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M. thermoresistible (build 8) TH_1710 (-)

annotation: methylase, putative
coordinates: 3293410 - 3294165
length: 252

aa seq not available

Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. thermoresistible (build 8)TH_1710--100% (252)methylase, putative
M. thermoresistible (build 8)TH_1566hemK1e-1230.60% (183) PROBABLE HEMK PROTEIN HOMOLOG HEMK
M. thermoresistible (build 8)TH_0663-7e-0733.58% (137) transferase

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb1332hemK4e-0827.16% (162) hypothetical protein Mb1332
M. gilvum PYR-GCKMflv_1039-2e-7157.08% (240) putative methylase
M. tuberculosis H37RvRv1300hemK4e-0827.16% (162) hypothetical protein Rv1300
M. leprae Br4923MLBr_01135-1e-0628.14% (167) putative protoporphyrinogen oxidase
M. abscessus ATCC 19977MAB_2510c-2e-5153.89% (193) putative methyltransferase
M. marinum MMMAR_4097hemK7e-1228.57% (182) modification methylase HemK
M. avium 104MAV_0427-3e-7161.97% (213) methylase, putative
M. smegmatis MC2 155MSMEG_1771-1e-6859.63% (218) methylase, putative
M. ulcerans Agy99MUL_3964hemK1e-1228.02% (182) modification methylase HemK
M. vanbaalenii PYR-1Mvan_5791-1e-6855.56% (243) putative methylase

CLUSTAL 2.0.9 multiple sequence alignment


TH_1710|M.thermoresistible__bu      --------------------------------------------------
MSMEG_1771|M.smegmatis_MC2_155      --------------------------------------------------
MAV_0427|M.avium_104                --------------------------------------------------
Mflv_1039|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_5791|M.vanbaalenii_PYR-1       --------------------------------------------------
MAB_2510c|M.abscessus_ATCC_199      --------------------------------------------------
Mb1332|M.bovis_AF2122/97            MTSAPATMRWGNLPLAGESGTMTLRQAIDLAAALLAEAGVDSARCDAEQL
Rv1300|M.tuberculosis_H37Rv         MTSAPATMRWGNLPLAGESGTMTLRQAIDLAAALLAEAGVDSARCDAEQL
MLBr_01135|M.leprae_Br4923          -------------------MMIRLRRAIDSAVTQLEEAGIGSARCDAEQL
MMAR_4097|M.marinum_M               --------------------MTSLRHAIDSAAALLAEAGIDSARGDAEWL
MUL_3964|M.ulcerans_Agy99           --------------------MTSLRHAIDSAAALLAEAGIDSARGDAEWL
                                                                                      

TH_1710|M.thermoresistible__bu      ----------------------MMSLLDRRKADVTTAYTDVRDALDTAGR
MSMEG_1771|M.smegmatis_MC2_155      ----------------------MLAIAT----------------------
MAV_0427|M.avium_104                ----------------------MTTTYPEP--------------------
Mflv_1039|M.gilvum_PYR-GCK          ----------------------MTSAYTDFD-------------------
Mvan_5791|M.vanbaalenii_PYR-1       ----------------MGIKESVTSAYTQFD-------------------
MAB_2510c|M.abscessus_ATCC_199      --------------------------------------------------
Mb1332|M.bovis_AF2122/97            AAHLAGTDRGRLPLFEPPGD-EFFGRYRDIVTARARRVPLQHLIGTVSFG
Rv1300|M.tuberculosis_H37Rv         AAHLAGTDRGRLPLFEPPGD-EFFGRYRDIVTARARRVPLQHLIGTVSFG
MLBr_01135|M.leprae_Br4923          AAHLAGTDRGRLALLDTPGE-EFFRRYSDAVAARSRRVPLQHLIGTVSFG
MMAR_4097|M.marinum_M               AAHLTGTDRGLLYLPGEPLDTDALGQYRDMVTARSRRVPLQHLIGTVQFG
MUL_3964|M.ulcerans_Agy99           AAHLTGTDRGLLYLPDDPLDSDALGQYQDMVTARSRRVPLQHLIGTVQFG
                                                                                      

TH_1710|M.thermoresistible__bu      SGGISAPPGVYAPQEDSRLLVDVLDRTGLAVDRRVVDLCTGSGVVAINAA
MSMEG_1771|M.smegmatis_MC2_155      -------EGVYRPQEDSQLLIDALERSGEVPGRRVLDLCTGSGVVAIAAA
MAV_0427|M.avium_104                --AVLPAHNVYQPQEDSRLLVDVMHGTGLIPGRRVLDLCTGSGFVAIAAA
Mflv_1039|M.gilvum_PYR-GCK          --ARDLAVDVYPPQEDSHLLIDAMIEAGVVPGARVADLCTGSGVIAIAAA
Mvan_5791|M.vanbaalenii_PYR-1       --APDVAVEVYPPQEDSQLLVEAATAAGVLPGARVADLCTGSGVVALGAA
MAB_2510c|M.abscessus_ATCC_199      ------MTRFFPP-----------------AGLRVADLCTGSGYLALAAA
Mb1332|M.bovis_AF2122/97            PVVLHVGPGVFVPRPETEAILAWATAQSLPARPLIVDACTGSGALAVALA
Rv1300|M.tuberculosis_H37Rv         PVVLHVGPGVFVPRPETEAILAWATAQSLPARPLIVDACTGSGALAVALA
MLBr_01135|M.leprae_Br4923          PVVLHVGPDVFIPRPETEAILAWVMAQRLPERPVIVDACTGSGALAVALA
MMAR_4097|M.marinum_M               PVELQVGPGVFVPRPETEAVLEWAGAQQLSEYPVIVDLCTGSGALAIALA
MUL_3964|M.ulcerans_Agy99           PVELQVGPGVFVPRPETEAVLEWAGAQQLSEDPVIVDLCTGSGALAVALA
                                             .: *                     : * ***** :*:  *

TH_1710|M.thermoresistible__bu      RQGA-----FHVSAFDICHRAVRCARANALSAGVDVDVRLGS--WARAVE
MSMEG_1771|M.smegmatis_MC2_155      HLGA-----EHVTALDICPRAVEYATANAASAAADVDVRLGT--WNEALN
MAV_0427|M.avium_104                EMGC-----ASVTAFDKCPHAVRCARENAALAGVDVDVREGS--WLAAVD
Mflv_1039|M.gilvum_PYR-GCK          AAGA-----ASVTAFDICPKAVQRTREEALAAGVEVDVHRGS--WARAVE
Mvan_5791|M.vanbaalenii_PYR-1       ASGA-----AEVTAFDICPKAVQRTRQDAVAAGADVDVHRGS--WARAVE
MAB_2510c|M.abscessus_ATCC_199      KEGA-----AAVTALDMCPLAVECAQSNAQRVGADITALQGD--WLRAKE
Mb1332|M.bovis_AF2122/97            QHRANLGLKARIIGIDDSDCALDYARRNAAGTPVELVRADVTTPCLLPEL
Rv1300|M.tuberculosis_H37Rv         QHRANLGLKARIIGIDDSDCALDYARRNAAGTPVELVRADVTTPRLLPEL
MLBr_01135|M.leprae_Br4923          HHRP----AARVIGIDDSDSALDYARRNAEGTAVECVRADVTTPALLPEL
MMAR_4097|M.marinum_M               DRWP----AARILGVDDSGAALEYAQRNSVGTKVELVRADVTTPGLMPEL
MUL_3964|M.ulcerans_Agy99           NRWP----TARILGVDDSAAALEYAHRNSVGTKVELVRADVTTPGLMPEL
                                               : ..* .  *:  :  ::  . .:            .  

TH_1710|M.thermoresistible__bu      FGPYDTVVCNPPYVPH-GGDDDT-DRIPPHAGPPQAWNAGQNGRMVLDPL
MSMEG_1771|M.smegmatis_MC2_155      WEPFDLVVCNPPYVPT-SPAVDP-GSVAPWAGPATAWDGGADGRMILDPL
MAV_0427|M.avium_104                CAPFDVVVSNPPYVPT-PPGAVL-DELGPVTGPSWAWNAGRDGRLVLDPL
Mflv_1039|M.gilvum_PYR-GCK          FRPFDVVLANPPYVPE-APMDDS-GLISATAGPSRAWDAGPDGRVVLDPM
Mvan_5791|M.vanbaalenii_PYR-1       FGPYDVVLANPPYVP--VPDADG-ETIPAAAGPSRAWDAGPDGRLVLDPM
MAB_2510c|M.abscessus_ATCC_199      FGPFDLVLANPPYVPG-DRRVLLGDAVPASVGTTLAFHAGVSGRLVLDPL
Mb1332|M.bovis_AF2122/97            DGQVDLMVSNPPYIPD----AAVLEPEVAQHDPHHALFGGPDGMTVISAV
Rv1300|M.tuberculosis_H37Rv         DGQVDLMVSNPPYIPD----AAVLEPEVAQHDPHHALFGGPDGMTVISAV
MLBr_01135|M.leprae_Br4923          DGCVDLFVANPPYVPDDPVVQSILEPEVTQYDPRHAVFGGPDGMALTADI
MMAR_4097|M.marinum_M               DGQVDLVVTNPPYIPD----GAVLEPEVAQHDPHRALFGGPNGMAVIPHV
MUL_3964|M.ulcerans_Agy99           DGQVDLVVTNPPYIPD----GAVLEPEVAQHDPHRALFGGPNGMAVIPHV
                                        * .: ****:*             .  ..  *  .* .*  :   :

TH_1710|M.thermoresistible__bu      CAAAPALLADGGSLLVVHSEFSGVDQSLAALRTGGLNAEVIAEQWIPFGP
MSMEG_1771|M.smegmatis_MC2_155      CDVAGAMLAEGGSLFLVQSEFSGVEESLTRLSWSGLKTEVVVTQSIPWGP
MAV_0427|M.avium_104                CESAPKLLRDGGSLLLVHSALAGVQQSLDSLKWAGMDAKVIASKWIPFGP
Mflv_1039|M.gilvum_PYR-GCK          CAAAPLLLAEGGTMLVVHSECSSVTRTLRAFRAQGMKAEVVAQQLIPFGP
Mvan_5791|M.vanbaalenii_PYR-1       CAAAPLLLDEGGTMLVVQSECSNIQRTLTMLREHGMRTEVVAQQLIPFGP
MAB_2510c|M.abscessus_ATCC_199      CTHAHELLDPHGVLLLVQSEFADVSQTVYALAATGLTAEVIAEQHVPFGP
Mb1332|M.bovis_AF2122/97            VGLAGRWLRPGG-LFAVEHDDTTSSSTVDLVSSTKLFVDVQARKDLAGRP
Rv1300|M.tuberculosis_H37Rv         VGLAGRWLRPGG-LFAVEHDDTTSSSTVDLVSSTKLFVDVQARKDLAGRP
MLBr_01135|M.leprae_Br4923          VGLAGRWLRPGG-LFAVEHDDSTSVPTLDLVYRTDLFDDVLTHRDLAGRP
MMAR_4097|M.marinum_M               VRLAGRWLRPGG-RFAVEHDDTTARQTVECIESEGVFEDIVARQDLAGRP
MUL_3964|M.ulcerans_Agy99           VRLAGRWLRPGG-RFAVEHDDTTARQTVKCIESAGVFEDIVARQDLAGRP
                                       *   *   *  : *.   :    ::  .    :  .: . : :.  *

TH_1710|M.thermoresistible__bu      VLTARAAFLERLGMLDPGRREEQLVVIRADKP
MSMEG_1771|M.smegmatis_MC2_155      VVTAQADWLRETGRLHDGRDDEVLVVIRADKP
MAV_0427|M.avium_104                VMLSRAHWLEDVGLIPRGRREEELIVIRAEKR
Mflv_1039|M.gilvum_PYR-GCK          VMTARAPWLRRAGLLGPNSTQERIVVVRADAP
Mvan_5791|M.vanbaalenii_PYR-1       VMSVRAPWLMRAGLLPRGSRQERIVVIRADAP
MAB_2510c|M.abscessus_ATCC_199      VMSARAPWLERMGRLDKGRRTERLVVIAGRRP
Mb1332|M.bovis_AF2122/97            RFVTAMRWGHLPLAGENGAIDPRQRRCRAKR-
Rv1300|M.tuberculosis_H37Rv         RFVTAMRWGHLPLAGENGAIDPRQRRCRAKR-
MLBr_01135|M.leprae_Br4923          RFVTARRRESWSA-------------------
MMAR_4097|M.marinum_M               RFVTAVKRLVR---------------------
MUL_3964|M.ulcerans_Agy99           RFVTAVKRLVR---------------------
                                     .