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IDGAPPSDPPEPSQHEELPDRLRVHSLARTLGTTSRRVLDALTALDGRVRSAHSTVDRVDAVRVRDLLAT HLETAGVLAASVHAPEASEEPESRLMLETQETRNADVERPHYMPLFVAPQPIPEPLADDEDVDDGPDYVA DDSDADDEGQLDRPANRRRRRGRRGRGRGRGEQGGSDGDPVDQQSEPRAQQFTSADAAETDDGDDRDSED TEAGDNGEDENGSLEAGNRRRRRRRRRKSASGDDNDAALEGPLPDDPPNTVVHERVPRAGDKAGNSQDGG SGSTEIKGIDGSTRLEAKRQRRRDGRDAGRRRPPVLSEAEFLARREAVERVMVVRDRVRTEPPLPGTRYT QIAVLEDGIVVEHFVTSAASASLVGNIYLGIVQNVLPSMEAAFVDIGRGRNGVLYAGEVNWDAAGLGGAD RKIEQALKPGDYVVVQVSKDPVGHKGARLTTQVSLAGRFLVYVPGASSTGISRKLPDTERQRLKEILREV VPSDAGVIIRTASEGVKEDDIRADVARLRERWEQIEAKAQETKEKAAGAAVALYEEPDVLVKVIRDLFNE DFVGLIVSGDEAWNTINEYVNSVAPELVSKLTKYESADGPDGQSAPDVFTVHRIDEQLAKAMDRKVWLPS GGTLVIDRTEAMTVIDVNTGKFTGAGGNLEQTVTKNNLEAAEEIVRQLRLRDIGGIVVIDFIDMVLESNR DLVLRRLTESLARDRTRHQVSEVTSLGLVQLTRKRLGTGLIEAFSTSCPNCSGRGILLHADPVDSAAATG RKSEPGARRGKRSKKSRSEESSDRSMVAKVPVHAPGEHPMFKAMAAGLSSLAGRGDEESGEPAAELAEQA GDQPPTDLDDTAQADFEDTEDTDEDEDELDADEDLEDLDDEDLDEDLDVEDSDSDDEDSDEDAADADVDE EDAAGLDGSPGEVDVPGVTELAPTRPRRRVAGRPAGPPIRLD*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv2444c | rne | - | 100% (953) | POSSIBLE RIBONUCLEASE E RNE |
| M. tuberculosis H37Rv | Rv2703 | sigA | 6e-08 | 30.60% (183) | RNA polymerase sigma factor |
| M. tuberculosis H37Rv | Rv1297 | rho | 2e-05 | 33.33% (108) | transcription termination factor Rho |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2471c | rne | 0.0 | 100.00% (953) | ribonuclease E |
| M. gilvum PYR-GCK | Mflv_2634 | - | 0.0 | 64.97% (1019) | ribonuclease |
| M. leprae Br4923 | MLBr_01468 | - | 0.0 | 74.33% (966) | putative ribonuclease |
| M. abscessus ATCC 19977 | MAB_1607 | - | 0.0 | 61.86% (991) | ribonuclease E |
| M. marinum M | MMAR_3768 | rne | 0.0 | 71.96% (1027) | ribonuclease E Rne |
| M. avium 104 | MAV_1728 | - | 0.0 | 74.92% (977) | Rne protein |
| M. smegmatis MC2 155 | MSMEG_4626 | - | 0.0 | 63.06% (1053) | ribonuclease, Rne/Rng family protein |
| M. thermoresistible (build 8) | TH_0997 | rne | 0.0 | 68.70% (786) | POSSIBLE RIBONUCLEASE E RNE |
| M. ulcerans Agy99 | MUL_3715 | rne | 0.0 | 73.37% (995) | ribonuclease E Rne |
| M. vanbaalenii PYR-1 | Mvan_3947 | - | 0.0 | 67.75% (958) | ribonuclease |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2634|M.gilvum_PYR-GCK MADNENLQDSNHELGEEPQRLAE---TPSQAKSAPASEKLRVHSLARVLG
Mvan_3947|M.vanbaalenii_PYR-1 MADNENFEAATHDLTDEPQLAAD---SSGSAKDAPAPERLRVHSLARVLG
MSMEG_4626|M.smegmatis_MC2_155 MAEDAHTEDLS---TQTPQQEG-------------LPERLRVHSLARVLG
Rv2444c|M.tuberculosis_H37Rv MIDGAPPSDPP-EPSQHE----------------ELPDRLRVHSLARTLG
Mb2471c|M.bovis_AF2122/97 MIDGAPPSDPP-EPSQHE----------------ELPDRLRVHSLARTLG
MLBr_01468|M.leprae_Br4923 MIDGAPPLEPSKEPTQHM----------------ELPDRLRVHSLARTLG
MMAR_3768|M.marinum_M MVDGAPSSDPENEPTQRE----------------DLPDRLRVHSLARTLG
MUL_3715|M.ulcerans_Agy99 MVDGAPSSDPENEPTQRE----------------DLPDRLRVHSLARTLG
MAV_1728|M.avium_104 MVDGAPTADPSEESTRSG----------------DLPDRLRVHSLARTLG
TH_0997|M.thermoresistible__bu --------------------------------------------------
MAB_1607|M.abscessus_ATCC_1997 MADYELPEDLHTSAPEGEHAALTPDTPPAPAEQGELPEKLRVHSLARVLG
Mflv_2634|M.gilvum_PYR-GCK TTSRRIIDALAELDGRARSAHSTVGPDEADRVREVLAAPEPETTP-----
Mvan_3947|M.vanbaalenii_PYR-1 TTSRRIIDALVELDGRTRSAHSTVGREEADRVREVLAEP-----------
MSMEG_4626|M.smegmatis_MC2_155 TTSRRVLDALAEFDGRQRSAHSTVDKADAERVRAALTESPAAETPPEEAP
Rv2444c|M.tuberculosis_H37Rv TTSRRVLDALTALDGRVRSAHSTVDRVDAVRVRDLLATHL----------
Mb2471c|M.bovis_AF2122/97 TTSRRVLDALTALDGRVRSAHSTVDRVDAVRVRDLLATHL----------
MLBr_01468|M.leprae_Br4923 TTSRRVLDVLSALDGRIRSAHSSVDRVDAVRVRDLLASQP----------
MMAR_3768|M.marinum_M TSSRRVLDALSALDGRIRSAHSSVDRVDAVRVRDLLAEQP----------
MUL_3715|M.ulcerans_Agy99 TSSRRVLDALSALDGRIRSAHSSVDRVDAVRVRDLLAEQP----------
MAV_1728|M.avium_104 TTSKRVLDALSELDGRVRSAHSTVDREDAVRVRDLLAAQP----------
TH_0997|M.thermoresistible__bu --------------------------------------------------
MAB_1607|M.abscessus_ATCC_1997 TSTRRVLDALSNLDGRARSPHSNVDKQDAAKVREVLANEA----------
Mflv_2634|M.gilvum_PYR-GCK -------------EQVTEVATDAVEAQAEPQPEAQ-----AQSEAQAQPQ
Mvan_3947|M.vanbaalenii_PYR-1 -----------------EVAT--------PEPDPE-----ASTPEPAAPE
MSMEG_4626|M.smegmatis_MC2_155 AAETPVADLVVVQAEQVEVVTVSEAGPAEPAEPAEPEAPAAEAEAEAETE
Rv2444c|M.tuberculosis_H37Rv ----------------------------ETAG-----------VLAASVH
Mb2471c|M.bovis_AF2122/97 ----------------------------ETAG-----------VLAASVH
MLBr_01468|M.leprae_Br4923 ----------------------------NSPH-----------ELTAVPD
MMAR_3768|M.marinum_M ----------------------------AEEGQAEEGQQAPDAVAAEVPD
MUL_3715|M.ulcerans_Agy99 ----------------------------AEEGQAEEDQQAPDAVAAEVPD
MAV_1728|M.avium_104 ----------------------------SAELEP--------AAEDAASG
TH_0997|M.thermoresistible__bu --------------------------------------------------
MAB_1607|M.abscessus_ATCC_1997 ---------------------------EAAPVVAETPAPVAAEEAPAVVT
Mflv_2634|M.gilvum_PYR-GCK PGPEAPAPEAPAE------EEPESRLILETPSAPS----TAEPADYLPLF
Mvan_3947|M.vanbaalenii_PYR-1 LQAPDVDAETVTE------DEPESRLILETPVAP-----VSEPADYLPLF
MSMEG_4626|M.smegmatis_MC2_155 VADEAETPEPTFRGAVLVGDEPESRLILEHANIPPARETQTERPDYLPLF
Rv2444c|M.tuberculosis_H37Rv APEA--SEEP------------ESRLMLETQE---TRNADVERPHYMPLF
Mb2471c|M.bovis_AF2122/97 APEA--SEEP------------ESRLMLETQE---TRNADVERPHYMPLF
MLBr_01468|M.leprae_Br4923 NPVA--LEER------------DSRLVLET---------TVERPHYMPLF
MMAR_3768|M.marinum_M APGE--PAEPDEP---------ESRLMLETQETVQVVETWVERPHYMPLF
MUL_3715|M.ulcerans_Agy99 APGE--PAEP------------ESRLMLETQETVQVVETWVERPHYMPLF
MAV_1728|M.avium_104 GPDAGITGEP------------ESRLLLETPD-------ATERPHYMPLF
TH_0997|M.thermoresistible__bu --------------------------------------------------
MAB_1607|M.abscessus_ATCC_1997 GDSADSAEDPDNP--PTTPILIAEATVIEAAAVPVPAAAAPTAYDYGPLF
Mflv_2634|M.gilvum_PYR-GCK VAPQPVRFEDRYEDSDDDDEDASDSDD---SDDSDSDSDDDQSGRPAAKR
Mvan_3947|M.vanbaalenii_PYR-1 VAPQPVRFDEHDHD-DDDGDDVDDDGD---DVDSESDSDEDQPGRPAAKR
MSMEG_4626|M.smegmatis_MC2_155 VAPQPVSFEPAVVDDEDEDDDTETGAESDFDSGADSDSDDDQADRP--RR
Rv2444c|M.tuberculosis_H37Rv VAPQPIPEPLADDEDVDDGPDYVADDS--------DADDEGQLDRPANRR
Mb2471c|M.bovis_AF2122/97 VAPQPIPEPLADDEDVDDGPDYVADDS--------DADDEGQLDRPANRR
MLBr_01468|M.leprae_Br4923 VAPQPI--EVDDDSCADDDVESGDDSD--------VGDDEEQPDRPANRR
MMAR_3768|M.marinum_M VAPQPISEPVAGDDADDESGDEGDD-------------DEEQADRPANRR
MUL_3715|M.ulcerans_Agy99 VAPQPISEPVAGDDADDESGDEGDD-------------DEEQADRPGNRR
MAV_1728|M.avium_104 VAPQPLE-SSDDDGDADETADSDDSD----------GDDDEQADRPSSRR
TH_0997|M.thermoresistible__bu --------------------------------------------------
MAB_1607|M.abscessus_ATCC_1997 VAPQAPEPQERPAPVRTEKAEDVDEDAG---ETDDSDADGEGDGDRPARR
Mflv_2634|M.gilvum_PYR-GCK RRRGRRGRGRGRGEQNGDEPSDADGDS--------DGDAETEKARSDDSE
Mvan_3947|M.vanbaalenii_PYR-1 RRRGRRGRGRGRGEQNGDESS-ADSD---------EGDVDTEKAQSGESA
MSMEG_4626|M.smegmatis_MC2_155 RRRGRRGRGRGRGEQNDDATSDADTDS--------TEDQTDGDEQ--ESG
Rv2444c|M.tuberculosis_H37Rv RRRGRRGRGRGRGEQGGSDGDPVDQQSEPRAQQFTSADAAETDDGDDRDS
Mb2471c|M.bovis_AF2122/97 RRRGRRGRGRGRGEQGGSDGDPVDQQSEPRAQQFTSADAAETDDGDDRDS
MLBr_01468|M.leprae_Br4923 RRRGRRGRGRGRGEQGGSDVQSDDVDG--------AVDSTESEDFDGQDF
MMAR_3768|M.marinum_M RRRGRRGRGRGRGEQGANDGQDQPGDDGDEAPQKTGGNSTSSDDTEAQDG
MUL_3715|M.ulcerans_Agy99 RRRGRRGRGRGRGEQGANDGQDQPGDDGDEAPQKAGGNSTSSDDSEAQDG
MAV_1728|M.avium_104 RRRGRRGRGRGRGEQGGSDGPGDGDNDEPQNRGKKGGQSDGDDDSDGQDA
TH_0997|M.thermoresistible__bu --------------------------------------------------
MAB_1607|M.abscessus_ATCC_1997 RRRGRRGRGRGRGEQGGGEGSDDSGDD-AAAEGGEAAEGDDAADGTGDDS
Mflv_2634|M.gilvum_PYR-GCK DDNGEDDNGDDDGAGGDAGTRRRRRRRRRKSGSDDDN---GSGGSPDDPP
Mvan_3947|M.vanbaalenii_PYR-1 DDS-DDDSGEDDGTGADGATRRRRRRRRRKSGSDDD----GENGSPDDPP
MSMEG_4626|M.smegmatis_MC2_155 EDS--DDSGDEDSTTTEGGTRRRRRRRRRKSGSGDS----DDAVSPDDPP
Rv2444c|M.tuberculosis_H37Rv EDTEAGDNGEDENGSLEAGNRRRRRRRRRKSASGDDNDAALEGPLPDDPP
Mb2471c|M.bovis_AF2122/97 EDTEAGDNGEDENGSLEAGNRRRRRRRRRKSASGDDNDAALEGPLPDDPP
MLBr_01468|M.leprae_Br4923 DESEDTEIGYDESGSSEAGNRRRRRRRRRKSGVGED-----EGCAPDDPP
MMAR_3768|M.marinum_M ADSEESDNGDDDNGSADGANRRRRRRRRRKSGAGDDGD---EGPAPDDPP
MUL_3715|M.ulcerans_Agy99 ADSEESDNGDDDNGSADGASRRRRRRRRRKSGAGDDGD---EGPAPDDPP
MAV_1728|M.avium_104 EDADDSDTGDD--GSADGGNRRRRRRRRRKSGSGDDNE---DGPSPDDPP
TH_0997|M.thermoresistible__bu -------------------------------------------VSPDDPP
MAB_1607|M.abscessus_ATCC_1997 PAPDGDESNAEDGDTPEGASRRRRRRRRRKAGSGDDG----DGPSDDDPP
****
Mflv_2634|M.gilvum_PYR-GCK NTVVHEREPRKSG-RADKGDK-----SDEIQGISGSTRLEAKRQRRRDGR
Mvan_3947|M.vanbaalenii_PYR-1 NTVVHEREPRKSANRGDKTSS-----DSEIQGISGSTRLEAKRQRRRDGR
MSMEG_4626|M.smegmatis_MC2_155 NTVVHERAPRTER--SDKSD------DSEIQGISGSTRLEAKRQRRRDGR
Rv2444c|M.tuberculosis_H37Rv NTVVHERVPRAGDKAGNSQD--GGSGSTEIKGIDGSTRLEAKRQRRRDGR
Mb2471c|M.bovis_AF2122/97 NTVVHERVPRAGDKAGNSQD--GGSGSTEIKGIDGSTRLEAKRQRRRDGR
MLBr_01468|M.leprae_Br4923 NTVVHERTPRAAGRSASFDNGVNGTGSADIKGIDGSTRLEAKRQRRRDGR
MMAR_3768|M.marinum_M NTVVHERAPRSGGKSGNSDSG-DDSGGNEIKGIDGSTRLEAKRQRRRDGR
MUL_3715|M.ulcerans_Agy99 NTVVHERAPRSGDKSGNSDSG-DDSGGNEIKGIDGSTRLEAKRQRRRDGR
MAV_1728|M.avium_104 NTVVHERPPRNGKNGG--DDG-NGSSSSEIKGIDGSTRLEAKRQRRRDGR
TH_0997|M.thermoresistible__bu NTVVHERVPRTEKEER-------DQAHSEIQGITGSTRLEAKRQRRRDGR
MAB_1607|M.abscessus_ATCC_1997 NTVVHERKPRAER-------------GDEIQGISGSTRLEAKRQRRRDGR
******* ** :*:** ****************
Mflv_2634|M.gilvum_PYR-GCK DAGRRRPPILSEAEFLARREAVERTMVVRDKVRTEPPHEGARYTQIAVLE
Mvan_3947|M.vanbaalenii_PYR-1 DAGRRRPPILSEAEFLARREAVERMMVIRDKVRTEPPHEGARYTQIAVLE
MSMEG_4626|M.smegmatis_MC2_155 DAGRRRPPILSEAEFLARREAVERTMIVRDKVRTEPPHEGARYTQIAVLE
Rv2444c|M.tuberculosis_H37Rv DAGRRRPPVLSEAEFLARREAVERVMVVRDRVRTEPPLPGTRYTQIAVLE
Mb2471c|M.bovis_AF2122/97 DAGRRRPPVLSEAEFLARREAVERVMVVRDRVRTEPPLPGTRYTQIAVLE
MLBr_01468|M.leprae_Br4923 DAGRRRSSVLSEAEFLARRESVERVMVVRDRIRTEPPHPGARYTQIAVLE
MMAR_3768|M.marinum_M DAGRRRPPVLSEAEFLARREAVERVMVVRDRVRTEPPHPGSRYTQIAVLE
MUL_3715|M.ulcerans_Agy99 DAGRRRPPVLSEAEFLARREAVERVMVVRDRVRTEPPHPGSRYTQIAVLE
MAV_1728|M.avium_104 DAGRRRPPVLTEAEFLARREAVERVMVVRDRIRTEPPHQGSRYTQIAVLE
TH_0997|M.thermoresistible__bu DAGRRRPPILSEAEFLARREAVERVMVVRDKVRTEPPHQGARYTQIAVLE
MAB_1607|M.abscessus_ATCC_1997 DAGRRRPPILTEAEFLARREAVDRVMVVRDKTRSEPPHEGARYTQIAVLE
******..:*:*********:*:* *::**: *:*** *:*********
Mflv_2634|M.gilvum_PYR-GCK DGVVVEHFVTSAAQVSLVGNIYLGIVQNVLPSMEAAFVDIGRGRNGVLYA
Mvan_3947|M.vanbaalenii_PYR-1 DGVVVEHFVTSAASASLVGNIYLGIVQNVLPSMEAAFVDIGRGRNGVLYA
MSMEG_4626|M.smegmatis_MC2_155 DGVVVEHFVTSAASASLVGNIYLGIVQNVLPSMEAAFVDIGRGRNGVLYA
Rv2444c|M.tuberculosis_H37Rv DGIVVEHFVTSAASASLVGNIYLGIVQNVLPSMEAAFVDIGRGRNGVLYA
Mb2471c|M.bovis_AF2122/97 DGIVVEHFVTSAASASLVGNIYLGIVQNVLPSMEAAFVDIGRGRNGVLYA
MLBr_01468|M.leprae_Br4923 DGIVVEHFVTSAASASLVGNIYLGIVQNVLPSMEAAFVDIGRGRNGVLYA
MMAR_3768|M.marinum_M DGIVVEHFVTSAASASLVGNIYLGIVQNVLPSMEAAFVDIGRGRNGVLYA
MUL_3715|M.ulcerans_Agy99 DGIVVEHFVTSAASASLVGNIYLGIVQNVLPSMEAAFVDIGRGRNGVLYA
MAV_1728|M.avium_104 DGIVVEHFVTSAASASLVGNIYLGIVQNVLPSMEAAFVDIGRGRNGVLYA
TH_0997|M.thermoresistible__bu DGVVVEHFVTSSASASLVGNIYLGIVQNVLPSMEAAFVDIGRGRNGVLYA
MAB_1607|M.abscessus_ATCC_1997 DGVLVEHFVTSAASASLVGNIYLGVVQNVLPSMEAAFVDIGRGRNGVLYA
**::*******:*..*********:*************************
Mflv_2634|M.gilvum_PYR-GCK GEVNWEAAGLGGAQRKIEQALKPGDYVVVQVSKDPVGHKGARLTTQVSLA
Mvan_3947|M.vanbaalenii_PYR-1 GEVNWEAAGLGGAQRKIEQALKPGDYVVVQVSKDPVGHKGARLTTQVSLA
MSMEG_4626|M.smegmatis_MC2_155 GEVNWEAAGLGGQNRKIEQALKPGDYVVVQVSKDPVGHKGARLTTQVSLA
Rv2444c|M.tuberculosis_H37Rv GEVNWDAAGLGGADRKIEQALKPGDYVVVQVSKDPVGHKGARLTTQVSLA
Mb2471c|M.bovis_AF2122/97 GEVNWDAAGLGGADRKIEQALKPGDYVVVQVSKDPVGHKGARLTTQVSLA
MLBr_01468|M.leprae_Br4923 GEVNWEAAGLGGADRKIEQALKPGDYIVVQVNKDPVGHKGARLTTQVSLA
MMAR_3768|M.marinum_M GEVNWDAAGLGGADRKIEQALKPGDYIVVQVSKDPVGHKGARLTTQVSLA
MUL_3715|M.ulcerans_Agy99 GEVNWDAAGLGGADRKIEQALKPGDYIVVQVSKDPVGHKGARLTTQVSLA
MAV_1728|M.avium_104 GEVNWEAAGLGGSDRKIEQALKPGDYVVVQVSKDPVGHKGARLTTQVSLA
TH_0997|M.thermoresistible__bu GEVNWEAAGLGGQNRKIEQALKPGDYVVVQVSKDPVGHKGARLTTQLSLA
MAB_1607|M.abscessus_ATCC_1997 GEVNWDAAGLGGSNRKIEQALKSGDYVLVQVSKDPVGHKGARLTTQISLA
*****:****** :********.***::***.**************:***
Mflv_2634|M.gilvum_PYR-GCK GRYLVYVPGASSTGISRKLPDTERQRLKEILREVVPSNAGVIIRTASEGV
Mvan_3947|M.vanbaalenii_PYR-1 GRYLVYVPGASSTGISRKLPDTERQRLKEILREVVPSDAGVIIRTASEGV
MSMEG_4626|M.smegmatis_MC2_155 GRYLVYVPGASSTGISRKLPDTERQRLKEILREVVPSDAGVIIRTASEGV
Rv2444c|M.tuberculosis_H37Rv GRFLVYVPGASSTGISRKLPDTERQRLKEILREVVPSDAGVIIRTASEGV
Mb2471c|M.bovis_AF2122/97 GRFLVYVPGASSTGISRKLPDTERQRLKEILREVVPSDAGVIIRTASEGV
MLBr_01468|M.leprae_Br4923 GRYLVYVPGASSTGISRKLPDTERQRLKEILREVVPPDAGVIIRTASEGV
MMAR_3768|M.marinum_M GRYLVYVPGASSTGISRKLPDTERQRLKEILREVVPSDAGVIIRTASEGV
MUL_3715|M.ulcerans_Agy99 GRYLVYVAGASSTGISRKLPDTERQRLKEILREVVPSDAGVIIRTASEGV
MAV_1728|M.avium_104 GRYLVYVPGASSTGISRKLPDTERQRLKEILREVVPSDAGVIIRTASEGV
TH_0997|M.thermoresistible__bu GRYLVYVPGATSTGISRKLPDTERQRLKEILREVVPPDAGVIIRTASEGV
MAB_1607|M.abscessus_ATCC_1997 GRYLVYVPGASSTGISRKLPDTERQRLKEILRDIVPADAGVIIRTASEGV
**:****.**:*********************::**.:************
Mflv_2634|M.gilvum_PYR-GCK KEDDIRTDVERLQKRWTDIEAKAAEVTAKKAGAAVALYEEPDVLVKVIRD
Mvan_3947|M.vanbaalenii_PYR-1 KEEDIRSDVERLQKRWTEIEAKAAEITEKKAGAAVALYEEPDVLVKVIRD
MSMEG_4626|M.smegmatis_MC2_155 KEEDIRSDVERLQKRWSEIEAKAAEVTEKKAGAAVALYEEPDVLVKVIRD
Rv2444c|M.tuberculosis_H37Rv KEDDIRADVARLRERWEQIEAKAQETKEKAAGAAVALYEEPDVLVKVIRD
Mb2471c|M.bovis_AF2122/97 KEDDIRADVARLRERWEQIEAKAQETKEKAAGAAVALYEEPDVLVKVIRD
MLBr_01468|M.leprae_Br4923 KEEDIRKDVTRLQEHWEQIEAKTIQTKEKAAGAAVALYEEPDVLVKVIRD
MMAR_3768|M.marinum_M KEDDIRADVTRLQERWNQIEAKAVEIKQKAAGAAVALYEEPDVLVKVIRD
MUL_3715|M.ulcerans_Agy99 KEDDIRADVTRLQERWNQIEAKAVEIKQKAAGAAVALYEEPDVLVKVIRD
MAV_1728|M.avium_104 KEDDIRGDVTRLQERWKQIEAKAIEIKEKAAGAAVALYEEPDVLVKVIRD
TH_0997|M.thermoresistible__bu KEEDIRADVNRLQERWTQIEAKAAELTEKKAGQAVALYEEPDVLVKVIRD
MAB_1607|M.abscessus_ATCC_1997 REEDIRADVQRLQEQWQGIEQSATDLTSKASGAAVALYEEPDVLVKVVRD
:*:*** ** **:::* ** .: : . * :* **************:**
Mflv_2634|M.gilvum_PYR-GCK LFNEDFSNLIVSGDQAWKTIDDYVTAVAPELLPRITRYEPAGSPEAGTAP
Mvan_3947|M.vanbaalenii_PYR-1 LFNEDFTGLTVSGDHAWKTINDYVTAVAPELLPRMTQYEPASP----DAP
MSMEG_4626|M.smegmatis_MC2_155 LFNEDFSSLIVSGDEAWNTINSYVEAVAPDLMPRLTKYEPAGP----DAP
Rv2444c|M.tuberculosis_H37Rv LFNEDFVGLIVSGDEAWNTINEYVNSVAPELVSKLTKYESADGPDGQSAP
Mb2471c|M.bovis_AF2122/97 LFNEDFVGLIVSGDEAWNTINEYVNSVAPELVSKLTKYESADGPDGQSAP
MLBr_01468|M.leprae_Br4923 LFNDDFSGLVVSGDEAWNTINEYVNSVAPELVSKLTKYDPPIGPDGQHGP
MMAR_3768|M.marinum_M LFNEDFAGLVVSGDDAWDTINEYVSSVAPDLVSKLSKYEPAVGSEGQVGP
MUL_3715|M.ulcerans_Agy99 LFNEDFAGLVVSGDDAWDTINEYVSSVAPDLVSKLSKYEPAVGSEGQVGP
MAV_1728|M.avium_104 LFNEDFAGLIVSGDDAWNTINEYVNSVAPDLVSKVTKYEPATGPDGTPGP
TH_0997|M.thermoresistible__bu LFNEDFSRLIVSGDHAWNTINEYVSTVAPDLMPRLTKYEPAS----EDGP
MAB_1607|M.abscessus_ATCC_1997 LFNEDFSKLIIEGDAAWDTIDDYVKTVAPDLLSRIERYESGE------GP
***:** * :.** **.**:.** :***:*:.:: :*:. .*
Mflv_2634|M.gilvum_PYR-GCK DVFAVHRIDEQLAKAMDRKVYLPSGGTLVIDRTEAMTVVDVNTGKFTGSG
Mvan_3947|M.vanbaalenii_PYR-1 DVFAVHRIDEQLAKAMDRKVWLPSGGTLVIDRTEAMTVVDVNTGKFTGSG
MSMEG_4626|M.smegmatis_MC2_155 DVFAVHRIDEQLAKAMDRKVWLPSGGTLVIDRTEAMTVVDVNTGKFTGSG
Rv2444c|M.tuberculosis_H37Rv DVFTVHRIDEQLAKAMDRKVWLPSGGTLVIDRTEAMTVIDVNTGKFTGAG
Mb2471c|M.bovis_AF2122/97 DVFTVHRIDEQLAKAMDRKVWLPSGGTLVIDRTEAMTVIDVNTGKFTGAG
MLBr_01468|M.leprae_Br4923 DVFAVHRIDEQLAKAMDRKVWLPSGGTLVIDRTEAMTVIDVNTGKFTGSG
MMAR_3768|M.marinum_M DVFAVHRIDEQLAKAMDRKVWLPSGGTLVIDRTEAMTVVDVNTGKFTGSG
MUL_3715|M.ulcerans_Agy99 DVFAVHRIDEHLAKAMDRKVWLPSGGTLVIDRTEAMTVVDVNTGKFTGSG
MAV_1728|M.avium_104 DVFAVHRIDEQLAKAMDRKVWLPSGGTLVIDRTEAMTVIDVNTGKFTGSG
TH_0997|M.thermoresistible__bu DVFAVHRIDEQLAKAMDRKVWLPSGGTLVIDRTEAMTVIDVNTGKFTGSG
MAB_1607|M.abscessus_ATCC_1997 DVFAVHRIDEQLAKALDRKVWLPSGGTLVIDRTEAMTVVDVNTGKFTGAG
***:******:****:****:*****************:*********:*
Mflv_2634|M.gilvum_PYR-GCK GNLEQTVTRNNLEAAEETVRQLRLRDIGGIVVIDFIDMVLESNRDLVLRR
Mvan_3947|M.vanbaalenii_PYR-1 GNLEQTVTRNNLEAAEEIVRQLRLRDIGGIVVIDFIDMVLESNRDLVLRR
MSMEG_4626|M.smegmatis_MC2_155 GNLEQTVTRNNLEAAEEIVRQLRLRDIGGIVVIDFIDMVLESNRDLVLRR
Rv2444c|M.tuberculosis_H37Rv GNLEQTVTKNNLEAAEEIVRQLRLRDIGGIVVIDFIDMVLESNRDLVLRR
Mb2471c|M.bovis_AF2122/97 GNLEQTVTKNNLEAAEEIVRQLRLRDIGGIVVIDFIDMVLESNRDLVLRR
MLBr_01468|M.leprae_Br4923 GNLEQTVTKNNLEAAEEIVRQLRLRDIGGIVVIDFIDMVLESNRDLVLRR
MMAR_3768|M.marinum_M GNLEQTVTKNNLEAAEEIVRQLRLRDIGGIVVIDFIDMVLESNRDLVLRR
MUL_3715|M.ulcerans_Agy99 GNLEQTVTKNNLEAAEEIVRQLRLRDIGGIVVIDFIDMVLESNRDLVLRR
MAV_1728|M.avium_104 GNLEQTVTKNNLEAAEEIVRQLRLRDIGGIVVIDFIDMVLESNRDLVLRR
TH_0997|M.thermoresistible__bu GNLEQTVTRNNLEAAEEIVRQLRLRDIGGIVVIDFIDMVLESNRDLVLRR
MAB_1607|M.abscessus_ATCC_1997 GNLEETVTRNNLEAAEEIVRQLRLRDVGGIVVIDFIDMVLESNRDLVLRR
****:***:******** ********:***********************
Mflv_2634|M.gilvum_PYR-GCK LTEALARDRTRHQVSEVTSLGLVQLTRKRLGTGLIEAFSTTCTHCSGRGI
Mvan_3947|M.vanbaalenii_PYR-1 LTEALARDRTRHQVSEVTSLGLVQLTRKKLGTGLIEAFSTTCSHCAGRGI
MSMEG_4626|M.smegmatis_MC2_155 LTEALARDRTRHQVSEVTSLGLVQLTRKRLGTGLVEAFSTACTHCGGRGI
Rv2444c|M.tuberculosis_H37Rv LTESLARDRTRHQVSEVTSLGLVQLTRKRLGTGLIEAFSTSCPNCSGRGI
Mb2471c|M.bovis_AF2122/97 LTESLARDRTRHQVSEVTSLGLVQLTRKRLGTGLIEAFSTSCPNCSGRGI
MLBr_01468|M.leprae_Br4923 LTEVLARDRTRHQVSEVTSLGLVQLTRKRLGTGLVEAFSTSCPNCTGRGI
MMAR_3768|M.marinum_M LTEALARDRTRHQVSEVTSLGLVQLTRKRLGTGLVEAFSTSCPHCSGRGI
MUL_3715|M.ulcerans_Agy99 LTEALARDRTRHQVSEVTSLGLVQLTRKRLGTGLIEAFSTSCPHCSGRGI
MAV_1728|M.avium_104 LTEALARDRTRHQVSEVTSLGLVQLTRKRLGTGLVEAFSTSCPNCGGRGI
TH_0997|M.thermoresistible__bu LTEALARDRTRHQVSEVTSLGLVQLTRKRLGTGLLEAFSTTCTHCNGRGI
MAB_1607|M.abscessus_ATCC_1997 LTEALGRDRTRHQVSEVTSLGLVQLTRKKLGTGLIEAFSSTCTHCAGRGI
*** *.**********************:*****:****::*.:* ****
Mflv_2634|M.gilvum_PYR-GCK MLHGDPVDSS--SGSNGRKADSGGGGNGGGGGGGGRRSRRGKRGAKPEP-
Mvan_3947|M.vanbaalenii_PYR-1 MLHGDPVDSM--APANGRKSEPG----------TGRRSKRGKRGARAEQ-
MSMEG_4626|M.smegmatis_MC2_155 VLHGDPIDSA--SSNGGRKSDSSG----GGGSGGGRRGKRGKKGAARTE-
Rv2444c|M.tuberculosis_H37Rv LLHADPVDS---AAATGRKSEPG-----------ARRGKRSKKSRSEESS
Mb2471c|M.bovis_AF2122/97 LLHADPVDS---AAATGRKSEPG-----------ARRGKRSKKSRSEESS
MLBr_01468|M.leprae_Br4923 LLHTDPANS---TPMVGRKSESG-----------GRRSKRSKKNRSDE--
MMAR_3768|M.marinum_M LLHADPVDS---APTTGRKADSG-----------GRRNRRSKKNRAEEPS
MUL_3715|M.ulcerans_Agy99 LLHADPVDS---APTTGRKADSG-----------GRRNRRSKKNRAEEPS
MAV_1728|M.avium_104 LLHADPVDS---APSNGRKSESG-----------GRRGRR-KKSKAEEP-
TH_0997|M.thermoresistible__bu VLHTDPVDS---AQPS-RRSDSG-----------SRRSKRSKRSRSDD--
MAB_1607|M.abscessus_ATCC_1997 VLHVDPVDNASNASSPAKKAETG------------RRAKRSRKGKTDD--
:** ** :. : ::::.. ** :* ::.
Mflv_2634|M.gilvum_PYR-GCK -EVQVTKVPAHLPGEHPMFKAMAAANGKDE------DGEDGQDGEERDDV
Mvan_3947|M.vanbaalenii_PYR-1 -EVPVVKVPSHSPGEHPMFKAMAAANGKHE------DDDS---EHEDDGT
MSMEG_4626|M.smegmatis_MC2_155 -EVHVAKVPDHTPGEHPMFKAMAAANGKHEGDEDHEDHEDHETAEDTTAA
Rv2444c|M.tuberculosis_H37Rv DRSMVAKVPVHAPGEHPMFKAMAAGLS-----SLAGRGDEE---SGEPAA
Mb2471c|M.bovis_AF2122/97 DRSMVAKVPVHAPGEHPMFKAMAAGLS-----SLAGRGDEE---SGEPAA
MLBr_01468|M.leprae_Br4923 --TAVVKVPVHAPGEHPMFKAMAAGSS-----SVVVGGEDE---SNESGT
MMAR_3768|M.marinum_M EKEAVAKVPTHAPGEHPMFKAMAASSS-----SEAEHGDGE---VEESGE
MUL_3715|M.ulcerans_Agy99 EKEAVAKVPTYAPGEHPMFKAMAASSS-----SEAEHGDGE---VEESGE
MAV_1728|M.avium_104 ---VVAKVPVHSPGEHPMFKAMAAGSS-----TQAASDEDESA-AEEAGD
TH_0997|M.thermoresistible__bu --VQVVKVPPHPPGEHPLFKAMAAASERAD--SEAKDDTEETGDGGKDAA
MAB_1607|M.abscessus_ATCC_1997 --VVVARTPSHPQGEHPMFKAMAAANG-------HHEDDED---ADVNED
*.:.* : ****:******.
Mflv_2634|M.gilvum_PYR-GCK SLAPEEVAEIDADATPTVADTDD---------------------------
Mvan_3947|M.vanbaalenii_PYR-1 AVPPEEVAELDADATRAVTDSD----------------------------
MSMEG_4626|M.smegmatis_MC2_155 EVRDDTRDEHDADERAHVVTAAVG--------------------------
Rv2444c|M.tuberculosis_H37Rv ELA----EQAGDQPPTDLD-------------------------------
Mb2471c|M.bovis_AF2122/97 ELA----EQAGDQPPTDLD-------------------------------
MLBr_01468|M.leprae_Br4923 ELTGKIDEPLEEQAVAGLD-------------------------------
MMAR_3768|M.marinum_M ELTAAVDDQTAVQVALDLGQTD----------------------------
MUL_3715|M.ulcerans_Agy99 ELTAAVDDQTAVQVALDLG-------------------------------
MAV_1728|M.avium_104 ELERKKAARAEELEAAEDT-------------------------------
TH_0997|M.thermoresistible__bu KVAAKVKEKVAAEDRAKVGAQDGVEEATPDGVETEAAAATRAERVRTAVS
MAB_1607|M.abscessus_ATCC_1997 ALDDDALEEVEEVEEIVET-------------------------------
:
Mflv_2634|M.gilvum_PYR-GCK -------------EFGDDSEDDDSEDDDSEDDDSEDDDSDVDEIDLDDDD
Mvan_3947|M.vanbaalenii_PYR-1 ----------------DDDLDDDFDDEDADDEDTDDED----EIDLDDDD
MSMEG_4626|M.smegmatis_MC2_155 -------------AAGDEDLDDSDEDSDLDSDEESDDESDEDEIELDDDE
Rv2444c|M.tuberculosis_H37Rv -------------DTAQADFEDTEDTDEDEDE-----------LDADEDL
Mb2471c|M.bovis_AF2122/97 -------------DTAQADFEDTEDTDEDEDE-----------LDADEDL
MLBr_01468|M.leprae_Br4923 -------------DVDQEDFDTDEEDDLDDDEE----------LDDEEDL
MMAR_3768|M.marinum_M ---ETEETDETDETDETDDFDDDSDDSDDSDEDDDSDETNDTDVDAGEDE
MUL_3715|M.ulcerans_Agy99 ---ETEESEETDGTDETDDFDDDSDDSDDSDEDDDTDETNDTDVDADEDE
MAV_1728|M.avium_104 --------------EDLEDTEDDDEDSDDSDD------------SDDEDL
TH_0997|M.thermoresistible__bu GDAQASAGDLDDEDLANGDLEDEYLDDEDEDEDLEDGDLENGDLDDEDDD
MAB_1607|M.abscessus_ATCC_1997 --------------IQSAETPDNVPDQD----------------EPEHEP
. . . .:
Mflv_2634|M.gilvum_PYR-GCK EDEDDD----IDELDDDEDSDDED--------------------EDDDED
Mvan_3947|M.vanbaalenii_PYR-1 DEADDD----IEELDD-EDSDDEE--------------------TDEDSD
MSMEG_4626|M.smegmatis_MC2_155 DELDED----IEVIGDSDDSDDSDD-----------------SDEDDDSD
Rv2444c|M.tuberculosis_H37Rv EDLDDE------DLDEDLDVEDS-----------------DSDDEDSDED
Mb2471c|M.bovis_AF2122/97 EDLDDE------DLDEDLDVEDS-----------------DSDDEDSDED
MLBr_01468|M.leprae_Br4923 GDDDEEL-----DLDDDLDVDE--------------------DESDSEAD
MMAR_3768|M.marinum_M DTDDDSDEDSDDDSDEDEDTEDDELDDDLDEDDLDDDLDEDDDDLDDELD
MUL_3715|M.ulcerans_Agy99 DTDDDS--------DEDEDTEDD---------------DELDDDLDDELD
MAV_1728|M.avium_104 DDEDIDDEEDLGDDDEDLELDD--------------------DDLDTEDS
TH_0997|M.thermoresistible__bu EDLEDGE----IDVDLDEDLDDDIEVLN-----------GDPDDEEADED
MAB_1607|M.abscessus_ATCC_1997 ASAGSN--------AASEPWAEG--------------------APEAAAT
: :
Mflv_2634|M.gilvum_PYR-GCK DD---------SDFDDDDEDEDSDEDDEEE-----PVAAAPVGRHRRRAA
Mvan_3947|M.vanbaalenii_PYR-1 D--------------EDTDGEDSDEEEEPV-----AVAVRP-GRQRRRAA
MSMEG_4626|M.smegmatis_MC2_155 DS---------DDDSDEDEDSDSDEDEEPVREVYEPPVTAPRARVRRRAA
Rv2444c|M.tuberculosis_H37Rv AA--------DADVD-EED--AAGLDGSPGEVDVPGVTELAPTRPRRRVA
Mb2471c|M.bovis_AF2122/97 AA--------DADVD-EED--AAGLDGSPGEVDVPGVTELAPTRPRRRVA
MLBr_01468|M.leprae_Br4923 LD--------SADVL-DRS--TLLIRNRSG---------FARPR-RRRAA
MMAR_3768|M.marinum_M DD--------DSDSD-DEDGESELTEPAAGRPAALEVTTIAERPRRRRAA
MUL_3715|M.ulcerans_Agy99 DD--------DSDSD-DEDSESELTEPAAGRPAALEVTTIAERPRRRRAA
MAV_1728|M.avium_104 DD--------SDDSD-DSEDSDDSEDQRDPAAECPGVSALGRPR-RRRAA
TH_0997|M.thermoresistible__bu VDSYEDPYDADADADSDSDADADDEDSGDDRAAGRYAAPTVTRRPRRRAA
MAB_1607|M.abscessus_ATCC_1997 EP--------------------GTAEPEAPAATPEPAAAAPTRPRRRRSA
*** *
Mflv_2634|M.gilvum_PYR-GCK ARPAGPPIRD-
Mvan_3947|M.vanbaalenii_PYR-1 ARPAGPPSQD-
MSMEG_4626|M.smegmatis_MC2_155 ARPAGPPSHD-
Rv2444c|M.tuberculosis_H37Rv GRPAGPPIRLD
Mb2471c|M.bovis_AF2122/97 GRPAGPPIRLD
MLBr_01468|M.leprae_Br4923 GRPAGPPIHVD
MMAR_3768|M.marinum_M GRPAGPPIHLG
MUL_3715|M.ulcerans_Agy99 GRPAGPPIHLG
MAV_1728|M.avium_104 GRPAGPPIHAD
TH_0997|M.thermoresistible__bu VRPAGPPVQS-
MAB_1607|M.abscessus_ATCC_1997 ARAAGPPVEH-
*.**** .