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MTKLISKPLELPAFVTPNRVFMAPMTRMRAAQPGDVPTDLMVDYYTQRAGAGLIVTEGSQISPEGKGYAD TPGIHSDAQVAGWRKVTDAVHAAGGRISLQLWHVGRLTHETLQGGQPGVSASAIDFDGTVTLKHADGERY TAQSPTPRALEVSEIPRLIEDYRRATRNAREAGFDMVEIHAANGYLLQQFMSVSSNHRDDRYGGSLQNRA RLPLEVVDALTDEWDAAHVGIRLSPMIKFGGLDDADGMEMGLYMAAALHERGVGYLHLCEPDWAEGPALD SAFRSGLRNAFSGIIIGAGNYTVAKADEMIAEGFIDAAAFGRPFIANPDLPRRLFEELPLAEVDFDTVYG SDVAGYPQGYTDYPTAD
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_4790 | - | - | 100% (367) | NADH:flavin oxidoreductase/NADH oxidase |
| M. vanbaalenii PYR-1 | Mvan_5069 | - | 8e-62 | 39.24% (367) | NADH:flavin oxidoreductase/NADH oxidase |
| M. vanbaalenii PYR-1 | Mvan_2881 | - | 2e-19 | 30.86% (243) | NADH:flavin oxidoreductase/NADH oxidase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1208c | fadH | 7e-22 | 31.60% (212) | NADPH dependent 2,4-dienoyl-CoA reductase |
| M. gilvum PYR-GCK | Mflv_1689 | - | 1e-61 | 40.22% (368) | NADH:flavin oxidoreductase/NADH oxidase |
| M. tuberculosis H37Rv | Rv1175c | fadH | 2e-22 | 32.08% (212) | NADPH dependent 2,4-dienoyl-CoA reductase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0830 | - | 7e-59 | 37.36% (364) | NADH-dependent flavin oxidoreductase |
| M. marinum M | MMAR_4276 | fadH | 7e-22 | 33.02% (212) | NADPH dependent 2,4-dienoyl-CoA reductase FadH |
| M. avium 104 | MAV_4324 | - | 9e-19 | 27.60% (250) | oxidoreductase, FAD/FMN-binding superfamily protein |
| M. smegmatis MC2 155 | MSMEG_2969 | - | 1e-48 | 37.61% (343) | NADH:flavin oxidoreductase/NADH oxidase |
| M. thermoresistible (build 8) | TH_3970 | - | 3e-23 | 27.66% (329) | PUTATIVE putative NADH:flavin oxidoreductase/nadh oxidase |
| M. ulcerans Agy99 | MUL_1023 | fadH | 3e-22 | 33.49% (212) | NADPH dependent 2,4-dienoyl-CoA reductase FadH |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1689|M.gilvum_PYR-GCK ----MTFTLSEQSALLKPIQVG-GTAAGNRLFMAPLTRSRADADG-TPSS
MAB_0830|M.abscessus_ATCC_1997 ----MAFTLDPQAALLKPIRMG-EVVASNRILMAPMTRSRAQGDG-TPSE
Mvan_4790|M.vanbaalenii_PYR-1 ----MTKLIS------KPLELP-AFVTPNRVFMAPMTRMRAAQPGDVPTD
MSMEG_2969|M.smegmatis_MC2_155 ----MTNTHP----ALTSVRLG-GLKLDNRFAVAPMTRVSATADG-APTD
Mb1208c|M.bovis_AF2122/97 ----MTNPYPN---LLSPLDLG-FTTLRNRVVMGSMHTGLEDRAR--HID
Rv1175c|M.tuberculosis_H37Rv ----MTNPYPN---LLSPLDLG-FTTLRNRVVMGSMHTGLEDRAR--HID
MMAR_4276|M.marinum_M ----MTSPYPN---LLSPLDLG-FTTLRNRVVMGSMHTGLEDRPK--DTD
MUL_1023|M.ulcerans_Agy99 ----MTSPYPN---LLFPLDLG-FTTLRNRVVMGSMHTGLEDRPK--DTD
TH_3970|M.thermoresistible__bu MCGRRRDEMVPMTDLSAPLRFAHGPTWRNRLALAPLTNMQSNADG-TLHD
MAV_4324|M.avium_104 --------MPTPPDVFSPAKLG-PITLRNRIIKSATFEARTPDAL--VTD
. . **. .. .
Mflv_1689|M.gilvum_PYR-GCK LAAQYYAQRAS--AGLIISEATAVCEQANGAYLNTPGLYTDRQQDKWSEI
MAB_0830|M.abscessus_ATCC_1997 FAPVYYGQRAS--AGLIISEATAISQAGNGAYMNTPGIYTDRHQHKWAEI
Mvan_4790|M.vanbaalenii_PYR-1 LMVDYYTQRAG--AGLIVTEGSQISPEGKG-YADTPGIHSDAQVAGWRKV
MSMEG_2969|M.smegmatis_MC2_155 AMAGYYAEFARGGFGLVITEGTYTDTTHSQGYLNQPGLATDAHAAGWRPV
Mb1208c|M.bovis_AF2122/97 RLADYFAERARGGVGLIITGG-YAPNRTGWLLPFASELVTSAQARRHRRI
Rv1175c|M.tuberculosis_H37Rv RLADYFAERARGGVGLIITGG-YAPNRTGWLLPFASELVTSAQARRHRRI
MMAR_4276|M.marinum_M RLAEYFAERARGGVGMLITGG-YAPNRTGWLYPFASELVTPAEARRHRRI
MUL_1023|M.ulcerans_Agy99 RLAEYFAERARGGVGMLITGG-YAPNRTGWLYPFASELVTPAEARRHRRI
TH_3970|M.thermoresistible__bu DEHHWLVRRAEGGFAMVMTCAAHVSQ-AGQAFPGQLGVWHDRHLPGLTRL
MAV_4324|M.avium_104 DLIEYHRLPAAG--GVGMTTVAYCAVSPGGRTEGNGIWMRPEAVPGFRRL
: * .: :: :
Mflv_1689|M.gilvum_PYR-GCK ASAVHRAGGKMFVQLWHVGRMAHPEISG-FETVGPSPIAAD--LLTHTPT
MAB_0830|M.abscessus_ATCC_1997 AETVHSEGSKMFLQIWHVGRLGHPAVSGGFEPVAPSAVAAQ--MTTHTPS
Mvan_4790|M.vanbaalenii_PYR-1 TDAVHAAGGRISLQLWHVGRLTHETLQGGQPGVSASAIDFDGTVTLKHAD
MSMEG_2969|M.smegmatis_MC2_155 TDAVHAAGVPIVAQLMHAGALSQGNSHG-VETIAPSAVAPRGTMLEEYGG
Mb1208c|M.bovis_AF2122/97 NRAVHDSGAKILLQILHAGRYAYHPLAVSASPIKAPITPFR---------
Rv1175c|M.tuberculosis_H37Rv TRAVHDSGAKILLQILHAGRYAYHPLAVSASPIKAPITPFR---------
MMAR_4276|M.marinum_M TGAVHDADAKILLQVLHAGRYAYHPLSVSASSIKAPINPFR---------
MUL_1023|M.ulcerans_Agy99 TGAVHDADAKILLQVLHAGRYAYHPLSVSASSIKAPINPFR---------
TH_3970|M.thermoresistible__bu AAGIRAAGAVATVQLHHGGRRAEARLTG-LPVVAPWDDPDKG--------
MAV_4324|M.avium_104 TDAIHAEGAAVSAQIGHAGPVANARSNKAHALAPVRFFNPIG--------
:: . *: * *
Mflv_1689|M.gilvum_PYR-GCK GK---KPLPVPRALTTGEIAEIVGQFRAAARRAVDAGMDGVEIHSANGYL
MAB_0830|M.abscessus_ATCC_1997 GK---VPLVIPRELRIDEIAEIVDDFRAAARRAIDAGLDGVEIHGANGYL
Mvan_4790|M.vanbaalenii_PYR-1 GERYTAQSPTPRALEVSEIPRLIEDYRRATRNAREAGFDMVEIHAANGYL
MSMEG_2969|M.smegmatis_MC2_155 AG----TWPTPREMSAADIDAAIAGFVDAAVRARAAGFDGVEIHAANGYL
Mb1208c|M.bovis_AF2122/97 ----------PRALSARGVEATIADFARCAQLARDAGYDGVEIMGSEGYL
Rv1175c|M.tuberculosis_H37Rv ----------PRALSARGVEATIADFARCAQLARDAGYDGVEIMGSEGYL
MMAR_4276|M.marinum_M ----------PRKLTSRGVEATIADFARCAQLAQEAGYDGVEIMGSEGYL
MUL_1023|M.ulcerans_Agy99 ----------SRKLTSRGVEATIADFARCAQLAQEAGYDGVEIMGSEGYL
TH_3970|M.thermoresistible__bu ----------VTALTTAQVEQVVQDFVDAAVRAEKAGFDGAEIHGAHGYL
MAV_4324|M.avium_104 -------MRFAKKATREDIDEVIAAHANAARLAIEAGFDAVEIHLGHNYL
: : . .: * ** * .** ...**
Mflv_1689|M.gilvum_PYR-GCK LHEFLSDVVNQRTDAYGGSPQNRARLAAEVVEAVV---AEIGPD-RVGLR
MAB_0830|M.abscessus_ATCC_1997 LHQFSSDVINQRTDIYGGSPENRARLTAEVVEAVA---AEVGPT-RVGVR
Mvan_4790|M.vanbaalenii_PYR-1 LQQFMSVSSNHRDDRYGGSLQNRARLPLEVVDALT---DEWDAA-HVGIR
MSMEG_2969|M.smegmatis_MC2_155 LDQFLTTYTNHRTDEYGGTVAHRIRLAAQISAAVR---TAVGADFLVGVR
Mb1208c|M.bovis_AF2122/97 LNQFLAPRTNKRTDSWGGTPANRRRFPVEIIRRSR---AAVGSDFIICYR
Rv1175c|M.tuberculosis_H37Rv LNQFLAPRTNKRTDSWGGTPANRRRFPVEIIRRSR---AAVGCDFIICYR
MMAR_4276|M.marinum_M LNQFLAPRTNKRTDSWGGTPAKRRRFPVEIVRRTR---AAVGPDFIICYR
MUL_1023|M.ulcerans_Agy99 LNQFLAPRTNQRTDSWGGTPAKRRRFPVEIVRRTR---AAVGPDFIICYR
TH_3970|M.thermoresistible__bu VAQFLDVRHNHRTDRYGGSPENRFRIVHEIIAGIR---AATSPDFQLGLR
MAV_4324|M.avium_104 ASSFLSPLINRRNDEFGGSLQNRAKVARGMVMAVRRAVEKEGTPIAVTAK
.* *:* * :**: :* :. : . : :
Mflv_1689|M.gilvum_PYR-GCK ISPGNS-AGDMREIDDVSAYEALLCR---IASLGIAYLHVLVEPS-----
MAB_0830|M.abscessus_ATCC_1997 ISPGTS-AGDMHENDTVSTYAALLER---IDPLGLAYLHVVIDPG-----
Mvan_4790|M.vanbaalenii_PYR-1 LSPMIK-FGGLDDADGMEMGLYMAAA---LHERGVGYLH-LCEPD-----
MSMEG_2969|M.smegmatis_MC2_155 LSQTKVNDFEYRWPGGAQDAEVIFTA---LAATGIDYLHIASEGRDFID-
Mb1208c|M.bovis_AF2122/97 LSMADYVAEGQSWDEIVALATEVEGAGATIINSGFGWHEARVPTIVT---
Rv1175c|M.tuberculosis_H37Rv LSMADYVAEGQSWDEIVALATEVEGAGATIINSGFGWHEARVPTIVT---
MMAR_4276|M.marinum_M MSMADYVEGGQSWDEIVALASELETAGATIINSGFGWHEARIPTIVT---
MUL_1023|M.ulcerans_Agy99 MSMADYVEGGQSWDEIVALATELESAGATIINSGFGWHEARIPTIVT---
TH_3970|M.thermoresistible__bu LSPERY---GIVLDEARALAGEVLADG-QLDYLDLSLWDAFKEPYEE---
MAV_4324|M.avium_104 LNMADGVRGGISTEESLTTAKWLESDG-GLDAIELTAGSSLVNPMYLFRG
:. : : .
Mflv_1689|M.gilvum_PYR-GCK APAFAAVRTQWEGTLVLNTP----RTVETDFATLENLADWGVISAAAVGR
MAB_0830|M.abscessus_ATCC_1997 AVELRAMGAMWSNNLVLNSS----TETETEFCVLEGLVESGAVNAVALGR
Mvan_4790|M.vanbaalenii_PYR-1 WAEGPALDSAFRSGLRNAFSGIIIGAGNYTVAKADEMIAEGFIDAAAFGR
MSMEG_2969|M.smegmatis_MC2_155 GARLDDGRTITALARQVTGLPVIANGGMHDTTQAAGVLDGGHADVLSIGR
Mb1208c|M.bovis_AF2122/97 SVPGGAFVDISSAVAEHVTIPVVASNRINMPQAAERILAETQVRLISMAR
Rv1175c|M.tuberculosis_H37Rv SVPGGAFVDISSAVAEHVTIPVVASNRINMPQAAERILAETQVRLISMAR
MMAR_4276|M.marinum_M SVPSGAFVDISNAVAEQVSIPVMTSNRINMPQAAEQILADTDVALISMAR
MUL_1023|M.ulcerans_Agy99 SVPSGAFVEISNAVAEQVSIPVMTSNRINMPQAAEQILADTDVALISMAR
TH_3970|M.thermoresistible__bu -AHRGRRLIELFMDLPRGDTRVGVAGKITDAESARRCLDSG-ADFVLIGK
MAV_4324|M.avium_104 DAPLKEFAGAFKPPLRWGMRMTGKKFLREYPYREAYLLRDAKLFRAELKM
.
Mflv_1689|M.gilvum_PYR-GCK AFLANPDLIERLKLG-----------------------------------
MAB_0830|M.abscessus_ATCC_1997 KFLANPDLIDRLLLG-----------------------------------
Mvan_4790|M.vanbaalenii_PYR-1 PFIANPDLPRRLFEE-----------------------------------
MSMEG_2969|M.smegmatis_MC2_155 GALANPDLPQRVSSG-----------------------------------
Mb1208c|M.bovis_AF2122/97 PMLSDPDWVLKAQSNRVDEINTCISCNQACLDHAFARKTVSCLLNPRAGR
Rv1175c|M.tuberculosis_H37Rv PMLSDPDWVLKAQSNRVDEINTCISCNQACLDHAFARKTVSCLLNPRAGR
MMAR_4276|M.marinum_M PMLSDPEWVLKAQSGRVDEINTCIACNQACLDHVFVKKKVSCLLNPRAGH
MUL_1023|M.ulcerans_Agy99 PMLSDPEWVLKAQSGRVDEINTCIACNQACLDHVFVKKKVSCLLNPRAGH
TH_3970|M.thermoresistible__bu AAIVHHDFARQVLADPAYR-------------------------------
MAV_4324|M.avium_104 PLILLGGITNRETMDLAMAEG-----------------------------
: :
Mflv_1689|M.gilvum_PYR-GCK ------AELNEPDVATFYAPG----PDGYLDYPTLDEMVTPRSA------
MAB_0830|M.abscessus_ATCC_1997 ------AELNEANAATFYSPG----KEGYIDYPSLSAGR-----------
Mvan_4790|M.vanbaalenii_PYR-1 ------LPLAEVDFDTVYGSDVAGYPQGYTDYPTAD--------------
MSMEG_2969|M.smegmatis_MC2_155 ------APLERFDHGMLSPMATIVNAAAWTAARHRERVPR----------
Mb1208c|M.bovis_AF2122/97 ETQLVLSPTRRARSVAVVGAGPAGLATAANAAQRGHRVTLFEANDFIGGQ
Rv1175c|M.tuberculosis_H37Rv ETQLVLSPTRRARSVAVVGAGPAGLATAANAAQRGHRVTLFEANDFIGGQ
MMAR_4276|M.marinum_M ETLLTLSPTQRARTVAVVGAGPAGLAAAVAAAQRGHRVTLFEANDFIGGQ
MUL_1023|M.ulcerans_Agy99 ETLLTMSPTQRARTVAVVGAGPAGLAAAVAAAQRGHRVTLFEANDFIGGQ
TH_3970|M.thermoresistible__bu ------AAPLPVSAEHLAAEAVGPRFVDYLASNWDDFVSTG---------
MAV_4324|M.avium_104 ------FEFVAMARALLAEPDLINRIAADGAAHRVHSACTHCNQCMPTIY
.
Mflv_1689|M.gilvum_PYR-GCK --------------------------------------------------
MAB_0830|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_4790|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_2969|M.smegmatis_MC2_155 --------------------------------------------------
Mb1208c|M.bovis_AF2122/97 FDMARRIPGKEEFSETIRYFSTILAKHGVEVRLGTRVAAQELTGYDEVVL
Rv1175c|M.tuberculosis_H37Rv FDMARRIPGKEEFSETIRYFSTILAKHGVEVRLGTRVAAQELTGYDEVVL
MMAR_4276|M.marinum_M FDLARRIPGKEEFNETIRYFSTMLAKHGVDVRLATRATADELTGYDEVVL
MUL_1023|M.ulcerans_Agy99 FDLARRIPGKEEFNETIRYFSTMLAKHGVDVRLATRATADELTGYDEVVL
TH_3970|M.thermoresistible__bu --------------------------------------------------
MAV_4324|M.avium_104 SRTHCVVTGAPDRHTSAAT-------------------------------
Mflv_1689|M.gilvum_PYR-GCK --------------------------------------------------
MAB_0830|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_4790|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_2969|M.smegmatis_MC2_155 --------------------------------------------------
Mb1208c|M.bovis_AF2122/97 ATGVAPRIPAIPGIDHPMVLTYAEAITGVRPVGRTVAVVGAGGIGFDVTE
Rv1175c|M.tuberculosis_H37Rv ATGVAPRIPAIPGIDHPMVLTYAEAITGVRPVGRTVAVVGAGGIGFDVTE
MMAR_4276|M.marinum_M ATGVAPRIPAIPGIAHAKVLTYTEAITGAKPVGPSVAVVGAGGIGFDVTE
MUL_1023|M.ulcerans_Agy99 ATGVAPRIPAIPGIAHAKVLTYTEAITGAKPVGPSVAVVGAGGIGFDVTE
TH_3970|M.thermoresistible__bu --------------------------------------------------
MAV_4324|M.avium_104 --------------------------------------------------
Mflv_1689|M.gilvum_PYR-GCK --------------------------------------------------
MAB_0830|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_4790|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_2969|M.smegmatis_MC2_155 --------------------------------------------------
Mb1208c|M.bovis_AF2122/97 LLVTDSSPTLNLKEWKAEWGVADPREARGALTTPLPAPPAREVYLLQRTK
Rv1175c|M.tuberculosis_H37Rv LLVTDSSPTLNLKEWKAEWGVADPREARGALTTPLPAPPAREVYLLQRTK
MMAR_4276|M.marinum_M LLITESSPTLNLKEWKAEWGVVDPQEARGALTTALPTPAAREVYLLQRTK
MUL_1023|M.ulcerans_Agy99 LLITESSPTLNLKEWKAEWGVVDPQEARGALTTALPTPAAREVYLLQRTK
TH_3970|M.thermoresistible__bu --------------------------------------------------
MAV_4324|M.avium_104 --------------------------------------------------
Mflv_1689|M.gilvum_PYR-GCK --------------------------------------------------
MAB_0830|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_4790|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_2969|M.smegmatis_MC2_155 --------------------------------------------------
Mb1208c|M.bovis_AF2122/97 GPQGKRLGKTTGWVHRASLKAKGVHQLSGVNYEQINDDGLHISFGPKRRR
Rv1175c|M.tuberculosis_H37Rv GPQGKRLGKTTGWVHRASLKAKGVHQLSGVNYEQINDDGLHISFGPKRRR
MMAR_4276|M.marinum_M GPQGKRLGKTSGWVHRASVKAKGVHQLSGVNYERISDDGLHISFGPERQR
MUL_1023|M.ulcerans_Agy99 GPQGKRLGKTSGWVHRASVKAKGVHQLSGVNYERISDDGLHISFGPDRQR
TH_3970|M.thermoresistible__bu --------------------------------------------------
MAV_4324|M.avium_104 --------------------------------------------------
Mflv_1689|M.gilvum_PYR-GCK --------------------------------------------------
MAB_0830|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_4790|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_2969|M.smegmatis_MC2_155 --------------------------------------------------
Mb1208c|M.bovis_AF2122/97 PQLLAVDNVVVCAGQEPVRDLESELRRHGINPHISGGAAVAAELDAKRAI
Rv1175c|M.tuberculosis_H37Rv PQLLAVDNVVVCAGQEPVRDLESELRRHGINPHIIGGAAVAAELDAKRAI
MMAR_4276|M.marinum_M PQLLAVDSVVICAGQEPVRDLETDLRSNGVDPHIIGGAALAAELDAKRAI
MUL_1023|M.ulcerans_Agy99 PQLLAVDSVVICAGQEPVRDLETDLRSNGVDPHIIGGAALAAELDAKRAI
TH_3970|M.thermoresistible__bu --------------------------------------------------
MAV_4324|M.avium_104 --------------------------------------------------
Mflv_1689|M.gilvum_PYR-GCK ----------
MAB_0830|M.abscessus_ATCC_1997 ----------
Mvan_4790|M.vanbaalenii_PYR-1 ----------
MSMEG_2969|M.smegmatis_MC2_155 ----------
Mb1208c|M.bovis_AF2122/97 KQGTELAARL
Rv1175c|M.tuberculosis_H37Rv KQGTELAARL
MMAR_4276|M.marinum_M KQGTELAARL
MUL_1023|M.ulcerans_Agy99 KQGTELAARL
TH_3970|M.thermoresistible__bu ----------
MAV_4324|M.avium_104 ----------