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MRDAAPRRAPTRRPRSSPPPPPPPPRRPQAARPEMSDAAVVSRSWGMALATLVSRLTGFARIVLLAAILG AALSSAFTVANQLPNMIAALVLEATFTAIFVPVLARAERDDPDGGAAFIRRLLTLATTLLLVVTIISTVA APLLVDLMLGPDPLVDRPLTTAFAYLLLPQIIFYGLSSVFMAILNTRNVFGPPAWAPVVNNVVAILTLGL YVLVPGELSLNPVQMGDAKLLVLGVGTTLGVVAQAGVLFMAIRRQRVSLRPLWGIDARLKKFGMMAVAMV LYVLISQVGFIVGNQVASTAAASGPAIYNYTWLILQLPFGIVGVTVLTVVMPRLSRNAAADDAPAVLADL SLATRLTMITLIPIVAMMTVGGPAIGSALFSYGNFGAVDAGYLGMAITLSAFTLIPYTLVLLQLRVFYAR EEPWTPILLIIVITIVKIAASLAAPHLTADPQLVAGYLGLANGLGFLAGATVGYLLLRARLDPPGGRLLD NAVIRTILVTITASLAAGLTAHVVDQLAGLENLTTHWGAAGSLLRLLALGLVMVPIIAAVMLTAKVPEAQ AALAAVRRRLGTRGPAAEPSVRPRPSDTLTYPDHKNRSSLRRRQLPRSAARGPSAEAADDGRRKGFAVSD KPTSGSPGGPDSAATTRITRPSPDDFQPDVPEDAGTHVLPQAPARPTGPESAARPTGPESAARPAGPESA ARPPVSDYAGDPTREALPFDPPREPATEAATTAEDMHLIPGATIVDGRYRLLVSHGGPAHLQFWQALDTA LDRQVALTFVDPDATMPDRAVQEILDRTQRLSRIDMPGVARVLDVVSTGVGGLVVSEWIRGGSLAEVADT CPSPIGGARAIQSLAAAAEVAHRNGVALSIDHPSRIRVSIDGDVALAFPATLPDASPDDDIRGIGASLYA LLVNRWPLPETGEPSGLAPADLDAAGQPVEPRSVDRDIPFQISAAAAHAVQEGGGIRSAPTLLNLLQQAT AIADRTDHIAPVDDPAPPPSGAGFAAELDPEAAARRRKGLIVGLSVAGAIAVIAVVLLATVLSRIFGDVG DGLGGDELGLNSPSSSTTAQPGQSGSALKPVSVTVFSPEGEADAPKLAGLAIDGNPATVWPIDTYTDAAP FPNFKNGVGLMLQLPEPAKIGSVTVNLNSTGTSVQIRSSETATPSSLEDTTALTDPTPVKPGSNTIEVED AEPTSYVLVWISTLGQVDGESRSDIAEVTLNAAS
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. vanbaalenii PYR-1 | Mvan_6064 | - | - | 100% (1224) | integral membrane protein MviN |
M. vanbaalenii PYR-1 | Mvan_3539 | - | 7e-08 | 30.26% (152) | protein kinase |
M. vanbaalenii PYR-1 | Mvan_5401 | - | 8e-07 | 23.37% (338) | protein kinase |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb3940 | - | 0.0 | 64.86% (1215) | transmembrane protein |
M. gilvum PYR-GCK | Mflv_0842 | - | 0.0 | 79.77% (1221) | integral membrane protein MviN |
M. tuberculosis H37Rv | Rv3910 | - | 0.0 | 64.86% (1215) | transmembrane protein |
M. leprae Br4923 | MLBr_02700 | - | 0.0 | 60.48% (1212) | hypothetical protein MLBr_02700 |
M. abscessus ATCC 19977 | MAB_4937 | - | 0.0 | 51.51% (1225) | hypothetical protein MAB_4937 |
M. marinum M | MMAR_5474 | - | 0.0 | 65.65% (1208) | transmembrane protein |
M. avium 104 | MAV_5298 | - | 0.0 | 63.41% (1238) | virulence factor mvin family protein |
M. smegmatis MC2 155 | MSMEG_6929 | - | 0.0 | 69.98% (1236) | integral membrane protein MviN, putative |
M. thermoresistible (build 8) | TH_2415 | - | 0.0 | 65.02% (626) | PROBABLE CONSERVED TRANSMEMBRANE PROTEIN |
M. ulcerans Agy99 | MUL_5063 | - | 0.0 | 64.86% (1218) | transmembrane protein |
CLUSTAL 2.0.9 multiple sequence alignment Mvan_6064|M.vanbaalenii_PYR-1 ------------MRDAAPRRAPTRRPRSSPPPPPPPPRRPQAARPEMSDA Mflv_0842|M.gilvum_PYR-GCK ---------------------------------------MPDARPEMSDR TH_2415|M.thermoresistible__bu -------------------------------------------------- MSMEG_6929|M.smegmatis_MC2_155 -----------------MNATQPQRPPGPRRLPRGPAPRRRAGQEELSDA Mb3940|M.bovis_AF2122/97 -------------------------MRPSPGEVPTASQ----RQPELSDA Rv3910|M.tuberculosis_H37Rv -------------------------MRPSPGEVPTASQ----RQPELSDA MMAR_5474|M.marinum_M ---------------------------MPYGQAAAGPP----KRAELSDA MUL_5063|M.ulcerans_Agy99 ---------------------------MPYGPAAAGPP----KRAELSDA MAV_5298|M.avium_104 MNPAYRQAAPHHRRLPEPPRRPRMPGSPPTGPLPPVPAGIDRRRPELSDS MLBr_02700|M.leprae_Br4923 --------------MKPAPRWTQSQSAQQVTHAMRPCRELSAQQPELSDA MAB_4937|M.abscessus_ATCC_1997 ---------------------------MREPLDPLPDPEADDTIEELSDA Mvan_6064|M.vanbaalenii_PYR-1 AVVSRSWGMALATLVSRLTGFARIVLLAAILGAALSSAFTVANQLPNMIA Mflv_0842|M.gilvum_PYR-GCK AVVSRSWGMAVATLVSRLTGFARIVLLAAILGAALSSAFTVANQLPNMIA TH_2415|M.thermoresistible__bu -------------------------------------------------- MSMEG_6929|M.smegmatis_MC2_155 AVVSRSWGMAMATLISRITGFIRIVLLAAILGAALSSAFSVANQLPNLIA Mb3940|M.bovis_AF2122/97 ALVSHSWAMAFATLISRITGFARIVLLAAILGAALASSFSVANQLPNLVA Rv3910|M.tuberculosis_H37Rv ALVSHSWAMAFATLISRITGFARIVLLAAILGAALASSFSVANQLPNLVA MMAR_5474|M.marinum_M ALVSRSWGMALATLVSRITGFARIVLLAAILGAALSSSFSVANQLPNLVA MUL_5063|M.ulcerans_Agy99 ALVSRSWGMALATLVSRITGFARIVLLAAILGAALSSSFSVANQLPNLVA MAV_5298|M.avium_104 ALVSRSWAMAFATLVSRLTGFARVVLLAAILGAALSSAFSVANQLPNLVA MLBr_02700|M.leprae_Br4923 ALVSRSWAMAFATLISRITGFARVVLLAAILGAALSSAFSVANQLPNLVA MAB_4937|M.abscessus_ATCC_1997 AVVSHSGSMAVATLVSRITGFIKLLLITAALGAASASAFSTANTLPNIIA Mvan_6064|M.vanbaalenii_PYR-1 ALVLEATFTAIFVPVLARAERDDPDGGAAFIRRLLTLATTLLLVVTIIST Mflv_0842|M.gilvum_PYR-GCK ALVLEATFTAIFVPVLARAERDDPDGGAAFIRRLLTLATALLLAVTIIST TH_2415|M.thermoresistible__bu -------------------------------------------------- MSMEG_6929|M.smegmatis_MC2_155 ALVLEATFTAIFVPVLARAERDDPDGGAAFVRRLVTLVTTLLLVTTLVSV Mb3940|M.bovis_AF2122/97 ALVLEATFTAIFVPVLARAEQDDPDGGAAFVRRLVTLATTLLLGATTLSV Rv3910|M.tuberculosis_H37Rv ALVLEATFTAIFVPVLARAEQDDPDGGAAFVRRLVTLATTLLLGATTLSV MMAR_5474|M.marinum_M ALVLEATFTAIFVPVLARAEQDDPDGGAAFVRRLVTLTTTLLIVATTLSV MUL_5063|M.ulcerans_Agy99 ALVLEATFTAIFVPVLARAEQDDPDGGAAFVRRLVTLTTALLIVATTLSV MAV_5298|M.avium_104 ALVLEATFTAIFVPVLARAEQSDPDGGAAFVRRLVTLTTALLIVATALSV MLBr_02700|M.leprae_Br4923 ALVLEATFTAIFVPVLVRAERSDPDGGTAFVRQLITLTTTLLLLSTTLSV MAB_4937|M.abscessus_ATCC_1997 ALVLEATFTAIFIPVLTRAEREDADGGEAFIRKLLTIVTTLLLVTTLLSV Mvan_6064|M.vanbaalenii_PYR-1 VAAPLLVDLMLGPDPLVDRPLTTAFAYLLLPQIIFYGLSSVFMAILNTRN Mflv_0842|M.gilvum_PYR-GCK VGAPLLVNLMLGSEPLVNQPLTTAFAFLLLPQIIFYGLSSVFMAILNTRN TH_2415|M.thermoresistible__bu -------------------------------------------------- MSMEG_6929|M.smegmatis_MC2_155 AAAPALVRLMLGDDPQVNEPLTTAFAYLLLPQVLFYGLSSVFMAILNTRN Mb3940|M.bovis_AF2122/97 LAAPLLVRLMLGTNPQVNEPLTTAFAYLLLPQVLVYGLSSVFMAILNTRN Rv3910|M.tuberculosis_H37Rv LAAPLLVRLMLGTNPQVNEPLTTAFAYLLLPQVLVYGLSSVFMAILNTRN MMAR_5474|M.marinum_M LAAPLLVRLMLGRDPQVNEPLTTAFAYLLLPQVLVYGLSSVFMAILNTRN MUL_5063|M.ulcerans_Agy99 LAAPLLVRLMLGRDPQVNEPLTTAFAYLLLPQVLVYGLSSVFIAILNTRN MAV_5298|M.avium_104 AAAPLLVRLMLGRTPQVNEPLTVAFAYLLLPQVLAYGLTSVFMAILNTRN MLBr_02700|M.leprae_Br4923 LAAPLLVRLMLGRNPQVNEPLTTAFAYLLLPQVLAYGLSSVFMAILNTRN MAB_4937|M.abscessus_ATCC_1997 LAAPLLAGIMLGGDPKVNTPLTTALAYLLLPQVFFYGLSSLFMAILNTRN Mvan_6064|M.vanbaalenii_PYR-1 VFGPPAWAPVVNNVVAILTLGLYVLVPGELSLNPVQMGDAKLLVLGVGTT Mflv_0842|M.gilvum_PYR-GCK IFGPPAWAPVVNNVVAIATLGLYVLVPGELSLDPVRMGDAKLLVLGIGTT TH_2415|M.thermoresistible__bu -------------------------------------------------- MSMEG_6929|M.smegmatis_MC2_155 VFGPPAWAPVLNNVVAIATLGAYLLVPGELSVDPVQMGNAKLLVLGVGTT Mb3940|M.bovis_AF2122/97 VFGPPAWAPVVNNVVAIATLAVYLAVPGELSVDPVRMGNAKLLVLGIGTT Rv3910|M.tuberculosis_H37Rv VFGPPAWAPVVNNVVAIATLAVYLAVPGELSVDPVRMGNAKLLVLGIGTT MMAR_5474|M.marinum_M VFGPPAWAPVINNVVAIATLLVYLAVPGELAIDPVKMGNAKLLVLGVGTT MUL_5063|M.ulcerans_Agy99 VFGPPAWAPVINNGVAIATLLVYLAVPGELAVDPVKMGNAKLLVLGVGTT MAV_5298|M.avium_104 VFGPTAWAPVVNNVVALATLAVYALVPGELSVDPVRMGNAKLLVLAVGTT MLBr_02700|M.leprae_Br4923 VFGPPAWAPVINNIVAIAALVGYLVTPGELSVDPVRMGNAKLLVLGIGTT MAB_4937|M.abscessus_ATCC_1997 VFGPPAWAPVWNNLVAIATLVLYWLMPGELTLDPIRMSDPKLLVLGIGTT Mvan_6064|M.vanbaalenii_PYR-1 LGVVAQAGVLFMAIRRQRVSLRPLWGIDARLKKFGMMAVAMVLYVLISQV Mflv_0842|M.gilvum_PYR-GCK LGVVAQAAVLFVAIRRERISLRPLWGIDARLKKFGMMALAMVLYVLVSQV TH_2415|M.thermoresistible__bu -------------------------------------------------- MSMEG_6929|M.smegmatis_MC2_155 LGVVAQCSVLLPAIRRERISLRPLWGIDDRLKKFGAMAAAMVLYVLISQI Mb3940|M.bovis_AF2122/97 AGVFAQTAVLLVAIRREHISLRPLWGIDQRLKRFGAMAAAMVLYVLISQL Rv3910|M.tuberculosis_H37Rv AGVFAQTAVLLVAIRREHISLRPLWGIDQRLKRFGAMAAAMVLYVLISQL MMAR_5474|M.marinum_M LGVFAQAAVLLVAIGRQHISLRPLWGIDDRLKRFGAMAAAMVLYVLISQL MUL_5063|M.ulcerans_Agy99 LGVFAQAAVLLVAIGRQHISLRPLWGIDDRLKRFGAMAAAMVLYVLVSQL MAV_5298|M.avium_104 LGVFAQTGVLLVALRRQHVDLRPLWGIDQRLKRFGTLAAAMVLYVLISQL MLBr_02700|M.leprae_Br4923 AGAFAQTAVLLVALGREHISLHPLWGLDQRLKRFGAMATAMVLYVLISQL MAB_4937|M.abscessus_ATCC_1997 LGVAAQAMVLLPAIRRQQIPLRPLWGLDDRLKQFGGMAAAMFAYVAISQF Mvan_6064|M.vanbaalenii_PYR-1 GFIVGNQVASTAAASGPAIYNYTWLILQLPFGIVGVTVLTVVMPRLSRNA Mflv_0842|M.gilvum_PYR-GCK GFIVGNQVASASAASGPAIYNYTWLILQLPFGIVGVTVLTVVMPRLSRNA TH_2415|M.thermoresistible__bu -------------------------------------------------- MSMEG_6929|M.smegmatis_MC2_155 GLVVGNQIASGAAASGPAIYNYAWLVLQLPFGMIGVTVLTVVMPRLSRNA Mb3940|M.bovis_AF2122/97 GLVVGNRIASTAAASGPAIYNYTWLVLMLPFGMIGVTVLTVVMPRLSRNA Rv3910|M.tuberculosis_H37Rv GLVVGNRIASTAAASGPAIYNYTWLVLMLPFGMIGVTVLTVVMPRLSRNA MMAR_5474|M.marinum_M GLIVGNQIASGAAASGPAIYNYTWLVLMLPFGMIGVTVLTVVMPRLSRNA MUL_5063|M.ulcerans_Agy99 GLIVGNQIASGAAASGPAIYNYTWLVLMLPFGMIGVTVLTVVMPRLSRNA MAV_5298|M.avium_104 GLVVGNQIASTAAASGPAIYNYTWLVLMLPFGMIGVTVLTVVMPRLSRNA MLBr_02700|M.leprae_Br4923 GLVVTNQIASTTAASGPAIYNYTWLVLMLPFGIIGVTVLTVVMPRLSRNA MAB_4937|M.abscessus_ATCC_1997 GYVIANRIAAGAAESGPIIYSQTWMILQLPYGVVGVTILTAIMPRLSRNA Mvan_6064|M.vanbaalenii_PYR-1 AADDAPAVLADLSLATRLTMITLIPIVAMMTVGGPAIGSALFSYGNFGAV Mflv_0842|M.gilvum_PYR-GCK ASGDGGAVLADLSLATRLTMLTLIPIVALMTVGGPAIGSALFSYGNFGAV TH_2415|M.thermoresistible__bu -------------------------------------------------- MSMEG_6929|M.smegmatis_MC2_155 AKNDIPAVLGDLSLATRLTMITLIPIVALMTVGGPAIGTALFAYGNFGRV Mb3940|M.bovis_AF2122/97 AADDTPAVLADLSLATRLTMITLIPTVAFMTVGGPAIGSALFAYGNFGDV Rv3910|M.tuberculosis_H37Rv AADDTPAVLADLSLATRLTMITLIPTVAFMTVGGPAIGSALFAYGNFGDV MMAR_5474|M.marinum_M AAEDIPAVLADLSLATRLTMITLIPTVAFMTVGGSAMGSALFAYGNFGKV MUL_5063|M.ulcerans_Agy99 AAEDILAVLADLSLATRLTMITLIPTVAFMTVGGSAMGSALFAYGNFGKV MAV_5298|M.avium_104 AADDTRAVLADLSLATRLTLITLIPIVAFMTVGGPAMGSALFAYGHFGDV MLBr_02700|M.leprae_Br4923 AANDTPAMLADLSLATRLTLITLIPTVAFMTAGGSAMGSVLFAYGHFGEV MAB_4937|M.abscessus_ATCC_1997 AAQDTPAVLGDMSLATRLTMTVLIPVVAVMTVAGPAMGPALFAYGNFHLG Mvan_6064|M.vanbaalenii_PYR-1 DAGYLGMAITLSAFTLIPYTLVLLQLRVFYAREEPWTPILLIIVITIVKI Mflv_0842|M.gilvum_PYR-GCK DAGYLGMAITLSAFTLIPYTMVLLQLRVFYAREEPWTPIVLIVVITIVKI TH_2415|M.thermoresistible__bu -------------------------------------------------- MSMEG_6929|M.smegmatis_MC2_155 DAGYLGLAISLSAFTLIPYALVLLQLRVFYARERAWTPIIVIIVITVVKI Mb3940|M.bovis_AF2122/97 DAGYLGAAIALSAFTLIPYALVLLQLRVFYAREQPWTPITIIVVITGVKI Rv3910|M.tuberculosis_H37Rv DAGYLGAAIALSAFTLIPYALVLLQLRVFYAREQPWTPITIIVVITGVKI MMAR_5474|M.marinum_M DAGYLGAAIALSAFTLIPYALVLLGLRVFYAREQPWTPILIIIIITSVKI MUL_5063|M.ulcerans_Agy99 DAGYLGAAIALSAFTLIPYALVLLGLRVFYAREQPWTPILIIIIITSVKI MAV_5298|M.avium_104 DAGYLGAAIALSAFTLIPYGLVLLQLRVFYAREQPWTPIVIILVITAVKI MLBr_02700|M.leprae_Br4923 DAGYLGTAIVLSAFTLIPYGLVLLQLRVFYAREQPWTPIVIIVVITAVRI MAB_4937|M.abscessus_ATCC_1997 SAHYLGLSISLSAFTLIPYALVLLQLRVFYARHEAWTPTLMIIVITAVKV Mvan_6064|M.vanbaalenii_PYR-1 AASLAAPHLTADPQLVAGYLGLANGLGFLAGATVGYLLLRARLDPPGGRL Mflv_0842|M.gilvum_PYR-GCK AASLASPHLTDDPQLVAGYLGLANGLGFLAGATVGYLLLRARLDPPGGHL TH_2415|M.thermoresistible__bu --------VTDDP---------ATGAAPTPDRTT-----TTRLPRPSAAE MSMEG_6929|M.smegmatis_MC2_155 AGSVAAPHLTNNPEMVAGYLGAANGLGFMAGAIVGHVLLRANLDPPGGRL Mb3940|M.bovis_AF2122/97 LGSLLAPHITGDPQLVAAYLGLANGLGFLAGTIVGYYILRRALRPDGGQL Rv3910|M.tuberculosis_H37Rv LGSLLAPHITGDPQLVAAYLGLANGLGFLAGTIVGYYILRRALRPDGGQL MMAR_5474|M.marinum_M GASVLAPHLTNDPDMVAGYLGLANGLGFLAGAIVGYYLLRRALRPGGGQL MUL_5063|M.ulcerans_Agy99 GASVLAPHLTNDPDMVAGYLGLANGLGFLAGAIVGYYLLRRALCPGGGQL MAV_5298|M.avium_104 LGSVLAPHLTGDPKLVAGFLGLANGVGFLAGAVIGYVLLRRTLLPGGGHL MLBr_02700|M.leprae_Br4923 IVSVLAPYVISNPELVAGYLGMANGLGFAAGAIVGYYLLRRALLPTGGHL MAB_4937|M.abscessus_ATCC_1997 IGSVAAPHLTDDPDLVAGYLGAANGLGFVAGALCGYLLLRRSLGRAAGPL : :* *.* . .. * .. Mvan_6064|M.vanbaalenii_PYR-1 LDNAVIRTILVTITASLAAGLTAHVVDQLAGLENLTTHWGAAGSLLRLLA Mflv_0842|M.gilvum_PYR-GCK VSRDVVRTILVTITASLAAGLIAHIADQILGLEQLTEHWGGGGSLIRLAV TH_2415|M.thermoresistible__bu SSR----------SASLAG------------------------------- MSMEG_6929|M.smegmatis_MC2_155 VSLTVVRTILVTITASLLAVLVSVVVDQLLGVEQLTVRFGAGGSMIRLVV Mb3940|M.bovis_AF2122/97 IGVGEARTALVTVAASLLAGLLAHVADRLLGLSELTAHAGSVGSLLRLSV Rv3910|M.tuberculosis_H37Rv IGVGEARTVLVTVAASLLAGLLAHVADRLLGLSELTAHAGSVGSLLRLSV MMAR_5474|M.marinum_M VGTREVHTILVTIAASLLAGLLAYVVDRLAGLGQLTVFGGGIGSLLRLLI MUL_5063|M.ulcerans_Agy99 VGTREVHTILVTIAASLLAGLLAYVVDRLAGLGQLTVFDGGIGSLLRLLI MAV_5298|M.avium_104 IGVGEVRTILVTLTAAMLAGLVAHVADRLLGLSALTAHGGGAGSLLRLLV MLBr_02700|M.leprae_Br4923 FGVQEIRTVLVTIAASLLAGLAAHIADRLLRLNELTMHGGGAGSLLRLTV MAB_4937|M.abscessus_ATCC_1997 IGPDVARTALVALAASVTAAAVGLGIDRGFGLDLLTQRGGGLGSILRLAI . :*:: . Mvan_6064|M.vanbaalenii_PYR-1 LGLVMVPIIAAVMLTAKVPEAQAALAAVRRRLGTRGPAAEPSVRPRPSDT Mflv_0842|M.gilvum_PYR-GCK LGLVMGPIILGVLIAAKVPDALAGVAAVRRRLGARGATTGSPVPQMSPRA TH_2415|M.thermoresistible__bu -------------------------------------EARPSADDFEPDV MSMEG_6929|M.smegmatis_MC2_155 LGLIMLPIIAGVLIAAKVPEAQAAIRVVRGRLGRFGGKETPAVDAAEKVA Mb3940|M.bovis_AF2122/97 LALIMLPILAAVTLCARVPEARAALDAVRARIRSRRLKTGPQTQNVLDQS Rv3910|M.tuberculosis_H37Rv LALIMLPILAAVTLCARVPEARAALDAVRARIRSRRLKTGPQTQNVLDQS MMAR_5474|M.marinum_M LGVIMAPIVIAVLLAGQVPEAQAALNVVRNRIGTRLGKPGPRSVAVPDAS MUL_5063|M.ulcerans_Agy99 LGVIMAPIVIAVLLAGQVPEAQAALNVVRNRIGTRLGKPGPRSVAVLDPS MAV_5298|M.avium_104 LALIMVPITAAVMLRAQVPEARAALDAVRFRITGR--GPRPRKPAAPDRS MLBr_02700|M.leprae_Br4923 LTSIMLPTMAVVMLRGHVPEVHAALGAVRGQIMSRNWIAKLQKATVPDQS MAB_4937|M.abscessus_ATCC_1997 LGIVMLAVTFALMVAVKLPEALSVVAMLQRRLGGR-LGARLRAETQDHAS Mvan_6064|M.vanbaalenii_PYR-1 LTYPDHKNRSSLRRRQLPRSAARGPSAEAADDGRRKGFAVSDKPTSGSPG Mflv_0842|M.gilvum_PYR-GCK LTYADRSNR-------------RGPSAETADDGRRKGSAVSDKPTSDSPS TH_2415|M.thermoresistible__bu LEAD-------------------GGGAHPAD------------------- MSMEG_6929|M.smegmatis_MC2_155 LQTNGPAVPPR-----------TAGAVTYPDQRNSSPGRGPTTPAPGWVG Mb3940|M.bovis_AF2122/97 SRPG--------------------PVTYPERRRLAPPRGKSVVHEPIRRR Rv3910|M.tuberculosis_H37Rv SRPG--------------------PVTYPERRRLAPPRGKSVVHEPIRRR MMAR_5474|M.marinum_M SGDH--------------------DVTYPEQRKSSLP-GENVVQEPIRRK MUL_5063|M.ulcerans_Agy99 SGDH--------------------DVTYPEQRKSSLP-GENVVQEPIRRK MAV_5298|M.avium_104 SHRR--------------------PVTYPEQRNSSPP-GVNAVQEPIRRR MLBr_02700|M.leprae_Br4923 SRPI--------------------TVTYPGQNNSSPP-RVNAIQESIRSR MAB_4937|M.abscessus_ATCC_1997 VMGN---------------------------------------------- Mvan_6064|M.vanbaalenii_PYR-1 GPDSAATTR----------------------ITRPSPDDFQPDVPEDAGT Mflv_0842|M.gilvum_PYR-GCK GPDSTAPPSGPNSTAPPSGPNSTAPPSGPNSTAPPSADDFQPDVPDSYQP TH_2415|M.thermoresistible__bu GP---------------------------------------PEVAG---- MSMEG_6929|M.smegmatis_MC2_155 APASVAGAG----------------TRKGSPVTDESAGGPALDGTATTKL Mb3940|M.bovis_AF2122/97 PPEQVARAG---------------------RAKGPEVIDRPSE-NASFG- Rv3910|M.tuberculosis_H37Rv PPEQVARAG---------------------RAKGPEVIDRPSE-NASFG- MMAR_5474|M.marinum_M PP--VIRAG---------------------IAKGPSVTDRPSDSTASSS- MUL_5063|M.ulcerans_Agy99 PP--VIRAG---------------------IAKGPSVTDRPSDSTASSS- MAV_5298|M.avium_104 PPERANRAR---------------------LVKGPEVTDRPMESAASSAG MLBr_02700|M.leprae_Br4923 PPERIAKAQ---------------------IAKGPEVSDRPVESASSRSA MAB_4937|M.abscessus_ATCC_1997 -------------------------------------------------- Mvan_6064|M.vanbaalenii_PYR-1 HVLPQAPARPTGPESAARPTGPESAARPAG--PESAARPPVSDYAGDPTR Mflv_0842|M.gilvum_PYR-GCK DPAADDSATTALP-AQGVPTQSPSKSPTET--PTEAVKRPRADYSNDPTR TH_2415|M.thermoresistible__bu ---ATESVDRRAIDRRAIDTGTAATTETAR--PVMSGRPP-ADYGGDPSR MSMEG_6929|M.smegmatis_MC2_155 PRQAPDDFQPDVADDESEAAGAEPTVEETVSLPNGSGRPP-ADYGGDPTR Mb3940|M.bovis_AF2122/97 AASGA--ELPRPVADELQLDAPAG-RDPGPVSRPHPSDLQNGDLPADAAR Rv3910|M.tuberculosis_H37Rv AASGA--ELPRPVADELQLDAPAG-RDPGPVSRPHPSDLQNGDLPADAAR MMAR_5474|M.marinum_M SASDI--DLPRPVADDFQPDIPAG-PDRGRGASQRPSDQSNGDS-VGYTR MUL_5063|M.ulcerans_Agy99 SASDI--DLPRPVADDFQPDIPAG-PDRGRGASLRPSDLSNGDS-VGYTR MAV_5298|M.avium_104 PGTGS--GAPRPVADDFQPDIPADQPDRPRKADPRPADQKNGDA--GTRR MLBr_02700|M.leprae_Br4923 SDTGLPSELPRPVAGNSQPYISAN-LELEHVASLHPPEQQKVDFPAYPAR MAB_4937|M.abscessus_ATCC_1997 ---SPGPSLPYPDSGDPVGGSDAIGSTTAN----KPAHGGGADTRKGRAV . * Mvan_6064|M.vanbaalenii_PYR-1 EALPFDPPR-EPATEAATTAEDMHLIPGATIVDGRYRLLVSHGGPAHLQF Mflv_0842|M.gilvum_PYR-GCK EALAFDPPR-EPAIETATPAEDTHLIPGATIAGGRYRLLVSHGGPEHLQF TH_2415|M.thermoresistible__bu EPLAFDYPR-EPAIEAATAEEDVHLIPGATVGGGRYRLLVFHGGPEHLQF MSMEG_6929|M.smegmatis_MC2_155 EPISFAPPR-EPAVESATSGDDVHLIPGATIADGRYRLLVFHGGPPHLQF Mb3940|M.bovis_AF2122/97 GPIAFDALR-EPDRESSAPPDDVQLVPGARIANGRYRLLIFHGGVPPLQF Rv3910|M.tuberculosis_H37Rv GPIAFDALR-EPDRESSAPPDDVQLVPGARIANGRYRLLIFHGGVPPLQF MMAR_5474|M.marinum_M GPIPFDAPR-ERSAEPSTPQDDVNLVPGARIANGRYRLLVFHGGIPPLQF MUL_5063|M.ulcerans_Agy99 GPIPFDAPR-ECSAEPSTPQDDVNLVPGARIANGRYRLLVFHGGIPPLQF MAV_5298|M.avium_104 G--PFDVPR-ERAADSSA--DDVHLVPGARIAGGRYRLLVFHGGAPPLQF MLBr_02700|M.leprae_Br4923 RPIRFEVSR-ERGGEQSSPTGDVHLVPGACIAGGRYRLLAFHGGAPSLQF MAB_4937|M.abscessus_ATCC_1997 TDTPGSSTRPVPTQSPSTGPVPTSVMPGASIAGGRYRLLTSHGGPDGLQF * . :: ::*** : .****** *** *** Mvan_6064|M.vanbaalenii_PYR-1 WQALDTALDRQVALTFVDPDATMPDRAVQEILDRTQRLSRIDMPGVARVL Mflv_0842|M.gilvum_PYR-GCK WQATDTALDRQVALTFVAPDATMPDQQVQGILDRTQRLSQIDMPGVARVL TH_2415|M.thermoresistible__bu WQALDTALDRQVALTFVDPDAMLPDEQVQQILSRTLKLSRLNMPGIARVL MSMEG_6929|M.smegmatis_MC2_155 WQALDTALDRQVALTFVDPDAKLPDSQVQDILSRTLKLSRLDVPGIARVL Mb3940|M.bovis_AF2122/97 WQALDTALDRQVALTFVDPQGVLPDDVLQETLSRTLRLSRIDKPGVARVL Rv3910|M.tuberculosis_H37Rv WQALDTALDRQVALTFVDPQGVLPDDVLQETLSRTLRLSRIDKPGVARVL MMAR_5474|M.marinum_M WQALDTALDRQVALTFVDPDGTLPEDVLQEILARTLRLSRIDKPGVARVL MUL_5063|M.ulcerans_Agy99 WQALDTALDRQVALTFVDPDGTLPEDVLQEILARTLRLSRIDKPGVARVL MAV_5298|M.avium_104 WQALDTALDRQVALTFVDPDRALPDEVLQEILSRTLRLSRIDKPGIARVL MLBr_02700|M.leprae_Br4923 WQALDTALDRQVALTFVNPDGALPDDSLQETLSRTLRLSRIDMPGVAQVL MAB_4937|M.abscessus_ATCC_1997 WQATDTELNRPVALTIIDG-AAFTADQVQDILSNTLRLSKIESSGLARVL *** ** *:* ****:: :. :* * .* :**::: .*:*:** Mvan_6064|M.vanbaalenii_PYR-1 DVVSTGVGGLVVSEWIRGGSLAEVADTCPSPIGGARAIQSLAAAAEVAHR Mflv_0842|M.gilvum_PYR-GCK DVLKTATGGLVVSEWIRGGSLAEVAATNPSPIGGARAIQSLAAAAEVAHR TH_2415|M.thermoresistible__bu DVLNTGSGGLIVSEWIRGGSLAEVADTSPSPIGGARAIQSLAAAAEAAHR MSMEG_6929|M.smegmatis_MC2_155 DVAHSGSGGLIVSEWIRGGSLAEVADTAPSPIGGARAIQSLAAAAEAAHR Mb3940|M.bovis_AF2122/97 DVVHTRAGGLVVAEWIRGGSLQEVADTSPSPVGAIRAMQSLAAAADAAHR Rv3910|M.tuberculosis_H37Rv DVVHTRAGGLVVAEWIRGGSLQEVADTSPSPVGAIRAMQSLAAAADAAHR MMAR_5474|M.marinum_M DVLHTASGGLVVSEWIRGGSLQEVADTAPSPVGAIRAMQSLAAAADAAHR MUL_5063|M.ulcerans_Agy99 DVLHTASGGLVVSEWIRGGSLQEVADTAPSPVGAIRAIQSLAAAADAAHR MAV_5298|M.avium_104 DVVHTGSGGLVVSEWIRGGSLQEVADTAPSPVGAVRAMQSLAAAADAAHR MLBr_02700|M.leprae_Br4923 DVIHTGSGGLVVSEWIRGGSLHEVADTSPSPVGAIRAMQSLAAAADAAHR MAB_4937|M.abscessus_ATCC_1997 DAVHEGNGGIVVAQWVRGGSLREVADTEPSAVGASRAVRSLAEAADAAFE *. **::*::*:***** *** * **.:*. **::*** **:.*.. Mvan_6064|M.vanbaalenii_PYR-1 NGVALSIDHPSRIRVSIDGDVALAFPATLPDASPDDDIRGIGASLYALLV Mflv_0842|M.gilvum_PYR-GCK NGVALSIDHPSRIRVSIDGDVALAFPATLPDATPDDDIRGIGASLYALLI TH_2415|M.thermoresistible__bu DGVALSIDHPARVRVSIEGDVALAFPATMPDAEPEDDIRGIGAALYALLI MSMEG_6929|M.smegmatis_MC2_155 AGVALSIDHPSRVRVSIEGDVALAFPATLPDATPDDDIRGIGAALYALLV Mb3940|M.bovis_AF2122/97 AGVALSIDHPSRVRVSIDGDVVLAYPATMPDANPQDDIRGIGASLYALLV Rv3910|M.tuberculosis_H37Rv AGVALSIDHPSRVRVSIDGDVVLAYPATMPDANPQDDIRGIGASLYALLV MMAR_5474|M.marinum_M AGVALSLDHPGRVRVSIEGDVVLAYPATMPDANPQDDIRGIGAALYALLV MUL_5063|M.ulcerans_Agy99 AGVALSLDHPGRVRVSIEGDVVLAYPATMPDANPQDDIRGIGAALYALLV MAV_5298|M.avium_104 AGVALSIDHPSRVRVSIEGDVVLAYPATMPDANPQDDIRGIGAALYALLV MLBr_02700|M.leprae_Br4923 AGVALSIDHPSRVRVSTEGDVVLAYPATMPDANHHTDIRGIGATLYALLV MAB_4937|M.abscessus_ATCC_1997 AGSALSIDHPDRVRISIDGDAVLAFPATLSSASADEDVRGLGAALYALTT * ***:*** *:*:* :**..**:***:..* . *:**:**:**** Mvan_6064|M.vanbaalenii_PYR-1 NRWPLPETGEPSGLAPADLDAAGQPVEPRSVDRDIPFQISAAAAHAVQEG Mflv_0842|M.gilvum_PYR-GCK NRWPLPETGEPSGLAPAELDAAGQPAEPRSIDRDIPFQISAAAAHAVQEG TH_2415|M.thermoresistible__bu NRWPLPESGSPSGLAPAARDAAGEAVEPRTVDRDIPFQISAAAARAVQEG MSMEG_6929|M.smegmatis_MC2_155 NRWPLPESGEPSGLEPAALDAAGQPVEPRAVDRDIPFQISAAAARAVQPG Mb3940|M.bovis_AF2122/97 NRWPLPEAGVRSGLAPAERDTAGQPIEPADIDRDIPFQISAVAARSVQGD Rv3910|M.tuberculosis_H37Rv NRWPLPEAGVRSGLAPAERDTAGQPIEPADIDRDIPFQISAVAARSVQGD MMAR_5474|M.marinum_M NRWPLPEAGADSGFAPAERDASGNPVEPAAVDRDIPFQISAVTVRSVQED MUL_5063|M.ulcerans_Agy99 NRWPLPEAGADSGFAPAERDASGNPVEPAAVDRDIPFQISAVTVRSVQED MAV_5298|M.avium_104 NRWPLAESGVRSGLAPAERDSSGNPVEPMAIDRDIPFQISAVAVRAVQDD MLBr_02700|M.leprae_Br4923 NRWPLPEAGMHSGLAPAQQDTTGQPVEPAVIDQNIPTQISAVTVRAVQED MAB_4937|M.abscessus_ATCC_1997 RRWPLAETGQPSGLPAANRAPDGRPVEARVLIPTVPAEISDVAARALSDD .****.*:* **: .* . *.. *. : :* :** .:.:::. . Mvan_6064|M.vanbaalenii_PYR-1 GGIRSAPTLLNLLQQATAIADRTDHIAPVDDP--------------APPP Mflv_0842|M.gilvum_PYR-GCK GGIRSAPTLLNLLQQATAIADRTDHISPVDEP--------------SPAA TH_2415|M.thermoresistible__bu GGIRSAPTLLNLLQQATAVADRTEVITTVDEG--------------DELP MSMEG_6929|M.smegmatis_MC2_155 GGIRSAPTLLNLLQQATAIADRTELLESVEQT--------------PAAA Mb3940|M.bovis_AF2122/97 GGIRSASTLLNLMQQATAVADRTEVLGPIDE---------------APVS Rv3910|M.tuberculosis_H37Rv GGIRSASTLLNLMQQATAVADRTEVLGPIDE---------------APVS MMAR_5474|M.marinum_M GGIRSASTLLNLLQQATAVADRTEVLGPIEP---------------PAPP MUL_5063|M.ulcerans_Agy99 GGIRSASTLLNLLQQATAVADRTEVLGPIEP---------------PAPP MAV_5298|M.avium_104 GGIRSASTLLNLLQQATAVADRTEVLGPIDD---------------SPSP MLBr_02700|M.leprae_Br4923 GGILRASTLLNLLQQATAVADRTEVLSPIDDR--------------SPTP MAB_4937|M.abscessus_ATCC_1997 PG--SAAELLDGLESAIASVDHTTMLEPAAAAPTQALDVGRRPSFEDPAD * *. **: ::.* * .*:* : . Mvan_6064|M.vanbaalenii_PYR-1 SG-AGFAAELD--PEAAARRRKGLIVGLSVAGAIAVIAVVLLATVLSRIF Mflv_0842|M.gilvum_PYR-GCK VADTSWSADPEDAEEAAARRRRNLTIGLSVAGVIVVVAVILLATVLSRIF TH_2415|M.thermoresistible__bu PP-TRFHDAPDEDPEVQARRRKALLIGVGVGAAIIILALVVLGSILSRIF MSMEG_6929|M.smegmatis_MC2_155 AA-----TPHTDGADAEARRRRALIVGLSAGAAIIVVALVVMATILSRIF Mb3940|M.bovis_AF2122/97 AA---PRTSAPNS-ETYTRRRRNLLIGIGAGAAVLMVALLVLASVLSRIF Rv3910|M.tuberculosis_H37Rv AA---PRTSAPNS-ETYTRRRRNLLIGIGAGAAVLMVALLVLASVLSRIF MMAR_5474|M.marinum_M AP---ARSPAPTG-ATFGRRRRNLLIGIGAGAAILLVALLVLASVLNKMF MUL_5063|M.ulcerans_Agy99 AP---ARSPAPTG-ATFGRRSRNLLIGIGAGAAILLVALLVLASVLNKMF MAV_5298|M.avium_104 ST---ALISPGNDPATFARRRRNVLIGVGAGLAVLVAALLVLASIVSKIF MLBr_02700|M.leprae_Br4923 TA---FCPTTARDPVVFAQRRRNLLIGIGAAVVILVVALLVMASVINKVF MAB_4937|M.abscessus_ATCC_1997 SDDEDYEDYEEEDPEEAARHRKIFLIGLGVVGVLVISLCIALGVWVTRIF :: : . :*:.. .: : : :. :.::* Mvan_6064|M.vanbaalenii_PYR-1 GDVGDGLGGDELGLN--SPSSSTTAQP--GQSGSALKPVSVTVFSPEGEA Mflv_0842|M.gilvum_PYR-GCK GDVGSGLGGDELGLN--APSSSQTDSPS-TATGSALEPVRATVFSPEGEA TH_2415|M.thermoresistible__bu GDVGGNLNRESLGLGGTTPTASATRES--GPPGEVIKPVRATVFSPMGGA MSMEG_6929|M.smegmatis_MC2_155 GDVGGGINRDQLGLNAPSSETESEGGDT-AAAGATVKPVRATVFSPEGEA Mb3940|M.bovis_AF2122/97 GDVSGGLNKDELGLNAPTASTSAASS---APPGSVVKPTKVTVFSPDGGA Rv3910|M.tuberculosis_H37Rv GDVSGGLNKDELGLNAPTASTSAASS---APPGSVVKPTKVTVFSPDGGA MMAR_5474|M.marinum_M GNVGGGLDRDQLGLNAPTASTSAAASS--APAGSVVKPTKATVFSPDGEA MUL_5063|M.ulcerans_Agy99 GNVGGGLDQDQLGLNAPTASTSAAASS--ASAGSVVKPTKATVFSPDGEA MAV_5298|M.avium_104 GNVGGGLNKDELGLNGPSSSTSAPQTTTSAAAGSVVKPTRASVFSLDGDA MLBr_02700|M.leprae_Br4923 GHLGSGLNNDKLGLNTPTSSTSSSPTS-SVPEGSIVKPTKATVFSPDGEA MAB_4937|M.abscessus_ATCC_1997 GDVG-PLDKINIGIGLPTQSSGGDAAK----PGSPAKIVQATVFPPGPDA *.:. :. .:*:. : : * : . .:**. * Mvan_6064|M.vanbaalenii_PYR-1 DAPKLAGLAIDGNPATVWPIDTYTDAAPFPN-FKNGVGLMLQLPEPAKIG Mflv_0842|M.gilvum_PYR-GCK DAPDAASLAIDGDPSTVWPIDTYTDPVPFPN-FKNGVGLMLQLSEPARIG TH_2415|M.thermoresistible__bu DSPGQAGLAIDGDPSTAWPTDTYTDPVPFPN-FKNGVGLMLDLPEETEVG MSMEG_6929|M.smegmatis_MC2_155 DNPGQAELAIDGSSSTMWSTDTYSDPVPFPG-FKNGVGLILQLPQPTVIG Mb3940|M.bovis_AF2122/97 DNPGEADLAIDGNPATSWKTDIYTDPVPFPS-FKNGVGLMLQLPQATVVG Rv3910|M.tuberculosis_H37Rv DNPGEADLAIDGNPATSWKTDIYTDPVPFPS-FKNGVGLMLQLPQATVVG MMAR_5474|M.marinum_M DNPGQADMAIDGDSTTSWETDTYNDPVPFPG-FKNGVGLMLQLPQPTVVG MUL_5063|M.ulcerans_Agy99 DNPGQADMAIDGDSTTSWETDTYNDPVPFPG-FKNGVGLVLQLPQPTVVG MAV_5298|M.avium_104 DNPGTAGQAIDGDPSTAWATEVYTDAVPFPS-FKQGEGLILQLPSPTVVG MLBr_02700|M.leprae_Br4923 DNPDDAGLAIDGNPATSWQTDIYNDAVPFPG-FKNGVGLMLHLPKPTVVS MAB_4937|M.abscessus_ATCC_1997 DQPGKAGLAVDGNPSTSWITDTYTDADPFPVLFKPGVGLLLDLQSSSALS * * * *:**..:* * : *.*. *** ** * **:*.* . : :. Mvan_6064|M.vanbaalenii_PYR-1 SVTVNLNSTGTSVQIRSSETATPSSLEDTTALTDPTPVKPGSNTIEVEDA Mflv_0842|M.gilvum_PYR-GCK SVTVNLNSTGTAVQIRSSSTATPSSLEDTTALTEPTTLKPGSNTIEVDDA TH_2415|M.thermoresistible__bu SVTVRLNSTGTEIQIRSADSANPSSLEDTTALTQPTRMRPGSNTIEIDNP MSMEG_6929|M.smegmatis_MC2_155 SVDLNVTSTGTAVQLRAANSNSPSSLSDTTELTSPTTLKTGSNTISVGRA Mb3940|M.bovis_AF2122/97 TVAIDVASTGTKVEIRSASTPTPATLEDTAVLTSATALRPGHNTISVEAA Rv3910|M.tuberculosis_H37Rv TVAIDVASTGTKVEIRSASTPTPATLEDTAVLTSATALRPGHNTISVEAA MMAR_5474|M.marinum_M SVTLDVPSTGTKVEIRSSPTPNPSKLDDTTVLTSATALKPGSNTIAVNAS MUL_5063|M.ulcerans_Agy99 SVTLDVPSTGTNVEIRSSPTPNPSKLDDTTVLTSATALKPGSNTIAVNAS MAV_5298|M.avium_104 QVSIDTPSTGTKVEIRAASSPTPAGLNDTTVLAPAFTLKPGHNVIPVRAG MLBr_02700|M.leprae_Br4923 AVTIDVASIGTKVEIRSASTPTPAKLADTTVLIPATALKPGHNVIEVNSG MAB_4937|M.abscessus_ATCC_1997 SVTIESHSVGTQVQIRSADSATPGSINDTKEISATATLQSGKTTIPITSS * : * ** :::*:: : .*. : ** : . ::.* ..* : Mvan_6064|M.vanbaalenii_PYR-1 EPTSYVLVWISTLGQVDGESRSDIAEVTLNAAS- Mflv_0842|M.gilvum_PYR-GCK EPTSYVLVWVSTLGQVGGQSRSDIAEITLNAAS- TH_2415|M.thermoresistible__bu RATEHLLVWISTLGQVDGENRTDIAEITLRAPGE MSMEG_6929|M.smegmatis_MC2_155 APTQYLLVWISTLGTVDGKSKTDISDITVKAAS- Mb3940|M.bovis_AF2122/97 APTSNLLVWISTLGTTDGKSQADISEITIYAAS- Rv3910|M.tuberculosis_H37Rv APTSNLLVWISTLGTTDGKSQADISEITIYAAS- MMAR_5474|M.marinum_M SPTSNLLVWISTLGTTDGKSRSAISGLTIRAAS- MUL_5063|M.ulcerans_Agy99 SPTSNLLVWISTLGTTDGKSRSAISQLTIRAAS- MAV_5298|M.avium_104 SPTSNLLVWISTLGTTNGKSQAGFSEITVQAAS- MLBr_02700|M.leprae_Br4923 SPMSNLLVWISTLGSTGGKSLAVISEITIHTPS- MAB_4937|M.abscessus_ATCC_1997 SQVSHVLVWINKLGSTNGDHHAEISEITVSTAS- . :***:..** ..*. : :: :*: :..