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LDVVELLARSPSARLRFSDVVRELGLTQATAHAILKTLCDRGWASRDPVDKTFALGPALAVVAARTDTAR PLAHAARAAALRLSGAVGYACSVVEKFGDSLVVTAFEGEPATQPSGIPGDRIPYAPPFGVAMAAWDTEEE QRAWIQRGAGSNADRAQRLRQVLEHTRERGFDVDWTTPALAQAVQVVGTLDSSEMPTPVRHIMDQLLVEF TTIGFLSDDNPGRRKQPVVTIAAPVFDHRGRASLMVAVHPLCPLSARQIRVIGKHLTDETTALSRSRPAS GAVDAAV*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_5235 | - | - | 100% (288) | putative transcriptional regulator |
| M. avium 104 | MAV_3545 | - | 3e-19 | 27.27% (297) | hypothetical protein MAV_3545 |
| M. avium 104 | MAV_5001 | - | 8e-12 | 24.34% (267) | hypothetical protein MAV_5001 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | - | - | - | - | - |
| M. gilvum PYR-GCK | Mflv_1528 | - | 4e-31 | 29.27% (287) | regulatory protein, IclR |
| M. tuberculosis H37Rv | - | - | - | - | - |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4180 | - | 2e-25 | 26.91% (275) | IclR family transcriptional regulator |
| M. marinum M | MMAR_3507 | - | 3e-23 | 28.67% (286) | IclR family transcriptional regulator |
| M. smegmatis MC2 155 | MSMEG_5933 | - | 3e-25 | 28.03% (289) | hypothetical protein MSMEG_5933 |
| M. thermoresistible (build 8) | TH_0373 | - | 1e-27 | 30.47% (279) | conserved hypothetical protein |
| M. ulcerans Agy99 | MUL_2762 | - | 4e-23 | 28.67% (286) | IclR family transcriptional regulator |
| M. vanbaalenii PYR-1 | Mvan_5230 | - | 7e-31 | 30.34% (290) | regulatory proteins, IclR |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_5933|M.smegmatis_MC2_155 ---------------------------MLEQTD--AGRASPPTARVVAIL
TH_0373|M.thermoresistible__bu ---------------------------MVETGP--VGRTSPPTERVVQVL
Mflv_1528|M.gilvum_PYR-GCK ---------------------------MSVPVQ--PGRASPPTDRVVQIL
Mvan_5230|M.vanbaalenii_PYR-1 ---------------------------MSEPPA--PGRASPPTDRVVRVL
MAB_4180|M.abscessus_ATCC_1997 ---------------------------MIEDRDNGAGRTSPPTERVMAVL
MMAR_3507|M.marinum_M ------------------------MTDTVDPASVSSQGSSPPTERVIAVL
MUL_2762|M.ulcerans_Agy99 MPSPPALASVEISTYRSIDIPFDILTGTVDPASVSSQGLSPPTERVIAVL
MAV_5235|M.avium_104 ---------------------------------------------MLDVV
:: ::
MSMEG_5933|M.smegmatis_MC2_155 DFLARHPHDRFGLSELSRRVGVSKPTCLGILTTLTESGYLVREGDGRDKC
TH_0373|M.thermoresistible__bu ELLARHPHERFGASEVARRLNLSKPTCLGILATLARHGYAVREP--TDKT
Mflv_1528|M.gilvum_PYR-GCK DFLASRPTERYGVSDLARRVGLSKPTCLGIVTSLTEAGYLVRDP--ADKT
Mvan_5230|M.vanbaalenii_PYR-1 DFLARHPQERFGVSELARRVDLTKPTCLGIVTSLRDAGYLVRDP--ADKT
MAB_4180|M.abscessus_ATCC_1997 DFLAQHRTERFGLSELARRLGLSKPTCLGIVTTLAESGFLIRDD--RDKT
MMAR_3507|M.marinum_M ELLGHNSAKQFSLAEICRGLGISRATGHAILTTLAAREWVIRDP--ETFR
MUL_2762|M.ulcerans_Agy99 ELLGHNSAKQFSLAEICRGLGISRATGHAILTTLAAREWVIRDP--ETFR
MAV_5235|M.avium_104 ELLARSPSARLRFSDVVRELGLTQATAHAILKTLCDRGWASRDP--VDKT
::*. : ::: * :.:::.* .*: :* : *:
MSMEG_5933|M.smegmatis_MC2_155 YRLGPALIALGHMAQESMRVNPFARAELRALSGAFDSTAAISAVIDDRIT
TH_0373|M.thermoresistible__bu YRPGPALIALGHAAQESLRVSPDARAQLRELSGAFGGTAALSAVVDDRIT
Mflv_1528|M.gilvum_PYR-GCK YRLGPSLITLGHRAQESMRVSPAARDHLRRLSARYGATAALSAVVDDRIT
Mvan_5230|M.vanbaalenii_PYR-1 YRLGPSLITLGHKAQESMRVSPAAREQLRRLSTRFGATAALSAVVDDRIT
MAB_4180|M.abscessus_ATCC_1997 YSLGPALIRIGRAAQESLRAKPASRDQLLALTREFGHTAALSAVVSDRVT
MMAR_3507|M.marinum_M YSWGPAIAGLDTPTTAQLHRG-----DLQELAAATGTQVMLARREDATLV
MUL_2762|M.ulcerans_Agy99 YSWGPAIAGLDTPTTAQLHRG-----DLQELAAATGTQVMLARREDATLV
MAV_5235|M.avium_104 FALGPALAVVAARTDTARPLAHAARAAALRLSGAVGYACSVVEKFGDSLV
: **:: : : *: . : . :.
MSMEG_5933|M.smegmatis_MC2_155 VLELVAPPGTDVGVRVGQSYPFAPPVGLMYVLWD-DDALRAWLDKSPTVP
TH_0373|M.thermoresistible__bu VLELVAPPGATPPVHVGQSYPFAPPVGLMFVLWD-DEAVTAWLAKEPTIP
Mflv_1528|M.gilvum_PYR-GCK LLDLVAPTGARPGVEVGQSYPFAPPVGLMFVLWD-DEAEQDWLRRQPTIP
Mvan_5230|M.vanbaalenii_PYR-1 LLDLVAPVGARPGVEVGQSYPFAPPVGLMFVLWD-DEAVRDWLAMEPTVP
MAB_4180|M.abscessus_ATCC_1997 VLEVVSDPDHPVRVEVGQSYPFTPPVGLMFVLWDTDETITSWLAKDPTAP
MMAR_3507|M.marinum_M VIDTVGECPRGPRISRGMRTPFVAPIGRDYVAWWSPDAQQDWLRAFGAPN
MUL_2762|M.ulcerans_Agy99 VIDTVGECPRGPRISRGMRTPFVAPIGRDYVAWWSPDAQQDWLRAFGAPN
MAV_5235|M.avium_104 VTAFEGEPATQPSGIPGDRIPYAPPFGVAMAAWDTEEEQRAWIQRGAGSN
: . * *:..*.* . * : *:
MSMEG_5933|M.smegmatis_MC2_155 LR---TDSERLEKVIGECRNSGYLVERLTPAGQRLYGLMAGMSSR-LPDE
TH_0373|M.thermoresistible__bu LR---TDSERLQRVIAECRADGYLVERQTPAGQRLYTLMAGMSAT-LPEE
Mflv_1528|M.gilvum_PYR-GCK LR---TDTERLKRVVASCRADGYLVERQTPGGRRLYALMAGMPTE-LPDE
Mvan_5230|M.vanbaalenii_PYR-1 LHPSRTDPDRLHRVIRRCRADGYLVERLTPGGRRLYSLMAGMSST-LPDE
MAB_4180|M.abscessus_ATCC_1997 GR---TADDRLRKVIEECRADGYLVELLTPAGRQLYSLMAGVPGD-IPNE
MMAR_3507|M.marinum_M PR----FLQRMTLVLNQIQRRGFVVERLTRQYVRVYTALRALSADGEVDE
MUL_2762|M.ulcerans_Agy99 PR----FLQRMILVLNQIQRRGFVVERLTRQYVRVYTALRALSADGEVDE
MAV_5235|M.avium_104 AD----RAQRLRQVLEHTRERGFDVDWTTPALAQAVQVVGTLDSSEMPTP
:*: *: : *: *: * : : :
MSMEG_5933|M.smegmatis_MC2_155 LQALLRELVSDIGERVHLRSEAT-----GRQRHDVSVISAPVHDHHQRQV
TH_0373|M.thermoresistible__bu LRALFGEMVSDIGERVYLRSEHSPA---GGAKFDISVISAPVFDRDHRQV
Mflv_1528|M.gilvum_PYR-GCK LRALLGELVSDIGERVYLREESS-----GRRKHDISVISAPVFDHYQRQV
Mvan_5230|M.vanbaalenii_PYR-1 LRALLGELVSDIGERVYLPDEKP-----GRKRHDISVISAPVFDHYGRQV
MAB_4180|M.abscessus_ATCC_1997 LRALLGEIVSGIGERVYLRSENYTVGSGAKVRHRVNVISAPVYDHNGKQA
MMAR_3507|M.marinum_M ITTQLARAYADLAIIDVLDEELT-----SGATHSVATISAPIRGPDGSAT
MUL_2762|M.ulcerans_Agy99 ITTQLARAYADLAIIDVLDEELT-----SGATHSVATISAPIRGPDGSAT
MAV_5235|M.avium_104 VRHIMDQLLVEFTTIGFLSDDNP-----GRRKQPVVTIAAPVFDHRGRAS
: : . : * .: . : .*:**: .
MSMEG_5933|M.smegmatis_MC2_155 MVVSLHVGRALTDSEITKRARGVVAAADAVTAQLGGVKPTR---------
TH_0373|M.thermoresistible__bu MVTSLHVGDALSENEIRRRARAVVATADAVTRQLGGAKPRWAGLTDPGRR
Mflv_1528|M.gilvum_PYR-GCK MVTSMHIGKALTDNEISERARAVVAAADAVTAQLGGMRP--------RDP
Mvan_5230|M.vanbaalenii_PYR-1 MVASMHIGKALTDNEIRERAKALIGTADAVTAQLGGARPTSWPHTVGKGP
MAB_4180|M.abscessus_ATCC_1997 MVASLYIADDLTDAEITTRAKALVGTADGITEHIGGTKPF----------
MMAR_3507|M.marinum_M MTVMATVFANLDGAGIRKLGERLRRSAHAIEQRSARSSA-----------
MUL_2762|M.ulcerans_Agy99 MTVMATVFANLDGAGIRKLGERLRRSAHAIEQRSARSSA-----------
MAV_5235|M.avium_104 LMVAVHPLCPLSARQIRVIGKHLTDETTALSRSRPASGAVDAAV------
: . * * .. : : .: .
MSMEG_5933|M.smegmatis_MC2_155 ----
TH_0373|M.thermoresistible__bu VR--
Mflv_1528|M.gilvum_PYR-GCK D---
Mvan_5230|M.vanbaalenii_PYR-1 DRDH
MAB_4180|M.abscessus_ATCC_1997 ----
MMAR_3507|M.marinum_M ----
MUL_2762|M.ulcerans_Agy99 ----
MAV_5235|M.avium_104 ----