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MRPSPGEVPTASQRQPELSDAALVSHSWAMAFATLISRITGFARIVLLAAILGAALASSFSVANQLPNLV AALVLEATFTAIFVPVLARAEQDDPDGGAAFVRRLVTLATTLLLGATTLSVLAAPLLVRLMLGTNPQVNE PLTTAFAYLLLPQVLVYGLSSVFMAILNTRNVFGPPAWAPVVNNVVAIATLAVYLAVPGELSVDPVRMGN AKLLVLGIGTTAGVFAQTAVLLVAIRREHISLRPLWGIDQRLKRFGAMAAAMVLYVLISQLGLVVGNRIA STAAASGPAIYNYTWLVLMLPFGMIGVTVLTVVMPRLSRNAAADDTPAVLADLSLATRLTMITLIPTVAF MTVGGPAIGSALFAYGNFGDVDAGYLGAAIALSAFTLIPYALVLLQLRVFYAREQPWTPITIIVVITGVK ILGSLLAPHITGDPQLVAAYLGLANGLGFLAGTIVGYYILRRALRPDGGQLIGVGEARTALVTVAASLLA GLLAHVADRLLGLSELTAHAGSVGSLLRLSVLALIMLPILAAVTLCARVPEARAALDAVRARIRSRRLKT GPQTQNVLDQSSRPGPVTYPERRRLAPPRGKSVVHEPIRRRPPEQVARAGRAKGPEVIDRPSENASFGAA SGAELPRPVADELQLDAPAGRDPGPVSRPHPSDLQNGDLPADAARGPIAFDALREPDRESSAPPDDVQLV PGARIANGRYRLLIFHGGVPPLQFWQALDTALDRQVALTFVDPQGVLPDDVLQETLSRTLRLSRIDKPGV ARVLDVVHTRAGGLVVAEWIRGGSLQEVADTSPSPVGAIRAMQSLAAAADAAHRAGVALSIDHPSRVRVS IDGDVVLAYPATMPDANPQDDIRGIGASLYALLVNRWPLPEAGVRSGLAPAERDTAGQPIEPADIDRDIP FQISAVAARSVQGDGGIRSASTLLNLMQQATAVADRTEVLGPIDEAPVSAAPRTSAPNSETYTRRRRNLL IGIGAGAAVLMVALLVLASVLSRIFGDVSGGLNKDELGLNAPTASTSAASSAPPGSVVKPTKVTVFSPDG GADNPGEADLAIDGNPATSWKTDIYTDPVPFPSFKNGVGLMLQLPQATVVGTVAIDVASTGTKVEIRSAS TPTPATLEDTAVLTSATALRPGHNTISVEAAAPTSNLLVWISTLGTTDGKSQADISEITIYAAS
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb3940 | - | - | 100% (1184) | transmembrane protein |
M. bovis AF2122 / 97 | Mb2198 | pknL | 4e-08 | 25.44% (283) | transmembrane serine/threonine-protein kinase L |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. gilvum PYR-GCK | Mflv_0842 | - | 0.0 | 63.53% (1212) | integral membrane protein MviN |
M. tuberculosis H37Rv | Rv3910 | - | 0.0 | 99.92% (1184) | transmembrane protein |
M. leprae Br4923 | MLBr_02700 | - | 0.0 | 75.04% (1182) | hypothetical protein MLBr_02700 |
M. abscessus ATCC 19977 | MAB_4937 | - | 0.0 | 51.83% (1200) | hypothetical protein MAB_4937 |
M. marinum M | MMAR_5474 | - | 0.0 | 79.09% (1181) | transmembrane protein |
M. avium 104 | MAV_5298 | - | 0.0 | 76.92% (1196) | virulence factor mvin family protein |
M. smegmatis MC2 155 | MSMEG_6929 | - | 0.0 | 67.33% (1200) | integral membrane protein MviN, putative |
M. thermoresistible (build 8) | TH_2416 | - | 0.0 | 76.47% (510) | PROBABLE CONSERVED TRANSMEMBRANE PROTEIN |
M. ulcerans Agy99 | MUL_5063 | - | 0.0 | 78.41% (1181) | transmembrane protein |
M. vanbaalenii PYR-1 | Mvan_6064 | - | 0.0 | 64.86% (1215) | integral membrane protein MviN |
CLUSTAL 2.0.9 multiple sequence alignment Mflv_0842|M.gilvum_PYR-GCK ---------------------------------------MPDARPEMSDR Mvan_6064|M.vanbaalenii_PYR-1 ------------MRDAAPRRAPTRRPRSSPPPPPPPPRRPQAARPEMSDA MSMEG_6929|M.smegmatis_MC2_155 ------------MNATQPQRPPGPRRLPRGPAP-----RRRAGQEELSDA TH_2416|M.thermoresistible__bu -------------------------------------------------- Mb3940|M.bovis_AF2122/97 -------------------------MRPSPGEVPTASQ----RQPELSDA Rv3910|M.tuberculosis_H37Rv -------------------------MRPSPGEVPTASQ----RQPELSDA MMAR_5474|M.marinum_M ---------------------------MPYGQAAAGPP----KRAELSDA MUL_5063|M.ulcerans_Agy99 ---------------------------MPYGPAAAGPP----KRAELSDA MAV_5298|M.avium_104 MNPAYRQAAPHHRRLPEPPRRPRMPGSPPTGPLPPVPAGIDRRRPELSDS MLBr_02700|M.leprae_Br4923 --------------MKPAPRWTQSQSAQQVTHAMRPCRELSAQQPELSDA MAB_4937|M.abscessus_ATCC_1997 ---------------------------MREPLDPLPDPEADDTIEELSDA Mflv_0842|M.gilvum_PYR-GCK AVVSRSWGMAVATLVSRLTGFARIVLLAAILGAALSSAFTVANQLPNMIA Mvan_6064|M.vanbaalenii_PYR-1 AVVSRSWGMALATLVSRLTGFARIVLLAAILGAALSSAFTVANQLPNMIA MSMEG_6929|M.smegmatis_MC2_155 AVVSRSWGMAMATLISRITGFIRIVLLAAILGAALSSAFSVANQLPNLIA TH_2416|M.thermoresistible__bu -------------------------------------------------- Mb3940|M.bovis_AF2122/97 ALVSHSWAMAFATLISRITGFARIVLLAAILGAALASSFSVANQLPNLVA Rv3910|M.tuberculosis_H37Rv ALVSHSWAMAFATLISRITGFARIVLLAAILGAALASSFSVANQLPNLVA MMAR_5474|M.marinum_M ALVSRSWGMALATLVSRITGFARIVLLAAILGAALSSSFSVANQLPNLVA MUL_5063|M.ulcerans_Agy99 ALVSRSWGMALATLVSRITGFARIVLLAAILGAALSSSFSVANQLPNLVA MAV_5298|M.avium_104 ALVSRSWAMAFATLVSRLTGFARVVLLAAILGAALSSAFSVANQLPNLVA MLBr_02700|M.leprae_Br4923 ALVSRSWAMAFATLISRITGFARVVLLAAILGAALSSAFSVANQLPNLVA MAB_4937|M.abscessus_ATCC_1997 AVVSHSGSMAVATLVSRITGFIKLLLITAALGAASASAFSTANTLPNIIA Mflv_0842|M.gilvum_PYR-GCK ALVLEATFTAIFVPVLARAERDDPDGGAAFIRRLLTLATALLLAVTIIST Mvan_6064|M.vanbaalenii_PYR-1 ALVLEATFTAIFVPVLARAERDDPDGGAAFIRRLLTLATTLLLVVTIIST MSMEG_6929|M.smegmatis_MC2_155 ALVLEATFTAIFVPVLARAERDDPDGGAAFVRRLVTLVTTLLLVTTLVSV TH_2416|M.thermoresistible__bu --VLEATFTAIFVPVLARAERDDPDGGTAFIRRLVTLATTLLLVTTLISV Mb3940|M.bovis_AF2122/97 ALVLEATFTAIFVPVLARAEQDDPDGGAAFVRRLVTLATTLLLGATTLSV Rv3910|M.tuberculosis_H37Rv ALVLEATFTAIFVPVLARAEQDDPDGGAAFVRRLVTLATTLLLGATTLSV MMAR_5474|M.marinum_M ALVLEATFTAIFVPVLARAEQDDPDGGAAFVRRLVTLTTTLLIVATTLSV MUL_5063|M.ulcerans_Agy99 ALVLEATFTAIFVPVLARAEQDDPDGGAAFVRRLVTLTTALLIVATTLSV MAV_5298|M.avium_104 ALVLEATFTAIFVPVLARAEQSDPDGGAAFVRRLVTLTTALLIVATALSV MLBr_02700|M.leprae_Br4923 ALVLEATFTAIFVPVLVRAERSDPDGGTAFVRQLITLTTTLLLLSTTLSV MAB_4937|M.abscessus_ATCC_1997 ALVLEATFTAIFIPVLTRAEREDADGGEAFIRKLLTIVTTLLLVTTLLSV **********:***.***:.*.*** **:*:*:*:.*:**: * :*. Mflv_0842|M.gilvum_PYR-GCK VGAPLLVNLMLGSEPLVNQPLTTAFAFLLLPQIIFYGLSSVFMAILNTRN Mvan_6064|M.vanbaalenii_PYR-1 VAAPLLVDLMLGPDPLVDRPLTTAFAYLLLPQIIFYGLSSVFMAILNTRN MSMEG_6929|M.smegmatis_MC2_155 AAAPALVRLMLGDDPQVNEPLTTAFAYLLLPQVLFYGLSSVFMAILNTRN TH_2416|M.thermoresistible__bu AAAPALTRLMLGGDPQVNEPLTTAFAYLLLPQVLFYGLSSVFMAILNTRN Mb3940|M.bovis_AF2122/97 LAAPLLVRLMLGTNPQVNEPLTTAFAYLLLPQVLVYGLSSVFMAILNTRN Rv3910|M.tuberculosis_H37Rv LAAPLLVRLMLGTNPQVNEPLTTAFAYLLLPQVLVYGLSSVFMAILNTRN MMAR_5474|M.marinum_M LAAPLLVRLMLGRDPQVNEPLTTAFAYLLLPQVLVYGLSSVFMAILNTRN MUL_5063|M.ulcerans_Agy99 LAAPLLVRLMLGRDPQVNEPLTTAFAYLLLPQVLVYGLSSVFIAILNTRN MAV_5298|M.avium_104 AAAPLLVRLMLGRTPQVNEPLTVAFAYLLLPQVLAYGLTSVFMAILNTRN MLBr_02700|M.leprae_Br4923 LAAPLLVRLMLGRNPQVNEPLTTAFAYLLLPQVLAYGLSSVFMAILNTRN MAB_4937|M.abscessus_ATCC_1997 LAAPLLAGIMLGGDPKVNTPLTTALAYLLLPQVFFYGLSSLFMAILNTRN .** *. :*** * *: ***.*:*:*****:: ***:*:*:******* Mflv_0842|M.gilvum_PYR-GCK IFGPPAWAPVVNNVVAIATLGLYVLVPGELSLDPVRMGDAKLLVLGIGTT Mvan_6064|M.vanbaalenii_PYR-1 VFGPPAWAPVVNNVVAILTLGLYVLVPGELSLNPVQMGDAKLLVLGVGTT MSMEG_6929|M.smegmatis_MC2_155 VFGPPAWAPVLNNVVAIATLGAYLLVPGELSVDPVQMGNAKLLVLGVGTT TH_2416|M.thermoresistible__bu VFGPPAWAPVVNNVVAIATLGLYLLVPGELSVDPVEMGNAKLLVLGIGTT Mb3940|M.bovis_AF2122/97 VFGPPAWAPVVNNVVAIATLAVYLAVPGELSVDPVRMGNAKLLVLGIGTT Rv3910|M.tuberculosis_H37Rv VFGPPAWAPVVNNVVAIATLAVYLAVPGELSVDPVRMGNAKLLVLGIGTT MMAR_5474|M.marinum_M VFGPPAWAPVINNVVAIATLLVYLAVPGELAIDPVKMGNAKLLVLGVGTT MUL_5063|M.ulcerans_Agy99 VFGPPAWAPVINNGVAIATLLVYLAVPGELAVDPVKMGNAKLLVLGVGTT MAV_5298|M.avium_104 VFGPTAWAPVVNNVVALATLAVYALVPGELSVDPVRMGNAKLLVLAVGTT MLBr_02700|M.leprae_Br4923 VFGPPAWAPVINNIVAIAALVGYLVTPGELSVDPVRMGNAKLLVLGIGTT MAB_4937|M.abscessus_ATCC_1997 VFGPPAWAPVWNNLVAIATLVLYWLMPGELTLDPIRMSDPKLLVLGIGTT :***.***** ** **: :* * ****:::*:.*.:.*****.:*** Mflv_0842|M.gilvum_PYR-GCK LGVVAQAAVLFVAIRRERISLRPLWGIDARLKKFGMMALAMVLYVLVSQV Mvan_6064|M.vanbaalenii_PYR-1 LGVVAQAGVLFMAIRRQRVSLRPLWGIDARLKKFGMMAVAMVLYVLISQV MSMEG_6929|M.smegmatis_MC2_155 LGVVAQCSVLLPAIRRERISLRPLWGIDDRLKKFGAMAAAMVLYVLISQI TH_2416|M.thermoresistible__bu LGVVAQCGVLVVAIRRERISLRPLWGIDDRLKRFGTMAAAMVLYVLISQI Mb3940|M.bovis_AF2122/97 AGVFAQTAVLLVAIRREHISLRPLWGIDQRLKRFGAMAAAMVLYVLISQL Rv3910|M.tuberculosis_H37Rv AGVFAQTAVLLVAIRREHISLRPLWGIDQRLKRFGAMAAAMVLYVLISQL MMAR_5474|M.marinum_M LGVFAQAAVLLVAIGRQHISLRPLWGIDDRLKRFGAMAAAMVLYVLISQL MUL_5063|M.ulcerans_Agy99 LGVFAQAAVLLVAIGRQHISLRPLWGIDDRLKRFGAMAAAMVLYVLVSQL MAV_5298|M.avium_104 LGVFAQTGVLLVALRRQHVDLRPLWGIDQRLKRFGTLAAAMVLYVLISQL MLBr_02700|M.leprae_Br4923 AGAFAQTAVLLVALGREHISLHPLWGLDQRLKRFGAMATAMVLYVLISQL MAB_4937|M.abscessus_ATCC_1997 LGVAAQAMVLLPAIRRQQIPLRPLWGLDDRLKQFGGMAAAMFAYVAISQF *. ** **. *: *::: *:****:* ***:** :* **. ** :**. Mflv_0842|M.gilvum_PYR-GCK GFIVGNQVASASAASGPAIYNYTWLILQLPFGIVGVTVLTVVMPRLSRNA Mvan_6064|M.vanbaalenii_PYR-1 GFIVGNQVASTAAASGPAIYNYTWLILQLPFGIVGVTVLTVVMPRLSRNA MSMEG_6929|M.smegmatis_MC2_155 GLVVGNQIASGAAASGPAIYNYAWLVLQLPFGMIGVTVLTVVMPRLSRNA TH_2416|M.thermoresistible__bu GLVVGNQIASGAAASGPAIYNYTWLVLMLPFGMIGVTVLTVVMPRLSRNA Mb3940|M.bovis_AF2122/97 GLVVGNRIASTAAASGPAIYNYTWLVLMLPFGMIGVTVLTVVMPRLSRNA Rv3910|M.tuberculosis_H37Rv GLVVGNRIASTAAASGPAIYNYTWLVLMLPFGMIGVTVLTVVMPRLSRNA MMAR_5474|M.marinum_M GLIVGNQIASGAAASGPAIYNYTWLVLMLPFGMIGVTVLTVVMPRLSRNA MUL_5063|M.ulcerans_Agy99 GLIVGNQIASGAAASGPAIYNYTWLVLMLPFGMIGVTVLTVVMPRLSRNA MAV_5298|M.avium_104 GLVVGNQIASTAAASGPAIYNYTWLVLMLPFGMIGVTVLTVVMPRLSRNA MLBr_02700|M.leprae_Br4923 GLVVTNQIASTTAASGPAIYNYTWLVLMLPFGIIGVTVLTVVMPRLSRNA MAB_4937|M.abscessus_ATCC_1997 GYVIANRIAAGAAESGPIIYSQTWMILQLPYGVVGVTILTAIMPRLSRNA * :: *::*: :* *** **. :*::* **:*::***:**.:******** Mflv_0842|M.gilvum_PYR-GCK ASGDGGAVLADLSLATRLTMLTLIPIVALMTVGGPAIGSALFSYGNFGAV Mvan_6064|M.vanbaalenii_PYR-1 AADDAPAVLADLSLATRLTMITLIPIVAMMTVGGPAIGSALFSYGNFGAV MSMEG_6929|M.smegmatis_MC2_155 AKNDIPAVLGDLSLATRLTMITLIPIVALMTVGGPAIGTALFAYGNFGRV TH_2416|M.thermoresistible__bu AAEDVPAVLRDFALAIRLTMVTLIPIVAVMTVGGPAIGTALFAYGNFGSV Mb3940|M.bovis_AF2122/97 AADDTPAVLADLSLATRLTMITLIPTVAFMTVGGPAIGSALFAYGNFGDV Rv3910|M.tuberculosis_H37Rv AADDTPAVLADLSLATRLTMITLIPTVAFMTVGGPAIGSALFAYGNFGDV MMAR_5474|M.marinum_M AAEDIPAVLADLSLATRLTMITLIPTVAFMTVGGSAMGSALFAYGNFGKV MUL_5063|M.ulcerans_Agy99 AAEDILAVLADLSLATRLTMITLIPTVAFMTVGGSAMGSALFAYGNFGKV MAV_5298|M.avium_104 AADDTRAVLADLSLATRLTLITLIPIVAFMTVGGPAMGSALFAYGHFGDV MLBr_02700|M.leprae_Br4923 AANDTPAMLADLSLATRLTLITLIPTVAFMTAGGSAMGSVLFAYGHFGEV MAB_4937|M.abscessus_ATCC_1997 AAQDTPAVLGDMSLATRLTMTVLIPVVAVMTVAGPAMGPALFAYGNFHLG * * *:* *::** ***: .*** **.**..*.*:*..**:**:* Mflv_0842|M.gilvum_PYR-GCK DAGYLGMAITLSAFTLIPYTMVLLQLRVFYAREEPWTPIVLIVVITIVKI Mvan_6064|M.vanbaalenii_PYR-1 DAGYLGMAITLSAFTLIPYTLVLLQLRVFYAREEPWTPILLIIVITIVKI MSMEG_6929|M.smegmatis_MC2_155 DAGYLGLAISLSAFTLIPYALVLLQLRVFYARERAWTPIIVIIVITVVKI TH_2416|M.thermoresistible__bu DAGYLGMAITLSAFTLIPYALVLLQLRVFYARERPWTPIIVIVVITAVKI Mb3940|M.bovis_AF2122/97 DAGYLGAAIALSAFTLIPYALVLLQLRVFYAREQPWTPITIIVVITGVKI Rv3910|M.tuberculosis_H37Rv DAGYLGAAIALSAFTLIPYALVLLQLRVFYAREQPWTPITIIVVITGVKI MMAR_5474|M.marinum_M DAGYLGAAIALSAFTLIPYALVLLGLRVFYAREQPWTPILIIIIITSVKI MUL_5063|M.ulcerans_Agy99 DAGYLGAAIALSAFTLIPYALVLLGLRVFYAREQPWTPILIIIIITSVKI MAV_5298|M.avium_104 DAGYLGAAIALSAFTLIPYGLVLLQLRVFYAREQPWTPIVIILVITAVKI MLBr_02700|M.leprae_Br4923 DAGYLGTAIVLSAFTLIPYGLVLLQLRVFYAREQPWTPIVIIVVITAVRI MAB_4937|M.abscessus_ATCC_1997 SAHYLGLSISLSAFTLIPYALVLLQLRVFYARHEAWTPTLMIIVITAVKV .* *** :* ********* :*** *******...*** :*::** *:: Mflv_0842|M.gilvum_PYR-GCK AASLASPHLTDDPQLVAGYLGLANGLGFLAGATVGYLLLRARLDPPGGHL Mvan_6064|M.vanbaalenii_PYR-1 AASLAAPHLTADPQLVAGYLGLANGLGFLAGATVGYLLLRARLDPPGGRL MSMEG_6929|M.smegmatis_MC2_155 AGSVAAPHLTNNPEMVAGYLGAANGLGFMAGAIVGHVLLRANLDPPGGRL TH_2416|M.thermoresistible__bu AASVAAPHLTSDPDLVAGYLGLANGLGFAAGAVVGHLLLRAHLDPPGGRL Mb3940|M.bovis_AF2122/97 LGSLLAPHITGDPQLVAAYLGLANGLGFLAGTIVGYYILRRALRPDGGQL Rv3910|M.tuberculosis_H37Rv LGSLLAPHITGDPQLVAAYLGLANGLGFLAGTIVGYYILRRALRPDGGQL MMAR_5474|M.marinum_M GASVLAPHLTNDPDMVAGYLGLANGLGFLAGAIVGYYLLRRALRPGGGQL MUL_5063|M.ulcerans_Agy99 GASVLAPHLTNDPDMVAGYLGLANGLGFLAGAIVGYYLLRRALCPGGGQL MAV_5298|M.avium_104 LGSVLAPHLTGDPKLVAGFLGLANGVGFLAGAVIGYVLLRRTLLPGGGHL MLBr_02700|M.leprae_Br4923 IVSVLAPYVISNPELVAGYLGMANGLGFAAGAIVGYYLLRRALLPTGGHL MAB_4937|M.abscessus_ATCC_1997 IGSVAAPHLTDDPDLVAGYLGAANGLGFVAGALCGYLLLRRSLGRAAGPL *: :*:: :*.:**.:** ***:** **: *: :** * .* * Mflv_0842|M.gilvum_PYR-GCK VSRDVVRTILVTITASLAAGLIAHIADQILGLEQLTEHWGGGGSLIRLAV Mvan_6064|M.vanbaalenii_PYR-1 LDNAVIRTILVTITASLAAGLTAHVVDQLAGLENLTTHWGAAGSLLRLLA MSMEG_6929|M.smegmatis_MC2_155 VSLTVVRTILVTITASLLAVLVSVVVDQLLGVEQLTVRFGAGGSMIRLVV TH_2416|M.thermoresistible__bu LEPAVVRTVLVTIAASLTAALIGQIADQLLGLEQLTANGGGAGSLLRLLV Mb3940|M.bovis_AF2122/97 IGVGEARTALVTVAASLLAGLLAHVADRLLGLSELTAHAGSVGSLLRLSV Rv3910|M.tuberculosis_H37Rv IGVGEARTVLVTVAASLLAGLLAHVADRLLGLSELTAHAGSVGSLLRLSV MMAR_5474|M.marinum_M VGTREVHTILVTIAASLLAGLLAYVVDRLAGLGQLTVFGGGIGSLLRLLI MUL_5063|M.ulcerans_Agy99 VGTREVHTILVTIAASLLAGLLAYVVDRLAGLGQLTVFDGGIGSLLRLLI MAV_5298|M.avium_104 IGVGEVRTILVTLTAAMLAGLVAHVADRLLGLSALTAHGGGAGSLLRLLV MLBr_02700|M.leprae_Br4923 FGVQEIRTVLVTIAASLLAGLAAHIADRLLRLNELTMHGGGAGSLLRLTV MAB_4937|M.abscessus_ATCC_1997 IGPDVARTALVALAASVTAAAVGLGIDRGFGLDLLTQRGGGLGSILRLAI . :* **:::*:: * . *: : ** *. **::** Mflv_0842|M.gilvum_PYR-GCK LGLVMGPIILGVLIAAKVPDALAGVAAVRRRLGARG-------------- Mvan_6064|M.vanbaalenii_PYR-1 LGLVMVPIIAAVMLTAKVPEAQAALAAVRRRLGTRG-------------- MSMEG_6929|M.smegmatis_MC2_155 LGLIMLPIIAGVLIAAKVPEAQAAIRVVRGRLGRFGGKETPAVDAAEKVA TH_2416|M.thermoresistible__bu LGLIMAPVIAAFLWFARVPEAEAAVAAVRRRFGKTP-------------- Mb3940|M.bovis_AF2122/97 LALIMLPILAAVTLCARVPEARAALDAVRARIRSRRLKTGPQ-------- Rv3910|M.tuberculosis_H37Rv LALIMLPILAAVTLCARVPEARAALDAVRARIRSRRLKTGPQ-------- MMAR_5474|M.marinum_M LGVIMAPIVIAVLLAGQVPEAQAALNVVRNRIGTRLGKPGPR-------- MUL_5063|M.ulcerans_Agy99 LGVIMAPIVIAVLLAGQVPEAQAALNVVRNRIGTRLGKPGPR-------- MAV_5298|M.avium_104 LALIMVPITAAVMLRAQVPEARAALDAVRFRITGR--GPRPR-------- MLBr_02700|M.leprae_Br4923 LTSIMLPTMAVVMLRGHVPEVHAALGAVRGQIMSRNWIAKLQ-------- MAB_4937|M.abscessus_ATCC_1997 LGIVMLAVTFALMVAVKLPEALSVVAMLQRRLGGRLG------------- * :* . . ::*:. : : :: :: Mflv_0842|M.gilvum_PYR-GCK -ATTGSPVPQMSPRALTYADRSNR--------------RGPSAETADDGR Mvan_6064|M.vanbaalenii_PYR-1 -PAAEPSVRPRPSDTLTYPDHKNRSSL-RRRQLPRSAARGPSAEAADDGR MSMEG_6929|M.smegmatis_MC2_155 LQTNGPAVPPRTAGAVTYPDQRNSSPG-RGPTTPAPGWVGAPASVAGAGT TH_2416|M.thermoresistible__bu -------------------------------------ASGPAPVTAGDRR Mb3940|M.bovis_AF2122/97 --TQNVLDQSSRPGPVTYPERRRLAPPRGKSVVHEPIRRRPPEQVARAGR Rv3910|M.tuberculosis_H37Rv --TQNVLDQSSRPGPVTYPERRRLAPPRGKSVVHEPIRRRPPEQVARAGR MMAR_5474|M.marinum_M --SVAVPDASSGDHDVTYPEQRKSSLP-GENVVQEPIRRKPP--VIRAGI MUL_5063|M.ulcerans_Agy99 --SVAVLDPSSGDHDVTYPEQRKSSLP-GENVVQEPIRRKPP--VIRAGI MAV_5298|M.avium_104 --KPAAPDRSSHRRPVTYPEQRNSSPP-GVNAVQEPIRRRPPERANRARL MLBr_02700|M.leprae_Br4923 --KATVPDQSSRPITVTYPGQNNSSPP-RVNAIQESIRSRPPERIAKAQI MAB_4937|M.abscessus_ATCC_1997 ----------------------------------ARLRAETQDHASVMGN . Mflv_0842|M.gilvum_PYR-GCK RKGSAVSDKPTSDSPSGPDSTAPPSGPNSTAPPSGPNSTAPPSGPNSTAP Mvan_6064|M.vanbaalenii_PYR-1 RKGFAVSDKPTSGSPGGPDSAATTR----------------------ITR MSMEG_6929|M.smegmatis_MC2_155 RKGSPVTDESAGG--PALDGTATTK----------------------LPR TH_2416|M.thermoresistible__bu CTG----------------------------------------------- Mb3940|M.bovis_AF2122/97 AKGPEVIDRPSE-NASFG-AASGA----------------------ELPR Rv3910|M.tuberculosis_H37Rv AKGPEVIDRPSE-NASFG-AASGA----------------------ELPR MMAR_5474|M.marinum_M AKGPSVTDRPSDSTASSS-SASDI----------------------DLPR MUL_5063|M.ulcerans_Agy99 AKGPSVTDRPSDSTASSS-SASDI----------------------DLPR MAV_5298|M.avium_104 VKGPEVTDRPMESAASSAGPGTGS----------------------GAPR MLBr_02700|M.leprae_Br4923 AKGPEVSDRPVESASSRSASDTGLP--------------------SELPR MAB_4937|M.abscessus_ATCC_1997 SPGPSLPYPDSGDPVGGSDAIGST-----------------------TAN * Mflv_0842|M.gilvum_PYR-GCK PSADDFQPDVPDSYQPDPAADDSATTALP-AQGVPTQSPSKSPTETPTEA Mvan_6064|M.vanbaalenii_PYR-1 PSPDDFQPDVPEDAGTHVLPQAPARPTGPESAARPTGPESAARPAGPESA MSMEG_6929|M.smegmatis_MC2_155 QAPDDFQPDVADDES----EAAGAEPTVEETVSLPNGS------------ TH_2416|M.thermoresistible__bu --AD---------------------------------------------- Mb3940|M.bovis_AF2122/97 PVADELQLDAPAG--RDPGPVSRPHPS----------------------- Rv3910|M.tuberculosis_H37Rv PVADELQLDAPAG--RDPGPVSRPHPS----------------------- MMAR_5474|M.marinum_M PVADDFQPDIPAG--PDRGRGASQRPS----------------------- MUL_5063|M.ulcerans_Agy99 PVADDFQPDIPAG--PDRGRGASLRPS----------------------- MAV_5298|M.avium_104 PVADDFQPDIPADQ-PDRPRKADPRPA----------------------- MLBr_02700|M.leprae_Br4923 PVAGNSQPYISAN--LELEHVASLHPP----------------------- MAB_4937|M.abscessus_ATCC_1997 KPAHGGGADTRKG------------------------------------- . Mflv_0842|M.gilvum_PYR-GCK VKRPRADYSNDPTREALAFDPPREPAIETATPAEDTHLIPGATIAGGRYR Mvan_6064|M.vanbaalenii_PYR-1 ARPPVSDYAGDPTREALPFDPPREPATEAATTAEDMHLIPGATIVDGRYR MSMEG_6929|M.smegmatis_MC2_155 -GRPPADYGGDPTREPISFAPPREPAVESATSGDDVHLIPGATIADGRYR TH_2416|M.thermoresistible__bu -SQPGGDYRG------------RIPARSAFP-------VP---------- Mb3940|M.bovis_AF2122/97 -DLQNGDLPADAARGPIAFDALREPDRESSAPPDDVQLVPGARIANGRYR Rv3910|M.tuberculosis_H37Rv -DLQNGDLPADAARGPIAFDALREPDRESSAPPDDVQLVPGARIANGRYR MMAR_5474|M.marinum_M -DQSNGDS-VGYTRGPIPFDAPRERSAEPSTPQDDVNLVPGARIANGRYR MUL_5063|M.ulcerans_Agy99 -DLSNGDS-VGYTRGPIPFDAPRECSAEPSTPQDDVNLVPGARIANGRYR MAV_5298|M.avium_104 -DQKNGDA--GTRRG--PFDVPRERAADSSA--DDVHLVPGARIAGGRYR MLBr_02700|M.leprae_Br4923 -EQQKVDFPAYPARRPIRFEVSRERGGEQSSPTGDVHLVPGACIAGGRYR MAB_4937|M.abscessus_ATCC_1997 --RAVTDTPGSSTRP--------VPTQSPSTGPVPTSVMPGASIAGGRYR * . . :* Mflv_0842|M.gilvum_PYR-GCK LLVSHGGPEHLQFWQATDTALDRQVALTFVAPDATMPDQQVQGILDRTQR Mvan_6064|M.vanbaalenii_PYR-1 LLVSHGGPAHLQFWQALDTALDRQVALTFVDPDATMPDRAVQEILDRTQR MSMEG_6929|M.smegmatis_MC2_155 LLVFHGGPPHLQFWQALDTALDRQVALTFVDPDAKLPDSQVQDILSRTLK TH_2416|M.thermoresistible__bu -------------------------------------------------- Mb3940|M.bovis_AF2122/97 LLIFHGGVPPLQFWQALDTALDRQVALTFVDPQGVLPDDVLQETLSRTLR Rv3910|M.tuberculosis_H37Rv LLIFHGGVPPLQFWQALDTALDRQVALTFVDPQGVLPDDVLQETLSRTLR MMAR_5474|M.marinum_M LLVFHGGIPPLQFWQALDTALDRQVALTFVDPDGTLPEDVLQEILARTLR MUL_5063|M.ulcerans_Agy99 LLVFHGGIPPLQFWQALDTALDRQVALTFVDPDGTLPEDVLQEILARTLR MAV_5298|M.avium_104 LLVFHGGAPPLQFWQALDTALDRQVALTFVDPDRALPDEVLQEILSRTLR MLBr_02700|M.leprae_Br4923 LLAFHGGAPSLQFWQALDTALDRQVALTFVNPDGALPDDSLQETLSRTLR MAB_4937|M.abscessus_ATCC_1997 LLTSHGGPDGLQFWQATDTELNRPVALTIIDG-AAFTADQVQDILSNTLR Mflv_0842|M.gilvum_PYR-GCK LSQIDMPGVARVLDVLKTATGGLVVSEWIRGGSLAEVAATNPSPIGGARA Mvan_6064|M.vanbaalenii_PYR-1 LSRIDMPGVARVLDVVSTGVGGLVVSEWIRGGSLAEVADTCPSPIGGARA MSMEG_6929|M.smegmatis_MC2_155 LSRLDVPGIARVLDVAHSGSGGLIVSEWIRGGSLAEVADTAPSPIGGARA TH_2416|M.thermoresistible__bu -------------------------------------------------- Mb3940|M.bovis_AF2122/97 LSRIDKPGVARVLDVVHTRAGGLVVAEWIRGGSLQEVADTSPSPVGAIRA Rv3910|M.tuberculosis_H37Rv LSRIDKPGVARVLDVVHTRAGGLVVAEWIRGGSLQEVADTSPSPVGAIRA MMAR_5474|M.marinum_M LSRIDKPGVARVLDVLHTASGGLVVSEWIRGGSLQEVADTAPSPVGAIRA MUL_5063|M.ulcerans_Agy99 LSRIDKPGVARVLDVLHTASGGLVVSEWIRGGSLQEVADTAPSPVGAIRA MAV_5298|M.avium_104 LSRIDKPGIARVLDVVHTGSGGLVVSEWIRGGSLQEVADTAPSPVGAVRA MLBr_02700|M.leprae_Br4923 LSRIDMPGVAQVLDVIHTGSGGLVVSEWIRGGSLHEVADTSPSPVGAIRA MAB_4937|M.abscessus_ATCC_1997 LSKIESSGLARVLDAVHEGNGGIVVAQWVRGGSLREVADTEPSAVGASRA Mflv_0842|M.gilvum_PYR-GCK IQSLAAAAEVAHRNGVALSIDHPSRIRVSIDGDVALAFPATLPDATPDDD Mvan_6064|M.vanbaalenii_PYR-1 IQSLAAAAEVAHRNGVALSIDHPSRIRVSIDGDVALAFPATLPDASPDDD MSMEG_6929|M.smegmatis_MC2_155 IQSLAAAAEAAHRAGVALSIDHPSRVRVSIEGDVALAFPATLPDATPDDD TH_2416|M.thermoresistible__bu -------------------------------------------------- Mb3940|M.bovis_AF2122/97 MQSLAAAADAAHRAGVALSIDHPSRVRVSIDGDVVLAYPATMPDANPQDD Rv3910|M.tuberculosis_H37Rv MQSLAAAADAAHRAGVALSIDHPSRVRVSIDGDVVLAYPATMPDANPQDD MMAR_5474|M.marinum_M MQSLAAAADAAHRAGVALSLDHPGRVRVSIEGDVVLAYPATMPDANPQDD MUL_5063|M.ulcerans_Agy99 IQSLAAAADAAHRAGVALSLDHPGRVRVSIEGDVVLAYPATMPDANPQDD MAV_5298|M.avium_104 MQSLAAAADAAHRAGVALSIDHPSRVRVSIEGDVVLAYPATMPDANPQDD MLBr_02700|M.leprae_Br4923 MQSLAAAADAAHRAGVALSIDHPSRVRVSTEGDVVLAYPATMPDANHHTD MAB_4937|M.abscessus_ATCC_1997 VRSLAEAADAAFEAGSALSIDHPDRVRISIDGDAVLAFPATLSSASADED Mflv_0842|M.gilvum_PYR-GCK IRGIGASLYALLINRWPLPETGEPSGLAPAELDAAGQPAEPRSIDRDIPF Mvan_6064|M.vanbaalenii_PYR-1 IRGIGASLYALLVNRWPLPETGEPSGLAPADLDAAGQPVEPRSVDRDIPF MSMEG_6929|M.smegmatis_MC2_155 IRGIGAALYALLVNRWPLPESGEPSGLEPAALDAAGQPVEPRAVDRDIPF TH_2416|M.thermoresistible__bu -------------------------------------------------- Mb3940|M.bovis_AF2122/97 IRGIGASLYALLVNRWPLPEAGVRSGLAPAERDTAGQPIEPADIDRDIPF Rv3910|M.tuberculosis_H37Rv IRGIGASLYALLVNRWPLPEAGVRSGLAPAERDTAGQPIEPADIDRDIPF MMAR_5474|M.marinum_M IRGIGAALYALLVNRWPLPEAGADSGFAPAERDASGNPVEPAAVDRDIPF MUL_5063|M.ulcerans_Agy99 IRGIGAALYALLVNRWPLPEAGADSGFAPAERDASGNPVEPAAVDRDIPF MAV_5298|M.avium_104 IRGIGAALYALLVNRWPLAESGVRSGLAPAERDSSGNPVEPMAIDRDIPF MLBr_02700|M.leprae_Br4923 IRGIGATLYALLVNRWPLPEAGMHSGLAPAQQDTTGQPVEPAVIDQNIPT MAB_4937|M.abscessus_ATCC_1997 VRGLGAALYALTTRRWPLAETGQPSGLPAANRAPDGRPVEARVLIPTVPA Mflv_0842|M.gilvum_PYR-GCK QISAAAAHAVQEGGGIRSAPTLLNLLQQATAIADRTDHISPVDEP----- Mvan_6064|M.vanbaalenii_PYR-1 QISAAAAHAVQEGGGIRSAPTLLNLLQQATAIADRTDHIAPVDDP----- MSMEG_6929|M.smegmatis_MC2_155 QISAAAARAVQPGGGIRSAPTLLNLLQQATAIADRTELLESVEQT----- TH_2416|M.thermoresistible__bu -------------------------------------------------- Mb3940|M.bovis_AF2122/97 QISAVAARSVQGDGGIRSASTLLNLMQQATAVADRTEVLGPIDE------ Rv3910|M.tuberculosis_H37Rv QISAVAARSVQGDGGIRSASTLLNLMQQATAVADRTEVLGPIDE------ MMAR_5474|M.marinum_M QISAVTVRSVQEDGGIRSASTLLNLLQQATAVADRTEVLGPIEP------ MUL_5063|M.ulcerans_Agy99 QISAVTVRSVQEDGGIRSASTLLNLLQQATAVADRTEVLGPIEP------ MAV_5298|M.avium_104 QISAVAVRAVQDDGGIRSASTLLNLLQQATAVADRTEVLGPIDD------ MLBr_02700|M.leprae_Br4923 QISAVTVRAVQEDGGILRASTLLNLLQQATAVADRTEVLSPIDDR----- MAB_4937|M.abscessus_ATCC_1997 EISDVAARALSDDPG--SAAELLDGLESAIASVDHTTMLEPAAAAPTQAL Mflv_0842|M.gilvum_PYR-GCK ---------SPAAVADTSWSADPEDAEEAAARRRRNLTIGLSVAGVIVVV Mvan_6064|M.vanbaalenii_PYR-1 ---------APPPSG-AGFAAELD--PEAAARRRKGLIVGLSVAGAIAVI MSMEG_6929|M.smegmatis_MC2_155 ----------PAAAAATPHTDGAD----AEARRRRALIVGLSAGAAIIVV TH_2416|M.thermoresistible__bu -------------------------------------------------- Mb3940|M.bovis_AF2122/97 ---------APVSAAPRTSAPNS----ETYTRRRRNLLIGIGAGAAVLMV Rv3910|M.tuberculosis_H37Rv ---------APVSAAPRTSAPNS----ETYTRRRRNLLIGIGAGAAVLMV MMAR_5474|M.marinum_M ---------PAPPAPARSPAPTG----ATFGRRRRNLLIGIGAGAAILLV MUL_5063|M.ulcerans_Agy99 ---------PAPPAPARSPAPTG----ATFGRRSRNLLIGIGAGAAILLV MAV_5298|M.avium_104 ---------SPSPSTALISPGNDP---ATFARRRRNVLIGVGAGLAVLVA MLBr_02700|M.leprae_Br4923 ---------SPTPTAFCPTTARDP---VVFAQRRRNLLIGIGAAVVILVV MAB_4937|M.abscessus_ATCC_1997 DVGRRPSFEDPADSDDEDYEDYEEEDPEEAARHRKIFLIGLGVVGVLVIS Mflv_0842|M.gilvum_PYR-GCK AVILLATVLSRIFGDVGSGLGGDELGLNAPSSSQTDSPS---TATGSALE Mvan_6064|M.vanbaalenii_PYR-1 AVVLLATVLSRIFGDVGDGLGGDELGLNSPSSSTTAQP----GQSGSALK MSMEG_6929|M.smegmatis_MC2_155 ALVVMATILSRIFGDVGGGINRDQLGLNAPSSETESEGGD-TAAAGATVK TH_2416|M.thermoresistible__bu -------------------------------------------------- Mb3940|M.bovis_AF2122/97 ALLVLASVLSRIFGDVSGGLNKDELGLNAPTASTSAASS---APPGSVVK Rv3910|M.tuberculosis_H37Rv ALLVLASVLSRIFGDVSGGLNKDELGLNAPTASTSAASS---APPGSVVK MMAR_5474|M.marinum_M ALLVLASVLNKMFGNVGGGLDRDQLGLNAPTASTSAAASS--APAGSVVK MUL_5063|M.ulcerans_Agy99 ALLVLASVLNKMFGNVGGGLDQDQLGLNAPTASTSAAASS--ASAGSVVK MAV_5298|M.avium_104 ALLVLASIVSKIFGNVGGGLNKDELGLNGPSSSTSAPQTTTSAAAGSVVK MLBr_02700|M.leprae_Br4923 ALLVMASVINKVFGHLGSGLNNDKLGLNTPTSSTSSSPTS-SVPEGSIVK MAB_4937|M.abscessus_ATCC_1997 LCIALGVWVTRIFGDVGP-LDKINIGIGLPTQSSGGDAAK----PGSPAK Mflv_0842|M.gilvum_PYR-GCK PVRATVFSPEGEADAPDAASLAIDGDPSTVWPIDTYTDPVPFPN-FKNGV Mvan_6064|M.vanbaalenii_PYR-1 PVSVTVFSPEGEADAPKLAGLAIDGNPATVWPIDTYTDAAPFPN-FKNGV MSMEG_6929|M.smegmatis_MC2_155 PVRATVFSPEGEADNPGQAELAIDGSSSTMWSTDTYSDPVPFPG-FKNGV TH_2416|M.thermoresistible__bu -------------------------------------------------- Mb3940|M.bovis_AF2122/97 PTKVTVFSPDGGADNPGEADLAIDGNPATSWKTDIYTDPVPFPS-FKNGV Rv3910|M.tuberculosis_H37Rv PTKVTVFSPDGGADNPGEADLAIDGNPATSWKTDIYTDPVPFPS-FKNGV MMAR_5474|M.marinum_M PTKATVFSPDGEADNPGQADMAIDGDSTTSWETDTYNDPVPFPG-FKNGV MUL_5063|M.ulcerans_Agy99 PTKATVFSPDGEADNPGQADMAIDGDSTTSWETDTYNDPVPFPG-FKNGV MAV_5298|M.avium_104 PTRASVFSLDGDADNPGTAGQAIDGDPSTAWATEVYTDAVPFPS-FKQGE MLBr_02700|M.leprae_Br4923 PTKATVFSPDGEADNPDDAGLAIDGNPATSWQTDIYNDAVPFPG-FKNGV MAB_4937|M.abscessus_ATCC_1997 IVQATVFPPGPDADQPGKAGLAVDGNPSTSWITDTYTDADPFPVLFKPGV Mflv_0842|M.gilvum_PYR-GCK GLMLQLSEPARIGSVTVNLNSTGTAVQIRSSSTATPSSLEDTTALTEPTT Mvan_6064|M.vanbaalenii_PYR-1 GLMLQLPEPAKIGSVTVNLNSTGTSVQIRSSETATPSSLEDTTALTDPTP MSMEG_6929|M.smegmatis_MC2_155 GLILQLPQPTVIGSVDLNVTSTGTAVQLRAANSNSPSSLSDTTELTSPTT TH_2416|M.thermoresistible__bu -------------------------------------------------- Mb3940|M.bovis_AF2122/97 GLMLQLPQATVVGTVAIDVASTGTKVEIRSASTPTPATLEDTAVLTSATA Rv3910|M.tuberculosis_H37Rv GLMLQLPQATVVGTVAIDVASTGTKVEIRSASTPTPATLEDTAVLTSATA MMAR_5474|M.marinum_M GLMLQLPQPTVVGSVTLDVPSTGTKVEIRSSPTPNPSKLDDTTVLTSATA MUL_5063|M.ulcerans_Agy99 GLVLQLPQPTVVGSVTLDVPSTGTNVEIRSSPTPNPSKLDDTTVLTSATA MAV_5298|M.avium_104 GLILQLPSPTVVGQVSIDTPSTGTKVEIRAASSPTPAGLNDTTVLAPAFT MLBr_02700|M.leprae_Br4923 GLMLHLPKPTVVSAVTIDVASIGTKVEIRSASTPTPAKLADTTVLIPATA MAB_4937|M.abscessus_ATCC_1997 GLLLDLQSSSALSSVTIESHSVGTQVQIRSADSATPGSINDTKEISATAT Mflv_0842|M.gilvum_PYR-GCK LKPGSNTIEVDDAEPTSYVLVWVSTLGQVGGQSRSDIAEITLNAAS Mvan_6064|M.vanbaalenii_PYR-1 VKPGSNTIEVEDAEPTSYVLVWISTLGQVDGESRSDIAEVTLNAAS MSMEG_6929|M.smegmatis_MC2_155 LKTGSNTISVGRAAPTQYLLVWISTLGTVDGKSKTDISDITVKAAS TH_2416|M.thermoresistible__bu ---------------------------------------------- Mb3940|M.bovis_AF2122/97 LRPGHNTISVEAAAPTSNLLVWISTLGTTDGKSQADISEITIYAAS Rv3910|M.tuberculosis_H37Rv LRPGHNTISVEAAAPTSNLLVWISTLGTTDGKSQADISEITIYAAS MMAR_5474|M.marinum_M LKPGSNTIAVNASSPTSNLLVWISTLGTTDGKSRSAISGLTIRAAS MUL_5063|M.ulcerans_Agy99 LKPGSNTIAVNASSPTSNLLVWISTLGTTDGKSRSAISQLTIRAAS MAV_5298|M.avium_104 LKPGHNVIPVRAGSPTSNLLVWISTLGTTNGKSQAGFSEITVQAAS MLBr_02700|M.leprae_Br4923 LKPGHNVIEVNSGSPMSNLLVWISTLGSTGGKSLAVISEITIHTPS MAB_4937|M.abscessus_ATCC_1997 LQSGKTTIPITSSSQVSHVLVWINKLGSTNGDHHAEISEITVSTAS