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LTDRGENRTTIAMLETAGLWGKRADMIVRGCLPYNAEPPPAVLAGSDITPINAFYVRNHGPVPDIAPQHW RLTVGGLVDNPLTVTYERLTTEFDQHCVVATLACAGNRRAELLRVRQIPGKEPWAHGAISTAQWCGVRLA DILQAADVHIDEGLHVAFDAPDVAEEARPIQPYGSSIPLSKALSPEVLLAWQMNSEPLPRAHGGPVRVVV PGFIGARSVKWVTAITVQPGASQNYFQALDYRILPADADADIVGPGEGISLSSLALNCDILDPTDGDDVP AGALTIRGYGMAGDGRSVERVDVSVDDGLTWQQADLHAAPSQWSWRPWSLTVDVEPGPLGITARAWDDTG ALQPESAVSLWNPRGYGNNAWARVALRVS
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1786 | - | - | 100% (379) | sulfite oxidase |
| M. bovis AF2122 / 97 | Mb0224 | - | 5e-05 | 28.03% (157) | transmembrane protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_4320 | - | 1e-25 | 30.72% (345) | oxidoreductase, molybdopterin binding |
| M. tuberculosis H37Rv | Rv0218 | - | 7e-05 | 28.03% (157) | transmembrane protein |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4441 | - | 3e-20 | 28.61% (339) | putative oxidoreductase |
| M. marinum M | MMAR_3039 | - | 3e-29 | 32.29% (350) | membrane-bound oxidoreductase |
| M. avium 104 | MAV_2997 | - | 1e-10 | 31.48% (162) | oxidoreductase, molybdopterin binding |
| M. smegmatis MC2 155 | MSMEG_2278 | - | 4e-24 | 29.80% (349) | membrane-bound oxidoreductase |
| M. thermoresistible (build 8) | - | - | - | - | - |
| M. ulcerans Agy99 | MUL_2279 | - | 8e-30 | 32.57% (350) | membrane-bound oxidoreductase |
| M. vanbaalenii PYR-1 | Mvan_5892 | - | 3e-28 | 29.14% (326) | oxidoreductase, molybdopterin binding |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_4320|M.gilvum_PYR-GCK ------------------------------MTTPGVR--AAGGVAAAAVA
MSMEG_2278|M.smegmatis_MC2_155 ------------------------------MSERVRRTPPLAGLAAAAVA
MMAR_3039|M.marinum_M ------------------------------MAGPSANERMLAGVAAASVA
MUL_2279|M.ulcerans_Agy99 MADATVPNALVCLCGGTFALAESGASRVAGMAGPSANERMLAGVAAASVA
MAB_4441|M.abscessus_ATCC_1997 ------------------------------MEHAARR--IIAGLIAAAAA
Rv0218|M.tuberculosis_H37Rv ----------------------------------------MSDPARGAEA
MAV_2997|M.avium_104 -----------------------------------------MKPTR----
Mb1786|M.bovis_AF2122/97 --------------------------------------------------
Mvan_5892|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_4320|M.gilvum_PYR-GCK VGVASLVGAAFGPEADVRTAVGSSVIDLTPGPVKEWAIATFGTADKLALA
MSMEG_2278|M.smegmatis_MC2_155 LGVAGIVAVPFGPAADSRTAVGSAVIDLTPGPVKEWAITTFGTADKLLLT
MMAR_3039|M.marinum_M LGVAQVVSIPFGTRADARTAVGSAVIDITPGPIKEWAIQALGPLDKPFLA
MUL_2279|M.ulcerans_Agy99 LGVAQVVSIPFGTRADARTAVGSAVIDITPGPIKEWAIQALGPLDKPFLA
MAB_4441|M.abscessus_ATCC_1997 LAVGQLAAAAVAPDSAPFYAVGNTVVDHTPAAVREWVIGIFGTSDKAVLF
Rv0218|M.tuberculosis_H37Rv EDAYGFPAGLWRWLQRHPPPALHRLTRFRSPLRGPWLTSVFGLVLLVALP
MAV_2997|M.avium_104 TTGRSFPERLWR-----------------SPLRGPWLTSVFGSILLVTLP
Mb1786|M.bovis_AF2122/97 ---------------------------MTDRGENRTTIAMLETAGLWGKR
Mvan_5892|M.vanbaalenii_PYR-1 ----------------------------------------------MDLR
Mflv_4320|M.gilvum_PYR-GCK VMVLLTIAAIAAVAGLAETRRRPVCSIAIVIAGGIGCAAVLSRAGSTGAD
MSMEG_2278|M.smegmatis_MC2_155 VLIIAIIATLAAVTAPLETRRRPVGSIVIGLAGVLGCVAVLSRPGAGWVA
MMAR_3039|M.marinum_M IVVLVVIATLAALAGTLETQRRPLGSAVIAAAGVLGCAAVLSRQGGTLLD
MUL_2279|M.ulcerans_Agy99 IVVLVVIATLAALAGTLETQRRPLGSAVIAAAGVLGCAAVLSRQGGTLLD
MAB_4441|M.abscessus_ATCC_1997 ACLTVIIALLAALAGLVEGERR-YGTVLIGLLGVFGAVAAVTRPAGTFAW
Rv0218|M.tuberculosis_H37Rv FVIITGLLSYIAYA-------PQLGQAIPGDVGWLRLPAFTWPTRPSWLY
MAV_2997|M.avium_104 VVIVTGLLSYIAYG-------PRFGQAVPAEVGWLRLPVFDWPTDPSWLY
Mb1786|M.bovis_AF2122/97 ADMIVRGCLPYNAE---------PPPAVLAGSDITPINAFYVRNHGPVPD
Mvan_5892|M.vanbaalenii_PYR-1 GRTHLDPAGPYKRD-------PPAPHALTERCTSTADLIVLCHFGVPRVD
Mflv_4320|M.gilvum_PYR-GCK IIPTLIGTACGVAVLRILQSDRLDGP------------------SSETGT
MSMEG_2278|M.smegmatis_MC2_155 ILPTVIGAVCGIAALRLLTSDRFRDEQAVAEDRADQRADRYADDHADDTV
MMAR_3039|M.marinum_M TIPTIAGAACGVLLLRVLMRRFWPDAED--------------PNGSGDKS
MUL_2279|M.ulcerans_Agy99 TIPTIAGAACGVLLLRVLMRRFWPDAED--------------PNGSGDQS
MAB_4441|M.abscessus_ATCC_1997 IWPSVIAAVAGALVLGTLVHR------------------------AQSQA
Rv0218|M.tuberculosis_H37Rv RLTQGLHVGLGLVIIPVVLAKLWSVIPR-------------------LFV
MAV_2997|M.avium_104 RATQGLHVGLGLVLIPVVLAKLWSVIPR-------------------LFA
Mb1786|M.bovis_AF2122/97 IAPQHWRLTVGGLVDNPLTVT-----------------------------
Mvan_5892|M.vanbaalenii_PYR-1 RGSWSLRIEG----------------------------------------
.
Mflv_4320|M.gilvum_PYR-GCK DPGRRRSLLTIGLLAAGAVSGVAGVVISRLASSVAGDRDAFALPRIDTPA
MSMEG_2278|M.smegmatis_MC2_155 DPGRRWSLVALGLLTTGVVTGAAGAVLSRLASSVAGDRDAFTLPRAARAA
MMAR_3039|M.marinum_M DAGRRR-LIMLGLLGFGVVTGVTGAVLARLAHSVAADRKAFTLPQPGTTA
MUL_2279|M.ulcerans_Agy99 DAGRRR-LVMLGLLGFGVVTGVTGAVLVRLAHSVAADRKAFTLPQPGTTA
MAB_4441|M.abscessus_ATCC_1997 VPDRRRFFGTAAVFALGSAGLYWLGTRWSKGTVVAAERREATVPAPVAPA
Rv0218|M.tuberculosis_H37Rv WPPARS---IAQVLERLSVLMLVGGILFQIVTGVLNIQYDYIFGFSFYTG
MAV_2997|M.avium_104 WPPARS---IAQLLERVSVLMLVGGILFEMVTGVLNIQYDYIFGFSFYTA
Mb1786|M.bovis_AF2122/97 ----------YERLTTEFDQHCVVATLACAGNRRAELLRVRQIPGKEPWA
Mvan_5892|M.vanbaalenii_PYR-1 -------------LVHHPTTLTFDELLRYPRTEITAVHQCSGSPFDPAVP
:
Mflv_4320|M.gilvum_PYR-GCK APIPESVQPKGVELPSWVTGNDDFYRIDTALSVPQLSRSEWRLRIHGMVD
MSMEG_2278|M.smegmatis_MC2_155 APIPPDVQPAGVSLPSFITPTPKFYRIDTALTVPQLTRDEWQLRIHGMTD
MMAR_3039|M.marinum_M PPIPADVQPKGVALPDFITPSADFYRIDTALVVPQLSRGDWRLRIHGMVD
MUL_2279|M.ulcerans_Agy99 PPIPADVKPKGVALPDFITPSADFYRINTALVVPQLSRGDWRLRIHGMVD
MAB_4441|M.abscessus_ATCC_1997 PPLPEGIDVKGAVP--YITSNTDFYRIDTALRVPQVSTAEWQLNIHGMVD
Rv0218|M.tuberculosis_H37Rv HYFGAWVFIAGFLLHIVVKIPHMVTGLRSIPMREVLGTN-------VADT
MAV_2997|M.avium_104 HYFGAWVFVIGFLMHVTIKGRRMWAGLRSMSMRAVLRTP-------AADT
Mb1786|M.bovis_AF2122/97 HGAISTAQWCGVRLADILQAAD------------------------VHID
Mvan_5892|M.vanbaalenii_PYR-1 TRRVGTATWAGARLADVLADCR------------------------PMPQ
* :
Mflv_4320|M.gilvum_PYR-GCK REVTFTYEDLDRFEVVEKVITLTCVSNPVGGELISNAVWTGYRVKDLLAE
MSMEG_2278|M.smegmatis_MC2_155 REVTYRFEDLDRFEVVEKVVTLTCVSNFVGGDLISNATWTGYRVRDLLEE
MMAR_3039|M.marinum_M REISYTFDDLTQFDVVETVATLTCVSNPVGGNLISTGIWTGYRVADLLSA
MUL_2279|M.ulcerans_Agy99 REISYTFDDLTQFDVVETVATLTCVSNPVGGNLISTGIWTGYRIADLLSA
MAB_4441|M.abscessus_ATCC_1997 RPRTLMWADLNAMAATQRAVTLTCVSNEIGGNLIGNAVWTGFPIKPILES
Rv0218|M.tuberculosis_H37Rv RAQPCDPDGLVSVNPGEATLSRRGALGLVGAGVLLIGVLTVG-----QTL
MAV_2997|M.avium_104 EPEPWRPGGLAAAEPGPATMSRRGALALVGGGALFLALITAG-----QTL
Mb1786|M.bovis_AF2122/97 EGLHVAFDAPDVAEEARPIQPYG---------------------------
Mvan_5892|M.vanbaalenii_PYR-1 ARYIWSYG------------------------------------------
Mflv_4320|M.gilvum_PYR-GCK AGVRSGADMVLSMSVDGWTAGTPVEALTGD-DALLAIGMNGEPLPIEHGY
MSMEG_2278|M.smegmatis_MC2_155 AGVSTDSDMALSTSIDGFTAGSPIEALTDDRDALLAIGMNGEPLPAAHGY
MMAR_3039|M.marinum_M AGVHKDADMVLSTSIDGFTAGTPVQALTDGREALLALGLNGQPLPVEHGY
MUL_2279|M.ulcerans_Agy99 AGVHKDADMVLSTSIDGFTAGTPVQTLTDGREALLALGLNGQPLPVEHGY
MAB_4441|M.abscessus_ATCC_1997 VGVHPDADMLLSKSVDGWTAGTPLQVLTDGRDAILAIAMNGTPLPVEHGY
Rv0218|M.tuberculosis_H37Rv GGFTRKAALLLP--RGRVVSPGDFPVNKTAAAAGITAEAIGPDWRLVLCG
MAV_2997|M.avium_104 GGRTRPAALLLPHGRGRGSGANDFDVNRTAAAAGIAAADIGARWRLTLGG
Mb1786|M.bovis_AF2122/97 SSIPLSKALSPEVLLAWQMNSEPLPRAHGGPVRVVVPGFIG-----ARSV
Mvan_5892|M.vanbaalenii_PYR-1 ----ADGGTFAGAAVDSYCKDLPLSR--VDADVLLCYEVNGEDLPAEHGF
. : *
Mflv_4320|M.gilvum_PYR-GCK PARLVVPGLYGYVSATKWVTALELTRFDRAQAYWTRLGWSARGP------
MSMEG_2278|M.smegmatis_MC2_155 PARLVVPGLYGYVSATKWVVDLELTRFDRAEAYWTKLGWSAHGP------
MMAR_3039|M.marinum_M PARLVVPGLYGYVSATKWVVELELTRFDRAKAYWTRQGWAARAP------
MUL_2279|M.ulcerans_Agy99 PARLVVPGLYGYVSATKWVVELELTRFDRAKAYWTRQGWAARAP------
MAB_4441|M.abscessus_ATCC_1997 PVRQVVPGLYGYVSATKWVVDWEITRFDKADAYWTIRGWSARGP------
Rv0218|M.tuberculosis_H37Rv GPAEVVLDRATLAGLPQRTARLPLA---CVEGWSAVRTWSGVPL------
MAV_2997|M.avium_104 GARPVVLDRASLLAMPQHTAVLPIA---CVEGWSTTQAWTGVRL------
Mb1786|M.bovis_AF2122/97 KWVTAITVQPGASQNYFQALDYRILPADADADIVGPGEGISLSS------
Mvan_5892|M.vanbaalenii_PYR-1 PVRLLIPGFYG-TNSVKWLTTITLADRRAPGPFTAQWYQDPPAAGSEDPH
: :
Mflv_4320|M.gilvum_PYR-GCK ----IKTASRVDVPRSGQDVA-LGPVTFGGVAWAQN-RGVRSVEVQMDD-
MSMEG_2278|M.smegmatis_MC2_155 ----IKTQSRIDVPREGQQVP-RGPVRFGGVAWAQH-RGIRAVEVKIDGP
MMAR_3039|M.marinum_M ----IKTESRIDVPRRGQKVP-VGPVVFGGVAWAQN-RGVRAVEVRIGD-
MUL_2279|M.ulcerans_Agy99 ----IKTESRIDVPKRGQKVP-VGPVVFGGVAWAQN-RGVRAVEVRIGD-
MAB_4441|M.abscessus_ATCC_1997 ----IKTGCRIDTPRTGDRLG-TGTQIVAGTAWAQH-RGIATVEVQIDD-
Rv0218|M.tuberculosis_H37Rv ----AELALLAGVPAARSARV-TSLQRGGAFGEAKL-AANQIADP-----
MAV_2997|M.avium_104 ----ADLARLAGVPAPRSARV-SSVERVGAFNAATL-HGSQVLHP-----
Mb1786|M.bovis_AF2122/97 ----LALNCDILDPTDGDDVP-AGALTIRGYGMAGDGRSVERVDVSVDDG
Mvan_5892|M.vanbaalenii_PYR-1 PVWSLAPESLIVAPAAGQSLHRDAEVAIWGWAWADG--GVSQVDVGIGG-
* . . . * . .
Mflv_4320|M.gilvum_PYR-GCK ---GPWEQATLGDSYSGDTWRMWSYAWEARDTGFHTITVRATDDSGYTQT
MSMEG_2278|M.smegmatis_MC2_155 SDPGEWQQAQLGAAYSDDTWRLWSVDWTAADPGEHTITVRATDNTGETQT
MMAR_3039|M.marinum_M ---GGWQRAELGASYSNATWRLWSLPWQAKSPGTHTITVRAIDNTGAVQT
MUL_2279|M.ulcerans_Agy99 ---GGWQRAELGASYSNATWRLWSLPWQAKSPGTHTITVRAIDNTGAVQT
MAB_4441|M.abscessus_ATCC_1997 ---GPWLPARLAPEYSVDTWRQWWFAWQAT-AGEHIITARATDGTGAVQT
Rv0218|M.tuberculosis_H37Rv --------DALLALRVDGADLSLDHGYPARIIVPALPGVHNTKWVAGIEF
MAV_2997|M.avium_104 --------DALLALRVNGAELSVDHGFPARIVVPALPGVHNTKWVGAIDF
Mb1786|M.bovis_AF2122/97 ---LTWQQADLHAAPSQWSWRPWSLTVDVE-PGPLGITARAWDDTGALQP
Mvan_5892|M.vanbaalenii_PYR-1 ----SWHAAEVEGCRG-WQWQRFSTAWTPSQPGTVEVAARATSSLGQVQP
: .: . . :
Mflv_4320|M.gilvum_PYR-GCK PDRA---DPVPDGATGWHSITFAVK--
MSMEG_2278|M.smegmatis_MC2_155 PDLA---DPVPDGATGWHYVTFDVT--
MMAR_3039|M.marinum_M EDRA---DPVPDGATGWHTVTFTVVDK
MUL_2279|M.ulcerans_Agy99 EDRA---DPVPDGATGWHTVTFTVVDK
MAB_4441|M.abscessus_ATCC_1997 DQIA---SPVPDGATGYPKRLVTVAA-
Rv0218|M.tuberculosis_H37Rv HKR------------------------
MAV_2997|M.avium_104 RAGS---DA------------------
Mb1786|M.bovis_AF2122/97 ESAVSLWNPRGYGNNAWARVALRVS--
Mvan_5892|M.vanbaalenii_PYR-1 TSGHR--NAVHSVMVDVRDEEPWT---