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MRRSSIQWNQQPDNLFGGPVMDSPPEDTVLQRFERDVLPLLDQLYRAARRYTGSVADAEDLVQETMVKAY GGFHRFEDGTNVRAWLLRIMTNTWIKSYRRAQCRPEEVLSEDITDAQLAGHGRHSSTGLPSAELAALEAL GDDEVRDALGRLREDQRLVVYYADVEGLRYKEIALILDIPVGTVMSRLHRGRRALRSLLVDVATARGYLR DAAAA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_2297 | - | - | 100% (215) | ECF subfamily RNA polymerase sigma-24 factor |
| M. vanbaalenii PYR-1 | Mvan_1778 | - | 6e-60 | 63.13% (179) | ECF subfamily RNA polymerase sigma-24 factor |
| M. vanbaalenii PYR-1 | Mvan_5744 | - | 4e-47 | 49.21% (189) | ECF subfamily RNA polymerase sigma-24 factor |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3250c | sigH | 4e-61 | 61.86% (194) | RNA polymerase sigma factor RpoE |
| M. gilvum PYR-GCK | Mflv_4689 | - | 7e-60 | 63.13% (179) | ECF subfamily RNA polymerase sigma-24 factor |
| M. tuberculosis H37Rv | Rv3223c | sigH | 4e-61 | 61.86% (194) | RNA polymerase sigma factor RpoE |
| M. leprae Br4923 | MLBr_01076 | sigE | 4e-20 | 30.73% (205) | RNA polymerase sigma factor SigE |
| M. abscessus ATCC 19977 | MAB_3543c | - | 9e-62 | 64.44% (180) | RNA polymerase sigma-E factor |
| M. marinum M | MMAR_1334 | sigH | 1e-62 | 62.37% (194) | alternative RNA polymerase sigma-E factor (sigma- 24) SigH |
| M. avium 104 | MAV_4171 | - | 8e-61 | 64.80% (179) | RNA polymerase sigma factor RpoE |
| M. smegmatis MC2 155 | MSMEG_0574 | - | 1e-63 | 64.32% (185) | putative ECF sigma factor RpoE1 |
| M. thermoresistible (build 8) | TH_0665 | sigH | 3e-60 | 59.69% (196) | ALTERNATIVE RNA POLYMERASE SIGMA-E FACTOR (SIGMA-24) SIGH |
| M. ulcerans Agy99 | MUL_2545 | sigH | 6e-62 | 61.86% (194) | RNA polymerase sigma factor RpoE |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_4689|M.gilvum_PYR-GCK ---------------------MVPVMAMKAPSRSVFVLDVIGGAATEGTV
TH_0665|M.thermoresistible__bu --------------------------------------------------
Mb3250c|M.bovis_AF2122/97 --------------------------------------------------
Rv3223c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_1334|M.marinum_M --------------MSTSTSLLGEERLGRFPASPASVATLSGGTSTEGTV
MUL_2545|M.ulcerans_Agy99 --------------------------------------------------
MAV_4171|M.avium_104 -------------MVSTATSLLGEEQLAGFLASPGALSVLSGDTAAEGTG
MAB_3543c|M.abscessus_ATCC_199 ---------------------------MACLERPMSVPIRMVGVATERT-
Mvan_2297|M.vanbaalenii_PYR-1 ---------------------------------------------MRRSS
MSMEG_0574|M.smegmatis_MC2_155 --------------------------------------------------
MLBr_01076|M.leprae_Br4923 MGDGIGMEREGRWTGNTQCPLRVVPGDESPTLDGRASPEDLIITNLLSPT
Mflv_4689|M.gilvum_PYR-GCK FPTMTD----TNGLAASPAPADAG------EAREETDAELTARFERDAIP
TH_0665|M.thermoresistible__bu ---MTD----IEGTTPIRS--------------EESDAELTARFERDAIP
Mb3250c|M.bovis_AF2122/97 ---MAD----IDGVTGSAGLQP--------GPSEETDEELTARFERDAIP
Rv3223c|M.tuberculosis_H37Rv ---MAD----IDGVTGSAGLQP--------GPSEETDEELTARFERDAIP
MMAR_1334|M.marinum_M FIKMAD----IDGVTLAEAPDP--------EPPEETDEQLTARFERDAIP
MUL_2545|M.ulcerans_Agy99 ---MAD----IDGVTLAEAPDP--------EPPEETDEQLTACFERDAIP
MAV_4171|M.avium_104 FIEMADSPDGPDGVTSPEVPEAHAEPAAHEETREETDAELTARFERDAIP
MAB_3543c|M.abscessus_ATCC_199 --AVTS----MDSAAELPGLVH-----------VETEAERVARFERDALP
Mvan_2297|M.vanbaalenii_PYR-1 IQWNQQ----PDNLFGGPVMDS------------PPEDTVLQRFERDVLP
MSMEG_0574|M.smegmatis_MC2_155 MKEFTPHRQWQERVMAVTAEAQ-----------VTDHGSSAERFERDALP
MLBr_01076|M.leprae_Br4923 IMSHPPPSRDDDWVEPFDALQG------TAVFDATGDKATMPSWEELVRQ
: . :*. .
Mflv_4689|M.gilvum_PYR-GCK LLDQLYGGALRMTRNPADAEDLLQETMVKAYSGFRSFREGTNLKAWLYRI
TH_0665|M.thermoresistible__bu LLDQLYGGALRMTRNPADAEDLLQETMVKAYQGFRSFREGTNLKAWLYRI
Mb3250c|M.bovis_AF2122/97 LLDQLYGGALRMTRNPADAEDLLQETMVKAYAGFRSFRHGTNLKAWLYRI
Rv3223c|M.tuberculosis_H37Rv LLDQLYGGALRMTRNPADAEDLLQETMVKAYAGFRSFRHGTNLKAWLYRI
MMAR_1334|M.marinum_M LLDQLYGGALRMTRNPADAEDLLQETMVKAYAGFRSFREGTNLKAWLYRI
MUL_2545|M.ulcerans_Agy99 LLDQLYGGALRMTRNPADAEDLLQETMVKAYAGFRSFREGTNLKAWLYRI
MAV_4171|M.avium_104 LLDQLYGGALRMTRNPADAEDLLQETMVKAYAGFRSFRAGTNLKAWLYRI
MAB_3543c|M.abscessus_ATCC_199 LLDQLYGAALRMTRNPADAEDLVQETMVKAYAGFGTFKEGTNLKAWLYRI
Mvan_2297|M.vanbaalenii_PYR-1 LLDQLYRAARRYTGSVADAEDLVQETMVKAYGGFHRFEDGTNVRAWLLRI
MSMEG_0574|M.smegmatis_MC2_155 LLDQLYGVARRYTRNQADAEDLVQETMVKAYGSFHTYRDGTNIRAWLFKI
MLBr_01076|M.leprae_Br4923 HAARVYWLAYRLSGNQHDAEDLTQETFIRVFRSVQNYQPGT-FEGWLHRI
::* * * : . ***** ***:::.: .. :. ** ...** :*
Mflv_4689|M.gilvum_PYR-GCK LTNTYINSYRKKQRQPAEYPTEEITDWQLAANAEHTSTGLRSAEVEALEL
TH_0665|M.thermoresistible__bu LTNTYINNYRKRQRQPAVYPTEEFTDWQLASTAEHSSTGLRSAEVEALEA
Mb3250c|M.bovis_AF2122/97 LTNTYINSYRKKQRQPAEYPTEQITDWQLASNAEHSSTGLRSAEVEALEA
Rv3223c|M.tuberculosis_H37Rv LTNTYINSYRKKQRQPAEYPTEQITDWQLASNAEHSSTGLRSAEVEALEA
MMAR_1334|M.marinum_M LTNTYINSYRKKQRQPAEYPTDEITDWQLASNAEHSSTGLRSAEVEALEA
MUL_2545|M.ulcerans_Agy99 LTNTYINSYRKKQRQPAEYPTDEITDWQLASNAEHSSTGLRSAEVEALEA
MAV_4171|M.avium_104 LTNTYINSYRKKQRQPAEYPTEEITDWQLASNAEHSSTGLRSAEVEALES
MAB_3543c|M.abscessus_ATCC_199 LTNTYINIYRKKQRQPAEYPTEEITDWQLAANAEHTSTGLRSAEIEALDG
Mvan_2297|M.vanbaalenii_PYR-1 MTNTWIKSYRRAQCRPEEVLSEDITDAQLAGHGRHSSTGLPSAELAALEA
MSMEG_0574|M.smegmatis_MC2_155 LTNTWINAYHTAQRRPDVVVTDTISDAQLAAVATRSETELASAELAALES
MLBr_01076|M.leprae_Br4923 TTNLFLDMVRRRAR---------IRMDALPDDYDRVPADEPNPEQIYHDS
** ::. : : *. : : ..* :
Mflv_4689|M.gilvum_PYR-GCK LPDSEIKEALQALPEDFRMAVYYADVEGFPYKEIAEIMETPIGTVMSRLH
TH_0665|M.thermoresistible__bu LPDTEIKAALQELPEDFRIAVYLADVEGFPYKEIAEIMDTPIGTVMSRLH
Mb3250c|M.bovis_AF2122/97 LPDTEIKEALQALPEEFRMAVYYADVEGFPYKEIAEIMDTPIGTVMSRLH
Rv3223c|M.tuberculosis_H37Rv LPDTEIKEALQALPEEFRMAVYYADVEGFPYKEIAEIMDTPIGTVMSRLH
MMAR_1334|M.marinum_M LPDTEIKEALQALPEEFRMAVYYADVEGFPYKEIAEIMDTPIGTVMSRLH
MUL_2545|M.ulcerans_Agy99 LPDTEIKEALQALPEEFRMAVYYADVEGFPYKEIAEIMDTPIGTVMSRLH
MAV_4171|M.avium_104 LPDSEIKDALQALPEEFRMAVYYADVEGFPYKEIAEIMDTPIGTVMSRLH
MAB_3543c|M.abscessus_ATCC_199 LPDDEIKEALNKLPEEFRMAVYYADVEGFPYKEIAEIMDTPIGTVMSRLH
Mvan_2297|M.vanbaalenii_PYR-1 LGDDEVRDALGRLREDQRLVVYYADVEGLRYKEIALILDIPVGTVMSRLH
MSMEG_0574|M.smegmatis_MC2_155 MGDSEVRDAVAALPEHQRMAVYYADVVGMRYQEIADVLGVPVGTVMSRLH
MLBr_01076|M.leprae_Br4923 RLGPDLQAALDSLPPEFRAAVVLCDIEGLSYEEIGATLGVKLGTVRSRIH
. ::: *: * . * .* .*: *: *:**. : :*** **:*
Mflv_4689|M.gilvum_PYR-GCK RGRRQLRELLAGVARDRGFIRGEQLEAPEEVTS
TH_0665|M.thermoresistible__bu RGRRQLRSLLADVARERGIIRDQQAGTPEEVSS
Mb3250c|M.bovis_AF2122/97 RGRRQLRGLLADVARDRGFARGEQ--AHEGVSS
Rv3223c|M.tuberculosis_H37Rv RGRRQLRGLLADVARDRGFARGEQ--AHEGVSS
MMAR_1334|M.marinum_M RGRRQLRTLLADVAKERGFVRGEQ--AHQEVSS
MUL_2545|M.ulcerans_Agy99 RGRRQLRTLLADVAKERGFVRGEQ--AHQEVSS
MAV_4171|M.avium_104 RGRRQLRGLLADVAKERGFNRGQQ--THEEVSS
MAB_3543c|M.abscessus_ATCC_199 RGRRQLRDLLSEVAKDRGFLRNNE--LAEGRA-
Mvan_2297|M.vanbaalenii_PYR-1 RGRRALRSLLVDVATARGYLRDAA--AA-----
MSMEG_0574|M.smegmatis_MC2_155 RGRRRLREHLIGFAYQSGYLARPAGSAA-----
MLBr_01076|M.leprae_Br4923 RGRQALRDYLLTAHPRDGATTDATHVKSA----
***: ** * *