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VPVMAMKAPSRSVFVLDVIGGAATEGTVFPTMTDTNGLAASPAPADAGEAREETDAELTARFERDAIPLL DQLYGGALRMTRNPADAEDLLQETMVKAYSGFRSFREGTNLKAWLYRILTNTYINSYRKKQRQPAEYPTE EITDWQLAANAEHTSTGLRSAEVEALELLPDSEIKEALQALPEDFRMAVYYADVEGFPYKEIAEIMETPI GTVMSRLHRGRRQLRELLAGVARDRGFIRGEQLEAPEEVTS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_4689 | - | - | 100% (252) | ECF subfamily RNA polymerase sigma-24 factor |
| M. gilvum PYR-GCK | Mflv_1078 | - | 2e-43 | 52.75% (182) | ECF subfamily RNA polymerase sigma-24 factor |
| M. gilvum PYR-GCK | Mflv_2200 | - | 7e-20 | 33.14% (169) | RNA polymerase sigma factor SigE |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3250c | sigH | 1e-101 | 83.93% (224) | RNA polymerase sigma factor RpoE |
| M. tuberculosis H37Rv | Rv3223c | sigH | 1e-101 | 83.93% (224) | RNA polymerase sigma factor RpoE |
| M. leprae Br4923 | MLBr_01076 | sigE | 5e-20 | 33.94% (165) | RNA polymerase sigma factor SigE |
| M. abscessus ATCC 19977 | MAB_3543c | - | 2e-94 | 77.58% (223) | RNA polymerase sigma-E factor |
| M. marinum M | MMAR_1334 | sigH | 1e-107 | 80.66% (243) | alternative RNA polymerase sigma-E factor (sigma- 24) SigH |
| M. avium 104 | MAV_4171 | - | 1e-103 | 80.58% (242) | RNA polymerase sigma factor RpoE |
| M. smegmatis MC2 155 | MSMEG_1914 | - | 1e-108 | 87.50% (224) | RNA polymerase sigma-70 factor, family protein |
| M. thermoresistible (build 8) | TH_0665 | sigH | 1e-97 | 87.00% (200) | ALTERNATIVE RNA POLYMERASE SIGMA-E FACTOR (SIGMA-24) SIGH |
| M. ulcerans Agy99 | MUL_2545 | sigH | 1e-101 | 84.09% (220) | RNA polymerase sigma factor RpoE |
| M. vanbaalenii PYR-1 | Mvan_1778 | - | 1e-127 | 91.53% (248) | ECF subfamily RNA polymerase sigma-24 factor |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3250c|M.bovis_AF2122/97 ----------------------------------------MAD----IDG
Rv3223c|M.tuberculosis_H37Rv ----------------------------------------MAD----IDG
MMAR_1334|M.marinum_M -MSTSTSLLGEERLGRFPASPASVATLSGGTSTEGTVFIKMAD----IDG
MUL_2545|M.ulcerans_Agy99 ----------------------------------------MAD----IDG
MAV_4171|M.avium_104 MVSTATSLLGEEQLAGFLASPGALSVLSGDTAAEGTGFIEMADSPDGPDG
Mflv_4689|M.gilvum_PYR-GCK --------MVPVMAMKAPSRSVFVLDVIGGAATEGTVFPTMTD----TNG
Mvan_1778|M.vanbaalenii_PYR-1 ------------MAMEAPSRSVHVLDVIGGAATEGTVFPTMTD----ITG
MSMEG_1914|M.smegmatis_MC2_155 ------------------------------------MFPTMTD----VDR
TH_0665|M.thermoresistible__bu ----------------------------------------MTD----IEG
MAB_3543c|M.abscessus_ATCC_199 --------------MACLERPMSVPIRMVGVATERTAVTSMDS-------
MLBr_01076|M.leprae_Br4923 -MGDGIGMEREGRWTGNTQCPLRVVPGDESPTLDGRASPEDLIITNLLSP
Mb3250c|M.bovis_AF2122/97 VTGSAGLQP--------GPSEETDEELTARFERDAIPLLDQLYGG-----
Rv3223c|M.tuberculosis_H37Rv VTGSAGLQP--------GPSEETDEELTARFERDAIPLLDQLYGG-----
MMAR_1334|M.marinum_M VTLAEAPDP--------EPPEETDEQLTARFERDAIPLLDQLYGG-----
MUL_2545|M.ulcerans_Agy99 VTLAEAPDP--------EPPEETDEQLTACFERDAIPLLDQLYGG-----
MAV_4171|M.avium_104 VTSPEVPEAHAEPAAHEETREETDAELTARFERDAIPLLDQLYGG-----
Mflv_4689|M.gilvum_PYR-GCK LAASPAPADAG------EAREETDAELTARFERDAIPLLDQLYGG-----
Mvan_1778|M.vanbaalenii_PYR-1 SAAEATLDGEA------PAREETDAELTARFERDAIPLLDQLYGG-----
MSMEG_1914|M.smegmatis_MC2_155 VEPETPPE-----------REETDAELTARFERDAIPLLDQLYGG-----
TH_0665|M.thermoresistible__bu TTP--------------IRSEESDAELTARFERDAIPLLDQLYGG-----
MAB_3543c|M.abscessus_ATCC_199 --AAELPG---------LVHVETEAERVARFERDALPLLDQLYGA-----
MLBr_01076|M.leprae_Br4923 TIMSHPPPSRDDDWVEPFDALQGTAVFDATGDKATMPSWEELVRQHAARV
: * :: ::* ::*
Mb3250c|M.bovis_AF2122/97 ---ALRMTRNPADAEDLLQETMVKAYAGFRSFRHGTNLKAWLYRILTNTY
Rv3223c|M.tuberculosis_H37Rv ---ALRMTRNPADAEDLLQETMVKAYAGFRSFRHGTNLKAWLYRILTNTY
MMAR_1334|M.marinum_M ---ALRMTRNPADAEDLLQETMVKAYAGFRSFREGTNLKAWLYRILTNTY
MUL_2545|M.ulcerans_Agy99 ---ALRMTRNPADAEDLLQETMVKAYAGFRSFREGTNLKAWLYRILTNTY
MAV_4171|M.avium_104 ---ALRMTRNPADAEDLLQETMVKAYAGFRSFRAGTNLKAWLYRILTNTY
Mflv_4689|M.gilvum_PYR-GCK ---ALRMTRNPADAEDLLQETMVKAYSGFRSFREGTNLKAWLYRILTNTY
Mvan_1778|M.vanbaalenii_PYR-1 ---ALRMTRNPADAEDLLQETMVKAYSGFRSFREGTNLKAWLYRILTNTY
MSMEG_1914|M.smegmatis_MC2_155 ---ALRMTRNPADAEDLLQETMVKAYAGFRSFREGTNLKAWLYRILTNTY
TH_0665|M.thermoresistible__bu ---ALRMTRNPADAEDLLQETMVKAYQGFRSFREGTNLKAWLYRILTNTY
MAB_3543c|M.abscessus_ATCC_199 ---ALRMTRNPADAEDLVQETMVKAYAGFGTFKEGTNLKAWLYRILTNTY
MLBr_01076|M.leprae_Br4923 YWLAYRLSGNQHDAEDLTQETFIRVFRSVQNYQPGT-FEGWLHRITTNLF
* *:: * ***** ***:::.: .. .:: ** ::.**:** ** :
Mb3250c|M.bovis_AF2122/97 INSYRKKQRQPAEYPTEQITDWQLASNAEHSSTGLRSAEVEALEALPDTE
Rv3223c|M.tuberculosis_H37Rv INSYRKKQRQPAEYPTEQITDWQLASNAEHSSTGLRSAEVEALEALPDTE
MMAR_1334|M.marinum_M INSYRKKQRQPAEYPTDEITDWQLASNAEHSSTGLRSAEVEALEALPDTE
MUL_2545|M.ulcerans_Agy99 INSYRKKQRQPAEYPTDEITDWQLASNAEHSSTGLRSAEVEALEALPDTE
MAV_4171|M.avium_104 INSYRKKQRQPAEYPTEEITDWQLASNAEHSSTGLRSAEVEALESLPDSE
Mflv_4689|M.gilvum_PYR-GCK INSYRKKQRQPAEYPTEEITDWQLAANAEHTSTGLRSAEVEALELLPDSE
Mvan_1778|M.vanbaalenii_PYR-1 INSYRKKQRQPAEYPTEEITDWQLAANAEHSSTGLRSAEVEALELLPDNE
MSMEG_1914|M.smegmatis_MC2_155 INSYRKKQRQPSEYPTDEITDWQLASNAEHSSTGLRSAEVEALEALPDTE
TH_0665|M.thermoresistible__bu INNYRKRQRQPAVYPTEEFTDWQLASTAEHSSTGLRSAEVEALEALPDTE
MAB_3543c|M.abscessus_ATCC_199 INIYRKKQRQPAEYPTEEITDWQLAANAEHTSTGLRSAEIEALDGLPDDE
MLBr_01076|M.leprae_Br4923 LDMVRRRAR---------IRMDALPDDYDRVPADEPNPEQIYHDSRLGPD
:: *:: * : *. :: .:. ..* : . :
Mb3250c|M.bovis_AF2122/97 IKEALQALPEEFRMAVYYADVEGFPYKEIAEIMDTPIGTVMSRLHRGRRQ
Rv3223c|M.tuberculosis_H37Rv IKEALQALPEEFRMAVYYADVEGFPYKEIAEIMDTPIGTVMSRLHRGRRQ
MMAR_1334|M.marinum_M IKEALQALPEEFRMAVYYADVEGFPYKEIAEIMDTPIGTVMSRLHRGRRQ
MUL_2545|M.ulcerans_Agy99 IKEALQALPEEFRMAVYYADVEGFPYKEIAEIMDTPIGTVMSRLHRGRRQ
MAV_4171|M.avium_104 IKDALQALPEEFRMAVYYADVEGFPYKEIAEIMDTPIGTVMSRLHRGRRQ
Mflv_4689|M.gilvum_PYR-GCK IKEALQALPEDFRMAVYYADVEGFPYKEIAEIMETPIGTVMSRLHRGRRQ
Mvan_1778|M.vanbaalenii_PYR-1 IKEALQALPDEFRMAVYYADVEGFPYKEIAEIMDTPIGTVMSRLHRGRRQ
MSMEG_1914|M.smegmatis_MC2_155 IKAALQALPEEFRMAVYYADVEGFPYKEIAEIMETPIGTVMSRLHRGRRQ
TH_0665|M.thermoresistible__bu IKAALQELPEDFRIAVYLADVEGFPYKEIAEIMDTPIGTVMSRLHRGRRQ
MAB_3543c|M.abscessus_ATCC_199 IKEALNKLPEEFRMAVYYADVEGFPYKEIAEIMDTPIGTVMSRLHRGRRQ
MLBr_01076|M.leprae_Br4923 LQAALDSLPPEFRAAVVLCDIEGLSYEEIGATLGVKLGTVRSRIHRGRQA
:: **: ** :** ** .*:**:.*:**. : . :*** **:****:
Mb3250c|M.bovis_AF2122/97 LRGLLADVARDRGFARGEQAH--EGVSS
Rv3223c|M.tuberculosis_H37Rv LRGLLADVARDRGFARGEQAH--EGVSS
MMAR_1334|M.marinum_M LRTLLADVAKERGFVRGEQAH--QEVSS
MUL_2545|M.ulcerans_Agy99 LRTLLADVAKERGFVRGEQAH--QEVSS
MAV_4171|M.avium_104 LRGLLADVAKERGFNRGQQTH--EEVSS
Mflv_4689|M.gilvum_PYR-GCK LRELLAGVARDRGFIRGEQLEAPEEVTS
Mvan_1778|M.vanbaalenii_PYR-1 LRELLAGVARDRGFIRGEQVDAPEEVTS
MSMEG_1914|M.smegmatis_MC2_155 LRDLLAGVARDRGFIRGPQLGEPEEVTS
TH_0665|M.thermoresistible__bu LRSLLADVARERGIIRDQQAGTPEEVSS
MAB_3543c|M.abscessus_ATCC_199 LRDLLSEVAKDRGFLRNNELA--EGRA-
MLBr_01076|M.leprae_Br4923 LRDYLLTAHPRDGATTDATHVKSA----
** * . * .