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M. thermoresistible (build 8) TH_0718 (pdhA)

annotation: PROBABLE PYRUVATE DEHYDROGENASE E1 COMPONENT (ALPHA SUBUNIT) PDHA (PYRUVATE DECARBOXYLASE) (PYRUVATE DEHYDROGENASE) (PYRUVIC DEHYDROGENASE)
coordinates: 1539491 - 1540588
length: 366

aa seq not available

Operon Prediction Model: Genebank

Paralogs

species id gene e-value identity (len) annotation
M. thermoresistible (build 8) TH_0718 pdhA - 100% (366) PROBABLE PYRUVATE DEHYDROGENASE E1 COMPONENT (ALPHA SUBUNIT) PDHA (PYRUVATE DECARBOXYLASE) (PYRUVATE DEHYDROGENASE) (PYRUVIC DEHYDROGENASE)
M. thermoresistible (build 8) TH_4167 - 1e-39 36.54% (312) PUTATIVE acetoin:2,6-dichlorophenolindophenol oxidoreductase

Closest Orthologs (e-value cutoff: 1e-4)

species id gene e-value identity (len) annotation
M. bovis AF2122 / 97 Mb2525c pdhA 1e-147 72.09% (344) pyruvate dehydrogenase E1 component alpha subunit PdhA
M. gilvum PYR-GCK - - - - -
M. tuberculosis H37Rv Rv2497c pdhA 1e-147 72.09% (344) pyruvate dehydrogenase E1 component alpha subunit PdhA
M. leprae Br4923 - - - - -
M. abscessus ATCC 19977 MAB_0897c - 5e-78 43.73% (359) pyruvate dehydrogenase E1 component, alpha subunit
M. marinum M MMAR_3844 pdhA 1e-146 72.67% (344) pyruvate dehydrogenase E1 component (alpha subunit) PdhA
M. avium 104 MAV_1675 - 1e-149 71.80% (344) pyruvate dehydrogenase E1 component, alpha subunit
M. smegmatis MC2 155 MSMEG_4712 - 1e-157 77.52% (347) pyruvate dehydrogenase E1 component, alpha subunit
M. ulcerans Agy99 MUL_3775 pdhA 1e-144 71.51% (344) pyruvate dehydrogenase E1 component (alpha subunit) PdhA
M. vanbaalenii PYR-1 Mvan_4086 - 1e-159 76.06% (355) pyruvate dehydrogenase (acetyl-transferring)

CLUSTAL 2.0.9 multiple sequence alignment


MSMEG_4712|M.smegmatis_MC2_155      --MAMQYSSAPGYDTGFDPEPVQLVAADGSPSPDRPPSRYSRDLPPETLS
Mvan_4086|M.vanbaalenii_PYR-1       ---MAGLSALSELD-----EPIQLVAPDGAPTPE---SRYRRDLPPETLA
TH_0718|M.thermoresistible__bu      ----MGHPGVLDCE-----ASVQLVAPDGTATDE---HRYSRDLPPGVLR
Mb2525c|M.bovis_AF2122/97           --MGEGSRRPSGMLMSVDLEPVQLVGPDGTPTAE---RRYHRDLPEETLR
Rv2497c|M.tuberculosis_H37Rv        --MGEGSRRPSGMLMSVDLEPVQLVGPDGTPTAE---RRYHRDLPEETLR
MMAR_3844|M.marinum_M               --MADRPRIP----MTVGLEPVQLVNADGEPTDE---HRYSRDLPEETLC
MUL_3775|M.ulcerans_Agy99           --------------MTVGLEPVQLVNADGEPTDE---HRYSRDLPEETLC
MAV_1675|M.avium_104                --MAQTSQPP----MTVDLQPVQLVAADGTPTSE---HRYSRELPAETLS
MAB_0897c|M.abscessus_ATCC_199      MTVAEPADRPAYQAFLPADSAVQFLDPEGRPVDGG--ARYPR-PDADRLL
                                                        .:*:: .:* .       ** *      * 

MSMEG_4712|M.smegmatis_MC2_155      WLYESMVVTRNLDVEFVNLQRQGELALFASCRGQEAAQIGAAACLRKTDW
Mvan_4086|M.vanbaalenii_PYR-1       WLYESMVVTRELDTEFVNLQRQGELALFASCRGQEAAQIGAAACLRKTDW
TH_0718|M.thermoresistible__bu      RLYELMVVTRDLDAEFVNLQRQGELALYPSCRGQEAAQVGAAACLRDIDW
Mb2525c|M.bovis_AF2122/97           WLYEMMVVTRELDTEFVNLQRQGELALYTPCRGQEAAQVGAAACLRKTDW
Rv2497c|M.tuberculosis_H37Rv        WLYEMMVVTRELDTEFVNLQRQGELALYTPCRGQEAAQVGAAACLRKTDW
MMAR_3844|M.marinum_M               WLYEMMVVTRELDAEFINLKRQGELALFASCRGQEAAQVGATACLRKTDW
MUL_3775|M.ulcerans_Agy99           WLYEMMVVTRELDAEFINLKRQGELALFASCRGQEAAQVGATACLRKTDW
MAV_1675|M.avium_104                WLYEMMVLTRELDGEFVNLKRQGQLALFASCRGQEAAQVGATACLRKTDW
MAB_0897c|M.abscessus_ATCC_199      AMYRNMVLGRRFDEQATALTKQGRLAVYPSSRGQEACQIAAAMCLHSDDW
                                     :*. **: * :* :   * :**.**::...*****.*:.*: **:. **

MSMEG_4712|M.smegmatis_MC2_155      LFPQYREIGAFLLRGITPAQMGAVWRGKWHGGLSFTGKCVAPIAIPIGTH
Mvan_4086|M.vanbaalenii_PYR-1       LFPQYRELGAFLVRAIAPAQLGALWRGRWHGGLGFTDRCVAPVSIPIGTH
TH_0718|M.thermoresistible__bu      LFPQYRELGAFLTRGITPQQLAEVWRGSWHGGSGFTAKRCAPIAIPIATH
Mb2525c|M.bovis_AF2122/97           LFPQYRELGVYLVRGIPPGHVGVAWRGTWHGGLQFTTKCCAPMSVPIGTQ
Rv2497c|M.tuberculosis_H37Rv        LFPQYRELGVYLVRGIPPGHVGVAWRGTWHGGLQFTTKCCAPMSVPIGTQ
MMAR_3844|M.marinum_M               LFPQYRELGAYLVRGIPPGHVGAAWRGTWHGGLEFTKKCCAPISVPIGTQ
MUL_3775|M.ulcerans_Agy99           LFPQYRELGAYLVRGIPPGHVGAAWRGTWHGGLEFTKKCCVPISVPIGTQ
MAV_1675|M.avium_104                LFPQYRELGAFLVRGIPPGNVGAVWRGTWHGGLGFTDKCCAPLSIPIGTQ
MAB_0897c|M.abscessus_ATCC_199      LFPTYRDSMALAARGIDTVDILRFLAGDWHCCFDPAQHRTAPQATPLATQ
                                    *** **:  .   *.* . .:     * **     : :  .* : *:.*:

MSMEG_4712|M.smegmatis_MC2_155      GLHAVGAAMAAQRLGEDSVTVAFLGDGATSEGDAHEAFNLATVFRAPCVF
Mvan_4086|M.vanbaalenii_PYR-1       GLHAVGAAMAAQRLGEDSVTVAFLGDGATSEGDAHEALNLAAVFGAPCVF
TH_0718|M.thermoresistible__bu      TLHAVGAAMAAQRLGEDSVTVAFLGDGATSEGDAHEALNLAAVYRAPCVF
Mb2525c|M.bovis_AF2122/97           TLHAVGAAMAAQRLDEDSVTVAFLGDGATSEGDVHEALNFAAVFTTPCVF
Rv2497c|M.tuberculosis_H37Rv        TLHAVGAAMAAQRLDEDSVTVAFLGDGATSEGDVHEALNFAAVFTTPCVF
MMAR_3844|M.marinum_M               ALHAVGAAMAAQRLGEDSVTVAFLGDGATSEGDVHEALNFAAVFDAGCVF
MUL_3775|M.ulcerans_Agy99           ALHAVGAAQAAQRLGEDSVTVAFLGDGATSEGDVHEALNFAAVFDAGCVF
MAV_1675|M.avium_104                TLHAVGAAMAAQRLGEDSVTIAFLGDGATSVGDVHEALNFAAVFRTPCVF
MAB_0897c|M.abscessus_ATCC_199      LLHAAGLAHALARKGSDTAVLALCGDGATSEGDFHEALNFAAVFRAPVIF
                                     ***.* * *  * ..*:..:*: ****** ** ***:*:*:*: :  :*

MSMEG_4712|M.smegmatis_MC2_155      FIQNNQWAISVPVSRQQAGPTIAHRAIGYGMPGIRVDGNDVLACYAVMSE
Mvan_4086|M.vanbaalenii_PYR-1       FVQNNQWAISVPVERQHAGPTLAHRAIGYGMPGVRVDGNDVLACFAVMEQ
TH_0718|M.thermoresistible__bu      FVQNNGWAISVPVSRQHAAPTLAHRGVGYGMPGIRVDGNDVLACYAVMAE
Mb2525c|M.bovis_AF2122/97           YVQNNQWAISMPVSRQTAAPSIAHKAIGYGMPGIRVDGNDVLACYAVMAE
Rv2497c|M.tuberculosis_H37Rv        YVQNNQWAISMPVSRQTAAPSIAHKAIGYGMPGIRVDGNDVLACYAVMAE
MMAR_3844|M.marinum_M               YVQNNQWAISVPVSKQTAAPSIAHKAIGYGMPGIRVDGNDVLACYAVTAE
MUL_3775|M.ulcerans_Agy99           YVQNNQWAISVPVSKQTAAPSIAHKAIGYGMPGIRVDGNDVLACYAVTAV
MAV_1675|M.avium_104                FVQNNQWAISLPVAKQTASPSLAHKAIGYGMPGIRVDGNDVLACYAVTAE
MAB_0897c|M.abscessus_ATCC_199      LVQNNGFAISVPLARQSVAPSLAHKGIGYGMGSEQVDGNDPVAMLAVLDA
                                     :*** :***:*: :* ..*::**:.:**** . :***** :*  **   

MSMEG_4712|M.smegmatis_MC2_155      AAERARRGEGPTLIEAVTYRMGPHTTSDDPTRYRPAEEVEAWAARDPIAR
Mvan_4086|M.vanbaalenii_PYR-1       AAARAREGGGPTFIEAVTYRMGPHTTSDDPTRYRSDEEVEHWRARDPIAR
TH_0718|M.thermoresistible__bu      AVERARTGGGPTLIEAVTYRMGPHTTSDDPTRYRSEAELQHWAALDPLSR
Mb2525c|M.bovis_AF2122/97           AAARARAGDGPTLIEAVTYRLGPHTTADDPTRYRSQEEVDRWATLDPIPR
Rv2497c|M.tuberculosis_H37Rv        AAARARAGDGPTLIEAVTYRLGPHTTADDPTRYRSQEEVDRWATLDPIPR
MMAR_3844|M.marinum_M               AAARARRGDGPTLIEAVTYRVGAHTTADDPGRYRSQEEVDHWLALDPISR
MUL_3775|M.ulcerans_Agy99           AAARARRGDGPTLIEAVTYRVGAHTTADDPGRYRSQEEVDHWLALDPISR
MAV_1675|M.avium_104                AAARARAGGGPTLIEAITYRLGPHTTSDDPTRYRTQDEVDHWAALDPIPR
MAB_0897c|M.abscessus_ATCC_199      AREYVLAGNGPVIVEAHTYRMSGHTNADDPLRYRTDDELDEWLARDPIQR
                                    *   .  * **.::** ***:. **.:*** ***.  *:: * : **: *

MSMEG_4712|M.smegmatis_MC2_155      YRTYLQNIGVWTERLEERVAARSSRLCAELRDAIVGAPDVDPAEMFDTVY
Mvan_4086|M.vanbaalenii_PYR-1       YRTYLEHTGVWTQRLEERVAHRSQRLRAELRDAVITEPDIDIGEVFDTVY
TH_0718|M.thermoresistible__bu      YRDYLTAVGVWTDHLEEHVAAESSRLRTELRDAVVGAPDIDIAEVFDTVF
Mb2525c|M.bovis_AF2122/97           YRTYLQDQGLWSQRLEEQVTARAKHVRSELRDAVFDAPDFDVDEVFTTVY
Rv2497c|M.tuberculosis_H37Rv        YRTYLQDQGLWSQRLEEQVTARAKHVRSELRDAVFDAPDFDVDEVFTTVY
MMAR_3844|M.marinum_M               YRSYLQGQGLWSQRLEERVAARSGRLRAELREAVFGASDFDVDDVFTTVF
MUL_3775|M.ulcerans_Agy99           YRSYLQGQGLWSQRLEVRVAARSGRLRAELREAVFGASDFDVDDVFTTVF
MAV_1675|M.avium_104                YRSYLQGQGLWSERLEERVIGRATRMRAELRDAVFDAPDLDVDEVFTAVY
MAB_0897c|M.abscessus_ATCC_199      LEIHLRAEGLLDDTYVAAVASDAEDLAATTRAGMNRDRPVDVDDLFRYVY
                                     . :*   *:  :     *   :  : :  * .:     .*  ::*  *:

MSMEG_4712|M.smegmatis_MC2_155      ADITPELARQRDQLLSELAKEA-----
Mvan_4086|M.vanbaalenii_PYR-1       HDITPDLARQRDELLAELAKEA-----
TH_0718|M.thermoresistible__bu      SDITPDLARQRDELLAELGCRRRDGRG
Mb2525c|M.bovis_AF2122/97           AEITPGLQAQREQLRAELARTD-----
Rv2497c|M.tuberculosis_H37Rv        AEITPGLQAQREQLRAELARTD-----
MMAR_3844|M.marinum_M               AEITPGLQTQRQQLRAELDRID-----
MUL_3775|M.ulcerans_Agy99           AEITPGLQTQRQQLRAELDRID-----
MAV_1675|M.avium_104                AEITPELQAQRRALRTELEKSD-----
MAB_0897c|M.abscessus_ATCC_199      AQPTSQLREQHAQARADFTAQLSEDRP
                                     : *. *  *:    :::

species	id	gene	e-value	identity (len)	annotation
M. thermoresistible (build 8)	TH_0718	pdhA	-	100% (366)	PROBABLE PYRUVATE DEHYDROGENASE E1 COMPONENT (ALPHA SUBUNIT) PDHA (PYRUVATE DECARBOXYLASE) (PYRUVATE DEHYDROGENASE) (PYRUVIC DEHYDROGENASE)
M. thermoresistible (build 8)	TH_4167	-	1e-39	36.54% (312)	PUTATIVE acetoin:2,6-dichlorophenolindophenol oxidoreductase