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SRTWRRRIMLSAATIAVVMGMSGCADWQGLNSLPMPGTEGGGPGSFVIQAQLPDVNNIQPNSRVRVGDVN VGTVTKVERQGWHALLTMRLNADVNLPENSTVTIGLTSILGSLHIELSPPAGAAPVGRLHDGSLIPLSSG GAFPSTEQTLAALSMVLNGGGLGQVQDITEAFSTAFDGREHDVRSLIGQLETFARNVNDQTGDIIAATES LNNLVGQFAAQRPVLDHALQTIPDALAVLDGERQNLIETADQFGKFSALTVDTVNKTKDNLVKELNDVGP VLESLADAGPSMTRALSLIPTFPFPNETIEKWQRGDYANLTAIADLTLSRIDAGMFTGTRWEGDLTELEL QWGRTIGQFPSPYTRANPLTVPYRWDQGP*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_3978 | - | - | 100% (380) | virulence factor Mce family protein |
| M. vanbaalenii PYR-1 | Mvan_0367 | - | e-160 | 72.19% (374) | virulence factor Mce family protein |
| M. vanbaalenii PYR-1 | Mvan_0926 | - | e-150 | 68.90% (373) | virulence factor Mce family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0179 | lprK | 2e-63 | 37.11% (353) | MCE-family lipoprotein LprK |
| M. gilvum PYR-GCK | Mflv_0648 | - | 1e-146 | 66.31% (377) | virulence factor Mce family protein |
| M. tuberculosis H37Rv | Rv1970 | lprM | 1e-152 | 70.71% (379) | MCE-family lipoprotein LprM |
| M. leprae Br4923 | MLBr_02593 | lprK | 5e-61 | 36.26% (353) | putative lipoprotein |
| M. abscessus ATCC 19977 | MAB_4149c | - | 3e-60 | 37.90% (343) | MCE-family protein LprN |
| M. marinum M | MMAR_4055 | lprM_1 | 1e-158 | 69.95% (376) | MCE family lipoprotein LprM |
| M. avium 104 | MAV_2536 | - | 1e-139 | 62.63% (380) | virulence factor Mce family protein |
| M. smegmatis MC2 155 | MSMEG_0350 | - | 1e-159 | 70.29% (377) | virulence factor Mce family protein |
| M. thermoresistible (build 8) | TH_4336 | - | 1e-151 | 68.01% (372) | PUTATIVE MCE-family lipoprotein LprM_1 |
| M. ulcerans Agy99 | MUL_3922 | lprM_1 | 1e-157 | 69.21% (380) | MCE family lipoprotein LprM |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_3978|M.vanbaalenii_PYR-1 --------MSRTWRRRIMLSAATIAVVMGMSGCADWQGLNSLPMPGTEGG
Rv1970|M.tuberculosis_H37Rv --------------MRIGLTLVMIAAVVASCG---WRGLNSLPLPGTQGN
MMAR_4055|M.marinum_M -------MMWARWTTRIRIAAGIAALAVAVSGCSGWRGLNSLPLPGVQGG
MUL_3922|M.ulcerans_Agy99 --------MRAGWTTRIRIAAGIAALAVAVSGCSGWRGLNSLPLPGVQGG
MSMEG_0350|M.smegmatis_MC2_155 ---------MTHMRRVVACAATVAALMIGVTGCSNWRGLNSVSLPGTEGG
Mflv_0648|M.gilvum_PYR-GCK ---------MTGKRFARAAAVIMIALTVAGLSGCGFRGLNSFRLPGTQGQ
TH_4336|M.thermoresistible__bu ------------MRSATVSALALVVLSAALLAGCGWQGLNSVPLPGTQGR
MAV_2536|M.avium_104 --------MSQSPLRRRVMAALLAAVALATLSGCGFRGLNSFNLPGTKGG
MAB_4149c|M.abscessus_ATCC_199 ------------MSRNVLRAAVMGVGVAVVVSGCQFNGLNSLNLPGTAGH
Mb0179|M.bovis_AF2122/97 ---MMSVLARMRVMRHRAWQGLVLLVLALLLSSCGWRGISNVAIPGGPGT
MLBr_02593|M.leprae_Br4923 MRRAMSVVHTSRVR-HQTWRGLVMLVAALLLSSCGWRGISNVSIPGGPGS
. :.*:... :** *
Mvan_3978|M.vanbaalenii_PYR-1 GPGSFVIQAQLPDVNNIQPNSRVRVGDVNVGTVTKVERQ-----GWHALL
Rv1970|M.tuberculosis_H37Rv GPGSFAVQAQLPDVNNIQPNSRVRVADVTVGHVTKIERQ-----GWHALV
MMAR_4055|M.marinum_M GPGSFTIQAQMPDVDNIEPNSRVRVGDVNVGTVTKIERQ-----GWHALV
MUL_3922|M.ulcerans_Agy99 GPGSFTIQAQMPDVDNIEPNSRVRVGDVNVGTVTKIERQ-----GWHALV
MSMEG_0350|M.smegmatis_MC2_155 GPGAFDIQVQMPDITNLQPNSRVRVADVTVGTVTKVERQ-----GWHALL
Mflv_0648|M.gilvum_PYR-GCK GQGSYTIQAEMPDVETLQPNSRVRVGDVNVGTVTKIERR-----GWHALL
TH_4336|M.thermoresistible__bu GADAFTIQAQLPDVNNLQQNSRVRVGDVDVGTVAKIERQ-----GWHALV
MAV_2536|M.avium_104 GPGAYTIRAQMPDVQNLQRNSRVRVNDVTVGNVIDIELQ-----GWNALV
MAB_4149c|M.abscessus_ATCC_199 GSRSYTVTVELPDVTTLPQNSPVMVDDVTVGSVSGIDAFQKPDGSWYAGV
Mb0179|M.bovis_AF2122/97 GPGSYTIYVQMPDTLAINGNSRVMVADVWVGSIRAIKLK-----NWVATL
MLBr_02593|M.leprae_Br4923 GKGAYTIYVQVPDTLAINGNSKVMVADVTVGSIRAINLK-----NWVATL
* :: : .::** : ** * * ** ** : :. .* * :
Mvan_3978|M.vanbaalenii_PYR-1 TMRLNADVNLPENSTVTIGLTSILGSLHIELSPPAGAAPVGRLHDGSLIP
Rv1970|M.tuberculosis_H37Rv TMRLDGDVDLPANATAKIGTTSLLGSYHIELAPPKGEARQGKLRDGSLIA
MMAR_4055|M.marinum_M TMKLNGNVELPANATATLGQTSLLGSLHIELAPPTDVPPEGNLREGSLIP
MUL_3922|M.ulcerans_Agy99 TMKLNGNVELPANATATLGQTSLLGSLHIELAPPTDVPPEGNLREGSLIP
MSMEG_0350|M.smegmatis_MC2_155 TLRLNGDVNLPANCTATIGQTSLLGSLHVELAPPAAAPPQGRLHQGSLIP
Mflv_0648|M.gilvum_PYR-GCK TLALNGDVDLPANSTVSLGQTSLLGSLHIELAPPTDVRPAGKLRAGSLIP
TH_4336|M.thermoresistible__bu TIRLNGDVDLPANSTVTVGQTSLLGSLHVELAPPVDEPPQGSLRDGAFIP
MAV_2536|M.avium_104 TMTIDGDVDLPANATATLGQTSLLGSVHVELAPPAGVAPQGKLKNGSLIP
MAB_4149c|M.abscessus_ATCC_199 KVSLEPEVHLPANAVAKVAQTSLLGSQHIELAAPVGEPAVGKLTGGATIP
Mb0179|M.bovis_AF2122/97 TLSLKKDVTLPKNATAKIGQTSLLGSQHVELAAPPD-PSPVPLKDGDTIP
MLBr_02593|M.leprae_Br4923 TLGLNKDVQLPKNTTAKIGQTSLLGSQHVELAAPAN-PSLELLKNGDTIP
.: :. :* ** * ...:. **:*** *:**:.* * * *.
Mvan_3978|M.vanbaalenii_PYR-1 LSSGGAFPSTEQTLAALSMVLNGGGLGQVQDITEAFSTAFDGREHDVRSL
Rv1970|M.tuberculosis_H37Rv LSHGSAYPSTEQTLAALSLVLNGGGLGQVQDITEALSTAFAGREHDLRGL
MMAR_4055|M.marinum_M LSSSKAYPSTEQALAATAMLLNGGGIGDIYDITEALSTAFTGRENDLRSL
MUL_3922|M.ulcerans_Agy99 LSSSKAYPSTEQALAATAMLLNGGGIGDIYDITEALSTAFTGRENDLRSL
MSMEG_0350|M.smegmatis_MC2_155 LADSTTHPTTEQTLAAVSMLLNGGGLGQMQDITKALSTALRGREADLRNL
Mflv_0648|M.gilvum_PYR-GCK LTSAGAYPSTEQTLASVSLLLNGGGVGQVQDITTALTSALGGREADFRSL
TH_4336|M.thermoresistible__bu LDSGGAYPSTEQTLAAVSLLLNGGGLGQVQDITRALSTAFGGREDELRSL
MAV_2536|M.avium_104 LSSAGAYPSTERTLAAVSLLLNGGGLGQVQDITKTLSTAFSGREQDLRNL
MAB_4149c|M.abscessus_ATCC_199 LSRTGKYPSTEEVLSALSVVVNKGNLGALQDITDETYNLFKGRTGNLTQV
Mb0179|M.bovis_AF2122/97 LKRSSAYPTTEQTLASIATLLRGGGLVNLEGIQQEINAIVTGRADQIRAF
MLBr_02593|M.leprae_Br4923 LKNSSVFPTTEQTLASLSLILRGGGIPNLETLTNEVFNIFHGRADQIHAF
* .*:**..*:: : ::. *.: : : . ** :. .
Mvan_3978|M.vanbaalenii_PYR-1 IGQLETFARNVNDQTGDIIAATESLNNLVGQFAAQRPVLDHALQTIPDAL
Rv1970|M.tuberculosis_H37Rv IGQLDTFTAYLNNQSGDIIAATDSLNRLVGKFADQQPVFDRALATIPDAL
MMAR_4055|M.marinum_M IEQLDEAIGHLDDQKGDIIAAAESLNNLMAQLAAQRPVLDKALRTIPDAL
MUL_3922|M.ulcerans_Agy99 IEQLDEAIGHLDDQKGDIIAAAESLNNLMAQLAAQRPVLDKALRTIPDAL
MSMEG_0350|M.smegmatis_MC2_155 IGQLETFVAKTNDQTGDIIEATEKLNRLTGKFAAQQPVVDKAVRTIPDAL
Mflv_0648|M.gilvum_PYR-GCK LTQLDTFTANVNGQIGDIIAATQSLNDLVAQFAAQKPIIDKALETIPDAL
TH_4336|M.thermoresistible__bu MSRLETFTSRINDQTDDVIAATEALNRLVAQFSSQRPVVDKALDTIPAAL
MAV_2536|M.avium_104 LNQLDTFVGYLNDQKSDIIAATDHLNNLVGQFADQKPIIDKALKTIPQAL
MAB_4149c|M.abscessus_ATCC_199 LPKLATLISSLNSQRDDIISAIEGIDKFSRVLAEHKESLGRAIDSIEPAL
Mb0179|M.bovis_AF2122/97 LGKLDTFTDELNQQRDDITRAIDSTNRLLAYVGGRSEVLNRVLTDLPPLI
MLBr_02593|M.leprae_Br4923 LTKLDTFASQLNQQRDDITHAIDSTNRLLTYVGGRSDVLDQILTDIPPLI
: :* : * .*: * : : : .. : ..: : : :
Mvan_3978|M.vanbaalenii_PYR-1 AVLDGERQNLIETADQFGKFSALTVDTVNKTKDNLVKELNDVGPVLESLA
Rv1970|M.tuberculosis_H37Rv AVLADERDTLVEAAEQLSKFSALTVDSVNKTTANLVTELRQLGPVLESLA
MMAR_4055|M.marinum_M AVLKNERENLADALTQLGRFSALAADSVNQTKDALVQELKDLGPTLESLA
MUL_3922|M.ulcerans_Agy99 TVLKNERENLADALTQLGRFSALAADSVNQTKDALVQELKDLGPTLESLA
MSMEG_0350|M.smegmatis_MC2_155 EVLKDQRDNLTAALDQLGRFSALAADSTRQTKDSLVREFRNIGPVLESLA
Mflv_0648|M.gilvum_PYR-GCK AVINAERDQLVEAVDQLGKFSALAADTVNQSQESLIQILNDMGPVLESLA
TH_4336|M.thermoresistible__bu AVLNSEREELIEAVEELGTFNELAADTIDQTRDAVVEELRDMGPVLESLA
MAV_2536|M.avium_104 TVLKDERENLANALGEVGQLSALAADSVNKTKENLIKELKDLGPVLQSLA
MAB_4149c|M.abscessus_ATCC_199 KVLNENRANIIEAFRSVGNLAKITDRVLRTTKDDIVADLKGLYPVVRALA
Mb0179|M.bovis_AF2122/97 KHFADKQELLINASDAVGRLSQSADQYLSAARGDLHQDLQALQCPLKELR
MLBr_02593|M.leprae_Br4923 KHFADTKNLLINAVGSVGQLSQAVDQYLSEARGPLHTDLQALACPLRELG
: : : : .. : . : : :. : :. *
Mvan_3978|M.vanbaalenii_PYR-1 DAGPSMTRALSLIPTFPFPNETIEKWQRGDYANLTAIADLTLSRIDAGMF
Rv1970|M.tuberculosis_H37Rv NSGPALTRSLSLLATFPFPNETFQNFQRGEYANLTAIVDLTLSRIDQGLL
MMAR_4055|M.marinum_M NAGPALTRALSFLPTYPFPKETLTNWMRGDYANLTLIIDMTLSRIDAGFF
MUL_3922|M.ulcerans_Agy99 NAGPALTRALSFLPTYPFPKETLTNWMRGDYANLTLIIDMTLSRIDAGFF
MSMEG_0350|M.smegmatis_MC2_155 NAGPNMTRALSILTTYPFPNETLEKWLRGDYGNMTAIVDLTLSRIDAGFF
Mflv_0648|M.gilvum_PYR-GCK NAGPALTRSLNLFTTIPFVKDNLTKWWRGDYANITTIVDLTLSRIDAGLF
TH_4336|M.thermoresistible__bu NAGPALTRSLSLFTTFPFPKETLTKWMRGDYANITVVADLTLSRMDSALF
MAV_2536|M.avium_104 DAGPALTRSLGFLGTFPFPAETLSKWIRGDYANLTAVIDLTLSRLDASFL
MAB_4149c|M.abscessus_ATCC_199 ENRDVLIDSLDLLPTFPFSTKYLRNAVRGDYLNVFVTFDLTARRLGETLF
Mb0179|M.bovis_AF2122/97 RAAPYLVGALKLILTQPFDVDTVPQLVRGDYMNLSLTLDLTYSAIDNAFL
MLBr_02593|M.leprae_Br4923 RGAPYFIGAMKLILTQPYDVDTVPKIMRGDYQNVSLTLDVTYSAMDNAVL
: :: :: * *: . . : **:* *: *:* :. .:
Mvan_3978|M.vanbaalenii_PYR-1 TGTRWEGDLTELELQWG---RTIGQFPSPYTR------ANPLTVPYRWD-
Rv1970|M.tuberculosis_H37Rv TGTRWECHLTQLELQWG---RTIGQFPSPCTAGYRGTPGNPLTIAYRWD-
MMAR_4055|M.marinum_M TGTRWEGDLTELELQWG---RTIGQMPSPYTVG------NPLIVPYRWD-
MUL_3922|M.ulcerans_Agy99 TGTRWEGDLTELELQWG---RTIGQMPSPYTVG------NPLIVPYRWD-
MSMEG_0350|M.smegmatis_MC2_155 TGTRWEGDLTELEMQWG---RTIGQLPSPYTAV------NPLVAPYRWD-
Mflv_0648|M.gilvum_PYR-GCK TGTRFEGHLTELELQWG---RTIGQLPSPYTAR------NPLIVPYRLD-
TH_4336|M.thermoresistible__bu TGTRWEGDLTELEMQWG---RTIGQLPSPYTAA------NPLLAPYRWN-
MAV_2536|M.avium_104 TGTRFECNLTELELQWG---RTIGQLPSPCTGGGPYNPGNPLVVPYHFD-
MAB_4149c|M.abscessus_ATCC_199 TTSFFDPNMQHFNDVVNPPEWLIGSMANLNGKE-----TSPFDLPAPAAP
Mb0179|M.bovis_AF2122/97 TGTGFSGALRALEQSFG--RDPETMIPDIRYTP------NPNDAPGGPLV
MLBr_02593|M.leprae_Br4923 TGTGLSGALRALEQSFG--RDPETMIPDVRYTT------NPNDAPGGPLV
* : . : :: . :.. .* .
Mvan_3978|M.vanbaalenii_PYR-1 QGP----
Rv1970|M.tuberculosis_H37Rv QGP----
MMAR_4055|M.marinum_M QGP----
MUL_3922|M.ulcerans_Agy99 QGP----
MSMEG_0350|M.smegmatis_MC2_155 QGR----
Mflv_0648|M.gilvum_PYR-GCK QGP----
TH_4336|M.thermoresistible__bu QGP----
MAV_2536|M.avium_104 QGR----
MAB_4149c|M.abscessus_ATCC_199 QGGGR--
Mb0179|M.bovis_AF2122/97 ERGNRQC
MLBr_02593|M.leprae_Br4923 ERADRRC
: