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ADATVPNALVCLCGGTFALAESGASRVAGMAGPSANERMLAGVAAASVALGVAQVVSIPFGTRADARTAV GSAVIDITPGPIKEWAIQALGPLDKPFLAIVVLVVIATLAALAGTLETQRRPLGSAVIAAAGVLGCAAVL SRQGGTLLDTIPTIAGAACGVLLLRVLMRRFWPDAEDPNGSGDQSDAGRRRLVMLGLLGFGVVTGVTGAV LVRLAHSVAADRKAFTLPQPGTTAPPIPADVKPKGVALPDFITPSADFYRINTALVVPQLSRGDWRLRIH GMVDREISYTFDDLTQFDVVETVATLTCVSNPVGGNLISTGIWTGYRIADLLSAAGVHKDADMVLSTSID GFTAGTPVQTLTDGREALLALGLNGQPLPVEHGYPARLVVPGLYGYVSATKWVVELELTRFDRAKAYWTR QGWAARAPIKTESRIDVPKRGQKVPVGPVVFGGVAWAQNRGVRAVEVRIGDGGWQRAELGASYSNATWRL WSLPWQAKSPGTHTITVRAIDNTGAVQTEDRADPVPDGATGWHTVTFTVVDK*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_2279 | - | - | 100% (543) | membrane-bound oxidoreductase |
| M. ulcerans Agy99 | MUL_1110 | - | 6e-10 | 40.70% (86) | hypothetical protein MUL_1110 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1786 | - | 1e-29 | 32.57% (350) | sulfite oxidase |
| M. gilvum PYR-GCK | Mflv_4320 | - | 0.0 | 64.61% (503) | oxidoreductase, molybdopterin binding |
| M. tuberculosis H37Rv | Rv0218 | - | 3e-08 | 28.57% (238) | transmembrane protein |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4441 | - | 1e-127 | 47.95% (511) | putative oxidoreductase |
| M. marinum M | MMAR_3039 | - | 0.0 | 98.44% (513) | membrane-bound oxidoreductase |
| M. avium 104 | MAV_2997 | - | 9e-11 | 44.83% (87) | oxidoreductase, molybdopterin binding |
| M. smegmatis MC2 155 | MSMEG_2278 | - | 0.0 | 64.55% (519) | membrane-bound oxidoreductase |
| M. thermoresistible (build 8) | - | - | - | - | - |
| M. vanbaalenii PYR-1 | Mvan_2026 | - | 0.0 | 66.02% (512) | oxidoreductase, molybdopterin binding |
CLUSTAL 2.0.9 multiple sequence alignment
MUL_2279|M.ulcerans_Agy99 MADATVPNALVCLCGGTFALAESGASRVAGMAGPSANERMLAGVAAASVA
MMAR_3039|M.marinum_M ------------------------------MAGPSANERMLAGVAAASVA
Mflv_4320|M.gilvum_PYR-GCK --------------------------------MTTPGVRAAGGVAAAAVA
Mvan_2026|M.vanbaalenii_PYR-1 --------------------------------MTTPGAKAMTGVAAAAVA
MSMEG_2278|M.smegmatis_MC2_155 ------------------------------MSERVRRTPPLAGLAAAAVA
MAB_4441|M.abscessus_ATCC_1997 --------------------------------MEHAARRIIAGLIAAAAA
Rv0218|M.tuberculosis_H37Rv ----------------------------------------MSDPARGAEA
MAV_2997|M.avium_104 -----------------------------------------MKPTR----
Mb1786|M.bovis_AF2122/97 --------------------------------------------------
MUL_2279|M.ulcerans_Agy99 LGVAQVVSIPFGTRADARTAVGSAVIDITPGPIKEWAIQALGPLDKPFLA
MMAR_3039|M.marinum_M LGVAQVVSIPFGTRADARTAVGSAVIDITPGPIKEWAIQALGPLDKPFLA
Mflv_4320|M.gilvum_PYR-GCK VGVASLVGAAFGPEADVRTAVGSSVIDLTPGPVKEWAIATFGTADKLALA
Mvan_2026|M.vanbaalenii_PYR-1 VGVAQLVGAAFGPQADVRTAVGSAVIELTPGAVKEWAIDTFGTADKLALT
MSMEG_2278|M.smegmatis_MC2_155 LGVAGIVAVPFGPAADSRTAVGSAVIDLTPGPVKEWAITTFGTADKLLLT
MAB_4441|M.abscessus_ATCC_1997 LAVGQLAAAAVAPDSAPFYAVGNTVVDHTPAAVREWVIGIFGTSDKAVLF
Rv0218|M.tuberculosis_H37Rv EDAYGFPAGLWRWLQRHPPPALHRLTRFRSPLRGPWLTSVFGLVLLVALP
MAV_2997|M.avium_104 TTGRSFPERLWR-----------------SPLRGPWLTSVFGSILLVTLP
Mb1786|M.bovis_AF2122/97 ---------------------------MTDRGENRTTIAMLETAGLWGKR
:
MUL_2279|M.ulcerans_Agy99 IVVLVVIATLAALAGTLETQRRPLGSAVIAAAGVLGCAAVLSRQGGTLLD
MMAR_3039|M.marinum_M IVVLVVIATLAALAGTLETQRRPLGSAVIAAAGVLGCAAVLSRQGGTLLD
Mflv_4320|M.gilvum_PYR-GCK VMVLLTIAAIAAVAGLAETRRRPVCSIAIVIAGGIGCAAVLSRAGSTGAD
Mvan_2026|M.vanbaalenii_PYR-1 VMVLAVIAVIAAVAGILESRRRPIGSTAIVAAGGVGCAAVLSRAGATLVD
MSMEG_2278|M.smegmatis_MC2_155 VLIIAIIATLAAVTAPLETRRRPVGSIVIGLAGVLGCVAVLSRPGAGWVA
MAB_4441|M.abscessus_ATCC_1997 ACLTVIIALLAALAGLVEGERR-YGTVLIGLLGVFGAVAAVTRPAGTFAW
Rv0218|M.tuberculosis_H37Rv FVIITGLLSYIAYA-------PQLGQAIPGDVGWLRLPAFTWPTRPSWLY
MAV_2997|M.avium_104 VVIVTGLLSYIAYG-------PRFGQAVPAEVGWLRLPVFDWPTDPSWLY
Mb1786|M.bovis_AF2122/97 ADMIVRGCLPYNAE---------PPPAVLAGSDITPINAFYVRNHGPVPD
: . .
MUL_2279|M.ulcerans_Agy99 TIPTIAGAACGVLLLRVLMRRFWPDAED--------------PNGSGDQS
MMAR_3039|M.marinum_M TIPTIAGAACGVLLLRVLMRRFWPDAED--------------PNGSGDKS
Mflv_4320|M.gilvum_PYR-GCK IIPTLIGTACGVAVLRILQSDRLDGP------------------SSETGT
Mvan_2026|M.vanbaalenii_PYR-1 IVPTLVGTACGVAVLRLLVSGRFTDE------------------GEEAST
MSMEG_2278|M.smegmatis_MC2_155 ILPTVIGAVCGIAALRLLTSDRFRDEQAVAEDRADQRADRYADDHADDTV
MAB_4441|M.abscessus_ATCC_1997 IWPSVIAAVAGALVLGTLVHR------------------------AQSQA
Rv0218|M.tuberculosis_H37Rv RLTQGLHVGLGLVIIPVVLAKLWS----------------------VIPR
MAV_2997|M.avium_104 RATQGLHVGLGLVLIPVVLAKLWS----------------------VIPR
Mb1786|M.bovis_AF2122/97 IAPQHWRLTVGGLVDNPLTVTYER--------------------------
. * :
MUL_2279|M.ulcerans_Agy99 DAGRRR-LVMLGLLGFGVVTGVTGAVLVRLAHSVAADRKAFTLPQPGTTA
MMAR_3039|M.marinum_M DAGRRR-LIMLGLLGFGVVTGVTGAVLARLAHSVAADRKAFTLPQPGTTA
Mflv_4320|M.gilvum_PYR-GCK DPGRRRSLLTIGLLAAGAVSGVAGVVISRLASSVAGDRDAFALPRIDTPA
Mvan_2026|M.vanbaalenii_PYR-1 DQGRRLSLVTLGLLGAGVASGALGVVITRLASSVSGDREAFALPKVNKAA
MSMEG_2278|M.smegmatis_MC2_155 DPGRRWSLVALGLLTTGVVTGAAGAVLSRLASSVAGDRDAFTLPRAARAA
MAB_4441|M.abscessus_ATCC_1997 VPDRRRFFGTAAVFALGSAGLYWLGTRWSKGTVVAAERREATVPAPVAPA
Rv0218|M.tuberculosis_H37Rv LFVWPPARSIAQVLERLSVLMLVGGILFQIVTGVLNIQYDYIFGFSFYTG
MAV_2997|M.avium_104 LFAWPPARSIAQLLERVSVLMLVGGILFEMVTGVLNIQYDYIFGFSFYTA
Mb1786|M.bovis_AF2122/97 -------------LTTEFDQHCVVATLACAGNRRAELLRVRQIPGKEPWA
: . .
MUL_2279|M.ulcerans_Agy99 PPIPADVKPKGVALPDFITPSADFYRINTALVVPQLSRGDWRLRIHGMVD
MMAR_3039|M.marinum_M PPIPADVQPKGVALPDFITPSADFYRIDTALVVPQLSRGDWRLRIHGMVD
Mflv_4320|M.gilvum_PYR-GCK APIPESVQPKGVELPSWVTGNDDFYRIDTALSVPQLSRSEWRLRIHGMVD
Mvan_2026|M.vanbaalenii_PYR-1 APIPDGVQPKGVALPSFVTSNSDFYRIDTALSVPQLSRQDWRLRIHGMVD
MSMEG_2278|M.smegmatis_MC2_155 APIPPDVQPAGVSLPSFITPTPKFYRIDTALTVPQLTRDEWQLRIHGMTD
MAB_4441|M.abscessus_ATCC_1997 PPLPEGIDVKGAVP--YITSNTDFYRIDTALRVPQVSTAEWQLNIHGMVD
Rv0218|M.tuberculosis_H37Rv HYFGAWVFIAGFLLHIVVKIPHMVTGLRSIPMREVLGTN-------VADT
MAV_2997|M.avium_104 HYFGAWVFVIGFLMHVTIKGRRMWAGLRSMSMRAVLRTP-------AADT
Mb1786|M.bovis_AF2122/97 HGAISTAQWCGVRLADILQAAD------------------------VHID
* :
MUL_2279|M.ulcerans_Agy99 REISYTFDDLTQFDVVETVATLTCVSNPVGGNLISTGIWTGYRIADLLSA
MMAR_3039|M.marinum_M REISYTFDDLTQFDVVETVATLTCVSNPVGGNLISTGIWTGYRVADLLSA
Mflv_4320|M.gilvum_PYR-GCK REVTFTYEDLDRFEVVEKVITLTCVSNPVGGELISNAVWTGYRVKDLLAE
Mvan_2026|M.vanbaalenii_PYR-1 REVTYRYEDLSRFEVVEKVVTLTCVSNPVGGELISNAVWTGYRVGDLLAE
MSMEG_2278|M.smegmatis_MC2_155 REVTYRFEDLDRFEVVEKVVTLTCVSNFVGGDLISNATWTGYRVRDLLEE
MAB_4441|M.abscessus_ATCC_1997 RPRTLMWADLNAMAATQRAVTLTCVSNEIGGNLIGNAVWTGFPIKPILES
Rv0218|M.tuberculosis_H37Rv RAQPCDPDGLVSVNPGEATLSRRGALGLVGAGVLLIGVLTVG-----QTL
MAV_2997|M.avium_104 EPEPWRPGGLAAAEPGPATMSRRGALALVGGGALFLALITAG-----QTL
Mb1786|M.bovis_AF2122/97 EGLHVAFDAPDVAEEARPIQPYG---------------------------
. .
MUL_2279|M.ulcerans_Agy99 AGVHKDADMVLSTSIDGFTAGTPVQTLTDGREALLALGLNGQPLPVEHGY
MMAR_3039|M.marinum_M AGVHKDADMVLSTSIDGFTAGTPVQALTDGREALLALGLNGQPLPVEHGY
Mflv_4320|M.gilvum_PYR-GCK AGVRSGADMVLSMSVDGWTAGTPVEALTGD-DALLAIGMNGEPLPIEHGY
Mvan_2026|M.vanbaalenii_PYR-1 AGVQPDADMVLSMSVDGWSAGTPVEALTDG-DALLAIGMNGEPLPIEHGY
MSMEG_2278|M.smegmatis_MC2_155 AGVSTDSDMALSTSIDGFTAGSPIEALTDDRDALLAIGMNGEPLPAAHGY
MAB_4441|M.abscessus_ATCC_1997 VGVHPDADMLLSKSVDGWTAGTPLQVLTDGRDAILAIAMNGTPLPVEHGY
Rv0218|M.tuberculosis_H37Rv GGFTRKAALLLP--RGRVVSPGDFPVNKTAAAAGITAEAIGPDWRLVLCG
MAV_2997|M.avium_104 GGRTRPAALLLPHGRGRGSGANDFDVNRTAAAAGIAAADIGARWRLTLGG
Mb1786|M.bovis_AF2122/97 SSIPLSKALSPEVLLAWQMNSEPLPRAHGGPVRVVVPGFIG-----ARSV
. : . :. *
MUL_2279|M.ulcerans_Agy99 PARLVVPGLYGYVSATKWVVELELTRFDRAKAYWTRQGWAARAPIKTESR
MMAR_3039|M.marinum_M PARLVVPGLYGYVSATKWVVELELTRFDRAKAYWTRQGWAARAPIKTESR
Mflv_4320|M.gilvum_PYR-GCK PARLVVPGLYGYVSATKWVTALELTRFDRAQAYWTRLGWSARGPIKTASR
Mvan_2026|M.vanbaalenii_PYR-1 PARLVVPGLYGYVSATKWVTDLELTRFDRAEAYWTRLGWSARGPIKTESR
MSMEG_2278|M.smegmatis_MC2_155 PARLVVPGLYGYVSATKWVVDLELTRFDRAEAYWTKLGWSAHGPIKTQSR
MAB_4441|M.abscessus_ATCC_1997 PVRQVVPGLYGYVSATKWVVDWEITRFDKADAYWTIRGWSARGPIKTGCR
Rv0218|M.tuberculosis_H37Rv GPAEVVLDRATLAGLPQRTARLPLA---CVEGWSAVRTWSGVPLAELALL
MAV_2997|M.avium_104 GARPVVLDRASLLAMPQHTAVLPIA---CVEGWSTTQAWTGVRLADLARL
Mb1786|M.bovis_AF2122/97 KWVTAITVQPGASQNYFQALDYRILPADADADIVGPGEGISLSSLALNCD
.: . : .
MUL_2279|M.ulcerans_Agy99 IDVPKRGQKVPVGPVVFGGVAWAQN-RGVRAVEVRIGD----GGWQRAEL
MMAR_3039|M.marinum_M IDVPRRGQKVPVGPVVFGGVAWAQN-RGVRAVEVRIGD----GGWQRAEL
Mflv_4320|M.gilvum_PYR-GCK VDVPRSGQDVALGPVTFGGVAWAQN-RGVRSVEVQMDD----GPWEQATL
Mvan_2026|M.vanbaalenii_PYR-1 IDVPRSGQDVPVGPVTFGGVAWAQD-RGIRAVEVQIDD----GDWRQATL
MSMEG_2278|M.smegmatis_MC2_155 IDVPREGQQVPRGPVRFGGVAWAQH-RGIRAVEVKIDGPSDPGEWQQAQL
MAB_4441|M.abscessus_ATCC_1997 IDTPRTGDRLGTGTQIVAGTAWAQH-RGIATVEVQIDD----GPWLPARL
Rv0218|M.tuberculosis_H37Rv AGVPAARSARVTSLQRGGAFGEAKL-AANQIADP-------------DAL
MAV_2997|M.avium_104 AGVPAPRSARVSSVERVGAFNAATL-HGSQVLHP-------------DAL
Mb1786|M.bovis_AF2122/97 ILDPTDGDDVPAGALTIRGYGMAGDGRSVERVDVSVDDG---LTWQQADL
* . . . * . . *
MUL_2279|M.ulcerans_Agy99 GASYSNATWRLWSLPWQAKSPGTHTITVRAIDNTGAVQTEDRA---DPVP
MMAR_3039|M.marinum_M GASYSNATWRLWSLPWQAKSPGTHTITVRAIDNTGAVQTEDRA---DPVP
Mflv_4320|M.gilvum_PYR-GCK GDSYSGDTWRMWSYAWEARDTGFHTITVRATDDSGYTQTPDRA---DPVP
Mvan_2026|M.vanbaalenii_PYR-1 GDAYSGDTWRLWSFPWDARETGFHTITVRATDNDGYTQTPDRA---DPVP
MSMEG_2278|M.smegmatis_MC2_155 GAAYSDDTWRLWSVDWTAADPGEHTITVRATDNTGETQTPDLA---DPVP
MAB_4441|M.abscessus_ATCC_1997 APEYSVDTWRQWWFAWQAT-AGEHIITARATDGTGAVQTDQIA---SPVP
Rv0218|M.tuberculosis_H37Rv LALRVDGADLSLDHGYPARIIVPALPGVHNTKWVAGIEFHKR--------
MAV_2997|M.avium_104 LALRVNGAELSVDHGFPARIVVPALPGVHNTKWVGAIDFRAGS---DA--
Mb1786|M.bovis_AF2122/97 HAAPSQWSWRPWSLTVDVE-PGPLGITARAWDDTGALQPESAVSLWNPRG
: . .: . . :
MUL_2279|M.ulcerans_Agy99 DGATGWHTVTFTVVDK
MMAR_3039|M.marinum_M DGATGWHTVTFTVVDK
Mflv_4320|M.gilvum_PYR-GCK DGATGWHSITFAVK--
Mvan_2026|M.vanbaalenii_PYR-1 DGATGWHSITFAVR--
MSMEG_2278|M.smegmatis_MC2_155 DGATGWHYVTFDVT--
MAB_4441|M.abscessus_ATCC_1997 DGATGYPKRLVTVAA-
Rv0218|M.tuberculosis_H37Rv ----------------
MAV_2997|M.avium_104 ----------------
Mb1786|M.bovis_AF2122/97 YGNNAWARVALRVS--