For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
YVRAMSGSDVQAAVTALRTAFDDMAACDVDLLTRPDLVAALDELETLGCRLPSVSHRLLARLQAEATPPQ MGAKSWKEVLAVRWRISTSEAHRRLTEAAVLAPRQAMTGESLPPALPATATAQAHGLINAEHVEVIRKAM AKLPGFVDTATRERIEVDLVRTAVGNGPKELKDSADRTLFLLDQDGPEPDERERARKRAVTKHKQREDGM VDVSATLTPEAWAVWEAIFAKFAAPGMCNPDDPEPCTSGTPSQAQIDHDQRSLAQRQHDALLAGGRIALM SGELGKLNGLPVSVIIRTTLQDLESRAGVGVTGGGTVMPIAEVIRMAGHANHYLAVFDRATGSALDLFRT KRVASAAQRIMLIARDGGCTKPGCTVGAYGCQGHHVEADFAKGGNTNVDELGLACGPDNRSVDNNGGWTT QMNERCEVEWIPPPPLDTGQARINNYHRPERLLRPPEEPDPHSDNDTAASAKPAEGNEIGDAQPGAPQPA DNPSEPGGPAPPDNQAA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_4912 | - | - | 100% (508) | hypothetical protein Mvan_4912 |
| M. vanbaalenii PYR-1 | Mvan_4827 | - | 0.0 | 94.49% (508) | hypothetical protein Mvan_4827 |
| M. vanbaalenii PYR-1 | Mvan_3231 | - | 0.0 | 92.17% (511) | hypothetical protein Mvan_3231 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1159c | - | 1e-114 | 49.45% (453) | hypothetical protein Mb1159c |
| M. gilvum PYR-GCK | Mflv_4397 | - | 0.0 | 77.14% (503) | hypothetical protein Mflv_4397 |
| M. tuberculosis H37Rv | Rv1128c | - | 1e-113 | 49.23% (453) | hypothetical protein Rv1128c |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0394c | - | 8e-98 | 45.77% (426) | hypothetical protein MAB_0394c |
| M. marinum M | MMAR_1523 | - | 1e-109 | 47.89% (451) | hypothetical protein MMAR_1523 |
| M. avium 104 | MAV_2999 | - | 1e-112 | 47.72% (461) | hypothetical protein MAV_2999 |
| M. smegmatis MC2 155 | MSMEG_6573 | - | 1e-110 | 44.92% (472) | hypothetical protein MSMEG_6573 |
| M. thermoresistible (build 8) | TH_3287 | - | 5e-61 | 35.25% (488) | PUTATIVE conserved hypothetical protein |
| M. ulcerans Agy99 | MUL_2371 | - | 1e-106 | 45.23% (451) | hypothetical protein MUL_2371 |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_4912|M.vanbaalenii_PYR-1 ----MYVRAMSGSDVQAAVTALRTAFDDMAACDVDLLTRPDLVAALDELE
Mflv_4397|M.gilvum_PYR-GCK ---------MSGGDLQTSIAALRAAFEEVAAADVDLLTRPDLVAALDELE
MSMEG_6573|M.smegmatis_MC2_155 ---------MDDG-VQDAVAALDAALNTLLTLPHSALTDAELLTICAGLQ
Mb1159c|M.bovis_AF2122/97 ---MCS----TREEITEAFASLATALSRVLGLTFDALTTPERLALLEHCE
Rv1128c|M.tuberculosis_H37Rv ---MCS----TREEITEAFASLATALSRVLGLTFDALTTPERLALLEHCE
MAV_2999|M.avium_104 MRGMSS----DREAVSAAFDAIDAALDDLLDCDYAALATREKLALLNRCE
MMAR_1523|M.marinum_M ---MSS---MSREEVVAAFDALDAVMARLQDLCFDGLTTPERLALLQRCE
MUL_2371|M.ulcerans_Agy99 ---MHSNGCSDRESVVATLDRLDRAVDALVEVSFEALTTPERLRVLERLE
MAB_0394c|M.abscessus_ATCC_199 ---------------MSPIDDLLTTATAVVESSFDELNNPELLSALRQLE
TH_3287|M.thermoresistible__bu MGQQFVTAGAARARVGELLAAVDAAYAEMRALCLDEVGTGFRLELAERLE
. : . : : : :
Mvan_4912|M.vanbaalenii_PYR-1 TLGCRLPSVSHRLLARLQAEATPPQMGAKSWKEVLAVRWRISTSEAHRRL
Mflv_4397|M.gilvum_PYR-GCK ELSCQLPAVGHRLLARLQVETSAREMGAKSWNQVLAVRWRISTGEAHRRL
MSMEG_6573|M.smegmatis_MC2_155 DARNRIPAVEHRAIAALSQQTTPAAIGAKSWPLVLATRLGISSKEARRRC
Mb1159c|M.bovis_AF2122/97 TARRQLPSVEHTLINQIGEQSTEEELGGK-LGLTLADRLRITRSEAKRRV
Rv1128c|M.tuberculosis_H37Rv TARRQLPSVEHTLINQIGEQSTEEELGGK-LGLTLADRLRITRSEAKRRV
MAV_2999|M.avium_104 RLRRRLPAIEHPLINALARDATPAELGGR-LSHAIAEATLISRAEAARRV
MMAR_1523|M.marinum_M VARRRLPSIEHPLINQLVEQAGEQELGGK-LAAVLAGRLRVSRGEASRRL
MUL_2371|M.ulcerans_Agy99 VVARRLPAAQYALVNQLDEQPGEAELGGR-LAAVVASRLRITRSEAGRRV
MAB_0394c|M.abscessus_ATCC_199 IAQRKITAASHTLTARLVQRGSPVALGGTSFAEVLARYLSITTATARRRL
TH_3287|M.thermoresistible__bu TQCRINRGLMYRVFAQLADPPDEPAMVPA-VRDRLWARLRITPGEVKRRL
. : : : : :: . **
Mvan_4912|M.vanbaalenii_PYR-1 TEAAVLAPRQAMTGESLPPALPATATAQAHGLINAEHVEVIRKAMAKLPG
Mflv_4397|M.gilvum_PYR-GCK TEAALLAPRQSLTGTPLPPALPATAVAQSRGLINAEHVEVIRKAVKKLPG
MSMEG_6573|M.smegmatis_MC2_155 TDAAELGPRVSMTGEALAPKREHIAAAQADGTLTPDHVAELFKFFTKCPD
Mb1159c|M.bovis_AF2122/97 AEAADLGQRRALTGEPLPPLLTATAKAQRHGLIGDGHVEVIRAFVHRLPS
Rv1128c|M.tuberculosis_H37Rv AEAADLGQRRALTGEPLPPLLTATAKAQRHGLIGDGHVEVIRAFVHRLPS
MAV_2999|M.avium_104 HTAADLGPRVGLTGEPLPPLLAATAAAQREGSLGLEQVAVIRKFCHQLPG
MMAR_1523|M.marinum_M REAADLGPRRALTGEQLAPLLSATASAVRQGRIGAGHVRVIREFCGQVPA
MUL_2371|M.ulcerans_Agy99 AEAAEVGPRRALSGQPVGPVLTATAAALRQGVVGEGHVRVIRDFFRQLPA
MAB_0394c|M.abscessus_ATCC_199 ADAAHLGPRRALTGEPLRPALPYVAHALREGRLGDEHVRIIRRFFDVLPD
TH_3287|M.thermoresistible__bu RVAALLRPRRRLSGPPLPPVLARVAGAVESGLLGEEHLRVITTVMAALPS
** : * ::* : * * * * : :: : *
Mvan_4912|M.vanbaalenii_PYR-1 FVDTATRERIEVDLVRTAVGNGPKELKDSADRTLFLLDQDGPEPDERERA
Mflv_4397|M.gilvum_PYR-GCK WVDVATREQFEVNLVRTAVGNGPKELRDAAELTLFLLDQDGPEPDDTERA
MSMEG_6573|M.smegmatis_MC2_155 WVTYAEQCRLEEKLVTGAIGADPETVRQAVDHAVFLLDQDGPAPTDNPPT
Mb1159c|M.bovis_AF2122/97 WVDLKTLEKAERDLAKQATQYRPDQLAKLAARIMDCLNPDGDYTDE-DRA
Rv1128c|M.tuberculosis_H37Rv WVDLKTLEKAERDLAKQATQYRPDQLAKLAARIMDCLNPDGDYTDE-DRA
MAV_2999|M.avium_104 WIDQATRERAEADLANQGTRYRPEQLAALAGTLADCLNPDGLYRDE-DRA
MMAR_1523|M.marinum_M EVDLETRERAEAHLARLAGQFRPDQLAKLAQRLMDCVNPDGRYSDE-DRA
MUL_2371|M.ulcerans_Agy99 GVDVGTRDRAEAHLAKLATQFRPDQLARLAGRLMDCLNPDGRHSDE-DRA
MAB_0394c|M.abscessus_ATCC_199 AVDADTREAAEKQLASMGTEFGPEQLRAGADRIAALVNPDGRFSDI-DRA
TH_3287|M.thermoresistible__bu AVSVTDREAVEASLIAEAARSDAGIVRQVGRRIEEIFNPDGHYDDQ-DRA
: * * . . : .: ** :
Mvan_4912|M.vanbaalenii_PYR-1 RKRAVTKHKQREDGMVDVSATLTPEAWAVWEAIFAKFAAP----------
Mflv_4397|M.gilvum_PYR-GCK RKRGLTKGKQRPDGMIDLAGTLTPEAWAVLEVIFAKYAAP----------
MSMEG_6573|M.smegmatis_MC2_155 KPFGITFGPQQPDGSYHLRGKVSAEFKATFDPIDEKLAAP----------
Mb1159c|M.bovis_AF2122/97 RRRGLTLGKQDVDGMSRLSGYVTPELRATIEAVWAKLAAP----------
Rv1128c|M.tuberculosis_H37Rv RRRGLTLGKQDVDGMSRLSGYVTPELRATIEAVWAKLAAP----------
MAV_2999|M.avium_104 RRRSLTLGNQHADGMSELRGLLTPELRATLEAVLAKLAAP----------
MMAR_1523|M.marinum_M RRRGLTLGRQGRDGMSRISGWLTPEARAGLDAVLAKLAAP----------
MUL_2371|M.ulcerans_Agy99 RRRGLSLGRQGLDGMSRISGWLTPEARAGLEAVWAKLAAP----------
MAB_0394c|M.abscessus_ATCC_199 RRRGISIGRQGADGMSALSGLLDPETRAYFDAVLSKLAAP----------
TH_3287|M.thermoresistible__bu RRRGIHLGDQQRDGMSAISGWIDPQLRAYLEAVTAAVRPGRHLPHTTTDT
: .: * ** : . : .: * : : .
Mvan_4912|M.vanbaalenii_PYR-1 ----------GMCNPDDPEPCTSGTPSQAQIDHDQ-----RSLAQRQHDA
Mflv_4397|M.gilvum_PYR-GCK ----------GMCNPADPEPCTYGTPTQAQIDNDQ-----RSLAQRQHDA
MSMEG_6573|M.smegmatis_MC2_155 ----------GMCNPTDQTPCISGTPSQQQIDSDQ-----RGAPERRHDA
Mb1159c|M.bovis_AF2122/97 ----------GMCNPEQKAPCVNGAPSKEQARRDT-----RSCPQRNHDA
Rv1128c|M.tuberculosis_H37Rv ----------GMCNPEQKAPCVNGAPSKEQARRDT-----RSCPQRNHDA
MAV_2999|M.avium_104 ----------GMCNPLDESPCVDGTPTEQAIEGDT-----RSAAQRNHDG
MMAR_1523|M.marinum_M ----------GMCNPDDESPVVQAPAGADAVSRDR-----RSVGQRHHDG
MUL_2371|M.ulcerans_Agy99 ----------GMCNPEDEAAVVDGPVSRDAADRDS-----RSVSQRQHDG
MAB_0394c|M.abscessus_ATCC_199 ----------GMCDPRDESPMTEGEPDSAAAERDT-----RTSAQRNHDG
TH_3287|M.thermoresistible__bu TGTTGTTETTGTAGTAGTAATAADTAADGVGDIDTGGVDLRSAAQRRHDG
* ... . * * :*.**.
Mvan_4912|M.vanbaalenii_PYR-1 LLAGGRIALMSGELGKLNGLPVSVIIRTTLQDLESRA-----------GV
Mflv_4397|M.gilvum_PYR-GCK LVAVGRIALMSGELGQLNGLPVSIIIRTTLQDLESRA-----------GV
MSMEG_6573|M.smegmatis_MC2_155 MLTAMRLLLAHKDLGQINGLPATLLVTTTLQELEKAA-----------GV
Mb1159c|M.bovis_AF2122/97 LNAGLRSLLTSGNLGQHNGLPASIIVTTTLKDLEAAA-----------GA
Rv1128c|M.tuberculosis_H37Rv LNAELRSLLTSGNLGQHNGLPASIIVTTTLKDLEAAA-----------GA
MAV_2999|M.avium_104 LLAGLRALLASGNLGQHNGLPASIIVTTTLADLETAA-----------GK
MMAR_1523|M.marinum_M LNAAVRALLASGDLGQHNGLPASIIVTTTLGELQRAC-----------GR
MUL_2371|M.ulcerans_Agy99 FNAALRAVLASGELGQHNGLPASIIVSTTLKELEAAA-----------GR
MAB_0394c|M.abscessus_ATCC_199 LRACLRSTLASGKLGAHRGLPVTVVVSTTLRELQSAA-----------GR
TH_3287|M.thermoresistible__bu LTLGLKIAVASGRLGSHRGHPVTVIVRTTLGELNQAAHAVADPRVSMPGP
: : : ** .* *.:::: *** :*: . *
Mvan_4912|M.vanbaalenii_PYR-1 GVTGGGTVMPIAEVIRMAGHANHYLAVFDRATGSALDLFRTKRVASAAQR
Mflv_4397|M.gilvum_PYR-GCK GTTGGGTVVPIKDVIRMAGHANHYLAVFDRATGSALDLFRTRRVASPAQR
MSMEG_6573|M.smegmatis_MC2_155 AITAGGTKLSIPDLIRLASQALHYLAVYDEHTGIPLYLGRARRTASAGQR
Mb1159c|M.bovis_AF2122/97 GLTGGGTILPISDVIRLARHANHYLAIFDR--GKALALYHTKRLASPAQR
Rv1128c|M.tuberculosis_H37Rv GLTGGGTILPISDVIRLARHANHYLAIFDR--GKALALYHTKRLASPAQR
MAV_2999|M.avium_104 GLTGGGTLLPMSDVIRLSRHAHHYLAIFDK--GKALALYHTKRLASPGQR
MMAR_1523|M.marinum_M GLTGGGTVLPISDVIRLARHAHHYLAVFDR--GKAVGLYHAKRLATAGQR
MUL_2371|M.ulcerans_Agy99 GLTGGGTLLPMSDVIRLARHAHHYLAVFDR--GEAIGLYHAKRLATPGQR
MAB_0394c|M.abscessus_ATCC_199 AISGSGNLVPIPDLIRMATHAFHYLTIFGD-DGRPLHLGRSKRIATPDQR
TH_3287|M.thermoresistible__bu ARTGGTGVLPMRELIRMAADAIHYLAVFDDHTERPLYLGRQKRIATADQR
. :.. :.: ::**:: .* ***:::. .: * : :* *:. **
Mvan_4912|M.vanbaalenii_PYR-1 IMLIARDGGCTKPGCTVGAYGCQGHHVEADFAKGGNTNVDELGLACGPDN
Mflv_4397|M.gilvum_PYR-GCK VMLIARDGGCTKPCCTVGAYGCQVHHAETDYAHGGNTNIDELGLACGPDN
MSMEG_6573|M.smegmatis_MC2_155 LAIWARDRGCTRPGCTANGYRCQAHHATTDYAKGGLTDADALALACGCDN
Mb1159c|M.bovis_AF2122/97 IMLYAKDSGCSAPGCDVPGYYCEVHHVT-PYAQCRNTDVNDLTLGCGGHH
Rv1128c|M.tuberculosis_H37Rv IMLYAKDSGCSAPGCDVPGYYCEVHHVT-PYAQCRNTDVNDLTLGCGGHH
MAV_2999|M.avium_104 IVLYAKDRGCTAPGCTVPGYYAEVHHCT-DYATCHTTDINDLTFACGPHH
MMAR_1523|M.marinum_M LVLYAKDRGCTRPGCDVPGYQCEVHHVA-AWATSGRTDIDQLTLACGPDH
MUL_2371|M.ulcerans_Agy99 IVLYAKDRGCTRPGCDVAGYQCEVHHVA-AWAISGRTDINQLTLACGPDH
MAB_0394c|M.abscessus_ATCC_199 IVLHAKDRGCSAPGCTVPGYLCQVHHVD-DWRDDGPTDIDNLTFACGPHH
TH_3287|M.thermoresistible__bu LICYARDGGCTAPGCGEPGYHAETHHQP-AWEDGGLTDADHLFFACGPHH
: *:* **: * * .* .: ** : *: : * :.** .:
Mvan_4912|M.vanbaalenii_PYR-1 RSVDN-NGGWTTQMN-ERCEVEWIPPPPLDTGQARINNYHRPERLLRPPE
Mflv_4397|M.gilvum_PYR-GCK RSVT--EGGWTTRIN-DRCEVEWIPPPGLDTGQARVNTYHRPERLLAPPD
MSMEG_6573|M.smegmatis_MC2_155 RLVGEAPNKWTTRIN-NHGQCEWIPPDLLDRGQHRTNTYHHPETLLADIN
Mb1159c|M.bovis_AF2122/97 PLAERG---WTTRKN-AHGDTEWLPPPHLDHGQPRVNTFHHPEKLL----
Rv1128c|M.tuberculosis_H37Rv PLAERG---WTTRKN-AHGDTEWLPPPHLDHGQPRVNTFHHPEKLL----
MAV_2999|M.avium_104 RLLQPGA--WTTHKN-ARGETQWLPPPHLDRNQPRTNTFHHPEKLLRGED
MMAR_1523|M.marinum_M KLLEQG---WRTRKN-AHGDTEWLPPPHLDHGQPRTNTYHHPEKLLR---
MUL_2371|M.ulcerans_Agy99 KLLEQG---WRTRKN-AHGDTEWLPPPHLDHGQPRTNSYHHPEKLLR---
MAB_0394c|M.abscessus_ATCC_199 RLLQQG---WTTRKRRSDGITEWIPPPHLDTGQSRTNDHHHPERFIRRF-
TH_3287|M.thermoresistible__bu SGLTEGR--WQATIT-PTGRLAWTN----DHHPPTVNHAHHPEELLR---
* : * * * *:** ::
Mvan_4912|M.vanbaalenii_PYR-1 -------EPDPHSDNDTAASAKPAEGNEIGDAQPGAPQPADNPSEPGGP-
Mflv_4397|M.gilvum_PYR-GCK -------DPEPPNQTRTTAT-EPVEDQAIDDPETDAPPPLDDPGEPGGP-
MSMEG_6573|M.smegmatis_MC2_155 RDQKTDGDNREQHHTDTGADTGTVHVNGHGEKPAIPPELLDQGQQRTAPY
Mb1159c|M.bovis_AF2122/97 -------------ADDEGDP------------------------------
Rv1128c|M.tuberculosis_H37Rv -------------ADDEGDP------------------------------
MAV_2999|M.avium_104 -----------GGEDDDGDDDEAA--------------------------
MMAR_1523|M.marinum_M -----------DSAADEGEEGG----------------------------
MUL_2371|M.ulcerans_Agy99 -----------DSADDDDEGHGAA--------------------------
MAB_0394c|M.abscessus_ATCC_199 --------------------------------------------------
TH_3287|M.thermoresistible__bu ------------AHTDPPEDPG----------------------------
Mvan_4912|M.vanbaalenii_PYR-1 ----APPDNQAA--------------------------------------
Mflv_4397|M.gilvum_PYR-GCK ----APPDNRAA--------------------------------------
MSMEG_6573|M.smegmatis_MC2_155 HQAEVPPVNTRDTRSSTTTRDANRHNGNGDRNSAENRNGPSKNAAGDDDE
Mb1159c|M.bovis_AF2122/97 --------------------------------------------------
Rv1128c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_2999|M.avium_104 --------------------------------------------------
MMAR_1523|M.marinum_M --------------------------------------------------
MUL_2371|M.ulcerans_Agy99 --------------------------------------------------
MAB_0394c|M.abscessus_ATCC_199 --------------------------------------------------
TH_3287|M.thermoresistible__bu --------------------------------------------------
Mvan_4912|M.vanbaalenii_PYR-1 --
Mflv_4397|M.gilvum_PYR-GCK --
MSMEG_6573|M.smegmatis_MC2_155 PR
Mb1159c|M.bovis_AF2122/97 --
Rv1128c|M.tuberculosis_H37Rv --
MAV_2999|M.avium_104 --
MMAR_1523|M.marinum_M --
MUL_2371|M.ulcerans_Agy99 --
MAB_0394c|M.abscessus_ATCC_199 --
TH_3287|M.thermoresistible__bu --