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RFGNFMAPFHPVGQNPTLALERDLDLIAAMDRLGFHEAWVGEHHSAGFEIIASPEVFIGIAAERTKHIKL GTGVSSLPYHHPLLLADRMVLLDHLTRGRVMLGCGPGQLTSDAHMLGIPADAQRPRMEQSLDAIVRLLRG ETVTMHTDGFTLQDARLQLKPYSDPCFDIAVAASFSPTGPRGAGRHGIGMLSIAATAKQGMDLLAQHWNT WEEVAREHGHVADRAKWRLVGPMHLAETREQAERDVEYGIAQFSQYFSHILPAGPVQGDTPAEIIANNHA SGFAVIGTPQDAIAKIEELVEASNGGFGTFLLFDHDWAPPAAKLRSYELFAEYVIPHFTGQLSAPIASRD WVTESGRTFVDQAAHAIGKAIEDHAAEQQAKSPTPS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_1925 | - | - | 100% (387) | luciferase family protein |
| M. vanbaalenii PYR-1 | Mvan_4004 | - | 4e-34 | 30.11% (372) | luciferase family protein |
| M. vanbaalenii PYR-1 | Mvan_4242 | - | 8e-18 | 31.35% (185) | luciferase family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1971 | - | 1e-35 | 30.24% (377) | monooxygenase |
| M. gilvum PYR-GCK | Mflv_4429 | - | 0.0 | 91.73% (387) | luciferase family protein |
| M. tuberculosis H37Rv | Rv3618 | - | 1e-107 | 51.68% (387) | monooxygenase |
| M. leprae Br4923 | MLBr_00131 | - | 2e-07 | 27.59% (174) | putative oxidoreductase |
| M. abscessus ATCC 19977 | MAB_0527c | - | 1e-112 | 53.08% (390) | monooxygenase |
| M. marinum M | MMAR_5115 | - | 1e-105 | 50.64% (393) | monooxygenase |
| M. avium 104 | MAV_0538 | - | 1e-106 | 51.55% (388) | limonene 1,2-monooxygenase |
| M. smegmatis MC2 155 | MSMEG_6107 | - | 1e-108 | 51.66% (391) | limonene 1,2-monooxygenase |
| M. thermoresistible (build 8) | TH_0993 | - | 1e-108 | 51.28% (390) | POSSIBLE MONOOXYGENASE |
| M. ulcerans Agy99 | MUL_2949 | - | 3e-98 | 54.78% (345) | monooxygenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_1925|M.vanbaalenii_PYR-1 -----MRFGNFMAPFHPVGQNPTLALERDLDLIAAMDRLGFHEAWVGEHH
Mflv_4429|M.gilvum_PYR-GCK -----MRFGNFMAPFHPVGQNPTLALERDLDLIVAMDRLGFHEAWVGEHH
MUL_2949|M.ulcerans_Agy99 --MAKLRFGYFIAPFHRAGTNPTLALQRDLEFVEHLDALGFDEAWIGEHH
MSMEG_6107|M.smegmatis_MC2_155 --MRPLNFGVFITPFHPAGQSPTTALQYDMDRVEALDRLGYDEAWFGEHH
TH_0993|M.thermoresistible__bu -VARPLNFGVFITPFHPVGQSPTLALEYDLERTVALDRLGYDEVWFGEHH
Rv3618|M.tuberculosis_H37Rv -MKAPLRFGVFITPFHPTGQSPTVALQYDMERVVALDRLGYDEAWFGEHH
MMAR_5115|M.marinum_M MTDAPLKFGVFITPFHPTGQSPTVALEYDMERVVALDRLGYDEAWFGEHH
MAV_0538|M.avium_104 -MSAPLRFGVFITPFHPVGQSPTVALEYDLERVVALDRLGFDEAWFGEHH
MAB_0527c|M.abscessus_ATCC_199 MSAPPLRFGAFITPFHPVGQNPTTALEYDLDRVVALDRLGYHEAWFGEHH
Mb1971|M.bovis_AF2122/97 -----MEIGIFLMPAHPPERTLYDATRWDLDVIELADQLGYVEAWVGEHF
MLBr_00131|M.leprae_Br4923 --MAGFRFG-FVDALVHTLFPPSLPAR---ASIVSGAVLGADSYWVGDHL
:.:* *: . . . ** . *.*:*
Mvan_1925|M.vanbaalenii_PYR-1 SAGFEIIASPEVFIGIAAERT----------------------KHIKLGT
Mflv_4429|M.gilvum_PYR-GCK SAGFEIIASPEVFLGVAAERT----------------------KHIRLGT
MUL_2949|M.ulcerans_Agy99 SAGSEIISSPEVFIAAAAERT----------------------KRIRLGT
MSMEG_6107|M.smegmatis_MC2_155 SGGYELIACPEVFIAAAAERT----------------------RHIRLGT
TH_0993|M.thermoresistible__bu SGGYELIASPEVFIAAAAERT----------------------RHVRLGT
Rv3618|M.tuberculosis_H37Rv SGGYELIACPEVFIAAAAERT----------------------THIRLGT
MMAR_5115|M.marinum_M SGGYELIACPEVFIAAAAERT----------------------KHIRLGT
MAV_0538|M.avium_104 SGGYELIACPEVFIATAAERT----------------------KHIRLGT
MAB_0527c|M.abscessus_ATCC_199 SGGYELISCPEVFIATAAERT----------------------KHIKLGT
Mb1971|M.bovis_AF2122/97 TVPWEPICAPDLLLAQALLRT----------------------QQIKLAP
MLBr_00131|M.leprae_Br4923 NALVPRSVATPKYLGVAAKVVPKIDANYEPWTMLGNLAAGNRLNGLRLGV
. .. :. * . ::*.
Mvan_1925|M.vanbaalenii_PYR-1 GVSSLPYHHPLLLADRMVLLDHLTRGRVMLGCGPGQLTSDAHMLGIPAD-
Mflv_4429|M.gilvum_PYR-GCK GVSSLPYHHPLMLADRMVLLDHLTRGRVMLGCGPGQLTSDAHMLGIPAD-
MUL_2949|M.ulcerans_Agy99 GVISLAYHNPLWVADRLMLLDHLTHGRVIGGMGPGSLATDSAMIGLTPT-
MSMEG_6107|M.smegmatis_MC2_155 GVVSLPYHHPLMVADRWVLLDHLTRGRVMFGTGPGALPSDAYMMGIDPV-
TH_0993|M.thermoresistible__bu GVVSLPYHHPLMVADRWVLLDHITRGRVMFGAGPGALPSDAYMMGIDPV-
Rv3618|M.tuberculosis_H37Rv GVVSLPYHHPLMVADRWVLLDHLTRGRVMFGTGPGALPSDAYMMGIDPV-
MMAR_5115|M.marinum_M GVVSLPYHHPLMVADRWVLLDHLTRGRVMFGTGPGALPSDAYMMGIDPI-
MAV_0538|M.avium_104 GVVSLPYHHPLMVADRWVLLDHLTRGRVMFGTGPGALPSDAYMMGIDPV-
MAB_0527c|M.abscessus_ATCC_199 GVVSLPYHHPLMVVDRWILLDHITRGRVIFGTGPGALPTDAYMMGIDPV-
Mb1971|M.bovis_AF2122/97 GAHLLPYHHPVELAHRVAYFDHLAQGRFMLGVGASGIPGDWALYDVDGKN
MLBr_00131|M.leprae_Br4923 CVTDAGRRNPAVTAQAAATLHLLTRGKAMLGIGVGEREGNE-PYGVEWT-
. ::* .. :. :::*: : * * . : .:
Mvan_1925|M.vanbaalenii_PYR-1 -AQRPRMEQSLDAIVRLLRG---ETVTMHTDGFTLQ--------DARLQL
Mflv_4429|M.gilvum_PYR-GCK -EQRPRMEQCLDAIVRLLRG---ETVTMHTDGFTLQ--------DARLQL
MUL_2949|M.ulcerans_Agy99 -DTRELLETNLDIVVRLLAG---QTVTAKTATHQLF--------DARLQL
MSMEG_6107|M.smegmatis_MC2_155 -DQRPMMQESLEAILALFRAEPGERIDRKTDWFTLR--------DAALHI
TH_0993|M.thermoresistible__bu -NQRPMMQEALEAILALLRAAPDERISRETDWFTLR--------DAQLHI
Rv3618|M.tuberculosis_H37Rv -EQRRMMQESLEAILALFRAAPDERIDRHSDWFTLR--------EAQLHI
MMAR_5115|M.marinum_M -DQRRMMQESLEAILALLRAAPGERIDRHSDWFTLR--------DAQLHI
MAV_0538|M.avium_104 -DQRHMMQESLEAILALFRAAPTERIDRHSDWFTLR--------DAQLHI
MAB_0527c|M.abscessus_ATCC_199 -DQRRMQEESLEAILALLRATPQERINRETSWFTLR--------DAQLQL
Mb1971|M.bovis_AF2122/97 GEHREMTREALEIMLRIWTE--DEPWEHRGKYWNANGIAPMFEGLMRRHI
MLBr_00131|M.leprae_Br4923 -KPVARFQEALATIRALWDSN-GELVSRESQFFPLH--------NALFDL
. * : : : . .:
Mvan_1925|M.vanbaalenii_PYR-1 KPYSDPCFDIAVAASFS-PTGPRGAGRHGIGMLSIAAT-AKQGMDLLAQH
Mflv_4429|M.gilvum_PYR-GCK KPYSEPCFDIAVAASFS-PTGPRGAGRHGIGMLSIAAT-ARQGMDLLAQH
MUL_2949|M.ulcerans_Agy99 APFSEGGIPLAVAAVAS-PTGARLAGRHGIGLLSIGATLTIEGFDALAYH
MSMEG_6107|M.smegmatis_MC2_155 RPYTWPYPEISTAAMIS-PSGPRLAGKLGTSLLSLSMS-VPGGYAAVETT
TH_0993|M.thermoresistible__bu RPYTWPYPEISTAAMIS-PSGPRLAGSLGTSLLSLSMS-VPGGYAAVENT
Rv3618|M.tuberculosis_H37Rv RPYTWPYPEIATAAMIS-PSGPRLAGALGTSLLSLSMS-VPGGYAALETA
MMAR_5115|M.marinum_M RPYTWPYPEISTAAMIS-PSGPRLAGSLGTSLLSLSMS-VPGGYAALENT
MAV_0538|M.avium_104 RPYTWPYPEISTAAMIS-PSGPRLAGALGTSLLSLSMS-VPGGYAALETT
MAB_0527c|M.abscessus_ATCC_199 RPYTHPYPEILTAAMFS-PSGPRLAGKLGAGLLSLSAS-IPGGFAALENA
Mb1971|M.bovis_AF2122/97 KPYQKPHPPIGVTGFSAGSETLKLAGERGYIPMSLDLN-----TEYVATH
MLBr_00131|M.leprae_Br4923 PPYRGKWPEIWVAAHGP--RMLQATGRYADAWIPIVLV----RPTDYSCA
*: : .:. . : :* . :.:
Mvan_1925|M.vanbaalenii_PYR-1 WNTWEEVAREHG-HVADRAKWRLVGPMHLAETREQAERDVEYGIA--QFS
Mflv_4429|M.gilvum_PYR-GCK WNTWDEVAREHG-HQADRSKWRLVGPMHLAETREQAERDVEYGIA--EFS
MUL_2949|M.ulcerans_Agy99 WGIVEERAAAFG-THADRKNWTLVGPFHIAETDAQARADVKFGIE--PWF
MSMEG_6107|M.smegmatis_MC2_155 WNVVRDEAAAAGRPEPDRENWRVLGIVHLADTREQAIEDCTYGLQ--DFA
TH_0993|M.thermoresistible__bu WDVVVQQAAKAGRPEPDRANWRVLGIVHLADTREQALQDCTYGLQ--DFA
Rv3618|M.tuberculosis_H37Rv WGVVREQAAKAGRGEPDRADWRVLSIMHLSDSRDQAIDDCTYGLP--DFS
MMAR_5115|M.marinum_M WQVVCEQAAKVGRAEPNRRDWRVLSIMHLSDTRDQAIQDCIYGLP--DFS
MAV_0538|M.avium_104 WDVVREQAAKAGRDEPDRGDWRVLSIMHIADSREQAIDDCTYGLQ--DFA
MAB_0527c|M.abscessus_ATCC_199 WEVVREQAEIHGHPEPDRSSWRVLGIMHLAETRDQAIADCTYGLP--DYA
Mb1971|M.bovis_AF2122/97 WDAVEEGALRSG-RTPDRRDWRLVREVLVAETDEQAFRYAVDGTMGRAMR
MLBr_00131|M.leprae_Br4923 LEVVRTAASDAG-RDPMSITPAAVRGIITGRTRDDVDEALDSVLVR-MIA
* * . : . . : :.
Mvan_1925|M.vanbaalenii_PYR-1 QYFS--HILPAG-PVQGDT----PAEIIANNHASGFAVIGTPQDAIAKIE
Mflv_4429|M.gilvum_PYR-GCK RYFT--HILPSG-PVQGDT----PEEIIANNRQSGFAVIGTPDDAIAKIS
MUL_2949|M.ulcerans_Agy99 RYFQKVAAFPQM-TMPGEQ----LDEMIDIINENGAGVIGTPERARAQVQ
MSMEG_6107|M.smegmatis_MC2_155 NYFGAAGFVPLSNQAEGGG---TPYEFVENYASKGNCCIGTPDDAIVYIQ
TH_0993|M.thermoresistible__bu NYFGAAGFVPLANEVAGGQ---SPREFVEAYAEKGNCCIGTPGDAIVYLS
Rv3618|M.tuberculosis_H37Rv RYFGAAGFVPLANTVEGTQ---SSREFVEQYAAKGNCCIGTPDDAIAHIE
MMAR_5115|M.marinum_M KYFGAAGFVPLSNATDGAE---GTREFVEDYAAKGNCCIGTPEDAIAYIE
MAV_0538|M.avium_104 NYFGAAGFVPLANSVEGTQ---TPHEFVAEYAAKGNCCIGTPEDAIAHIE
MAB_0527c|M.abscessus_ATCC_199 HYFGAVGVLPLANSADGADGAIDPHEFVKAYADEGNCCIGTPEDAIEYIQ
Mb1971|M.bovis_AF2122/97 EYVLPTFRMFGMTKFYKHNPSVPDDEVTPEYLAENTFVVGSVQTVVDKLE
MLBr_00131|M.leprae_Br4923 LGVPGEAWARHGVEHPMGADFAGVQDIIPQTIDEETVVSYAAKVPAALMK
. :. . : :.
Mvan_1925|M.vanbaalenii_PYR-1 ELVEASNGGFGTFLLFDHDWAP-PAAKLRSYELFAEYVIPHFTGQLSAPI
Mflv_4429|M.gilvum_PYR-GCK ELVEASDGGFGAFLLFDHDWAP-PAAKLRSYELFAQYVIPHFTGQLSAPI
MUL_2949|M.ulcerans_Agy99 RLWDQS-GGFGCMLQMGHEWAN-PAATRRSAELFAAEVMPHFQGQAQPTL
MSMEG_6107|M.smegmatis_MC2_155 DLLDRS-GGFGTFLLLGHDWAP-PAATFHSYELFAREVIPHFKGQLTAAR
TH_0993|M.thermoresistible__bu DLLERS-GGFGTFLMLGHDWAS-PQATYHSYELFAREVIPHFKGQLTAPR
Rv3618|M.tuberculosis_H37Rv DLLHRS-GGFGTLLLLGHDWAP-PPATFHSYELFARAVIPYFKGQLAAPR
MMAR_5115|M.marinum_M DLLNRS-GGFGTLLLLGHDWAS-PQATFHSYDLFARKVIPYFKGQLEAPR
MAV_0538|M.avium_104 DLLDRS-GGFGTLLMLGHDWAS-PEATYHCYDLMARKVIPHFKRQLDASR
MAB_0527c|M.abscessus_ATCC_199 GLLDTS-GGFGTFLMLGHDWAA-PEATFKSYELFARKVIPHFTGQLTAAQ
Mb1971|M.bovis_AF2122/97 ATYDQV-GGFGHLLILGFDYSDNPGPWKESLRLLAHEVMPRLNARLATKP
MLBr_00131|M.leprae_Br4923 EVLFSG--TPEEVIDQVAEWRD--HGLKYLVVINGSLVNSSLRKTVSALL
.: :: : . * . : .
Mvan_1925|M.vanbaalenii_PYR-1 ASRDWVTESGRTFVDQAAHAIGKAIEDHAAEQQAKSPTPS-
Mflv_4429|M.gilvum_PYR-GCK ASRDWVTESGRVFVDQATHAIGRAIESHAAEQQAKQSRTSD
MUL_2949|M.ulcerans_Agy99 DAAVRAGEVREGLAQTQLQAIDHMTKKYQQELDGK------
MSMEG_6107|M.smegmatis_MC2_155 ASHDWAKGMRDQLLGRAGQAIVNAITEHTQAHPAENEN---
TH_0993|M.thermoresistible__bu ASHDWAKQMRGQLLGRAGEAIVKAIGEHTSEQEQR------
Rv3618|M.tuberculosis_H37Rv ASHEWARGKRDQLIGRAGEAVVKAITEHVAEQGEAGS----
MMAR_5115|M.marinum_M ASHEWARDKREDLIGRAGQAVVAAITEHVTERGEGQT----
MAV_0538|M.avium_104 ASHDWAKGMRDQLLGRAGEAVVKAISEHVDEHKDAVH----
MAB_0527c|M.abscessus_ATCC_199 ASHDWAQAKRGELLGRAGDAVAKAIGEHVAQKASH------
Mb1971|M.bovis_AF2122/97 ATAVV------------------------------------
MLBr_00131|M.leprae_Br4923 PHARVLRGLKKL-----------------------------