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MSEPPAPGRASPPTDRVVRVLDFLARHPQERFGVSELARRVDLTKPTCLGIVTSLRDAGYLVRDPADKTY RLGPSLITLGHKAQESMRVSPAAREQLRRLSTRFGATAALSAVVDDRITLLDLVAPVGARPGVEVGQSYP FAPPVGLMFVLWDDEAVRDWLAMEPTVPLHPSRTDPDRLHRVIRRCRADGYLVERLTPGGRRLYSLMAGM SSTLPDELRALLGELVSDIGERVYLPDEKPGRKRHDISVISAPVFDHYGRQVMVASMHIGKALTDNEIRE RAKALIGTADAVTAQLGGARPTSWPHTVGKGPDRDH
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_5230 | - | - | 100% (316) | regulatory proteins, IclR |
| M. vanbaalenii PYR-1 | Mvan_4894 | - | 2e-07 | 25.77% (163) | regulatory proteins, IclR |
| M. vanbaalenii PYR-1 | Mvan_4411 | - | 2e-06 | 28.72% (188) | regulatory proteins, IclR |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1748 | - | 2e-06 | 26.54% (211) | transcriptional regulatory protein |
| M. gilvum PYR-GCK | Mflv_1528 | - | 1e-139 | 81.73% (301) | regulatory protein, IclR |
| M. tuberculosis H37Rv | Rv1719 | - | 2e-06 | 26.54% (211) | transcriptional regulatory protein |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4180 | - | 1e-101 | 62.00% (300) | IclR family transcriptional regulator |
| M. marinum M | MMAR_3507 | - | 7e-23 | 25.96% (285) | IclR family transcriptional regulator |
| M. avium 104 | MAV_5235 | - | 7e-31 | 30.34% (290) | putative transcriptional regulator |
| M. smegmatis MC2 155 | MSMEG_5933 | - | 1e-116 | 68.75% (304) | hypothetical protein MSMEG_5933 |
| M. thermoresistible (build 8) | TH_0373 | - | 1e-117 | 70.96% (303) | conserved hypothetical protein |
| M. ulcerans Agy99 | MUL_2762 | - | 8e-23 | 26.06% (284) | IclR family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_5230|M.vanbaalenii_PYR-1 ---------------------------MSEPPA--PGRASPPTDRVVRVL
Mflv_1528|M.gilvum_PYR-GCK ---------------------------MSVPVQ--PGRASPPTDRVVQIL
TH_0373|M.thermoresistible__bu ---------------------------MVETGP--VGRTSPPTERVVQVL
MSMEG_5933|M.smegmatis_MC2_155 ---------------------------MLEQTD--AGRASPPTARVVAIL
MAB_4180|M.abscessus_ATCC_1997 ---------------------------MIEDRDNGAGRTSPPTERVMAVL
MMAR_3507|M.marinum_M ------------------------MTDTVDPASVSSQGSSPPTERVIAVL
MUL_2762|M.ulcerans_Agy99 MPSPPALASVEISTYRSIDIPFDILTGTVDPASVSSQGLSPPTERVIAVL
Mb1748|M.bovis_AF2122/97 ---------------------------MSAEEQDTRSGGIQVIARAAELL
Rv1719|M.tuberculosis_H37Rv ---------------------------MSAEEQDTRSGGIQVIARAAELL
MAV_5235|M.avium_104 ---------------------------------------------MLDVV
::
Mvan_5230|M.vanbaalenii_PYR-1 DFLARHPQERFGVSELARRVDLTKPTCLGIVTSLRDAGYLVR--DPADKT
Mflv_1528|M.gilvum_PYR-GCK DFLASRPTERYGVSDLARRVGLSKPTCLGIVTSLTEAGYLVR--DPADKT
TH_0373|M.thermoresistible__bu ELLARHPHERFGASEVARRLNLSKPTCLGILATLARHGYAVR--EPTDKT
MSMEG_5933|M.smegmatis_MC2_155 DFLARHPHDRFGLSELSRRVGVSKPTCLGILTTLTESGYLVREGDGRDKC
MAB_4180|M.abscessus_ATCC_1997 DFLAQHRTERFGLSELARRLGLSKPTCLGIVTTLAESGFLIR--DDRDKT
MMAR_3507|M.marinum_M ELLGHNSAKQFSLAEICRGLGISRATGHAILTTLAAREWVIR--DPETFR
MUL_2762|M.ulcerans_Agy99 ELLGHNSAKQFSLAEICRGLGISRATGHAILTTLAAREWVIR--DPETFR
Mb1748|M.bovis_AF2122/97 RVLQAHPGG-LSQAEIGERVGMARSTVSRILNALEDEGLVAS--RGARGP
Rv1719|M.tuberculosis_H37Rv RVLQAHPGG-LSQAEIGERVGMARSTVSRILNALEDEGLVAS--RGARGP
MAV_5235|M.avium_104 ELLARSPSARLRFSDVVRELGLTQATAHAILKTLCDRGWASR--DPVDKT
.* ::: . :.:::.* *: :*
Mvan_5230|M.vanbaalenii_PYR-1 YRLGPSLITLGHKAQESMRVSPAAREQLRRLSTRFGATAALSAVVDDRIT
Mflv_1528|M.gilvum_PYR-GCK YRLGPSLITLGHRAQESMRVSPAARDHLRRLSARYGATAALSAVVDDRIT
TH_0373|M.thermoresistible__bu YRPGPALIALGHAAQESLRVSPDARAQLRELSGAFGGTAALSAVVDDRIT
MSMEG_5933|M.smegmatis_MC2_155 YRLGPALIALGHMAQESMRVNPFARAELRALSGAFDSTAAISAVIDDRIT
MAB_4180|M.abscessus_ATCC_1997 YSLGPALIRIGRAAQESLRAKPASRDQLLALTREFGHTAALSAVVSDRVT
MMAR_3507|M.marinum_M YSWGPAIAGLDTPTTAQLHRG-----DLQELAAATGTQVMLARREDATLV
MUL_2762|M.ulcerans_Agy99 YSWGPAIAGLDTPTTAQLHRG-----DLQELAAATGTQVMLARREDATLV
Mb1748|M.bovis_AF2122/97 YRLGPEITRMATTVRLGVVTEMHP--FLTELSRELDETVDLSILDGDRAD
Rv1719|M.tuberculosis_H37Rv YRLGPEITRMATTVRLGVVTEMHP--FLTELSRELDETVDLSILDGDRAD
MAV_5235|M.avium_104 FALGPALAVVAARTDTARPLAHAARAAALRLSGAVGYACSVVEKFGDSLV
: ** : : . *: . : .
Mvan_5230|M.vanbaalenii_PYR-1 LLDLVAPVGARPGVEVGQSYPFAPPVGLMFVLWD-DEAVRDWLAMEPTVP
Mflv_1528|M.gilvum_PYR-GCK LLDLVAPTGARPGVEVGQSYPFAPPVGLMFVLWD-DEAEQDWLRRQPTIP
TH_0373|M.thermoresistible__bu VLELVAPPGATPPVHVGQSYPFAPPVGLMFVLWD-DEAVTAWLAKEPTIP
MSMEG_5933|M.smegmatis_MC2_155 VLELVAPPGTDVGVRVGQSYPFAPPVGLMYVLWD-DDALRAWLDKSPTVP
MAB_4180|M.abscessus_ATCC_1997 VLEVVSDPDHPVRVEVGQSYPFTPPVGLMFVLWDTDETITSWLAKDPTAP
MMAR_3507|M.marinum_M VIDTVGECPRGPRISRGMRTPFVAPIGRDYVAWWSPDAQQDWLRAFGAPN
MUL_2762|M.ulcerans_Agy99 VIDTVGECPRGPRISRGMRTPFVAPIGRDYVAWWSPDAQQDWLRAFGAPN
Mb1748|M.bovis_AF2122/97 VVDQVVPP---------QRLRAVSAVGESFPLYCCANGKALLAALPPERQ
Rv1719|M.tuberculosis_H37Rv VVDQVVPP---------QRLRAVSAVGESFPLYCCANGKALLAALPPERQ
MAV_5235|M.avium_104 VTAFEGEPATQPSGIPGDRIPYAPPFGVAMAAWDTEEEQRAWIQRGAGSN
: ....* : :
Mvan_5230|M.vanbaalenii_PYR-1 LHPSRTDPDRLHRVIRRCRADGYLVERLTPGGRRLYSLMAGMSST-LPDE
Mflv_1528|M.gilvum_PYR-GCK LR---TDTERLKRVVASCRADGYLVERQTPGGRRLYALMAGMPTE-LPDE
TH_0373|M.thermoresistible__bu LR---TDSERLQRVIAECRADGYLVERQTPAGQRLYTLMAGMSAT-LPEE
MSMEG_5933|M.smegmatis_MC2_155 LR---TDSERLEKVIGECRNSGYLVERLTPAGQRLYGLMAGMSSR-LPDE
MAB_4180|M.abscessus_ATCC_1997 GR---TADDRLRKVIEECRADGYLVELLTPAGRQLYSLMAGVPGD-IPNE
MMAR_3507|M.marinum_M PR----FLQRMTLVLNQIQRRGFVVERLTRQYVRVYTALRALSADGEVDE
MUL_2762|M.ulcerans_Agy99 PR----FLQRMILVLNQIQRRGFVVERLTRQYVRVYTALRALSADGEVDE
Mb1748|M.bovis_AF2122/97 AR-------------------------------ALPSRLAPLTANTITDR
Rv1719|M.tuberculosis_H37Rv AR-------------------------------ALPSRLAPLTANTITDR
MAV_5235|M.avium_104 ADR----AQRLRQVLEHTRERGFDVDWTTPALAQAVQVVGTLDSSEMPTP
: :
Mvan_5230|M.vanbaalenii_PYR-1 LRALLGELVSDIGERVYLPDEKP-----GRKRHDISVISAPVFDHYGRQV
Mflv_1528|M.gilvum_PYR-GCK LRALLGELVSDIGERVYLREESS-----GRRKHDISVISAPVFDHYQRQV
TH_0373|M.thermoresistible__bu LRALFGEMVSDIGERVYLRSEHSPA---GGAKFDISVISAPVFDRDHRQV
MSMEG_5933|M.smegmatis_MC2_155 LQALLRELVSDIGERVHLRSEAT-----GRQRHDVSVISAPVHDHHQRQV
MAB_4180|M.abscessus_ATCC_1997 LRALLGEIVSGIGERVYLRSENYTVGSGAKVRHRVNVISAPVYDHNGKQA
MMAR_3507|M.marinum_M ITTQLARAYADLAIIDVLDEELT-----SGATHSVATISAPIRGPDGSAT
MUL_2762|M.ulcerans_Agy99 ITTQLARAYADLAIIDVLDEELT-----SGATHSVATISAPIRGPDGSAT
Mb1748|M.bovis_AF2122/97 AALRDELNRIRVDGVAYDREEQT---------EGICAVGAVLRG-VSVEL
Rv1719|M.tuberculosis_H37Rv AALRDELNRIRVDGVAYDREEQT---------EGICAVGAVLRG-VSVEL
MAV_5235|M.avium_104 VRHIMDQLLVEFTTIGFLSDDNP-----GRRKQPVVTIAAPVFDHRGRAS
. .: : .:.* : .
Mvan_5230|M.vanbaalenii_PYR-1 MVASMHIGKALTDNEIRERAKALIGTADAVTAQLGGARPTSWPHTVGKGP
Mflv_1528|M.gilvum_PYR-GCK MVTSMHIGKALTDNEISERARAVVAAADAVTAQLGGMRP--------RDP
TH_0373|M.thermoresistible__bu MVTSLHVGDALSENEIRRRARAVVATADAVTRQLGGAKPR---WAGLTDP
MSMEG_5933|M.smegmatis_MC2_155 MVVSLHVGRALTDSEITKRARGVVAAADAVTAQLGGVKPTR---------
MAB_4180|M.abscessus_ATCC_1997 MVASLYIADDLTDAEITTRAKALVGTADGITEHIGGTKPF----------
MMAR_3507|M.marinum_M MTVMATVFANLDGAGIRKLGERLRRSAHAIEQRSARSSA-----------
MUL_2762|M.ulcerans_Agy99 MTVMATVFANLDGAGIRKLGERLRRSAHAIEQRSARSSA-----------
Mb1748|M.bovis_AF2122/97 VAVSVPVPAQRFYGREAELAGALLAWVSKVDAWFNGTEDRK---------
Rv1719|M.tuberculosis_H37Rv VAVSVPVPAQRFYGREAELAGALLAWVSKVDAWFNGTEDRK---------
MAV_5235|M.avium_104 LMVAVHPLCPLSARQIRVIGKHLTDETTALSRSRPASGAVDAAV------
: . . : . :
Mvan_5230|M.vanbaalenii_PYR-1 DRDH-
Mflv_1528|M.gilvum_PYR-GCK D----
TH_0373|M.thermoresistible__bu GRRVR
MSMEG_5933|M.smegmatis_MC2_155 -----
MAB_4180|M.abscessus_ATCC_1997 -----
MMAR_3507|M.marinum_M -----
MUL_2762|M.ulcerans_Agy99 -----
Mb1748|M.bovis_AF2122/97 -----
Rv1719|M.tuberculosis_H37Rv -----
MAV_5235|M.avium_104 -----