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MMWARWTTRIRIAAGIAALAVAVSGCSGWRGLNSLPLPGVQGGGPGSFTIQAQMPDVDNIEPNSRVRVGD VNVGTVTKIERQGWHALVTMKLNGNVELPANATATLGQTSLLGSLHIELAPPTDVPPEGNLREGSLIPLS SSKAYPSTEQALAATAMLLNGGGIGDIYDITEALSTAFTGRENDLRSLIEQLDEAIGHLDDQKGDIIAAA ESLNNLMAQLAAQRPVLDKALRTIPDALAVLKNERENLADALTQLGRFSALAADSVNQTKDALVQELKDL GPTLESLANAGPALTRALSFLPTYPFPKETLTNWMRGDYANLTLIIDMTLSRIDAGFFTGTRWEGDLTEL ELQWGRTIGQMPSPYTVGNPLIVPYRWDQGP
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_4055 | lprM_1 | - | 100% (381) | MCE family lipoprotein LprM |
| M. marinum M | MMAR_2886 | lprM | e-143 | 67.53% (385) | MCE family lipoprotein LprM |
| M. marinum M | MMAR_4706 | - | 5e-74 | 41.24% (354) | MCE family lipoprotein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0179 | lprK | 5e-69 | 40.55% (365) | MCE-family lipoprotein LprK |
| M. gilvum PYR-GCK | Mflv_2105 | - | 1e-165 | 75.52% (384) | virulence factor Mce family protein |
| M. tuberculosis H37Rv | Rv1970 | lprM | 1e-142 | 66.14% (378) | MCE-family lipoprotein LprM |
| M. leprae Br4923 | MLBr_02593 | lprK | 5e-61 | 36.50% (337) | putative lipoprotein |
| M. abscessus ATCC 19977 | MAB_4149c | - | 7e-62 | 39.70% (335) | MCE-family protein LprN |
| M. avium 104 | MAV_2536 | - | 1e-146 | 67.55% (376) | virulence factor Mce family protein |
| M. smegmatis MC2 155 | MSMEG_0350 | - | 1e-156 | 69.54% (371) | virulence factor Mce family protein |
| M. thermoresistible (build 8) | TH_4336 | - | 1e-151 | 66.93% (375) | PUTATIVE MCE-family lipoprotein LprM_1 |
| M. ulcerans Agy99 | MUL_3922 | lprM_1 | 0.0 | 99.21% (380) | MCE family lipoprotein LprM |
| M. vanbaalenii PYR-1 | Mvan_4600 | - | 1e-179 | 82.12% (386) | virulence factor Mce family protein |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_4055|M.marinum_M -------MMWARWTTRIRIAAGIAALAVAVSGCSGWRGLNSLPLPGVQGG
MUL_3922|M.ulcerans_Agy99 --------MRAGWTTRIRIAAGIAALAVAVSGCSGWRGLNSLPLPGVQGG
Mvan_4600|M.vanbaalenii_PYR-1 --------MRARAFRAIVVAA---VLAGLLSGCAGWRGLNSLPLPGVQGT
Mflv_2105|M.gilvum_PYR-GCK --------MTAVRASATMALAVTMAAAVTVSGCG-WRGLNSVPLPGTQGG
MAV_2536|M.avium_104 -------MSQSPLRRRVMAALLAAVALATLSGCG-FRGLNSFNLPGTKGG
Rv1970|M.tuberculosis_H37Rv ----------------MRIGLTLVMIAAVVASCG-WRGLNSLPLPGTQGN
MSMEG_0350|M.smegmatis_MC2_155 ---------MTHMRRVVACAATVAALMIGVTGCSNWRGLNSVSLPGTEGG
TH_4336|M.thermoresistible__bu ------------MRSATVSALALVVLSAALLAGCGWQGLNSVPLPGTQGR
MAB_4149c|M.abscessus_ATCC_199 ------------MSRNVLRAAVMGVGVAVVVSGCQFNGLNSLNLPGTAGH
Mb0179|M.bovis_AF2122/97 ---MMSVLARMRVMRHRAWQGLVLLVLALLLSSCGWRGISNVAIPGGPGT
MLBr_02593|M.leprae_Br4923 MRRAMSVVHTSRVR-HQTWRGLVMLVAALLLSSCGWRGISNVSIPGGPGS
: . :.*:... :** *
MMAR_4055|M.marinum_M GPGSFTIQAQMPDVDNIEPNSRVRVGDVNVGTVTKIERQ-----GWHALV
MUL_3922|M.ulcerans_Agy99 GPGSFTIQAQMPDVDNIEPNSRVRVGDVNVGTVTKIERQ-----GWHALV
Mvan_4600|M.vanbaalenii_PYR-1 GPGAFQIQAQMPEVDNIEPNSRVRVGDVNVGHVRKIERQ-----GWHALV
Mflv_2105|M.gilvum_PYR-GCK GPGSFTIQAQMPDVDNVEQNSRVRVGDVNVGTVSKIERQ-----GWNALV
MAV_2536|M.avium_104 GPGAYTIRAQMPDVQNLQRNSRVRVNDVTVGNVIDIELQ-----GWNALV
Rv1970|M.tuberculosis_H37Rv GPGSFAVQAQLPDVNNIQPNSRVRVADVTVGHVTKIERQ-----GWHALV
MSMEG_0350|M.smegmatis_MC2_155 GPGAFDIQVQMPDITNLQPNSRVRVADVTVGTVTKVERQ-----GWHALL
TH_4336|M.thermoresistible__bu GADAFTIQAQLPDVNNLQQNSRVRVGDVDVGTVAKIERQ-----GWHALV
MAB_4149c|M.abscessus_ATCC_199 GSRSYTVTVELPDVTTLPQNSPVMVDDVTVGSVSGIDAFQKPDGSWYAGV
Mb0179|M.bovis_AF2122/97 GPGSYTIYVQMPDTLAINGNSRVMVADVWVGSIRAIKLK-----NWVATL
MLBr_02593|M.leprae_Br4923 GKGAYTIYVQVPDTLAINGNSKVMVADVTVGSIRAINLK-----NWVATL
* :: : .::*: : ** * * ** ** : :. .* * :
MMAR_4055|M.marinum_M TMKLNGNVELPANATATLGQTSLLGSLHIELAPPTDVPPEGNLREGSLIP
MUL_3922|M.ulcerans_Agy99 TMKLNGNVELPANATATLGQTSLLGSLHIELAPPTDVPPEGNLREGSLIP
Mvan_4600|M.vanbaalenii_PYR-1 TIELNGDVELPANATATLGQTSLLGSLHIALAPPTDEAPQGRLKEGSLIP
Mflv_2105|M.gilvum_PYR-GCK TMTLNGDVNLPANATAKVGQTSLLGSQHIELAAPADEAPQGRLEEGTLIP
MAV_2536|M.avium_104 TMTIDGDVDLPANATATLGQTSLLGSVHVELAPPAGVAPQGKLKNGSLIP
Rv1970|M.tuberculosis_H37Rv TMRLDGDVDLPANATAKIGTTSLLGSYHIELAPPKGEARQGKLRDGSLIA
MSMEG_0350|M.smegmatis_MC2_155 TLRLNGDVNLPANCTATIGQTSLLGSLHVELAPPAAAPPQGRLHQGSLIP
TH_4336|M.thermoresistible__bu TIRLNGDVDLPANSTVTVGQTSLLGSLHVELAPPVDEPPQGSLRDGAFIP
MAB_4149c|M.abscessus_ATCC_199 KVSLEPEVHLPANAVAKVAQTSLLGSQHIELAAPVGEPAVGKLTGGATIP
Mb0179|M.bovis_AF2122/97 TLSLKKDVTLPKNATAKIGQTSLLGSQHVELAAPPD-PSPVPLKDGDTIP
MLBr_02593|M.leprae_Br4923 TLGLNKDVQLPKNTTAKIGQTSLLGSQHVELAAPAN-PSLELLKNGDTIP
.: :. :* ** * ...:. ****** *: **.* . * * *.
MMAR_4055|M.marinum_M LSSSKAYPSTEQALAATAMLLNGGGIGDIYDITEALSTAFTGRENDLRSL
MUL_3922|M.ulcerans_Agy99 LSSSKAYPSTEQALAATAMLLNGGGIGDIYDITEALSTAFTGRENDLRSL
Mvan_4600|M.vanbaalenii_PYR-1 LSSSRAYPSTEQALAAVALLLNGGGIGDIQDITEALSTAFTGRENDLRSL
Mflv_2105|M.gilvum_PYR-GCK LASAGAYPSTEQALAAVALLLNGGGLGNIQDITDALSTAFSGRENDLRSL
MAV_2536|M.avium_104 LSSAGAYPSTERTLAAVSLLLNGGGLGQVQDITKTLSTAFSGREQDLRNL
Rv1970|M.tuberculosis_H37Rv LSHGSAYPSTEQTLAALSLVLNGGGLGQVQDITEALSTAFAGREHDLRGL
MSMEG_0350|M.smegmatis_MC2_155 LADSTTHPTTEQTLAAVSMLLNGGGLGQMQDITKALSTALRGREADLRNL
TH_4336|M.thermoresistible__bu LDSGGAYPSTEQTLAAVSLLLNGGGLGQVQDITRALSTAFGGREDELRSL
MAB_4149c|M.abscessus_ATCC_199 LSRTGKYPSTEEVLSALSVVVNKGNLGALQDITDETYNLFKGRTGNLTQV
Mb0179|M.bovis_AF2122/97 LKRSSAYPTTEQTLASIATLLRGGGLVNLEGIQQEINAIVTGRADQIRAF
MLBr_02593|M.leprae_Br4923 LKNSSVFPTTEQTLASLSLILRGGGIPNLETLTNEVFNIFHGRADQIHAF
* .*:**..*:: : ::. *.: : : . ** :: .
MMAR_4055|M.marinum_M IEQLDEAIGHLDDQKGDIIAAAESLNNLMAQLAAQRPVLDKALRTIPDAL
MUL_3922|M.ulcerans_Agy99 IEQLDEAIGHLDDQKGDIIAAAESLNNLMAQLAAQRPVLDKALRTIPDAL
Mvan_4600|M.vanbaalenii_PYR-1 IEQLDKAIGYLDDQKDDIIAAAESLNNLMGQLAEQKPVVDKALRTIPDAL
Mflv_2105|M.gilvum_PYR-GCK IEQLDIAVGHLDDQTGDIIATSESLNNVVGQIAEQKPVVDKALRTIPDAL
MAV_2536|M.avium_104 LNQLDTFVGYLNDQKSDIIAATDHLNNLVGQFADQKPIIDKALKTIPQAL
Rv1970|M.tuberculosis_H37Rv IGQLDTFTAYLNNQSGDIIAATDSLNRLVGKFADQQPVFDRALATIPDAL
MSMEG_0350|M.smegmatis_MC2_155 IGQLETFVAKTNDQTGDIIEATEKLNRLTGKFAAQQPVVDKAVRTIPDAL
TH_4336|M.thermoresistible__bu MSRLETFTSRINDQTDDVIAATEALNRLVAQFSSQRPVVDKALDTIPAAL
MAB_4149c|M.abscessus_ATCC_199 LPKLATLISSLNSQRDDIISAIEGIDKFSRVLAEHKESLGRAIDSIEPAL
Mb0179|M.bovis_AF2122/97 LGKLDTFTDELNQQRDDITRAIDSTNRLLAYVGGRSEVLNRVLTDLPPLI
MLBr_02593|M.leprae_Br4923 LTKLDTFASQLNQQRDDITHAIDSTNRLLTYVGGRSDVLDQILTDIPPLI
: :* :.* .*: : : :.. .. : ..: : : :
MMAR_4055|M.marinum_M AVLKNERENLADALTQLGRFSALAADSVNQTKDALVQELKDLGPTLESLA
MUL_3922|M.ulcerans_Agy99 TVLKNERENLADALTQLGRFSALAADSVNQTKDALVQELKDLGPTLESLA
Mvan_4600|M.vanbaalenii_PYR-1 AVLKDQRNNLAEALTQLGRFSALAADSVNQTKEALVAELEDLGPVLEELA
Mflv_2105|M.gilvum_PYR-GCK AVLRDQRDTLSEALVQLGRFSALAADSVTKTREALIQELKDLGPVLQSLA
MAV_2536|M.avium_104 TVLKDERENLANALGEVGQLSALAADSVNKTKENLIKELKDLGPVLQSLA
Rv1970|M.tuberculosis_H37Rv AVLADERDTLVEAAEQLSKFSALTVDSVNKTTANLVTELRQLGPVLESLA
MSMEG_0350|M.smegmatis_MC2_155 EVLKDQRDNLTAALDQLGRFSALAADSTRQTKDSLVREFRNIGPVLESLA
TH_4336|M.thermoresistible__bu AVLNSEREELIEAVEELGTFNELAADTIDQTRDAVVEELRDMGPVLESLA
MAB_4149c|M.abscessus_ATCC_199 KVLNENRANIIEAFRSVGNLAKITDRVLRTTKDDIVADLKGLYPVVRALA
Mb0179|M.bovis_AF2122/97 KHFADKQELLINASDAVGRLSQSADQYLSAARGDLHQDLQALQCPLKELR
MLBr_02593|M.leprae_Br4923 KHFADTKNLLINAVGSVGQLSQAVDQYLSEARGPLHTDLQALACPLRELG
: . : : * :. : . : : ::. : :. *
MMAR_4055|M.marinum_M NAGPALTRALSFLPTYPFPKETLTNWMRGDYANLTLIIDMTLSRIDAGFF
MUL_3922|M.ulcerans_Agy99 NAGPALTRALSFLPTYPFPKETLTNWMRGDYANLTLIIDMTLSRIDAGFF
Mvan_4600|M.vanbaalenii_PYR-1 DAGPALTRALSFLPTFPFPKETLTNWMRGDYANLTLILDLTLSRIDSGFF
Mflv_2105|M.gilvum_PYR-GCK DAGPALTRALSFLPTFPFPKETLTNWMRGDYANLTLVVDLTLSRIDQGFF
MAV_2536|M.avium_104 DAGPALTRSLGFLGTFPFPAETLSKWIRGDYANLTAVIDLTLSRLDASFL
Rv1970|M.tuberculosis_H37Rv NSGPALTRSLSLLATFPFPNETFQNFQRGEYANLTAIVDLTLSRIDQGLL
MSMEG_0350|M.smegmatis_MC2_155 NAGPNMTRALSILTTYPFPNETLEKWLRGDYGNMTAIVDLTLSRIDAGFF
TH_4336|M.thermoresistible__bu NAGPALTRSLSLFTTFPFPKETLTKWMRGDYANITVVADLTLSRMDSALF
MAB_4149c|M.abscessus_ATCC_199 ENRDVLIDSLDLLPTFPFSTKYLRNAVRGDYLNVFVTFDLTARRLGETLF
Mb0179|M.bovis_AF2122/97 RAAPYLVGALKLILTQPFDVDTVPQLVRGDYMNLSLTLDLTYSAIDNAFL
MLBr_02593|M.leprae_Br4923 RGAPYFIGAMKLILTQPYDVDTVPKIMRGDYQNVSLTLDVTYSAMDNAVL
: :: :: * *: . . : **:* *: *:* :. .:
MMAR_4055|M.marinum_M TGTRWEGDLTELELQWGR-TIGQMPSPY------TVGNPLIVPYRWDQGP
MUL_3922|M.ulcerans_Agy99 TGTRWEGDLTELELQWGR-TIGQMPSPY------TVGNPLIVPYRWDQGP
Mvan_4600|M.vanbaalenii_PYR-1 TGSRWECDLTWLELQWGR-TIGQFPNPCNAGGPGTAGNPLIAPYRWDQGP
Mflv_2105|M.gilvum_PYR-GCK TGTRFECNLTWLELQWGR-TIGQTPSPCNHNVPPPGSNPLVAPYRWDQGR
MAV_2536|M.avium_104 TGTRFECNLTELELQWGR-TIGQLPSPCTGGGPYNPGNPLVVPYHFDQGR
Rv1970|M.tuberculosis_H37Rv TGTRWECHLTQLELQWGR-TIGQFPSPCTAGYRGTPGNPLTIAYRWDQGP
MSMEG_0350|M.smegmatis_MC2_155 TGTRWEGDLTELEMQWGR-TIGQLPSPY------TAVNPLVAPYRWDQGR
TH_4336|M.thermoresistible__bu TGTRWEGDLTELEMQWGR-TIGQLPSPY------TAANPLLAPYRWNQGP
MAB_4149c|M.abscessus_ATCC_199 TTSFFDPNMQHFNDVVNP-PEWLIGSMANLNGKETSPFDLPAPAAPQGGG
Mb0179|M.bovis_AF2122/97 TGTGFSGALRALEQSFGRDPETMIPDIRYTPNPNDAPGGPLVERGNRQC-
MLBr_02593|M.leprae_Br4923 TGTGLSGALRALEQSFGRDPETMIPDVRYTTNPNDAPGGPLVERADRRC-
* : . : :: . . .
MMAR_4055|M.marinum_M -
MUL_3922|M.ulcerans_Agy99 -
Mvan_4600|M.vanbaalenii_PYR-1 -
Mflv_2105|M.gilvum_PYR-GCK -
MAV_2536|M.avium_104 -
Rv1970|M.tuberculosis_H37Rv -
MSMEG_0350|M.smegmatis_MC2_155 -
TH_4336|M.thermoresistible__bu -
MAB_4149c|M.abscessus_ATCC_199 R
Mb0179|M.bovis_AF2122/97 -
MLBr_02593|M.leprae_Br4923 -