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KIPGVATVLGGVTNGVAQTVRAGARLPGSAAAAVQTLASPVLELTGPVVQSVVQTTGRAIGVRGSHNESP DGMTPPVRWRSGRRVHFDLDPLLPFPRWHEHAAMVEEPVRRIPGVAEAHVEGSLGRLVVELEPDADSDIA VDEVRDVVSAVAADIFLAGSVSSPNSAPFADPGNPLAILVPLTAAAMDLVAMGATVTGWVARLPAAPQTT RALAALINHQPRMVSLMESRLGRVGTDIALAATTAAANGLTQSLGTPLLDLVQRSLQISEAAAHRRVWRD REPALASPRRPQAPVVPIISSAGAKSQEPRHSWAAAAAGEASHVVVGGSIDAAIDTAKGSRAGPVEQYVN QAANGSLIAAASALVAGGGTEDAAGAILAGVPRAAHMGRQAFAAVLGRGLANTGQLVLDPGALRRLDRVR VVVIDGAALRGDNRAVLHAQGDEPGWDDDRVYEVADALLHGEQAPEPDPDELPATGARLRWAPAQGPSAT PAQGLEHADLVVDGQCVGSVDVGWEVDPYAIPLLQTAHRTGARVVLRHVAGTEDLSASVGSTHPPGTPLL KLVRELRADRGPVLLITAVHRDFASTDTLAALAIADVGVALDDPRGATPWTADLITGTDLAAAVRILSAL PVARAASESAVHLAQGGTTLAGLLLVTGEQDKTTNPASFRRWLNPVNAAAATALVSGMWSAAKVLRMPDP TPQPLTAWHALDPEIVYSRLAGGSRPLAVEPGIPAWRRILDDLSYEPVMAPLRGPARTLAQLAVATRHEL ADPLTPILAVGAAASAIVGSNIDALLVAGVMTVNAITGGVQRLRAEAAAAELFAEQDQLVRRVVVPAVAT TRRRLEAARHATRTATVSAKSLRVGDVIDLAAPEVVPADARLLVAEDLEVDESFLTGESLPVDKQVDPVA VNDPDRASMLFEGSTIVAGHARAIVVATGVGTAAHRAISAVADVETAAGVQARLRELTSKVLPMTLAGGA AVTALALLRRASLRQAVADGVAIAVAAVPEGLPLVATLSQLAAAQRLTARGALVRSPRTIEALGRVDTIC FDKTGTLTENRLRVVCALPSSTAAERDPLPQTTDAPSAEVLRAAARASTQPHNGEGHAHATDEAILAAAS ALAGSLSSQGDSEWVVLAEVPFESSRGYAAAIGRVGTDGIPMLMLKGAPETILPRCRLADPGVDHEHAES VVRHLAEQGLRVLAVAQRTWDNGTTHDDETDADAVDAVAHDLELIGYVGLADTARSSSRPLIEALLDAER NVVLITGDHPITARAIARQLGLPADARVVTGAELAVLDEEAHAKLAADMQVFARVSPEQKVQIVAALQRC GRVTAMVGDGANDAAAIRMADVGIGVSGRGSSAARGAADIVLTDDDLGVLLDALVEGRSMWAGVRDAVTI LVGGNVGEVLFTVIGTAFGAGRAPVGTRQLLLVNLLTDMFPALAVAVTSQFAEPDDAEYPTDDAAERAQR EHRRAVLIGPTPSLDAPLLRQIVNRGVVTAAGATAAWAIGRWTPGTERRTATMGLTALVMTQLAQTLLTR RHSPLVIATALGSAGVLVGIIQTPVISHFSGVPRWDRSPGRASSAPRQEPPQSQRWHRSGWQAQSVSCNL MNALTTRKTLTRVDRTYRRPR*
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. tuberculosis H37Rv | Rv0107c | ctpI | - | 100% (1632) | PROBABLE CATION-TRANSPORTER ATPASE I CTPI |
M. tuberculosis H37Rv | Rv0425c | ctpH | 0.0 | 36.81% (1584) | metal cation transporting P-type ATPase CtpH |
M. tuberculosis H37Rv | Rv1997 | ctpF | 5e-85 | 33.13% (812) | metal cation transporter P-type ATPase A CtpF |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb0111c | ctpI | 0.0 | 99.75% (1572) | cation-transporter ATPase I |
M. gilvum PYR-GCK | Mflv_0956 | - | 5e-84 | 32.58% (841) | ATPase, P-type (transporting), HAD superfamily, subfamily IC |
M. leprae Br4923 | MLBr_02671 | - | 0.0 | 81.82% (1573) | putative cation transport ATPase |
M. abscessus ATCC 19977 | MAB_0962 | - | 1e-44 | 27.15% (755) | cation-transporting ATPase E |
M. marinum M | MMAR_0297 | ctpI | 0.0 | 85.73% (1577) | cation-transporter ATPase I CtpI |
M. avium 104 | MAV_5219 | - | 0.0 | 84.46% (1557) | ATPase, P-type (transporting), HAD superfamily protein, subfamily |
M. smegmatis MC2 155 | MSMEG_3926 | - | 6e-79 | 31.66% (796) | cation-transporting ATPase Pma1 |
M. thermoresistible (build 8) | TH_2876 | - | 1e-176 | 34.06% (1471) | PUTATIVE ATPase, P-type (transporting), HAD superfamily, |
M. ulcerans Agy99 | MUL_4826 | ctpI | 0.0 | 85.48% (1577) | cation-transporter ATPase I CtpI |
M. vanbaalenii PYR-1 | Mvan_1651 | - | 0.0 | 35.72% (1590) | ATPase, P-type (transporting), HAD superfamily, subfamily IC |
CLUSTAL 2.0.9 multiple sequence alignment Mflv_0956|M.gilvum_PYR-GCK -------------------------------------------------- MSMEG_3926|M.smegmatis_MC2_155 -------------------------------------------------- Rv0107c|M.tuberculosis_H37Rv MKIPG----VATVLGGVTNGVAQTVRAGARLPGSAAAAVQTLASPVLELT Mb0111c|M.bovis_AF2122/97 MKIPG----VATVLGGVTNGVAQTVRAGARLPGSAAAAVQTLASPVLELT MMAR_0297|M.marinum_M MKIPGVVNPVANLVAGVTGGAAQVVRAGVQTAADAAGVLQTLASPVVELA MUL_4826|M.ulcerans_Agy99 MKIPGVVNPVANLVAGVTGGAVQMVRAGVQTAADAAGVLQTLASPVVELA MAV_5219|M.avium_104 -----------------------MVRAGVSTAAGAAGALQTLASPVAELA MLBr_02671|M.leprae_Br4923 MKIPHVTDPVSNMVG----GMAQVVRASTHAATGAVNTMQMLASPVAEFA TH_2876|M.thermoresistible__bu ------MGVLRSTVGGLIGASLRTLQVAAGTALLAGDTVIGAGRTVAGTV Mvan_1651|M.vanbaalenii_PYR-1 ---------------------------------MVTDVASGAASTAR-AA MAB_0962|M.abscessus_ATCC_1997 -------------------------------------------------- Mflv_0956|M.gilvum_PYR-GCK -------------------------------------------------- MSMEG_3926|M.smegmatis_MC2_155 -------------------------------------------------- Rv0107c|M.tuberculosis_H37Rv GPVVQSVVQTTGRAIGVRGSHNESPDGMTPPVRWRSGRRVHFDLDPLLPF Mb0111c|M.bovis_AF2122/97 GPVVQSVVQTTGRAIGVRGSHNESPDGMTPPVRWRSGRRVHFDLDPLLPF MMAR_0297|M.marinum_M APVVQSVAQTTNRAIGRNGAADRAPDGVTPPLRWHSGRRVHFDLDPLLPF MUL_4826|M.ulcerans_Agy99 GPVVQSVAQTTNRAIGRNGAADGAPDGVTPPLRWHSGRRVHFDLDPLLPF MAV_5219|M.avium_104 GPVIQSMAQTTGRAIGLDGSADGAP-AIVPPVRWHSGRRVHLDLDPLLPF MLBr_02671|M.leprae_Br4923 WPVVQSVAKSTGRALG-TGHSPNFANRVDPPVRWHNGQRVHLDLDPLLPF TH_2876|M.thermoresistible__bu ADLAADVATGAESTAHTTLGLVVEALGGPPARRTSRNDSRHWIEVCGLSG Mvan_1651|M.vanbaalenii_PYR-1 AGMVQDAAAGAPAAVQTAAAITTEALGGHPVKRSSRLNSHHWIEICGLSG MAB_0962|M.abscessus_ATCC_1997 -------------------------------------------------- Mflv_0956|M.gilvum_PYR-GCK -------------------------------------------------- MSMEG_3926|M.smegmatis_MC2_155 -------------------------------------------------- Rv0107c|M.tuberculosis_H37Rv PRWHEHAAMVEEPVRRIPGVAEAHVEGSLGRLVVELEPDADSDIAVDEVR Mb0111c|M.bovis_AF2122/97 PRWHEHAAMVEEPVRRIPGVAEAHVEGSLGRLVVELEPDVDSDIAVDEVR MMAR_0297|M.marinum_M PRWHEHAAVVEEPVRRIPGVAKAHVEGALGRLVVELEDGADSDTVLDEVC MUL_4826|M.ulcerans_Agy99 PRWHEHAAVVEEPVRRIPGVAKAHVEGALGRLVVELEDGADSDTVLDEVC MAV_5219|M.avium_104 PRWHEYAPAVEEPVRRIPGVAKAHVEGSLGRLVVELADDADNAAVLDEVR MLBr_02671|M.leprae_Br4923 PRWHEYAAVVEEPVRRIPGVAKGHVEGSLGRLVIELDKNADSDVVLGKVR TH_2876|M.thermoresistible__bu PDADAIAEEVVSALRAVPGVTDVAINHSMARAVVTVETGVPAADLTAVVA Mvan_1651|M.vanbaalenii_PYR-1 PDADAIADEVLAAVHAVAGVRHAEINRSVARVIVTTEPEGPAENLAQVVA MAB_0962|M.abscessus_ATCC_1997 -------------------------------------------------- Mflv_0956|M.gilvum_PYR-GCK -------------------------------------------------- MSMEG_3926|M.smegmatis_MC2_155 -------------------------------------------------- Rv0107c|M.tuberculosis_H37Rv DVVSAVAADIFLAGSVSSPNSAPFADPGNPLAILVPLTAAAMDLVAMGAT Mb0111c|M.bovis_AF2122/97 DVVSAVAADIFLAGSVSSPNSAPFADPGNPLAILVPLTAAAMDLVAMGAT MMAR_0297|M.marinum_M DTAATVAADIFLSGSLSSPNSAPFADPGNPLAVLVPLTAAALDLAALGAA MUL_4826|M.ulcerans_Agy99 DTAATVAADIFLSGSASSPNSAPFADPGNPLAVLVPLTAAALDLAALGAA MAV_5219|M.avium_104 STVASVAADISWSKAEAAPPSAPFADPGNPLAILVPLTAAALDLVAMGAA MLBr_02671|M.leprae_Br4923 DVVIALAADLALTGARSAPKVAPFADPGNPLAILMPLTAAVMDLVALSAA TH_2876|M.thermoresistible__bu EAERRART------TEAG-RHRPHTLPWDDALLAARAVGAAAAAVGLGLS Mvan_1651|M.vanbaalenii_PYR-1 DAERRVRT------GPCGDRHRPLTLPGDDALLAARTLGALAAVAGFGLS MAB_0962|M.abscessus_ATCC_1997 -------------------------------------------------- Mflv_0956|M.gilvum_PYR-GCK -------------------------------------------------- MSMEG_3926|M.smegmatis_MC2_155 -------------------------------------------------- Rv0107c|M.tuberculosis_H37Rv VTGWVARLPAAPQTTRALAALINHQPRMVSLMESRLGRVGTDIALAATTA Mb0111c|M.bovis_AF2122/97 VTGWVARLPAAPQTTRALAALINHQPRMVSLMESRLGRVGTDIALAATTA MMAR_0297|M.marinum_M VTGWVIRLPAAPQTTRAAAALINHQPRMVSLLESRLGRVGTDIALAATTA MUL_4826|M.ulcerans_Agy99 VTGWVIRLPAAPQTTRAAAALINHQPRMVSLLESRLGRVGTDIALAATTA MAV_5219|M.avium_104 VTGWVTRLPAAPQTTRAAAALINHQPRMVSILEARLGRVGTDIALAATTA MLBr_02671|M.leprae_Br4923 VTGWVTRLPAVPQTIRAAAALVNHQPRMVSLLESRLGRVGTDIALSITTA TH_2876|M.thermoresistible__bu VTGNVLRFRGLPDFLSAIPTLADHNPGIHRQFERRLGREGTDLLFSLLTS Mvan_1651|M.vanbaalenii_PYR-1 VTGNALRVPRVMELLAVVPTMAANVPQLRRQFEHRLGRDSTDLLLSLMNA MAB_0962|M.abscessus_ATCC_1997 -------------------------------------------------- Mflv_0956|M.gilvum_PYR-GCK -------------------------------------------------- MSMEG_3926|M.smegmatis_MC2_155 -------------------------------------------------- Rv0107c|M.tuberculosis_H37Rv AANGLTQSLGTPLLDLVQRSLQISEAAAHRRVWRDREPALASPRRPQAPV Mb0111c|M.bovis_AF2122/97 AANGLTQSLGTPLLDLVQRSLQISEAAAHRRVWRDREPALASPRRPQAPV MMAR_0297|M.marinum_M AANGLTQAVGTPLLDLVQRGLQISEATAHRRVWRDREPALASPGRPQAPV MUL_4826|M.ulcerans_Agy99 AANGLTQAVSTPLLDLVQRGLQISEATAHRRVWRDREPALASPGRPQAPV MAV_5219|M.avium_104 AAHGLTQSFGTPLLDLTQRTLQISEAAAHRRVWRDREPQLASPDRPQAPV MLBr_02671|M.leprae_Br4923 AASGLTQAVGTPLLDLACRGLQLSEAAAHQRVWRDREPQLASPKRPQAPV TH_2876|M.thermoresistible__bu ASAAMTVSPTSAAAEMATRTMMVVEAVHTRRAWRRHEPRLVRHR------ Mvan_1651|M.vanbaalenii_PYR-1 AASALTASPTSAAAEAATRTLLAAEAWDARVAWRRHEPRLAAYP------ MAB_0962|M.abscessus_ATCC_1997 -------------------------------------------------- Mflv_0956|M.gilvum_PYR-GCK -------------------------------------------------- MSMEG_3926|M.smegmatis_MC2_155 -------------------------------------------------- Rv0107c|M.tuberculosis_H37Rv VPIISSAGAKSQEPRHSWAAAAAGEASHVVVGGSIDAAIDTAKGSRAGPV Mb0111c|M.bovis_AF2122/97 VPIISSAGAKSQEPRHSWAAAAAGEASHVVVGGSIDAAIDTAKGSRAGPV MMAR_0297|M.marinum_M VPVISSAGVQAQEPRHSWAAAAAGEASHVMVGGSIDAAIDTAKGSMAGPV MUL_4826|M.ulcerans_Agy99 VPVISSAGVQAQEPRHSWAAAAAGEASHVMVGGSIDAAIDTAKGSMAGPV MAV_5219|M.avium_104 VPVISSA--KSEVPRHSWAAAAAGEASHVVVGGTIDAAMDKAKGSMAGPV MLBr_02671|M.leprae_Br4923 VPVISSAGEKSHAAGHNWTAAASNEASHLVVGGSIDAAIDTAKGSMKGPV TH_2876|M.thermoresistible__bu -------------PSSRRPHRGTLEFG-------------------AGAG Mvan_1651|M.vanbaalenii_PYR-1 -------------PEGGFPDRGTLEWD-------------------YGPS MAB_0962|M.abscessus_ATCC_1997 -------------------------------------------------- Mflv_0956|M.gilvum_PYR-GCK -------------------------------------------------- MSMEG_3926|M.smegmatis_MC2_155 -------------------------------------------------- Rv0107c|M.tuberculosis_H37Rv EQYVNQAANGSLIAAASALVAGGGTEDAAGAILAGVPRAAHMGRQAFAAV Mb0111c|M.bovis_AF2122/97 EQYVNQAANGSLIAAASALVAGGGTEDAAGAILAGVPRAAHMGRQAFAAV MMAR_0297|M.marinum_M ESYVNSAANGALIAAASALVAGGGTEDAAGAILAGVPRAAHMGRQAFAAV MUL_4826|M.ulcerans_Agy99 ESYVNSAANGALIAAASALVAGGGTEDAAGAILAGVPRAAHMGRQAFAAV MAV_5219|M.avium_104 ESYVDSAANGSLIAAVSALVAGGGTEDAAAAIEAGVPRAAHMGRQAFAAV MLBr_02671|M.leprae_Br4923 ESYVDSAANGSLIAAASALLAGGGTEDAAGAILAGVPRAAHMGQQAFAAT TH_2876|M.thermoresistible__bu ERYADRAVRMGVTAAAVVGAVSRNPTIGGAAALVTAPKPSRAAREAFGCA Mvan_1651|M.vanbaalenii_PYR-1 ERYAERIGEAGLAAATIIGAVTRNPTIAASAALVTAPKPSRAARDAFGAA MAB_0962|M.abscessus_ATCC_1997 -------------------------------------------------- Mflv_0956|M.gilvum_PYR-GCK -------------------------------------------------- MSMEG_3926|M.smegmatis_MC2_155 -------------------------------------------------- Rv0107c|M.tuberculosis_H37Rv LGRGLANT-GQLVLDPGALRRLDRVRVVVIDGAALRGDNRAVLHAQGDEP Mb0111c|M.bovis_AF2122/97 LGRGLANT-GQLVLDPGALRRLDRVRVVVIDGAALRGDNRAVLHAQGDEP MMAR_0297|M.marinum_M LGRGLASE-GQLVLDPGALRRLDRVQVVVIDGAALRGDHRAVLRAQGDEP MUL_4826|M.ulcerans_Agy99 LGRGLASE-GQLVLDPGALRRLDRVQVVVIDGAALRGDHRSVLRAQGDEP MAV_5219|M.avium_104 LGRGLANS-GQLVLDPGALRRLDRVKVVVIDGAALRGDHRAVLRVRGEAP MLBr_02671|M.leprae_Br4923 LGRGLANA-GQLVLDPGALRRLDQVKVVVIDGAALRGDHRAVLLARGNTP TH_2876|M.thermoresistible__bu MTRGLITHHDALVVRPRALRALDRVDAVVIDPRVLYTDQLAVTRIVGVTN Mvan_1651|M.vanbaalenii_PYR-1 MTRGLTNQHDVVVVRPRALRHLDRLDAIVIDPRALYTDKLTVTRIVGVTN MAB_0962|M.abscessus_ATCC_1997 -------------------------------------------------- Mflv_0956|M.gilvum_PYR-GCK -------------------------------------------------- MSMEG_3926|M.smegmatis_MC2_155 -------------------------------------------------- Rv0107c|M.tuberculosis_H37Rv GWDDDRVYEVADALLHGEQAPEPDPDELPATGARLRWAPAQGPSATPAQG Mb0111c|M.bovis_AF2122/97 GWDDDRVYEVADALLHGEQAPEPDPDELPATGARLRWAPAQGPSATPAQG MMAR_0297|M.marinum_M GWDDDRVYEVADALLHGEEAPEPDPDELPATGARLRWVPLRGPSATPAQG MUL_4826|M.ulcerans_Agy99 GWDDDRVYEVADALLHGEEAPEPDPDELPATGARLRWVPLRGPSATPAQG MAV_5219|M.avium_104 GWDDDRVYEVADALLHGEEAPEPDPDELPATGARLRWVPSQGPSAMPAQG MLBr_02671|M.leprae_Br4923 GWDDDRVYEVTDALLHGERAPEPDPDESPATGARLRWVPLQGPSATPVQG TH_2876|M.thermoresistible__bu SDRDRAWRAVQRALDRGGLTP----------------------------G Mvan_1651|M.vanbaalenii_PYR-1 SRRTHAWEAVRAALDADSMSP----------------------------G MAB_0962|M.abscessus_ATCC_1997 -------------------------------------------------- Mflv_0956|M.gilvum_PYR-GCK -------------------------------------------------- MSMEG_3926|M.smegmatis_MC2_155 -------------------------------------------------- Rv0107c|M.tuberculosis_H37Rv LEHADLVVDGQCVGSVDVGWEVDPYAIPLLQTAHRTGARVVLRHVAGTED Mb0111c|M.bovis_AF2122/97 LEHADLVVDGQCVGSVDVGWEVDPYAIPLLQTAHRTGARVVLRHVAGTED MMAR_0297|M.marinum_M LEHADLVVDGQTVGNVDVGWEVDPYAIPLLQTAHRTGARVVLRHVAGTED MUL_4826|M.ulcerans_Agy99 LEHADLVVDGQTVGNVDVGWEVDPYAIPLLQTAHRTGARVVLRHVAGTED MAV_5219|M.avium_104 LESADLIVDGDRVGRVDVGWEVDPYAIPLFQTAHRTGARVVLRHVAGTED MLBr_02671|M.leprae_Br4923 REHADLVVNGECVGGVDVGWEVDPYAIPLLQTAHRTGARVVLRHVAGTED TH_2876|M.thermoresistible__bu WHPLSSIAGAPASGRILISPVRDQFAAAVVTEAHRCGRRVLSLDDDGLRS Mvan_1651|M.vanbaalenii_PYR-1 WHKLSTIPGAGRAGKALVSPVRDPLANAVVTEARRTKPRVVSIADDGLRS MAB_0962|M.abscessus_ATCC_1997 -------------------------------------------------- Mflv_0956|M.gilvum_PYR-GCK -------------------------------------------------- MSMEG_3926|M.smegmatis_MC2_155 -------------------------------------------------- Rv0107c|M.tuberculosis_H37Rv LSASVGSTHPPGTPLLKLVRELRADRGPVLLITAVHRDFASTDTLAALAI Mb0111c|M.bovis_AF2122/97 LSASVGSTHPPGTPLLKLVRELRADRGPVLLITAVHRDFASTDTLAALAI MMAR_0297|M.marinum_M LSASVGSTHPPGTPLLNLVRELRTDRGPVLLITALHRDFASTDTLAALAI MUL_4826|M.ulcerans_Agy99 LSASVGSTHPPGTPLLNLVRELRTDPGPVLLITALHRDFASTDTLAALAI MAV_5219|M.avium_104 LTASVGATHPPGTPLLNVVRELRADRGPVLLITALHRDFASTDTLAALAI MLBr_02671|M.leprae_Br4923 LSASVGATHPPGTPLLKLVRELRTDRGPVLLITAVHRDFASTDTLAALAI TH_2876|M.thermoresistible__bu LARGFDKLYPLGD----SVDESLAAAVAEAKADGATVALFTSPAMTAPHA Mvan_1651|M.vanbaalenii_PYR-1 LAQGFDRLYPVDG----SIDEALAAAVDELKADGATVALLTTPDLSANQD MAB_0962|M.abscessus_ATCC_1997 -------------------------------------------------- Mflv_0956|M.gilvum_PYR-GCK -------------------------------------------------- MSMEG_3926|M.smegmatis_MC2_155 -------------------------------------------------- Rv0107c|M.tuberculosis_H37Rv ADVGVALDDPRGATPWTADLITGTDLAAAVRILSALPVARAASESAVHLA Mb0111c|M.bovis_AF2122/97 ADVGVALDDPRGATPWTADLITGTDLAAAVRILSALPVARAASESAVHLA MMAR_0297|M.marinum_M ADIGVALDDPRAATPWTADIITGTDLAAAVRILSAIPVARASSVSSVHLA MUL_4826|M.ulcerans_Agy99 ADIGVALDDPRAATPWTADIITGTDLAAAVRILSAIPVARASSVSSVHLA MAV_5219|M.avium_104 ADVGVALDDPRAATAWTADIITGTDLADAVRILSAIPVARSASESAVHLA MLBr_02671|M.leprae_Br4923 ADVGVALDDPHAATPWTADIITGTDLAAAVRILSALPVARSASESSVHLA TH_2876|M.thermoresistible__bu ADITIGLSPDGHPPPWGADVFVP-DLVSMWRILRALPAARSATTKGVRLS Mvan_1651|M.vanbaalenii_PYR-1 ADLTIGLERPGWPPPWGADVFVP-DLLSVWRILHSLPTARAVTARGVRLS MAB_0962|M.abscessus_ATCC_1997 -------------------------------------------------- Mflv_0956|M.gilvum_PYR-GCK -------------------------------------------------- MSMEG_3926|M.smegmatis_MC2_155 -------------------------------------------------M Rv0107c|M.tuberculosis_H37Rv QGGTTLAGLLLVTGEQ-DKTTNPASFRRWLNPVNAAAATALVSGMWSAAK Mb0111c|M.bovis_AF2122/97 QGGTTLAGLLLVTGEQ-DKTTNPASFRRWLNPVNAAAATALVSGMWSAAK MMAR_0297|M.marinum_M QGGTTLAGLLLVTGEQ-AKTTNPASFRRWLNPVNTAAATALLSGSWSAAT MUL_4826|M.ulcerans_Agy99 QGGTTLAGLLLVTGEQ-ARTTNPASFRRWLNPVNTAAATALLSGSWSAAT MAV_5219|M.avium_104 QGGTTLAGLLLVTGEQ-EKGASPVSFRRWLNPVNAAAATALVAGTFSATR MLBr_02671|M.leprae_Br4923 QGGTTLAGLLLITASAGSKSASPITLRRWFSPVNAAAATALVTGVVSASK TH_2876|M.thermoresistible__bu ASSTAIGALMLIPGVT----------GNGPDSVNVGVAAGLWSGFRTATK Mvan_1651|M.vanbaalenii_PYR-1 VSATTLGALMLIPGVP----------GSGPESVSVGVVGALWSGFTAGSK MAB_0962|M.abscessus_ATCC_1997 -------------------------------------------------- Mflv_0956|M.gilvum_PYR-GCK -----------MSDWHARSVREVTDALDTDVTAGLTSEAAEERRHRHGPN MSMEG_3926|M.smegmatis_MC2_155 RRPADAGGNSNENNWHTMQPDEVLDALGASR-SGLTDSEVERRRAVHGWN Rv0107c|M.tuberculosis_H37Rv VLRMPDPTPQPLTAWHALDPEIVYSRLAGGSRPLAVEPGIPAWRRILDDL Mb0111c|M.bovis_AF2122/97 VLRMPDPTPQPLTAWHALDPEIVYSRLAGGSRPLAVEPGIPAWRRILDDL MMAR_0297|M.marinum_M VLRLPDPTPQPLTAWHALDPEIVYARLAGGARPMAVDPGTPTWRRLLDDL MUL_4826|M.ulcerans_Agy99 VLRLPDPTPQPLTAWHALDPEIVYARLAGGARPMAVDPGTPTWRRLLDDL MAV_5219|M.avium_104 VLRLPDPTPQPLTAWHALDPEIVYSRLAGGARPLAVET-EPSWRRRLDDL MLBr_02671|M.leprae_Br4923 VLRLPDPTPQPLTAWHALDPEIVYSRLAGVTQPLAVEPGTPDWRRRLDDL TH_2876|M.thermoresistible__bu VFDDSPPEPEPSHDWHALPADEVRRLLP---RPGDGDRQPPAGRDPALMR Mvan_1651|M.vanbaalenii_PYR-1 VFRDPPPEPESVHDWHAMPVAEVERLLP---RPPD--EEPDVSTGLTDLP MAB_0962|M.abscessus_ATCC_1997 -----------MATIEGLTISGLTAAEVAERVAQGKTNDVPSRAARSVSD . : . Mflv_0956|M.gilvum_PYR-GCK QLTEAAA---------VPVWRKVLRLLADKMTLVLLVAAAVSAVVSREWE MSMEG_3926|M.smegmatis_MC2_155 RLAAVRK---------QSALVPFIRQFHNVLIYVMSCAAIVTAVLQ-HWV Rv0107c|M.tuberculosis_H37Rv SYEPVMAPLRGPARTLAQLAVATRHELADPLTPILAVGAAASAIVG-SNI Mb0111c|M.bovis_AF2122/97 SYEPVMAPLRGPARTLAQLAVATRHELADPLTPILAVGAAASAIVG-SNI MMAR_0297|M.marinum_M SYEPLVSPLRGPAHTLAQLAAATRHELADPLTPILAVGAAASAIVG-SNV MUL_4826|M.ulcerans_Agy99 SYEPLVSPLRGPAHTLAQLAAATRHELADPLTPILAVGAAASAIVG-SNV MAV_5219|M.avium_104 SYSPALAPLRAPLQNVLRLASATRTELADPLTPILAVGAAASAIVG-SNI MLBr_02671|M.leprae_Br4923 SYTRALSPLRKPVTKLARLASATRQEFADPLTPILAVGAAASAIVG-SNI TH_2876|M.thermoresistible__bu PVRAAAAAMTWFWQLTRDFTAEMRSNLADPITPLLATGAVASALLG-SPL Mvan_1651|M.vanbaalenii_PYR-1 PLRALSQAGTWSWHLTRDFVAEMRTNLSDPITPLLATGAVASALLG-SPL MAB_0962|M.abscessus_ATCC_1997 IVR-------------ANVFTRINAILGVLLIIVLSTGSIINGAFG---- : : :: .: .. . Mflv_0956|M.gilvum_PYR-GCK TPVVIMLVVTLNTVLNYVQEARAENSLQALRDMSISYSR----------- MSMEG_3926|M.smegmatis_MC2_155 DAAVLFAAVLINVVIAYVQEGRAQAALDAIRAMMSPHAT----------- Rv0107c|M.tuberculosis_H37Rv DALLVAGVMTVNAITGGVQRLRAEAAAAELFAEQDQLVRRVVVPAVATTR Mb0111c|M.bovis_AF2122/97 DALLVAGVMTVNAITGGVQRLRAEAAAAELFAEQDQLVRRVVVPAVATTR MMAR_0297|M.marinum_M DALLVAGVMTVNAITGGVQRLRAEAAAAELFAEQDQMVRRVVVPAVATTR MUL_4826|M.ulcerans_Agy99 DALLVAGVMTVNAITGGVQRLRAEAAAAELFAEQDQMVRRVVVPAVATTR MAV_5219|M.avium_104 DALLVAGVMTVNAITGGAQRLRAESAAAELFAEQDQMVRRVVVPAVATTR MLBr_02671|M.leprae_Br4923 DALLVAGVMTVNAITGGVQRLRAEAAAAELFAEQDQLVRRVVVPAVATTR TH_2876|M.thermoresistible__bu DAALVGGVLLLNAALSAQQQLHAERILRRLMAVQEPSARRRVRMATATGT Mvan_1651|M.vanbaalenii_PYR-1 DAALVGGVLLANAALSAEQQLHAERILQRLMAVEEPLARRRVG------- MAB_0962|M.abscessus_ATCC_1997 ------LLIIANSAVGIIQELRAKQILDKLAIVGQTRPL----------- : * *. :*: : Mflv_0956|M.gilvum_PYR-GCK --------VRRDGGEHRLPRTELVPGDVVLLEAGDAVPADGRIVSAARLQ MSMEG_3926|M.smegmatis_MC2_155 --------VTRNGRTLDVEAVELVPGDVVQLAAGDRIPADLRLIGVDGLQ Rv0107c|M.tuberculosis_H37Rv R---RLEAARHATRTATVSAKSLRVGDVIDLAAPEVVPADARLLVAEDLE Mb0111c|M.bovis_AF2122/97 R---RLEAARHATRTATVSAKSLRVGDVIDLAAPEVVPADARLLVAEDLE MMAR_0297|M.marinum_M R---RLEAARHATRTATVSAKSLRVGDVIDLAAPEVVPADARLLVAEDLE MUL_4826|M.ulcerans_Agy99 R---RLEAARHATRTATVSAKSLRVGDVIDLAAPEVVPADARLLVAEDLE MAV_5219|M.avium_104 R---RLEAARHATRTATVSAKSLRPGDVIDLAAPEVVPADARLLEAEDLE MLBr_02671|M.leprae_Br4923 R---RLEAAQHATRTVTVSAKSLRAGDVIDLAAPEVVPADARVLVAEDLE TH_2876|M.thermoresistible__bu GATGTEATPVEAGPIEEVPANRLRPGDVIEVRVGDVVPADARIMAASNVE Mvan_1651|M.vanbaalenii_PYR-1 --------PLDQRRNERVSASRLRPGDIIEVHADEVVPADARLIEATNIE MAB_0962|M.abscessus_ATCC_1997 --------VRRDGAATALAPNEVVLDDIIELGPGDQIVVDGEVIEESALE : : .*:: : : : .* .:: :: Mflv_0956|M.gilvum_PYR-GCK VAESALTGESAPVDKAVDGLDDTDLPLGDRTNMLYMNTEVTRGRATMVVT MSMEG_3926|M.smegmatis_MC2_155 VDEAPLTGESAPVWKTIG-VDDEDTSLPDRRSMAYSGTLAIHGQATGVVV Rv0107c|M.tuberculosis_H37Rv VDESFLTGESLPVDKQVDPVAVN---DPDRASMLFEGSTIVAGHARAIVV Mb0111c|M.bovis_AF2122/97 VDESFLTGESLPVDKQVDPVAVN---DPDRASMLFEGSTIVAGHARAIVV MMAR_0297|M.marinum_M VDESLLTGESLPVDKQVDPVAVN---DADRASMLFEGSTIVAGRARAIVV MUL_4826|M.ulcerans_Agy99 VDESLLTGESLPVDKQVDPVAVN---DADRASMLFEGSTIVAGRARAIVV MAV_5219|M.avium_104 VDESLLTGESLPVDKQVEPVAVN---DPDRASMLFEGSTIVAGHARAIVV MLBr_02671|M.leprae_Br4923 VDESLLTGESLPVDKRVDPVAIN---DADRASMLFEGSAIVAGHARAIVV TH_2876|M.thermoresistible__bu VDESSLTGESLPVPKTAAATPGAP--LAERSGMLYAGTTMVAGTAVAVVT Mvan_1651|M.vanbaalenii_PYR-1 VDESSLTGESLPVPKQTDPTPGAP--LAERACMLYAGSTLVAGTAVAVVT MAB_0962|M.abscessus_ATCC_1997 IDESLLTGEADAIEKTIG-------------SQVLSGSFVVAGSGAYRAT : *: ****: .: * .: * . .. Mflv_0956|M.gilvum_PYR-GCK ATGMDTEVGAIATMLGTAGVSRTPLQQRIDNLAQMLTVVALLVVIVVTVL MSMEG_3926|M.smegmatis_MC2_155 GTGAQTELGRINHLLTGVAPTATPLLRQISRFGRVLAVVILLLSAATYAL Rv0107c|M.tuberculosis_H37Rv ATGVGTAAHRAISAVADVETAAG-VQARLRELTSKVLPMTLAGGAAVTAL Mb0111c|M.bovis_AF2122/97 ATGVGTAAHRAISAVADVETAAG-VQARLRELTSKVLPMTLAGGAAVTAL MMAR_0297|M.marinum_M ATGAGTAAHRAISAVADVETSAG-VQARLRELTSKVLPLTLAGGASVSVL MUL_4826|M.ulcerans_Agy99 ATGAGTAAHRAISAVADVETSAG-VQARLRELTSKVLPLTLAGGASVSVL MAV_5219|M.avium_104 ATGVGTAAHRAISAVADVETAAG-VQARLRELTSKVLPLTLAGGAAVSTL MLBr_02671|M.leprae_Br4923 ATGVGTAAHRAISAVADVEVSAG-VQARLRELTSKVLPLTLAGGAAVTGL TH_2876|M.thermoresistible__bu AVGPRTEVRRALAMAAERPGEIG-LQRQLAHITKRALPFSVSSGALVGLL Mvan_1651|M.vanbaalenii_PYR-1 TVGSRTEMRRALAMAPDKSREIG-LQRQLSRITKRALPFSVGGGALVGLL MAB_0962|M.abscessus_ATCC_1997 KVGREAYAAKLAEEASKFTLVHSELRNGINKILQFITYLLLPAGALIIYT .* : : : .: . : Mflv_0956|M.gilvum_PYR-GCK G-LLRGDTWTELLLTAVSLAVATIPEGLTAVVAFTLAMGASRLARRGAII MSMEG_3926|M.smegmatis_MC2_155 GVIWRGETLTEMFMMTVALAASAIPEGLPAIMTVTLAIGVQRMSRRRAIV Rv0107c|M.tuberculosis_H37Rv A-LLRRASLRQAVADGVAIAVAAVPEGLPLVATLSQLAAAQRLTARGALV Mb0111c|M.bovis_AF2122/97 A-LLRRASLRQAVADGVAIAVAAVPEGLPLVATLSQLAAAQRLTARGALV MMAR_0297|M.marinum_M A-LMRRATLRQAVADGVAIAVAAVPEGLPLVATLSQLAAAQRLTAHGALV MUL_4826|M.ulcerans_Agy99 A-LMRRATLRQAVADGVAIAVAAVPEGLPLVATLSQLAAAQRLTAHGALV MAV_5219|M.avium_104 A-LLRRASLRQAVADGVAIAVAAVPEGLPLVATLSQLSAAQRLTARGALV MLBr_02671|M.leprae_Br4923 A-LLRRASLRQAVADGVAIAVAAVPEGLPLVATLSQLAAAQRLTAKGALV TH_2876|M.thermoresistible__bu S-VLRGTPIRAAVGSAVSLIVAAVPEGLPLVATLAQLASARRLSGESILI Mvan_1651|M.vanbaalenii_PYR-1 S-LARGTPLREAVGSSVALTVAAVPEGLPLVATLAQLASARRLTGESVLI MAB_0962|M.abscessus_ATCC_1997 QLFTTDDSWQESVLRMVGALVPMVPEGLVLMTSIAFAVGVIRLGRRQCLV . . . *. .. :**** : :.: .. *: . :: Mflv_0956|M.gilvum_PYR-GCK KQLSAVETLGSTADIATDKTGTLTLNEMTVRRLLLPGREFRVSGEGYSTD MSMEG_3926|M.smegmatis_MC2_155 CRLPAVEALGSVTVICTDKTGTLTSNEMTVQRVVCGGHDIDVGGVGYAPV Rv0107c|M.tuberculosis_H37Rv RSPRTIEALGRVDTICFDKTGTLTENRLRVVCALPSSTAAERDPL----- Mb0111c|M.bovis_AF2122/97 RSPRTIEALGRVDTICFDKTGTLTENRLRVVCALPSSTAAERDPL----- MMAR_0297|M.marinum_M RAPRTIEALGRVDTVCFDKTGTLTENRLRVVCAIPSSTSP-LDPF----- MUL_4826|M.ulcerans_Agy99 RAPRTIEALGRVDTVCFDKTGTLTENRLRVVCAIPSSTSP-LDPF----- MAV_5219|M.avium_104 RAPRTIEALGRVDTICFDKTGTLTENRLRVVCAVPDDVNP-HDPF----- MLBr_02671|M.leprae_Br4923 RSPRTIEALGRVDTICFDKTGTLTENRLRVVCAVPNTRMP-HDPL----- TH_2876|M.thermoresistible__bu RNPNSIEALARLQVVCFDKTGTLSENRLQVKAVHP--------------- Mvan_1651|M.vanbaalenii_PYR-1 RNAQSIEAMARLQVVCFDKTGTLSENRLRVKAVRP--------------- MAB_0962|M.abscessus_ATCC_1997 QELPAIEGLARVDTVCADKTGTLTENGMRLADVHFPDR------------ ::* :. :. ******: * : : Mflv_0956|M.gilvum_PYR-GCK GKILVS----DGRPLPDLTAPLLAMALCSDASVREG----SLVGDPTEGA MSMEG_3926|M.smegmatis_MC2_155 GDFSIDGRVIDPSRYPALMEALLAASLCNDASLDVEDEVWVITGDPTEAA Rv0107c|M.tuberculosis_H37Rv ------PQTTDAPSAEVLRAAARASTQPHNG--------EGHAHATDEAI Mb0111c|M.bovis_AF2122/97 ------PQTTDAPSAEVLRAAARASTQPHNG--------EGHAHATDEAI MMAR_0297|M.marinum_M ------IDSADPRSTEVLRAAARATTQPHDG--------QGHAHATDEAI MUL_4826|M.ulcerans_Agy99 ------IDSADPRSTEVLRAAARATTQPHDG--------QGHAHATDEAI MAV_5219|M.avium_104 ------PELTAPQSAELVRAAARASARPQEG--------QGHAHATDEAI MLBr_02671|M.leprae_Br4923 ------PDITDPHSAAVLRDAARASTQPHDG--------QGHTHATDEAI TH_2876|M.thermoresistible__bu ---------MRGRTETEVLEAALSTTFAEPG--------HRAHHATDEAI Mvan_1651|M.vanbaalenii_PYR-1 ---------IDGFTEEQALDAALSTIFVRAG--------HRAHHATDDAI MAB_0962|M.abscessus_ATCC_1997 ----------DGDEDALAVLAQLAADDPRPN-------------ASIAAI . : . . Mflv_0956|M.gilvum_PYR-GCK LVVLAEKGGVDVTGARAAIPRLAEVPFDSEYKYMATFCARSDLDGSGGH- MSMEG_3926|M.smegmatis_MC2_155 LLVVAKKAGLDHDRETVSHPRVATVPFASENRIMGTLHS--DVDRTP--- Rv0107c|M.tuberculosis_H37Rv LAAASALAGSLSSQGDSEWVVLAEVPFESSRGYAAAIGRVGT-DGIPM-- Mb0111c|M.bovis_AF2122/97 LAAASALAGSLSSQGDSEWVVLAEVPFESSRGYAAAIGRVGT-DGIPM-- MMAR_0297|M.marinum_M IVAANSLEG----LDDSAWTVIAEVPFESSRGYAASIGTTGTSNGHPT-- MUL_4826|M.ulcerans_Agy99 IVAANSLEG----LNDSAWTVIAEVPFESSRGYAASIGTTGTSNGHPT-- MAV_5219|M.avium_104 LTAASSLNG----QRDSDWSMIAEVPFESSRGFAAAIGTVGNANGNPSDT MLBr_02671|M.leprae_Br4923 LTAASSLNS----HTDSTWSLIAEVPFESSRGYAAAIGITGN-GKAPM-- TH_2876|M.thermoresistible__bu IRAVNG------AAIAAPAQRDGFLPFQAGRPYAAAVRGTRL-------- Mvan_1651|M.vanbaalenii_PYR-1 RRAVHGDED---AADTTEIERDAFLPFQAGRPFAAAIVGTRL-------- MAB_0962|M.abscessus_ATCC_1997 AEAYDTPPG---------WETTAIAPFSSAKKWSGASYGEHG-------- . . ** : .: Mflv_0956|M.gilvum_PYR-GCK -RCFVKGAPGVLLEHAGSVLGEDGPRPIDPGYRQRIRERVEQLASEGLRT MSMEG_3926|M.smegmatis_MC2_155 -LIVVKGAPERVLDICDSQRSPHGEEPLDRLYWQRMAA---TTAAQGLRV Rv0107c|M.tuberculosis_H37Rv --LMLKGAPETILPRCRLADPGVDHEHAESVVRH--------LAEQGLRV Mb0111c|M.bovis_AF2122/97 --LMLKGAPETILPRCRLADPGVDHEHAESVVRH--------LAEQGLRV MMAR_0297|M.marinum_M --LMLKGAPETILPRCRFADPDADLEHAEALVHS--------LAERGLRV MUL_4826|M.ulcerans_Agy99 --LMLKGAPETILPRCRFADPDADLEHAEALVHS--------LAERGLRV MAV_5219|M.avium_104 PVLILKGAPEVILPRCRFADPEADQQRAEAVVRG--------LAEQGLRV MLBr_02671|M.leprae_Br4923 --LMLKGAPEKILPRCRFADPEADVAHAESLVRH--------LAEQGLRV TH_2876|M.thermoresistible__bu ---TIKGAPEVLASALARGD-----SALTRRVEA--------MAAQGLRV Mvan_1651|M.vanbaalenii_PYR-1 ---TIKGAPEVLASALAQAN-----GPAVAAIDD--------MAAKGLRV MAB_0962|M.abscessus_ATCC_1997 --NWVIGAPDVLLDPA---------DAIATAAEE--------IGARGLRV : *** : . .***. Mflv_0956|M.gilvum_PYR-GCK LMIAGRDIDHDLPADPDGLQTLVDD-----LTVYAVVGIVDPPRPEAGEA MSMEG_3926|M.smegmatis_MC2_155 LAIARR-CGAPRNAGTLDIADLDSG-----FTMLGLVGIIDALRPEVAAA Rv0107c|M.tuberculosis_H37Rv LAVAQRTWDNGTTHDDETDADAVDAVAHD-LELIGYVGLADTARSSSRPL Mb0111c|M.bovis_AF2122/97 LAVAQRTWDNGTTHDDETDADAVDAVAHD-LELIGYVGLADTARPSSRPL MMAR_0297|M.marinum_M LAVAKRPWEHDTADDDDTDADAVDAAAHD-LELLGYVGLADTARPSARPL MUL_4826|M.ulcerans_Agy99 LAVAKRPWEHDTADDDDTDADAVDAAAHD-LELLGYVGLADTARPSARPL MAV_5219|M.avium_104 LAVAQRGWKHDTD-DDDTDADAVDAAAHN-LELLGYVGLADTARASARPL MLBr_02671|M.leprae_Br4923 LAVAQCSWGHDTTDDNDTDADAVDAAAHD-LELVGYIGLADTARPSSRPL TH_2876|M.thermoresistible__bu LAVAGRELSPEQAAAAVADPAVFTELCGSGLSLFGLIGLADTPRPSARGV Mvan_1651|M.vanbaalenii_PYR-1 IAVAERQLTPEQAAAAAADAAAFEELCRSDLTPIGLLGLADTPRASAQDV MAB_0962|M.abscessus_ATCC_1997 LLLASAELSVDDAHAPGAVTP------------RALVVLEQKIRPDARET : :* . : : : *.. Mflv_0956|M.gilvum_PYR-GCK IATAHAAGITVHMITGDHLSTAAAVAHDLGIPG--AAASG-ADLDRLDDD MSMEG_3926|M.smegmatis_MC2_155 VRECHRAGIRVKMITGDHAATAREIGAQLGIGIGKPAVIG-SEIASLNDT Rv0107c|M.tuberculosis_H37Rv IEALLDAERNVVLITGDHPITARAIARQLGLPADAR-VVTGAELAVLDEE Mb0111c|M.bovis_AF2122/97 IEALLDAERNVVLITGDHPITARAIARQLGLPADAR-VVTGAELAVLDEE MMAR_0297|M.marinum_M IEALVDAQRNVVLITGDHPITARAIARQLGLPEDVR-VVTGAELIGLDED MUL_4826|M.ulcerans_Agy99 IEALVDAQRNVVLITGDHPITARAIARQLGLPEDVR-VVTGAELIGLDED MAV_5219|M.avium_104 IEALLDAERDVVLITGDHPITARAIARQLGLPADAR-VVTGAELAGLDED MLBr_02671|M.leprae_Br4923 IEALVTAGRNVVLITGDHPITARAIAQQLGLRSDAR-VVNGTELIGLDED TH_2876|M.thermoresistible__bu LADLTERGIGVRLITGDHPVTAAVTARELGLDVDGEQVITGAEWETLSAE Mvan_1651|M.vanbaalenii_PYR-1 LKELGNRGIGVRLITGDHPVTAMVIAGELGLDVTAEQVMTGAEWEGLSAE MAB_0962|M.abscessus_ATCC_1997 LDYFASQHVSIKVISGDNAVSVSAVAQTLGLTG----AAVDARTLPTDTD : : :*:**: :. . **: . : . Mflv_0956|M.gilvum_PYR-GCK TLREQSPSFGVLARVAPEHKIRLVKALQSRGHVVAMTGDGVNDAPALKQA MSMEG_3926|M.smegmatis_MC2_155 DLQTVVQERDIFARASPEHKLRLVRALQAGGEVVAMTGDGVNDSPALKKA Rv0107c|M.tuberculosis_H37Rv AHAKLAADMQVFARVSPEQKVQIVAALQRCGRVTAMVGDGANDAAAIRMA Mb0111c|M.bovis_AF2122/97 AHAKLAADMQVFARVSPEQKVQIVASLQRCGRVTAMVGDGANDAAAIRMA MMAR_0297|M.marinum_M ACAKLAADVQVFARVSPEQKVQIVAALQRCGRVTAMVGDGANDAAAIRMA MUL_4826|M.ulcerans_Agy99 ACAKLAADVQVFARVSPEQKVQIVAALQRCGRVTAMVGDGANDAAAIRMA MAV_5219|M.avium_104 ACAKLVADVQVFARVSPEQKVQIVAALQRCGRVTAMVGDGANDAAAIRMA MLBr_02671|M.leprae_Br4923 ACAELAADVQVFARVSPEQKVQIVAALQRCGQVTAMVGDGANDAAAIRMA TH_2876|M.thermoresistible__bu ERAAAVRSRSVFARMSPEHKIDVVQTLERNGVVTAMVGDGANDAAAIRAA Mvan_1651|M.vanbaalenii_PYR-1 ERSEAVVSRIVYARMSPEHKIDVVQTLERIGMVTAMVGDGANDAAAIRAA MAB_0962|M.abscessus_ATCC_1997 KLAATLADATTFGRVRPDQKRAMVKALQSHGHTVAMTGDGVNDVLALKDA . .* *::* :* :*: * ..**.***.** *:: * Mflv_0956|M.gilvum_PYR-GCK DIGIAMGITGTDVSKGAANMILTDDNFGTIVAAVREGRGIYANIIKFVKF MSMEG_3926|M.smegmatis_MC2_155 DVGIAMGCRGTEAAKEAADMVLADDNFATIAAAVSEGRTVYDNIRKFVLF Rv0107c|M.tuberculosis_H37Rv DVGIGVSGRGSSAARGAADIVLTDDDLGVLLDALVEGRSMWAGVRDAVTI Mb0111c|M.bovis_AF2122/97 DVGIGVSGRGSSAARGAADIVLTDDDLGVLLDALVEGRSMWAGVRDAVTI MMAR_0297|M.marinum_M DVGIGVSGRGSSAARGAADIVLTDDDLGVLLDALVEGRSMWAGVRDAVTI MUL_4826|M.ulcerans_Agy99 DVGIGVSGRGSSAARGAADIVLTDDDLGVLLDALVEGRSMWAGVRDAVTI MAV_5219|M.avium_104 DVGIGVSGRGSSAARGAADIVLTDQDLSVLLDALVEGRSMWAGVRDAVTI MLBr_02671|M.leprae_Br4923 DVGIGVSGRGSSAARGAADIVLTDDDLGVLLDALVEGRSMWAGVRDAVTI TH_2876|M.thermoresistible__bu SVGVGVATRSSDPARTAADIVLLDGRIEALIDALDEGHHLWRRVQSAVSM Mvan_1651|M.vanbaalenii_PYR-1 SVGFGVASRGSDPARTAADVVLLDGRIEALLDALDEGKQLWRRVQSAVSM MAB_0962|M.abscessus_ATCC_1997 DIGVAMG-AGSSASRAVAQIVLLDNKFATLPYVVAEGRRVIGNIERVSNL .:*..:. .:. :: .*:::* * : .: .: **: : : : Mflv_0956|M.gilvum_PYR-GCK QLTTAWGFVLIFLVCGSLGLAGGAPFTALQILWVNIIMDGPPALALGVDP MSMEG_3926|M.smegmatis_MC2_155 MLPTNGGEALVVIAAILFQFT--LPLTPAQVLWINLVTSSTLGLALAFEP Rv0107c|M.tuberculosis_H37Rv LVGGNVGEVLFTVIGTAFGAG-RAPVGTRQLLLVNLLTDMFPALAVAVTS Mb0111c|M.bovis_AF2122/97 LVGGNVGEVLFTVIGTAFGAG-RAPVGTRQLLLVNLLTDMFPALAVAVTS MMAR_0297|M.marinum_M LVGGNVGEVLFTIIGTAFGAG-RAPVGTRQLLLVNLLTDMFPALAVAITS MUL_4826|M.ulcerans_Agy99 LVGGNVGEVLFTIIGTAFGAG-RAPVGTRQLLLVNLLTDMFPALAVAITS MAV_5219|M.avium_104 LVGGNVGEVLFTIIGTAFGAG-RAPVGTRQLLLVNLLTDMFPALAVAVTS MLBr_02671|M.leprae_Br4923 LVGGNVGEVVFTIIGTVFGAG-RAPVGTRQLLLVNLLTDMFPALSIAVTS TH_2876|M.thermoresistible__bu LLGGNSGEIAFALLTSLLTG--RSVLNARXXXTTAADAEPIPCKARAIPS Mvan_1651|M.vanbaalenii_PYR-1 LLGGNTGEIAFALITSLLTG--RSVLNARQMLLVNMLTDALPAAALAVSR MAB_0962|M.abscessus_ATCC_1997 FLTKTVYSVLLALTVGLAGLG-SKIFHYGAVPFPFQPIHVTIAAWFTIGI : . : . . Mflv_0956|M.gilvum_PYR-GCK TEPDVMHQKPRPPTERLLNRARLQR----ILVLGMVMTLGTVTVLMLADD MSMEG_3926|M.smegmatis_MC2_155 PEAGVMRRKPRAPSESLLSRHFAWR----VLLVSVLMAGGALGMFLWE-- Rv0107c|M.tuberculosis_H37Rv QFAEPDDAEYPTDDAAERAQREHRR----AVLIGPTPSLDAPLLRQIVNR Mb0111c|M.bovis_AF2122/97 QFAEPDDAEYPTDDAAERAQREHRR----AVLIGPTPSLDAPLLRQIVNR MMAR_0297|M.marinum_M QYDDPEDDSDLSDEEIEEARRRRQR----AVLTAPTPSLDAPLMRQIANR MUL_4826|M.ulcerans_Agy99 QYDDPEDDSDLSDEEIEEARRRRQR----AVLTAPTPSLDAPLMRQIANR MAV_5219|M.avium_104 QYVEPDEAEYPSAADAEAARREHRR----AVLTGPTPSLDAPLMRQIVTR MLBr_02671|M.leprae_Br4923 QYEEPGEDEYQTDEEADEARRTHQH----EVLTGPTPSLDAPLMRQIVNR TH_2876|M.thermoresistible__bu MVMSGATAHSTDASMCTAIPAISGRRRPNESDRGPTTSWPSASPTSVPVN Mvan_1651|M.vanbaalenii_PYR-1 QTDTTGQVDLDEAAMWRAIGVRG-----AATTVGATSAWAMASMTGTPQR MAB_0962|M.abscessus_ATCC_1997 PAFILSLAPNNERAQTGFVRRVMLS----AIPSGLTVGIATFLSYLLARQ . Mflv_0956|M.gilvum_PYR-GCK L-------FPESAGDPLFATTLAFTTFVFYQVFNLLNVRSDTGSAFSRQ- MSMEG_3926|M.smegmatis_MC2_155 ---------LRSGTSVETARTMAVNAIVAAEMFYLLNNRFLLEPVLNRIG Rv0107c|M.tuberculosis_H37Rv G------VVTAAGATAAWAIGRWTPGTERRTATMGLTALVMTQLAQTLLT Mb0111c|M.bovis_AF2122/97 G------VVTAAGATAAWAIGRWTPGTERRTATMGLTALVMTQLAQTLLT MMAR_0297|M.marinum_M G------VVTAAGATAAWAIGRWTPGTERRTATMGLTALVTTQLAQTLLT MUL_4826|M.ulcerans_Agy99 G------VVTAAGATAAWAIGRWTPGTERRTATMGLTALVTTQLAQTLLT MAV_5219|M.avium_104 G------AVTAAGATAAWAIGRWTPGTERRTATMGLTALVTTQLAQTLLT MLBr_02671|M.leprae_Br4923 G------VVTAAGATTAWAIGRWTPGTERRTATMGLTALVTTQLAQTLLT TH_2876|M.thermoresistible__bu VSCATDDDTFSSSAIRGSAGRYMSMVSGPRVISAPSIRIMRVRLGIPLGV Mvan_1651|M.vanbaalenii_PYR-1 A---------STVALIG----LVSTQLAQTLIDSRSPLVVATALGS---- MAB_0962|M.abscessus_ATCC_1997 I---------------LHVSGNSTQASTAALITELVAAVWVLAVVARPYQ Mflv_0956|M.gilvum_PYR-GCK TFTNGAIWVSLAAVIVLQVLVVQLDVLQNLFDTTELT---------SAQW MSMEG_3926|M.smegmatis_MC2_155 LFGNKIAFATVVACTALQLVFTYAPAMNAVFGSTPLG---------YVDW Rv0107c|M.tuberculosis_H37Rv RRHSPLVIATALGSAGVLVGIIQTPVISHFSGVPRWDR--------SPGR Mb0111c|M.bovis_AF2122/97 RRHSPLVIATALGSAGVLVGIIQTPVISHFFGCTPLG---------PVAW MMAR_0297|M.marinum_M RSHSPLVLATAFGSAGVLIGIIQTPVVSHFFGCTPLG---------PVAW MUL_4826|M.ulcerans_Agy99 RSHSPLVLATAFGSAGVLIGIIQTPVVSHFFGCTPLG---------PVAW MAV_5219|M.avium_104 RRHSPLVVATALGSAGVLVGIVQTPVLSQFFGCTPLG---------PVAW MLBr_02671|M.leprae_Br4923 RRHSPLVVATALGSAGVLIGIIQTPVISQFFGCTPLG---------PIAW TH_2876|M.thermoresistible__bu RGDVRSERATAFDSATEVLSDANHLFCSRTRGFGARVVAHIGGTRQALAW Mvan_1651|M.vanbaalenii_PYR-1 -----------FATLAGVISTP-----GVSQVFGCTPVGPVG-------W MAB_0962|M.abscessus_ATCC_1997 WWRVALVALSGLGYVAIFAIPLARKAFMLDPGNLAVTG---------PAL Mflv_0956|M.gilvum_PYR-GCK LFAIAVGSSVLVVDEIGK-------------------------------- MSMEG_3926|M.smegmatis_MC2_155 IKAAAVGAPVFGVVELEK-------------------------------- Rv0107c|M.tuberculosis_H37Rv ASSAPRQEPPQSQRWHRS-------------------------------- Mb0111c|M.bovis_AF2122/97 TGVFSATAGATAVSALAP-------------------------------- MMAR_0297|M.marinum_M TGVFSATAGATAVSVLAP-------------------------------- MUL_4826|M.ulcerans_Agy99 TGVFSATAGATAVSALAP-------------------------------- MAV_5219|M.avium_104 TGVLGSTAGATAISALAP-------------------------------- MLBr_02671|M.leprae_Br4923 SGVITATAGATAVSVLAP-------------------------------- TH_2876|M.thermoresistible__bu AQPLRHREAAAHERMVPREGPVGRDTRHSIRWGVRWGVRWGARSGGGGAG Mvan_1651|M.vanbaalenii_PYR-1 GQAFSATAVAALLSATAPELLN---------------------------- MAB_0962|M.abscessus_ATCC_1997 GIGIAAAAVIEAVWWLQG-------------------------------- Mflv_0956|M.gilvum_PYR-GCK -----------------AVVRTARRRRRRRVSGADRPREARPASGR---- MSMEG_3926|M.smegmatis_MC2_155 -----------------FMVR---RRKARAALAGEEPKGGHTAAHR---- Rv0107c|M.tuberculosis_H37Rv --------------------GWQAQSVSCNLMNALTTRKTLTRVDRTYRR Mb0111c|M.bovis_AF2122/97 --------------------KWLASTVGVVQPDERPDDAEDSDAGG---- MMAR_0297|M.marinum_M --------------------KWLAKTVDVALEHQDWASGSA--------- MUL_4826|M.ulcerans_Agy99 --------------------KWLAKTVDVALEHQDWASGSA--------- MAV_5219|M.avium_104 --------------------NWLAKQVAALEPGQQDA------------- MLBr_02671|M.leprae_Br4923 --------------------QWLNKAFGIAQLNQE--------------- TH_2876|M.thermoresistible__bu ADRDHRTRLPGAGPRGARLRRPVAQQVPRRLPGQDRHQAGETLSGDRGGQ Mvan_1651|M.vanbaalenii_PYR-1 --------------RATDAVRKRVADVVESVPVVDDDDAGLDEDGVEGAD MAB_0962|M.abscessus_ATCC_1997 --------------------KWSGQPRHFWATGDD--------------- Mflv_0956|M.gilvum_PYR-GCK ------------------------ MSMEG_3926|M.smegmatis_MC2_155 ------------------------ Rv0107c|M.tuberculosis_H37Rv PR---------------------- Mb0111c|M.bovis_AF2122/97 ------------------------ MMAR_0297|M.marinum_M ------------------------ MUL_4826|M.ulcerans_Agy99 ------------------------ MAV_5219|M.avium_104 ------------------------ MLBr_02671|M.leprae_Br4923 ------------------------ TH_2876|M.thermoresistible__bu RGGGRFHRRRAGRGHIGRALGGDR Mvan_1651|M.vanbaalenii_PYR-1 R------RRQQ------MDTGGD- MAB_0962|M.abscessus_ATCC_1997 ------------------------