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VGTPLTSIPDYRNEIHTAEDVIDVEAYGGGFDLTRRATAPKLRVGRDRWFNLLWLIPIGFALLIAGVAVG KGLHNMPAVQSFIQRYPGTDSAGVPPGLPAWIGWTHFFNLFMMMFIIRTGIQILCDHPRLYFSRNATPGK DEWLRVGPPVPDDELWTANADTVALPPQFGLPGFRHSIGLARWWHLGVDVLWLLNGAVFYVLLFATGQWR HIVPTSWDVFPNAASVAVQYLSLDWPTDNGWVAYNGLQLLSYFTTVFIAAPAALITGLGMSPALSQRVHW LSKRLSIQHARSLHFLVLVYFLFFILVHVTMVLTTSALRNLNHMFAARDDNSWIGFGIFSAAMVLTAIAW VWATPFTIRHPRVVQRVGYALVGPFQRMLEQLDPKPGAFTEKDISPHHWRNGRLPETVEYKELEANDFKD WRLKVYGLVEHPMEFSLEDLMALPYHEQISQHFCIQAWSGVAKWGGVQMKTIMDIVKPLPEAKWAVFYSM GLGATGGIYYNAHHIGQMDHHMTMLAYKMNDQQLPYMHGRPLRLRNELQHGFKLVKWIKGIEFVADYRDI GSGYGGYSEDHKYFGRHQTL
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_2937 | - | - | 100% (580) | oxidoreductase molybdopterin binding subunit |
| M. avium 104 | MAV_1622 | - | 5e-86 | 37.27% (491) | oxidoreductase molybdopterin binding subunit |
| M. avium 104 | MAV_2997 | - | 4e-07 | 26.67% (135) | oxidoreductase, molybdopterin binding |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0224 | - | 2e-07 | 30.66% (137) | transmembrane protein |
| M. gilvum PYR-GCK | Mflv_4320 | - | 1e-05 | 24.44% (180) | oxidoreductase, molybdopterin binding |
| M. tuberculosis H37Rv | Rv0218 | - | 3e-07 | 30.66% (137) | transmembrane protein |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4441 | - | 0.0001 | 26.67% (135) | putative oxidoreductase |
| M. marinum M | MMAR_0461 | - | 1e-06 | 28.47% (137) | hypothetical protein MMAR_0461 |
| M. smegmatis MC2 155 | MSMEG_5334 | - | 9e-35 | 41.80% (189) | hypothetical protein MSMEG_5334 |
| M. thermoresistible (build 8) | - | - | - | - | - |
| M. ulcerans Agy99 | MUL_1110 | - | 2e-06 | 28.47% (137) | hypothetical protein MUL_1110 |
| M. vanbaalenii PYR-1 | Mvan_5892 | - | 4e-11 | 27.22% (158) | oxidoreductase, molybdopterin binding |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_4320|M.gilvum_PYR-GCK -------MTTPGVRAAGGVAAAAVAVGVASLVGAAFGPEADVRTAVGSSV
MAB_4441|M.abscessus_ATCC_1997 -------MEHAARRIIAGLIAAAAALAVGQLAAAAVAPDSAPFYAVGNTV
MAV_2937|M.avium_104 MGTP-----------LTSIPDYRNEIHTAEDVIDVEAYGGGFDLTRRATA
MSMEG_5334|M.smegmatis_MC2_155 MTSAPRIHRTTTVAQLHALLDHHSPRPTFQQRVDVDEFCGGIPQVP-AHA
Mb0224|M.bovis_AF2122/97 ----------------------MSDPARGAEAEDAYGFPAGLWRWLQRHP
Rv0218|M.tuberculosis_H37Rv ----------------------MSDPARGAEAEDAYGFPAGLWRWLQRHP
MMAR_0461|M.marinum_M -----------------MNCPAEDDPERELEPEPAHGFPARLWRTLERHP
MUL_1110|M.ulcerans_Agy99 -----------------MNCPAEDDPERELEPEPAHGFPARLWRTLERHP
Mvan_5892|M.vanbaalenii_PYR-1 -------MDLRGRTHLDPAGPYKRDPPAPHALTERCTSTADLIVLCHFGV
.
Mflv_4320|M.gilvum_PYR-GCK IDLTPGPVKEWAIATFGTADKLALAVMVLLTIAAIAAVAGLAETRRRPVC
MAB_4441|M.abscessus_ATCC_1997 VDHTPAAVREWVIGIFGTSDKAVLFACLTVIIALLAALAGLVEGERR-YG
MAV_2937|M.avium_104 PKLRVGRDRWFNLLWLIPIGFALLIAGVAVGKGLHNMPAVQSFIQRYPGT
MSMEG_5334|M.smegmatis_MC2_155 PSVRIGR-HWVSFAWLAVGALVALAVIVAVAMQLRTYGWVQSFIAHYPGT
Mb0224|M.bovis_AF2122/97 PPA-LHRLTRFRSPLRGPWLTSVFGLVLLVALPFVIITGLLSYIAYAPQL
Rv0218|M.tuberculosis_H37Rv PPA-LHRLTRFRSPLRGPWLTSVFGLVLLVALPFVIITGLLSYIAYAPQL
MMAR_0461|M.marinum_M PPG-VRRLAAFRSPLRGPWLTSVFGLVLLVAMPIVILTGLLSYIAYAPQF
MUL_1110|M.ulcerans_Agy99 PPG-VRRLAAFRSPLRGPWLTSVFGLVLLVAMPIVILTGLLSYIAYAPQF
Mvan_5892|M.vanbaalenii_PYR-1 PRVDRGSWSLRIEGLVHHPTTLTFDELLRYPRTEITAVHQCSGSPFDPAV
: :
Mflv_4320|M.gilvum_PYR-GCK SIAIVIAGGIGCAAVLSRAGSTGADIIPTLIGTACGVAVLRILQSDRLDG
MAB_4441|M.abscessus_ATCC_1997 TVLIGLLGVFGAVAAVTRPAGTFAWIWPSVIAAVAGALVLGTLVHR----
MAV_2937|M.avium_104 DS---AGVPPGLPAWIGWTHFFNLFMMMFIIRTGIQILCDHPRLYFS---
MSMEG_5334|M.smegmatis_MC2_155 SASYAQPVTTGFPAWLRWQHFFNIVFMMFIIRSGLQILADHPRLYLN---
Mb0224|M.bovis_AF2122/97 GQ-----AIPGDVGWLRLPAFTWPTRPSWLYRLTQGLHVGLGLVIIP---
Rv0218|M.tuberculosis_H37Rv GQ-----AIPGDVGWLRLPAFTWPTRPSWLYRLTQGLHVGLGLVIIP---
MMAR_0461|M.marinum_M GQ-----AIPADVGWLRLPGFDWPAHPSWLYRLTQGLHVGLGLVLIP---
MUL_1110|M.ulcerans_Agy99 GQ-----AIPADVGWLRLPGFDWPAHPSWLYRLTQGLHVGLGLVLIP---
Mvan_5892|M.vanbaalenii_PYR-1 PT--------RRVGTATWAGARLADVLADCRPMPQARYIWS---------
.
Mflv_4320|M.gilvum_PYR-GCK PSSETGTDPGRRRSLLTIGLLAAG-------AVSGVAGVVISRLASSVAG
MAB_4441|M.abscessus_ATCC_1997 --AQSQAVPDRRRFFGTAAVFALG-------SAGLYWLGTRWSKGTVVAA
MAV_2937|M.avium_104 ----RNATPGKDEWLRVGPPVPDD--------ELWTANADTVALPPQFGL
MSMEG_5334|M.smegmatis_MC2_155 ----AGCRPG-SEWFRMSHAVPADRTDKSDPPRVWTSKDDAVSLPKWLGI
Mb0224|M.bovis_AF2122/97 ----VVLAKLWSVIPRLFVWPPAR---------SIAQVLERLSVLMLVGG
Rv0218|M.tuberculosis_H37Rv ----VVLAKLWSVIPRLFVWPPAR---------SIAQVLERLSVLMLVGG
MMAR_0461|M.marinum_M ----VVLAKLWSVIPKLFVWPPAR---------SIATLLERLSLLMLVGG
MUL_1110|M.ulcerans_Agy99 ----VVVAKLWSVIPKLFVWPPAR---------SIATLLERLSLLMLVGG
Mvan_5892|M.vanbaalenii_PYR-1 -----------------------------------------------YGA
.
Mflv_4320|M.gilvum_PYR-GCK DRDAFALPRIDTPAAPIPESVQPKGVELPSWVTGNDDFYRIDTALSVPQL
MAB_4441|M.abscessus_ATCC_1997 ERREATVPAPVAPAPPLPEGIDVKGAVP--YITSNTDFYRIDTALRVPQV
MAV_2937|M.avium_104 PGFRHSIGLARWWHLGVDVLWLLNGAVFYVLLFATGQWRHIVPTSWDVFP
MSMEG_5334|M.smegmatis_MC2_155 PGLRHAVGLARL--------------------------------------
Mb0224|M.bovis_AF2122/97 ILFQIVTGVLNIQYDYIFGFSFYTGHYFGAWVFIAGFLLHIVVKIPHMVT
Rv0218|M.tuberculosis_H37Rv ILFQIVTGVLNIQYDYIFGFSFYTGHYFGAWVFIAGFLLHIVVKIPHMVT
MMAR_0461|M.marinum_M VLFEIVTGVLNIQYDYIFGFSFYDGHYFGAWVFIAGFLMHIAVKMPKMIT
MUL_1110|M.ulcerans_Agy99 VLFEIVTGVLNIQYDYIFGFSFYDGHYFGAWVFIAGFLMHIAVKMPKMIT
Mvan_5892|M.vanbaalenii_PYR-1 DGGTFAGAAVDSYCKDLP-------------------LSRVDADVLLCYE
Mflv_4320|M.gilvum_PYR-GCK SRSEWRLRIHGMVDREVTFTYEDLDRFEVVEKVITLTCVSNPVGGELISN
MAB_4441|M.abscessus_ATCC_1997 STAEWQLNIHGMVDRPRTLMWADLNAMAATQRAVTLTCVSNEIGGNLIGN
MAV_2937|M.avium_104 NAASVAVQYLSLDWPTDNGWVAYNGLQLLSYFTTVFIAAPAALITGLGMS
MSMEG_5334|M.smegmatis_MC2_155 --------------------------------------------------
Mb0224|M.bovis_AF2122/97 GLRSIPMREVLGTNVADTRAQPCDPDGLVSVNPGEATLSRRGALGLVGAG
Rv0218|M.tuberculosis_H37Rv GLRSIPMREVLGTNVADTRAQPCDPDGLVSVNPGEATLSRRGALGLVGAG
MMAR_0461|M.marinum_M GLRSFSIREVLRTNVTDTRPEPPDASGLVSEDPAEPTVSRRGALALVGSG
MUL_1110|M.ulcerans_Agy99 GLRSFSIREVLRTNVTNTRPEPPDASGLVSADPAEPTVSRRGALALVGSG
Mvan_5892|M.vanbaalenii_PYR-1 VNGEDLPAEHGFPVR---LLIPGFYGTNSVKWLTTITLADRRAPGPFTAQ
Mflv_4320|M.gilvum_PYR-GCK AVWTG---------------------------------------------
MAB_4441|M.abscessus_ATCC_1997 AVWTG---------------------------------------------
MAV_2937|M.avium_104 PALSQRVHWLSKRLSIQHARSLHFLVLVYFLFFILVHVTMVLTTSALRNL
MSMEG_5334|M.smegmatis_MC2_155 --------------------------------------------------
Mb0224|M.bovis_AF2122/97 VLLIG---------------------------------------------
Rv0218|M.tuberculosis_H37Rv VLLIG---------------------------------------------
MMAR_0461|M.marinum_M VLLLG---------------------------------------------
MUL_1110|M.ulcerans_Agy99 VLLLG---------------------------------------------
Mvan_5892|M.vanbaalenii_PYR-1 WYQDP---------------------------------------------
Mflv_4320|M.gilvum_PYR-GCK ---YRVKDLLAEAGVRSGADMVLSMSVDGWTAGTPVEALT-GDDALLAIG
MAB_4441|M.abscessus_ATCC_1997 ---FPIKPILESVGVHPDADMLLSKSVDGWTAGTPLQVLTDGRDAILAIA
MAV_2937|M.avium_104 NHMFAARDDNSWIGFGIFSAAMVLTAIAWVWATPFTIRHPRVVQRVGYAL
MSMEG_5334|M.smegmatis_MC2_155 --------------------------------------------------
Mb0224|M.bovis_AF2122/97 ----VLTVGQTLGGFTRKAALLLPRGRVVSPG-DFPVNKTAAAAGITAEA
Rv0218|M.tuberculosis_H37Rv ----VLTVGQTLGGFTRKAALLLPRGRVVSPG-DFPVNKTAAAAGITAEA
MMAR_0461|M.marinum_M ----VLTVGQTLGGPLRNIALLLPRGRPAQGNREFPVNKTAAVAGITPEA
MUL_1110|M.ulcerans_Agy99 ----VLTVGQTLGGPLRNIALLLPRGRPAQGNREFPVNKTAAVAGITPEA
Mvan_5892|M.vanbaalenii_PYR-1 -------------------------------------PAAGSEDPHPVWS
Mflv_4320|M.gilvum_PYR-GCK MNGEPLPIEHGYPARLVVPG------------------------------
MAB_4441|M.abscessus_ATCC_1997 MNGTPLPVEHGYPVRQVVPG------------------------------
MAV_2937|M.avium_104 VGPFQRMLEQLDPKPGAFTEKDISPHHWRNGRLPETVEYKELEANDFKDW
MSMEG_5334|M.smegmatis_MC2_155 --------------------------------------------------
Mb0224|M.bovis_AF2122/97 IGPDWRLVLRGGPAEVVLDR------------------------------
Rv0218|M.tuberculosis_H37Rv IGPDWRLVLCGGPAEVVLDR------------------------------
MMAR_0461|M.marinum_M VGPAWRLVLRGGPNEVVLDR------------------------------
MUL_1110|M.ulcerans_Agy99 VGPAWRLVLRGGPNEVVLDR------------------------------
Mvan_5892|M.vanbaalenii_PYR-1 LAPESLIVAP----------------------------------------
Mflv_4320|M.gilvum_PYR-GCK ------LYGYVSATKWVTALELTRFDRAQAYWTRLGWSARGPIKTASRVD
MAB_4441|M.abscessus_ATCC_1997 ------LYGYVSATKWVVDWEITRFDKADAYWTIRGWSARGPIKTGCRID
MAV_2937|M.avium_104 RLKVYGLVEHPMEFSLEDLMALPYHEQISQHFCIQAWSGVAKWGGVQMKT
MSMEG_5334|M.smegmatis_MC2_155 --------------------------------------------------
Mb0224|M.bovis_AF2122/97 ----------------ATLAGLPQRTARLPLACVEGWSAVRTWSGVPLAE
Rv0218|M.tuberculosis_H37Rv ----------------ATLAGLPQRTARLPLACVEGWSAVRTWSGVPLAE
MMAR_0461|M.marinum_M ----------------AALAGLPQHTARLPIACVEGWSTVQTWTGVRLSE
MUL_1110|M.ulcerans_Agy99 ----------------AALAGLPQHTARLPIACVEGWSTVQTWTGVRLSE
Mvan_5892|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_4320|M.gilvum_PYR-GCK VPRSGQDVALGPVTFGGVAWAQNRGVRSVEVQMDDGPWEQATLGDSYSGD
MAB_4441|M.abscessus_ATCC_1997 TPRTGDRLGTGTQIVAGTAWAQHRGIATVEVQIDDGPWLPARLAPEYSVD
MAV_2937|M.avium_104 IMDIVKPLPEAKWAVFYSMGLGATGGIYYNAHHIGQMDHHMTMLAYKMND
MSMEG_5334|M.smegmatis_MC2_155 --------------------------------------------------
Mb0224|M.bovis_AF2122/97 LALLAGVPAARSARVTSLQRGGAFGEAKLAANQIADPD---ALLALRVDG
Rv0218|M.tuberculosis_H37Rv LALLAGVPAARSARVTSLQRGGAFGEAKLAANQIADPD---ALLALRVDG
MMAR_0461|M.marinum_M LARRAGVAAPRSARVTSLQRGGAFGEATLQGNQVGAPD---ALLALRVNG
MUL_1110|M.ulcerans_Agy99 LARRAGVAAPRSARVTSLQRGGAFGEATLQGNQVGASD---ALLALRGNG
Mvan_5892|M.vanbaalenii_PYR-1 ---AAGQSLHRDAEVAIWGWAWADGGVSQVDVGIGGSWHAAEVEGCR-GW
Mflv_4320|M.gilvum_PYR-GCK TWRMWSYAWEARDTGFHTITVRATDDSGYTQTPDRADPVPDGATGWHSIT
MAB_4441|M.abscessus_ATCC_1997 TWRQWWFAWQA-TAGEHIITARATDGTGAVQTDQIASPVPDGATGYPKRL
MAV_2937|M.avium_104 QQLPYMHGRPLRLRNELQHGFKLVKWIKGIEFVADYRDIGSGYGGYSEDH
MSMEG_5334|M.smegmatis_MC2_155 --------------------------------------------------
Mb0224|M.bovis_AF2122/97 ADLSLNHGYPARIIVPALPGVHNTKWVAGIEFHKR---------------
Rv0218|M.tuberculosis_H37Rv ADLSLDHGYPARIIVPALPGVHNTKWVAGIEFHKR---------------
MMAR_0461|M.marinum_M EDLPLDHGYPARIIVPALPGVHNTKWVASINFEAG---------------
MUL_1110|M.ulcerans_Agy99 EDLPLDHGYPARIIVPALPGVHNTKWVASINFEAG---------------
Mvan_5892|M.vanbaalenii_PYR-1 QWQRFSTAWTPSQPGTVEVAARATSSLGQVQPTSGHRNAVHSVMVDVRDE
Mflv_4320|M.gilvum_PYR-GCK FAVK-----
MAB_4441|M.abscessus_ATCC_1997 VTVAA----
MAV_2937|M.avium_104 KYFGRHQTL
MSMEG_5334|M.smegmatis_MC2_155 ---------
Mb0224|M.bovis_AF2122/97 ---------
Rv0218|M.tuberculosis_H37Rv ---------
MMAR_0461|M.marinum_M ---------
MUL_1110|M.ulcerans_Agy99 ---------
Mvan_5892|M.vanbaalenii_PYR-1 EPWT-----