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MTEPLSVDADGVRSLGEIHNRVAAGLGSLAAASPGPAAVAGSHGTIAAAVDTALTGALGSRSGTLAGTRT AGDTISELLHQAALAYERGDHRGAEAIRTAADQMAHGPTQAGAAGAAPPAGGTPTGGGADALGQAAGQLG QLAQMGQQLGAPLAALAQLPQLLTQGLAQLAQSSSAETGSGVAEIPDVGDRTPGREPDEEPTADDDQPAA EDKEPEAPSDAGAAPGTPPGPGPAPVPQAPPRPAPTRPAVG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_4513 | - | - | 100% (251) | hypothetical protein Mvan_4513 |
| M. vanbaalenii PYR-1 | Mvan_0082 | - | 2e-10 | 29.22% (243) | hypothetical protein Mvan_0082 |
| M. vanbaalenii PYR-1 | Mvan_0085 | - | 2e-07 | 26.41% (231) | hypothetical protein Mvan_0085 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3908 | - | 1e-12 | 27.66% (282) | hypothetical protein Mb3908 |
| M. gilvum PYR-GCK | Mflv_2182 | - | 1e-61 | 54.92% (264) | hypothetical protein Mflv_2182 |
| M. tuberculosis H37Rv | Rv3878 | - | 1e-12 | 27.66% (282) | hypothetical protein Rv3878 |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_1945c | - | 2e-07 | 30.43% (230) | dihydrolipoamide succinyltransferase |
| M. marinum M | MMAR_1110 | - | 2e-09 | 28.04% (271) | hypothetical protein MMAR_1110 |
| M. avium 104 | MAV_2415 | - | 6e-08 | 30.18% (169) | hypothetical protein MAV_2415 |
| M. smegmatis MC2 155 | MSMEG_5101 | - | 2e-25 | 30.57% (265) | hypothetical protein MSMEG_5101 |
| M. thermoresistible (build 8) | TH_1469 | - | 2e-19 | 46.85% (111) | CONSERVED HYPOTHETICAL PROTEIN |
| M. ulcerans Agy99 | MUL_0868 | - | 2e-09 | 27.88% (269) | hypothetical protein MUL_0868 |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_4513|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_2182|M.gilvum_PYR-GCK --------------------------------------------------
Mb3908|M.bovis_AF2122/97 --------------------------------------------------
Rv3878|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_1110|M.marinum_M --------------------------------------------------
MUL_0868|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_5101|M.smegmatis_MC2_155 --------------------------------------------------
MAV_2415|M.avium_104 MAPLAVDPEAMYAAGSAVAAIGDSLAANLTILTAGVSAHTGVDRAGEVFG
TH_1469|M.thermoresistible__bu --------------------------------------------------
MAB_1945c|M.abscessus_ATCC_199 --------------------------------------------------
Mvan_4513|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_2182|M.gilvum_PYR-GCK --------------------------------------------------
Mb3908|M.bovis_AF2122/97 --------------------------------------------------
Rv3878|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_1110|M.marinum_M --------------------------------------------------
MUL_0868|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_5101|M.smegmatis_MC2_155 --------------------------------------------------
MAV_2415|M.avium_104 LGYQDSAESMLKAAAGVVNACRKCGALIQQGASNYSAAEAASTLGGGSGA
TH_1469|M.thermoresistible__bu --------------------------------------------------
MAB_1945c|M.abscessus_ATCC_199 --------------------------------------------------
Mvan_4513|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_2182|M.gilvum_PYR-GCK --------------------------------------------------
Mb3908|M.bovis_AF2122/97 --------------------------------------------------
Rv3878|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_1110|M.marinum_M --------------------------------------------------
MUL_0868|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_5101|M.smegmatis_MC2_155 --------------------------------------------------
MAV_2415|M.avium_104 LPAPSAPADLAAPGPPGTWGKGEPPPLLWAVIQALVSEVWPDGDEAGLHA
TH_1469|M.thermoresistible__bu --------------------------------------------------
MAB_1945c|M.abscessus_ATCC_199 ---------------------MAFSVQMPALGESVTEGTVTRWLKQEGDT
Mvan_4513|M.vanbaalenii_PYR-1 --------------------------MTEPLSVDADGVRSLGEIHNRVAA
Mflv_2182|M.gilvum_PYR-GCK --------------------------MSQPFSVDPDGVRALGEIHSGVAA
Mb3908|M.bovis_AF2122/97 --------------------------MAEPLAVDPTGLSAAAAKLAGLVF
Rv3878|M.tuberculosis_H37Rv --------------------------MAEPLAVDPTGLSAAAAKLAGLVF
MMAR_1110|M.marinum_M --------------------MTNGLAVAQRLDEGRPAVDHTRRYLRACQQ
MUL_0868|M.ulcerans_Agy99 --------------------MTNGLAVAQRLDEGRPAVDHTRRYLRACQQ
MSMEG_5101|M.smegmatis_MC2_155 ---------------------------MNQVIANTGAMNSWQQQLGEVSS
MAV_2415|M.avium_104 AASRWHGFAAAMNGVQGTLNASKALFDSQQIPEGEKIDHALAEIGAAAAA
TH_1469|M.thermoresistible__bu --------------------------LSGNVFVQPEGLQTFSQTHSGIAG
MAB_1945c|M.abscessus_ATCC_199 VEVDEPLLEVSTDKVDTEIPAPTSGVLTKIVAREDDTVEIGGELGVISEA
.
Mvan_4513|M.vanbaalenii_PYR-1 GLGSLAAASPGPAAVAGSHG------------------------------
Mflv_2182|M.gilvum_PYR-GCK DLGSMSASAAGSAPVAATHG------------------------------
Mb3908|M.bovis_AF2122/97 PQPPAPIAVSGTDSVVAAIN------------------------------
Rv3878|M.tuberculosis_H37Rv PQPPAPIAVSGTDSVVAAIN------------------------------
MMAR_1110|M.marinum_M LGYQDPVLAKGFDPIGDRYDSEDGLDLYLLD-------------------
MUL_0868|M.ulcerans_Agy99 LGYQDPFLAKGFDPIGDRYDSEDGLDLYLLD-------------------
MSMEG_5101|M.smegmatis_MC2_155 GVGNLLNGTPGVSDVMNTHG------------------------------
MAV_2415|M.avium_104 IGQQCDALARTVDEFADRVGHAQQAIRDLLHRIEALGDIGHDIMLIIDGD
TH_1469|M.thermoresistible__bu ALPQSSAEATP-GPVETSHG------------------------------
MAB_1945c|M.abscessus_ATCC_199 GEAAPAAPAPAPAPAAAPAPEPTPAPAPEAT-------------------
Mvan_4513|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_2182|M.gilvum_PYR-GCK --------------------------------------------------
Mb3908|M.bovis_AF2122/97 --------------------------------------------------
Rv3878|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_1110|M.marinum_M --------------------------------------------------
MUL_0868|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_5101|M.smegmatis_MC2_155 --------------------------------------------------
MAV_2415|M.avium_104 AWDEIQKIARDVNAVLQHLGQEARAFEQEIRLLMQAADREIVTCQKYARR
TH_1469|M.thermoresistible__bu --------------------------------------------------
MAB_1945c|M.abscessus_ATCC_199 --------------------------------------------------
Mvan_4513|M.vanbaalenii_PYR-1 --------TIAAAVDTALTGALGSRSG-----------------------
Mflv_2182|M.gilvum_PYR-GCK --------TIAAAVDTALGGALGSRAR-----------------------
Mb3908|M.bovis_AF2122/97 --------KTMPSIESLVSDGL----------------------------
Rv3878|M.tuberculosis_H37Rv --------ETMPSIESLVSDGL----------------------------
MMAR_1110|M.marinum_M -----GDCARLRAAGATIAEALGMQRGQVG--------------------
MUL_0868|M.ulcerans_Agy99 -----GDCARLRAAGATIAEALGMQRGQVG--------------------
MSMEG_5101|M.smegmatis_MC2_155 --------TIGFPMQSAFDAAHAARGG-----------------------
MAV_2415|M.avium_104 GLITFLGEDVGNPVATALDFGINVQEGVVKGAVGMGLGLVDLSPHWIALD
TH_1469|M.thermoresistible__bu --------PIAAAANAALRNALSSRGG-----------------------
MAB_1945c|M.abscessus_ATCC_199 --------ATAAPEPAAEPPAAAAPAGSGTSVKMPELG------------
. : .
Mvan_4513|M.vanbaalenii_PYR-1 --------------------------TLAGTRTAGDTISELLHQAALAYE
Mflv_2182|M.gilvum_PYR-GCK --------------------------SLTRTRSVSETISELLHQATLAYE
Mb3908|M.bovis_AF2122/97 ----------------------------PGVKAALTRTASNMNAAADVYA
Rv3878|M.tuberculosis_H37Rv ----------------------------PGVKAALTRTASNMNAAADVYA
MMAR_1110|M.marinum_M --------------------ALAMAWTGPGADAAVNFLQRHVEAGQRIVA
MUL_0868|M.ulcerans_Agy99 --------------------ALAMAWTGPGADAAVNFLQRHVEAGQRIVA
MSMEG_5101|M.smegmatis_MC2_155 --------------------------AMGATQAASSKISDLLRQAAQAYE
MAV_2415|M.avium_104 PEGAGATWGGLVKNAWKESFVNAAVNPQEFAQARLQELKGLVHADDWTRD
TH_1469|M.thermoresistible__bu --------------------------TVQATTTSAATISELLHRAARAYQ
MAB_1945c|M.abscessus_ATCC_199 -----------------------ESVTEGTVTRWLKKVGDEVGVDEPLVE
. :
Mvan_4513|M.vanbaalenii_PYR-1 RGDHRGAEAIR-------------------TAADQMAHGPTQAGAAGAAP
Mflv_2182|M.gilvum_PYR-GCK RGDEQGGDAIR-------------------AAADAMAQDEGSQTTAGGAT
Mb3908|M.bovis_AF2122/97 KTDQSLG-----------------------TSLSQYAFGSSGEGLAGVAS
Rv3878|M.tuberculosis_H37Rv KTDQSLG-----------------------TSLSQYAFGSSGEGLAGVAS
MMAR_1110|M.marinum_M EVRAAALGCESLREDLWRL---VDTKVESVIAIDDRTLARRPAWLAACAE
MUL_0868|M.ulcerans_Agy99 EVRAAALGCESLREDLWRL---VDMKVESVIAIDDRTLARRPAWLAACAE
MSMEG_5101|M.smegmatis_MC2_155 RGDVTAADDLK-------------------KRAEQLEGAGASSAAGGSAA
MAV_2415|M.avium_104 RPGLGAGEVAFDAATLIAPGLGEAGAAADGASAAARGAEAEADAAGAAGR
TH_1469|M.thermoresistible__bu EGDLRSAEELR-------------------AAANAIADGTGAGGXXXAHE
MAB_1945c|M.abscessus_ATCC_199 VSTDKVDTEIPSPVAGVLLSISANEDDTVAVGGELAVVGAADAAPAAPAA
Mvan_4513|M.vanbaalenii_PYR-1 PAGGTPTGGGADALG---------------------QAAGQLGQLAQMG-
Mflv_2182|M.gilvum_PYR-GCK -TGGTPAG--ADPFA---------------------QAVGQLGQLGQLFT
Mb3908|M.bovis_AF2122/97 VGG---QPSQATQLLSTPVS----------------QVTTQLGETAAELA
Rv3878|M.tuberculosis_H37Rv VGG---QPSQATQLLSTPVS----------------QVTTQLGETAAELA
MMAR_1110|M.marinum_M VGAGAAPGSAAAELVRHQINPYLDNDIRDDWLGAMRAATAGIGAAYTTLA
MUL_0868|M.ulcerans_Agy99 VGGGAAPGSAAAELVRHQINPYLDNDIRDDWLGAMRAATAGIGAAYTTLA
MSMEG_5101|M.smegmatis_MC2_155 GSAASAASSGGQAAS---------------------QMMSQFGQMAGQMA
MAV_2415|M.avium_104 VGGIAGARGALTDIAKSTADLPKNLEGVTKDLPEIKPPTGGAPVGLGPGG
TH_1469|M.thermoresistible__bu RVRKAAKAADRAAGDDE-------------------RDEALHRIRKGAKR
MAB_1945c|M.abscessus_ATCC_199 PAAPAPEPAAAPAAAAAPPAPPAPAPAP----AAPAPASTAPAANGAAGD
Mvan_4513|M.vanbaalenii_PYR-1 QQLGAPLAALAQLP----------QLLTQGLAQLAQSSSAETG-------
Mflv_2182|M.gilvum_PYR-GCK APLAALAQPLQQLP----------QQLMQGLQQSARSSPDATEP------
Mb3908|M.bovis_AF2122/97 PRVVATVPQLVQLAPHAVQMSQNASPIAQTISQTAQQAAQSAQG------
Rv3878|M.tuberculosis_H37Rv PRVVATVPQLVQLAPHAVQMSQNASPIAQTISQTAQQAAQSAQG------
MMAR_1110|M.marinum_M DRLTSSVP-VSFDHPDDLGSGPQSPPVPSALAAIAPAAATSAPAPDPEPA
MUL_0868|M.ulcerans_Agy99 DRLTSSVP-VSFDHPDDLGSGRQSPPVPSALAAIAPAAATSAPAPDPEPA
MSMEG_5101|M.smegmatis_MC2_155 QSLTQPIQGMAQSLG------QMPQQIFQGVQGIVQSATEGAGGG-----
MAV_2415|M.avium_104 KPIEAPVESAPRPPDGTPGAQRGSPPVATSPASPGPAGDSGAGPHGPSS-
TH_1469|M.thermoresistible__bu LRYLAAAAGAAEVADR-------AEAVQTLLGEHQDSVVSRAH-------
MAB_1945c|M.abscessus_ATCC_199 NPYVTPLVRKLAAENNVDLSALSGSGVGGRIRKQDVLAAAEAAKAPAAAP
: :
Mvan_4513|M.vanbaalenii_PYR-1 --------SGVAEIPDVG--------------------------------
Mflv_2182|M.gilvum_PYR-GCK ---DVSAPAGVVTDPDVG--------------------------------
Mb3908|M.bovis_AF2122/97 --GSGPMPAQLASAEKP---------------------------------
Rv3878|M.tuberculosis_H37Rv --GSGPMPAQLASAEKP---------------------------------
MMAR_1110|M.marinum_M FAASPAVPAGIAPAPGAGLELPTDAGDFGALGDFGGPGGLGAAGTGGLGG
MUL_0868|M.ulcerans_Agy99 FAASPAVPAGIAPAPGAGLELPTDAGDFGALGDFGGPGGLGAAGTGGLGG
MSMEG_5101|M.smegmatis_MC2_155 -LEAATAAAGGAKAENAIKTG-----------------------------
MAV_2415|M.avium_104 -SPAPAAPPGGPVGPHDPAPAPAPAASPGGPGGSGGVHDPAPAPAPAPAA
TH_1469|M.thermoresistible__bu --------------------------------------------------
MAB_1945c|M.abscessus_ATCC_199 APAAPAASAPAAVAPSLAHLRG----------------------------
Mvan_4513|M.vanbaalenii_PYR-1 ------------------DRTPGREPDEEPTADD--------------DQ
Mflv_2182|M.gilvum_PYR-GCK ------------------TDVAPDEPDDDPDDTA--------------AE
Mb3908|M.bovis_AF2122/97 -------------------ATEQAEPVHEVTNDDQGDQ---------GDV
Rv3878|M.tuberculosis_H37Rv -------------------ATEQAEPVHEVTNDDQGDQ---------GDV
MMAR_1110|M.marinum_M LAGLAGRIVDALAELLGTAAVPIADPLGSVDPADGGDRSGADAVDDVGDE
MUL_0868|M.ulcerans_Agy99 LAGLAGRIVDALAELLGTAAVPIADPLGSVDPADGGDRSGADAVDDVGDE
MSMEG_5101|M.smegmatis_MC2_155 ----------------GAEGAAGGEGERAPVDTADKGTAD--------KD
MAV_2415|M.avium_104 SGGPGDPASVPSGGPHEPASVPAEEPREPVSVPAGGVHDPVAEPTGGPHE
TH_1469|M.thermoresistible__bu -------------------LIAQADAAHAAGADTFTYG-----------L
MAB_1945c|M.abscessus_ATCC_199 ----------TTQKANRIRQITAKKTRESLQETAQLTQTHEVDVTKIAAL
.
Mvan_4513|M.vanbaalenii_PYR-1 PAAEDKE------PEAPSDAGAA-----------------PGTPPG----
Mflv_2182|M.gilvum_PYR-GCK RDSRDDA------EASDDDAAAD-----------------PGSPRE----
Mb3908|M.bovis_AF2122/97 QPAEVVA------AARDEGAGAS-----------------PGQQPGGGVP
Rv3878|M.tuberculosis_H37Rv QPAEVVA------AARDEGAGAS-----------------PGQQPGGGVP
MMAR_1110|M.marinum_M NPSEPRK------PDAATETGASDEKSDNGEAPEAADGSPPGAPAGDGAE
MUL_0868|M.ulcerans_Agy99 NPSESRK------PDAATETGASDEKSDDGEAPEAADGSPPGAPAGDGAE
MSMEG_5101|M.smegmatis_MC2_155 KTDERDK------TTDAVQVGAR---------------ADIGVPAE----
MAV_2415|M.avium_104 PASVPAAGSRLASVQAAAGDGLPSATPQLFDHTPSQVPVPAGGSSGEAAS
TH_1469|M.thermoresistible__bu LYQQEVA------LAQRCRAQLD---------------------------
MAB_1945c|M.abscessus_ATCC_199 RARAKAAFAE---REGVNLTFLPFFAKAAVEALKTHPNVNASYNEESKEI
Mvan_4513|M.vanbaalenii_PYR-1 --------------------------PGPAPVPQAPPRPAPTRPAVG---
Mflv_2182|M.gilvum_PYR-GCK --------------------------PAPA---RAEPRPAPIRPAPG---
Mb3908|M.bovis_AF2122/97 AQAMDTGAGAR-------------PAASPLAAPVDPSTPAPSTTTTL---
Rv3878|M.tuberculosis_H37Rv AQAMDTGAGAR-------------PAASPLAAPVDPSTPAPSTTTTL---
MMAR_1110|M.marinum_M RSAMPIGEQARTPVPEGAATPVAQPPRVPEAPPHDGSAPAGEASSPCEIA
MUL_0868|M.ulcerans_Agy99 RSAMPIGEQARTPVPEGAATPVAQPPRVPEAPPHDGSAPAGEASSPCEIA
MSMEG_5101|M.smegmatis_MC2_155 --------------------------EQPGVGAVSTQIPTISPRPQ----
MAV_2415|M.avium_104 VGAHSPSSASSAAPHFESPGGRPSEVPAPNGGAHGPGESGPAGGHPPGEP
TH_1469|M.thermoresistible__bu ----------------------------PALKKLRKAVRRYRKRG-----
MAB_1945c|M.abscessus_ATCC_199 TYFDAEHLGIAVDTDQGLLSPVIHNAGDLSLAGLARAIADIAARARSGNL
Mvan_4513|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_2182|M.gilvum_PYR-GCK --------------------------------------------------
Mb3908|M.bovis_AF2122/97 --------------------------------------------------
Rv3878|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_1110|M.marinum_M ADELPKAGP-----------------------------------------
MUL_0868|M.ulcerans_Agy99 ADELPKAGP-----------------------------------------
MSMEG_5101|M.smegmatis_MC2_155 --------------------------------------------------
MAV_2415|M.avium_104 PHGGKPSGDGGPPDEDSHRDGTPGNGDDGAAGEIDDGPAGVDGQSTPAKV
TH_1469|M.thermoresistible__bu --------------------------------------------------
MAB_1945c|M.abscessus_ATCC_199 KPDELAGGTFTITNIGSQGALFDTPILVPPQAAMLGTGAIVKRPRVIRDD
Mvan_4513|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_2182|M.gilvum_PYR-GCK --------------------------------------------------
Mb3908|M.bovis_AF2122/97 --------------------------------------------------
Rv3878|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_1110|M.marinum_M --------------------------------------------------
MUL_0868|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_5101|M.smegmatis_MC2_155 --------------------------------------------------
MAV_2415|M.avium_104 AGVDYPLPPSDALRVLEHPGAELQRLADGGVPSSILEGYEPLAGRSVDDF
TH_1469|M.thermoresistible__bu --------------------------------------------------
MAB_1945c|M.abscessus_ATCC_199 AGNESIGIRSVCYLPLTYDHRLIDGADAGRFLTTIKHRLEEGAFEADLGL
Mvan_4513|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_2182|M.gilvum_PYR-GCK --------------------------------------------------
Mb3908|M.bovis_AF2122/97 --------------------------------------------------
Rv3878|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_1110|M.marinum_M --------------------------------------------------
MUL_0868|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_5101|M.smegmatis_MC2_155 --------------------------------------------------
MAV_2415|M.avium_104 NREFTIETSNGERGWDWEAQAPENGFAGNPIESNHIPAGLHFDRIGPNGG
TH_1469|M.thermoresistible__bu --------------------------------------------------
MAB_1945c|M.abscessus_ATCC_199 --------------------------------------------------
Mvan_4513|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_2182|M.gilvum_PYR-GCK --------------------------------------------------
Mb3908|M.bovis_AF2122/97 --------------------------------------------------
Rv3878|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_1110|M.marinum_M --------------------------------------------------
MUL_0868|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_5101|M.smegmatis_MC2_155 --------------------------------------------------
MAV_2415|M.avium_104 GFLSPEGVPLAERATPPGLAAQYHVFEGTGREIPAGKDWVVQHGPAKEAF
TH_1469|M.thermoresistible__bu --------------------------------------------------
MAB_1945c|M.abscessus_ATCC_199 --------------------------------------------------
Mvan_4513|M.vanbaalenii_PYR-1 ------------------------------------------------
Mflv_2182|M.gilvum_PYR-GCK ------------------------------------------------
Mb3908|M.bovis_AF2122/97 ------------------------------------------------
Rv3878|M.tuberculosis_H37Rv ------------------------------------------------
MMAR_1110|M.marinum_M ------------------------------------------------
MUL_0868|M.ulcerans_Agy99 ------------------------------------------------
MSMEG_5101|M.smegmatis_MC2_155 ------------------------------------------------
MAV_2415|M.avium_104 GQPGGGDQWIVLDRATNRPVPVDELIRRRLLREITPPNDKLAIGYRGS
TH_1469|M.thermoresistible__bu ------------------------------------------------
MAB_1945c|M.abscessus_ATCC_199 ------------------------------------------------