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M. thermoresistible (build 8) TH_1371 (-)

annotation: cystathionine beta-synthase
coordinates: 2602064 - 2603470
length: 469

aa seq not available

Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. thermoresistible (build 8)TH_1371--100% (469)cystathionine beta-synthase
M. thermoresistible (build 8)TH_1449cysK8e-6444.22% (303) PROBABLE CYSTEINE SYNTHASE A CYSK1 (O-ACETYLSERINE
M. thermoresistible (build 8)TH_4143-2e-4738.24% (306) PUTATIVE cysteine synthase

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb1106cbs0.082.72% (463) cystathionine beta-synthase CBS (Serine sulfhydrase)
M. gilvum PYR-GCKMflv_2043-0.085.90% (468) cystathionine beta-synthase
M. tuberculosis H37RvRv1077cbs0.082.72% (463) cystathionine beta-synthase CBS (Serine sulfhydrase)
M. leprae Br4923MLBr_02396cysM20.079.70% (463) cystathionine beta-synthase
M. abscessus ATCC 19977MAB_1195-0.084.42% (462) cystathionine beta-synthase
M. marinum MMMAR_4390cbs0.081.43% (463) cystathionine beta-synthase CBS
M. avium 104MAV_1201-0.082.72% (463) cystathionine beta-synthase
M. smegmatis MC2 155MSMEG_5270-0.086.97% (468) cystathionine beta-synthase
M. ulcerans Agy99MUL_0203cbs0.080.99% (463) cystathionine beta-synthase CBS
M. vanbaalenii PYR-1Mvan_4674-0.086.27% (466) cystathionine beta-synthase

CLUSTAL 2.0.9 multiple sequence alignment


MMAR_4390|M.marinum_M               MRIAQHISDLIGGTPLVRLNAVVPAGIGTVAAKVEYLNPGGSSKDRIAIK
MUL_0203|M.ulcerans_Agy99           MRIAQHISDLIGGTPLVRLNAVVPAGIGTVAAKVEYLNPGGSSKDRIAIK
MAV_1201|M.avium_104                MRIAQHISDLIGGTPLVRLNSVVPDGAGIVAAKVEYLNPGGSSKDRIAVR
Mb1106|M.bovis_AF2122/97            MRIAQHISELIGGTPLVRLNSVVPDGAGTVAAKVEYLNPGGSSKDRIAVK
Rv1077|M.tuberculosis_H37Rv         MRIAQHISELIGGTPLVRLNSVVPDGAGTVAAKVEYLNPGGSSKDRIAVK
MLBr_02396|M.leprae_Br4923          MRIAQHISDLIGGTPLVRLNSVVPAGTGVVAAKVEYFNSGGSSKDRIAAK
TH_1371|M.thermoresistible__bu      MRYARHVSELIGNTPLVQLNSVVPEGAGMVLAKIEYLNPGGSSKDRIAVK
MSMEG_5270|M.smegmatis_MC2_155      MRIARHISELIGNTPLVQLNSVVPEGAGLVAAKIEYLNPGGSSKDRIALK
Mflv_2043|M.gilvum_PYR-GCK          MRIARHISELIGNTPLVQLNSVVPPGAGTVVAKVEYLNPGGSSKDRIAIK
Mvan_4674|M.vanbaalenii_PYR-1       MRIARHISELIGNTPLVQLNSVVPPGAGTVAAKIEYLNPGGSSKDRIAIK
MAB_1195|M.abscessus_ATCC_1997      MRIAQHVSDLIGNTPLVRLNSVVPEGCATVAAKIEYLNPGGSSKDRIAVK
                                    ** *:*:*:***.****:**:*** * . * **:**:*.********* :

MMAR_4390|M.marinum_M               MIDAAEASGALRPGGTIVEPTSGNTGVGLALVAQHRGYKCVFVCPDKVSE
MUL_0203|M.ulcerans_Agy99           MIDAAEASGALRPGGTIVEPTSGNTGVGLALVAQHRGYKCVFVCPDKVSE
MAV_1201|M.avium_104                MIDAAEASGALKPGGTIVEPTSGNTGVGLALVAQQRGYKCVFVCPDKVGE
Mb1106|M.bovis_AF2122/97            MIEAAEASGQLKPGGTIVEPTSGNTGVGLALVAQRRGYKCVFVCPDKVSE
Rv1077|M.tuberculosis_H37Rv         MIEAAEASGQLKPGGTIVEPTSGNTGVGLALVAQRRGYKCVFVCPDKVSE
MLBr_02396|M.leprae_Br4923          MIDAAEASGQLKPGGTIVEPTSGNTGVGLALVAQHRGYKCVFVCPDKVSE
TH_1371|M.thermoresistible__bu      MIEDAEKRGLLKPGGTIVEPTSGNTGVGLAIVAQQRGYKCIFVCPDKVSE
MSMEG_5270|M.smegmatis_MC2_155      MIEAAEVSGELKPGGTIVEPTSGNTGVGLALVAQQRGYKCVFVCPDKVSE
Mflv_2043|M.gilvum_PYR-GCK          MIDAAEASGELKPGGTIVEPTSGNTGVGLAIVAQQRGYKCIFVCPDKVSE
Mvan_4674|M.vanbaalenii_PYR-1       MIDAAEASGELKPGGTIVEPTSGNTGVGLAIVAQQRGYKCIFVCPDKVSE
MAB_1195|M.abscessus_ATCC_1997      MIEAAEEAGLLKPGGTIVEPTSGNTGVGLALVAQRKGYHCVFVCPDKVSE
                                    **: **  * *:******************:***::**:*:*******.*

MMAR_4390|M.marinum_M               DKRNVLRAYGAEVVVCPTAVPPEDPDSYYSVSDRLVREIDGAWKPDQYAN
MUL_0203|M.ulcerans_Agy99           DKRNVLRAYGAEVVVCPTAVPPEDPDSYYSVSDRLVREIDGAWKPDQYAN
MAV_1201|M.avium_104                DKRNVLMAYGAEVVVCPTAVPPEHPDSYYSVSDRLVTEIEGAWKPDQYAN
Mb1106|M.bovis_AF2122/97            DKRNVLIAYGAEVVVCPTAVPPHDPASYYSVSDRLVRDIDGAWKPDQYAN
Rv1077|M.tuberculosis_H37Rv         DKRNVLIAYGAEVVVCPTAVPPHDPASYYSVSDRLVRDIDGAWKPDQYAN
MLBr_02396|M.leprae_Br4923          DKRNVLLAYGAEVVVCPTAVPPDDPDSYYSVSDRLVAKIDGAWKPDQYAN
TH_1371|M.thermoresistible__bu      DKQNVLRAYGAEVVVCPTAVPPEHPDSYYSVSDRLTREIDGAWKPDQYSN
MSMEG_5270|M.smegmatis_MC2_155      DKRNVLRAYGAEVVVCPTAVPPDHPDSYYSVSNRLVTEIEGAWKPDQYSN
Mflv_2043|M.gilvum_PYR-GCK          DKQNVLRAYGAEVVVCPTAVAPDDPASYYSVSNRLVSEIDGAWKPDQYSN
Mvan_4674|M.vanbaalenii_PYR-1       DKQNVLRAYGADVVVCPTAVAPEDPASYYSVSNRLVEEIDGAWKPDQYSN
MAB_1195|M.abscessus_ATCC_1997      DKRNVLRAYGAEVVVCPTAVPPEHPDSYYNVSDRLVREIEGAWKPDQYSN
                                    **:*** ****:********.*..* ***.**:**. .*:********:*

MMAR_4390|M.marinum_M               PEGPASHYATTGPEIWADTDGKITHFVAGIGTGGTITGAGRYLKEVSG--
MUL_0203|M.ulcerans_Agy99           PEGPASHYATTGPEIWADTDGKITHFVAGIGTGGTITGAGCYLKEVSG--
MAV_1201|M.avium_104                PEGPASHYATTGPEIWADTDGKVTHFVAGIGTGGTITGAGRYLKEVSG--
Mb1106|M.bovis_AF2122/97            PEGPASHYVTTGPEIWADTEGKVTHFVAGIGTGGTITGAGRYLKEVSG--
Rv1077|M.tuberculosis_H37Rv         PEGPASHYVTTGPEIWADTEGKVTHFVAGIGTGGTITGAGRYLKEVSG--
MLBr_02396|M.leprae_Br4923          PAGPASHYETTGPEIWADTDGRVTHFVAGIGTGGTITGVGRYLKEVSG--
TH_1371|M.thermoresistible__bu      QMGPQSHYETTGPEIWNDTDGKVTHFVAGVGTGGTITGAGRYLKEVSGRR
MSMEG_5270|M.smegmatis_MC2_155      QMGPESHYETTGPEIWADTEGKITHFVAGVGTGGTITGTGRYLKEVSG--
Mflv_2043|M.gilvum_PYR-GCK          PMGPESHYETTGPEIWADTDGKITHFVAGVGTGGTITGAGRYLKEVSG--
Mvan_4674|M.vanbaalenii_PYR-1       PMGPESHYETTGPEIWADTDGKVTHFVAGVGTGGTITGAGRYLKEVSG--
MAB_1195|M.abscessus_ATCC_1997      PNGPASHYETTGPEIWADTDGKITHFVAGVGTGGTITGAGRYLKEVSGGR
                                      ** *** ******* **:*::******:********.* *******  

MMAR_4390|M.marinum_M               --GKVRVIGADPEGSVYSGGTGRPYLVEGVGEDFWPAAYDPAVPDEIIAV
MUL_0203|M.ulcerans_Agy99           --GKVRVIGADPEGSVYSGGTGRPYLVEGVGEDFWPATYDHAVPDEIIAV
MAV_1201|M.avium_104                --GRVRVIGADPEGSVYSGGTGRPYLVEGVGEDFWPQAYDRTVPDEIIAV
Mb1106|M.bovis_AF2122/97            --GRVRIVGADPEGSVYSGGAGRPYLVEGVGEDFWPAAYDPSVPDEIIAV
Rv1077|M.tuberculosis_H37Rv         --GRVRIVGADPEGSVYSGGAGRPYLVEGVGEDFWPAAYDPSVPDEIIAV
MLBr_02396|M.leprae_Br4923          --GLVRIIGADPEGSVYSGGTGRPYLVEGVGEDFWPAAYDPMVPDQIIAV
TH_1371|M.thermoresistible__bu      PEGPVRVVGADPEGSVYSGGTGRPYLVEGVGEDFWPSVYDPSVPDEIIAV
MSMEG_5270|M.smegmatis_MC2_155      --GKVKVIGADPEGSVYSGGTGRPYLVEGVGEDFWPTAYDPSVPDEIIAV
Mflv_2043|M.gilvum_PYR-GCK          --GRVKVIGADPEGSVYSGGTGRPYLVEGVGEDFWPSAYDPSVPDEIIAV
Mvan_4674|M.vanbaalenii_PYR-1       --GRVKVIGVDPEGSVYSGGTGRPYLVEGVGEDFWPAAYDPSVPDEIIAV
MAB_1195|M.abscessus_ATCC_1997      AIGEVKIVGADPEGSVYSGGTGRPYLVEGVGEDFWPSAYDPSVVDEVIAV
                                      * *:::*.**********:*************** .**  * *::***

MMAR_4390|M.marinum_M               SDSDSFDMTRRLAREEAMLVGGSCGMAVVAALRVAEQAGPDALVVVLLPD
MUL_0203|M.ulcerans_Agy99           SDSDSFDMTRRLAREEAMLVGGSCGMAVVAALRVAEQAGPDALVVVLLPD
MAV_1201|M.avium_104                SDSDSFNMTRRLAREEAMLVGGSCGMAVVAALRVAEQAGPDALVVVLLPD
Mb1106|M.bovis_AF2122/97            SDSDSFDMTRRLAREEAMLVGGSCGMAVVAALKVAEEAGPDALIVVLLPD
Rv1077|M.tuberculosis_H37Rv         SDSDSFDMTRRLAREEAMLVGGSCGMAVVAALKVAEEAGPDALIVVLLPD
MLBr_02396|M.leprae_Br4923          SDSDSFNMTRRLAREEAMLVGGSCGMAVVAALQVAEEAGPAALVVVLLPD
TH_1371|M.thermoresistible__bu      SDADSFEMTRRLAREEGLLVGGSCGMAVVAANKVALEAGPDAVVVVLLPD
MSMEG_5270|M.smegmatis_MC2_155      SDADSFEMTRRLAREEALLVGGSCGMAVVAAIEVARKAGPDAVVVVLLPD
Mflv_2043|M.gilvum_PYR-GCK          SDADSFDMTRRLAREEALLVGGSCGMAAVAAIRVAEREGPDALVVVLLPD
Mvan_4674|M.vanbaalenii_PYR-1       SDADSFDMTRRLAREEALLVGGSCGMAAVAAIKVAEREGPDALVVVLLPD
MAB_1195|M.abscessus_ATCC_1997      SDADSFEMTRRLAREEGLLVGGSCGMAVVAAIRLAEKVGPDGLVVVLLPD
                                    **:***:*********.:*********.*** .:* . ** .::******

MMAR_4390|M.marinum_M               GGRGYMSKIFNDAWMSSYGFLRSRLDGRTDASTVGDVLRRKSGALPALVH
MUL_0203|M.ulcerans_Agy99           GGRGYMSKIFNDAWMSSYGFLRSRLDGRTDTSTVGDVLRRKSGALPALVH
MAV_1201|M.avium_104                GGRGYMAKIFNDAWMSSYGFLRTRLDGSTDQSRVGDVLRRKSGELPDLVH
Mb1106|M.bovis_AF2122/97            GGRGYMSKIFNDAWMSSYGFLRSRLDGSTEQSTVGDVLRRKSGALPALVH
Rv1077|M.tuberculosis_H37Rv         GGRGYMSKIFNDAWMSSYGFLRSRLDGSTEQSTVGDVLRRKSGALPALVH
MLBr_02396|M.leprae_Br4923          GGRGYMSKIFNDAWMSSYGFLRSRLDGSTEQPIVGDVLRRKSGALPDLVH
TH_1371|M.thermoresistible__bu      GGRGYLSKIFNDEWMSSYGFLRTPLDGKVHQPTVGDVLRGKSGELPDLVH
MSMEG_5270|M.smegmatis_MC2_155      GGRGYLSKIFNDAWMSSYGFLRTRLDGSVEK-TVGDVLRGKSGALPDLVH
Mflv_2043|M.gilvum_PYR-GCK          GGRGYLSKIFNDGWMSSYGFLRTRLDGSVQESTVGDVLRGKSGALPALVH
Mvan_4674|M.vanbaalenii_PYR-1       GGRGYLSKIFNDAWMSSYGFLRSRLDGSVEESTVGDVLRGKSGALPDLVH
MAB_1195|M.abscessus_ATCC_1997      GGRGYLSKVFNDAWMSSYGFLRSRLDGSVSEPTVGDVLRGKSGALPDLVH
                                    *****::*:*** *********: *** .    ****** *** ** ***

MMAR_4390|M.marinum_M               THPSETVRDAIGILREYGVSQMPVVGAEPPVMAGEVAGSVSERELLSAVF
MUL_0203|M.ulcerans_Agy99           THPSETVRDAIGILREYGVSQMPVVGAEPPVMAGEVAGSVSERELLSAVF
MAV_1201|M.avium_104                THPSETVRDAIGILREYGVSQMPVVGAEPPVMAGEVAGSVSERELLSAVF
Mb1106|M.bovis_AF2122/97            THPSETVRDAIGILREYGVSQMPVVGAEPPVMAGEVAGSVSERELLSAVF
Rv1077|M.tuberculosis_H37Rv         THPSETVRDAIGILREYGVSQMPVVGAEPPVMAGEVAGSVSERELLSAVF
MLBr_02396|M.leprae_Br4923          THPSETVRDAIGILREYAVSQIPVVGAEPPVMAGEVVGSVSERELLSAVF
TH_1371|M.thermoresistible__bu      THPSETIRDAINILREYGVSQMPVVGAEPPVMAGEVAGSVTERELLSAVY
MSMEG_5270|M.smegmatis_MC2_155      THPSETVRDAIGILREYGVSQMPVVGAEPPVMAGEVAGSVSERELLSAVF
Mflv_2043|M.gilvum_PYR-GCK          THPSETVRDAIGILREYGVSQMPVVGAEPPVMAGEVAGSVSERDLVSAVF
Mvan_4674|M.vanbaalenii_PYR-1       THPSETVRDAIGILREYGVSQMPVVGAEPPVMAGEVAGSVSERELLSAVF
MAB_1195|M.abscessus_ATCC_1997      THPSETVRDAIEILREYGVSQMPVVGAEPPVMAGEVAGSVSERELLSAVF
                                    ******:**** *****.***:**************.***:**:*:***:

MMAR_4390|M.marinum_M               SGKAKLADAVSQHMSPPLKLIGAGELVGVAGKALRDWDALMVVEEGKPVG
MUL_0203|M.ulcerans_Agy99           SGKAKLADAVSQHMSPPLKLIGAGELVGVAGKALRDWDALMVVEEGKPVG
MAV_1201|M.avium_104                EGRAKLADAVSLHMSPPLPMIGAGESVSAAGKALRDWDALMVVEEGKPVG
Mb1106|M.bovis_AF2122/97            EGRAKLADAVSAHMSPPLRMIGAGELVSAAGKALRDWDALMVVEEGKPVG
Rv1077|M.tuberculosis_H37Rv         EGRAKLADAVSAHMSPPLRMIGAGELVSAAGKALRDWDALMVVEEGKPVG
MLBr_02396|M.leprae_Br4923          EGRASLADAVSEHMGPPLRLIGDGELVSVAGEALRDSDALMVVEKGKLVG
TH_1371|M.thermoresistible__bu      EGRAKLTDAVAEHMGAPLPLIGAGEPVQAAAKMLRECDAVMVVEEGKPAG
MSMEG_5270|M.smegmatis_MC2_155      EGRAKLADAVAEHMSPPLPLIGAGELVSTAAKTLRESDAVMVVEDGKPVG
Mflv_2043|M.gilvum_PYR-GCK          EGRAKLADAVAQHMSPPLPLIGAGELVSAAAKTLRECDAVMVVEEGKPAG
Mvan_4674|M.vanbaalenii_PYR-1       EGRAKLADAVADHMGPPLPLIGVGELVSTAAKALRESDAVMVVEEGKPVG
MAB_1195|M.abscessus_ATCC_1997      EGRAQLADAVAQHMSPPLPLVGSGEPLSTAGSMLRDTDAVMVVDEGKPVG
                                    .*:*.*:***: **..** ::* ** : .*.. **: **:***:.** .*

MMAR_4390|M.marinum_M               VITRYDLLGFLSEG----ALRR
MUL_0203|M.ulcerans_Agy99           VITRYDLLGFLSEG----ALRR
MAV_1201|M.avium_104                VITRYDLLGFLSEGPRGSGGRR
Mb1106|M.bovis_AF2122/97            VITRYDLLGFLSEG----AGRR
Rv1077|M.tuberculosis_H37Rv         VITRYDLLGFLSEG----AGRR
MLBr_02396|M.leprae_Br4923          VITRYDLLGFLSEG----APLR
TH_1371|M.thermoresistible__bu      VLTRHDLLGFLSES----TAAH
MSMEG_5270|M.smegmatis_MC2_155      VLTRHDLLGFLSEG----GYRH
Mflv_2043|M.gilvum_PYR-GCK          VLTRHDLLGYLSDS----SPGH
Mvan_4674|M.vanbaalenii_PYR-1       VLTRHDLLGYLSEG----NARR
MAB_1195|M.abscessus_ATCC_1997      VITRHDLLGFVSSGR---GVRH
                                    *:**:****::*..       :