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M. bovis AF2122 / 97 Mb3940 (-)

annotation: transmembrane protein
coordinates: 4330558 - 4334112
length: 1184

MRPSPGEVPTASQRQPELSDAALVSHSWAMAFATLISRITGFARIVLLAAILGAALASSFSVANQLPNLV
AALVLEATFTAIFVPVLARAEQDDPDGGAAFVRRLVTLATTLLLGATTLSVLAAPLLVRLMLGTNPQVNE
PLTTAFAYLLLPQVLVYGLSSVFMAILNTRNVFGPPAWAPVVNNVVAIATLAVYLAVPGELSVDPVRMGN
AKLLVLGIGTTAGVFAQTAVLLVAIRREHISLRPLWGIDQRLKRFGAMAAAMVLYVLISQLGLVVGNRIA
STAAASGPAIYNYTWLVLMLPFGMIGVTVLTVVMPRLSRNAAADDTPAVLADLSLATRLTMITLIPTVAF
MTVGGPAIGSALFAYGNFGDVDAGYLGAAIALSAFTLIPYALVLLQLRVFYAREQPWTPITIIVVITGVK
ILGSLLAPHITGDPQLVAAYLGLANGLGFLAGTIVGYYILRRALRPDGGQLIGVGEARTALVTVAASLLA
GLLAHVADRLLGLSELTAHAGSVGSLLRLSVLALIMLPILAAVTLCARVPEARAALDAVRARIRSRRLKT
GPQTQNVLDQSSRPGPVTYPERRRLAPPRGKSVVHEPIRRRPPEQVARAGRAKGPEVIDRPSENASFGAA
SGAELPRPVADELQLDAPAGRDPGPVSRPHPSDLQNGDLPADAARGPIAFDALREPDRESSAPPDDVQLV
PGARIANGRYRLLIFHGGVPPLQFWQALDTALDRQVALTFVDPQGVLPDDVLQETLSRTLRLSRIDKPGV
ARVLDVVHTRAGGLVVAEWIRGGSLQEVADTSPSPVGAIRAMQSLAAAADAAHRAGVALSIDHPSRVRVS
IDGDVVLAYPATMPDANPQDDIRGIGASLYALLVNRWPLPEAGVRSGLAPAERDTAGQPIEPADIDRDIP
FQISAVAARSVQGDGGIRSASTLLNLMQQATAVADRTEVLGPIDEAPVSAAPRTSAPNSETYTRRRRNLL
IGIGAGAAVLMVALLVLASVLSRIFGDVSGGLNKDELGLNAPTASTSAASSAPPGSVVKPTKVTVFSPDG
GADNPGEADLAIDGNPATSWKTDIYTDPVPFPSFKNGVGLMLQLPQATVVGTVAIDVASTGTKVEIRSAS
TPTPATLEDTAVLTSATALRPGHNTISVEAAAPTSNLLVWISTLGTTDGKSQADISEITIYAAS
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb3940--100% (1184)transmembrane protein
M. bovis AF2122 / 97Mb2198pknL4e-0825.44% (283) transmembrane serine/threonine-protein kinase L

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. gilvum PYR-GCKMflv_0842-0.063.53% (1212) integral membrane protein MviN
M. tuberculosis H37RvRv3910-0.099.92% (1184) transmembrane protein
M. leprae Br4923MLBr_02700-0.075.04% (1182) hypothetical protein MLBr_02700
M. abscessus ATCC 19977MAB_4937-0.051.83% (1200) hypothetical protein MAB_4937
M. marinum MMMAR_5474-0.079.09% (1181) transmembrane protein
M. avium 104MAV_5298-0.076.92% (1196) virulence factor mvin family protein
M. smegmatis MC2 155MSMEG_6929-0.067.33% (1200) integral membrane protein MviN, putative
M. thermoresistible (build 8)TH_2416-0.076.47% (510) PROBABLE CONSERVED TRANSMEMBRANE PROTEIN
M. ulcerans Agy99MUL_5063-0.078.41% (1181) transmembrane protein
M. vanbaalenii PYR-1Mvan_6064-0.064.86% (1215) integral membrane protein MviN

CLUSTAL 2.0.9 multiple sequence alignment


Mflv_0842|M.gilvum_PYR-GCK          ---------------------------------------MPDARPEMSDR
Mvan_6064|M.vanbaalenii_PYR-1       ------------MRDAAPRRAPTRRPRSSPPPPPPPPRRPQAARPEMSDA
MSMEG_6929|M.smegmatis_MC2_155      ------------MNATQPQRPPGPRRLPRGPAP-----RRRAGQEELSDA
TH_2416|M.thermoresistible__bu      --------------------------------------------------
Mb3940|M.bovis_AF2122/97            -------------------------MRPSPGEVPTASQ----RQPELSDA
Rv3910|M.tuberculosis_H37Rv         -------------------------MRPSPGEVPTASQ----RQPELSDA
MMAR_5474|M.marinum_M               ---------------------------MPYGQAAAGPP----KRAELSDA
MUL_5063|M.ulcerans_Agy99           ---------------------------MPYGPAAAGPP----KRAELSDA
MAV_5298|M.avium_104                MNPAYRQAAPHHRRLPEPPRRPRMPGSPPTGPLPPVPAGIDRRRPELSDS
MLBr_02700|M.leprae_Br4923          --------------MKPAPRWTQSQSAQQVTHAMRPCRELSAQQPELSDA
MAB_4937|M.abscessus_ATCC_1997      ---------------------------MREPLDPLPDPEADDTIEELSDA
                                                                                      

Mflv_0842|M.gilvum_PYR-GCK          AVVSRSWGMAVATLVSRLTGFARIVLLAAILGAALSSAFTVANQLPNMIA
Mvan_6064|M.vanbaalenii_PYR-1       AVVSRSWGMALATLVSRLTGFARIVLLAAILGAALSSAFTVANQLPNMIA
MSMEG_6929|M.smegmatis_MC2_155      AVVSRSWGMAMATLISRITGFIRIVLLAAILGAALSSAFSVANQLPNLIA
TH_2416|M.thermoresistible__bu      --------------------------------------------------
Mb3940|M.bovis_AF2122/97            ALVSHSWAMAFATLISRITGFARIVLLAAILGAALASSFSVANQLPNLVA
Rv3910|M.tuberculosis_H37Rv         ALVSHSWAMAFATLISRITGFARIVLLAAILGAALASSFSVANQLPNLVA
MMAR_5474|M.marinum_M               ALVSRSWGMALATLVSRITGFARIVLLAAILGAALSSSFSVANQLPNLVA
MUL_5063|M.ulcerans_Agy99           ALVSRSWGMALATLVSRITGFARIVLLAAILGAALSSSFSVANQLPNLVA
MAV_5298|M.avium_104                ALVSRSWAMAFATLVSRLTGFARVVLLAAILGAALSSAFSVANQLPNLVA
MLBr_02700|M.leprae_Br4923          ALVSRSWAMAFATLISRITGFARVVLLAAILGAALSSAFSVANQLPNLVA
MAB_4937|M.abscessus_ATCC_1997      AVVSHSGSMAVATLVSRITGFIKLLLITAALGAASASAFSTANTLPNIIA
                                                                                      

Mflv_0842|M.gilvum_PYR-GCK          ALVLEATFTAIFVPVLARAERDDPDGGAAFIRRLLTLATALLLAVTIIST
Mvan_6064|M.vanbaalenii_PYR-1       ALVLEATFTAIFVPVLARAERDDPDGGAAFIRRLLTLATTLLLVVTIIST
MSMEG_6929|M.smegmatis_MC2_155      ALVLEATFTAIFVPVLARAERDDPDGGAAFVRRLVTLVTTLLLVTTLVSV
TH_2416|M.thermoresistible__bu      --VLEATFTAIFVPVLARAERDDPDGGTAFIRRLVTLATTLLLVTTLISV
Mb3940|M.bovis_AF2122/97            ALVLEATFTAIFVPVLARAEQDDPDGGAAFVRRLVTLATTLLLGATTLSV
Rv3910|M.tuberculosis_H37Rv         ALVLEATFTAIFVPVLARAEQDDPDGGAAFVRRLVTLATTLLLGATTLSV
MMAR_5474|M.marinum_M               ALVLEATFTAIFVPVLARAEQDDPDGGAAFVRRLVTLTTTLLIVATTLSV
MUL_5063|M.ulcerans_Agy99           ALVLEATFTAIFVPVLARAEQDDPDGGAAFVRRLVTLTTALLIVATTLSV
MAV_5298|M.avium_104                ALVLEATFTAIFVPVLARAEQSDPDGGAAFVRRLVTLTTALLIVATALSV
MLBr_02700|M.leprae_Br4923          ALVLEATFTAIFVPVLVRAERSDPDGGTAFVRQLITLTTTLLLLSTTLSV
MAB_4937|M.abscessus_ATCC_1997      ALVLEATFTAIFIPVLTRAEREDADGGEAFIRKLLTIVTTLLLVTTLLSV
                                      **********:***.***:.*.*** **:*:*:*:.*:**:  * :*.

Mflv_0842|M.gilvum_PYR-GCK          VGAPLLVNLMLGSEPLVNQPLTTAFAFLLLPQIIFYGLSSVFMAILNTRN
Mvan_6064|M.vanbaalenii_PYR-1       VAAPLLVDLMLGPDPLVDRPLTTAFAYLLLPQIIFYGLSSVFMAILNTRN
MSMEG_6929|M.smegmatis_MC2_155      AAAPALVRLMLGDDPQVNEPLTTAFAYLLLPQVLFYGLSSVFMAILNTRN
TH_2416|M.thermoresistible__bu      AAAPALTRLMLGGDPQVNEPLTTAFAYLLLPQVLFYGLSSVFMAILNTRN
Mb3940|M.bovis_AF2122/97            LAAPLLVRLMLGTNPQVNEPLTTAFAYLLLPQVLVYGLSSVFMAILNTRN
Rv3910|M.tuberculosis_H37Rv         LAAPLLVRLMLGTNPQVNEPLTTAFAYLLLPQVLVYGLSSVFMAILNTRN
MMAR_5474|M.marinum_M               LAAPLLVRLMLGRDPQVNEPLTTAFAYLLLPQVLVYGLSSVFMAILNTRN
MUL_5063|M.ulcerans_Agy99           LAAPLLVRLMLGRDPQVNEPLTTAFAYLLLPQVLVYGLSSVFIAILNTRN
MAV_5298|M.avium_104                AAAPLLVRLMLGRTPQVNEPLTVAFAYLLLPQVLAYGLTSVFMAILNTRN
MLBr_02700|M.leprae_Br4923          LAAPLLVRLMLGRNPQVNEPLTTAFAYLLLPQVLAYGLSSVFMAILNTRN
MAB_4937|M.abscessus_ATCC_1997      LAAPLLAGIMLGGDPKVNTPLTTALAYLLLPQVFFYGLSSLFMAILNTRN
                                     .** *. :***  * *: ***.*:*:*****:: ***:*:*:*******

Mflv_0842|M.gilvum_PYR-GCK          IFGPPAWAPVVNNVVAIATLGLYVLVPGELSLDPVRMGDAKLLVLGIGTT
Mvan_6064|M.vanbaalenii_PYR-1       VFGPPAWAPVVNNVVAILTLGLYVLVPGELSLNPVQMGDAKLLVLGVGTT
MSMEG_6929|M.smegmatis_MC2_155      VFGPPAWAPVLNNVVAIATLGAYLLVPGELSVDPVQMGNAKLLVLGVGTT
TH_2416|M.thermoresistible__bu      VFGPPAWAPVVNNVVAIATLGLYLLVPGELSVDPVEMGNAKLLVLGIGTT
Mb3940|M.bovis_AF2122/97            VFGPPAWAPVVNNVVAIATLAVYLAVPGELSVDPVRMGNAKLLVLGIGTT
Rv3910|M.tuberculosis_H37Rv         VFGPPAWAPVVNNVVAIATLAVYLAVPGELSVDPVRMGNAKLLVLGIGTT
MMAR_5474|M.marinum_M               VFGPPAWAPVINNVVAIATLLVYLAVPGELAIDPVKMGNAKLLVLGVGTT
MUL_5063|M.ulcerans_Agy99           VFGPPAWAPVINNGVAIATLLVYLAVPGELAVDPVKMGNAKLLVLGVGTT
MAV_5298|M.avium_104                VFGPTAWAPVVNNVVALATLAVYALVPGELSVDPVRMGNAKLLVLAVGTT
MLBr_02700|M.leprae_Br4923          VFGPPAWAPVINNIVAIAALVGYLVTPGELSVDPVRMGNAKLLVLGIGTT
MAB_4937|M.abscessus_ATCC_1997      VFGPPAWAPVWNNLVAIATLVLYWLMPGELTLDPIRMSDPKLLVLGIGTT
                                    :***.***** ** **: :*  *   ****:::*:.*.:.*****.:***

Mflv_0842|M.gilvum_PYR-GCK          LGVVAQAAVLFVAIRRERISLRPLWGIDARLKKFGMMALAMVLYVLVSQV
Mvan_6064|M.vanbaalenii_PYR-1       LGVVAQAGVLFMAIRRQRVSLRPLWGIDARLKKFGMMAVAMVLYVLISQV
MSMEG_6929|M.smegmatis_MC2_155      LGVVAQCSVLLPAIRRERISLRPLWGIDDRLKKFGAMAAAMVLYVLISQI
TH_2416|M.thermoresistible__bu      LGVVAQCGVLVVAIRRERISLRPLWGIDDRLKRFGTMAAAMVLYVLISQI
Mb3940|M.bovis_AF2122/97            AGVFAQTAVLLVAIRREHISLRPLWGIDQRLKRFGAMAAAMVLYVLISQL
Rv3910|M.tuberculosis_H37Rv         AGVFAQTAVLLVAIRREHISLRPLWGIDQRLKRFGAMAAAMVLYVLISQL
MMAR_5474|M.marinum_M               LGVFAQAAVLLVAIGRQHISLRPLWGIDDRLKRFGAMAAAMVLYVLISQL
MUL_5063|M.ulcerans_Agy99           LGVFAQAAVLLVAIGRQHISLRPLWGIDDRLKRFGAMAAAMVLYVLVSQL
MAV_5298|M.avium_104                LGVFAQTGVLLVALRRQHVDLRPLWGIDQRLKRFGTLAAAMVLYVLISQL
MLBr_02700|M.leprae_Br4923          AGAFAQTAVLLVALGREHISLHPLWGLDQRLKRFGAMATAMVLYVLISQL
MAB_4937|M.abscessus_ATCC_1997      LGVAAQAMVLLPAIRRQQIPLRPLWGLDDRLKQFGGMAAAMFAYVAISQF
                                     *. **  **. *: *::: *:****:* ***:** :* **. ** :**.

Mflv_0842|M.gilvum_PYR-GCK          GFIVGNQVASASAASGPAIYNYTWLILQLPFGIVGVTVLTVVMPRLSRNA
Mvan_6064|M.vanbaalenii_PYR-1       GFIVGNQVASTAAASGPAIYNYTWLILQLPFGIVGVTVLTVVMPRLSRNA
MSMEG_6929|M.smegmatis_MC2_155      GLVVGNQIASGAAASGPAIYNYAWLVLQLPFGMIGVTVLTVVMPRLSRNA
TH_2416|M.thermoresistible__bu      GLVVGNQIASGAAASGPAIYNYTWLVLMLPFGMIGVTVLTVVMPRLSRNA
Mb3940|M.bovis_AF2122/97            GLVVGNRIASTAAASGPAIYNYTWLVLMLPFGMIGVTVLTVVMPRLSRNA
Rv3910|M.tuberculosis_H37Rv         GLVVGNRIASTAAASGPAIYNYTWLVLMLPFGMIGVTVLTVVMPRLSRNA
MMAR_5474|M.marinum_M               GLIVGNQIASGAAASGPAIYNYTWLVLMLPFGMIGVTVLTVVMPRLSRNA
MUL_5063|M.ulcerans_Agy99           GLIVGNQIASGAAASGPAIYNYTWLVLMLPFGMIGVTVLTVVMPRLSRNA
MAV_5298|M.avium_104                GLVVGNQIASTAAASGPAIYNYTWLVLMLPFGMIGVTVLTVVMPRLSRNA
MLBr_02700|M.leprae_Br4923          GLVVTNQIASTTAASGPAIYNYTWLVLMLPFGIIGVTVLTVVMPRLSRNA
MAB_4937|M.abscessus_ATCC_1997      GYVIANRIAAGAAESGPIIYSQTWMILQLPYGVVGVTILTAIMPRLSRNA
                                    * :: *::*: :* *** **. :*::* **:*::***:**.:********

Mflv_0842|M.gilvum_PYR-GCK          ASGDGGAVLADLSLATRLTMLTLIPIVALMTVGGPAIGSALFSYGNFGAV
Mvan_6064|M.vanbaalenii_PYR-1       AADDAPAVLADLSLATRLTMITLIPIVAMMTVGGPAIGSALFSYGNFGAV
MSMEG_6929|M.smegmatis_MC2_155      AKNDIPAVLGDLSLATRLTMITLIPIVALMTVGGPAIGTALFAYGNFGRV
TH_2416|M.thermoresistible__bu      AAEDVPAVLRDFALAIRLTMVTLIPIVAVMTVGGPAIGTALFAYGNFGSV
Mb3940|M.bovis_AF2122/97            AADDTPAVLADLSLATRLTMITLIPTVAFMTVGGPAIGSALFAYGNFGDV
Rv3910|M.tuberculosis_H37Rv         AADDTPAVLADLSLATRLTMITLIPTVAFMTVGGPAIGSALFAYGNFGDV
MMAR_5474|M.marinum_M               AAEDIPAVLADLSLATRLTMITLIPTVAFMTVGGSAMGSALFAYGNFGKV
MUL_5063|M.ulcerans_Agy99           AAEDILAVLADLSLATRLTMITLIPTVAFMTVGGSAMGSALFAYGNFGKV
MAV_5298|M.avium_104                AADDTRAVLADLSLATRLTLITLIPIVAFMTVGGPAMGSALFAYGHFGDV
MLBr_02700|M.leprae_Br4923          AANDTPAMLADLSLATRLTLITLIPTVAFMTAGGSAMGSVLFAYGHFGEV
MAB_4937|M.abscessus_ATCC_1997      AAQDTPAVLGDMSLATRLTMTVLIPVVAVMTVAGPAMGPALFAYGNFHLG
                                    *  *  *:* *::** ***: .*** **.**..*.*:*..**:**:*   

Mflv_0842|M.gilvum_PYR-GCK          DAGYLGMAITLSAFTLIPYTMVLLQLRVFYAREEPWTPIVLIVVITIVKI
Mvan_6064|M.vanbaalenii_PYR-1       DAGYLGMAITLSAFTLIPYTLVLLQLRVFYAREEPWTPILLIIVITIVKI
MSMEG_6929|M.smegmatis_MC2_155      DAGYLGLAISLSAFTLIPYALVLLQLRVFYARERAWTPIIVIIVITVVKI
TH_2416|M.thermoresistible__bu      DAGYLGMAITLSAFTLIPYALVLLQLRVFYARERPWTPIIVIVVITAVKI
Mb3940|M.bovis_AF2122/97            DAGYLGAAIALSAFTLIPYALVLLQLRVFYAREQPWTPITIIVVITGVKI
Rv3910|M.tuberculosis_H37Rv         DAGYLGAAIALSAFTLIPYALVLLQLRVFYAREQPWTPITIIVVITGVKI
MMAR_5474|M.marinum_M               DAGYLGAAIALSAFTLIPYALVLLGLRVFYAREQPWTPILIIIIITSVKI
MUL_5063|M.ulcerans_Agy99           DAGYLGAAIALSAFTLIPYALVLLGLRVFYAREQPWTPILIIIIITSVKI
MAV_5298|M.avium_104                DAGYLGAAIALSAFTLIPYGLVLLQLRVFYAREQPWTPIVIILVITAVKI
MLBr_02700|M.leprae_Br4923          DAGYLGTAIVLSAFTLIPYGLVLLQLRVFYAREQPWTPIVIIVVITAVRI
MAB_4937|M.abscessus_ATCC_1997      SAHYLGLSISLSAFTLIPYALVLLQLRVFYARHEAWTPTLMIIVITAVKV
                                    .* *** :* ********* :*** *******...***  :*::** *::

Mflv_0842|M.gilvum_PYR-GCK          AASLASPHLTDDPQLVAGYLGLANGLGFLAGATVGYLLLRARLDPPGGHL
Mvan_6064|M.vanbaalenii_PYR-1       AASLAAPHLTADPQLVAGYLGLANGLGFLAGATVGYLLLRARLDPPGGRL
MSMEG_6929|M.smegmatis_MC2_155      AGSVAAPHLTNNPEMVAGYLGAANGLGFMAGAIVGHVLLRANLDPPGGRL
TH_2416|M.thermoresistible__bu      AASVAAPHLTSDPDLVAGYLGLANGLGFAAGAVVGHLLLRAHLDPPGGRL
Mb3940|M.bovis_AF2122/97            LGSLLAPHITGDPQLVAAYLGLANGLGFLAGTIVGYYILRRALRPDGGQL
Rv3910|M.tuberculosis_H37Rv         LGSLLAPHITGDPQLVAAYLGLANGLGFLAGTIVGYYILRRALRPDGGQL
MMAR_5474|M.marinum_M               GASVLAPHLTNDPDMVAGYLGLANGLGFLAGAIVGYYLLRRALRPGGGQL
MUL_5063|M.ulcerans_Agy99           GASVLAPHLTNDPDMVAGYLGLANGLGFLAGAIVGYYLLRRALCPGGGQL
MAV_5298|M.avium_104                LGSVLAPHLTGDPKLVAGFLGLANGVGFLAGAVIGYVLLRRTLLPGGGHL
MLBr_02700|M.leprae_Br4923          IVSVLAPYVISNPELVAGYLGMANGLGFAAGAIVGYYLLRRALLPTGGHL
MAB_4937|M.abscessus_ATCC_1997      IGSVAAPHLTDDPDLVAGYLGAANGLGFVAGALCGYLLLRRSLGRAAGPL
                                      *: :*::  :*.:**.:** ***:** **:  *: :**  *   .* *

Mflv_0842|M.gilvum_PYR-GCK          VSRDVVRTILVTITASLAAGLIAHIADQILGLEQLTEHWGGGGSLIRLAV
Mvan_6064|M.vanbaalenii_PYR-1       LDNAVIRTILVTITASLAAGLTAHVVDQLAGLENLTTHWGAAGSLLRLLA
MSMEG_6929|M.smegmatis_MC2_155      VSLTVVRTILVTITASLLAVLVSVVVDQLLGVEQLTVRFGAGGSMIRLVV
TH_2416|M.thermoresistible__bu      LEPAVVRTVLVTIAASLTAALIGQIADQLLGLEQLTANGGGAGSLLRLLV
Mb3940|M.bovis_AF2122/97            IGVGEARTALVTVAASLLAGLLAHVADRLLGLSELTAHAGSVGSLLRLSV
Rv3910|M.tuberculosis_H37Rv         IGVGEARTVLVTVAASLLAGLLAHVADRLLGLSELTAHAGSVGSLLRLSV
MMAR_5474|M.marinum_M               VGTREVHTILVTIAASLLAGLLAYVVDRLAGLGQLTVFGGGIGSLLRLLI
MUL_5063|M.ulcerans_Agy99           VGTREVHTILVTIAASLLAGLLAYVVDRLAGLGQLTVFDGGIGSLLRLLI
MAV_5298|M.avium_104                IGVGEVRTILVTLTAAMLAGLVAHVADRLLGLSALTAHGGGAGSLLRLLV
MLBr_02700|M.leprae_Br4923          FGVQEIRTVLVTIAASLLAGLAAHIADRLLRLNELTMHGGGAGSLLRLTV
MAB_4937|M.abscessus_ATCC_1997      IGPDVARTALVALAASVTAAAVGLGIDRGFGLDLLTQRGGGLGSILRLAI
                                    .     :* **:::*:: *   .   *:   :  **   *. **::**  

Mflv_0842|M.gilvum_PYR-GCK          LGLVMGPIILGVLIAAKVPDALAGVAAVRRRLGARG--------------
Mvan_6064|M.vanbaalenii_PYR-1       LGLVMVPIIAAVMLTAKVPEAQAALAAVRRRLGTRG--------------
MSMEG_6929|M.smegmatis_MC2_155      LGLIMLPIIAGVLIAAKVPEAQAAIRVVRGRLGRFGGKETPAVDAAEKVA
TH_2416|M.thermoresistible__bu      LGLIMAPVIAAFLWFARVPEAEAAVAAVRRRFGKTP--------------
Mb3940|M.bovis_AF2122/97            LALIMLPILAAVTLCARVPEARAALDAVRARIRSRRLKTGPQ--------
Rv3910|M.tuberculosis_H37Rv         LALIMLPILAAVTLCARVPEARAALDAVRARIRSRRLKTGPQ--------
MMAR_5474|M.marinum_M               LGVIMAPIVIAVLLAGQVPEAQAALNVVRNRIGTRLGKPGPR--------
MUL_5063|M.ulcerans_Agy99           LGVIMAPIVIAVLLAGQVPEAQAALNVVRNRIGTRLGKPGPR--------
MAV_5298|M.avium_104                LALIMVPITAAVMLRAQVPEARAALDAVRFRITGR--GPRPR--------
MLBr_02700|M.leprae_Br4923          LTSIMLPTMAVVMLRGHVPEVHAALGAVRGQIMSRNWIAKLQ--------
MAB_4937|M.abscessus_ATCC_1997      LGIVMLAVTFALMVAVKLPEALSVVAMLQRRLGGRLG-------------
                                    *  :* .    .    ::*:. : :  :: ::                  

Mflv_0842|M.gilvum_PYR-GCK          -ATTGSPVPQMSPRALTYADRSNR--------------RGPSAETADDGR
Mvan_6064|M.vanbaalenii_PYR-1       -PAAEPSVRPRPSDTLTYPDHKNRSSL-RRRQLPRSAARGPSAEAADDGR
MSMEG_6929|M.smegmatis_MC2_155      LQTNGPAVPPRTAGAVTYPDQRNSSPG-RGPTTPAPGWVGAPASVAGAGT
TH_2416|M.thermoresistible__bu      -------------------------------------ASGPAPVTAGDRR
Mb3940|M.bovis_AF2122/97            --TQNVLDQSSRPGPVTYPERRRLAPPRGKSVVHEPIRRRPPEQVARAGR
Rv3910|M.tuberculosis_H37Rv         --TQNVLDQSSRPGPVTYPERRRLAPPRGKSVVHEPIRRRPPEQVARAGR
MMAR_5474|M.marinum_M               --SVAVPDASSGDHDVTYPEQRKSSLP-GENVVQEPIRRKPP--VIRAGI
MUL_5063|M.ulcerans_Agy99           --SVAVLDPSSGDHDVTYPEQRKSSLP-GENVVQEPIRRKPP--VIRAGI
MAV_5298|M.avium_104                --KPAAPDRSSHRRPVTYPEQRNSSPP-GVNAVQEPIRRRPPERANRARL
MLBr_02700|M.leprae_Br4923          --KATVPDQSSRPITVTYPGQNNSSPP-RVNAIQESIRSRPPERIAKAQI
MAB_4937|M.abscessus_ATCC_1997      ----------------------------------ARLRAETQDHASVMGN
                                                                            .         

Mflv_0842|M.gilvum_PYR-GCK          RKGSAVSDKPTSDSPSGPDSTAPPSGPNSTAPPSGPNSTAPPSGPNSTAP
Mvan_6064|M.vanbaalenii_PYR-1       RKGFAVSDKPTSGSPGGPDSAATTR----------------------ITR
MSMEG_6929|M.smegmatis_MC2_155      RKGSPVTDESAGG--PALDGTATTK----------------------LPR
TH_2416|M.thermoresistible__bu      CTG-----------------------------------------------
Mb3940|M.bovis_AF2122/97            AKGPEVIDRPSE-NASFG-AASGA----------------------ELPR
Rv3910|M.tuberculosis_H37Rv         AKGPEVIDRPSE-NASFG-AASGA----------------------ELPR
MMAR_5474|M.marinum_M               AKGPSVTDRPSDSTASSS-SASDI----------------------DLPR
MUL_5063|M.ulcerans_Agy99           AKGPSVTDRPSDSTASSS-SASDI----------------------DLPR
MAV_5298|M.avium_104                VKGPEVTDRPMESAASSAGPGTGS----------------------GAPR
MLBr_02700|M.leprae_Br4923          AKGPEVSDRPVESASSRSASDTGLP--------------------SELPR
MAB_4937|M.abscessus_ATCC_1997      SPGPSLPYPDSGDPVGGSDAIGST-----------------------TAN
                                      *                                               

Mflv_0842|M.gilvum_PYR-GCK          PSADDFQPDVPDSYQPDPAADDSATTALP-AQGVPTQSPSKSPTETPTEA
Mvan_6064|M.vanbaalenii_PYR-1       PSPDDFQPDVPEDAGTHVLPQAPARPTGPESAARPTGPESAARPAGPESA
MSMEG_6929|M.smegmatis_MC2_155      QAPDDFQPDVADDES----EAAGAEPTVEETVSLPNGS------------
TH_2416|M.thermoresistible__bu      --AD----------------------------------------------
Mb3940|M.bovis_AF2122/97            PVADELQLDAPAG--RDPGPVSRPHPS-----------------------
Rv3910|M.tuberculosis_H37Rv         PVADELQLDAPAG--RDPGPVSRPHPS-----------------------
MMAR_5474|M.marinum_M               PVADDFQPDIPAG--PDRGRGASQRPS-----------------------
MUL_5063|M.ulcerans_Agy99           PVADDFQPDIPAG--PDRGRGASLRPS-----------------------
MAV_5298|M.avium_104                PVADDFQPDIPADQ-PDRPRKADPRPA-----------------------
MLBr_02700|M.leprae_Br4923          PVAGNSQPYISAN--LELEHVASLHPP-----------------------
MAB_4937|M.abscessus_ATCC_1997      KPAHGGGADTRKG-------------------------------------
                                      .                                               

Mflv_0842|M.gilvum_PYR-GCK          VKRPRADYSNDPTREALAFDPPREPAIETATPAEDTHLIPGATIAGGRYR
Mvan_6064|M.vanbaalenii_PYR-1       ARPPVSDYAGDPTREALPFDPPREPATEAATTAEDMHLIPGATIVDGRYR
MSMEG_6929|M.smegmatis_MC2_155      -GRPPADYGGDPTREPISFAPPREPAVESATSGDDVHLIPGATIADGRYR
TH_2416|M.thermoresistible__bu      -SQPGGDYRG------------RIPARSAFP-------VP----------
Mb3940|M.bovis_AF2122/97            -DLQNGDLPADAARGPIAFDALREPDRESSAPPDDVQLVPGARIANGRYR
Rv3910|M.tuberculosis_H37Rv         -DLQNGDLPADAARGPIAFDALREPDRESSAPPDDVQLVPGARIANGRYR
MMAR_5474|M.marinum_M               -DQSNGDS-VGYTRGPIPFDAPRERSAEPSTPQDDVNLVPGARIANGRYR
MUL_5063|M.ulcerans_Agy99           -DLSNGDS-VGYTRGPIPFDAPRECSAEPSTPQDDVNLVPGARIANGRYR
MAV_5298|M.avium_104                -DQKNGDA--GTRRG--PFDVPRERAADSSA--DDVHLVPGARIAGGRYR
MLBr_02700|M.leprae_Br4923          -EQQKVDFPAYPARRPIRFEVSRERGGEQSSPTGDVHLVPGACIAGGRYR
MAB_4937|M.abscessus_ATCC_1997      --RAVTDTPGSSTRP--------VPTQSPSTGPVPTSVMPGASIAGGRYR
                                          *                    .  .       :*          

Mflv_0842|M.gilvum_PYR-GCK          LLVSHGGPEHLQFWQATDTALDRQVALTFVAPDATMPDQQVQGILDRTQR
Mvan_6064|M.vanbaalenii_PYR-1       LLVSHGGPAHLQFWQALDTALDRQVALTFVDPDATMPDRAVQEILDRTQR
MSMEG_6929|M.smegmatis_MC2_155      LLVFHGGPPHLQFWQALDTALDRQVALTFVDPDAKLPDSQVQDILSRTLK
TH_2416|M.thermoresistible__bu      --------------------------------------------------
Mb3940|M.bovis_AF2122/97            LLIFHGGVPPLQFWQALDTALDRQVALTFVDPQGVLPDDVLQETLSRTLR
Rv3910|M.tuberculosis_H37Rv         LLIFHGGVPPLQFWQALDTALDRQVALTFVDPQGVLPDDVLQETLSRTLR
MMAR_5474|M.marinum_M               LLVFHGGIPPLQFWQALDTALDRQVALTFVDPDGTLPEDVLQEILARTLR
MUL_5063|M.ulcerans_Agy99           LLVFHGGIPPLQFWQALDTALDRQVALTFVDPDGTLPEDVLQEILARTLR
MAV_5298|M.avium_104                LLVFHGGAPPLQFWQALDTALDRQVALTFVDPDRALPDEVLQEILSRTLR
MLBr_02700|M.leprae_Br4923          LLAFHGGAPSLQFWQALDTALDRQVALTFVNPDGALPDDSLQETLSRTLR
MAB_4937|M.abscessus_ATCC_1997      LLTSHGGPDGLQFWQATDTELNRPVALTIIDG-AAFTADQVQDILSNTLR
                                                                                      

Mflv_0842|M.gilvum_PYR-GCK          LSQIDMPGVARVLDVLKTATGGLVVSEWIRGGSLAEVAATNPSPIGGARA
Mvan_6064|M.vanbaalenii_PYR-1       LSRIDMPGVARVLDVVSTGVGGLVVSEWIRGGSLAEVADTCPSPIGGARA
MSMEG_6929|M.smegmatis_MC2_155      LSRLDVPGIARVLDVAHSGSGGLIVSEWIRGGSLAEVADTAPSPIGGARA
TH_2416|M.thermoresistible__bu      --------------------------------------------------
Mb3940|M.bovis_AF2122/97            LSRIDKPGVARVLDVVHTRAGGLVVAEWIRGGSLQEVADTSPSPVGAIRA
Rv3910|M.tuberculosis_H37Rv         LSRIDKPGVARVLDVVHTRAGGLVVAEWIRGGSLQEVADTSPSPVGAIRA
MMAR_5474|M.marinum_M               LSRIDKPGVARVLDVLHTASGGLVVSEWIRGGSLQEVADTAPSPVGAIRA
MUL_5063|M.ulcerans_Agy99           LSRIDKPGVARVLDVLHTASGGLVVSEWIRGGSLQEVADTAPSPVGAIRA
MAV_5298|M.avium_104                LSRIDKPGIARVLDVVHTGSGGLVVSEWIRGGSLQEVADTAPSPVGAVRA
MLBr_02700|M.leprae_Br4923          LSRIDMPGVAQVLDVIHTGSGGLVVSEWIRGGSLHEVADTSPSPVGAIRA
MAB_4937|M.abscessus_ATCC_1997      LSKIESSGLARVLDAVHEGNGGIVVAQWVRGGSLREVADTEPSAVGASRA
                                                                                      

Mflv_0842|M.gilvum_PYR-GCK          IQSLAAAAEVAHRNGVALSIDHPSRIRVSIDGDVALAFPATLPDATPDDD
Mvan_6064|M.vanbaalenii_PYR-1       IQSLAAAAEVAHRNGVALSIDHPSRIRVSIDGDVALAFPATLPDASPDDD
MSMEG_6929|M.smegmatis_MC2_155      IQSLAAAAEAAHRAGVALSIDHPSRVRVSIEGDVALAFPATLPDATPDDD
TH_2416|M.thermoresistible__bu      --------------------------------------------------
Mb3940|M.bovis_AF2122/97            MQSLAAAADAAHRAGVALSIDHPSRVRVSIDGDVVLAYPATMPDANPQDD
Rv3910|M.tuberculosis_H37Rv         MQSLAAAADAAHRAGVALSIDHPSRVRVSIDGDVVLAYPATMPDANPQDD
MMAR_5474|M.marinum_M               MQSLAAAADAAHRAGVALSLDHPGRVRVSIEGDVVLAYPATMPDANPQDD
MUL_5063|M.ulcerans_Agy99           IQSLAAAADAAHRAGVALSLDHPGRVRVSIEGDVVLAYPATMPDANPQDD
MAV_5298|M.avium_104                MQSLAAAADAAHRAGVALSIDHPSRVRVSIEGDVVLAYPATMPDANPQDD
MLBr_02700|M.leprae_Br4923          MQSLAAAADAAHRAGVALSIDHPSRVRVSTEGDVVLAYPATMPDANHHTD
MAB_4937|M.abscessus_ATCC_1997      VRSLAEAADAAFEAGSALSIDHPDRVRISIDGDAVLAFPATLSSASADED
                                                                                      

Mflv_0842|M.gilvum_PYR-GCK          IRGIGASLYALLINRWPLPETGEPSGLAPAELDAAGQPAEPRSIDRDIPF
Mvan_6064|M.vanbaalenii_PYR-1       IRGIGASLYALLVNRWPLPETGEPSGLAPADLDAAGQPVEPRSVDRDIPF
MSMEG_6929|M.smegmatis_MC2_155      IRGIGAALYALLVNRWPLPESGEPSGLEPAALDAAGQPVEPRAVDRDIPF
TH_2416|M.thermoresistible__bu      --------------------------------------------------
Mb3940|M.bovis_AF2122/97            IRGIGASLYALLVNRWPLPEAGVRSGLAPAERDTAGQPIEPADIDRDIPF
Rv3910|M.tuberculosis_H37Rv         IRGIGASLYALLVNRWPLPEAGVRSGLAPAERDTAGQPIEPADIDRDIPF
MMAR_5474|M.marinum_M               IRGIGAALYALLVNRWPLPEAGADSGFAPAERDASGNPVEPAAVDRDIPF
MUL_5063|M.ulcerans_Agy99           IRGIGAALYALLVNRWPLPEAGADSGFAPAERDASGNPVEPAAVDRDIPF
MAV_5298|M.avium_104                IRGIGAALYALLVNRWPLAESGVRSGLAPAERDSSGNPVEPMAIDRDIPF
MLBr_02700|M.leprae_Br4923          IRGIGATLYALLVNRWPLPEAGMHSGLAPAQQDTTGQPVEPAVIDQNIPT
MAB_4937|M.abscessus_ATCC_1997      VRGLGAALYALTTRRWPLAETGQPSGLPAANRAPDGRPVEARVLIPTVPA
                                                                                      

Mflv_0842|M.gilvum_PYR-GCK          QISAAAAHAVQEGGGIRSAPTLLNLLQQATAIADRTDHISPVDEP-----
Mvan_6064|M.vanbaalenii_PYR-1       QISAAAAHAVQEGGGIRSAPTLLNLLQQATAIADRTDHIAPVDDP-----
MSMEG_6929|M.smegmatis_MC2_155      QISAAAARAVQPGGGIRSAPTLLNLLQQATAIADRTELLESVEQT-----
TH_2416|M.thermoresistible__bu      --------------------------------------------------
Mb3940|M.bovis_AF2122/97            QISAVAARSVQGDGGIRSASTLLNLMQQATAVADRTEVLGPIDE------
Rv3910|M.tuberculosis_H37Rv         QISAVAARSVQGDGGIRSASTLLNLMQQATAVADRTEVLGPIDE------
MMAR_5474|M.marinum_M               QISAVTVRSVQEDGGIRSASTLLNLLQQATAVADRTEVLGPIEP------
MUL_5063|M.ulcerans_Agy99           QISAVTVRSVQEDGGIRSASTLLNLLQQATAVADRTEVLGPIEP------
MAV_5298|M.avium_104                QISAVAVRAVQDDGGIRSASTLLNLLQQATAVADRTEVLGPIDD------
MLBr_02700|M.leprae_Br4923          QISAVTVRAVQEDGGILRASTLLNLLQQATAVADRTEVLSPIDDR-----
MAB_4937|M.abscessus_ATCC_1997      EISDVAARALSDDPG--SAAELLDGLESAIASVDHTTMLEPAAAAPTQAL
                                                                                      

Mflv_0842|M.gilvum_PYR-GCK          ---------SPAAVADTSWSADPEDAEEAAARRRRNLTIGLSVAGVIVVV
Mvan_6064|M.vanbaalenii_PYR-1       ---------APPPSG-AGFAAELD--PEAAARRRKGLIVGLSVAGAIAVI
MSMEG_6929|M.smegmatis_MC2_155      ----------PAAAAATPHTDGAD----AEARRRRALIVGLSAGAAIIVV
TH_2416|M.thermoresistible__bu      --------------------------------------------------
Mb3940|M.bovis_AF2122/97            ---------APVSAAPRTSAPNS----ETYTRRRRNLLIGIGAGAAVLMV
Rv3910|M.tuberculosis_H37Rv         ---------APVSAAPRTSAPNS----ETYTRRRRNLLIGIGAGAAVLMV
MMAR_5474|M.marinum_M               ---------PAPPAPARSPAPTG----ATFGRRRRNLLIGIGAGAAILLV
MUL_5063|M.ulcerans_Agy99           ---------PAPPAPARSPAPTG----ATFGRRSRNLLIGIGAGAAILLV
MAV_5298|M.avium_104                ---------SPSPSTALISPGNDP---ATFARRRRNVLIGVGAGLAVLVA
MLBr_02700|M.leprae_Br4923          ---------SPTPTAFCPTTARDP---VVFAQRRRNLLIGIGAAVVILVV
MAB_4937|M.abscessus_ATCC_1997      DVGRRPSFEDPADSDDEDYEDYEEEDPEEAARHRKIFLIGLGVVGVLVIS
                                                                                      

Mflv_0842|M.gilvum_PYR-GCK          AVILLATVLSRIFGDVGSGLGGDELGLNAPSSSQTDSPS---TATGSALE
Mvan_6064|M.vanbaalenii_PYR-1       AVVLLATVLSRIFGDVGDGLGGDELGLNSPSSSTTAQP----GQSGSALK
MSMEG_6929|M.smegmatis_MC2_155      ALVVMATILSRIFGDVGGGINRDQLGLNAPSSETESEGGD-TAAAGATVK
TH_2416|M.thermoresistible__bu      --------------------------------------------------
Mb3940|M.bovis_AF2122/97            ALLVLASVLSRIFGDVSGGLNKDELGLNAPTASTSAASS---APPGSVVK
Rv3910|M.tuberculosis_H37Rv         ALLVLASVLSRIFGDVSGGLNKDELGLNAPTASTSAASS---APPGSVVK
MMAR_5474|M.marinum_M               ALLVLASVLNKMFGNVGGGLDRDQLGLNAPTASTSAAASS--APAGSVVK
MUL_5063|M.ulcerans_Agy99           ALLVLASVLNKMFGNVGGGLDQDQLGLNAPTASTSAAASS--ASAGSVVK
MAV_5298|M.avium_104                ALLVLASIVSKIFGNVGGGLNKDELGLNGPSSSTSAPQTTTSAAAGSVVK
MLBr_02700|M.leprae_Br4923          ALLVMASVINKVFGHLGSGLNNDKLGLNTPTSSTSSSPTS-SVPEGSIVK
MAB_4937|M.abscessus_ATCC_1997      LCIALGVWVTRIFGDVGP-LDKINIGIGLPTQSSGGDAAK----PGSPAK
                                                                                      

Mflv_0842|M.gilvum_PYR-GCK          PVRATVFSPEGEADAPDAASLAIDGDPSTVWPIDTYTDPVPFPN-FKNGV
Mvan_6064|M.vanbaalenii_PYR-1       PVSVTVFSPEGEADAPKLAGLAIDGNPATVWPIDTYTDAAPFPN-FKNGV
MSMEG_6929|M.smegmatis_MC2_155      PVRATVFSPEGEADNPGQAELAIDGSSSTMWSTDTYSDPVPFPG-FKNGV
TH_2416|M.thermoresistible__bu      --------------------------------------------------
Mb3940|M.bovis_AF2122/97            PTKVTVFSPDGGADNPGEADLAIDGNPATSWKTDIYTDPVPFPS-FKNGV
Rv3910|M.tuberculosis_H37Rv         PTKVTVFSPDGGADNPGEADLAIDGNPATSWKTDIYTDPVPFPS-FKNGV
MMAR_5474|M.marinum_M               PTKATVFSPDGEADNPGQADMAIDGDSTTSWETDTYNDPVPFPG-FKNGV
MUL_5063|M.ulcerans_Agy99           PTKATVFSPDGEADNPGQADMAIDGDSTTSWETDTYNDPVPFPG-FKNGV
MAV_5298|M.avium_104                PTRASVFSLDGDADNPGTAGQAIDGDPSTAWATEVYTDAVPFPS-FKQGE
MLBr_02700|M.leprae_Br4923          PTKATVFSPDGEADNPDDAGLAIDGNPATSWQTDIYNDAVPFPG-FKNGV
MAB_4937|M.abscessus_ATCC_1997      IVQATVFPPGPDADQPGKAGLAVDGNPSTSWITDTYTDADPFPVLFKPGV
                                                                                      

Mflv_0842|M.gilvum_PYR-GCK          GLMLQLSEPARIGSVTVNLNSTGTAVQIRSSSTATPSSLEDTTALTEPTT
Mvan_6064|M.vanbaalenii_PYR-1       GLMLQLPEPAKIGSVTVNLNSTGTSVQIRSSETATPSSLEDTTALTDPTP
MSMEG_6929|M.smegmatis_MC2_155      GLILQLPQPTVIGSVDLNVTSTGTAVQLRAANSNSPSSLSDTTELTSPTT
TH_2416|M.thermoresistible__bu      --------------------------------------------------
Mb3940|M.bovis_AF2122/97            GLMLQLPQATVVGTVAIDVASTGTKVEIRSASTPTPATLEDTAVLTSATA
Rv3910|M.tuberculosis_H37Rv         GLMLQLPQATVVGTVAIDVASTGTKVEIRSASTPTPATLEDTAVLTSATA
MMAR_5474|M.marinum_M               GLMLQLPQPTVVGSVTLDVPSTGTKVEIRSSPTPNPSKLDDTTVLTSATA
MUL_5063|M.ulcerans_Agy99           GLVLQLPQPTVVGSVTLDVPSTGTNVEIRSSPTPNPSKLDDTTVLTSATA
MAV_5298|M.avium_104                GLILQLPSPTVVGQVSIDTPSTGTKVEIRAASSPTPAGLNDTTVLAPAFT
MLBr_02700|M.leprae_Br4923          GLMLHLPKPTVVSAVTIDVASIGTKVEIRSASTPTPAKLADTTVLIPATA
MAB_4937|M.abscessus_ATCC_1997      GLLLDLQSSSALSSVTIESHSVGTQVQIRSADSATPGSINDTKEISATAT
                                                                                      

Mflv_0842|M.gilvum_PYR-GCK          LKPGSNTIEVDDAEPTSYVLVWVSTLGQVGGQSRSDIAEITLNAAS
Mvan_6064|M.vanbaalenii_PYR-1       VKPGSNTIEVEDAEPTSYVLVWISTLGQVDGESRSDIAEVTLNAAS
MSMEG_6929|M.smegmatis_MC2_155      LKTGSNTISVGRAAPTQYLLVWISTLGTVDGKSKTDISDITVKAAS
TH_2416|M.thermoresistible__bu      ----------------------------------------------
Mb3940|M.bovis_AF2122/97            LRPGHNTISVEAAAPTSNLLVWISTLGTTDGKSQADISEITIYAAS
Rv3910|M.tuberculosis_H37Rv         LRPGHNTISVEAAAPTSNLLVWISTLGTTDGKSQADISEITIYAAS
MMAR_5474|M.marinum_M               LKPGSNTIAVNASSPTSNLLVWISTLGTTDGKSRSAISGLTIRAAS
MUL_5063|M.ulcerans_Agy99           LKPGSNTIAVNASSPTSNLLVWISTLGTTDGKSRSAISQLTIRAAS
MAV_5298|M.avium_104                LKPGHNVIPVRAGSPTSNLLVWISTLGTTNGKSQAGFSEITVQAAS
MLBr_02700|M.leprae_Br4923          LKPGHNVIEVNSGSPMSNLLVWISTLGSTGGKSLAVISEITIHTPS
MAB_4937|M.abscessus_ATCC_1997      LQSGKTTIPITSSSQVSHVLVWINKLGSTNGDHHAEISEITVSTAS