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MTMTISTPADRETATADSDPELAARFEREALPLRDVLLRGARRLTTNEADAEDLLQDTLLAAYKGFRTFT PGTNIQAWLFRIMQNRWINNFRRKQRRVDEVTMDGITEGALAAGTRRAPAAPHSVEAELFGGIADDDVTA ALGALPEGYRLVLYYAEVEGYTYAETAAILSIPPGTVMSRVYRARQRLRIALAHKAVGRGAELDDEIAA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_5003 | - | - | 100% (209) | ECF subfamily RNA polymerase sigma-24 factor |
| M. vanbaalenii PYR-1 | Mvan_1778 | - | 1e-46 | 46.94% (196) | ECF subfamily RNA polymerase sigma-24 factor |
| M. vanbaalenii PYR-1 | Mvan_2297 | - | 5e-44 | 50.54% (186) | ECF subfamily RNA polymerase sigma-24 factor |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3250c | sigH | 2e-46 | 48.91% (184) | RNA polymerase sigma factor RpoE |
| M. gilvum PYR-GCK | Mflv_4689 | - | 2e-48 | 47.52% (202) | ECF subfamily RNA polymerase sigma-24 factor |
| M. tuberculosis H37Rv | Rv3223c | sigH | 2e-46 | 48.91% (184) | RNA polymerase sigma factor RpoE |
| M. leprae Br4923 | MLBr_01076 | sigE | 1e-18 | 34.76% (164) | RNA polymerase sigma factor SigE |
| M. abscessus ATCC 19977 | MAB_3543c | - | 9e-46 | 46.88% (192) | RNA polymerase sigma-E factor |
| M. marinum M | MMAR_1334 | sigH | 8e-47 | 48.91% (184) | alternative RNA polymerase sigma-E factor (sigma- 24) SigH |
| M. avium 104 | MAV_4171 | - | 1e-47 | 48.19% (193) | RNA polymerase sigma factor RpoE |
| M. smegmatis MC2 155 | MSMEG_1690 | - | 3e-52 | 54.64% (194) | putative ECF sigma factor RpoE1 |
| M. thermoresistible (build 8) | TH_4436 | - | 3e-46 | 52.63% (190) | PUTATIVE RNA polymerase, sigma-24 subunit, ECF subfamily |
| M. ulcerans Agy99 | MUL_2545 | sigH | 5e-46 | 48.37% (184) | RNA polymerase sigma factor RpoE |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3250c|M.bovis_AF2122/97 ----------------------------------------MAD----IDG
Rv3223c|M.tuberculosis_H37Rv ----------------------------------------MAD----IDG
MMAR_1334|M.marinum_M -MSTSTSLLGEERLGRFPASPASVATLSGGTSTEGTVFIKMAD----IDG
MUL_2545|M.ulcerans_Agy99 ----------------------------------------MAD----IDG
MAV_4171|M.avium_104 MVSTATSLLGEEQLAGFLASPGALSVLSGDTAAEGTGFIEMADSPDGPDG
Mflv_4689|M.gilvum_PYR-GCK -------MVPVMAMKAPSRSVFVLDVIGG-AATEGTVFPTMTD----TNG
MAB_3543c|M.abscessus_ATCC_199 --------------MACLERPMSVPIRMVGVATERTAVTSMDS-------
TH_4436|M.thermoresistible__bu --------------------------------------------------
MSMEG_1690|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_5003|M.vanbaalenii_PYR-1 -------------------------------------------------M
MLBr_01076|M.leprae_Br4923 -MGDGIGMEREGRWTGNTQCPLRVVPGDESPTLDGRASPEDLIITNLLSP
Mb3250c|M.bovis_AF2122/97 VTGSAGLQP--------GPSEETDEELTARFERDAIPLLDQLYGG-----
Rv3223c|M.tuberculosis_H37Rv VTGSAGLQP--------GPSEETDEELTARFERDAIPLLDQLYGG-----
MMAR_1334|M.marinum_M VTLAEAPDP--------EPPEETDEQLTARFERDAIPLLDQLYGG-----
MUL_2545|M.ulcerans_Agy99 VTLAEAPDP--------EPPEETDEQLTACFERDAIPLLDQLYGG-----
MAV_4171|M.avium_104 VTSPEVPEAHAEPAAHEETREETDAELTARFERDAIPLLDQLYGG-----
Mflv_4689|M.gilvum_PYR-GCK LAASPAPADAG------EAREETDAELTARFERDAIPLLDQLYGG-----
MAB_3543c|M.abscessus_ATCC_199 --AAELPGL---------VHVETEAERVARFERDALPLLDQLYGA-----
TH_4436|M.thermoresistible__bu -MTASIPSA----------RIQPDSALKARFAAEVGPLIDVLSRG-----
MSMEG_1690|M.smegmatis_MC2_155 --MTLPPDL---------DDLESEAELTARFIRDAMPYQPSLLRT-----
Mvan_5003|M.vanbaalenii_PYR-1 TMTISTPADR------ETATADSDPELAARFEREALPLRDVLLRG-----
MLBr_01076|M.leprae_Br4923 TIMSHPPPSRDDDWVEPFDALQGTAVFDATGDKATMPSWEELVRQHAARV
: * . * *
Mb3250c|M.bovis_AF2122/97 ---ALRMTRNPADAEDLLQETMVKAYAGFRSFRHGTNLKAWLYRILTNTY
Rv3223c|M.tuberculosis_H37Rv ---ALRMTRNPADAEDLLQETMVKAYAGFRSFRHGTNLKAWLYRILTNTY
MMAR_1334|M.marinum_M ---ALRMTRNPADAEDLLQETMVKAYAGFRSFREGTNLKAWLYRILTNTY
MUL_2545|M.ulcerans_Agy99 ---ALRMTRNPADAEDLLQETMVKAYAGFRSFREGTNLKAWLYRILTNTY
MAV_4171|M.avium_104 ---ALRMTRNPADAEDLLQETMVKAYAGFRSFRAGTNLKAWLYRILTNTY
Mflv_4689|M.gilvum_PYR-GCK ---ALRMTRNPADAEDLLQETMVKAYSGFRSFREGTNLKAWLYRILTNTY
MAB_3543c|M.abscessus_ATCC_199 ---ALRMTRNPADAEDLVQETMVKAYAGFGTFKEGTNLKAWLYRILTNTY
TH_4436|M.thermoresistible__bu ---ARRLARTDADAEDLLQDTLMRAFVGFGSFEEGTNLKAWLFCIQHNQW
MSMEG_1690|M.smegmatis_MC2_155 ---ARRLARTEADAEDLVQDALLNAYVGFRRFRPGTNLRAWLFRIMHNRW
Mvan_5003|M.vanbaalenii_PYR-1 ---ARRLTTNEADAEDLLQDTLLAAYKGFRTFTPGTNIQAWLFRIMQNRW
MLBr_01076|M.leprae_Br4923 YWLAYRLSGNQHDAEDLTQETFIRVFRSVQNYQPGT-FEGWLHRITTNLF
* *:: . ***** *:::: .: .. : ** :..**. * * :
Mb3250c|M.bovis_AF2122/97 INSYRKKQRQPAEYPTEQITDWQLASNAEHSSTGLRSAEVEALEALPDTE
Rv3223c|M.tuberculosis_H37Rv INSYRKKQRQPAEYPTEQITDWQLASNAEHSSTGLRSAEVEALEALPDTE
MMAR_1334|M.marinum_M INSYRKKQRQPAEYPTDEITDWQLASNAEHSSTGLRSAEVEALEALPDTE
MUL_2545|M.ulcerans_Agy99 INSYRKKQRQPAEYPTDEITDWQLASNAEHSSTGLRSAEVEALEALPDTE
MAV_4171|M.avium_104 INSYRKKQRQPAEYPTEEITDWQLASNAEHSSTGLRSAEVEALESLPDSE
Mflv_4689|M.gilvum_PYR-GCK INSYRKKQRQPAEYPTEEITDWQLAANAEHTSTGLRSAEVEALELLPDSE
MAB_3543c|M.abscessus_ATCC_199 INIYRKKQRQPAEYPTEEITDWQLAANAEHTSTGLRSAEIEALDGLPDDE
TH_4436|M.thermoresistible__bu INDHRRRQRRPAEVSLDVLTDREVANHDTHARTAAPSAEREVLESLPDSG
MSMEG_1690|M.smegmatis_MC2_155 ISTHRMTQRRPATFCVDEVTDGDLAAGALHVSLGWRSAEDEALDTIPDAH
Mvan_5003|M.vanbaalenii_PYR-1 INNFRRKQRRVDEVTMDGITEGALAAGTRRAPAAPHSVEAELFGGIADDD
MLBr_01076|M.leprae_Br4923 LDMVRRRAR---------IRMDALPDDYDRVPADEPNPEQIYHDSRLGPD
:. * * : :. : . * .
Mb3250c|M.bovis_AF2122/97 IKEALQALPEEFRMAVYYADVEGFPYKEIAEIMDTPIGTVMSRLHRGRRQ
Rv3223c|M.tuberculosis_H37Rv IKEALQALPEEFRMAVYYADVEGFPYKEIAEIMDTPIGTVMSRLHRGRRQ
MMAR_1334|M.marinum_M IKEALQALPEEFRMAVYYADVEGFPYKEIAEIMDTPIGTVMSRLHRGRRQ
MUL_2545|M.ulcerans_Agy99 IKEALQALPEEFRMAVYYADVEGFPYKEIAEIMDTPIGTVMSRLHRGRRQ
MAV_4171|M.avium_104 IKDALQALPEEFRMAVYYADVEGFPYKEIAEIMDTPIGTVMSRLHRGRRQ
Mflv_4689|M.gilvum_PYR-GCK IKEALQALPEDFRMAVYYADVEGFPYKEIAEIMETPIGTVMSRLHRGRRQ
MAB_3543c|M.abscessus_ATCC_199 IKEALNKLPEEFRMAVYYADVEGFPYKEIAEIMDTPIGTVMSRLHRGRRQ
TH_4436|M.thermoresistible__bu IRAAMEQLSEGSRTVLYYADVEGCTYSETAARMNIPIGTVMSRASRARSQ
MSMEG_1690|M.smegmatis_MC2_155 VRTALDALPEGFRTVVYYADIEGFTYAETAVLMGIPVGTVMSRIARARQR
Mvan_5003|M.vanbaalenii_PYR-1 VTAALGALPEGYRLVLYYAEVEGYTYAETAAILSIPPGTVMSRVYRARQR
MLBr_01076|M.leprae_Br4923 LQAALDSLPPEFRAAVVLCDIEGLSYEEIGATLGVKLGTVRSRIHRGRQA
: *: *. * .: .::** .* * . : *** ** *.*
Mb3250c|M.bovis_AF2122/97 LRGLLAD-VARDRGFARGE--QAHEGVSS
Rv3223c|M.tuberculosis_H37Rv LRGLLAD-VARDRGFARGE--QAHEGVSS
MMAR_1334|M.marinum_M LRTLLAD-VAKERGFVRGE--QAHQEVSS
MUL_2545|M.ulcerans_Agy99 LRTLLAD-VAKERGFVRGE--QAHQEVSS
MAV_4171|M.avium_104 LRGLLAD-VAKERGFNRGQ--QTHEEVSS
Mflv_4689|M.gilvum_PYR-GCK LRELLAG-VARDRGFIRGEQLEAPEEVTS
MAB_3543c|M.abscessus_ATCC_199 LRDLLSE-VAKDRGFLRNN--ELAEGRA-
TH_4436|M.thermoresistible__bu LRRALQG-MAATTPAA-------------
MSMEG_1690|M.smegmatis_MC2_155 LRAALTEDAALNQDTEVTDNTQASADCAA
Mvan_5003|M.vanbaalenii_PYR-1 LRIALAH-KAVGRGAELDD------EIAA
MLBr_01076|M.leprae_Br4923 LRDYLLT--AHPRDGATTDATHVKSA---
** * *