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PQERELPLPQRRRRGARRAEDLPVRSWLKLGAASAGLGAALLGFALAGPSPMAEADTGTETSVSTGPEKA TAEQSGSGEADAPDDAEDEANEDSDELDDADATDDPDDPDDADATDDVDDVDEADDAVGEATDGDRDDEG GEAAAGGADPAADGDVVTDLPALVESPPPTENSGATTESAASAQPATPKRPWRELVAGFIDDWTADTEAW IDSLDASDQTKERLEATFWAVRRTFFNQAPTVDPVQITGVITGPVTGTLGAVDPDGDRVVYRLVRAPGQG SVKVNSDGTFTYTPGSDFDGVDTFRVLAVDVGMHVNVLDWFRPWGTRATPLINQGAVTFDFRYETGAGHW SAERKAALLGAANELVSYLRVNAPVVISYRVDGFDDPTSALLAQAGSSYTSAEPGFWPTLVQNKLISGGD ANGSAADGLIQVNFGKKWSLDDTVESDEFDFMMALMHEMLHSFGILFAVRPGETTRRYWSTYASLVVDEN GSSPFNSDFSWNTAYDPNLTRKDGGLFFGGTEAVEAYDGALIPLFTSDPWLGTSVGAHLDDMVFIGVDRK MMNASTTPGPGVRVLSAIELGILKDLGYQVVARTPVEDLA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_6043 | - | - | 100% (601) | hypothetical protein Mvan_6043 |
| M. vanbaalenii PYR-1 | Mvan_3789 | - | 4e-25 | 30.06% (316) | peptidase M4, thermolysin |
| M. vanbaalenii PYR-1 | Mvan_2332 | - | 5e-25 | 31.06% (322) | hypothetical protein Mvan_2332 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2471c | rne | 1e-07 | 29.67% (182) | ribonuclease E |
| M. gilvum PYR-GCK | Mflv_0864 | - | 1e-148 | 48.12% (584) | hypothetical protein Mflv_0864 |
| M. tuberculosis H37Rv | Rv2444c | rne | 1e-07 | 29.67% (182) | ribonuclease E |
| M. leprae Br4923 | MLBr_01468 | - | 3e-05 | 31.25% (112) | putative ribonuclease |
| M. abscessus ATCC 19977 | MAB_3669 | - | 5e-06 | 40.23% (87) | hypothetical protein MAB_3669 |
| M. marinum M | MMAR_3768 | rne | 2e-09 | 34.21% (114) | ribonuclease E Rne |
| M. avium 104 | MAV_1728 | - | 3e-08 | 27.17% (184) | Rne protein |
| M. smegmatis MC2 155 | MSMEG_4626 | - | 8e-08 | 29.29% (140) | ribonuclease, Rne/Rng family protein |
| M. thermoresistible (build 8) | TH_0997 | rne | 2e-09 | 29.61% (152) | POSSIBLE RIBONUCLEASE E RNE |
| M. ulcerans Agy99 | MUL_3715 | rne | 1e-10 | 31.97% (122) | ribonuclease E Rne |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2471c|M.bovis_AF2122/97 MIDGAPPSDPP-EPSQHEELPDRLRVHSLARTLGTTSRRVLDALTALDGR
Rv2444c|M.tuberculosis_H37Rv MIDGAPPSDPP-EPSQHEELPDRLRVHSLARTLGTTSRRVLDALTALDGR
MLBr_01468|M.leprae_Br4923 MIDGAPPLEPSKEPTQHMELPDRLRVHSLARTLGTTSRRVLDVLSALDGR
MMAR_3768|M.marinum_M MVDGAPSSDPENEPTQREDLPDRLRVHSLARTLGTSSRRVLDALSALDGR
MUL_3715|M.ulcerans_Agy99 MVDGAPSSDPENEPTQREDLPDRLRVHSLARTLGTSSRRVLDALSALDGR
MAV_1728|M.avium_104 MVDGAPTADPSEESTRSGDLPDRLRVHSLARTLGTTSKRVLDALSELDGR
MSMEG_4626|M.smegmatis_MC2_155 MAEDAHTEDLSTQTPQQEGLPERLRVHSLARVLGTTSRRVLDALAEFDGR
TH_0997|M.thermoresistible__bu --------------------------------------------------
Mvan_6043|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_0864|M.gilvum_PYR-GCK --------------------------------------------------
MAB_3669|M.abscessus_ATCC_1997 --------------------------------------------------
Mb2471c|M.bovis_AF2122/97 VRSAHSTVDRVDAVRVRDLLATHLETAG----------------------
Rv2444c|M.tuberculosis_H37Rv VRSAHSTVDRVDAVRVRDLLATHLETAG----------------------
MLBr_01468|M.leprae_Br4923 IRSAHSSVDRVDAVRVRDLLASQPNSPH----------------------
MMAR_3768|M.marinum_M IRSAHSSVDRVDAVRVRDLLAEQPAEEGQAEEGQQAPD------------
MUL_3715|M.ulcerans_Agy99 IRSAHSSVDRVDAVRVRDLLAEQPAEEGQAEEDQQAPD------------
MAV_1728|M.avium_104 VRSAHSTVDREDAVRVRDLLAAQPSAELEP--------------------
MSMEG_4626|M.smegmatis_MC2_155 QRSAHSTVDKADAERVRAALTESPAAETPPEEAPAAETPVADLVVVQAEQ
TH_0997|M.thermoresistible__bu --------------------------------------------------
Mvan_6043|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_0864|M.gilvum_PYR-GCK --------------------------------------------------
MAB_3669|M.abscessus_ATCC_1997 --------------------------------------------------
Mb2471c|M.bovis_AF2122/97 --------------VLAASVHAPEA--SEEP-------------------
Rv2444c|M.tuberculosis_H37Rv --------------VLAASVHAPEA--SEEP-------------------
MLBr_01468|M.leprae_Br4923 --------------ELTAVPDNPVA--LEER-------------------
MMAR_3768|M.marinum_M -------------AVAAEVPDAPGE--PAEPD------------------
MUL_3715|M.ulcerans_Agy99 -------------AVAAEVPDAPGE--PAEP-------------------
MAV_1728|M.avium_104 -------------AAEDAASGGPDAGITGEP-------------------
MSMEG_4626|M.smegmatis_MC2_155 VEVVTVSEAGPAEPAEPAEPEAPAAEAEAEAETEVADEAETPEPTFRGAV
TH_0997|M.thermoresistible__bu --------------------------------------------------
Mvan_6043|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_0864|M.gilvum_PYR-GCK --------------------------------------------------
MAB_3669|M.abscessus_ATCC_1997 --------------------------------------------------
Mb2471c|M.bovis_AF2122/97 ------ESRLMLETQE---TRNADVERPHYMPLFVAPQPIPEPLADDEDV
Rv2444c|M.tuberculosis_H37Rv ------ESRLMLETQE---TRNADVERPHYMPLFVAPQPIPEPLADDEDV
MLBr_01468|M.leprae_Br4923 ------DSRLVLET---------TVERPHYMPLFVAPQPI--EVDDDSCA
MMAR_3768|M.marinum_M ----EPESRLMLETQETVQVVETWVERPHYMPLFVAPQPISEPVAGDDAD
MUL_3715|M.ulcerans_Agy99 ------ESRLMLETQETVQVVETWVERPHYMPLFVAPQPISEPVAGDDAD
MAV_1728|M.avium_104 ------ESRLLLETPD-------ATERPHYMPLFVAPQPLE-SSDDDGDA
MSMEG_4626|M.smegmatis_MC2_155 LVGDEPESRLILEHANIPPARETQTERPDYLPLFVAPQPVSFEPAVVDDE
TH_0997|M.thermoresistible__bu --------------------------------------------------
Mvan_6043|M.vanbaalenii_PYR-1 -----------------------------------MPQERELPLPQRRRR
Mflv_0864|M.gilvum_PYR-GCK -------------------------------------------MSTHTHR
MAB_3669|M.abscessus_ATCC_1997 --------------------------------------------------
Mb2471c|M.bovis_AF2122/97 DDGPDYVADDS--------DADDEGQLDRPANRRRRRGRRGRGRGRGEQG
Rv2444c|M.tuberculosis_H37Rv DDGPDYVADDS--------DADDEGQLDRPANRRRRRGRRGRGRGRGEQG
MLBr_01468|M.leprae_Br4923 DDDVESGDDSD--------VGDDEEQPDRPANRRRRRGRRGRGRGRGEQG
MMAR_3768|M.marinum_M DESGDEGDD-------------DEEQADRPANRRRRRGRRGRGRGRGEQG
MUL_3715|M.ulcerans_Agy99 DESGDEGDD-------------DEEQADRPGNRRRRRGRRGRGRGRGEQG
MAV_1728|M.avium_104 DETADSDDSD----------GDDDEQADRPSSRRRRRGRRGRGRGRGEQG
MSMEG_4626|M.smegmatis_MC2_155 DEDDDTETGAESDFDSGADSDSDDDQADRP--RRRRRGRRGRGRGRGEQN
TH_0997|M.thermoresistible__bu --------------------------------------------------
Mvan_6043|M.vanbaalenii_PYR-1 G---------------------ARRAEDLPVRSWLKLGAASAGLGAALLG
Mflv_0864|M.gilvum_PYR-GCK R---------------------ARRSEAFAVRRWLHAGAVTAGMGAALLG
MAB_3669|M.abscessus_ATCC_1997 --------------------------------------------------
Mb2471c|M.bovis_AF2122/97 GSDGDPVDQQSEPRAQQFTSADAAETDDGDDRDSEDTEAGDNGEDENGSL
Rv2444c|M.tuberculosis_H37Rv GSDGDPVDQQSEPRAQQFTSADAAETDDGDDRDSEDTEAGDNGEDENGSL
MLBr_01468|M.leprae_Br4923 GSDVQSDDVDG--------AVDSTESEDFDGQDFDESEDTEIGYDESGSS
MMAR_3768|M.marinum_M ANDGQDQPGDDGDEAPQKTGGNSTSSDDTEAQDGADSEESDNGDDDNGSA
MUL_3715|M.ulcerans_Agy99 ANDGQDQPGDDGDEAPQKAGGNSTSSDDSEAQDGADSEESDNGDDDNGSA
MAV_1728|M.avium_104 GSDGPGDGDNDEPQNRGKKGGQSDGDDDSDGQDAEDADDSDTGDD--GSA
MSMEG_4626|M.smegmatis_MC2_155 DDATSD------------ADTDSTEDQTDGDEQESGEDSDDSGDEDSTTT
TH_0997|M.thermoresistible__bu --------------------------------------------------
Mvan_6043|M.vanbaalenii_PYR-1 --------------------FALAGPSPMAEADTGTETSVSTGPEKATAE
Mflv_0864|M.gilvum_PYR-GCK --------------------FGVLAETATAAADPGSE-SASAGATNAGPS
MAB_3669|M.abscessus_ATCC_1997 --------------------------------------------------
Mb2471c|M.bovis_AF2122/97 EAGNRRRRRRRRRKSASGDDNDAALEGPLPDDPPNTVVHERVPRAGDKAG
Rv2444c|M.tuberculosis_H37Rv EAGNRRRRRRRRRKSASGDDNDAALEGPLPDDPPNTVVHERVPRAGDKAG
MLBr_01468|M.leprae_Br4923 EAGNRRRRRRRRRKSGVGED-----EGCAPDDPPNTVVHERTPRAAGRSA
MMAR_3768|M.marinum_M DGANRRRRRRRRRKSGAGDDGD---EGPAPDDPPNTVVHERAPRSGGKSG
MUL_3715|M.ulcerans_Agy99 DGASRRRRRRRRRKSGAGDDGD---EGPAPDDPPNTVVHERAPRSGDKSG
MAV_1728|M.avium_104 DGGNRRRRRRRRRKSGSGDDNE---DGPSPDDPPNTVVHERPPRNGKNGG
MSMEG_4626|M.smegmatis_MC2_155 EGGTRRRRRRRRRKSGSGDSDD----AVSPDDPPNTVVHERAPRTER---
TH_0997|M.thermoresistible__bu ---------------------------VSPDDPPNTVVHERVPRTEK---
Mvan_6043|M.vanbaalenii_PYR-1 QSGSGEADAPDDAEDEANEDSDELDDADATDDPDDPDDADATDDVDD---
Mflv_0864|M.gilvum_PYR-GCK AGEDGGSTAPDAAT-----DADAATDADETDD----AAADADETADD---
MAB_3669|M.abscessus_ATCC_1997 ------------------------------------MAADIVP-------
:
Mb2471c|M.bovis_AF2122/97 NSQD--GGSGSTEIKGIDGSTRLEAKRQRRRDGRDAGRRRPPVLSEAEFL
Rv2444c|M.tuberculosis_H37Rv NSQD--GGSGSTEIKGIDGSTRLEAKRQRRRDGRDAGRRRPPVLSEAEFL
MLBr_01468|M.leprae_Br4923 SFDNGVNGTGSADIKGIDGSTRLEAKRQRRRDGRDAGRRRSSVLSEAEFL
MMAR_3768|M.marinum_M NSDSG-DDSGGNEIKGIDGSTRLEAKRQRRRDGRDAGRRRPPVLSEAEFL
MUL_3715|M.ulcerans_Agy99 NSDSG-DDSGGNEIKGIDGSTRLEAKRQRRRDGRDAGRRRPPVLSEAEFL
MAV_1728|M.avium_104 DDGN---GSSSSEIKGIDGSTRLEAKRQRRRDGRDAGRRRPPVLTEAEFL
MSMEG_4626|M.smegmatis_MC2_155 SDKS-----DDSEIQGISGSTRLEAKRQRRRDGRDAGRRRPPILSEAEFL
TH_0997|M.thermoresistible__bu EERDQ----AHSEIQGITGSTRLEAKRQRRRDGRDAGRRRPPILSEAEFL
Mvan_6043|M.vanbaalenii_PYR-1 -------------VDEADDAVGEATDGDRDDEGGEAAAGGADPAADGDVV
Mflv_0864|M.gilvum_PYR-GCK -------------DEAADDAAAEEPDAEPVAVKPSTHRTKADTAVEAAVA
MAB_3669|M.abscessus_ATCC_1997 ---------------IELGLTEGDVVTLWAPRWRDAGDEWEAFLGKDDDL
. . .: .
Mb2471c|M.bovis_AF2122/97 ARREAVERVMVVRDRVRTEPPLPGTRYTQIAVLEDGIVVEHFVTSAASAS
Rv2444c|M.tuberculosis_H37Rv ARREAVERVMVVRDRVRTEPPLPGTRYTQIAVLEDGIVVEHFVTSAASAS
MLBr_01468|M.leprae_Br4923 ARRESVERVMVVRDRIRTEPPHPGARYTQIAVLEDGIVVEHFVTSAASAS
MMAR_3768|M.marinum_M ARREAVERVMVVRDRVRTEPPHPGSRYTQIAVLEDGIVVEHFVTSAASAS
MUL_3715|M.ulcerans_Agy99 ARREAVERVMVVRDRVRTEPPHPGSRYTQIAVLEDGIVVEHFVTSAASAS
MAV_1728|M.avium_104 ARREAVERVMVVRDRIRTEPPHQGSRYTQIAVLEDGIVVEHFVTSAASAS
MSMEG_4626|M.smegmatis_MC2_155 ARREAVERTMIVRDKVRTEPPHEGARYTQIAVLEDGVVVEHFVTSAASAS
TH_0997|M.thermoresistible__bu ARREAVERVMVVRDKVRTEPPHQGARYTQIAVLEDGVVVEHFVTSSASAS
Mvan_6043|M.vanbaalenii_PYR-1 TDLPALVESPPPTENSGATTESAASAQPATPKRPWRELVAGFIDDWTADT
Mflv_0864|M.gilvum_PYR-GCK EQVSSTALP-----GRAATQPPYVSEQSAYEKR-----VAESLAAWTQRN
MAB_3669|M.abscessus_ATCC_1997 YVFESVADLVAFVRTDNDNDLVDHPAWSTLASLSADELEPDDDNRYDLIG
: . .
Mb2471c|M.bovis_AF2122/97 LVGNIYLGIVQNVLPSMEAAFVDIGR-GRNGVLYAGEVNWDAAGLGGADR
Rv2444c|M.tuberculosis_H37Rv LVGNIYLGIVQNVLPSMEAAFVDIGR-GRNGVLYAGEVNWDAAGLGGADR
MLBr_01468|M.leprae_Br4923 LVGNIYLGIVQNVLPSMEAAFVDIGR-GRNGVLYAGEVNWEAAGLGGADR
MMAR_3768|M.marinum_M LVGNIYLGIVQNVLPSMEAAFVDIGR-GRNGVLYAGEVNWDAAGLGGADR
MUL_3715|M.ulcerans_Agy99 LVGNIYLGIVQNVLPSMEAAFVDIGR-GRNGVLYAGEVNWDAAGLGGADR
MAV_1728|M.avium_104 LVGNIYLGIVQNVLPSMEAAFVDIGR-GRNGVLYAGEVNWEAAGLGGSDR
MSMEG_4626|M.smegmatis_MC2_155 LVGNIYLGIVQNVLPSMEAAFVDIGR-GRNGVLYAGEVNWEAAGLGGQNR
TH_0997|M.thermoresistible__bu LVGNIYLGIVQNVLPSMEAAFVDIGR-GRNGVLYAGEVNWEAAGLGGQNR
Mvan_6043|M.vanbaalenii_PYR-1 EAWIDSLDASDQTKERLEATFWAVRRTFFNQAPTVDPVQITGVITGPVTG
Mflv_0864|M.gilvum_PYR-GCK QEWVDSLDVTDERKERMQESFVAMRTTFFNQAPTIAPVQITGVITGPVTG
MAB_3669|M.abscessus_ATCC_1997 VPELVADKPTEDAVDTLRATLAIVAS------------IGAVCELAPINK
:: :. :: : .
Mb2471c|M.bovis_AF2122/97 KIEQALKPGDYVVVQVSKDPVGHKGARLTTQVSLAGRFLVYVPGASSTGI
Rv2444c|M.tuberculosis_H37Rv KIEQALKPGDYVVVQVSKDPVGHKGARLTTQVSLAGRFLVYVPGASSTGI
MLBr_01468|M.leprae_Br4923 KIEQALKPGDYIVVQVNKDPVGHKGARLTTQVSLAGRYLVYVPGASSTGI
MMAR_3768|M.marinum_M KIEQALKPGDYIVVQVSKDPVGHKGARLTTQVSLAGRYLVYVPGASSTGI
MUL_3715|M.ulcerans_Agy99 KIEQALKPGDYIVVQVSKDPVGHKGARLTTQVSLAGRYLVYVAGASSTGI
MAV_1728|M.avium_104 KIEQALKPGDYVVVQVSKDPVGHKGARLTTQVSLAGRYLVYVPGASSTGI
MSMEG_4626|M.smegmatis_MC2_155 KIEQALKPGDYVVVQVSKDPVGHKGARLTTQVSLAGRYLVYVPGASSTGI
TH_0997|M.thermoresistible__bu KIEQALKPGDYVVVQVSKDPVGHKGARLTTQLSLAGRYLVYVPGATSTGI
Mvan_6043|M.vanbaalenii_PYR-1 TLGAVDPDGDRVVYRLVRAPG-----QGSVKVNSDG-TFTYTPGSDFDGV
Mflv_0864|M.gilvum_PYR-GCK TIGAIDPDGDRLRYVITRAPA-----TGTVKINVDG-TYTYTPGAEFDGV
MAB_3669|M.abscessus_ATCC_1997 LINGNP-----------------------------------VLGTLSGGA
: . *: *
Mb2471c|M.bovis_AF2122/97 SR-KLPDTERQRLKEILREVVPSDAGVIIRTASEGVKEDDIRADVARLRE
Rv2444c|M.tuberculosis_H37Rv SR-KLPDTERQRLKEILREVVPSDAGVIIRTASEGVKEDDIRADVARLRE
MLBr_01468|M.leprae_Br4923 SR-KLPDTERQRLKEILREVVPPDAGVIIRTASEGVKEEDIRKDVTRLQE
MMAR_3768|M.marinum_M SR-KLPDTERQRLKEILREVVPSDAGVIIRTASEGVKEDDIRADVTRLQE
MUL_3715|M.ulcerans_Agy99 SR-KLPDTERQRLKEILREVVPSDAGVIIRTASEGVKEDDIRADVTRLQE
MAV_1728|M.avium_104 SR-KLPDTERQRLKEILREVVPSDAGVIIRTASEGVKEDDIRGDVTRLQE
MSMEG_4626|M.smegmatis_MC2_155 SR-KLPDTERQRLKEILREVVPSDAGVIIRTASEGVKEEDIRSDVERLQK
TH_0997|M.thermoresistible__bu SR-KLPDTERQRLKEILREVVPPDAGVIIRTASEGVKEEDIRADVNRLQE
Mvan_6043|M.vanbaalenii_PYR-1 DTFRVLAVDVGMHVNVLDWFRPWGT-RATPLINQGAVTFDFRYETG--AG
Mflv_0864|M.gilvum_PYR-GCK DAFHVRAIDLGLHVNLLQLLRPLGSGRATSLVNQGAVTFDFDFTTG--SQ
MAB_3669|M.abscessus_ATCC_1997 ES--FTGKDGLKRWNQIGTIVGKSWDSVIDAIDEIAATPDVDEELS----
. . : : : . . .: . *.
Mb2471c|M.bovis_AF2122/97 RWEQIEAKAQETKEKAAGAAVALYEEPDVLVKVIRDLFNEDFVGLIVSGD
Rv2444c|M.tuberculosis_H37Rv RWEQIEAKAQETKEKAAGAAVALYEEPDVLVKVIRDLFNEDFVGLIVSGD
MLBr_01468|M.leprae_Br4923 HWEQIEAKTIQTKEKAAGAAVALYEEPDVLVKVIRDLFNDDFSGLVVSGD
MMAR_3768|M.marinum_M RWNQIEAKAVEIKQKAAGAAVALYEEPDVLVKVIRDLFNEDFAGLVVSGD
MUL_3715|M.ulcerans_Agy99 RWNQIEAKAVEIKQKAAGAAVALYEEPDVLVKVIRDLFNEDFAGLVVSGD
MAV_1728|M.avium_104 RWKQIEAKAIEIKEKAAGAAVALYEEPDVLVKVIRDLFNEDFAGLIVSGD
MSMEG_4626|M.smegmatis_MC2_155 RWSEIEAKAAEVTEKKAGAAVALYEEPDVLVKVIRDLFNEDFSSLIVSGD
TH_0997|M.thermoresistible__bu RWTQIEAKAAELTEKKAGQAVALYEEPDVLVKVIRDLFNEDFSRLIVSGD
Mvan_6043|M.vanbaalenii_PYR-1 HWS--AERKAALLGAANELVSYLRVNAPVVISYRVDGFDDPTSALLAQAG
Mflv_0864|M.gilvum_PYR-GCK YWT--TPRREALQDAADDLVAYFRVTRPVTLTFEVEGSDNASSSTLASAG
MAB_3669|M.abscessus_ATCC_1997 --------AAADAELLAAAENAVDKDDDLEDDDELDLLDEDSDSDDESSD
. : : :: ...
Mb2471c|M.bovis_AF2122/97 EAWNTINEYVNSVAPELVSKLTKYESADGPDGQSAPDVFTVHRIDEQLAK
Rv2444c|M.tuberculosis_H37Rv EAWNTINEYVNSVAPELVSKLTKYESADGPDGQSAPDVFTVHRIDEQLAK
MLBr_01468|M.leprae_Br4923 EAWNTINEYVNSVAPELVSKLTKYDPPIGPDGQHGPDVFAVHRIDEQLAK
MMAR_3768|M.marinum_M DAWDTINEYVSSVAPDLVSKLSKYEPAVGSEGQVGPDVFAVHRIDEQLAK
MUL_3715|M.ulcerans_Agy99 DAWDTINEYVSSVAPDLVSKLSKYEPAVGSEGQVGPDVFAVHRIDEHLAK
MAV_1728|M.avium_104 DAWNTINEYVNSVAPDLVSKVTKYEPATGPDGTPGPDVFAVHRIDEQLAK
MSMEG_4626|M.smegmatis_MC2_155 EAWNTINSYVEAVAPDLMPRLTKYEPA----GPDAPDVFAVHRIDEQLAK
TH_0997|M.thermoresistible__bu HAWNTINEYVSTVAPDLMPRLTKYEPA----SEDGPDVFAVHRIDEQLAK
Mvan_6043|M.vanbaalenii_PYR-1 SSYTSA----------------------------EPGFWPTLVQNKLISG
Mflv_0864|M.gilvum_PYR-GCK SGTISR----------------------------DPGYWRTVVQNKLLGG
MAB_3669|M.abscessus_ATCC_1997 DAEDESDD-----------------------AAEDDDTEDEDTADDDVVL
. . :. :
Mb2471c|M.bovis_AF2122/97 AMDRKVWLPSGGTLVIDRTEAMTVIDVNTGKFTGAGGNLEQTVTKNNLEA
Rv2444c|M.tuberculosis_H37Rv AMDRKVWLPSGGTLVIDRTEAMTVIDVNTGKFTGAGGNLEQTVTKNNLEA
MLBr_01468|M.leprae_Br4923 AMDRKVWLPSGGTLVIDRTEAMTVIDVNTGKFTGSGGNLEQTVTKNNLEA
MMAR_3768|M.marinum_M AMDRKVWLPSGGTLVIDRTEAMTVVDVNTGKFTGSGGNLEQTVTKNNLEA
MUL_3715|M.ulcerans_Agy99 AMDRKVWLPSGGTLVIDRTEAMTVVDVNTGKFTGSGGNLEQTVTKNNLEA
MAV_1728|M.avium_104 AMDRKVWLPSGGTLVIDRTEAMTVIDVNTGKFTGSGGNLEQTVTKNNLEA
MSMEG_4626|M.smegmatis_MC2_155 AMDRKVWLPSGGTLVIDRTEAMTVVDVNTGKFTGSGGNLEQTVTRNNLEA
TH_0997|M.thermoresistible__bu AMDRKVWLPSGGTLVIDRTEAMTVIDVNTGKFTGSGGNLEQTVTRNNLEA
Mvan_6043|M.vanbaalenii_PYR-1 GDA-------------NGSAADGLIQVN----FGKKWSLDDTVESDEFDF
Mflv_0864|M.gilvum_PYR-GCK EDS-------------NGEEADGSINWN----WGKGWEIGDEVPSDKFDF
MAB_3669|M.abscessus_ATCC_1997 GGDEDFWLEVG--------IDPIQMITNSGTFYTLRCYLNDEP-------
: * : :
Mb2471c|M.bovis_AF2122/97 AEEIVRQLRLRDIGGIVVIDFIDMVLESNRDLVLRRLTESLARDRTRHQV
Rv2444c|M.tuberculosis_H37Rv AEEIVRQLRLRDIGGIVVIDFIDMVLESNRDLVLRRLTESLARDRTRHQV
MLBr_01468|M.leprae_Br4923 AEEIVRQLRLRDIGGIVVIDFIDMVLESNRDLVLRRLTEVLARDRTRHQV
MMAR_3768|M.marinum_M AEEIVRQLRLRDIGGIVVIDFIDMVLESNRDLVLRRLTEALARDRTRHQV
MUL_3715|M.ulcerans_Agy99 AEEIVRQLRLRDIGGIVVIDFIDMVLESNRDLVLRRLTEALARDRTRHQV
MAV_1728|M.avium_104 AEEIVRQLRLRDIGGIVVIDFIDMVLESNRDLVLRRLTEALARDRTRHQV
MSMEG_4626|M.smegmatis_MC2_155 AEEIVRQLRLRDIGGIVVIDFIDMVLESNRDLVLRRLTEALARDRTRHQV
TH_0997|M.thermoresistible__bu AEEIVRQLRLRDIGGIVVIDFIDMVLESNRDLVLRRLTEALARDRTRHQV
Mvan_6043|M.vanbaalenii_PYR-1 MMALMHEM-LHSFG---ILFAVR-PGETTRRYWSTYASLVVDENGSSPFN
Mflv_0864|M.gilvum_PYR-GCK RAVAIHEL-LHAFG---FTSGTEEPGDRDRRHWYILDSFIVTRNGTSPIS
MAB_3669|M.abscessus_ATCC_1997 -------IFLGRNGRISVFGSERALARYLADEHDHDLADLSTYDDIRTAA
: * * . : :
Mb2471c|M.bovis_AF2122/97 SEVTSLGLVQLTRKRLGTGLIEAFSTSCPNCSGRGILLHADPVDSAAATG
Rv2444c|M.tuberculosis_H37Rv SEVTSLGLVQLTRKRLGTGLIEAFSTSCPNCSGRGILLHADPVDSAAATG
MLBr_01468|M.leprae_Br4923 SEVTSLGLVQLTRKRLGTGLVEAFSTSCPNCTGRGILLHTDPANSTPMVG
MMAR_3768|M.marinum_M SEVTSLGLVQLTRKRLGTGLVEAFSTSCPHCSGRGILLHADPVDSAPTTG
MUL_3715|M.ulcerans_Agy99 SEVTSLGLVQLTRKRLGTGLIEAFSTSCPHCSGRGILLHADPVDSAPTTG
MAV_1728|M.avium_104 SEVTSLGLVQLTRKRLGTGLVEAFSTSCPNCGGRGILLHADPVDSAPSNG
MSMEG_4626|M.smegmatis_MC2_155 SEVTSLGLVQLTRKRLGTGLVEAFSTACTHCGGRGIVLHGDPIDSASSNG
TH_0997|M.thermoresistible__bu SEVTSLGLVQLTRKRLGTGLLEAFSTTCTHCNGRGIVLHTDPVDSAQPS-
Mvan_6043|M.vanbaalenii_PYR-1 SDFSWNTAYDPNLTRKDGGLFFGGTEAVEAYDGALIPLFTSDPWLGTSVG
Mflv_0864|M.gilvum_PYR-GCK SDFEWLEEFDGYLEGEDGGLYWGGSHAEDAYGG-YVPIFTPDPWDEGSSG
MAB_3669|M.abscessus_ATCC_1997 TDGSLRIDITDDNIYVFTGLADDLEDGVDEVDRDQLELAVELLTDVAEYS
:: ** : :
Mb2471c|M.bovis_AF2122/97 -RKSEP-------GARRGKRSKKSRSEESSDRSMVAKVPVHAPGEHPMFK
Rv2444c|M.tuberculosis_H37Rv -RKSEP-------GARRGKRSKKSRSEESSDRSMVAKVPVHAPGEHPMFK
MLBr_01468|M.leprae_Br4923 -RKSES-------GGRRSKRSKKNRSDE----TAVVKVPVHAPGEHPMFK
MMAR_3768|M.marinum_M -RKADS-------GGRRNRRSKKNRAEEPSEKEAVAKVPTHAPGEHPMFK
MUL_3715|M.ulcerans_Agy99 -RKADS-------GGRRNRRSKKNRAEEPSEKEAVAKVPTYAPGEHPMFK
MAV_1728|M.avium_104 -RKSES-------GGRRGRR-KKSKAEEP----VVAKVPVHSPGEHPMFK
MSMEG_4626|M.smegmatis_MC2_155 GRKSDSSGGGGSGGGRRGKRGKKGAARTEE--VHVAKVPDHTPGEHPMFK
TH_0997|M.thermoresistible__bu -RRSDS-------GSRRSKRSKR--SRSDD--VQVVKVPPHPPGEHPLFK
Mvan_6043|M.vanbaalenii_PYR-1 ---------------------------------AHLDDMVFIGVDRKMMN
Mflv_0864|M.gilvum_PYR-GCK ---------------------------------AHLDDWTFNDGDEKLMN
MAB_3669|M.abscessus_ATCC_1997 ---------------------------------EDDSVDAELDSDTPLGK
. : : :
Mb2471c|M.bovis_AF2122/97 AMAAGLS---SLAGRGDEE---SGEPAAELA----EQAGDQP--------
Rv2444c|M.tuberculosis_H37Rv AMAAGLS---SLAGRGDEE---SGEPAAELA----EQAGDQP--------
MLBr_01468|M.leprae_Br4923 AMAAGSS---SVVVGGEDE---SNESGTELTGKIDEPLEEQA--------
MMAR_3768|M.marinum_M AMAASSS---SEAEHGDGE---VEESGEELTAAVDDQTAVQV--------
MUL_3715|M.ulcerans_Agy99 AMAASSS---SEAEHGDGE---VEESGEELTAAVDDQTAVQV--------
MAV_1728|M.avium_104 AMAAGSS---TQAASDEDESA-AEEAGDELE-----RKKAAR--------
MSMEG_4626|M.smegmatis_MC2_155 AMAAANG--KHEGDEDHEDHEDHETAEDTTAAEVRDDTRDEH--------
TH_0997|M.thermoresistible__bu AMAAASERADSEAKDDTEETGDGGKDAAKVAAKVKEKVAAEDRAKVGAQD
Mvan_6043|M.vanbaalenii_PYR-1 ASTTPGP---GVRVLSAIELGILKDLGYQVVARTPVEDLA----------
Mflv_0864|M.gilvum_PYR-GCK AATSRGP---SVRTLSDIELGILTDIGYLVYAKAD---------------
MAB_3669|M.abscessus_ATCC_1997 LVGHLLE--PEKHDEPKGPFVDAAERWRTLERAMEARLRRE---------
Mb2471c|M.bovis_AF2122/97 ----------------------------------PTDLD-----------
Rv2444c|M.tuberculosis_H37Rv ----------------------------------PTDLD-----------
MLBr_01468|M.leprae_Br4923 ----------------------------------VAGLD-----------
MMAR_3768|M.marinum_M ----------------------------------ALDLGQTD---ETEET
MUL_3715|M.ulcerans_Agy99 ----------------------------------ALDLG------ETEES
MAV_1728|M.avium_104 ----------------------------------AEELEA----------
MSMEG_4626|M.smegmatis_MC2_155 --------------DADERAHVVTAAVG-----AAGDED-----------
TH_0997|M.thermoresistible__bu GVEEATPDGVETEAAAATRAERVRTAVSGDAQASAGDLDDEDLANGDLED
Mvan_6043|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_0864|M.gilvum_PYR-GCK --------------------------------------------------
MAB_3669|M.abscessus_ATCC_1997 --------------------------------------------------
Mb2471c|M.bovis_AF2122/97 -----DTAQADFED--------TEDTDEDEDE-----------LDADEDL
Rv2444c|M.tuberculosis_H37Rv -----DTAQADFED--------TEDTDEDEDE-----------LDADEDL
MLBr_01468|M.leprae_Br4923 -----DVDQEDFDT--------DEEDDLDDDEE----------LDDEEDL
MMAR_3768|M.marinum_M DETDETDETDDFDD--------DSDDSDDSDEDDDSDETNDTDVDAGEDE
MUL_3715|M.ulcerans_Agy99 EETDGTDETDDFDD--------DSDDSDDSDEDDDTDETNDTDVDADEDE
MAV_1728|M.avium_104 -----AEDTEDLED--------TEDDDEDSDDSDD---------SDDEDL
MSMEG_4626|M.smegmatis_MC2_155 --LDDSDEDSDLDS--------DEESDDESDED---------EIELDDDE
TH_0997|M.thermoresistible__bu EYLDDEDEDEDLEDGDLENGDLDDEDDDEDLEDG--------EIDVDLDE
Mvan_6043|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_0864|M.gilvum_PYR-GCK --------------------------------------------------
MAB_3669|M.abscessus_ATCC_1997 --------------------------------------------------
Mb2471c|M.bovis_AF2122/97 EDLDDE------DLDEDLDVEDS-----------------DSDDEDSDED
Rv2444c|M.tuberculosis_H37Rv EDLDDE------DLDEDLDVEDS-----------------DSDDEDSDED
MLBr_01468|M.leprae_Br4923 GDDDEEL-----DLDDDLDVDE--------------------DESDSEAD
MMAR_3768|M.marinum_M DTDDDSDEDSDDDSDEDEDTEDDELDDDLDEDDLDDDLDEDDDDLDDELD
MUL_3715|M.ulcerans_Agy99 DTDDDS--------DEDEDTEDD---------------DELDDDLDDELD
MAV_1728|M.avium_104 DDEDIDDEEDLGDDDEDLELDD--------------------DDLDTEDS
MSMEG_4626|M.smegmatis_MC2_155 DELDEDIEVIG-DSDDSDDSDDS-------------------DEDDDSDD
TH_0997|M.thermoresistible__bu D-LDDDIEVLNGDPDDEEADEDV-------------------DSYEDPYD
Mvan_6043|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_0864|M.gilvum_PYR-GCK --------------------------------------------------
MAB_3669|M.abscessus_ATCC_1997 --------------------------------------------------
Mb2471c|M.bovis_AF2122/97 AADADVDEED--AAGLDGSPGEVDVPGVTELAPTRPRRRVAGRPAGPPIR
Rv2444c|M.tuberculosis_H37Rv AADADVDEED--AAGLDGSPGEVDVPGVTELAPTRPRRRVAGRPAGPPIR
MLBr_01468|M.leprae_Br4923 LDSADVLDRS--TLLIRNRSG---------FARPR-RRRAAGRPAGPPIH
MMAR_3768|M.marinum_M DDDSDSDDEDGESELTEPAAGRPAALEVTTIAERPRRRRAAGRPAGPPIH
MUL_3715|M.ulcerans_Agy99 DDDSDSDDEDSESELTEPAAGRPAALEVTTIAERPRRRRAAGRPAGPPIH
MAV_1728|M.avium_104 DDSDDSDDSEDSDDSEDQRDPAAECPGVSALGRPR-RRRAAGRPAGPPIH
MSMEG_4626|M.smegmatis_MC2_155 SDDDSDEDEDSDSD-EDEEPVREVYEPPVTAPRARVRRRAAARPAGPPSH
TH_0997|M.thermoresistible__bu ADADADSDSDADADDEDSGDDRAAGRYAAPTVTRRPRRRAAVRPAGPPVQ
Mvan_6043|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_0864|M.gilvum_PYR-GCK --------------------------------------------------
MAB_3669|M.abscessus_ATCC_1997 --------------------------------------------------
Mb2471c|M.bovis_AF2122/97 LD
Rv2444c|M.tuberculosis_H37Rv LD
MLBr_01468|M.leprae_Br4923 VD
MMAR_3768|M.marinum_M LG
MUL_3715|M.ulcerans_Agy99 LG
MAV_1728|M.avium_104 AD
MSMEG_4626|M.smegmatis_MC2_155 D-
TH_0997|M.thermoresistible__bu S-
Mvan_6043|M.vanbaalenii_PYR-1 --
Mflv_0864|M.gilvum_PYR-GCK --
MAB_3669|M.abscessus_ATCC_1997 --