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RIGRREGLAVAIGFVLVGAAFVLPRLNLGIKPRSDIGLERFATRAGAAPIFGYWDAHVGWGTAPAVLTAV AVVAWGPVVAHRLPWRVLTLSTWATAAAWAFSLAMIDGWQRGFAGRLTTRDEYLWQVPGIADIPATLRTF TSRILDFQPNSWVTHVSGHPPGALLTFVWLDRIGLRGGGWAGLVCLLVGSSAAAAVLIAVRVLASEQMAR RTAPFVAVAPTAIWIAVSADGYFAGVAAWGIALLAVAVHGATRFPALVAAGAGLLLGWGVFLNYGLVLIV LPGMAVLAAADWRPVLRALGPAVLAALVVAVSFAVAGFSWFDGYTLVQQRYWQGIAKDRPFGYWSWANLA CVVCAIGLGSVAGLSRVFDRAAISRRSGCHLLLLAVLAAIALADLSMLSKAETERIWLPFTIWLTAAPAL LPPRSHRLWLAVNAAGALLLNSIIFTNW*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv0541c | - | - | 100% (449) | PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0555c | - | 0.0 | 99.78% (449) | integral membrane protein |
| M. gilvum PYR-GCK | - | - | - | - | - |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4441 | - | 4e-05 | 34.85% (132) | putative oxidoreductase |
| M. marinum M | MMAR_0887 | - | 0.0 | 77.56% (450) | hypothetical protein MMAR_0887 |
| M. avium 104 | MAV_4603 | - | 0.0 | 77.56% (450) | integral membrane protein |
| M. smegmatis MC2 155 | MSMEG_0999 | - | 1e-178 | 68.28% (454) | integral membrane protein |
| M. thermoresistible (build 8) | - | - | - | - | - |
| M. ulcerans Agy99 | MUL_0640 | - | 0.0 | 76.89% (450) | hypothetical protein MUL_0640 |
| M. vanbaalenii PYR-1 | Mvan_0891 | - | 1e-179 | 68.29% (451) | putative integral membrane protein |
CLUSTAL 2.0.9 multiple sequence alignment
Rv0541c|M.tuberculosis_H37Rv ------MRIGRREGLAVAIGFVLVGAAFVLPRLNLG-IKPRSDIGLERFA
Mb0555c|M.bovis_AF2122/97 ------MRIGRREGLAVAIGFVLVGAAFVLPRLNLG-IKPRSDIGLERFA
MMAR_0887|M.marinum_M ------MRIARRETAAVTVGVVLVAAAFVLPRLDLG-VKPRRDIGLERFA
MUL_0640|M.ulcerans_Agy99 ------MRIARRETAAVTVGVVLVAAAFVLPRLDLG-VKPRRDIGLERFA
MAV_4603|M.avium_104 --------------MAAAVGAALVAAAFLLPRLNLG-VRPRLDVGPERFA
MSMEG_0999|M.smegmatis_MC2_155 ------MQIGRRELVAVIIAILLVTAAFVVPHLDLGIVTPLINSTPAQIY
Mvan_0891|M.vanbaalenii_PYR-1 ------MPIGRKEAVAVAVGSVLVVAAFVIPHLDLGVVTPLINATPERLR
MAB_4441|M.abscessus_ATCC_1997 MEHAARRIIAGLIAAAAALAVGQLAAAAVAPDSAPFYAVGNTVVDHTPAA
*. :. : ** : *
Rv0541c|M.tuberculosis_H37Rv TRAGAAPIFGYWDAHVGWGTAPAVLTAVAVVA------------------
Mb0555c|M.bovis_AF2122/97 TRAGAAPIFGYWDAHVGWGTAPAVLTAVAVVA------------------
MMAR_0887|M.marinum_M SRAGAAPIFGYWDIHASWGTIAAILLALAVLV------------------
MUL_0640|M.ulcerans_Agy99 SRAGAAPIFGYWDIHASWGTIAAILLALAVLV------------------
MAV_4603|M.avium_104 THAGAAPIFGEWLIHAGWGTGPAVALAAAVVA------------------
MSMEG_0999|M.smegmatis_MC2_155 SFADTAPIFGWWNAHVGWGTVPAVLIGAATVW------------------
Mvan_0891|M.vanbaalenii_PYR-1 SFADTAPIFGWWNTHVGAGTIPAFAIGAAAVL------------------
MAB_4441|M.abscessus_ATCC_1997 VREWVIGIFGTSDKAVLFACLTVIIALLAALAGLVEGERRYGTVLIGLLG
. *** . . ... *.:
Rv0541c|M.tuberculosis_H37Rv -WGPVVAHRLPWRVLTLSTWATAAAWAFSLAMIDGWQRGFAGRLTTRDEY
Mb0555c|M.bovis_AF2122/97 -WGPVVAHRLPWRVLTLSTWATAAAWAFSLAMIDGWQRGFAGRLTTRDEY
MMAR_0887|M.marinum_M -WGPRVARKLSWRVLPLATWATACGWAFSLAMIDGFERGFAGRLTTKDEY
MUL_0640|M.ulcerans_Agy99 -WGPRVARKLSWRVLPLATWATACGWPFSLAMIDGFERGFAGRLTTKDEY
MAV_4603|M.avium_104 -WGPVLAQRLSWRALTLGSWAVAAGWAFALAMIDGWQRGFAGRLTTRDEY
MSMEG_0999|M.smegmatis_MC2_155 -WGPAVAQRLPWRALPLVAWVTSALWAFSLAMIDGWQRGFAGRLTARHEY
Mvan_0891|M.vanbaalenii_PYR-1 -WGPPLAQRLPWRWLPWLSWTVSCAWAFSLAMVDGWQRGFAGRLTARHEY
MAB_4441|M.abscessus_ATCC_1997 VFGAVAAVTRPAGTFAWIWPSVIAAVAGALVLGTLVHRAQSQAVPDRRRF
:*. * . :. . . . :*.: .*. : :. : .:
Rv0541c|M.tuberculosis_H37Rv LWQVPGIADIPATLRTFTSRILDFQPNSWVTHVSGHPPGALLTFVWLDRI
Mb0555c|M.bovis_AF2122/97 LWQVPGIADIPATLRTFTSRILDFQPNSWVTHVSGHPPGALLTFVWLDRI
MMAR_0887|M.marinum_M LSEVGGVTDIPVMLRTFASRIVDYQPNSWTTHVSGHPPGALLTFVWLDRI
MUL_0640|M.ulcerans_Agy99 LSEVGGVTDIPVMLRTFASRIVDYQPNSWTTHVSGHPPGALLTFVWLDRI
MAV_4603|M.avium_104 LWEVPRVTDIAAAVRTFSSRIVDYQPHSWTTHVSGHPPGALLTFVWLDRL
MSMEG_0999|M.smegmatis_MC2_155 LRQVPSVTDIGEALRTFSSRILDFQPDSWITHVSGHPPGALLTFVWLDRI
Mvan_0891|M.vanbaalenii_PYR-1 LRQVPTVTDIPEALRTFAGRILDYQPDSWITHVSGHPPGALLTFVWLDRI
MAB_4441|M.abscessus_ATCC_1997 FGTAAVFALGSAGLYWLGTRWSKGTVVAAERREATVPAPVAPAPPLPEGI
: . .: : : * . : : : *. . : : :
Rv0541c|M.tuberculosis_H37Rv GLRGGG---------WAGLVCLLVGSSAAAAVLIAVRVLASEQMARRTAP
Mb0555c|M.bovis_AF2122/97 GLRGGG---------WAGLVCLLVGSSAAAAVLIAVRVLASEQMARRTAP
MMAR_0887|M.marinum_M GLGGGA---------WAGFLCLLVGSSAAAAMVIAVGALAGEHVARRAAP
MUL_0640|M.ulcerans_Agy99 GLGGGA---------WAGFLCLLVGSSAAAAMVIAVGALAGKHVARRAAP
MAV_4603|M.avium_104 GLHGGG---------WAGLLCLLAGSSAAAAVLIGVRALADEPTARRAAP
MSMEG_0999|M.smegmatis_MC2_155 GLGGGA---------WAGLLCLLVGSSAAAAIVVALRAVSGEATARLAAP
Mvan_0891|M.vanbaalenii_PYR-1 GLGGGA---------WAGLLCLLAGSSIAAAIVVTVRALADEDTARAAAP
MAB_4441|M.abscessus_ATCC_1997 DVKGAVPYITSNTDFYRIDTALRVPQVSTAEWQLNIHGMVDRPRTLMWAD
.: *. : .* . . :* : : : .. : *
Rv0541c|M.tuberculosis_H37Rv FVAVAPTAIWIAVSADGYFAGVAAWGIALLAVAVHGATRFP---ALVAAG
Mb0555c|M.bovis_AF2122/97 FVAVAPTAIWVAVSADGYFAGVAAWGIALLAVAVHGATRFP---ALVAAG
MMAR_0887|M.marinum_M FVAIAPTAIWIAVSADGYFAGVTAWGITLLAIAVHGGSRFR---ALWAAG
MUL_0640|M.ulcerans_Agy99 FVAIAPTAIWIAVSADGYFAGVTAWGITLLAIAVHGGSRFR---ALWAAG
MAV_4603|M.avium_104 FVALAPTAIWVAVSADGYFAGVAAWGIALLAVAVHRPLRFP---ALTAAG
MSMEG_0999|M.smegmatis_MC2_155 FVAVAPTAIWIAVSADGYFAGVAAWGLALLALAVRDSVHRRRVALPTAVG
Mvan_0891|M.vanbaalenii_PYR-1 FVAVAPTAIWIAVSADGYFAGVAAWGITLLALAVRGSVRQP---VAAAIG
MAB_4441|M.abscessus_ATCC_1997 LNAMAATQRAVTLTCVSNEIGGNLIGNAVWTGFPIKPILES---VGVHPD
: *:*.* ::::. . * * :: : .
Rv0541c|M.tuberculosis_H37Rv AGLLLGWGVFLNYG---LVLIVLPGMAVLAAAD---------WRPVLRAL
Mb0555c|M.bovis_AF2122/97 AGLLLGWGVFLNYG---LVLIVLPGMAVLAAAD---------WRPVLRAL
MMAR_0887|M.marinum_M AGLVLGWAIFLSYG---LALMGLPALAVLASANH--------WRTALKAL
MUL_0640|M.ulcerans_Agy99 AGLVLGWAIFLSYG---LALMGLPALAVLASANH--------WRTALKAL
MAV_4603|M.avium_104 AGLLLGWGVFCNYG---LMLMGLPAAAVLAAAPRPPRDGWTQWRAVLRAL
MSMEG_0999|M.smegmatis_MC2_155 SGLLLGWGIFLNYG---LALAALIALAVLITAPD--------WRAALRVA
Mvan_0891|M.vanbaalenii_PYR-1 SGLLLGWAVFLNYG---LVLMAFPAVAVLLGAAT--------WQAAVRTL
MAB_4441|M.abscessus_ATCC_1997 ADMLLSKSVDGWTAGTPLQVLTDGRDAILAIAMN---------GTPLPVE
:.::*. .: . * : *:* * . : .
Rv0541c|M.tuberculosis_H37Rv GPAVLAALVVAVSFAVAGFSWFDGYTLVQQRYWQGIAKDRPFGYWSWANL
Mb0555c|M.bovis_AF2122/97 GPAVLAALVVAVSFAVAGFSWFDGYTLVQQRYWQGIAKDRPFGYWSWANL
MMAR_0887|M.marinum_M WPAVLAALGVALAFAVAGFWWFDGYTLVQQRYWQGIAHDRPFQYWSWANL
MUL_0640|M.ulcerans_Agy99 WPAVLAALGVALAFAVAGFWWFDGYTLVQQRYWQGIAHDRPFQYWSWANL
MAV_4603|M.avium_104 GPAALAAIAVAVAFAVAGFYWFDGYTLVQQRYWQGIAKDRPFQYWSWANL
MSMEG_0999|M.smegmatis_MC2_155 VPAVIAVLAVVAVFLVAGFWWFDGYTLVQERYWQGIANNRPFQYWSWANL
Mvan_0891|M.vanbaalenii_PYR-1 VPAVVAALAVVAVFAAAGFWWFDGYLLVQERYWQGIANDRPFQYWGWANF
MAB_4441|M.abscessus_ATCC_1997 HGYPVRQVVPGLYGYVSATKWVVDWEITRFDKADAYWTIRGWSARGPIKT
: : .:. *. .: :.: :. * : . :
Rv0541c|M.tuberculosis_H37Rv ACVVCAIGLGSVAGLS-RVFDRAAISRRSGCHLLLLAVLAAIALADLSML
Mb0555c|M.bovis_AF2122/97 ACVVCAIGLGSVAGLS-RVFDRAAISRRSGCHLLLLAVLAAIALADLSML
MMAR_0887|M.marinum_M ACVVCAIGLGSVAGIS-RVVDAAAIRRRSGLHLLLLGMVAAILVADLSML
MUL_0640|M.ulcerans_Agy99 ACVVCAIGLGSVAGIS-RVVDAAAIRRRSGLHLPLLGMVAAILVADLSML
MAV_4603|M.avium_104 ACVVCAIGLGGVAGVG-RVFDRAAIRRRSGFPLLLLAVLAAAACADLSML
MSMEG_0999|M.smegmatis_MC2_155 ASVVCAIGLGSVAGIG-RVFDIKAARRNPGLPMLVIGALLAITFADLSML
Mvan_0891|M.vanbaalenii_PYR-1 ASVVCAIGLGSVAGLG-RVFDIAAIKRRSGLHLLVLGALLAIVVADLSRL
MAB_4441|M.abscessus_ATCC_1997 GCRIDTPRTGDRLGTGTQIVAGTAWAQHRGIATVEVQIDDGPWLPARLAP
.. : : *. * . ::. * :. * : . .
Rv0541c|M.tuberculosis_H37Rv SKAETERIWLPFTIWLTAAPALLPPRSHRLWLAVN--------AAGALLL
Mb0555c|M.bovis_AF2122/97 SKAETERIWLPFTIWLTAAPALLPPRSHRLWLAVN--------AAGALLL
MMAR_0887|M.marinum_M SKAETERIWLPFTVWLTTAPALLRPRSDRLWLAVN--------AAGALAV
MUL_0640|M.ulcerans_Agy99 SKAETERIWLPFTVWLTTAPALLRPRSDRLWLAVN--------AAGALAV
MAV_4603|M.avium_104 SKAEVERIWLPFTIWLTAAAALLPVRTHRIWLALN--------AVGALAV
MSMEG_0999|M.smegmatis_MC2_155 SKAETERIWLPFTVWLTAAGALLPPRSHRWWLGLN--------VAGALAL
Mvan_0891|M.vanbaalenii_PYR-1 SKAETERIWLPFTVWLVASTALLPPRSARWWLALN--------VIGALAI
MAB_4441|M.abscessus_ATCC_1997 EYSVDTWRQWWFAWQATAGEHIITARATDGTGAVQTDQIASPVPDGATGY
. : *: .:. :: *: .:: **
Rv0541c|M.tuberculosis_H37Rv NSIIFTNW-
Mb0555c|M.bovis_AF2122/97 NSIIFTNW-
MMAR_0887|M.marinum_M NSIIFTNW-
MUL_0640|M.ulcerans_Agy99 NSIIFTNW-
MAV_4603|M.avium_104 NTIILTHW-
MSMEG_0999|M.smegmatis_MC2_155 NHLILTNW-
Mvan_0891|M.vanbaalenii_PYR-1 NHLILTNW-
MAB_4441|M.abscessus_ATCC_1997 PKRLVTVAA
:.*