For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
TTPGAKAMTGVAAAAVAVGVAQLVGAAFGPQADVRTAVGSAVIELTPGAVKEWAIDTFGTADKLALTVMV LAVIAVIAAVAGILESRRRPIGSTAIVAAGGVGCAAVLSRAGATLVDIVPTLVGTACGVAVLRLLVSGRF TDEGEEASTDQGRRLSLVTLGLLGAGVASGALGVVITRLASSVSGDREAFALPKVNKAAAPIPDGVQPKG VALPSFVTSNSDFYRIDTALSVPQLSRQDWRLRIHGMVDREVTYRYEDLSRFEVVEKVVTLTCVSNPVGG ELISNAVWTGYRVGDLLAEAGVQPDADMVLSMSVDGWSAGTPVEALTDGDALLAIGMNGEPLPIEHGYPA RLVVPGLYGYVSATKWVTDLELTRFDRAEAYWTRLGWSARGPIKTESRIDVPRSGQDVPVGPVTFGGVAW AQDRGIRAVEVQIDDGDWRQATLGDAYSGDTWRLWSFPWDARETGFHTITVRATDNDGYTQTPDRADPVP DGATGWHSITFAVR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_2026 | - | - | 100% (505) | oxidoreductase, molybdopterin binding |
| M. vanbaalenii PYR-1 | Mvan_5892 | - | 1e-27 | 30.34% (323) | oxidoreductase, molybdopterin binding |
| M. vanbaalenii PYR-1 | Mvan_0889 | - | 8e-11 | 31.16% (138) | oxidoreductase, molybdopterin binding |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1786 | - | 8e-28 | 30.75% (361) | sulfite oxidase |
| M. gilvum PYR-GCK | Mflv_4320 | - | 0.0 | 81.19% (505) | oxidoreductase, molybdopterin binding |
| M. tuberculosis H37Rv | Rv0218 | - | 5e-09 | 29.82% (218) | transmembrane protein |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4441 | - | 1e-130 | 50.40% (494) | putative oxidoreductase |
| M. marinum M | MMAR_3039 | - | 0.0 | 66.80% (512) | membrane-bound oxidoreductase |
| M. avium 104 | MAV_2997 | - | 1e-09 | 36.64% (131) | oxidoreductase, molybdopterin binding |
| M. smegmatis MC2 155 | MSMEG_2278 | - | 0.0 | 69.75% (519) | membrane-bound oxidoreductase |
| M. thermoresistible (build 8) | - | - | - | - | - |
| M. ulcerans Agy99 | MUL_2279 | - | 0.0 | 66.02% (512) | membrane-bound oxidoreductase |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_2026|M.vanbaalenii_PYR-1 --------------------------------MTTPGAKAMTGVAAAAVA
Mflv_4320|M.gilvum_PYR-GCK --------------------------------MTTPGVRAAGGVAAAAVA
MSMEG_2278|M.smegmatis_MC2_155 ------------------------------MSERVRRTPPLAGLAAAAVA
MMAR_3039|M.marinum_M ------------------------------MAGPSANERMLAGVAAASVA
MUL_2279|M.ulcerans_Agy99 MADATVPNALVCLCGGTFALAESGASRVAGMAGPSANERMLAGVAAASVA
MAB_4441|M.abscessus_ATCC_1997 --------------------------------MEHAARRIIAGLIAAAAA
Rv0218|M.tuberculosis_H37Rv ----------------------------------------MSDPARGAEA
MAV_2997|M.avium_104 -----------------------------------------MKPTR----
Mb1786|M.bovis_AF2122/97 --------------------------------------------------
Mvan_2026|M.vanbaalenii_PYR-1 VGVAQLVGAAFGPQADVRTAVGSAVIELTPGAVKEWAIDTFGTADKLALT
Mflv_4320|M.gilvum_PYR-GCK VGVASLVGAAFGPEADVRTAVGSSVIDLTPGPVKEWAIATFGTADKLALA
MSMEG_2278|M.smegmatis_MC2_155 LGVAGIVAVPFGPAADSRTAVGSAVIDLTPGPVKEWAITTFGTADKLLLT
MMAR_3039|M.marinum_M LGVAQVVSIPFGTRADARTAVGSAVIDITPGPIKEWAIQALGPLDKPFLA
MUL_2279|M.ulcerans_Agy99 LGVAQVVSIPFGTRADARTAVGSAVIDITPGPIKEWAIQALGPLDKPFLA
MAB_4441|M.abscessus_ATCC_1997 LAVGQLAAAAVAPDSAPFYAVGNTVVDHTPAAVREWVIGIFGTSDKAVLF
Rv0218|M.tuberculosis_H37Rv EDAYGFPAGLWRWLQRHPPPALHRLTRFRSPLRGPWLTSVFGLVLLVALP
MAV_2997|M.avium_104 TTGRSFPERLWR-----------------SPLRGPWLTSVFGSILLVTLP
Mb1786|M.bovis_AF2122/97 ---------------------------MTDRGENRTTIAMLETAGLWGKR
:
Mvan_2026|M.vanbaalenii_PYR-1 VMVLAVIAVIAAVAGILESRRRPIGSTAIVAAGGVGCAAVLSRAGATLVD
Mflv_4320|M.gilvum_PYR-GCK VMVLLTIAAIAAVAGLAETRRRPVCSIAIVIAGGIGCAAVLSRAGSTGAD
MSMEG_2278|M.smegmatis_MC2_155 VLIIAIIATLAAVTAPLETRRRPVGSIVIGLAGVLGCVAVLSRPGAGWVA
MMAR_3039|M.marinum_M IVVLVVIATLAALAGTLETQRRPLGSAVIAAAGVLGCAAVLSRQGGTLLD
MUL_2279|M.ulcerans_Agy99 IVVLVVIATLAALAGTLETQRRPLGSAVIAAAGVLGCAAVLSRQGGTLLD
MAB_4441|M.abscessus_ATCC_1997 ACLTVIIALLAALAGLVEGERR-YGTVLIGLLGVFGAVAAVTRPAGTFAW
Rv0218|M.tuberculosis_H37Rv FVIITGLLSYIAYA-------PQLGQAIPGDVGWLRLPAFTWPTRPSWLY
MAV_2997|M.avium_104 VVIVTGLLSYIAYG-------PRFGQAVPAEVGWLRLPVFDWPTDPSWLY
Mb1786|M.bovis_AF2122/97 ADMIVRGCLPYNAE---------PPPAVLAGSDITPINAFYVRNHGPVPD
: . .
Mvan_2026|M.vanbaalenii_PYR-1 IVPTLVGTACGVAVLRLLVSGRFTDE------------------GEEAST
Mflv_4320|M.gilvum_PYR-GCK IIPTLIGTACGVAVLRILQSDRLDGP------------------SSETGT
MSMEG_2278|M.smegmatis_MC2_155 ILPTVIGAVCGIAALRLLTSDRFRDEQAVAEDRADQRADRYADDHADDTV
MMAR_3039|M.marinum_M TIPTIAGAACGVLLLRVLMRRFWPDAED--------------PNGSGDKS
MUL_2279|M.ulcerans_Agy99 TIPTIAGAACGVLLLRVLMRRFWPDAED--------------PNGSGDQS
MAB_4441|M.abscessus_ATCC_1997 IWPSVIAAVAGALVLGTLVHR------------------------AQSQA
Rv0218|M.tuberculosis_H37Rv RLTQGLHVGLGLVIIPVVLAKLWS----------------------VIPR
MAV_2997|M.avium_104 RATQGLHVGLGLVLIPVVLAKLWS----------------------VIPR
Mb1786|M.bovis_AF2122/97 IAPQHWRLTVGGLVDNPLTVTYER--------------------------
. * :
Mvan_2026|M.vanbaalenii_PYR-1 DQGRRLSLVTLGLLGAGVASGALGVVITRLASSVSGDREAFALPKVNKAA
Mflv_4320|M.gilvum_PYR-GCK DPGRRRSLLTIGLLAAGAVSGVAGVVISRLASSVAGDRDAFALPRIDTPA
MSMEG_2278|M.smegmatis_MC2_155 DPGRRWSLVALGLLTTGVVTGAAGAVLSRLASSVAGDRDAFTLPRAARAA
MMAR_3039|M.marinum_M DAGRRR-LIMLGLLGFGVVTGVTGAVLARLAHSVAADRKAFTLPQPGTTA
MUL_2279|M.ulcerans_Agy99 DAGRRR-LVMLGLLGFGVVTGVTGAVLVRLAHSVAADRKAFTLPQPGTTA
MAB_4441|M.abscessus_ATCC_1997 VPDRRRFFGTAAVFALGSAGLYWLGTRWSKGTVVAAERREATVPAPVAPA
Rv0218|M.tuberculosis_H37Rv LFVWPPARSIAQVLERLSVLMLVGGILFQIVTGVLNIQYDYIFGFSFYTG
MAV_2997|M.avium_104 LFAWPPARSIAQLLERVSVLMLVGGILFEMVTGVLNIQYDYIFGFSFYTA
Mb1786|M.bovis_AF2122/97 -------------LTTEFDQHCVVATLACAGNRRAELLRVRQIPGKEPWA
: . .
Mvan_2026|M.vanbaalenii_PYR-1 APIPDGVQPKGVALPSFVTSNSDFYRIDTALSVPQLSRQDWRLRIHGMVD
Mflv_4320|M.gilvum_PYR-GCK APIPESVQPKGVELPSWVTGNDDFYRIDTALSVPQLSRSEWRLRIHGMVD
MSMEG_2278|M.smegmatis_MC2_155 APIPPDVQPAGVSLPSFITPTPKFYRIDTALTVPQLTRDEWQLRIHGMTD
MMAR_3039|M.marinum_M PPIPADVQPKGVALPDFITPSADFYRIDTALVVPQLSRGDWRLRIHGMVD
MUL_2279|M.ulcerans_Agy99 PPIPADVKPKGVALPDFITPSADFYRINTALVVPQLSRGDWRLRIHGMVD
MAB_4441|M.abscessus_ATCC_1997 PPLPEGIDVKGAVP--YITSNTDFYRIDTALRVPQVSTAEWQLNIHGMVD
Rv0218|M.tuberculosis_H37Rv HYFGAWVFIAGFLLHIVVKIPHMVTGLRSIPMREVLGTN-------VADT
MAV_2997|M.avium_104 HYFGAWVFVIGFLMHVTIKGRRMWAGLRSMSMRAVLRTP-------AADT
Mb1786|M.bovis_AF2122/97 HGAISTAQWCGVRLADILQAAD------------------------VHID
* :
Mvan_2026|M.vanbaalenii_PYR-1 REVTYRYEDLSRFEVVEKVVTLTCVSNPVGGELISNAVWTGYRVGDLLAE
Mflv_4320|M.gilvum_PYR-GCK REVTFTYEDLDRFEVVEKVITLTCVSNPVGGELISNAVWTGYRVKDLLAE
MSMEG_2278|M.smegmatis_MC2_155 REVTYRFEDLDRFEVVEKVVTLTCVSNFVGGDLISNATWTGYRVRDLLEE
MMAR_3039|M.marinum_M REISYTFDDLTQFDVVETVATLTCVSNPVGGNLISTGIWTGYRVADLLSA
MUL_2279|M.ulcerans_Agy99 REISYTFDDLTQFDVVETVATLTCVSNPVGGNLISTGIWTGYRIADLLSA
MAB_4441|M.abscessus_ATCC_1997 RPRTLMWADLNAMAATQRAVTLTCVSNEIGGNLIGNAVWTGFPIKPILES
Rv0218|M.tuberculosis_H37Rv RAQPCDPDGLVSVNPGEATLSRRGALGLVGAGVLLIGVLTVG-----QTL
MAV_2997|M.avium_104 EPEPWRPGGLAAAEPGPATMSRRGALALVGGGALFLALITAG-----QTL
Mb1786|M.bovis_AF2122/97 EGLHVAFDAPDVAEEARPIQPYG---------------------------
. .
Mvan_2026|M.vanbaalenii_PYR-1 AGVQPDADMVLSMSVDGWSAGTPVEALTDG-DALLAIGMNGEPLPIEHGY
Mflv_4320|M.gilvum_PYR-GCK AGVRSGADMVLSMSVDGWTAGTPVEALTGD-DALLAIGMNGEPLPIEHGY
MSMEG_2278|M.smegmatis_MC2_155 AGVSTDSDMALSTSIDGFTAGSPIEALTDDRDALLAIGMNGEPLPAAHGY
MMAR_3039|M.marinum_M AGVHKDADMVLSTSIDGFTAGTPVQALTDGREALLALGLNGQPLPVEHGY
MUL_2279|M.ulcerans_Agy99 AGVHKDADMVLSTSIDGFTAGTPVQTLTDGREALLALGLNGQPLPVEHGY
MAB_4441|M.abscessus_ATCC_1997 VGVHPDADMLLSKSVDGWTAGTPLQVLTDGRDAILAIAMNGTPLPVEHGY
Rv0218|M.tuberculosis_H37Rv GGFTRKAALLLP--RGRVVSPGDFPVNKTAAAAGITAEAIGPDWRLVLCG
MAV_2997|M.avium_104 GGRTRPAALLLPHGRGRGSGANDFDVNRTAAAAGIAAADIGARWRLTLGG
Mb1786|M.bovis_AF2122/97 SSIPLSKALSPEVLLAWQMNSEPLPRAHGGPVRVVVPGFIG-----ARSV
. : . :. *
Mvan_2026|M.vanbaalenii_PYR-1 PARLVVPGLYGYVSATKWVTDLELTRFDRAEAYWTRLGWSARGPIKTESR
Mflv_4320|M.gilvum_PYR-GCK PARLVVPGLYGYVSATKWVTALELTRFDRAQAYWTRLGWSARGPIKTASR
MSMEG_2278|M.smegmatis_MC2_155 PARLVVPGLYGYVSATKWVVDLELTRFDRAEAYWTKLGWSAHGPIKTQSR
MMAR_3039|M.marinum_M PARLVVPGLYGYVSATKWVVELELTRFDRAKAYWTRQGWAARAPIKTESR
MUL_2279|M.ulcerans_Agy99 PARLVVPGLYGYVSATKWVVELELTRFDRAKAYWTRQGWAARAPIKTESR
MAB_4441|M.abscessus_ATCC_1997 PVRQVVPGLYGYVSATKWVVDWEITRFDKADAYWTIRGWSARGPIKTGCR
Rv0218|M.tuberculosis_H37Rv GPAEVVLDRATLAGLPQRTARLPLA---CVEGWSAVRTWSGVPLAELALL
MAV_2997|M.avium_104 GARPVVLDRASLLAMPQHTAVLPIA---CVEGWSTTQAWTGVRLADLARL
Mb1786|M.bovis_AF2122/97 KWVTAITVQPGASQNYFQALDYRILPADADADIVGPGEGISLSSLALNCD
.: . : .
Mvan_2026|M.vanbaalenii_PYR-1 IDVPRSGQDVPVGPVTFGGVAWAQD-RGIRAVEVQIDD----GDWRQATL
Mflv_4320|M.gilvum_PYR-GCK VDVPRSGQDVALGPVTFGGVAWAQN-RGVRSVEVQMDD----GPWEQATL
MSMEG_2278|M.smegmatis_MC2_155 IDVPREGQQVPRGPVRFGGVAWAQH-RGIRAVEVKIDGPSDPGEWQQAQL
MMAR_3039|M.marinum_M IDVPRRGQKVPVGPVVFGGVAWAQN-RGVRAVEVRIGD----GGWQRAEL
MUL_2279|M.ulcerans_Agy99 IDVPKRGQKVPVGPVVFGGVAWAQN-RGVRAVEVRIGD----GGWQRAEL
MAB_4441|M.abscessus_ATCC_1997 IDTPRTGDRLGTGTQIVAGTAWAQH-RGIATVEVQIDD----GPWLPARL
Rv0218|M.tuberculosis_H37Rv AGVPAARSARVTSLQRGGAFGEAKL-AANQIADP-------------DAL
MAV_2997|M.avium_104 AGVPAPRSARVSSVERVGAFNAATL-HGSQVLHP-------------DAL
Mb1786|M.bovis_AF2122/97 ILDPTDGDDVPAGALTIRGYGMAGDGRSVERVDVSVDDG---LTWQQADL
* . . . * . . *
Mvan_2026|M.vanbaalenii_PYR-1 GDAYSGDTWRLWSFPWDARETGFHTITVRATDNDGYTQTPDRA---DPVP
Mflv_4320|M.gilvum_PYR-GCK GDSYSGDTWRMWSYAWEARDTGFHTITVRATDDSGYTQTPDRA---DPVP
MSMEG_2278|M.smegmatis_MC2_155 GAAYSDDTWRLWSVDWTAADPGEHTITVRATDNTGETQTPDLA---DPVP
MMAR_3039|M.marinum_M GASYSNATWRLWSLPWQAKSPGTHTITVRAIDNTGAVQTEDRA---DPVP
MUL_2279|M.ulcerans_Agy99 GASYSNATWRLWSLPWQAKSPGTHTITVRAIDNTGAVQTEDRA---DPVP
MAB_4441|M.abscessus_ATCC_1997 APEYSVDTWRQWWFAWQAT-AGEHIITARATDGTGAVQTDQIA---SPVP
Rv0218|M.tuberculosis_H37Rv LALRVDGADLSLDHGYPARIIVPALPGVHNTKWVAGIEFHKR--------
MAV_2997|M.avium_104 LALRVNGAELSVDHGFPARIVVPALPGVHNTKWVGAIDFRAGS---DA--
Mb1786|M.bovis_AF2122/97 HAAPSQWSWRPWSLTVDVE-PGPLGITARAWDDTGALQPESAVSLWNPRG
: . .: . . :
Mvan_2026|M.vanbaalenii_PYR-1 DGATGWHSITFAVR--
Mflv_4320|M.gilvum_PYR-GCK DGATGWHSITFAVK--
MSMEG_2278|M.smegmatis_MC2_155 DGATGWHYVTFDVT--
MMAR_3039|M.marinum_M DGATGWHTVTFTVVDK
MUL_2279|M.ulcerans_Agy99 DGATGWHTVTFTVVDK
MAB_4441|M.abscessus_ATCC_1997 DGATGYPKRLVTVAA-
Rv0218|M.tuberculosis_H37Rv ----------------
MAV_2997|M.avium_104 ----------------
Mb1786|M.bovis_AF2122/97 YGNNAWARVALRVS--