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MDLRGRTHLDPAGPYKRDPPAPHALTERCTSTADLIVLCHFGVPRVDRGSWSLRIEGLVHHPTTLTFDEL LRYPRTEITAVHQCSGSPFDPAVPTRRVGTATWAGARLADVLADCRPMPQARYIWSYGADGGTFAGAAVD SYCKDLPLSRVDADVLLCYEVNGEDLPAEHGFPVRLLIPGFYGTNSVKWLTTITLADRRAPGPFTAQWYQ DPPAAGSEDPHPVWSLAPESLIVAPAAGQSLHRDAEVAIWGWAWADGGVSQVDVGIGGSWHAAEVEGCRG WQWQRFSTAWTPSQPGTVEVAARATSSLGQVQPTSGHRNAVHSVMVDVRDEEPWT
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_5892 | - | - | 100% (335) | oxidoreductase, molybdopterin binding |
| M. vanbaalenii PYR-1 | Mvan_2026 | - | 7e-28 | 30.34% (323) | oxidoreductase, molybdopterin binding |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1786 | - | 2e-28 | 29.14% (326) | sulfite oxidase |
| M. gilvum PYR-GCK | Mflv_4320 | - | 2e-26 | 31.88% (276) | oxidoreductase, molybdopterin binding |
| M. tuberculosis H37Rv | Rv0218 | - | 5e-07 | 32.65% (98) | transmembrane protein |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4441 | - | 8e-17 | 27.01% (311) | putative oxidoreductase |
| M. marinum M | MMAR_3039 | - | 3e-28 | 32.33% (300) | membrane-bound oxidoreductase |
| M. avium 104 | MAV_2937 | - | 2e-11 | 27.22% (158) | oxidoreductase molybdopterin binding subunit |
| M. smegmatis MC2 155 | MSMEG_2278 | - | 4e-24 | 29.64% (280) | membrane-bound oxidoreductase |
| M. thermoresistible (build 8) | - | - | - | - | - |
| M. ulcerans Agy99 | MUL_2279 | - | 1e-28 | 32.33% (300) | membrane-bound oxidoreductase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_4320|M.gilvum_PYR-GCK ------------------------------MTTPGVR--AAGGVAAAAVA
MSMEG_2278|M.smegmatis_MC2_155 ------------------------------MSERVRRTPPLAGLAAAAVA
MMAR_3039|M.marinum_M ------------------------------MAGPSANERMLAGVAAASVA
MUL_2279|M.ulcerans_Agy99 MADATVPNALVCLCGGTFALAESGASRVAGMAGPSANERMLAGVAAASVA
MAB_4441|M.abscessus_ATCC_1997 ------------------------------MEHAARR--IIAGLIAAAAA
Mb1786|M.bovis_AF2122/97 --------------------------------------------------
Mvan_5892|M.vanbaalenii_PYR-1 --------------------------------------------------
Rv0218|M.tuberculosis_H37Rv ----------------------------------------MSDPARGAEA
MAV_2937|M.avium_104 ------------------------------MGTPLTSIPDYRNEIHTAED
Mflv_4320|M.gilvum_PYR-GCK VGVASLVGAAFGPEADVRTAVGSSVIDLTPGPVKEWAIATFGTADKLALA
MSMEG_2278|M.smegmatis_MC2_155 LGVAGIVAVPFGPAADSRTAVGSAVIDLTPGPVKEWAITTFGTADKLLLT
MMAR_3039|M.marinum_M LGVAQVVSIPFGTRADARTAVGSAVIDITPGPIKEWAIQALGPLDKPFLA
MUL_2279|M.ulcerans_Agy99 LGVAQVVSIPFGTRADARTAVGSAVIDITPGPIKEWAIQALGPLDKPFLA
MAB_4441|M.abscessus_ATCC_1997 LAVGQLAAAAVAPDSAPFYAVGNTVVDHTPAAVREWVIGIFGTSDKAVLF
Mb1786|M.bovis_AF2122/97 --------------------------------------------------
Mvan_5892|M.vanbaalenii_PYR-1 --------------------------------------------------
Rv0218|M.tuberculosis_H37Rv EDAYGFPAGLWRWLQRHPPPALHRLTRFRSPLRGPWLTSVFG-------L
MAV_2937|M.avium_104 VIDVEAYGGGFDLTRRATAPKLRVGRDRWFNLLWLIPIGFALLIAGVAVG
Mflv_4320|M.gilvum_PYR-GCK VMVLLTIAAIAAVAGLAETRRRPVCSIAIVIAGGIGCAAVLSRAGSTGAD
MSMEG_2278|M.smegmatis_MC2_155 VLIIAIIATLAAVTAPLETRRRPVGSIVIGLAGVLGCVAVLSRPGAGWVA
MMAR_3039|M.marinum_M IVVLVVIATLAALAGTLETQRRPLGSAVIAAAGVLGCAAVLSRQGGTLLD
MUL_2279|M.ulcerans_Agy99 IVVLVVIATLAALAGTLETQRRPLGSAVIAAAGVLGCAAVLSRQGGTLLD
MAB_4441|M.abscessus_ATCC_1997 ACLTVIIALLAALAGLVEGERR-YGTVLIGLLGVFGAVAAVTRPAGTFAW
Mb1786|M.bovis_AF2122/97 ---------------MTDRGENRTTIAMLETAGLWGKRADMIVRG-----
Mvan_5892|M.vanbaalenii_PYR-1 --------------------MDLRGRTHLDPAG-----------------
Rv0218|M.tuberculosis_H37Rv VLLVALPFVIITGLLSYIAYAPQLGQAIPGDVGWLRLPAFTWPTRP----
MAV_2937|M.avium_104 KGLHNMPAVQSFIQRYPGTDSAGVPPGLPAWIGWTHFFNLFMMMFIIRTG
*
Mflv_4320|M.gilvum_PYR-GCK IIPTLIGTACGVAVLRILQSDRLDGP------------------SSETGT
MSMEG_2278|M.smegmatis_MC2_155 ILPTVIGAVCGIAALRLLTSDRFRDEQAVAEDRADQRADRYADDHADDTV
MMAR_3039|M.marinum_M TIPTIAGAACGVLLLRVLMRRFWPDAED--------------PNGSGDKS
MUL_2279|M.ulcerans_Agy99 TIPTIAGAACGVLLLRVLMRRFWPDAED--------------PNGSGDQS
MAB_4441|M.abscessus_ATCC_1997 IWPSVIAAVAGALVLGTLVHR------------------------AQSQA
Mb1786|M.bovis_AF2122/97 --------------------------------------------------
Mvan_5892|M.vanbaalenii_PYR-1 --------------------------------------------------
Rv0218|M.tuberculosis_H37Rv --------------------------------------------------
MAV_2937|M.avium_104 IQILCDHPRLYFSRNATPGKDEWLRVGP---------------------P
Mflv_4320|M.gilvum_PYR-GCK DPGRRRSLLTIGLLAAGAVSGVAGVVISRLASSVAGDRDAFALPRIDTPA
MSMEG_2278|M.smegmatis_MC2_155 DPGRRWSLVALGLLTTGVVTGAAGAVLSRLASSVAGDRDAFTLPRAARAA
MMAR_3039|M.marinum_M DAGRRR-LIMLGLLGFGVVTGVTGAVLARLAHSVAADRKAFTLPQPGTTA
MUL_2279|M.ulcerans_Agy99 DAGRRR-LVMLGLLGFGVVTGVTGAVLVRLAHSVAADRKAFTLPQPGTTA
MAB_4441|M.abscessus_ATCC_1997 VPDRRRFFGTAAVFALGSAGLYWLGTRWSKGTVVAAERREATVPAPVAPA
Mb1786|M.bovis_AF2122/97 -----------------------------------------CLPYNAEPP
Mvan_5892|M.vanbaalenii_PYR-1 -------------------------------------------PYKRDPP
Rv0218|M.tuberculosis_H37Rv -----------------------------------------SWLYRLTQG
MAV_2937|M.avium_104 VPDDELWTANADTVALPPQFGLPGFRHSIGLARWWHLGVDVLWLLNGAVF
Mflv_4320|M.gilvum_PYR-GCK APIPESVQPKGVELPSWVTGNDDFYRIDTALSVPQLSRSEWRLRIHG---
MSMEG_2278|M.smegmatis_MC2_155 APIPPDVQPAGVSLPSFITPTPKFYRIDTALTVPQLTRDEWQLRIHG---
MMAR_3039|M.marinum_M PPIPADVQPKGVALPDFITPSADFYRIDTALVVPQLSRGDWRLRIHG---
MUL_2279|M.ulcerans_Agy99 PPIPADVKPKGVALPDFITPSADFYRINTALVVPQLSRGDWRLRIHG---
MAB_4441|M.abscessus_ATCC_1997 PPLPEGIDVKGAVP--YITSNTDFYRIDTALRVPQVSTAEWQLNIHG---
Mb1786|M.bovis_AF2122/97 PAVLAGSD---------ITPINAFY-VRNHGPVPDIAPQHWRLTVGG---
Mvan_5892|M.vanbaalenii_PYR-1 APHALTER----------CTSTADLIVLCHFGVPRVDRGSWSLRIEG---
Rv0218|M.tuberculosis_H37Rv LHVGLGLVIIPVVLAKLWSVIPRLFVWPPARSIAQVLERLSVLMLVGGIL
MAV_2937|M.avium_104 YVLLFATGQWRHIVPTSWDVFPNAASVAVQYLSLDWPTDNGWVAYNGLQL
: *
Mflv_4320|M.gilvum_PYR-GCK --MVDREVTFTYEDLD--RFEVVEKVITLTCVSN---------------P
MSMEG_2278|M.smegmatis_MC2_155 --MTDREVTYRFEDLD--RFEVVEKVVTLTCVSN---------------F
MMAR_3039|M.marinum_M --MVDREISYTFDDLT--QFDVVETVATLTCVSN---------------P
MUL_2279|M.ulcerans_Agy99 --MVDREISYTFDDLT--QFDVVETVATLTCVSN---------------P
MAB_4441|M.abscessus_ATCC_1997 --MVDRPRTLMWADLN--AMAATQRAVTLTCVSN---------------E
Mb1786|M.bovis_AF2122/97 --LVDNPLTVTYERLTT-EFDQHCVVATLACAGNRRAELLRVRQIPGKEP
Mvan_5892|M.vanbaalenii_PYR-1 --LVHHPTTLTFDELL--RYPRTEITAVHQCSGS-----------PFDPA
Rv0218|M.tuberculosis_H37Rv FQIVTGVLNIQYDYIFGFSFYTGHYFGAWVFIAG--------------FL
MAV_2937|M.avium_104 LSYFTTVFIAAPAALITGLGMSPALSQRVHWLSKR-------LSIQHARS
: .
Mflv_4320|M.gilvum_PYR-GCK VGGELISNAVWTGYRVKDLLAEAGVRSGADMVLSMSVDGWTAGT-PVEAL
MSMEG_2278|M.smegmatis_MC2_155 VGGDLISNATWTGYRVRDLLEEAGVSTDSDMALSTSIDGFTAGS-PIEAL
MMAR_3039|M.marinum_M VGGNLISTGIWTGYRVADLLSAAGVHKDADMVLSTSIDGFTAGT-PVQAL
MUL_2279|M.ulcerans_Agy99 VGGNLISTGIWTGYRIADLLSAAGVHKDADMVLSTSIDGFTAGT-PVQTL
MAB_4441|M.abscessus_ATCC_1997 IGGNLIGNAVWTGFPIKPILESVGVHPDADMLLSKSVDGWTAGT-PLQVL
Mb1786|M.bovis_AF2122/97 WAHGAISTAQWCGVRLADILQAADVHIDEGLHVAFDAPDVAEEARPIQPY
Mvan_5892|M.vanbaalenii_PYR-1 VPTRRVGTATWAGARLADVLADCRPMPQARYIWSYGADGGTFAGAAVDSY
Rv0218|M.tuberculosis_H37Rv LHIVVKIPHMVTGLRSIPMREVLGTNVADTRAQPCDPDGLVSVNPGEATL
MAV_2937|M.avium_104 LHFLVLVYFLFFILVHVTMVLTTSALRNLNHMFAARDDNSWIGFGIFSAA
: . .
Mflv_4320|M.gilvum_PYR-GCK TGD---------DALLAIGMNGEPLPIEHGYPARLVVPGLYGYVSATKWV
MSMEG_2278|M.smegmatis_MC2_155 TDDR--------DALLAIGMNGEPLPAAHGYPARLVVPGLYGYVSATKWV
MMAR_3039|M.marinum_M TDGR--------EALLALGLNGQPLPVEHGYPARLVVPGLYGYVSATKWV
MUL_2279|M.ulcerans_Agy99 TDGR--------EALLALGLNGQPLPVEHGYPARLVVPGLYGYVSATKWV
MAB_4441|M.abscessus_ATCC_1997 TDGR--------DAILAIAMNGTPLPVEHGYPVRQVVPGLYGYVSATKWV
Mb1786|M.bovis_AF2122/97 GSSIPLSKALSPEVLLAWQMNSEPLPRAHGGPVRVVVPGFIG-ARSVKWV
Mvan_5892|M.vanbaalenii_PYR-1 CKDLPLSR-VDADVLLCYEVNGEDLPAEHGFPVRLLIPGFYG-TNSVKWL
Rv0218|M.tuberculosis_H37Rv SRRGALGLVGAGVLLIGVLTVGQTLGGFTRKAALLLPRGRVVSPGDFPVN
MAV_2937|M.avium_104 MVLTAIAWVWATPFTIRHPRVVQRVGYALVGPFQRMLEQLDPKPGAFTEK
: : . :
Mflv_4320|M.gilvum_PYR-GCK TALELT-------------RFDRAQA-YWTRLG---WSARGPIKTASRVD
MSMEG_2278|M.smegmatis_MC2_155 VDLELT-------------RFDRAEA-YWTKLG---WSAHGPIKTQSRID
MMAR_3039|M.marinum_M VELELT-------------RFDRAKA-YWTRQG---WAARAPIKTESRID
MUL_2279|M.ulcerans_Agy99 VELELT-------------RFDRAKA-YWTRQG---WAARAPIKTESRID
MAB_4441|M.abscessus_ATCC_1997 VDWEIT-------------RFDKADA-YWTIRG---WSARGPIKTGCRID
Mb1786|M.bovis_AF2122/97 TAITVQPGASQNYFQALDYRILPADA-DADIVGPGEGISLSSLALNCDIL
Mvan_5892|M.vanbaalenii_PYR-1 TTITLADRRAPG------PFTAQWYQ-DPPAAGSEDPHPVWSLAPESLIV
Rv0218|M.tuberculosis_H37Rv KTAAAAG-----------ITAEAIGP-DWRLVLCG-GPAEVVLDRATLAG
MAV_2937|M.avium_104 DISPHHWRNGRLPETVEYKELEANDFKDWRLKVYGLVEHPMEFSLEDLMA
:
Mflv_4320|M.gilvum_PYR-GCK VPRSGQDVA-LGPVTFGGVAWAQN-RGVRSVEVQMDD----GPWEQATLG
MSMEG_2278|M.smegmatis_MC2_155 VPREGQQVP-RGPVRFGGVAWAQH-RGIRAVEVKIDGPSDPGEWQQAQLG
MMAR_3039|M.marinum_M VPRRGQKVP-VGPVVFGGVAWAQN-RGVRAVEVRIGD----GGWQRAELG
MUL_2279|M.ulcerans_Agy99 VPKRGQKVP-VGPVVFGGVAWAQN-RGVRAVEVRIGD----GGWQRAELG
MAB_4441|M.abscessus_ATCC_1997 TPRTGDRLG-TGTQIVAGTAWAQH-RGIATVEVQIDD----GPWLPARLA
Mb1786|M.bovis_AF2122/97 DPTDGDDVP-AGALTIRGYGMAGDGRSVERVDVSVDDG---LTWQQADLH
Mvan_5892|M.vanbaalenii_PYR-1 APAAGQSLHRDAEVAIWGWAWADG--GVSQVDVGIGG-----SWHAAEVE
Rv0218|M.tuberculosis_H37Rv LPQRTARLP---LACVEGWSAVRTWSGVPLAELALLAG--VPAARSARVT
MAV_2937|M.avium_104 LPYHEQISQHFCIQAWSGVAKWGGVQMKTIMDIVKPLP--EAKWAVFYSM
* * . ::
Mflv_4320|M.gilvum_PYR-GCK DSYSGDTWRMWSYAWEARDTGFHTITVRATDDSGYTQTP---DRADPVPD
MSMEG_2278|M.smegmatis_MC2_155 AAYSDDTWRLWSVDWTAADPGEHTITVRATDNTGETQTP---DLADPVPD
MMAR_3039|M.marinum_M ASYSNATWRLWSLPWQAKSPGTHTITVRAIDNTGAVQTE---DRADPVPD
MUL_2279|M.ulcerans_Agy99 ASYSNATWRLWSLPWQAKSPGTHTITVRAIDNTGAVQTE---DRADPVPD
MAB_4441|M.abscessus_ATCC_1997 PEYSVDTWRQWWFAWQAT-AGEHIITARATDGTGAVQTD---QIASPVPD
Mb1786|M.bovis_AF2122/97 AAPSQWSWRPWSLTVDVE-PGPLGITARAWDDTGALQPESAVSLWNPRGY
Mvan_5892|M.vanbaalenii_PYR-1 GCRG-WQWQRFSTAWTPSQPGTVEVAARATSSLGQVQPTS--GHRNAVHS
Rv0218|M.tuberculosis_H37Rv SLQRGGAFGEAKLAANQIADPDALLALRVDGADLSLDHGYPARIIVPALP
MAV_2937|M.avium_104 GLGATGGIYYNAHHIGQMDHHMTMLAYKMNDQQLPYMHGRPLRLRNELQH
:: : .
Mflv_4320|M.gilvum_PYR-GCK GATGWHSITFAVK---------------------------
MSMEG_2278|M.smegmatis_MC2_155 GATGWHYVTFDVT---------------------------
MMAR_3039|M.marinum_M GATGWHTVTFTVVDK-------------------------
MUL_2279|M.ulcerans_Agy99 GATGWHTVTFTVVDK-------------------------
MAB_4441|M.abscessus_ATCC_1997 GATGYPKRLVTVAA--------------------------
Mb1786|M.bovis_AF2122/97 GNNAWARVALRVS---------------------------
Mvan_5892|M.vanbaalenii_PYR-1 VMVDVRDEEPWT----------------------------
Rv0218|M.tuberculosis_H37Rv GVHNTKWVAGIEFHKR------------------------
MAV_2937|M.avium_104 GFKLVKWIKGIEFVADYRDIGSGYGGYSEDHKYFGRHQTL