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VSRPTPDVFDPGTLGPVTLRNRIIKAATFEARTPAGAVTDELIEYHRAPAAGGVGMTTVAYCAVSPEGRT ERDQILMTPEAVPALVRLTDAVRSEGAAVCAQLGHAGPVANAASNGLPAFSPSRMFSPLAMKATRQPDAA EIARIVADHARAADLAGQAGFDAVELHFGHNYLVSSFFSPLLNRRRDSYGGSLANRARLAREIAVAVRES VGDQIAVTAKLNMDDGVPGGLRLEESLQIGRWLQDDGALDALQLTVGSSLLNPMYYFRGQAPRDDFARVF PRPLNWALLTAGRFFLRQYPFEEAYLLESARQFRHELSMPLILLGGITTRDTMDQAMAEGFEYVAMARAL LRDPGLVGRIRSDPTTRSLCTHCNKCMVTIFEKTRCVLHPLPAADNPSAERAAVHAELFA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_2881 | - | - | 100% (410) | NADH:flavin oxidoreductase/NADH oxidase |
| M. vanbaalenii PYR-1 | Mvan_1549 | - | e-141 | 62.57% (382) | NADH:flavin oxidoreductase/NADH oxidase |
| M. vanbaalenii PYR-1 | Mvan_2887 | - | e-112 | 54.78% (387) | NADH:flavin oxidoreductase/NADH oxidase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3394 | - | 1e-139 | 62.11% (388) | oxidoreductase |
| M. gilvum PYR-GCK | Mflv_4880 | - | 1e-141 | 63.25% (381) | NADH:flavin oxidoreductase/NADH oxidase |
| M. tuberculosis H37Rv | Rv3359 | - | 1e-139 | 62.11% (388) | oxidoreductase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_3694 | - | 1e-141 | 63.45% (383) | oxidoreductase |
| M. marinum M | MMAR_1175 | - | 1e-137 | 61.17% (394) | oxidoreductase |
| M. avium 104 | MAV_4324 | - | 1e-139 | 62.60% (393) | oxidoreductase, FAD/FMN-binding superfamily protein |
| M. smegmatis MC2 155 | MSMEG_1645 | - | 1e-139 | 62.44% (394) | NADH:flavin oxidoreductase/NADH oxidase |
| M. thermoresistible (build 8) | TH_1966 | - | 1e-143 | 64.34% (387) | POSSIBLE OXIDOREDUCTASE |
| M. ulcerans Agy99 | MUL_1023 | fadH | 3e-28 | 27.02% (396) | NADPH dependent 2,4-dienoyl-CoA reductase FadH |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_1175|M.marinum_M ---MSP---------TPDVLSPAQLGPLTLRNRVIKAATFEARTPNALVT
MAV_4324|M.avium_104 ---MPT---------PPDVFSPAKLGPITLRNRIIKSATFEARTPDALVT
Mb3394|M.bovis_AF2122/97 ---MAPGS-----CEAPDVFNPAKLGPLTLRNRVIKAATFEARTPDALVT
Rv3359|M.tuberculosis_H37Rv ---MAPGS-----CEAPDVFNPAKLGPLTLRNRVIKAATFEARTPDALVT
Mflv_4880|M.gilvum_PYR-GCK MLSIPPRGKLGDMTVPHDVFSPAKLGPLTLRNRIIKAATFEASTPNALVT
TH_1966|M.thermoresistible__bu ------------------VFAPAKLGPLTLRNRIIKAATFEARTPDALVT
MSMEG_1645|M.smegmatis_MC2_155 -MNTQPN-------VFTDVFSEAKLGPITLRNRIIKAATFEASTPDALVT
MAB_3694|M.abscessus_ATCC_1997 -MGSDAAG-------IPDVLAPARLGPITLRNRTIKAATFEAASPDAFVT
Mvan_2881|M.vanbaalenii_PYR-1 --MSRP---------TPDVFDPGTLGPVTLRNRIIKAATFEARTPAGAVT
MUL_1023|M.ulcerans_Agy99 --MTSP---------YPNLLFPLDLGFTTLRNRVVMGSMHTGLEDRPKDT
:: ** ***** : .: . . *
MMAR_1175|M.marinum_M DDLIEYHRQPAAGGIAMTTVA-YCAVSPGGRTSGEQIWMRREAVPGLRRL
MAV_4324|M.avium_104 DDLIEYHRLPAAGGVGMTTVA-YCAVSPGGRTEGNGIWMRPEAVPGFRRL
Mb3394|M.bovis_AF2122/97 DDLIEYHRLPAAGGVAMTTVA-YCAVSPGGRTGGNQIWMRPHAVPGLRRL
Rv3359|M.tuberculosis_H37Rv DDLIEYHRLPAAGGVAMTTVA-YCAVSPGGRTGGNQIWMRPHAVPGLRRL
Mflv_4880|M.gilvum_PYR-GCK EDLITYHRLPAAGGVGMTTVA-YCAVAPGGRTDGWQLWMRPEAVPGLRRL
TH_1966|M.thermoresistible__bu DDLIEYHRLPAAGGVGMTTVA-YCAVSPGGRTDGWQLWMRPEAVPGLRRL
MSMEG_1645|M.smegmatis_MC2_155 EDLINYHRLPAAGGVGMTTVA-YCAVAPGGRTDGWQIWMRPEAVPGLQKL
MAB_3694|M.abscessus_ATCC_1997 DDLIEYHRRPALGGVGMTTVA-YCAVAPEGRTEYGQVWMREEAIPGLRRL
Mvan_2881|M.vanbaalenii_PYR-1 DELIEYHRAPAAGGVGMTTVA-YCAVSPEGRTERDQILMTPEAVPALVRL
MUL_1023|M.ulcerans_Agy99 DRLAEYFAERARGGVGMLITGGYAPNRTGWLYPFASELVTPAEARRHRRI
: * *. * **:.* .. *.. . : ::
MMAR_1175|M.marinum_M TEAIHAEGAAVSAQIGHAGPVADARSNKATALAPVRFFNPIAMRFAKRAT
MAV_4324|M.avium_104 TDAIHAEGAAVSAQIGHAGPVANARSNKAHALAPVRFFNPIGMRFAKKAT
Mb3394|M.bovis_AF2122/97 TEAIHAEGAAISAQIGHAGPVADARSNQATALAPVRFFNPIAMRFAQKAT
Rv3359|M.tuberculosis_H37Rv TEAIHAEGAAISAQIGHAGPVADARSNQATALAPVRFFNPIAMRFAQKAT
Mflv_4880|M.gilvum_PYR-GCK TDAVHAEGAAISAQIGHAGPVANARTNKATALAPVRFFNPLSMRFARKAT
TH_1966|M.thermoresistible__bu TDAVHAEGAAVSAQIGHAGPVANARTNKAQALAPIRFFNPLSMRFARKAT
MSMEG_1645|M.smegmatis_MC2_155 TEAVHAEGAAISAQIGHAGPVANARTNKAKALAPVRFFNPLSMRFAKKAT
MAB_3694|M.abscessus_ATCC_1997 TDAIHDTGAAVSAQIGHAGPVANARSNGSPALSPIRFFNPLGMKFARRAS
Mvan_2881|M.vanbaalenii_PYR-1 TDAVRSEGAAVCAQLGHAGPVANAASNGLPAFSPSRMFSPLAMKATRQPD
MUL_1023|M.ulcerans_Agy99 TGAVHDADAKILLQVLHAG----RYAYHPLSVSASSIKAPINPFRSRKLT
* *:: .* : *: *** : :.:. : *: :::
MMAR_1175|M.marinum_M RDDIDDVLAAHANAARLAVEAGFDAVEIHLGHNYLASSFLSPLINRRADE
MAV_4324|M.avium_104 REDIDEVIAAHANAARLAIEAGFDAVEIHLGHNYLASSFLSPLINRRNDE
Mb3394|M.bovis_AF2122/97 REDIDDVLAAHAHAARLAVDAGFDAVEIHLGHNYLASAFLSPLLNRRDDE
Rv3359|M.tuberculosis_H37Rv REDIDDVLAAHAHAARLAVDAGFDAVEIHLGHNYLASAFLSPLLNRRDDE
Mflv_4880|M.gilvum_PYR-GCK ADDIREVTEAHANAARLAIDSGFDAVEIHLGHNYLASSFLSPLINRRTDE
TH_1966|M.thermoresistible__bu REDIREVTEAHATAAKLAVDAGFDAVEIHLGHNYLASSFLSPLLNRRTDE
MSMEG_1645|M.smegmatis_MC2_155 IDDIREVTAAHANAARLAIDSGFDAVEIHLGHNYLASSFLSPLINRRIDE
MAB_3694|M.abscessus_ATCC_1997 ASDIDGVIAAHANAARLAIEAGFDAVEIHLGHGYFVSSFLSPLFNRRGDE
Mvan_2881|M.vanbaalenii_PYR-1 AAEIARIVADHARAADLAGQAGFDAVELHFGHNYLVSSFFSPLLNRRRDS
MUL_1023|M.ulcerans_Agy99 SRGVEATIADFARCAQLAQEAGYDGVEIMGSEGYLLNQFLAPRTNQRTDS
: .* .* ** ::*:*.**: ...*: . *::* *:* *.
MMAR_1175|M.marinum_M FGGSLENRAKVARGLVRAVRGALDKDGISHVAVTAKLNMADGVRGGISTE
MAV_4324|M.avium_104 FGGSLQNRAKVARGMVMAVRRAVEKEGTP-IAVTAKLNMADGVRGGISTE
Mb3394|M.bovis_AF2122/97 FGGSLQNRAKVARGLVMAVRRAVR----QQVAVTAKLNMTDGIRGGITVD
Rv3359|M.tuberculosis_H37Rv FGGSLQNRAKVARGLVMAVRRAVR----QQVAVTAKLNMTDGIRGGITVD
Mflv_4880|M.gilvum_PYR-GCK FGGSLANRAKVARGAVLAVKEAV----GDRIAVTAKLNMSDGVRGGISIE
TH_1966|M.thermoresistible__bu FGGSLENRAKVARGLVQAVKRAV----GDQIAVTAKLNMSDGVRGGITIE
MSMEG_1645|M.smegmatis_MC2_155 FGGSLENRAKVARGVVRAVRDAVDK-AGGTIAVTAKLNMSDGIRGGISLE
MAB_3694|M.abscessus_ATCC_1997 YGGSLANRAKVARAVVQAVRKVAG----SRLAVTAKLTMTDGIRGGIPIE
Mvan_2881|M.vanbaalenii_PYR-1 YGGSLANRARLAREIAVAVRESVG----DQIAVTAKLNMDDGVPGGLRLE
MUL_1023|M.ulcerans_Agy99 WGGTPAKRRRFPVEIVRRTRAAVG----PDFIICYRMSMADYVEGGQSWD
:**: :* :.. . .: . : ::.* * : ** :
MMAR_1175|M.marinum_M ESLRTAKWLEEDGG-----------------------------LDAIELT
MAV_4324|M.avium_104 ESLTTAKWLESDGG-----------------------------LDAIELT
Mb3394|M.bovis_AF2122/97 EALTTARWLQDDGG-----------------------------LDAIELT
Rv3359|M.tuberculosis_H37Rv EALTTARWLQDDGG-----------------------------LDAIELT
Mflv_4880|M.gilvum_PYR-GCK ESLQTAKWLEEDGG-----------------------------LDAIELT
TH_1966|M.thermoresistible__bu ESLQTAKWLEEDGG-----------------------------LDAIQLT
MSMEG_1645|M.smegmatis_MC2_155 ESLQTAKWLEEDGG-----------------------------LDAIELT
MAB_3694|M.abscessus_ATCC_1997 ESLQTATWLQEDGG-----------------------------LDALELT
Mvan_2881|M.vanbaalenii_PYR-1 ESLQIGRWLQDDGA-----------------------------LDALQLT
MUL_1023|M.ulcerans_Agy99 EIVALATELESAGATIINSGFGWHEARIPTIVTSVPSGAFVEISNAVAEQ
* : . *:. *. :*:
MMAR_1175|M.marinum_M AGSSLVNP----------MYLFRGDAPVKEFAAAFKPPMRWGVRMMG---
MAV_4324|M.avium_104 AGSSLVNP----------MYLFRGDAPLKEFAGAFKPPLRWGMRMTG---
Mb3394|M.bovis_AF2122/97 AGSSLVNP----------MYLFRGDAPVKEFAAAFKPPLRWGIRMTG---
Rv3359|M.tuberculosis_H37Rv AGSSLVNP----------MYLFRGDAPVKEFAAAFKPPLRWGIRMTG---
Mflv_4880|M.gilvum_PYR-GCK AGSSLLNP----------MFLFRGGAPIKEFARNFKPPLSWGMRMTG---
TH_1966|M.thermoresistible__bu AGSSLVNP----------MYLFRGGAPVKEFAGAFKPPLSWGIRMTG---
MSMEG_1645|M.smegmatis_MC2_155 AGSSLVNP----------MYLFRGDAPVKEFAGAFKPPISWGMRTVG---
MAB_3694|M.abscessus_ATCC_1997 AGSSLVNP----------MYLFRGDVPIRELAKGFPKPMGWGVRLTG---
Mvan_2881|M.vanbaalenii_PYR-1 VGSSLLNP----------MYYFRGQAPRDDFARVFPRPLNWALLTAG---
MUL_1023|M.ulcerans_Agy99 VSIPVMTSNRINMPQAAEQILADTDVALISMARPMLSDPEWVLKAQSGRV
.. .::.. .. .:* : * : .
MMAR_1175|M.marinum_M ---------------------------------KKFLREYPYR-------
MAV_4324|M.avium_104 ---------------------------------KKFLREYPYR-------
Mb3394|M.bovis_AF2122/97 ---------------------------------HRFFREYPYR-------
Rv3359|M.tuberculosis_H37Rv ---------------------------------HRFFREYPYR-------
Mflv_4880|M.gilvum_PYR-GCK ---------------------------------KKFMREYPYE-------
TH_1966|M.thermoresistible__bu ---------------------------------TKFFREYPYH-------
MSMEG_1645|M.smegmatis_MC2_155 ---------------------------------KGFLREYPYR-------
MAB_3694|M.abscessus_ATCC_1997 ---------------------------------KKFFRSYPYH-------
Mvan_2881|M.vanbaalenii_PYR-1 ---------------------------------RFFLRQYPFE-------
MUL_1023|M.ulcerans_Agy99 DEINTCIACNQACLDHVFVKKKVSCLLNPRAGHETLLTMSPTQRARTVAV
:: * .
MMAR_1175|M.marinum_M --------DAYLLRDARLFRSELSMPLILLGGITNRETMDLAMAEGFEFV
MAV_4324|M.avium_104 --------EAYLLRDAKLFRAELKMPLILLGGITNRETMDLAMAEGFEFV
Mb3394|M.bovis_AF2122/97 --------DAYLLREARLFRAELTIPLILLGGITNRTTMDLAMAEGFEFV
Rv3359|M.tuberculosis_H37Rv --------DAYLLREARLFRAELTIPLILLGGITNRTTMDLAMAEGFEFV
Mflv_4880|M.gilvum_PYR-GCK --------EAYLMRDAKKFRDELTMPIILLGGITNRETMDRAMAEGFDFV
TH_1966|M.thermoresistible__bu --------DAYLLRDARQFRAELTMPLILLGGITNRETMDRAMAEGFDFV
MSMEG_1645|M.smegmatis_MC2_155 --------EAYLLREAKQFRAELKLPLILLGGITNRDTMDQAMAEGFEFV
MAB_3694|M.abscessus_ATCC_1997 --------DAFLLEDARRFRAELDIPLILLGGITGGESMDLAMAEGFEFV
Mvan_2881|M.vanbaalenii_PYR-1 --------EAYLLESARQFRHELSMPLILLGGITTRDTMDQAMAEGFEYV
MUL_1023|M.ulcerans_Agy99 VGAGPAGLAAAVAAAQRGHRVTLFEANDFIGGQFDLARRIPGKEEFNETI
* : : .* * . ::** . * : :
MMAR_1175|M.marinum_M AMARALLAEP----DLINRIAAEG---NRVHSACTHCNQCMPTIYSRTRC
MAV_4324|M.avium_104 AMARALLAEP----DLINRIAADGAA-HRVHSACTHCNQCMPTIYSRTHC
Mb3394|M.bovis_AF2122/97 AMARALLAEP----DLVNRIAAEG---SQVRSACTHCNQCMATIYRRTHC
Rv3359|M.tuberculosis_H37Rv AMARALLAEP----DLVNRIAAEG---SQVRSACTHCNQCMATIYRRTHC
Mflv_4880|M.gilvum_PYR-GCK AMGRALLAEP----DLLNRIRAD----SSVKSICDHCNLCMPTIYNHTYC
TH_1966|M.thermoresistible__bu AMGRALLAEP----DLLNRIKAD----PGVQSICDHCNLCMPTIYSHTLC
MSMEG_1645|M.smegmatis_MC2_155 AMGRALLAEP----DLINRIKADGDA-HSVRSLCTHCNKCMPTIYTHTHC
MAB_3694|M.abscessus_ATCC_1997 AMGRALLADP----DLVNRVAADR----ASHSRCTHCNQCMATIFSKTHC
Mvan_2881|M.vanbaalenii_PYR-1 AMARALLRDP----GLVGRIRSDP----TTRSLCTHCNKCMVTIFEKTRC
MUL_1023|M.ulcerans_Agy99 RYFSTMLAKHGVDVRLATRATADELTGYDEVVLATGVAPRIPAIPGIAHA
::* . * * :: . : :* : .
MMAR_1175|M.marinum_M VVTGAPD-------------------------------------------
MAV_4324|M.avium_104 VVTGAPDRHTSAAT------------------------------------
Mb3394|M.bovis_AF2122/97 VVTGAP--------------------------------------------
Rv3359|M.tuberculosis_H37Rv VVTGAP--------------------------------------------
Mflv_4880|M.gilvum_PYR-GCK VRTGSP-SPVSSGR------------------------------------
TH_1966|M.thermoresistible__bu VRTGMPDAAVKAGG------------------------------------
MSMEG_1645|M.smegmatis_MC2_155 VLTGAPDALVR---------------------------------------
MAB_3694|M.abscessus_ATCC_1997 VLT-----------------------------------------------
Mvan_2881|M.vanbaalenii_PYR-1 VLHPLPAADNPSAERAAVHAELFA--------------------------
MUL_1023|M.ulcerans_Agy99 KVLTYTEAITGAKPVGPSVAVVGAGGIGFDVTELLITESSPTLNLKEWKA
MMAR_1175|M.marinum_M --------------------------------------------------
MAV_4324|M.avium_104 --------------------------------------------------
Mb3394|M.bovis_AF2122/97 --------------------------------------------------
Rv3359|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_4880|M.gilvum_PYR-GCK --------------------------------------------------
TH_1966|M.thermoresistible__bu --------------------------------------------------
MSMEG_1645|M.smegmatis_MC2_155 --------------------------------------------------
MAB_3694|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_2881|M.vanbaalenii_PYR-1 --------------------------------------------------
MUL_1023|M.ulcerans_Agy99 EWGVVDPQEARGALTTALPTPAAREVYLLQRTKGPQGKRLGKTSGWVHRA
MMAR_1175|M.marinum_M --------------------------------------------------
MAV_4324|M.avium_104 --------------------------------------------------
Mb3394|M.bovis_AF2122/97 --------------------------------------------------
Rv3359|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_4880|M.gilvum_PYR-GCK --------------------------------------------------
TH_1966|M.thermoresistible__bu --------------------------------------------------
MSMEG_1645|M.smegmatis_MC2_155 --------------------------------------------------
MAB_3694|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_2881|M.vanbaalenii_PYR-1 --------------------------------------------------
MUL_1023|M.ulcerans_Agy99 SVKAKGVHQLSGVNYERISDDGLHISFGPDRQRPQLLAVDSVVICAGQEP
MMAR_1175|M.marinum_M -------------------------------------------
MAV_4324|M.avium_104 -------------------------------------------
Mb3394|M.bovis_AF2122/97 -------------------------------------------
Rv3359|M.tuberculosis_H37Rv -------------------------------------------
Mflv_4880|M.gilvum_PYR-GCK -------------------------------------------
TH_1966|M.thermoresistible__bu -------------------------------------------
MSMEG_1645|M.smegmatis_MC2_155 -------------------------------------------
MAB_3694|M.abscessus_ATCC_1997 -------------------------------------------
Mvan_2881|M.vanbaalenii_PYR-1 -------------------------------------------
MUL_1023|M.ulcerans_Agy99 VRDLETDLRSNGVDPHIIGGAALAAELDAKRAIKQGTELAARL