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MKISLFYEFALPRPWAPDDEHVLLQECLDEVEAADKAGFSTVWLTEHHFLEEYCHSTAPEIFLAAASQRT ENIRLGFGIMHLPPAVNHPARVAERIATLDLLSNGRVEFGTGESSSVGELGGFNIDPADKRAQWEEALEV AIRCMVEEPFSGFHGEHVQMPARNVIPKPLQKPHPPVWVACTRPASVQMAAQKAIGALSFAYTGPGPLTE RVNGYYKEFEENGVPVTPAINPNILAIGGDLSMMVAKTDEEALQRLGKGGGFFSFGIMHYYMTGVHTPGR TGVWKRYLEEVEKDPTLAYGPGRGAIGSPATVREFLRGYEESGVDEIILLLNPRSHEGTMESIELMGKEV LPEFIERDAKAVADKATRLAPVIEKVEARRPKSTAPQFDENYSFGGLPTGRGGKFTASEIPEAMAEINEG RVQAAQRAKEQQQQKK
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_0881 | - | - | 100% (436) | hypothetical protein MAV_0881 |
| M. avium 104 | MAV_2779 | - | 1e-21 | 26.56% (369) | limonene 1,2-monooxygenase |
| M. avium 104 | MAV_0538 | - | 5e-21 | 32.98% (188) | limonene 1,2-monooxygenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1971 | - | 6e-18 | 27.12% (354) | monooxygenase |
| M. gilvum PYR-GCK | Mflv_2404 | - | 0.0 | 82.80% (436) | luciferase family protein |
| M. tuberculosis H37Rv | Rv3618 | - | 1e-20 | 32.45% (188) | monooxygenase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0527c | - | 3e-24 | 28.16% (348) | monooxygenase |
| M. marinum M | MMAR_4774 | - | 0.0 | 92.61% (433) | monoxygenase |
| M. smegmatis MC2 155 | MSMEG_4863 | - | 0.0 | 85.22% (433) | hypothetical protein MSMEG_4863 |
| M. thermoresistible (build 8) | TH_3770 | - | 0.0 | 86.54% (431) | PUTATIVE luciferase family protein |
| M. ulcerans Agy99 | MUL_0345 | - | 0.0 | 92.15% (433) | monoxygenase |
| M. vanbaalenii PYR-1 | Mvan_4242 | - | 0.0 | 82.57% (436) | luciferase family protein |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_4774|M.marinum_M MKIS--LFYEFALPRPWAPDDERIMLQDCLDEVEAADKAGFSTVWLTEHH
MUL_0345|M.ulcerans_Agy99 MKIS--LFYEFALPRPWAPNDERIMLQDCLDEVEAADKAGFSTVWLTEHH
MAV_0881|M.avium_104 MKIS--LFYEFALPRPWAPDDEHVLLQECLDEVEAADKAGFSTVWLTEHH
Mflv_2404|M.gilvum_PYR-GCK MKIS--LFYEFPLPRPWSDDDEHQLFQHGLDEVELADKAGFSTVWLTEHH
Mvan_4242|M.vanbaalenii_PYR-1 MKIS--LFYEFPLPRPWSEDDEHQLFQHGLDEVELADKAGFSTVWLTEHH
MSMEG_4863|M.smegmatis_MC2_155 MKIS--LFYEFPLPRPWSEDDEHQLFQHGLDEVELADKAGFSTVWLTEHH
TH_3770|M.thermoresistible__bu MKIS--LFYEFPLPRPWSEDDEHKLFQDGLDEVEAADKAGFSSVWLTEHH
Rv3618|M.tuberculosis_H37Rv MKAP-LRFGVFITPFHPTGQSPTVALQYDMERVVALDRLGYDEAWFGEHH
MAB_0527c|M.abscessus_ATCC_199 MSAPPLRFGAFITPFHPVGQNPTTALEYDLDRVVALDRLGYHEAWFGEHH
Mb1971|M.bovis_AF2122/97 MEIG-----IFLMPAHPPERTLYDATRWDLDVIELADQLGYVEAWVGEHF
*. * * . :: : *: *: .*. **.
MMAR_4774|M.marinum_M FLEEYCHSTAPEIFLAAASQRTKNIRLGFGIMHLPPAVNHPARVAERIAT
MUL_0345|M.ulcerans_Agy99 FLEEYCHSTAPEIFLAAASQRTKNIRLGFGIMHLPPAVNHPARVAERIAT
MAV_0881|M.avium_104 FLEEYCHSTAPEIFLAAASQRTENIRLGFGIMHLPPAVNHPARVAERIAT
Mflv_2404|M.gilvum_PYR-GCK FLEEYCHSTAPELFLAAASQRTKNIRLGFGVMHLPPPINHPARIAERVAT
Mvan_4242|M.vanbaalenii_PYR-1 FLEEYCHSTAPELFLAAASQRTKNIRLGFGVMHLPPPINHPARIAERVAT
MSMEG_4863|M.smegmatis_MC2_155 FLEEYCHSTAPEMFLAAASQRTENIRLGFGVMHLPPPINHPARIAERVAT
TH_3770|M.thermoresistible__bu FLEEYCHSTAPEMFLAAASQRTENIRLGFGVMHLPPPINHPARIAERVAT
Rv3618|M.tuberculosis_H37Rv S-GGYELIACPEVFIAAAAERTTHIRLGTGVVSLP--YHHPLMVADRWVL
MAB_0527c|M.abscessus_ATCC_199 S-GGYELISCPEVFIATAAERTKHIKLGTGVVSLP--YHHPLMVVDRWIL
Mb1971|M.bovis_AF2122/97 T-VPWEPICAPDLLLAQALLRTQQIKLAPGAHLLP--YHHPVELAHRVAY
: .*::::* * ** :*:*. * ** :** :..*
MMAR_4774|M.marinum_M LDLLSNGRVEFGTGESSSIGELGGFNIDP--ADKRGQWEEALEVAIRCMI
MUL_0345|M.ulcerans_Agy99 LDLLSNGRVEFGTGESSSIGELGGFNIDP--TDKRGQWEEALEVAIRCMI
MAV_0881|M.avium_104 LDLLSNGRVEFGTGESSSVGELGGFNIDP--ADKRAQWEEALEVAIRCMV
Mflv_2404|M.gilvum_PYR-GCK LDHLSNGRVEFGTGEGSSVAELGGFNIDP--ADKRAQWEEALEVSIRCMT
Mvan_4242|M.vanbaalenii_PYR-1 LDHLSNGRVEYGTGEGSSVAELGGFNIDP--ADKRTMWEEALEVSIRCMT
MSMEG_4863|M.smegmatis_MC2_155 LDHLSNGRVEFGTGEGSSVAELGGFNIDP--ADKRTQWEESLEVAIRCMV
TH_3770|M.thermoresistible__bu LDHLSNGRVEFGTGEGSSVAELGGFNIDP--ADKRTMWEEALEVSIRCMI
Rv3618|M.tuberculosis_H37Rv LDHLTRGRVMFGTGPGALPSDAYMMGIDP--VEQRRMMQESLEAILALFR
MAB_0527c|M.abscessus_ATCC_199 LDHITRGRVIFGTGPGALPTDAYMMGIDP--VDQRRMQEESLEAILALLR
Mb1971|M.bovis_AF2122/97 FDHLAQGRFMLGVGASGIPGDWALYDVDGKNGEHREMTREALEIMLRIWT
:* ::.**. *.* .. : .:* ::* .*:** :
MMAR_4774|M.marinum_M EEPFAGFT--GDHIQMP--------ARNVIPKPMQKPHPPVWVACTR--P
MUL_0345|M.ulcerans_Agy99 EEPFAGFT--GDHIQMP--------ARNVIPKPMQKPHPPVWVACTR--P
MAV_0881|M.avium_104 EEPFSGFH--GEHVQMP--------ARNVIPKPLQKPHPPVWVACTR--P
Mflv_2404|M.gilvum_PYR-GCK EAPFTGFK--GEHVEMP--------ARNVIPKPLQQPHPPVWVACTR--P
Mvan_4242|M.vanbaalenii_PYR-1 EAPFTGFK--GEHVEMA--------ARNVIPKPLQQPHPPVWVACTR--P
MSMEG_4863|M.smegmatis_MC2_155 EEPFSGFK--GEHVEMP--------ARNVIPKPLQKPHPPVWVACTR--P
TH_3770|M.thermoresistible__bu EEPFSGFK--GEHVEMP--------ARNVIPKPLQKPHPPVWVACTR--P
Rv3618|M.tuberculosis_H37Rv AAPDERIDRHSDWFTLR--------EAQLHIRPYTWPYPEIATAAMIS-P
MAB_0527c|M.abscessus_ATCC_199 ATPQERINRETSWFTLR--------DAQLQLRPYTHPYPEILTAAMFS-P
Mb1971|M.bovis_AF2122/97 EDEPWEHR--GKYWNANGIAPMFEGLMRRHIKPYQKPHPPIGVTGFSAGS
. . :* *:* : .: .
MMAR_4774|M.marinum_M ATVQMAAQKCIGALSFAYTGPGPLTERVNGYYKEFEENGTPVTPAINPNI
MUL_0345|M.ulcerans_Agy99 ATVQMAAQKCIGALSFAYTGPGPLTERVNGYYKEFEENGTPVTPAINPNI
MAV_0881|M.avium_104 ASVQMAAQKAIGALSFAYTGPGPLTERVNGYYKEFEENGVPVTPAINPNI
Mflv_2404|M.gilvum_PYR-GCK SSVGMAAEKAIGALSFAYTGPEALKDRVDGYYKDFEEKGTPITPAINPNL
Mvan_4242|M.vanbaalenii_PYR-1 SSVQMAAQKAIGALSFAYTGPEALKERVDGYYKEFEEQGAPITPAINPNI
MSMEG_4863|M.smegmatis_MC2_155 SSVQMAAQKAIGALSFAYTGPEALKERVAGYYKEFEEQGAPVTPAINPNI
TH_3770|M.thermoresistible__bu SSVQMAAQKAIGALSFAYTGPGPLKERVDGYYKEFEEKGSPVTPAVNPNI
Rv3618|M.tuberculosis_H37Rv SGPRLAGALGTSLLSLSMSVPGGYAALETAWGVVREQAAKAGRGEPDRAD
MAB_0527c|M.abscessus_ATCC_199 SGPRLAGKLGAGLLSLSASIPGGFAALENAWEVVREQAEIHGHPEPDRSS
Mb1971|M.bovis_AF2122/97 ETLKLAGERGYIPMSLDLN-----TEYVATHWDAVEEGALRSGRTPDRRD
:*. :*: . *: :
MMAR_4774|M.marinum_M LAIGGDLSMMVAKTDEQALQRLG-QGGGFFSFGIMHYYMTGIHTPGRTG-
MUL_0345|M.ulcerans_Agy99 LAIGGDLSMMVAKTDEQALQRLG-QGGGFFSFGIMHYYMTGIHTPGRTG-
MAV_0881|M.avium_104 LAIGGDLSMMVAKTDEEALQRLG-KGGGFFSFGIMHYYMTGVHTPGRTG-
Mflv_2404|M.gilvum_PYR-GCK LAIGGDLSMMVAKTDEEALKRLG-IGGGFFSFGIMHYYLTGMHTPGRTG-
Mvan_4242|M.vanbaalenii_PYR-1 LAIGGDLSMMVAKTDEEALERLG-IGGGFFSFGIMHYYLTGMHTPGRTG-
MSMEG_4863|M.smegmatis_MC2_155 LAIGGDLSMMVARTDEEALKRLG-IGGGFFSFGIMHYYLTGMHTPGRTK-
TH_3770|M.thermoresistible__bu LAIGGDLSMMVAKTDEEALKRLG-IGGGFFSFGIMHYYMTGMHTPGRTG-
Rv3618|M.tuberculosis_H37Rv WRVLSIMHLSDSRDQAIDDCTYG-LPDFSRYFGAAGFVPLANTVEGTQ--
MAB_0527c|M.abscessus_ATCC_199 WRVLGIMHLAETRDQAIADCTYG-LPDYAHYFGAVGVLPLANSADGADGA
Mb1971|M.bovis_AF2122/97 WRLVREVLVAETDEQAFRYAVDGTMGRAMREYVLPTFRMFGMTKFYKHNP
: : : : : * : .
MMAR_4774|M.marinum_M --VWTRYLEEIEKDPTLAYGPGRGAIGCPATVREFLRGYEESGVDEIILL
MUL_0345|M.ulcerans_Agy99 --VWTRYLEEIEKDPTLAYGPGRGAIGCPATVREFLRGYEESGVDEIILL
MAV_0881|M.avium_104 --VWKRYLEEVEKDPTLAYGPGRGAIGSPATVREFLRGYEESGVDEIILL
Mflv_2404|M.gilvum_PYR-GCK --VWELYEKAVKEDPTLAYGPGRGAIGSPETVREFLRGYEASGVDEIILL
Mvan_4242|M.vanbaalenii_PYR-1 --VWELYEKAVKEDPTLAYGPGRGAIGSPDTVREFLRGYEASGVDEIILL
MSMEG_4863|M.smegmatis_MC2_155 --VWERYEQAVADDPTLAYGPGRGAIGSPETVREFLRGYEASGVDEIILL
TH_3770|M.thermoresistible__bu --VWELYEQAVKEDPTLAYGPGRGAIGSPETVREFLRGYEESGVDEIILL
Rv3618|M.tuberculosis_H37Rv --SSREFVEQYAAKGNCCIGTPDDAIAHIEDLLHRSGGFG----TLLLLG
MAB_0527c|M.abscessus_ATCC_199 -IDPHEFVKAYADEGNCCIGTPEDAIEYIQGLLDTSGGFG----TFLMLG
Mb1971|M.bovis_AF2122/97 SVPDDEVTPEYLAENTFVVGSVQTVVDKLEATYDQVGGFG----HLLILG
. . *. .: . *: ::*
MMAR_4774|M.marinum_M LNPRSHEGTMES-IELMGKEVLPEFIERDAKAVADKAVRLAPAIEKVQAR
MUL_0345|M.ulcerans_Agy99 LNPRSHEGTMES-IELMGKEVLPEFIERDAKAVADKAVRLAPAIEKVQAR
MAV_0881|M.avium_104 LNPRSHEGTMES-IELMGKEVLPEFIERDAKAVADKATRLAPVIEKVEAR
Mflv_2404|M.gilvum_PYR-GCK LNPRSHEGTMES-IEIMGRDILPEFIERDEKAVKDKAKRLEPVIEKVEAR
Mvan_4242|M.vanbaalenii_PYR-1 LNPRSHEGTMES-IEIMGRDILPEFIERDEKAVKDKAKRLEPVIEKVEAR
MSMEG_4863|M.smegmatis_MC2_155 LNPRSHEGTMES-IEIMGKEILPEFIERDEKAVKDKAERLEPVVEKVESR
TH_3770|M.thermoresistible__bu LNPRSHEGTMES-IEIMGREILPEFIEREEKAQVEKAKRLEPVLEKVEAR
Rv3618|M.tuberculosis_H37Rv HDWAPPPATFHS-YELFARAVIPYFKG--------QLAAPRASHEWARGK
MAB_0527c|M.abscessus_ATCC_199 HDWAAPEATFKS-YELFARKVIPHFTG--------QLTAAQASHDWAQAK
Mb1971|M.bovis_AF2122/97 FDYSDNPGPWKESLRLLAHEVMPRLNAR---------LATKPATAVV---
: .. .. .::.: ::* : . .
MMAR_4774|M.marinum_M RQESNAPQFDEAYSFGGLPTGRGGKFTASEIPEAMAEINEGRVQAAQRLK
MUL_0345|M.ulcerans_Agy99 RQESNAPQFDEAYSFGGLPTGRGGKFTASEIPEAMAEINEGRVQAAQRLK
MAV_0881|M.avium_104 RPKSTAPQFDENYSFGGLPTGRGGKFTASEIPEAMAEINEGRVQAAQRAK
Mflv_2404|M.gilvum_PYR-GCK RQSWDAPMFDETYSFGGLPTGRGGKFTAGEIPEAMAEINEGRVKAAQAEK
Mvan_4242|M.vanbaalenii_PYR-1 RQSWDAPLFDETYAFGGLPTGRGGKFTAGEIPEAMAEINEGRVKAAQAEK
MSMEG_4863|M.smegmatis_MC2_155 RQGSDAPLFDETYAFGGLPTGRGGKFTAGEIPEAMAEINEGRVKAAQAEK
TH_3770|M.thermoresistible__bu RKPSEAPEFDETYSFGGLPTGRGGKFTASEIPEAMAEINEGRVQAAKKAK
Rv3618|M.tuberculosis_H37Rv R---------------DQLIGRAGEAVVKAITEHVAEQGEAGS-------
MAB_0527c|M.abscessus_ATCC_199 R---------------GELLGRAGDAVAKAIGEHVAQKASH---------
Mb1971|M.bovis_AF2122/97 --------------------------------------------------
MMAR_4774|M.marinum_M ------EQRK---
MUL_0345|M.ulcerans_Agy99 ------EQRK---
MAV_0881|M.avium_104 ------EQQQQKK
Mflv_2404|M.gilvum_PYR-GCK DARAAKEAAG---
Mvan_4242|M.vanbaalenii_PYR-1 DAKAAKEAAS---
MSMEG_4863|M.smegmatis_MC2_155 ---AAREAAG---
TH_3770|M.thermoresistible__bu ------EQAS---
Rv3618|M.tuberculosis_H37Rv -------------
MAB_0527c|M.abscessus_ATCC_199 -------------
Mb1971|M.bovis_AF2122/97 -------------