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MITRRLATTGALVAVMAAATSGCGWRGANSISLPGTEGGGSGSYTIQAQLPDVGNIQQNSRVRLGDVNVG TVTKIERQGWHAVLTMKLNGDVALPANTTAAIGQTSLLGSLHVELAAPKDAAPEGRLHNGSVIPLSSGRA YPTTEQTLATLSLILNGGGIGQMQDITRSLSTAFAGREDDLRSLIEQVDIFIGNVKDQTHDIIAATDSLN RLVAQIAAQRPVLEKALKTIPRALAVLNDQRDNLVYALDQLGKFGALTADTVNQTRENLVKELNDVAPVL ESLADAGPAMVRSLSFLTTFPFVKENIGNFFRGDYVNLTGVFDLTLSRLDSGFFTGTRWEGDLTELEMQW GRTLGQMPSPYTVANPLTVPYRADQGR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_0926 | - | - | 100% (377) | virulence factor Mce family protein |
| M. vanbaalenii PYR-1 | Mvan_3978 | - | e-150 | 68.90% (373) | virulence factor Mce family protein |
| M. vanbaalenii PYR-1 | Mvan_0517 | - | e-145 | 65.61% (378) | virulence factor Mce family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0179 | lprK | 1e-71 | 39.46% (370) | MCE-family lipoprotein LprK |
| M. gilvum PYR-GCK | Mflv_2105 | - | 1e-144 | 66.23% (385) | virulence factor Mce family protein |
| M. tuberculosis H37Rv | Rv1970 | lprM | 1e-135 | 64.08% (373) | MCE-family lipoprotein LprM |
| M. leprae Br4923 | MLBr_02593 | lprK | 5e-69 | 38.95% (362) | putative lipoprotein |
| M. abscessus ATCC 19977 | MAB_4149c | - | 2e-63 | 38.99% (336) | MCE-family protein LprN |
| M. marinum M | MMAR_4055 | lprM_1 | 1e-150 | 70.14% (365) | MCE family lipoprotein LprM |
| M. avium 104 | MAV_2536 | - | 1e-139 | 63.16% (380) | virulence factor Mce family protein |
| M. smegmatis MC2 155 | MSMEG_0350 | - | 1e-145 | 65.07% (375) | virulence factor Mce family protein |
| M. thermoresistible (build 8) | TH_4336 | - | 1e-146 | 66.94% (366) | PUTATIVE MCE-family lipoprotein LprM_1 |
| M. ulcerans Agy99 | MUL_3922 | lprM_1 | 1e-150 | 69.86% (365) | MCE family lipoprotein LprM |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_0350|M.smegmatis_MC2_155 ---------MTHMRRVVACAATVAALMIGVTGCSNWRGLNSVSLPGTEGG
TH_4336|M.thermoresistible__bu ------------MRSATVSALALVVLSAALLAGCGWQGLNSVPLPGTQGR
Mvan_0926|M.vanbaalenii_PYR-1 -----------MITRRLATTGALVAVMAAATSGCGWRGANSISLPGTEGG
MMAR_4055|M.marinum_M -------MMWARWTTRIRIAAGIAALAVAVSGCSGWRGLNSLPLPGVQGG
MUL_3922|M.ulcerans_Agy99 --------MRAGWTTRIRIAAGIAALAVAVSGCSGWRGLNSLPLPGVQGG
Mflv_2105|M.gilvum_PYR-GCK --------MTAVRASATMALAVTMAAAVTVSGC-GWRGLNSVPLPGTQGG
Rv1970|M.tuberculosis_H37Rv -----------------MRIGLTLVMIAAVVASCGWRGLNSLPLPGTQGN
MAV_2536|M.avium_104 --------MSQSPLRRRVMAALLAAVALATLSGCGFRGLNSFNLPGTKGG
MAB_4149c|M.abscessus_ATCC_199 ------------MSRNVLRAAVMGVGVAVVVSGCQFNGLNSLNLPGTAGH
Mb0179|M.bovis_AF2122/97 ---MMSVLARMRVMRHRAWQGLVLLVLALLLSSCGWRGISNVAIPGGPGT
MLBr_02593|M.leprae_Br4923 MRRAMSVVHTSRVR-HQTWRGLVMLVAALLLSSCGWRGISNVSIPGGPGS
. :.* ... :** *
MSMEG_0350|M.smegmatis_MC2_155 GPGAFDIQVQMPDITNLQPNSRVRVADVTVGTVTKVERQ-----GWHALL
TH_4336|M.thermoresistible__bu GADAFTIQAQLPDVNNLQQNSRVRVGDVDVGTVAKIERQ-----GWHALV
Mvan_0926|M.vanbaalenii_PYR-1 GSGSYTIQAQLPDVGNIQQNSRVRLGDVNVGTVTKIERQ-----GWHAVL
MMAR_4055|M.marinum_M GPGSFTIQAQMPDVDNIEPNSRVRVGDVNVGTVTKIERQ-----GWHALV
MUL_3922|M.ulcerans_Agy99 GPGSFTIQAQMPDVDNIEPNSRVRVGDVNVGTVTKIERQ-----GWHALV
Mflv_2105|M.gilvum_PYR-GCK GPGSFTIQAQMPDVDNVEQNSRVRVGDVNVGTVSKIERQ-----GWNALV
Rv1970|M.tuberculosis_H37Rv GPGSFAVQAQLPDVNNIQPNSRVRVADVTVGHVTKIERQ-----GWHALV
MAV_2536|M.avium_104 GPGAYTIRAQMPDVQNLQRNSRVRVNDVTVGNVIDIELQ-----GWNALV
MAB_4149c|M.abscessus_ATCC_199 GSRSYTVTVELPDVTTLPQNSPVMVDDVTVGSVSGIDAFQKPDGSWYAGV
Mb0179|M.bovis_AF2122/97 GPGSYTIYVQMPDTLAINGNSRVMVADVWVGSIRAIKLK-----NWVATL
MLBr_02593|M.leprae_Br4923 GKGAYTIYVQVPDTLAINGNSKVMVADVTVGSIRAINLK-----NWVATL
* :: : .::** : ** * : ** ** : :. .* * :
MSMEG_0350|M.smegmatis_MC2_155 TLRLNGDVNLPANCTATIGQTSLLGSLHVELAPPAAAPPQGRLHQGSLIP
TH_4336|M.thermoresistible__bu TIRLNGDVDLPANSTVTVGQTSLLGSLHVELAPPVDEPPQGSLRDGAFIP
Mvan_0926|M.vanbaalenii_PYR-1 TMKLNGDVALPANTTAAIGQTSLLGSLHVELAAPKDAAPEGRLHNGSVIP
MMAR_4055|M.marinum_M TMKLNGNVELPANATATLGQTSLLGSLHIELAPPTDVPPEGNLREGSLIP
MUL_3922|M.ulcerans_Agy99 TMKLNGNVELPANATATLGQTSLLGSLHIELAPPTDVPPEGNLREGSLIP
Mflv_2105|M.gilvum_PYR-GCK TMTLNGDVNLPANATAKVGQTSLLGSQHIELAAPADEAPQGRLEEGTLIP
Rv1970|M.tuberculosis_H37Rv TMRLDGDVDLPANATAKIGTTSLLGSYHIELAPPKGEARQGKLRDGSLIA
MAV_2536|M.avium_104 TMTIDGDVDLPANATATLGQTSLLGSVHVELAPPAGVAPQGKLKNGSLIP
MAB_4149c|M.abscessus_ATCC_199 KVSLEPEVHLPANAVAKVAQTSLLGSQHIELAAPVGEPAVGKLTGGATIP
Mb0179|M.bovis_AF2122/97 TLSLKKDVTLPKNATAKIGQTSLLGSQHVELAAPPD-PSPVPLKDGDTIP
MLBr_02593|M.leprae_Br4923 TLGLNKDVQLPKNTTAKIGQTSLLGSQHVELAAPAN-PSLELLKNGDTIP
.: :. :* ** * .. :. ****** *:***.* . * * *.
MSMEG_0350|M.smegmatis_MC2_155 LADSTTHPTTEQTLAAVSMLLNGGGLGQMQDITKALSTALRGREADLRNL
TH_4336|M.thermoresistible__bu LDSGGAYPSTEQTLAAVSLLLNGGGLGQVQDITRALSTAFGGREDELRSL
Mvan_0926|M.vanbaalenii_PYR-1 LSSGRAYPTTEQTLATLSLILNGGGIGQMQDITRSLSTAFAGREDDLRSL
MMAR_4055|M.marinum_M LSSSKAYPSTEQALAATAMLLNGGGIGDIYDITEALSTAFTGRENDLRSL
MUL_3922|M.ulcerans_Agy99 LSSSKAYPSTEQALAATAMLLNGGGIGDIYDITEALSTAFTGRENDLRSL
Mflv_2105|M.gilvum_PYR-GCK LASAGAYPSTEQALAAVALLLNGGGLGNIQDITDALSTAFSGRENDLRSL
Rv1970|M.tuberculosis_H37Rv LSHGSAYPSTEQTLAALSLVLNGGGLGQVQDITEALSTAFAGREHDLRGL
MAV_2536|M.avium_104 LSSAGAYPSTERTLAAVSLLLNGGGLGQVQDITKTLSTAFSGREQDLRNL
MAB_4149c|M.abscessus_ATCC_199 LSRTGKYPSTEEVLSALSVVVNKGNLGALQDITDETYNLFKGRTGNLTQV
Mb0179|M.bovis_AF2122/97 LKRSSAYPTTEQTLASIATLLRGGGLVNLEGIQQEINAIVTGRADQIRAF
MLBr_02593|M.leprae_Br4923 LKNSSVFPTTEQTLASLSLILRGGGIPNLETLTNEVFNIFHGRADQIHAF
* .*:**..*:: : ::. *.: : : . ** :: .
MSMEG_0350|M.smegmatis_MC2_155 IGQLETFVAKTNDQTGDIIEATEKLNRLTGKFAAQQPVVDKAVRTIPDAL
TH_4336|M.thermoresistible__bu MSRLETFTSRINDQTDDVIAATEALNRLVAQFSSQRPVVDKALDTIPAAL
Mvan_0926|M.vanbaalenii_PYR-1 IEQVDIFIGNVKDQTHDIIAATDSLNRLVAQIAAQRPVLEKALKTIPRAL
MMAR_4055|M.marinum_M IEQLDEAIGHLDDQKGDIIAAAESLNNLMAQLAAQRPVLDKALRTIPDAL
MUL_3922|M.ulcerans_Agy99 IEQLDEAIGHLDDQKGDIIAAAESLNNLMAQLAAQRPVLDKALRTIPDAL
Mflv_2105|M.gilvum_PYR-GCK IEQLDIAVGHLDDQTGDIIATSESLNNVVGQIAEQKPVVDKALRTIPDAL
Rv1970|M.tuberculosis_H37Rv IGQLDTFTAYLNNQSGDIIAATDSLNRLVGKFADQQPVFDRALATIPDAL
MAV_2536|M.avium_104 LNQLDTFVGYLNDQKSDIIAATDHLNNLVGQFADQKPIIDKALKTIPQAL
MAB_4149c|M.abscessus_ATCC_199 LPKLATLISSLNSQRDDIISAIEGIDKFSRVLAEHKESLGRAIDSIEPAL
Mb0179|M.bovis_AF2122/97 LGKLDTFTDELNQQRDDITRAIDSTNRLLAYVGGRSEVLNRVLTDLPPLI
MLBr_02593|M.leprae_Br4923 LTKLDTFASQLNQQRDDITHAIDSTNRLLTYVGGRSDVLDQILTDIPPLI
: :: ..* *: : : :.. .. : . : : : :
MSMEG_0350|M.smegmatis_MC2_155 EVLKDQRDNLTAALDQLGRFSALAADSTRQTKDSLVREFRNIGPVLESLA
TH_4336|M.thermoresistible__bu AVLNSEREELIEAVEELGTFNELAADTIDQTRDAVVEELRDMGPVLESLA
Mvan_0926|M.vanbaalenii_PYR-1 AVLNDQRDNLVYALDQLGKFGALTADTVNQTRENLVKELNDVAPVLESLA
MMAR_4055|M.marinum_M AVLKNERENLADALTQLGRFSALAADSVNQTKDALVQELKDLGPTLESLA
MUL_3922|M.ulcerans_Agy99 TVLKNERENLADALTQLGRFSALAADSVNQTKDALVQELKDLGPTLESLA
Mflv_2105|M.gilvum_PYR-GCK AVLRDQRDTLSEALVQLGRFSALAADSVTKTREALIQELKDLGPVLQSLA
Rv1970|M.tuberculosis_H37Rv AVLADERDTLVEAAEQLSKFSALTVDSVNKTTANLVTELRQLGPVLESLA
MAV_2536|M.avium_104 TVLKDERENLANALGEVGQLSALAADSVNKTKENLIKELKDLGPVLQSLA
MAB_4149c|M.abscessus_ATCC_199 KVLNENRANIIEAFRSVGNLAKITDRVLRTTKDDIVADLKGLYPVVRALA
Mb0179|M.bovis_AF2122/97 KHFADKQELLINASDAVGRLSQSADQYLSAARGDLHQDLQALQCPLKELR
MLBr_02593|M.leprae_Br4923 KHFADTKNLLINAVGSVGQLSQAVDQYLSEARGPLHTDLQALACPLRELG
: . : : * :. : . : : ::. : :. *
MSMEG_0350|M.smegmatis_MC2_155 NAGPNMTRALSILTTYPFPNETLEKWLRGDYGNMTAIVDLTLSRIDAGFF
TH_4336|M.thermoresistible__bu NAGPALTRSLSLFTTFPFPKETLTKWMRGDYANITVVADLTLSRMDSALF
Mvan_0926|M.vanbaalenii_PYR-1 DAGPAMVRSLSFLTTFPFVKENIGNFFRGDYVNLTGVFDLTLSRLDSGFF
MMAR_4055|M.marinum_M NAGPALTRALSFLPTYPFPKETLTNWMRGDYANLTLIIDMTLSRIDAGFF
MUL_3922|M.ulcerans_Agy99 NAGPALTRALSFLPTYPFPKETLTNWMRGDYANLTLIIDMTLSRIDAGFF
Mflv_2105|M.gilvum_PYR-GCK DAGPALTRALSFLPTFPFPKETLTNWMRGDYANLTLVVDLTLSRIDQGFF
Rv1970|M.tuberculosis_H37Rv NSGPALTRSLSLLATFPFPNETFQNFQRGEYANLTAIVDLTLSRIDQGLL
MAV_2536|M.avium_104 DAGPALTRSLGFLGTFPFPAETLSKWIRGDYANLTAVIDLTLSRLDASFL
MAB_4149c|M.abscessus_ATCC_199 ENRDVLIDSLDLLPTFPFSTKYLRNAVRGDYLNVFVTFDLTARRLGETLF
Mb0179|M.bovis_AF2122/97 RAAPYLVGALKLILTQPFDVDTVPQLVRGDYMNLSLTLDLTYSAIDNAFL
MLBr_02593|M.leprae_Br4923 RGAPYFIGAMKLILTQPYDVDTVPKIMRGDYQNVSLTLDVTYSAMDNAVL
: :: :: * *: . . : **:* *: *:* :. .:
MSMEG_0350|M.smegmatis_MC2_155 TGTRWEGDLTELEMQWGR-TIGQLPSPY------TAVNPLVAPYRWDQGR
TH_4336|M.thermoresistible__bu TGTRWEGDLTELEMQWGR-TIGQLPSPY------TAANPLLAPYRWNQGP
Mvan_0926|M.vanbaalenii_PYR-1 TGTRWEGDLTELEMQWGR-TLGQMPSPY------TVANPLTVPYRADQGR
MMAR_4055|M.marinum_M TGTRWEGDLTELELQWGR-TIGQMPSPY------TVGNPLIVPYRWDQGP
MUL_3922|M.ulcerans_Agy99 TGTRWEGDLTELELQWGR-TIGQMPSPY------TVGNPLIVPYRWDQGP
Mflv_2105|M.gilvum_PYR-GCK TGTRFECNLTWLELQWGR-TIGQTPSPCNHNVPPPGSNPLVAPYRWDQGR
Rv1970|M.tuberculosis_H37Rv TGTRWECHLTQLELQWGR-TIGQFPSPCTAGYRGTPGNPLTIAYRWDQGP
MAV_2536|M.avium_104 TGTRFECNLTELELQWGR-TIGQLPSPCTGGGPYNPGNPLVVPYHFDQGR
MAB_4149c|M.abscessus_ATCC_199 TTSFFDPNMQHFNDVVNP-PEWLIGSMANLNGKETSPFDLPAPAAPQGGG
Mb0179|M.bovis_AF2122/97 TGTGFSGALRALEQSFGRDPETMIPDIR----YTPNPNDAPGGPLVERGN
MLBr_02593|M.leprae_Br4923 TGTGLSGALRALEQSFGRDPETMIPDVR----YTTNPNDAPGGPLVERAD
* : . : :: . . . : .
MSMEG_0350|M.smegmatis_MC2_155 ---
TH_4336|M.thermoresistible__bu ---
Mvan_0926|M.vanbaalenii_PYR-1 ---
MMAR_4055|M.marinum_M ---
MUL_3922|M.ulcerans_Agy99 ---
Mflv_2105|M.gilvum_PYR-GCK ---
Rv1970|M.tuberculosis_H37Rv ---
MAV_2536|M.avium_104 ---
MAB_4149c|M.abscessus_ATCC_199 R--
Mb0179|M.bovis_AF2122/97 RQC
MLBr_02593|M.leprae_Br4923 RRC