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VSTHTHRRARRSEAFAVRRWLHAGAVTAGMGAALLGFGVLAETATAAADPGSESASAGATNAGPSAGEDG GSTAPDAATDADAATDADETDDAAADADETADDDEAADDAAAEEPDAEPVAVKPSTHRTKADTAVEAAVA EQVSSTALPGRAATQPPYVSEQSAYEKRVAESLAAWTQRNQEWVDSLDVTDERKERMQESFVAMRTTFFN QAPTIAPVQITGVITGPVTGTIGAIDPDGDRLRYVITRAPATGTVKINVDGTYTYTPGAEFDGVDAFHVR AIDLGLHVNLLQLLRPLGSGRATSLVNQGAVTFDFDFTTGSQYWTTPRREALQDAADDLVAYFRVTRPVT LTFEVEGSDNASSSTLASAGSGTISRDPGYWRTVVQNKLLGGEDSNGEEADGSINWNWGKGWEIGDEVPS DKFDFRAVAIHELLHAFGFTSGTEEPGDRDRRHWYILDSFIVTRNGTSPISSDFEWLEEFDGYLEGEDGG LYWGGSHAEDAYGGYVPIFTPDPWDEGSSGAHLDDWTFNDGDEKLMNAATSRGPSVRTLSDIELGILTDI GYLVYAKAD
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_0864 | - | - | 100% (569) | hypothetical protein Mflv_0864 |
| M. gilvum PYR-GCK | Mflv_0863 | - | e-125 | 45.60% (579) | hypothetical protein Mflv_0863 |
| M. gilvum PYR-GCK | Mflv_0862 | - | e-125 | 44.29% (578) | hypothetical protein Mflv_0862 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3469c | - | 2e-05 | 32.09% (134) | hypothetical protein Mb3469c |
| M. tuberculosis H37Rv | Rv3439c | - | 2e-05 | 32.09% (134) | hypothetical protein Rv3439c |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | - | - | - | - | - |
| M. marinum M | MMAR_4687 | - | 4e-07 | 29.74% (195) | hypothetical protein MMAR_4687 |
| M. avium 104 | MAV_0938 | - | 4e-05 | 29.65% (172) | hypothetical protein MAV_0938 |
| M. smegmatis MC2 155 | MSMEG_0638 | - | 5e-06 | 35.59% (118) | hypothetical protein MSMEG_0638 |
| M. thermoresistible (build 8) | TH_3514 | - | 6e-06 | 27.01% (137) | PUTATIVE putative hypothetical protein Mflv_4945 |
| M. ulcerans Agy99 | MUL_0306 | - | 2e-06 | 29.65% (199) | hypothetical protein MUL_0306 |
| M. vanbaalenii PYR-1 | Mvan_6043 | - | 1e-148 | 48.55% (585) | hypothetical protein Mvan_6043 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3469c|M.bovis_AF2122/97 -------MADRLNVAERLAEGRPAAEHTQSYVRACHLVGYQHPDLTAYPA
Rv3439c|M.tuberculosis_H37Rv -------MADRLNVAERLAEGRPAAEHTQSYVRACHLVGYQHPDLTAYPA
TH_3514|M.thermoresistible__bu -------VTGGLDVAARLADGLPAVRAAQEYLSACESLGYRQPDLSGRPG
Mflv_0864|M.gilvum_PYR-GCK ---------------MSTHTHRRARRSEAFAVRRWLHAGAVTAGMG---A
Mvan_6043|M.vanbaalenii_PYR-1 -------MPQERELPLPQRRRRGARRAEDLPVRSWLKLGAASAGLG---A
MMAR_4687|M.marinum_M ------------MHAALLSGGCGVSTGIGNGAADSRSAPVDEDEIG---G
MUL_0306|M.ulcerans_Agy99 ---------------------------------------MDEDEIG---G
MAV_0938|M.avium_104 ----------------------------------MADAKKPPHDSA---T
MSMEG_0638|M.smegmatis_MC2_155 MSDPLGLSIGTTNLVAARVGNQPEIRRSVLTLSADRTPQVGVPESGAGVT
Mb3469c|M.bovis_AF2122/97 QIHDWYGSEDGLDLHALD----ADCAQLRAAASVLMEALRMERSQVAVLA
Rv3439c|M.tuberculosis_H37Rv QIHDWYGSEDGLDLHALD----ADCAQLRAAASVLMEALRMERSQVAVLA
TH_3514|M.thermoresistible__bu QVFDWYRSEDGLDLGALA----DDSAALDRAAARAAEVLELQDRQSAALG
Mflv_0864|M.gilvum_PYR-GCK ALLGFGVLAETATAAADP----GSE-SASAGATNAGPSAGEDGGSTAPDA
Mvan_6043|M.vanbaalenii_PYR-1 ALLGFALAGPSPMAEADT----GTETSVSTGPEKATAEQSGSGEADAPDD
MMAR_4687|M.marinum_M TAAEMRALAEEAEAEAAE----AEALAAAAGARARALQLRRRAERAEAAA
MUL_0306|M.ulcerans_Agy99 TAAEMRALADEAEAEAAE----AEAVAAAAGARARALQLRRRAERAEAAA
MAV_0938|M.avium_104 SDEDVKALLEEAEAEAAE----AEALAAAARARARAARLRREAQ-AQAAK
MSMEG_0638|M.smegmatis_MC2_155 LTGFVERVGDPVPLVAPDGASYPADTLLVEALDAMVEAAGGPSQQLVIAV
*
Mb3469c|M.bovis_AF2122/97 AAWTGSGADAAVHFVQRHCETGNSVVTEVRAAAQRCESLRDNLWQ--LVD
Rv3439c|M.tuberculosis_H37Rv AAWTGSGADAAVHFVQRHCETGNSVVTEVRAAAQRCESLRDNLWQ--LVD
TH_3514|M.thermoresistible__bu AGWRGVGGTAAAELLRRHGAASAAATAALRTAADALTTLRTELWQ--LVD
Mflv_0864|M.gilvum_PYR-GCK AT-----DADAATDADETDD----AAADADETADDDEAADDAAAE--EPD
Mvan_6043|M.vanbaalenii_PYR-1 AEDEANEDSDELDDADATDDPDDPDDADATDDVDDVDEADDAVGE--ATD
MMAR_4687|M.marinum_M EVDAACEATHEGAADGQATASHNGAEEPSANSADVLESDDVAETE--ELS
MUL_0306|M.ulcerans_Agy99 EVDAACEATHEGAADGQATASRNGAEEPTGNSADVLESDDVAETE--ELR
MAV_0938|M.avium_104 AAAETSEADEHAADDEPAET-----DDEVSDSVEATDADDTETTQ--AQT
MSMEG_0638|M.smegmatis_MC2_155 PAHWGPTTLRALRNALRTNPSLSHGGMPARLVPDAVASLAALRVNPGLPT
: :
Mb3469c|M.bovis_AF2122/97 SKVATAIAIDERALAQRPAWLAAAEALTTEGAD-----------------
Rv3439c|M.tuberculosis_H37Rv SKVATAIAIDERALAQRPAWLAAAEALTTEGAD-----------------
TH_3514|M.thermoresistible__bu RKVTATQGIDG---GGRTDWQAAAHTVLTGAGD-----------------
Mflv_0864|M.gilvum_PYR-GCK AEPVAVKPSTHRTKADTAVEAAVAEQVSSTALP-----GRAATQPPYVSE
Mvan_6043|M.vanbaalenii_PYR-1 GDRDDEGGEAAAGGADPAADGDVVTDLPALVESPPPTENSGATTESAASA
MMAR_4687|M.marinum_M ADDDEPAAAGSAEADESEAD------------------------------
MUL_0306|M.ulcerans_Agy99 ADDDEPVAAGSAKADESEAD------------------------------
MAV_0938|M.avium_104 KEAAKEAEPNEEAAEETAED------------------------------
MSMEG_0638|M.smegmatis_MC2_155 GGVVALVDFGGSGTSITLADAASGFEPIDETTRHPDFSGDQIDQALLTHV
Mb3469c|M.bovis_AF2122/97 --------------------------RPTAVEVVRQQIQPYVDDDVRNDW
Rv3439c|M.tuberculosis_H37Rv --------------------------RPTAVEVVRQQIQPYVDDDVRNDW
TH_3514|M.thermoresistible__bu --------------------------RSVASELVDAEVKPFVDEAIGCEW
Mflv_0864|M.gilvum_PYR-GCK QSAYEKR-----VAESLAAWTQRNQEWVDSLDVTDERKERMQESFVAMRT
Mvan_6043|M.vanbaalenii_PYR-1 QPATPKRPWRELVAGFIDDWTADTEAWIDSLDASDQTKERLEATFWAVRR
MMAR_4687|M.marinum_M -------------------------------ELADESERSRRGLLRRPKL
MUL_0306|M.ulcerans_Agy99 -------------------------------ELADESERSRRGLLRRPKL
MAV_0938|M.avium_104 -------------------------------AESESKARSRR-RLRLPSW
MSMEG_0638|M.smegmatis_MC2_155 LDGIAEAGG---IDPAGTAAVGSLARLREECRAAKERLSALTATDLAVEL
Mb3469c|M.bovis_AF2122/97 LTTMRSTTAGVAASYDAVTDQLASAPRAHFEIPDD----LGPGRQPSPAS
Rv3439c|M.tuberculosis_H37Rv LTTMRSTTAGVAASYDAVTDQLASAPRAHFEIPDD----LGPGRQPSPAS
TH_3514|M.thermoresistible__bu LTVMNQTLTSIEEKFDAAIAELTGS-----AAVPD----FGAGEGEAPPW
Mflv_0864|M.gilvum_PYR-GCK TFFNQAPTIAPVQITGVITGPVTGTIGAIDPDGDR----LRYVITRAPAT
Mvan_6043|M.vanbaalenii_PYR-1 TFFNQAPTVDPVQITGVITGPVTGTLGAVDPDGDR----VVYRLVRAPGQ
MMAR_4687|M.marinum_M STLTAALAVLVILAALAGSAYMVLQHRDATRQRER----VAEFAAAAR-Q
MUL_0306|M.ulcerans_Agy99 STLTAALAVLVILAALAGSAYMVLQHRDATRQRER----VAEFAAAAR-Q
MAV_0938|M.avium_104 SVAWKAAVIALICAFVAASGYMMWERHQTSERNQR----IANFLAAAR-Q
MSMEG_0638|M.smegmatis_MC2_155 PGYSATIRVTRDELETLMRPPLTGVLDTLDNALERNGFDWSAVAAVVTIG
:
Mb3469c|M.bovis_AF2122/97 VPAQPSATAAITPAAA-----LPPPDPVPAVTSRPVTPSDFGSAPGDGSA
Rv3439c|M.tuberculosis_H37Rv VPAQPSATAAITPAAA-----LPPPDPVPAVTSRPVTPSDFGSAPGDGSA
TH_3514|M.thermoresistible__bu AANWGPPWAANWGQPG-----AASWGSPPVADG---AASAIGADPAPAEA
Mflv_0864|M.gilvum_PYR-GCK GTVKINVDGTYTYTPGAEFDGVDAFHVRAIDLGLHVNLLQLLRPLGSGRA
Mvan_6043|M.vanbaalenii_PYR-1 GSVKVNSDGTFTYTPGSDFDGVDTFRVLAVDVGMHVNVLDWFRPWGT-RA
MMAR_4687|M.marinum_M GVITLTSLDFQDAKQG---------------------------------I
MUL_0306|M.ulcerans_Agy99 GVITLTSLDFQDAKQG---------------------------------I
MAV_0938|M.avium_104 GVVNMTSLDFNKAKED---------------------------------V
MSMEG_0638|M.smegmatis_MC2_155 GGASIPLVTQQLSEHSRAVVVTTPQPALDAAVGAALIAAGVTASAAADAE
Mb3469c|M.bovis_AF2122/97 TPAGVGSAGGFGDAGGTGGLGGFAGLAGLANRIVDAVDSLLGSVAEQLGD
Rv3439c|M.tuberculosis_H37Rv TPAGVGSAGGFGDAGGTGGLGGFAGLAGLANRIVDAVDSLLGSVAEQLGD
TH_3514|M.thermoresistible__bu AAPGVPPPAVPPTGPGGGLPDPGAGLSTVGRQLVDLLGGLLGPVGEALGN
Mflv_0864|M.gilvum_PYR-GCK TSLVNQGAVTFDFDFTTGSQYWTTPRREALQDAADDLVAYFRVTRPVTLT
Mvan_6043|M.vanbaalenii_PYR-1 TPLINQGAVTFDFRYETGAGHWSAERKAALLGAANELVSYLRVNAPVVIS
MMAR_4687|M.marinum_M GRILDNSTGSFKDELLKSSDDFIQVVQ------QAQVVEQGTVQAVAVDR
MUL_0306|M.ulcerans_Agy99 GRILDNSTGSFKDELLKSSDDFIQVVQ------QAQVVEQGTVQAVAVDR
MAV_0938|M.avium_104 QRVIDSSTGQFRDDFQQRAKDFTTVVE------QSKVVTQGTVNAAAVQ-
MSMEG_0638|M.smegmatis_MC2_155 AMTGAAPTLGVAAVSDTTGPDAATASAPAVGATPDQEGSSTFRALAWSED
.
Mb3469c|M.bovis_AF2122/97 PLAAD----NPPGAVDPFAEDAADNADDGDDAHPEEADEAAEPKEATEPD
Rv3439c|M.tuberculosis_H37Rv PLAAD----NPPGAVDPFAEDAADNADDGDDAHPEEADEAAEPKEATEPD
TH_3514|M.thermoresistible__bu GVGAAGV--DPMGGEDAGGEDAGTEERDGASDADTDAEDDDRGDDTPEDD
Mflv_0864|M.gilvum_PYR-GCK FEVEGSD--NASSSTLASAGSGTISRDPGYWRTVVQNKLLGGEDSNGEEA
Mvan_6043|M.vanbaalenii_PYR-1 YRVDGFD--DPTSALLAQAGSSYTSAEPGFWPTLVQNKLISGGDANGSAA
MMAR_4687|M.marinum_M NSMTDD------SAVVLVASTSEVTNAAGAKKDPRKYRLIVTITRDG---
MUL_0306|M.ulcerans_Agy99 NSMTDD------SAVVLVASTSEVTNAAGAKKDPRKYRLIVTITRDG---
MAV_0938|M.avium_104 -SIDGN------SALVLVAATSRITNAAGAKDEPRNWRLKVTVTDEG---
MSMEG_0638|M.smegmatis_MC2_155 EPADDVVPYAGPDVVNPYAANPYANPYAGDTSARPAVQYVPPTGPVEEPA
. . *
Mb3469c|M.bovis_AF2122/97 EADEVDDADESVPAERAQDVAE----------EATLPPVAEPPPPAAPPV
Rv3439c|M.tuberculosis_H37Rv EADEVDDADESVPAERAQDVAE----------EATLPPVAEPPPPAAPPV
TH_3514|M.thermoresistible__bu TPDDGDPDAGGSPGEDPQEAPD----------PEHDPDPAPGEPETHXXX
Mflv_0864|M.gilvum_PYR-GCK DGSINWNWGKGWEIGDEVPSDK----------FDFRAVAIHELLHAFGFT
Mvan_6043|M.vanbaalenii_PYR-1 DGLIQVNFGKKWSLDDTVESDE----------FDFMMALMHEMLHSFGIL
MMAR_4687|M.marinum_M ---------------DQLKMSK----------VEFVP-------------
MUL_0306|M.ulcerans_Agy99 ---------------DQLKMSK----------VEFVP-------------
MAV_0938|M.avium_104 ---------------GQYKMSK----------LEFVP-------------
MSMEG_0638|M.smegmatis_MC2_155 GGWKRLPLTVFGIAVAAVLVAVGGVTYALTSSTSSTPTTEVRTAEPKPLT
Mb3469c|M.bovis_AF2122/97 AEP-----------------------------------------------
Rv3439c|M.tuberculosis_H37Rv AEP-----------------------------------------------
TH_3514|M.thermoresistible__bu AGPGDVAIDFSGSTEALGEALDRLDVGGVLVLAGSVSPAPALPVDPELIV
Mflv_0864|M.gilvum_PYR-GCK SGTEEPGDRDRRHWYILDSFIVTRNGTSPISSDFEWLEEFDGYLEGEDGG
Mvan_6043|M.vanbaalenii_PYR-1 FAVR-PGETTRRYWSTYASLVVDENGSSPFNSDFSWNTAYDPNLTRKDGG
MMAR_4687|M.marinum_M --------------------------------------------------
MUL_0306|M.ulcerans_Agy99 --------------------------------------------------
MAV_0938|M.avium_104 --------------------------------------------------
MSMEG_0638|M.smegmatis_MC2_155 PEPEPSAVAPPPVAEPPPPVTEAPPPPPPVTITEVAPPPPVTETHVVTQT
Mb3469c|M.bovis_AF2122/97 ----------------------------------PPPVAAPAPPGAPEPA
Rv3439c|M.tuberculosis_H37Rv ----------------------------------PPPVAAPAPPGAPEPA
TH_3514|M.thermoresistible__bu RRWLTLTGVHNYEPQHLRDAVAF-LRHSRDRFDWPALVDDPVGLDDIAAA
Mflv_0864|M.gilvum_PYR-GCK LYWGGSHAEDAYGG-YVPIFTPDPWDEGSSGAHLDDWTFNDGDEKLMNAA
Mvan_6043|M.vanbaalenii_PYR-1 LFFGGTEAVEAYDGALIPLFTSDPWLGTSVGAHLDDMVFIGVDRKMMNAS
MMAR_4687|M.marinum_M --------------------------------------------------
MUL_0306|M.ulcerans_Agy99 --------------------------------------------------
MAV_0938|M.avium_104 --------------------------------------------------
MSMEG_0638|M.smegmatis_MC2_155 TTPPTTTTTTTTSPTTTEPTTTTTTPTTTETTTTTTTPTTTTNPMTTTYI
Mb3469c|M.bovis_AF2122/97 NGPSPE-----ALSEGATPCEIAADELPQAGP--------------
Rv3439c|M.tuberculosis_H37Rv NGPSPE-----ALSEGATPCEIAADELPQAGP--------------
TH_3514|M.thermoresistible__bu LMPAPTGRLRKAVSPGLPPRTAARNSPGSRPPDS------------
Mflv_0864|M.gilvum_PYR-GCK TSRGPSVRTLSDIELGILTDIGYLVYAKAD----------------
Mvan_6043|M.vanbaalenii_PYR-1 TTPGPGVRVLSAIELGILKDLGYQVVARTPVEDLA-----------
MMAR_4687|M.marinum_M ----------------------------------------------
MUL_0306|M.ulcerans_Agy99 ----------------------------------------------
MAV_0938|M.avium_104 ----------------------------------------------
MSMEG_0638|M.smegmatis_MC2_155 TVPFVPVPIPIQVPSREQPQPQYPPQYPQQYPQNPQYPQNPFQPYP