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AFGLLRDKVVVISGVGPALGTTLARRCAEEGADLVLAARTVERLDDVARQITDLGRRAVSVGTDITDEAQ VNNLVDESLKAYGKVDVLINNAFRVPSMKPFADTTFEHMRDAIELTVFGALRMVQAFSPALAEANGAVVN VNSMVVRHSQAKYGAYKMAKSALLAMSQTLATELGEQGIRVNSVLPGYIWGGTLESYFTHQAGKYGTTVE EIYKATAAASDLKRLPTEDEVASAILFMASDLSSGITGQALDVNCGEFKA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_5228 | - | - | 100% (261) | short chain dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_4921 | - | 4e-28 | 32.81% (256) | short chain dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_1624 | - | 1e-24 | 28.85% (253) | short-chain dehydrogenase/reductase SDR |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3560c | - | 1e-114 | 77.73% (256) | short chain dehydrogenase |
| M. gilvum PYR-GCK | Mflv_1530 | - | 1e-134 | 94.23% (260) | short chain dehydrogenase |
| M. tuberculosis H37Rv | Rv3530c | - | 1e-114 | 77.73% (256) | short chain dehydrogenase |
| M. leprae Br4923 | MLBr_00862 | ephD | 2e-15 | 27.08% (192) | short chain dehydrogenase |
| M. abscessus ATCC 19977 | MAB_4178c | - | 4e-96 | 66.80% (253) | short chain dehydrogenase |
| M. marinum M | MMAR_5018 | - | 1e-109 | 75.39% (256) | short-chain alcohol dehydrogenase |
| M. avium 104 | MAV_0630 | - | 1e-108 | 75.29% (255) | short chain dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_5931 | - | 1e-128 | 87.60% (258) | short chain dehydrogenase |
| M. thermoresistible (build 8) | TH_3268 | - | 1e-114 | 81.18% (255) | PUTATIVE short-chain dehydrogenase/reductase SDR |
| M. ulcerans Agy99 | MUL_4092 | - | 1e-102 | 74.18% (244) | short chain dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_5228|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_1530|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_5931|M.smegmatis_MC2_155 --------------------------------------------------
TH_3268|M.thermoresistible__bu --------------------------------------------------
Mb3560c|M.bovis_AF2122/97 --------------------------------------------------
Rv3530c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_5018|M.marinum_M --------------------------------------------------
MUL_4092|M.ulcerans_Agy99 --------------------------------------------------
MAV_0630|M.avium_104 --------------------------------------------------
MAB_4178c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 MPATQSIHKVPHQFVESPDGVRLAIYQSGQPEGPAIVLVHGFPDSHVLWD
Mvan_5228|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_1530|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_5931|M.smegmatis_MC2_155 --------------------------------------------------
TH_3268|M.thermoresistible__bu --------------------------------------------------
Mb3560c|M.bovis_AF2122/97 --------------------------------------------------
Rv3530c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_5018|M.marinum_M --------------------------------------------------
MUL_4092|M.ulcerans_Agy99 --------------------------------------------------
MAV_0630|M.avium_104 --------------------------------------------------
MAB_4178c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 GVVPLLAKRFRIVRYDNRGVGQSSVPKPVSAYTMTRFADDFAAVIDELSP
Mvan_5228|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_1530|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_5931|M.smegmatis_MC2_155 --------------------------------------------------
TH_3268|M.thermoresistible__bu --------------------------------------------------
Mb3560c|M.bovis_AF2122/97 --------------------------------------------------
Rv3530c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_5018|M.marinum_M --------------------------------------------------
MUL_4092|M.ulcerans_Agy99 --------------------------------------------------
MAV_0630|M.avium_104 --------------------------------------------------
MAB_4178c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 DRPVHVLAHDWGSVGVWEYLSRSGASDRVASFTSVSGPSQDQLVDYILSG
Mvan_5228|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_1530|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_5931|M.smegmatis_MC2_155 --------------------------------------------------
TH_3268|M.thermoresistible__bu --------------------------------------------------
Mb3560c|M.bovis_AF2122/97 --------------------------------------------------
Rv3530c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_5018|M.marinum_M --------------------------------------------------
MUL_4092|M.ulcerans_Agy99 --------------------------------------------------
MAV_0630|M.avium_104 --------------------------------------------------
MAB_4178c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 LRRPWRPRTFARAVSQLFRLTYMVLFSIPVLVPMVLWIALSSATIRRTMV
Mvan_5228|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_1530|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_5931|M.smegmatis_MC2_155 --------------------------------------------------
TH_3268|M.thermoresistible__bu --------------------------------------------------
Mb3560c|M.bovis_AF2122/97 --------------------------------------------------
Rv3530c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_5018|M.marinum_M --------------------------------------------------
MUL_4092|M.ulcerans_Agy99 --------------------------------------------------
MAV_0630|M.avium_104 --------------------------------------------------
MAB_4178c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 DNISTDQIHHSATLARDAAHSVKTYPANYFRAFSGRRRGKGVPVVNVPVQ
Mvan_5228|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_1530|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_5931|M.smegmatis_MC2_155 --------------------------------------------------
TH_3268|M.thermoresistible__bu --------------------------------------------------
Mb3560c|M.bovis_AF2122/97 --------------------------------------------------
Rv3530c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_5018|M.marinum_M --------------------------------------------------
MUL_4092|M.ulcerans_Agy99 --------------------------------------------------
MAV_0630|M.avium_104 --------------------------------------------------
MAB_4178c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 LIVNTMDRYVRPYGYDATARWVPRLWRRDIKAGHFSPMSHPQVMAAAVHD
Mvan_5228|M.vanbaalenii_PYR-1 --------------------MAFGLLRDKVVVISGVGPALGTTLARRCAE
Mflv_1530|M.gilvum_PYR-GCK ------------------MSEALPLLENKVVVISGVGPALGTTLARRCAE
MSMEG_5931|M.smegmatis_MC2_155 ---------------------MGGLLTDKVVVISGVGPALGTTLARRCAE
TH_3268|M.thermoresistible__bu --------------------MTMLSLDNKVVVISGVGPALGTTLARRCAA
Mb3560c|M.bovis_AF2122/97 ---------------------MTGMLKRKVIVVSGVGPGLGTTLAHRCAR
Rv3530c|M.tuberculosis_H37Rv ---------------------MTGMLKRKVIVVSGVGPGLGTTLAHRCAR
MMAR_5018|M.marinum_M ---------------------MPGLLDGKTLVISGVGPGLGTTLAHRCAA
MUL_4092|M.ulcerans_Agy99 -----------------------------------MGPGLGTTLAHRCAA
MAV_0630|M.avium_104 ------------------------MLDGKVVVISGVGPGLGTTLAHRCAD
MAB_4178c|M.abscessus_ATCC_199 --------------------MSLLNFDGKVVVVSGIGPGLGAALAIKFAE
MLBr_00862|M.leprae_Br4923 LADLVDGKQPSRALLRAQVGRSRDTFGDTLVSVTGAGSGIGRETALALAR
*..:* * *
Mvan_5228|M.vanbaalenii_PYR-1 EGADLVLAARTVERLDDVARQITDLGRRAVSVGTDITDEAQVNNLVDESL
Mflv_1530|M.gilvum_PYR-GCK AGADLVLAARTVERLEDVATQITDLGRRAVSVGTDITDEAQVANLVEESL
MSMEG_5931|M.smegmatis_MC2_155 QGADLVLAARTVERLEDVAKQVTDTGRRALSVGTDITDDAQVAHLVDETM
TH_3268|M.thermoresistible__bu AGADLVLAARTAERLEEVAGQITATGRRAVAVPTDITDEAQVANLVAETN
Mb3560c|M.bovis_AF2122/97 DGADLVLAARSAERLDDVAKQIIDTGRRAVAVRTDITDDDDVSNLVQATL
Rv3530c|M.tuberculosis_H37Rv DGADLVLAARSAERLDDVAKQIIDTGRRAVAVRTDITDDDDVSNLVQATL
MMAR_5018|M.marinum_M EGADLVLAARSGDRLDELAKQIIDKGRQAIAVRADITDDDQVSNLVDATL
MUL_4092|M.ulcerans_Agy99 EGADLVLAARIGDRLDELAKQIIDKGRQAIAVRADITDDDQVSNLVDATL
MAV_0630|M.avium_104 SGADLVLAARTAERLEKVAKQVNDGGHRALAVRTDITDDDEVAYLVETTM
MAB_4178c|M.abscessus_ATCC_199 AGADVVLAARTQSRLDEVARQIAATGRRALAVATDITDEASAANLVERAT
MLBr_00862|M.leprae_Br4923 RGAEVVVSDIDEAAAKNTAAQIVASGGVAYAYALDVSDAAAVEAFAEQVS
**::*:: .. * *: * * : *::* . :.
Mvan_5228|M.vanbaalenii_PYR-1 KAYGKVDVLINNAFRVPSMKPFADTTFEHMRDAIELTVFGALRMVQAFSP
Mflv_1530|M.gilvum_PYR-GCK KAYGKVDVLINNAFRVPSMKPFANTTFEHMRDAIELTVFGALRMVQAFTP
MSMEG_5931|M.smegmatis_MC2_155 KAYGRVDVVINNAFRVPSMKPFANTTFEHMRDAIELTVFGALRLIQGFTP
TH_3268|M.thermoresistible__bu KAYGRVDVLINNAFRVPSMKPLANTGFDHIREAIELTVLGALRLTQALTP
Mb3560c|M.bovis_AF2122/97 AAYGKADVLINNAFRVPSMKPLAGTTFEHIRDAIELSALGTLRLIQAFTP
Rv3530c|M.tuberculosis_H37Rv AAYGKADVLINNAFRVPSMKPLAGTTFEHIRDAIELSALGTLRLIQAFTP
MMAR_5018|M.marinum_M EAYGKIDVLVNNAFRVPSMKPLAETTFQHIRDAIELSALGALRVIAGFTR
MUL_4092|M.ulcerans_Agy99 EAYGKIDVLVNNAFRVPSMKPLAETTFQHIRDAIELSALGALRVIAGFTR
MAV_0630|M.avium_104 ATYGRADVLINNAFRVPSMKPLAGTSFQHIRDAIELSALGALRLIQAFTP
MAB_4178c|M.abscessus_ATCC_199 EEFGGIDVLVNNAFSIPSMKSLEKTDYQHIRDSVELTVVGTLRLTQRVAA
MLBr_00862|M.leprae_Br4923 AKHGVPDIVVNNAG-IGQAGRFLDTPPEEFDRVLAVNLGGVVNCCRAFGQ
.* *:::*** : . : * :.: : :. *.:. .
Mvan_5228|M.vanbaalenii_PYR-1 ALAE--ANGAVVNVNSMVVRHSQAKYGAYKMAKSALLAMSQTLATELGEQ
Mflv_1530|M.gilvum_PYR-GCK ALAE--ANGAVVNVNSMVVRHSQAKYGAYKMAKSALLAMSQTLATELGDQ
MSMEG_5931|M.smegmatis_MC2_155 ALEE--SKGAVVNVNSMVVRHSQAKYGAYKMAKSALLAMSQTLATELGEK
TH_3268|M.thermoresistible__bu ALAQ--ANGSVVNVNSMVIRHSQPKYGAYKMAKAALLAMSQSLASELGEQ
Mb3560c|M.bovis_AF2122/97 ALAQ--SHGAIVNVNSMVIRHSQPKYGTYKMAKSVLLAMSHSLATELGEQ
Rv3530c|M.tuberculosis_H37Rv ALAQ--SHGAIVNVNSMVIRHSQPKYGTYKMAKSVLLAMSHSLATELGEQ
MMAR_5018|M.marinum_M ALAE--TNGSIVNVNSMVLRHSQPKFGAYKMAKSTLLAMSHSLAAELGVK
MUL_4092|M.ulcerans_Agy99 ALAE--TNGSIVNVNSMVLRHSQPKFGADKTAKSTLLAMSHSLAAELGVK
MAV_0630|M.avium_104 ALET--AHGSIVNVNSMVLRHSQAKYGAYKMAKSALLSMSQSLATELGEK
MAB_4178c|M.abscessus_ATCC_199 ALAQ--SKGAVVNINSMVIRHSQVRYGSYKIAKAALLAMSQSLATELGPQ
MLBr_00862|M.leprae_Br4923 RLVERGTGGHIVNVSSMAAYAPLQSLSAYCTSKAATYMFSDCLRAELDAV
* : * :**:.**. . .: :*:. :*. * :**.
Mvan_5228|M.vanbaalenii_PYR-1 GIRVNSVLPGYIWGGTLESYFTHQAGKYGTTVEEIYKATAAASDLKRLPT
Mflv_1530|M.gilvum_PYR-GCK GIRVNSVLPGYIWGGTLESYFSHQAGKYGTTVDEIYKATAAASDLKRLPT
MSMEG_5931|M.smegmatis_MC2_155 GIRVNSVLPGYIWGGTLKSYFEHQAGKYGTSVEDIYNAAAAGSDLKRLPT
TH_3268|M.thermoresistible__bu GIRVNSVVPGYIWGETLKGYFQHQAGKYNTTVDQIYQATAAQSDLKRLPT
Mb3560c|M.bovis_AF2122/97 GIRVNSVAPGYIWGDTLKSYFDHQAGKYGTTVDQIYQATAANSDLKRLPT
Rv3530c|M.tuberculosis_H37Rv GIRVNSVAPGYIWGDTLKSYFDHQAGKYGTTVDQIYQATAANSDLKRLPT
MMAR_5018|M.marinum_M GIRVNSVAPGYIWGDTLQGYFEHQAGKYGTTVEQIYQATAAQSDLKRLPT
MUL_4092|M.ulcerans_Agy99 GIWVNSVAPGYIWGDTLQGYFEHQAGKYGTTVEKIYQATAAQSDLKRLPT
MAV_0630|M.avium_104 GIRVNSVAPGYIWGDTLQAYFEHQAGKYGTTVEQIYAATAANSDLKRLPT
MAB_4178c|M.abscessus_ATCC_199 GVRVNSVVPGYMWGENLKGYFEHQAKKYGGTVEQIYEYTAANSDLKRLPT
MLBr_00862|M.leprae_Br4923 GVGLTTICPGVIDTNIIQSTRIDTPTAKQERVRDRRGQLDMMFRLRRYGP
*: :.:: ** : ::. . . * . *:* .
Mvan_5228|M.vanbaalenii_PYR-1 EDEVASAILFMASDLSSGITGQALDVNCGEFKA--------------
Mflv_1530|M.gilvum_PYR-GCK EDEVASAILFMACDLSSGITGQALDVNCGEFKA--------------
MSMEG_5931|M.smegmatis_MC2_155 EDEVASAILFMASDLASGITGQALDVNCGEYKA--------------
TH_3268|M.thermoresistible__bu EDEVASAILFFASDLSSGITGQTLDVNCGEYKV--------------
Mb3560c|M.bovis_AF2122/97 EDEVASAILFLASDLASGITGQTLDVNCGEYHT--------------
Rv3530c|M.tuberculosis_H37Rv EDEVASAILFLASDLASGITGQTLDVNCGEYHT--------------
MMAR_5018|M.marinum_M EDEVASAILFMASDLSSGITGQTLDVNCGEYHT--------------
MUL_4092|M.ulcerans_Agy99 EDEVASAVLFMASDLSSGITGQTLDVNCGEYHT--------------
MAV_0630|M.avium_104 EDEVASAIMFLASDLSSGITGQTLDVNCGEYHT--------------
MAB_4178c|M.abscessus_ATCC_199 TDEVANAVLFLASDLASGITGQALDVNCGEFHA--------------
MLBr_00862|M.leprae_Br4923 DKVADTILSAIKKNKPIRPVAPEAYALYGISRVLPQVLRSTARIRVI
. . . : : : . .. . * :.