For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
GNQYLEGAFAPVANEYTLTGLDVVGDIPAYLDGRYLRNGPNPVAEVDPELYHWFTGDGMVHGIRIRDGKA EWYRNRWVRSPRVAEALGETPPRGDYGLTPIGANTNVIGHAGKTLALIEAGVAQYELTDDLDAVDVCDFD GTLAGGYTAHPKRDPGTGELHAVSYCLLNGNTVQYSVVGVDGRARRTVDVEVTGSPMMHDFSLTERHVVF YDLPVTFDSRQAATIGVPRWLQLPARLVLSALIGRVRIPDPLAARRPGRDSSDAAFPYSWNPRYPARVGV MPREGGNGDVRWFEVEPCYVFHPMNAFDDGDTVVLDVVRHEKMFATDHLGPNEGIPTLERWTVDLADGKV RESRIDDRGQEFPRVDERVVGRRHRYGYAPTVTGGGSCADTLLKHDFVGTGSVARSFGAGKTLGEFVFHP SSPDAAEDDGVLMGYIYDRPTDRSQLAILDAATLDDVAAVNLPHRVPAGFHGNWVPTA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_4595 | - | - | 100% (479) | carotenoid oxygenase |
| M. vanbaalenii PYR-1 | Mvan_5460 | - | 3e-90 | 40.75% (481) | carotenoid oxygenase |
| M. vanbaalenii PYR-1 | Mvan_4940 | - | 1e-46 | 30.76% (543) | carotenoid oxygenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0673 | - | 1e-169 | 59.18% (490) | dioxygenase |
| M. gilvum PYR-GCK | Mflv_2111 | - | 0.0 | 77.75% (481) | carotenoid oxygenase |
| M. tuberculosis H37Rv | Rv0654 | - | 1e-169 | 59.18% (490) | dioxygenase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_3874c | - | 1e-160 | 54.81% (489) | putative dioxygenase |
| M. marinum M | MMAR_0993 | - | 1e-173 | 60.29% (486) | dioxygenase |
| M. avium 104 | MAV_0560 | - | 0.0 | 72.38% (478) | carotenoid oxygenase |
| M. smegmatis MC2 155 | MSMEG_6224 | - | 2e-89 | 39.20% (477) | retinal pigment epithelial membrane protein |
| M. thermoresistible (build 8) | TH_3959 | - | 0.0 | 76.99% (478) | PUTATIVE Carotenoid oxygenase |
| M. ulcerans Agy99 | MUL_0744 | - | 1e-170 | 59.67% (486) | dioxygenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0673|M.bovis_AF2122/97 ---MTTAQAAESQNPYLEGFLAPVSTEVTATDLPVTGRIPEHLDGRYLRN
Rv0654|M.tuberculosis_H37Rv ---MTTAQAAESQNPYLEGFLAPVSTEVTATDLPVTGRIPEHLDGRYLRN
MMAR_0993|M.marinum_M ---MTTMRSAQPRNPYLEGFLAPVRAEVTATDLEVTGRIPDYLDGRYLRN
MUL_0744|M.ulcerans_Agy99 ---MTTMRSAQPRNPYLEGFLAPVRAEVTATDLEVTGRIPDYLDGRYLRN
MAB_3874c|M.abscessus_ATCC_199 --MTATAQPAASTSPYLSGIWEPVQQEMDSVDLEVTGTLPAHLDGRYLRN
Mflv_2111|M.gilvum_PYR-GCK -----------MANRYLEGAFAPISEEHTLTDLDVIGTIPDHLDGRYLRN
TH_3959|M.thermoresistible__bu -----------VSNRYLTGAFAPLTEEYTLTDLEVTGTIPDYLDGRYLRN
Mvan_4595|M.vanbaalenii_PYR-1 -----------MGNQYLEGAFAPVANEYTLTGLDVVGDIPAYLDGRYLRN
MAV_0560|M.avium_104 -----------MANRYLQGPFAPMHHEYTLTGLEVVGTIPDYLDGRYLRN
MSMEG_6224|M.smegmatis_MC2_155 MTDTDLTNLPGTGEFFRRGNYAPVPDELTDYDLPVTGAIPPELDGWYLRN
. : * *: * .* * * :* *** ****
Mb0673|M.bovis_AF2122/97 GPNPVAEVDPATYHWFTGDAMVHGVALRDGKARWYRNRWVRTPAVCAALG
Rv0654|M.tuberculosis_H37Rv GPNPVAEVDPATYHWFTGDAMVHGVALRDGKARWYRNRWVRTPAVCAALG
MMAR_0993|M.marinum_M GPNPVAEVNPATYHWFTGDGMVHGVALRDGRASWYRNRWVRSMPVCAALG
MUL_0744|M.ulcerans_Agy99 GPNPVAEVNPATYHWFTGDGMVHGVALRDGRASWYRNRWVRSMPVCAALG
MAB_3874c|M.abscessus_ATCC_199 GPNPAAEVDPATYHLFSGDAMVHGLSLREGKAQWYRNRWVRTPSVSKTLG
Mflv_2111|M.gilvum_PYR-GCK GPNPIGDLDPALYHWFIGDGMVHGIRIRDGRAEWYRNRWVRGPAAARALG
TH_3959|M.thermoresistible__bu GPNPVGEIDPELYHWFVGDGMVHGIRLRDGRAEWYRNRWVRGPLTARALG
Mvan_4595|M.vanbaalenii_PYR-1 GPNPVAEVDPELYHWFTGDGMVHGIRIRDGKAEWYRNRWVRSPRVAEALG
MAV_0560|M.avium_104 GANPIGDVDPERYHWFLGDGMVHGIRIRDGKAEWYRNRWVRSPATSKALG
MSMEG_6224|M.smegmatis_MC2_155 GPNPR----QATAHWFTGDGMIHGVRIENGAAKWYRNRWVRTDSFIESFP
*.** * * **.*:**: :.:* * ******** ::
Mb0673|M.bovis_AF2122/97 EPISARPHPRTGIIEGGPNTNVLTHAGRTLALVEAGVVNYELTDELDTVG
Rv0654|M.tuberculosis_H37Rv EPISARPHPRTGIIEGGPNTNVLTHAGRTLALVEAGVVNYELTDELDTVG
MMAR_0993|M.marinum_M ESPPSRLDPRAGMLGLGANTNVLSHAGRTLALVEGGVANYELTDDLDTVG
MUL_0744|M.ulcerans_Agy99 ESPPARRDPRAGMLGLGANTNVLSHAGRTLALVEGGVANYELTDDLDTVG
MAB_3874c|M.abscessus_ATCC_199 ETRPAAISANAGMGVIGPNTNVLGHAGRTLALVEGGIANYELTEDLDTIG
Mflv_2111|M.gilvum_PYR-GCK ESVPDG---RFPISGIGANTNVIGHAGKTLALIEAGVPNYELTDDLDTVG
TH_3959|M.thermoresistible__bu ERPPSE---ECSVSGIGANTNVIGHAGKTIALVESGVTNYELTEELDTVG
Mvan_4595|M.vanbaalenii_PYR-1 ETPPRG---DYGLTPIGANTNVIGHAGKTLALIEAGVAQYELTDDLDAVD
MAV_0560|M.avium_104 QPAPPG---HFGFFPIGANTNVIGHAGKTLALIEGGIANYELTEELDTVG
MSMEG_6224|M.smegmatis_MC2_155 VYNADG---TRNLRASVANTHIVNHAGKTLALVESSLP-YEITGDLETVG
. . .**::: ***:*:**:*..: **:* :*:::.
Mb0673|M.bovis_AF2122/97 PCDFDGTLHGGYTAHPQRDPHTGELHAVSYSFARGHRVQYSVIGTDGHAR
Rv0654|M.tuberculosis_H37Rv PCDFDGTLHGGYTAHPQRDPHTGELHAVSYSFARGHRVQYSVIGTDGHAR
MMAR_0993|M.marinum_M TCDFDGTLPGGYTAHPHRDPQTGELHAVSYSFTRGHTVQYSVIDTQGRAR
MUL_0744|M.ulcerans_Agy99 TCDFDGTLPGGYTAHPHRDPQTGELHAVSYSFTRGHMVQYSVIDTQGRAR
MAB_3874c|M.abscessus_ATCC_199 TCDFDGTLPGGYTAHPHTDPDTGEMHAVSYSFARGSTVQYSVIDAHGRAR
Mflv_2111|M.gilvum_PYR-GCK TCDFDGTLSGGYTAHPKRDPDTGELHAVSYSMLRGNTVQYSVIDTGGRAR
TH_3959|M.thermoresistible__bu PCDFDGTLTGGYTAHPKRDPETGELHAVSYSMYRGNTVQYSVIGTDGRAR
Mvan_4595|M.vanbaalenii_PYR-1 VCDFDGTLAGGYTAHPKRDPGTGELHAVSYCLLNGNTVQYSVVGVDGRAR
MAV_0560|M.avium_104 VCDFAGTLTGGYAAHPHRDPETGELHAVSYNPYRGNRVQYSVIDVEGRAR
MSMEG_6224|M.smegmatis_MC2_155 AYDFGGKLVDSMTAHPKICPTTGEMHFFGYGSLFEPYVTYHRADADGELT
** *.* .. :***: * ***:* ..* * * .. *.
Mb0673|M.bovis_AF2122/97 RTVDIEVAGSPMMHSFSLTDNYVVIYDLPVTFDPMQVVP-ASVPRWLQRP
Rv0654|M.tuberculosis_H37Rv RTVDIEVAGSPMMHSFSLTDNYVVIYDLPVTFDPMQVVP-ASVPRWLQRP
MMAR_0993|M.marinum_M RTVDIEVTGSPMMHDFSLTDKYVVIYDLPVTFDSAQVMP-VKMPSWLGVP
MUL_0744|M.ulcerans_Agy99 RTVDIEVTGSPMMHDFSLTDKYVVIYDLPVTFDSAQVMP-VKMPSWLGVP
MAB_3874c|M.abscessus_ATCC_199 RTVDIPVHGAPMMHDFTLTEKYVVFYDLPVTLDMSMISQSVPVPRLLRKP
Mflv_2111|M.gilvum_PYR-GCK RTVDIEVAGSPMMHDFSLTERHVIFYDLPVTFDTRRAVE-MTVPRGLRLP
TH_3959|M.thermoresistible__bu RTVDIEVTGSPMMHDFSLTERHIVLYDLPVTFDARQAVS-MTVPRGLRLP
Mvan_4595|M.vanbaalenii_PYR-1 RTVDVEVTGSPMMHDFSLTERHVVFYDLPVTFDSRQAAT-IGVPRWLQLP
MAV_0560|M.avium_104 RTVDVTVGGSPMMHDFSLTERYVVFYDLPVTFDAAVGAA-MTAPRGLRPI
MSMEG_6224|M.smegmatis_MC2_155 INRPVDVKAHTMMHDFAMTSGHVIFMDLPVVFDLDIALK-----------
. : * . .***.*::*. :::: ****.:*
Mb0673|M.bovis_AF2122/97 ARLVIQSVLGRVRIPDPIAALGNRMQGHSDRLPYAWNPSYPARVGVMPRE
Rv0654|M.tuberculosis_H37Rv ARLVIQSVLGRVRIPDPIAALGNRMQGHSDRLPYAWNPSYPARVGVMPRE
MMAR_0993|M.marinum_M ARLVMASLIGNVRVPSPIAAMMNRNPKPSNRLPYAWNPAYPARIGVMPRE
MUL_0744|M.ulcerans_Agy99 ARLVMASLIGNVRVPSLIAAMLNRNPKPSNRLPYAWNPAYPARIGVMPRE
MAB_3874c|M.abscessus_ATCC_199 AQIVMNSLIGKVKIPGPIAAKASQYSGKSPSIPYSWNPKYPARIGVMPRE
Mflv_2111|M.gilvum_PYR-GCK ARLVLSALIGRVRIPDPVAARQPSGSGSDRRFPYSWNPRYPARIGVMPRD
TH_3959|M.thermoresistible__bu ARLVLSALIGRVRVPDPIAARQPRGNSSDRRFPYSWNPRYPARIGVMPRD
Mvan_4595|M.vanbaalenii_PYR-1 ARLVLSALIGRVRIPDPLAARRPGRDSSDAAFPYSWNPRYPARVGVMPRE
MAV_0560|M.avium_104 ARLMLSALIGRVAIPDPIAARLP-AATTDRRMPYSWNPNYPARVGVMPRD
MSMEG_6224|M.smegmatis_MC2_155 ---------------------------GTGDMPYRWSDTYGARFGLLRRD
:** *. * **.*:: *:
Mb0673|M.bovis_AF2122/97 GGNED----VRWFDIEPCYVYHPLNAYSECRNGAEVLVLDVVRYSRMFDR
Rv0654|M.tuberculosis_H37Rv GGNED----VRWFDIEPCYVYHPLNAYSECRNGAEVLVLDVVRYSRMFDR
MMAR_0993|M.marinum_M GGNRD----VRWFDIEPCYVYHPLNAYSEHRDGAEVLILDVVRYRRMFDR
MUL_0744|M.ulcerans_Agy99 GGNRD----VRWFDIEPCYVYHPLNAYSEHRDGAEVLILDVVRYRRMFDR
MAB_3874c|M.abscessus_ATCC_199 GDDASRHAPVRWFEIDPCYVFHPLNGYSEMRNGAEVIVIDLVRYDSMFSQ
Mflv_2111|M.gilvum_PYR-GCK GGSAD----VRWFDVEPCYVFHPMNAYDSP--ADDTIVLDVVRHPKMFDT
TH_3959|M.thermoresistible__bu GSNKD----VRWFDVEPCYVFHPMNAYDD----GDTIVLDVIRHPKMFDT
Mvan_4595|M.vanbaalenii_PYR-1 GGNGD----VRWFEVEPCYVFHPMNAFDD----GDTVVLDVVRHEKMFAT
MAV_0560|M.avium_104 GEDAD----VRWFDVEPCYVFHPMNAYEE----DGTIVLDVVRNPKMFDR
MSMEG_6224|M.smegmatis_MC2_155 DPFGE----IRWFDIDPCYIFHVVNAYEH----GNTVVVQAVRYPELWRD
. . :***:::***::* :*.:. .:::: :* ::
Mb0673|M.bovis_AF2122/97 DRRGPGGDSRPSLDRWTINLATGAVTAECRDDRAQEFPRINETLVGGPHR
Rv0654|M.tuberculosis_H37Rv DRRGPGGDSRPSLDRWTINLATGAVTAECRDDRAQEFPRINETLVGGPHR
MMAR_0993|M.marinum_M DRRGPG-DTTPSLDRWVINLTTGAVSTECRDDRSQEFPRINETLLGKRHR
MUL_0744|M.ulcerans_Agy99 DRRGPG-DTSPSLDRWVINLTTGAVSTECRDDRSQEFPRINETLLGKRHR
MAB_3874c|M.abscessus_ATCC_199 DVLGPS-DAKGQLDRWTIDLAKGTVHMERKDDRHLEFPRINETFTGKKHR
Mflv_2111|M.gilvum_PYR-GCK DHLGPN-EGPPTLERWTVDLVAGKVRESRVDDRAQEFPRVDERRVGKRHR
TH_3959|M.thermoresistible__bu DNLGPN-EGPPTLDRWTVDLADGKVRESRIDDRGQEFPRVDERLVGRRHR
Mvan_4595|M.vanbaalenii_PYR-1 DHLGPN-EGIPTLERWTVDLADGKVRESRIDDRGQEFPRVDERVVGRRHR
MAV_0560|M.avium_104 DRTGPN-EGPPTLDRWVIDLAAGKVRESRIDDRGQEFPRIDERLVGKRHR
MSMEG_6224|M.smegmatis_MC2_155 NG---SFDAQAVLWSWTIDLQTGAVTERQLDDLAVEFPRIDDRLAGLHAR
: . : * *.::* * * ** ****::: * *
Mb0673|M.bovis_AF2122/97 FAYTVGIEGGFLVGAGAALSTPLYKQDCVTGSSTVASLDPDLLIGEMVFV
Rv0654|M.tuberculosis_H37Rv FAYTVGIEGGFLVGAGAALSTPLYKQDCVTGSSTVASLDPDLLIGEMVFV
MMAR_0993|M.marinum_M FGYTLGVDGGYLTGGTSDMSTSLYKQDYATGSSQVAPLDSDLLLGEMAFV
MUL_0744|M.ulcerans_Agy99 FGYTLGVDGGYLTGGTSDMSTSLYKQDYATGSSQVAPLDPDLLLGEMAFV
MAB_3874c|M.abscessus_ATCC_199 YGYLPDVEN--FFGSGEAAGASIVKYDYETGSTLSSRLDPAIVLGEMSFV
Mflv_2111|M.gilvum_PYR-GCK YGYAP------CVGDGT-GDDELLKHDLVGGNSLTRAFGNGKVAGEFVFH
TH_3959|M.thermoresistible__bu YGYAP------TVGEGTSGGNVLLKHDFVGGNTQSRVFEPYHELGEFVFQ
Mvan_4595|M.vanbaalenii_PYR-1 YGYAP------TVTGGGSCADTLLKHDFVGTGSVARSFGAGKTLGEFVFH
MAV_0560|M.avium_104 YGYTP------TVLEGIEGGDCLLKHDLIGGSTQSRSLGPQKALGEFVFH
MSMEG_6224|M.smegmatis_MC2_155 YSVAAG-------------DHGWVRYDMTTGDAQRHDLGTG-GPGEAVFV
:. : * .: : ** *
Mb0673|M.bovis_AF2122/97 PNPSARAEDDGILMGYGWHRGRDEGQLLLLDAQTL--ESIATVHLPQRVP
Rv0654|M.tuberculosis_H37Rv PNPSARAEDDGILMGYGWHRGRDEGQLLLLDAQTL--ESIATVHLPQRVP
MMAR_0993|M.marinum_M PSPTAAAEDDGVLMGYGYHRGSDEGQLVLLDAQTL--ELAACVHLPQRVP
MUL_0744|M.ulcerans_Agy99 PSPTAAAEDHGVLMGYGYHRGSDEGQLVLLDAQTL--ELAACVHLPQRVP
MAB_3874c|M.abscessus_ATCC_199 PNPTCAAEDDGVLIGFAVDRRSDEGQLLLLDATSL--DLMATVHLPQRVP
Mflv_2111|M.gilvum_PYR-GCK PSSPDAAEDDGVLMGYVYDRTTDRSELAILDAATL--EDVATVKLPHRVP
TH_3959|M.thermoresistible__bu PSSADAAEDDGVVMGYVYDRTTDRSELAILDAQTL--EDVARIRLPHRVP
Mvan_4595|M.vanbaalenii_PYR-1 PSSPDAAEDDGVLMGYIYDRPTDRSQLAILDAATL--DDVAAVNLPHRVP
MAV_0560|M.avium_104 PSSPTAAEDEGVLMGYVYDRATNRSELAILDAQTL--EDVASIKLPHRVP
MSMEG_6224|M.smegmatis_MC2_155 PGAGPADESNGWYLGYVYDPERDGSDLVILDASDFGGKPVARIELPRRVP
*.. *..* :*: . : .:* :*** : . * :.**:***
Mb0673|M.bovis_AF2122/97 MGFHGNWAPTT-
Rv0654|M.tuberculosis_H37Rv MGFHGNWAPTT-
MMAR_0993|M.marinum_M LGFHGNWSAST-
MUL_0744|M.ulcerans_Agy99 LGFHGNWSAST-
MAB_3874c|M.abscessus_ATCC_199 AGFHGNWAPR--
Mflv_2111|M.gilvum_PYR-GCK SGFHGNWVPTA-
TH_3959|M.thermoresistible__bu AGFHGNWVPSDG
Mvan_4595|M.vanbaalenii_PYR-1 AGFHGNWVPTA-
MAV_0560|M.avium_104 AGFHGNWVPSTN
MSMEG_6224|M.smegmatis_MC2_155 YGFHGNWISA--
****** .