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TSLRHAIDSAAALLAEAGIDSARGDAEWLAAHLTGTDRGLLYLPDDPLDSDALGQYQDMVTARSRRVPLQ HLIGTVQFGPVELQVGPGVFVPRPETEAVLEWAGAQQLSEDPVIVDLCTGSGALAVALANRWPTARILGV DDSAAALEYAHRNSVGTKVELVRADVTTPGLMPELDGQVDLVVTNPPYIPDGAVLEPEVAQHDPHRALFG GPNGMAVIPHVVRLAGRWLRPGGRFAVEHDDTTARQTVKCIESAGVFEDIVARQDLAGRPRFVTAVKRLV R*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_3964 | hemK | - | 100% (282) | modification methylase HemK |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1332 | hemK | 1e-109 | 72.14% (280) | hypothetical protein Mb1332 |
| M. gilvum PYR-GCK | Mflv_2308 | - | 3e-88 | 59.78% (276) | HemK family modification methylase |
| M. tuberculosis H37Rv | Rv1300 | hemK | 1e-109 | 72.14% (280) | hypothetical protein Rv1300 |
| M. leprae Br4923 | MLBr_01135 | - | 2e-99 | 64.31% (283) | putative protoporphyrinogen oxidase |
| M. abscessus ATCC 19977 | MAB_1443 | - | 2e-76 | 50.36% (280) | modification methylase HemK |
| M. marinum M | MMAR_4097 | hemK | 1e-155 | 95.74% (282) | modification methylase HemK |
| M. avium 104 | MAV_1517 | - | 1e-103 | 68.07% (285) | modification methylase, HemK family protein |
| M. smegmatis MC2 155 | MSMEG_4949 | - | 2e-98 | 63.31% (278) | modification methylase, HemK family protein |
| M. thermoresistible (build 8) | TH_1566 | hemK | 5e-90 | 60.14% (286) | PROBABLE HEMK PROTEIN HOMOLOG HEMK |
| M. vanbaalenii PYR-1 | Mvan_4338 | - | 2e-92 | 64.10% (273) | HemK family modification methylase |
CLUSTAL 2.0.9 multiple sequence alignment
MUL_3964|M.ulcerans_Agy99 --------------------MTSLRHAIDSAAALLAEAGIDSARGDAEWL
MMAR_4097|M.marinum_M --------------------MTSLRHAIDSAAALLAEAGIDSARGDAEWL
Mb1332|M.bovis_AF2122/97 MTSAPATMRWGNLPLAGESGTMTLRQAIDLAAALLAEAGVDSARCDAEQL
Rv1300|M.tuberculosis_H37Rv MTSAPATMRWGNLPLAGESGTMTLRQAIDLAAALLAEAGVDSARCDAEQL
MLBr_01135|M.leprae_Br4923 -------------------MMIRLRRAIDSAVTQLEEAGIGSARCDAEQL
MAV_1517|M.avium_104 --------------MSSGTIRLSLRRAIDDATATLAEAGIASARWDAEQL
MSMEG_4949|M.smegmatis_MC2_155 --------------------MTRLRTAIEAATATLAAAGVATPRIDAELL
TH_1566|M.thermoresistible__bu --------------------MTGLRQVIDAAARELTAAGVNSPRADALEL
Mflv_2308|M.gilvum_PYR-GCK --------------MTVADPPVTMRQVIADAAETLAAAGVGSPRVDAELL
Mvan_4338|M.vanbaalenii_PYR-1 --------------------------MIDDAAAVLAAAGVGSPRVDAELL
MAB_1443|M.abscessus_ATCC_1997 --------------------MSRLRELLAEAAESLSRAGVSSPQVDAEEL
: *. * **: :.: ** *
MUL_3964|M.ulcerans_Agy99 AAHLTGTDRGLLYLPDDPLDSDALGQYQDMVTARSRRVPLQHLIGTVQFG
MMAR_4097|M.marinum_M AAHLTGTDRGLLYLPGEPLDTDALGQYRDMVTARSRRVPLQHLIGTVQFG
Mb1332|M.bovis_AF2122/97 AAHLAGTDRGRLPLFEPPGD-EFFGRYRDIVTARARRVPLQHLIGTVSFG
Rv1300|M.tuberculosis_H37Rv AAHLAGTDRGRLPLFEPPGD-EFFGRYRDIVTARARRVPLQHLIGTVSFG
MLBr_01135|M.leprae_Br4923 AAHLAGTDRGRLALLDTPGE-EFFRRYSDAVAARSRRVPLQHLIGTVSFG
MAV_1517|M.avium_104 AAHLAGVDRGRLGLLESPGQ-EFFQRYRDAVLARARRVPLQHLLGTAAFG
MSMEG_4949|M.smegmatis_MC2_155 AAHSLGVDRGRLMFVDDPD-PEALAAFEHLVAARAKRIPLQHLVGTAAFG
TH_1566|M.thermoresistible__bu AAHAAGVDRGRLLLLDGPDDASFLARYRELVAARARRVPLQHLTGSAAFG
Mflv_2308|M.gilvum_PYR-GCK AAHVAGTDRGLVAFV-EPD-AAFLSRYRDLTARRAARVPLQHLTGTAAFG
Mvan_4338|M.vanbaalenii_PYR-1 AAHVTGTERGRVAFV-QPD-DAFAARYRELVTARAERVPLQHLTGTAAFG
MAB_1443|M.abscessus_ATCC_1997 AAHLLGVSRTQLRFTEAAA--DFPGRYRDLVAQRARRIPLQHLVGSAAFG
*** *..* : : . : . . *: *:***** *:. **
MUL_3964|M.ulcerans_Agy99 PVELQVGPGVFVPRPETEAVLEWAGAQQLS---EDPVIVDLCTGSGALAV
MMAR_4097|M.marinum_M PVELQVGPGVFVPRPETEAVLEWAGAQQLS---EYPVIVDLCTGSGALAI
Mb1332|M.bovis_AF2122/97 PVVLHVGPGVFVPRPETEAILAWATAQSLP---ARPLIVDACTGSGALAV
Rv1300|M.tuberculosis_H37Rv PVVLHVGPGVFVPRPETEAILAWATAQSLP---ARPLIVDACTGSGALAV
MLBr_01135|M.leprae_Br4923 PVVLHVGPDVFIPRPETEAILAWVMAQRLP---ERPVIVDACTGSGALAV
MAV_1517|M.avium_104 PVLLHVGPGVFVPRPETEALLEWATAQQLP---PRPVIVDLCTGSGALAV
MSMEG_4949|M.smegmatis_MC2_155 PLTLEVGPGVFIPRPETESLLEWAVAQQLP---RDAVIVDLCTGTGALAL
TH_1566|M.thermoresistible__bu PVTLSVGPGVFIPRPETEALLDWAVRHALPDLGPRPVIADLCTGSGALAL
Mflv_2308|M.gilvum_PYR-GCK PVVVDVGPGVFIPRPETESLLEWALAQPLS---GSARIVDLCTGSGALAL
Mvan_4338|M.vanbaalenii_PYR-1 PVTVQVGPGVFVPRPETESVLEWAVAQPLP---ARPRIVDLCTGSGALAL
MAB_1443|M.abscessus_ATCC_1997 PIEVRVGPGVFIPRPETESLYAWAAGQLAP----HATVVELCAGSAALAI
*: : ***.**:******:: *. : . . :.: *:*:.***:
MUL_3964|M.ulcerans_Agy99 ALANRWP----TARILGVDDSAAALEYAHRNSVGTKVELVRADVT----T
MMAR_4097|M.marinum_M ALADRWP----AARILGVDDSGAALEYAQRNSVGTKVELVRADVT----T
Mb1332|M.bovis_AF2122/97 ALAQHRANLGLKARIIGIDDSDCALDYARRNAAGTPVELVRADVT----T
Rv1300|M.tuberculosis_H37Rv ALAQHRANLGLKARIIGIDDSDCALDYARRNAAGTPVELVRADVT----T
MLBr_01135|M.leprae_Br4923 ALAHHRP----AARVIGIDDSDSALDYARRNAEGTAVECVRADVT----T
MAV_1517|M.avium_104 ALAHHRAGRGLPARIVGVDNSDAALEYARRNAAGTTVELVRADVIELARV
MSMEG_4949|M.smegmatis_MC2_155 ALAQHRP----QARVIAVEDSPAALEYARCNAAGTSVEVLAADVT----A
TH_1566|M.thermoresistible__bu ALHHHRP----DARIIAVDISDAALEYARRNTAGTGIEVLRTDVT----A
Mflv_2308|M.gilvum_PYR-GCK ALAQGFP----GATVFAVDDSDDALVYTRRNTAGTAVHVVRADVT----D
Mvan_4338|M.vanbaalenii_PYR-1 ALAVAFP----AAQVTAVDDSEAALDYARGNVADSSVQLVRADVT----A
MAB_1443|M.abscessus_ATCC_1997 ALAQHEP----TARVTAIEVDVDALIYTRRNAEGTGVEVVQADVT----S
** . * : .:: . ** *:: * .: :. : :**
MUL_3964|M.ulcerans_Agy99 PGLMPELDGQVDLVVTNPPYIPD-----GAVLEPEVAQHDPHRALFGGPN
MMAR_4097|M.marinum_M PGLMPELDGQVDLVVTNPPYIPD-----GAVLEPEVAQHDPHRALFGGPN
Mb1332|M.bovis_AF2122/97 PCLLPELDGQVDLMVSNPPYIPD-----AAVLEPEVAQHDPHHALFGGPD
Rv1300|M.tuberculosis_H37Rv PRLLPELDGQVDLMVSNPPYIPD-----AAVLEPEVAQHDPHHALFGGPD
MLBr_01135|M.leprae_Br4923 PALLPELDGCVDLFVANPPYVPDDPV-VQSILEPEVTQYDPRHAVFGGPD
MAV_1517|M.avium_104 PGSAPDLDGRVDLVVANPPYVPD-----GAVLEPEVAQHDPHHAVFGGPD
MSMEG_4949|M.smegmatis_MC2_155 PDLLPELDGAVDLVVSNPPYIPEG-----AELDPEVADHDPAHALFGGPD
TH_1566|M.thermoresistible__bu PELLAGLAGQVDLIVANPPYIPAPSVPAESGLEPEVARHDPPDALFGGPD
Mflv_2308|M.gilvum_PYR-GCK AGLLTELDRSVDLLVSNPPYIPDA-----AELEPEVAEHDPAHALYGGAD
Mvan_4338|M.vanbaalenii_PYR-1 PGLLADLDGSVDLLVANPPYIPAG-----ALLEPEVAQYDPAHALFGGAD
MAB_1443|M.abscessus_ATCC_1997 PDLLTELNGAVDLIVANPPYIPQD-----TELEPEVARHDPPQALFAGAD
. . * ***.*:****:* : *:***: :** *::.*.:
MUL_3964|M.ulcerans_Agy99 GMAVIPHVVRLAGRWLRPGGRFAVEHDDTTARQTVKCIESAGVFEDIVAR
MMAR_4097|M.marinum_M GMAVIPHVVRLAGRWLRPGGRFAVEHDDTTARQTVECIESEGVFEDIVAR
Mb1332|M.bovis_AF2122/97 GMTVISAVVGLAGRWLRPGGLFAVEHDDTTSSSTVDLVSSTKLFVDVQAR
Rv1300|M.tuberculosis_H37Rv GMTVISAVVGLAGRWLRPGGLFAVEHDDTTSSSTVDLVSSTKLFVDVQAR
MLBr_01135|M.leprae_Br4923 GMALTADIVGLAGRWLRPGGLFAVEHDDSTSVPTLDLVYRTDLFDDVLTH
MAV_1517|M.avium_104 GLAVIAPVVELAGRWLRPGGLIGIEHDDTTSHQTVELFDRTGLFDDVRAH
MSMEG_4949|M.smegmatis_MC2_155 GMAVIRPIVALAARWLRDGGKCAVEHDDTTSARTVEAFTHDGNFTDVTAR
TH_1566|M.thermoresistible__bu GMAVITAIVDRAGVLLRPGGRCAIEHDDTTSAETVTAFTGTGRFVDVVAR
Mflv_2308|M.gilvum_PYR-GCK GMAVIEHLAGVAARLLRPGGRCAVEHDDSTSQATVEVFVRAGGFTEVTAR
Mvan_4338|M.vanbaalenii_PYR-1 GMSVIGPIVDAAARLLRPGGRCAVEHDDTTSEQTVAAFTRDGGFVDVTAR
MAB_1443|M.abscessus_ATCC_1997 GLAIIAPIVIAAGRLLAPGGAIGIEHDDSKGGRTRELFTACDFFDEVVQR
*::: :. *. * ** .:****:.. * . * :: :
MUL_3964|M.ulcerans_Agy99 QDLAGRPRFVTAVKRLVR--------------------
MMAR_4097|M.marinum_M QDLAGRPRFVTAVKRLVR--------------------
Mb1332|M.bovis_AF2122/97 KDLAGRPRFVTAMRWGHLPLAGENGAIDPRQRRCRAKR
Rv1300|M.tuberculosis_H37Rv KDLAGRPRFVTAMRWGHLPLAGENGAIDPRQRRCRAKR
MLBr_01135|M.leprae_Br4923 RDLAGRPRFVTARRRESWSA------------------
MAV_1517|M.avium_104 RDLTGRPRFVTARRRSGADVSRRDDAERSDEEERR---
MSMEG_4949|M.smegmatis_MC2_155 HDLTGRPRFVTATRIARS--------------------
TH_1566|M.thermoresistible__bu RDLAGRPRFVTATRLGRGHQDSGHQEGLTR--------
Mflv_2308|M.gilvum_PYR-GCK HDLTGRPRFVTAVRNGERVAR-----------------
Mvan_4338|M.vanbaalenii_PYR-1 HDLAGRPRFVTAVRAG----------------------
MAB_1443|M.abscessus_ATCC_1997 HDLTGRPRFVTARRKIAAS-------------------
:**:******** :