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MLAIATEGVYRPQEDSQLLIDALERSGEVPGRRVLDLCTGSGVVAIAAAHLGAEHVTALDICPRAVEYAT ANAASAAADVDVRLGTWNEALNWEPFDLVVCNPPYVPTSPAVDPGSVAPWAGPATAWDGGADGRMILDPL CDVAGAMLAEGGSLFLVQSEFSGVEESLTRLSWSGLKTEVVVTQSIPWGPVVTAQADWLRETGRLHDGRD DEVLVVIRADKP
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_1771 | - | - | 100% (222) | methylase, putative |
| M. smegmatis MC2 155 | MSMEG_4949 | - | 9e-15 | 35.57% (149) | modification methylase, HemK family protein |
| M. smegmatis MC2 155 | MSMEG_1892 | - | 1e-09 | 34.62% (130) | transferase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1332 | hemK | 2e-12 | 29.00% (200) | hypothetical protein Mb1332 |
| M. gilvum PYR-GCK | Mflv_1039 | - | 1e-62 | 53.74% (214) | putative methylase |
| M. tuberculosis H37Rv | Rv1300 | hemK | 2e-12 | 29.00% (200) | hypothetical protein Rv1300 |
| M. leprae Br4923 | MLBr_01135 | - | 3e-12 | 32.81% (192) | putative protoporphyrinogen oxidase |
| M. abscessus ATCC 19977 | MAB_2510c | - | 2e-44 | 48.70% (193) | putative methyltransferase |
| M. marinum M | MMAR_4097 | hemK | 1e-12 | 29.10% (189) | modification methylase HemK |
| M. avium 104 | MAV_0427 | - | 3e-64 | 52.29% (218) | methylase, putative |
| M. thermoresistible (build 8) | TH_1710 | - | 6e-69 | 59.63% (218) | methylase, putative |
| M. ulcerans Agy99 | MUL_3964 | hemK | 4e-12 | 28.04% (189) | modification methylase HemK |
| M. vanbaalenii PYR-1 | Mvan_5791 | - | 2e-60 | 52.34% (214) | putative methylase |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_1771|M.smegmatis_MC2_155 --------------------------------------------------
TH_1710|M.thermoresistible__bu --------------------------------------------------
MAV_0427|M.avium_104 --------------------------------------------------
Mflv_1039|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5791|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_2510c|M.abscessus_ATCC_199 --------------------------------------------------
Mb1332|M.bovis_AF2122/97 MTSAPATMRWGNLPLAGESGTMTLRQAIDLAAALLAEAGVDSARCDAEQL
Rv1300|M.tuberculosis_H37Rv MTSAPATMRWGNLPLAGESGTMTLRQAIDLAAALLAEAGVDSARCDAEQL
MLBr_01135|M.leprae_Br4923 -------------------MMIRLRRAIDSAVTQLEEAGIGSARCDAEQL
MMAR_4097|M.marinum_M --------------------MTSLRHAIDSAAALLAEAGIDSARGDAEWL
MUL_3964|M.ulcerans_Agy99 --------------------MTSLRHAIDSAAALLAEAGIDSARGDAEWL
MSMEG_1771|M.smegmatis_MC2_155 ----------------------MLAIAT----------------------
TH_1710|M.thermoresistible__bu ----------------------MMSLLDRRKADVTTAYTDVRDALDTAGR
MAV_0427|M.avium_104 ----------------------MTTTYPEP--------------------
Mflv_1039|M.gilvum_PYR-GCK ----------------------MTSAYTDFD-------------------
Mvan_5791|M.vanbaalenii_PYR-1 ----------------MGIKESVTSAYTQFD-------------------
MAB_2510c|M.abscessus_ATCC_199 --------------------------------------------------
Mb1332|M.bovis_AF2122/97 AAHLAGTDRGRLPLFEPPGD-EFFGRYRDIVTARARRVPLQHLIGTVSFG
Rv1300|M.tuberculosis_H37Rv AAHLAGTDRGRLPLFEPPGD-EFFGRYRDIVTARARRVPLQHLIGTVSFG
MLBr_01135|M.leprae_Br4923 AAHLAGTDRGRLALLDTPGE-EFFRRYSDAVAARSRRVPLQHLIGTVSFG
MMAR_4097|M.marinum_M AAHLTGTDRGLLYLPGEPLDTDALGQYRDMVTARSRRVPLQHLIGTVQFG
MUL_3964|M.ulcerans_Agy99 AAHLTGTDRGLLYLPDDPLDSDALGQYQDMVTARSRRVPLQHLIGTVQFG
MSMEG_1771|M.smegmatis_MC2_155 -------EGVYRPQEDSQLLIDALERSGEVPGRRVLDLCTGSGVVAIAAA
TH_1710|M.thermoresistible__bu SGGISAPPGVYAPQEDSRLLVDVLDRTGLAVDRRVVDLCTGSGVVAINAA
MAV_0427|M.avium_104 --AVLPAHNVYQPQEDSRLLVDVMHGTGLIPGRRVLDLCTGSGFVAIAAA
Mflv_1039|M.gilvum_PYR-GCK --ARDLAVDVYPPQEDSHLLIDAMIEAGVVPGARVADLCTGSGVIAIAAA
Mvan_5791|M.vanbaalenii_PYR-1 --APDVAVEVYPPQEDSQLLVEAATAAGVLPGARVADLCTGSGVVALGAA
MAB_2510c|M.abscessus_ATCC_199 ------MTRFFPP-----------------AGLRVADLCTGSGYLALAAA
Mb1332|M.bovis_AF2122/97 PVVLHVGPGVFVPRPETEAILAWATAQSLPARPLIVDACTGSGALAVALA
Rv1300|M.tuberculosis_H37Rv PVVLHVGPGVFVPRPETEAILAWATAQSLPARPLIVDACTGSGALAVALA
MLBr_01135|M.leprae_Br4923 PVVLHVGPDVFIPRPETEAILAWVMAQRLPERPVIVDACTGSGALAVALA
MMAR_4097|M.marinum_M PVELQVGPGVFVPRPETEAVLEWAGAQQLSEYPVIVDLCTGSGALAIALA
MUL_3964|M.ulcerans_Agy99 PVELQVGPGVFVPRPETEAVLEWAGAQQLSEDPVIVDLCTGSGALAVALA
.: * : * ***** :*: *
MSMEG_1771|M.smegmatis_MC2_155 HLGA-----EHVTALDICPRAVEYATANAASAAADVDVRLGT--WNEALN
TH_1710|M.thermoresistible__bu RQGA-----FHVSAFDICHRAVRCARANALSAGVDVDVRLGS--WARAVE
MAV_0427|M.avium_104 EMGC-----ASVTAFDKCPHAVRCARENAALAGVDVDVREGS--WLAAVD
Mflv_1039|M.gilvum_PYR-GCK AAGA-----ASVTAFDICPKAVQRTREEALAAGVEVDVHRGS--WARAVE
Mvan_5791|M.vanbaalenii_PYR-1 ASGA-----AEVTAFDICPKAVQRTRQDAVAAGADVDVHRGS--WARAVE
MAB_2510c|M.abscessus_ATCC_199 KEGA-----AAVTALDMCPLAVECAQSNAQRVGADITALQGD--WLRAKE
Mb1332|M.bovis_AF2122/97 QHRANLGLKARIIGIDDSDCALDYARRNAAGTPVELVRADVTTPCLLPEL
Rv1300|M.tuberculosis_H37Rv QHRANLGLKARIIGIDDSDCALDYARRNAAGTPVELVRADVTTPRLLPEL
MLBr_01135|M.leprae_Br4923 HHRP----AARVIGIDDSDSALDYARRNAEGTAVECVRADVTTPALLPEL
MMAR_4097|M.marinum_M DRWP----AARILGVDDSGAALEYAQRNSVGTKVELVRADVTTPGLMPEL
MUL_3964|M.ulcerans_Agy99 NRWP----TARILGVDDSAAALEYAHRNSVGTKVELVRADVTTPGLMPEL
: ..* . *: : :: . .: .
MSMEG_1771|M.smegmatis_MC2_155 WEPFDLVVCNPPYVPT-SPAVDP-GSVAPWAGPATAWDGGADGRMILDPL
TH_1710|M.thermoresistible__bu FGPYDTVVCNPPYVPH-GGDDDT-DRIPPHAGPPQAWNAGQNGRMVLDPL
MAV_0427|M.avium_104 CAPFDVVVSNPPYVPT-PPGAVL-DELGPVTGPSWAWNAGRDGRLVLDPL
Mflv_1039|M.gilvum_PYR-GCK FRPFDVVLANPPYVPE-APMDDS-GLISATAGPSRAWDAGPDGRVVLDPM
Mvan_5791|M.vanbaalenii_PYR-1 FGPYDVVLANPPYVP--VPDADG-ETIPAAAGPSRAWDAGPDGRLVLDPM
MAB_2510c|M.abscessus_ATCC_199 FGPFDLVLANPPYVPG-DRRVLLGDAVPASVGTTLAFHAGVSGRLVLDPL
Mb1332|M.bovis_AF2122/97 DGQVDLMVSNPPYIPD----AAVLEPEVAQHDPHHALFGGPDGMTVISAV
Rv1300|M.tuberculosis_H37Rv DGQVDLMVSNPPYIPD----AAVLEPEVAQHDPHHALFGGPDGMTVISAV
MLBr_01135|M.leprae_Br4923 DGCVDLFVANPPYVPDDPVVQSILEPEVTQYDPRHAVFGGPDGMALTADI
MMAR_4097|M.marinum_M DGQVDLVVTNPPYIPD----GAVLEPEVAQHDPHRALFGGPNGMAVIPHV
MUL_3964|M.ulcerans_Agy99 DGQVDLVVTNPPYIPD----GAVLEPEVAQHDPHRALFGGPNGMAVIPHV
* .: ****:* . .. * .* .* : :
MSMEG_1771|M.smegmatis_MC2_155 CDVAGAMLAEGGSLFLVQSEFSGVEESLTRLSWSGLKTEVVVTQSIPWGP
TH_1710|M.thermoresistible__bu CAAAPALLADGGSLLVVHSEFSGVDQSLAALRTGGLNAEVIAEQWIPFGP
MAV_0427|M.avium_104 CESAPKLLRDGGSLLLVHSALAGVQQSLDSLKWAGMDAKVIASKWIPFGP
Mflv_1039|M.gilvum_PYR-GCK CAAAPLLLAEGGTMLVVHSECSSVTRTLRAFRAQGMKAEVVAQQLIPFGP
Mvan_5791|M.vanbaalenii_PYR-1 CAAAPLLLDEGGTMLVVQSECSNIQRTLTMLREHGMRTEVVAQQLIPFGP
MAB_2510c|M.abscessus_ATCC_199 CTHAHELLDPHGVLLLVQSEFADVSQTVYALAATGLTAEVIAEQHVPFGP
Mb1332|M.bovis_AF2122/97 VGLAGRWLRPGG-LFAVEHDDTTSSSTVDLVSSTKLFVDVQARKDLAGRP
Rv1300|M.tuberculosis_H37Rv VGLAGRWLRPGG-LFAVEHDDTTSSSTVDLVSSTKLFVDVQARKDLAGRP
MLBr_01135|M.leprae_Br4923 VGLAGRWLRPGG-LFAVEHDDSTSVPTLDLVYRTDLFDDVLTHRDLAGRP
MMAR_4097|M.marinum_M VRLAGRWLRPGG-RFAVEHDDTTARQTVECIESEGVFEDIVARQDLAGRP
MUL_3964|M.ulcerans_Agy99 VRLAGRWLRPGG-RFAVEHDDTTARQTVKCIESAGVFEDIVARQDLAGRP
* * * : *. : :: . : .: . : :. *
MSMEG_1771|M.smegmatis_MC2_155 VVTAQADWLRETGRLHDGRDDEVLVVIRADKP
TH_1710|M.thermoresistible__bu VLTARAAFLERLGMLDPGRREEQLVVIRADKP
MAV_0427|M.avium_104 VMLSRAHWLEDVGLIPRGRREEELIVIRAEKR
Mflv_1039|M.gilvum_PYR-GCK VMTARAPWLRRAGLLGPNSTQERIVVVRADAP
Mvan_5791|M.vanbaalenii_PYR-1 VMSVRAPWLMRAGLLPRGSRQERIVVIRADAP
MAB_2510c|M.abscessus_ATCC_199 VMSARAPWLERMGRLDKGRRTERLVVIAGRRP
Mb1332|M.bovis_AF2122/97 RFVTAMRWGHLPLAGENGAIDPRQRRCRAKR-
Rv1300|M.tuberculosis_H37Rv RFVTAMRWGHLPLAGENGAIDPRQRRCRAKR-
MLBr_01135|M.leprae_Br4923 RFVTARRRESWSA-------------------
MMAR_4097|M.marinum_M RFVTAVKRLVR---------------------
MUL_3964|M.ulcerans_Agy99 RFVTAVKRLVR---------------------
.