNGGNGGNGGN
MUL_4367|M.ulcerans_Agy99 TGGSGGTGGVGGIGGDGKLGGFGGDGGDGG-------DGGFGVIGGQGGG
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 TLPGAEHH------------------------------------------
MAV_4827|M.avium_104 K-------------------------------------------------
Rv0578c|M.tuberculosis_H37Rv GADPGGLFPIPGAGGKGGTGGTGGTAHLGPLAIIGQSGQPGQFGSPGADG
Mb0593c|M.bovis_AF2122/97 GADPGGLFPIPGAGGKGGTGGTGGTAHLGPLAIIGQSGQPGQFGSPGADG
MMAR_0943|M.marinum_M GSNAPIGFSFGGAGGKGGTGGTGGTAHLGPLAIHGQSGDPGQSGPPVVDG
TH_3810|M.thermoresistible__bu --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK G----------GSGGSGGSGGAAGDSDD----------------------
Mvan_1264|M.vanbaalenii_PYR-1 G----------GSGGAGGSGGAAGDSD-----------------------
MSMEG_0868|M.smegmatis_MC2_155 G----------GADGTPGTAGTTGANNP----------------------
MUL_4367|M.ulcerans_Agy99 G----------GFGGLGGTGAGGAPSDKGINGEPGNPG------------
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_4827|M.avium_104 --------------------------------------------------
Rv0578c|M.tuberculosis_H37Rv RGGAGGAGGGGGAGGSF
Mb0593c|M.bovis_AF2122/97 RGGAGGAGGGGGAGGSF
MMAR_0943|M.marinum_M NGGAGGQGGPGGAGGSF
TH_3810|M.thermoresistible__bu -----------------
Mflv_5091|M.gilvum_PYR-GCK -----------------
Mvan_1264|M.vanbaalenii_PYR-1 -----------------
MSMEG_0868|M.smegmatis_MC2_155 -----------------
MUL_4367|M.ulcerans_Agy99 -----------------
MLBr_01183|M.leprae_Br4923 -----------------
MAB_4284c|M.abscessus_ATCC_199 -----------------
MAV_4827|M.avium_104 -----------------