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GIKESVTSAYTQFDAPDVAVEVYPPQEDSQLLVEAATAAGVLPGARVADLCTGSGVVALGAAASGAAEVT AFDICPKAVQRTRQDAVAAGADVDVHRGSWARAVEFGPYDVVLANPPYVPVPDADGETIPAAAGPSRAWD AGPDGRLVLDPMCAAAPLLLDEGGTMLVVQSECSNIQRTLTMLREHGMRTEVVAQQLIPFGPVMSVRAPW LMRAGLLPRGSRQERIVVIRADAP*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_5791 | - | - | 100% (235) | putative methylase |
| M. vanbaalenii PYR-1 | Mvan_4338 | - | 3e-15 | 32.84% (204) | HemK family modification methylase |
| M. vanbaalenii PYR-1 | Mvan_2166 | - | 3e-06 | 34.62% (130) | putative methyltransferase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1332 | hemK | 4e-09 | 26.70% (206) | hypothetical protein Mb1332 |
| M. gilvum PYR-GCK | Mflv_1039 | - | 3e-99 | 76.96% (230) | putative methylase |
| M. tuberculosis H37Rv | Rv1300 | hemK | 7e-09 | 26.70% (206) | hypothetical protein Rv1300 |
| M. leprae Br4923 | MLBr_00551 | - | 6e-08 | 34.83% (89) | putative methyltransferase |
| M. abscessus ATCC 19977 | MAB_2510c | - | 7e-53 | 53.37% (193) | putative methyltransferase |
| M. marinum M | MMAR_4097 | hemK | 1e-10 | 26.92% (182) | modification methylase HemK |
| M. avium 104 | MAV_0427 | - | 4e-63 | 53.33% (225) | methylase, putative |
| M. smegmatis MC2 155 | MSMEG_1771 | - | 3e-60 | 52.34% (214) | methylase, putative |
| M. thermoresistible (build 8) | TH_1710 | - | 8e-69 | 55.56% (243) | methylase, putative |
| M. ulcerans Agy99 | MUL_3964 | hemK | 4e-10 | 26.37% (182) | modification methylase HemK |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1332|M.bovis_AF2122/97 MTSAPATMRWGNLPLAGESGTMTLRQAIDLAAALLAEAGVDSARCDAEQL
Rv1300|M.tuberculosis_H37Rv MTSAPATMRWGNLPLAGESGTMTLRQAIDLAAALLAEAGVDSARCDAEQL
MMAR_4097|M.marinum_M MTS--------------------LRHAIDSAAALLAEAGIDSARGDAEWL
MUL_3964|M.ulcerans_Agy99 MTS--------------------LRHAIDSAAALLAEAGIDSARGDAEWL
Mvan_5791|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_1039|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_1771|M.smegmatis_MC2_155 --------------------------------------------------
TH_1710|M.thermoresistible__bu --------------------------------------------------
MAV_0427|M.avium_104 --------------------------------------------------
MAB_2510c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_00551|M.leprae_Br4923 --------------------------------------------------
Mb1332|M.bovis_AF2122/97 AAHLAGTDRGRLPLFEPPGD-EFFGRYRDIVTARARRVPLQHLIGTVSFG
Rv1300|M.tuberculosis_H37Rv AAHLAGTDRGRLPLFEPPGD-EFFGRYRDIVTARARRVPLQHLIGTVSFG
MMAR_4097|M.marinum_M AAHLTGTDRGLLYLPGEPLDTDALGQYRDMVTARSRRVPLQHLIGTVQFG
MUL_3964|M.ulcerans_Agy99 AAHLTGTDRGLLYLPDDPLDSDALGQYQDMVTARSRRVPLQHLIGTVQFG
Mvan_5791|M.vanbaalenii_PYR-1 ----------------MGIKESVTSAYTQFD-------------------
Mflv_1039|M.gilvum_PYR-GCK ----------------------MTSAYTDFD-------------------
MSMEG_1771|M.smegmatis_MC2_155 ----------------------MLAIAT----------------------
TH_1710|M.thermoresistible__bu ----------------------MMSLLDRRKADVTTAYTDVRDALDTAGR
MAV_0427|M.avium_104 ----------------------MTTTYPEP--------------------
MAB_2510c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_00551|M.leprae_Br4923 -----------------------MNLYTPIHEDQS---------LAAIHR
Mb1332|M.bovis_AF2122/97 PVVLHVGPGVFVPRPETEAILAWATAQSLPARPLIVDACTGSGALAVALA
Rv1300|M.tuberculosis_H37Rv PVVLHVGPGVFVPRPETEAILAWATAQSLPARPLIVDACTGSGALAVALA
MMAR_4097|M.marinum_M PVELQVGPGVFVPRPETEAVLEWAGAQQLSEYPVIVDLCTGSGALAIALA
MUL_3964|M.ulcerans_Agy99 PVELQVGPGVFVPRPETEAVLEWAGAQQLSEDPVIVDLCTGSGALAVALA
Mvan_5791|M.vanbaalenii_PYR-1 --APDVAVEVYPPQEDSQLLVEAATAAGVLPGARVADLCTGSGVVALGAA
Mflv_1039|M.gilvum_PYR-GCK --ARDLAVDVYPPQEDSHLLIDAMIEAGVVPGARVADLCTGSGVIAIAAA
MSMEG_1771|M.smegmatis_MC2_155 -------EGVYRPQEDSQLLIDALERSGEVPGRRVLDLCTGSGVVAIAAA
TH_1710|M.thermoresistible__bu SGGISAPPGVYAPQEDSRLLVDVLDRTGLAVDRRVVDLCTGSGVVAINAA
MAV_0427|M.avium_104 --AVLPAHNVYQPQEDSRLLVDVMHGTGLIPGRRVLDLCTGSGFVAIAAA
MAB_2510c|M.abscessus_ATCC_199 ------MTRFFPP-----------------AGLRVADLCTGSGYLALAAA
MLBr_00551|M.leprae_Br4923 AMWALGDYALMAEEVMAPLGPILVTATGIRPGMQVLDVAAGSGNISLPAA
. : * .:*** ::: *
Mb1332|M.bovis_AF2122/97 QHRANLGLKARIIGIDDSDCALDYARRNAAGTPVELVRADVTTPCLLPEL
Rv1300|M.tuberculosis_H37Rv QHRANLGLKARIIGIDDSDCALDYARRNAAGTPVELVRADVTTPRLLPEL
MMAR_4097|M.marinum_M DRWP----AARILGVDDSGAALEYAQRNSVGTKVELVRADVTTPGLMPEL
MUL_3964|M.ulcerans_Agy99 NRWP----TARILGVDDSAAALEYAHRNSVGTKVELVRADVTTPGLMPEL
Mvan_5791|M.vanbaalenii_PYR-1 ASGA-----AEVTAFDICPKAVQRTRQDAVAAGADVDVHRGS--WARAVE
Mflv_1039|M.gilvum_PYR-GCK AAGA-----ASVTAFDICPKAVQRTREEALAAGVEVDVHRGS--WARAVE
MSMEG_1771|M.smegmatis_MC2_155 HLGA-----EHVTALDICPRAVEYATANAASAAADVDVRLGT--WNEALN
TH_1710|M.thermoresistible__bu RQGA-----FHVSAFDICHRAVRCARANALSAGVDVDVRLGS--WARAVE
MAV_0427|M.avium_104 EMGC-----ASVTAFDKCPHAVRCARENAALAGVDVDVREGS--WLAAVD
MAB_2510c|M.abscessus_ATCC_199 KEGA-----AAVTALDMCPLAVECAQSNAQRVGADITALQGD--WLRAKE
MLBr_00551|M.leprae_Br4923 KTGA------TIVSTDLTPELLQRSQARATELGLTLEYREAD-AQALPFG
: . * : : : : .
Mb1332|M.bovis_AF2122/97 DGQVDLMVSNPPYIPDAAVLEP---EVAQHDPH-----HALFGG------
Rv1300|M.tuberculosis_H37Rv DGQVDLMVSNPPYIPDAAVLEP---EVAQHDPH-----HALFGG------
MMAR_4097|M.marinum_M DGQVDLVVTNPPYIPDGAVLEP---EVAQHDPH-----RALFGG------
MUL_3964|M.ulcerans_Agy99 DGQVDLVVTNPPYIPDGAVLEP---EVAQHDPH-----RALFGG------
Mvan_5791|M.vanbaalenii_PYR-1 FGPYDVVLANPPYVP-VPDADG-ETIPAAAGPS-----RAWDAG------
Mflv_1039|M.gilvum_PYR-GCK FRPFDVVLANPPYVPEAPMDDS-GLISATAGPS-----RAWDAG------
MSMEG_1771|M.smegmatis_MC2_155 WEPFDLVVCNPPYVPTSPAVDP-GSVAPWAGPA-----TAWDGG------
TH_1710|M.thermoresistible__bu FGPYDTVVCNPPYVPHGGDDDT-DRIPPHAGPP-----QAWNAG------
MAV_0427|M.avium_104 CAPFDVVVSNPPYVPTPPGAVL-DELGPVTGPS-----WAWNAG------
MAB_2510c|M.abscessus_ATCC_199 FGPFDLVLANPPYVPGDRRVLLGDAVPASVGTT-----LAFHAG------
MLBr_00551|M.leprae_Br4923 DGEFDVVMSAIGVMFAPDHRRAASELVRVCRPNGTIGVISWTQEGFFGRM
* :: : . :
Mb1332|M.bovis_AF2122/97 ----PDGMTVISAVVGLAGRWLRPGG-LFAVEHDDTTSSSTVDLVSSTKL
Rv1300|M.tuberculosis_H37Rv ----PDGMTVISAVVGLAGRWLRPGG-LFAVEHDDTTSSSTVDLVSSTKL
MMAR_4097|M.marinum_M ----PNGMAVIPHVVRLAGRWLRPGG-RFAVEHDDTTARQTVECIESEGV
MUL_3964|M.ulcerans_Agy99 ----PNGMAVIPHVVRLAGRWLRPGG-RFAVEHDDTTARQTVKCIESAGV
Mvan_5791|M.vanbaalenii_PYR-1 ----PDGRLVLDPMCAAAPLLLDEGGTMLVVQSECSNIQRTLTMLREHGM
Mflv_1039|M.gilvum_PYR-GCK ----PDGRVVLDPMCAAAPLLLAEGGTMLVVHSECSSVTRTLRAFRAQGM
MSMEG_1771|M.smegmatis_MC2_155 ----ADGRMILDPLCDVAGAMLAEGGSLFLVQSEFSGVEESLTRLSWSGL
TH_1710|M.thermoresistible__bu ----QNGRMVLDPLCAAAPALLADGGSLLVVHSEFSGVDQSLAALRTGGL
MAV_0427|M.avium_104 ----RDGRLVLDPLCESAPKLLRDGGSLLLVHSALAGVQQSLDSLKWAGM
MAB_2510c|M.abscessus_ATCC_199 ----VSGRLVLDPLCTHAHELLDPHGVLLLVQSEFADVSQTVYALAATGL
MLBr_00551|M.leprae_Br4923 LATIRPYRPSLSAALPPAALWGREAYIRGLLDDTVTNVKTERRQLEVKRF
: * :. : . .
Mb1332|M.bovis_AF2122/97 FVDVQARKDLA--GRPRFVTAMRWGHL---------------PLAGENGA
Rv1300|M.tuberculosis_H37Rv FVDVQARKDLA--GRPRFVTAMRWGHL---------------PLAGENGA
MMAR_4097|M.marinum_M FEDIVARQDLA--GRPRFVTAVKR-------------------LVR----
MUL_3964|M.ulcerans_Agy99 FEDIVARQDLA--GRPRFVTAVKR-------------------LVR----
Mvan_5791|M.vanbaalenii_PYR-1 RTEVVAQQLIP--FGPVMSVRAPWLMR---------------AGLLPRGS
Mflv_1039|M.gilvum_PYR-GCK KAEVVAQQLIP--FGPVMTARAPWLRR---------------AGLLGPNS
MSMEG_1771|M.smegmatis_MC2_155 KTEVVVTQSIP--WGPVVTAQADWLRE---------------TGRLHDGR
TH_1710|M.thermoresistible__bu NAEVIAEQWIP--FGPVLTARAAFLER---------------LGMLDPGR
MAV_0427|M.avium_104 DAKVIASKWIP--FGPVMLSRAHWLED---------------VGLIPRGR
MAB_2510c|M.abscessus_ATCC_199 TAEVIAEQHVP--FGPVMSARAPWLER---------------MGRLDKGR
MLBr_00551|M.leprae_Br4923 NSAEGVHNYFKNHYGPTIEAYTNIGDNSVLAAELDAQLTELAQKYLTNST
. : . * .
Mb1332|M.bovis_AF2122/97 IDPRQRRCRAKR-
Rv1300|M.tuberculosis_H37Rv IDPRQRRCRAKR-
MMAR_4097|M.marinum_M -------------
MUL_3964|M.ulcerans_Agy99 -------------
Mvan_5791|M.vanbaalenii_PYR-1 RQERIVVIRADAP
Mflv_1039|M.gilvum_PYR-GCK TQERIVVVRADAP
MSMEG_1771|M.smegmatis_MC2_155 DDEVLVVIRADKP
TH_1710|M.thermoresistible__bu REEQLVVIRADKP
MAV_0427|M.avium_104 REEELIVIRAEKR
MAB_2510c|M.abscessus_ATCC_199 RTERLVVIAGRRP
MLBr_00551|M.leprae_Br4923 MGWEYLLLTAQKH